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https://www.readbyqxmd.com/read/29754330/gender-differences-in-axial-spondyloarthritis-women-are-not-so-lucky
#1
REVIEW
T Rusman, R F van Vollenhoven, I E van der Horst-Bruinsma
PURPOSE OF REVIEW: Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gender distribution. The purpose of this review is to aggregate the existing data on gender differences in axSpA in order to increase the awareness that female axSpA patients are still under-recognized...
May 12, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29740700/the-best-of-two-worlds-pulmonary-vein-isolation-using-a-novel-radiofrequency-ablation-catheter-incorporating-contact-force-sensing-technology-and-56-hole-porous-tip-irrigation
#2
Tilman Maurer, Laura Rottner, Hisaki Makimoto, Bruno Reissmann, Christian-H Heeger, Christine Lemes, Thomas Fink, Johannes Riedl, Francesco Santoro, Peter Wohlmuth, Marius Volkmer, Shibu Mathew, Andreas Metzner, Feifan Ouyang, Karl-Heinz Kuck, Christian Sohns
AIMS: This study aimed to evaluate feasibility and safety as well as 1-year clinical outcome of pulmonary vein isolation (PVI) using a unique radiofrequency ablation catheter ("Thermocool SmartTouch SurroundFlow"; STSF) incorporating both, contact force (CF) sensing technology and enhanced tip irrigation with 56 holes, in one device. METHODS: A total of 110 patients suffering from drug-refractory atrial fibrillation underwent wide area circumferential PVI using either the STSF ablation catheter (75 consecutive patients, study group) or a CF catheter with conventional tip irrigation ("Thermocool SmartTouch", 35 consecutive patients, control group)...
May 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29736815/anticholinergic-drug-burden-tools-scales-and-adverse-outcomes-in-different-clinical-settings-a-systematic-review-of-reviews
#3
REVIEW
Tomas J Welsh, Veronika van der Wardt, Grace Ojo, Adam L Gordon, John R F Gladman
BACKGROUND: Cumulative anticholinergic exposure (anticholinergic burden) has been linked to a number of adverse outcomes. To conduct research in this area, an agreed approach to describing anticholinergic burden is needed. OBJECTIVE: This review set out to identify anticholinergic burden scales, to describe their rationale, the settings in which they have been used and the outcomes associated with them. METHODS: A search was performed using the Healthcare Databases Advanced Search of MEDLINE, EMBASE, Cochrane, CINAHL and PsycINFO from inception to October 2016 to identify systematic reviews describing anticholinergic burden scales or tools...
May 8, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29731022/prediabetes
#4
REVIEW
Aditya K Khetan, Sanjay Rajagopalan
The burden of diabetes is expected to rise from 415 million individuals in 2015 to 642 million individuals by 2040. Most individuals pass through a phase of prediabetes before developing full-blown diabetes. Insulin resistance, impaired incretin action, and insulin hypersecretion are central to the pathophysiology of prediabetes. Individuals older than 40 years of age and other high-risk individuals should be screened for diabetes with fasting plasma glucose and/or hemoglobin A1c. For those diagnosed with prediabetes, the goal of treatment should be restoring euglycemia, because there are data showing that restoring normoglycemia during prediabetes and early diabetes can produce lasting remission...
May 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29722039/mortality-from-adverse-drug-reaction-related-hospitalizations-in-south-west-ethiopia-a-cross-sectional-study
#5
M T Angamo, L Chalmers, C M Curtain, D Yilma, L Bereznicki
WHAT IS KNOWN AND OBJECTIVE: Adverse drug reactions (ADRs) are an important cause of mortality during medical care. To our knowledge, no Ethiopian studies have reported on mortality due to ADRs in patients presenting to hospital from the community setting. The aim of this study was to determine the mortality rate attributable to ADRs in patients presenting to hospital, identify drugs implicated in the ADR-related deaths and identify factors contributing to ADR-related mortality at Jimma University Specialised Hospital (JUSH), south-west Ethiopia METHODS: This cