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https://www.readbyqxmd.com/read/28492025/validation-studies-of-outcome-measures-in-pemphigus
#1
REVIEW
Sarah Hanna, Minhee Kim, Dedee F Murrell
Pemphigus is a group of rare and potentially fatal autoimmune blistering diseases that are associated with auto-antibodies that target intercellular adhesion molecules. Incidence of pemphigus varies among populations, with the lowest incidence in Switzerland and Finland at 0.6-0.76 per million per year and the highest in Jewish communities at 16.1-32 per million per year. Pemphigus is associated with devastating morbidity and despite advancements in our understanding of the disease and a widening array of therapeutic options, no cure exists...
December 2016: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28486366/changes-in-myomectomy-practice-after-the-u-s-food-and-drug-administration-safety-communication-on-power-morcellation
#2
Natalie C Stentz, Laura G Cooney, Mary Sammel, Divya K Shah
OBJECTIVE: To examine the association between the 2014 U.S. Food and Drug Administration (FDA) safety communication on power morcellation and surgical approach and morbidity after myomectomy. METHODS: In this retrospective cohort study, data were abstracted from the American College of Surgeons National Surgical Quality Improvement Program database on 3,160 myomectomies between April 2012 and December 2013 (pre-FDA) and 4,378 between April 2014 and December 2015 (post-FDA)...
May 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28471711/rising-prices-of-targeted-oral-anticancer-medications-and-associated-financial-burden-on-medicare-beneficiaries
#3
Ya-Chen Tina Shih, Ying Xu, Lei Liu, Fabrice Smieliauskas
Purpose The high cost of oncology drugs threatens the affordability of cancer care. Previous research identified drivers of price growth of targeted oral anticancer medications (TOAMs) in private insurance plans and projected the impact of closing the coverage gap in Medicare Part D in 2020. This study examined trends in TOAM prices and patient out-of-pocket (OOP) payments in Medicare Part D and estimated the actual effects on patient OOP payments of partial filling of the coverage gap by 2012. Methods Using SEER linked to Medicare Part D, 2007 to 2012, we identified patients who take TOAMs via National Drug Codes in Part D claims...
May 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28463757/impact-of-detection-bias-on-the-risk-of-gastrointestinal-cancer-and-its-subsites-in-type-2-diabetes-mellitus
#4
R G P J de Jong, A M Burden, S de Kort, M P P van Herk-Sukel, P A J Vissers, P K C Janssen, H R Haak, A A M Masclee, F de Vries, M L G Janssen-Heijnen
BACKGROUND: Type 2 diabetes mellitus (T2DM) may be a risk factor for gastrointestinal (GI) cancers, but variations in study designs of observational studies may have yielded biased results due to detection bias. Furthermore, differences in risk for GI cancer subsites have not been extensively evaluated. We aimed to determine the risk of GI cancer and its subsites in patients with T2DM and how it is affected by detection bias. METHODS: A matched cohort study was performed using the NCR-PHARMO database...
April 29, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28456089/the-30-year-experience-a-meta-analysis-of-randomised-and-high-quality-non-randomised-studies-of-hyperthermic-intraperitoneal-chemotherapy%C3%A2-in-the-treatment-of-gastric-cancer
#5
REVIEW
Jacopo Desiderio, Joseph Chao, Laleh Melstrom, Susanne Warner, Federico Tozzi, Yuman Fong, Amilcare Parisi, Yanghee Woo
IMPORTANCE: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been used within various multimodality strategies for the prevention and treatment of gastric cancer peritoneal carcinomatosis. OBJECTIVE: To systematically evaluate the role of HIPEC in gastric cancer and clarify its effectiveness at different stages of peritoneal disease progression. DATA SOURCES: Medline and Embase databases between January 1, 1985 and June 1, 2016. STUDY SELECTION: Randomised control trials and high-quality non-randomised control trials selected on a validated tool (methodological index for non-randomised studies) comparing HIPEC and standard oncological management for the treatment of advanced stage gastric cancer with and without peritoneal carcinomatosis were considered...
April 26, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28448783/effectiveness-of-a-clinical-pharmacist-medication-therapy-management-program-in-discontinuation-of-drugs-to-avoid-in-the-elderly
#6
Nicole Caffiero, Thomas Delate, Mercy D Ehizuelen, Kris Vogel
BACKGROUND: Despite evidence of fall risk associated with some drugs to avoid in the elderly (DAEs), many aged patients continue to receive them. OBJECTIVE: To assess the effectiveness of a clinical pharmacist medication therapy management program (MTM) on discontinuation of prescribed DAEs. METHODS: This was a retrospective cohort study conducted at an integrated health care delivery system. Kaiser Permanente Colorado beneficiaries aged ≥65 years who were MTM-eligible and targeted for a DAE dispensing between 01/01/2015 and 09/30/2015 were included in the observation group...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28416498/deprescribing-anticholinergic-and-sedative-medicines-protocol-for-a-feasibility-trial-defeat-polypharmacy-in-residential-aged-care-facilities
#7
Nagham Ailabouni, Dee Mangin, Prasad S Nishtala
INTRODUCTION: Targeted deprescribing of anticholinergic and sedative medicines can lead to positive health outcomes in older people; as they have been associated with cognitive and physical functioning decline. This study will examine whether the proposed intervention is feasible at reducing the prescription of anticholinergic and sedative medicines in older people. METHODS AND ANALYSIS: The Standard Protocol Items: Recommendations for Interventional trials (SPIRIT checklist) was used to develop and report the protocol...
April 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28399914/healthcare-burden-of-pulmonary-hypertension-owing-to-lung-disease-and-or-hypoxia
#8
Gustavo A Heresi, David M Platt, Wenyi Wang, Christine H Divers, Vijay N Joish, Simon A Teal, Justin S Yu
BACKGROUND: Group 3 pulmonary hypertension (PH) encompasses PH owing to lung diseases and/or hypoxia. Treatment patterns, healthcare resource use, and economic burden to US payers of Group 3 PH patients were assessed. METHODS: This retrospective observational study extracted data from July 1, 2010 to June 30, 2013 from two Truven Health Analytics MarketScan databases. Adult Group 3 PH patients were identified based on claims for PH (ICD-9-CM 416.0/416.8), a related lung disease, and an echocardiogram or right heart catheterization (RHC)...
April 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28397756/anti-trypanosomatid-elemanolide-sesquiterpene-lactones-from-vernonia-lasiopus-o-hoffm
#9
Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt
Sleeping sickness or human African trypanosomiasis (HAT) is a neglected tropical disease (NTD) threatening millions of peoples' lives with thousands infected. The disease is endemic in poorly developed regions of sub-Saharan Africa and is caused by the kinetoplastid "protozoan" parasite Trypanosoma brucei. The parasites are transmitted to humans through bites of infected tsetse flies of the genus Glossina. The few available drugs for treatment of this disease are highly toxic, difficult to administer, costly and unavailable to poor rural communities bearing the major burden of this infection...
April 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28388648/trends-in-medicines-procurement-by-the-brazilian-federal-government-from-2006-to-2013
#10
Tatiana Chama Borges Luz, Claudia Garcia Serpa Osorio-de-Castro, Rachel Magarinos-Torres, Bjorn Wettermark
The costs of medicines pose a growing burden on healthcare systems worldwide. A comprehensive understanding of current procurement processes provides strong support for the development of effective policies. This study examined Brazilian Federal Government pharmaceutical procurement data provided by the Integrated System for the Administration of General Services (SIASG) database, from 2006 to 2013. Medicine purchases were aggregated by volume and expenditure for each year. Data on expenditure were adjusted for inflation using the Extended National Consumer Price Index (IPCA) for December 31, 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28384095/age-specific-indicators-of-a-healthy-lifestyle-and-postmenopausal-breast-cancer
#11
Kathleen M McClain, Lauren E McCullough, Patrick T Bradshaw, Sumitra Shantakumar, Mary Beth Terry, Alfred I Neugut, Marilie D Gammon
INTRODUCTION: Modifiable lifestyle factors have been consistently associated with breast cancer, and risk may vary by menopausal status. However, whether these associations vary according to age among postmenopausal women remains unresolved. METHODS: Using postmenopausal women from a population-based case-control study (990 cases and 1006 frequency-matched controls), we conducted multivariable-adjusted unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for lifestyle factors (lifetime alcohol intake, body mass index [BMI] in the year before diagnosis, lifetime recreational physical activity [RPA], and nonsteroidal anti-inflammatory drug use) in association with breast cancer stratified by age (<65 vs...
April 6, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28382808/weaning-of-neurological-early-rehabilitation-patients-from-mechanical-ventilation-a-retrospective-observational-study
#12
Jens D Rollnik, Joachim K Krauss, Christoph Gutenbrunner, Claus Wallesch, Thomas Münte, Martin Stangel
BACKGROUND: There is little known about the factors influencing the weaning process of long-term mechanically ventilated patients in the neurological early rehabilitation. AIM: To identify salient clinical and neurophysiological variables with impact upon weaning from mechanical ventilation during neurological and neurosurgical early rehabilitation. DESIGN: Observational, retrospective data analysis. POPULATION: A sample of 65 mechanically ventilated neurological and neurosurgical early rehabilitation patients of the BDH-Clinic Hessisch Oldendorf in Northern Germany...
April 4, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28376239/clinical-characteristics-disease-activity-and-patient-reported-outcomes-in-psoriatic-arthritis-patients-with-dactylitis-or-enthesitis-results-from-the-corrona-psoriatic-arthritis-spondyloarthritis-registry
#13
Philip J Mease, Chitra Karki, Jacqueline B Palmer, Carol J Etzel, Arthur Kavanaugh, Christopher T Ritchlin, Wendi Malley, Vivian Herrera, Melody Tran, Jeffrey D Greenberg
OBJECTIVE: Characterize psoriatic arthritis (PsA) patients with dactylitis or enthesitis and evaluate the associations of these manifestations with disease activity and patient-reported outcomes. METHODS: Using the Corrona PsA/Spondyloarthritis Registry, patient characteristics, disease activity, and patient-reported outcomes at registry enrollment were assessed for PsA patients aged ≥ 18 years with or without dactylitis or enthesitis. Regression models were used to evaluate associations of dactylitis and enthesitis with outcomes including Minimal Disease Activity, Health Assessment Questionnaire scores, patient-reported pain and fatigue, and work productivity (Work Productivity and Activity Impairment questionnaire)...
April 4, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28370922/identification-and-content-validation-of-wound-therapy-clinical-endpoints-relevant-to-clinical-practice-and-patient-values-for-fda-approval-part-1-survey-of-the-wound-care-community
#14
Vickie R Driver, Lisa J Gould, Peggy Dotson, Gary W Gibbons, William W Li, William J Ennis, Robert S Kirsner, William H Eaglstein, Laura L Bolton, Marissa J Carter
Wounds that exhibit delayed healing add extraordinary clinical, economic, and personal burdens to patients, as well as to increasing financial costs to health systems. New interventions designed to ease such burdens for patients with cancer, renal, or ophthalmologic conditions are often cleared for approval by the U.S. Food and Drug Administration (FDA) using multiple endpoints but the requirement of complete healing as a primary endpoint for wound products impedes FDA clearance of interventions that can provide other clinical or patient-centered benefits for persons with wounds...
April 3, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28355223/pre-control-relationship-of-onchocercal-skin-disease-with-onchocercal-infection-in-guinea-savanna-northern-nigeria
#15
Michele E Murdoch, Ian E Murdoch, Jennifer Evans, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R Jones, Adenike Abiose
BACKGROUND: Onchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness. METHODS: A clinical classification system of the cutaneous changes in onchocerciasis was used for the first time in this study within the context of an early ivermectin drug trial in the savanna region of Kaduna State, northern Nigeria. Skin examinations were performed in 6,790 individuals aged 5+ years in endemic communities and 1,343 individuals in nonendemic communities...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28346565/anticholinergic-burden-and-functional-status-in-older-people-with-cognitive-impairment-results-from-the-regal-project
#16
V Boccardi, M Baroni, L Paolacci, S Ercolani, A Longo, M Giordano, C Ruggiero, P Mecocci
OBJECTIVE: The use of drugs with intrinsic anticholinergic properties is widespread among old age persons. A growing body of evidences suggest that a high anticholinergic burden is associated with physical and cognitive impairment. However, the association between anticholinergic drug use and functional status is still poorly investigated, particularly among subjects with initial cognitive impairment. DESIGN: Cross-sectional study examining the association between drug-related anticholinergic burden and functional status in cognitively healthy (CH) (n=691), mild cognitive impairment (MCI) (n=541) or mild Alzheimer's diseases (AD) (n=1127) subjects...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28320328/expenditures-of-medicine-use-in-hypertensive-diabetic-elderly-and-physical-activity-and-engagement-in-walking-cross-secctional-analysis-of-sabe-survey
#17
Denise Rodrigues Bueno, Maria de Fátima Nunes Marucci, Luis Alberto Gobbo, Manuela de Almeida-Roediger, Yeda Aparecida de Oliveira Duarte, Maria Lucia Lebrão
BACKGROUND: The literature shows the inverse association between physical activity level (PAL) and chronic diseases that have a significant burden over health care costs. However, in upper-middle income countries and in elderly population this information are scarce. OBJECTIVE: To describe the annual drug expenditures for the hypertensive and diabetic elderly population in Brazil and to analyze the association with PAL and engagement in walking. METHODS: This cross sectional study is part of SABE Survey and comprised 806 hypertensive and/or diabetic elderly (≥60 years old)...
March 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28318137/plaque-erosion-delays-vascular-healing-after-drug-eluting-stent-implantation-in-patients-with-acute-coronary-syndrome-an-in-vivo-optical-coherence-tomography-study
#18
COMPARATIVE STUDY
Sining Hu, Chao Wang, Chunyang Zhe, Yinchun Zhu, Taishi Yonetsu, Haibo Jia, Jingbo Hou, Shaosong Zhang, Ik-Kyung Jang, Bo Yu
OBJECTIVES: To compare vascular healing after drug-eluting stent (DES) implantation between plaque rupture (PR) and plaque erosion (PE). BACKGROUND: Vascular response after stent implantation in patients with PR has been extensively studied. Little is known about vascular healing after stent implantation in PE. METHODS: Sixty-five ACS patients who received optical coherence tomography (OCT) imaging of the culprit lesions both before and after stent implantation at baseline as well as at 6 months were included in this study...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28289016/gambling-problems-among-patients-in-primary-care-a-cross-sectional-study-of-general-practices
#19
Sean Cowlishaw, Lone Gale, Alison Gregory, Jim McCambridge, David Kessler
BACKGROUND: Primary care is an important context for addressing health-related behaviours, and may provide a setting for identification of gambling problems. AIM: To indicate the extent of gambling problems among patients attending general practices, and explore settings or patient groups that experience heightened vulnerability. DESIGN AND SETTING: Cross-sectional study of patients attending 11 general practices in Bristol, South West England...
March 13, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28283492/prevalence-of-latent-tb-infection-and-tb-disease-among-adolescents-in-high-tb-burden-countries-in-africa-a-systematic-review-protocol
#20
Erick Wekesa Bunyasi, Bey-Marrie Schmidt, Leila Hussein Abdullahi, Humphrey Mulenga, Michele Tameris, Angelique Luabeya, Justin Shenje, Thomas Scriba, Hennie Geldenhuys, Robin Wood, Mark Hatherill
INTRODUCTION: Almost a third of the world population has latent tuberculosis (TB) infection (LTBI), ∼10 million of whom develop TB disease annually, despite existence of effective, but lengthy, preventive and curative drug regimens. Although adolescents appear to have a very high force of LTBI, their reported incidence of TB disease is less than that of their corresponding general population. The few available studies on adolescent TB infection and disease prevalence are not sufficient to address the apparent discordance between rates of infection and disease in high TB burden countries in Africa...
March 10, 2017: BMJ Open
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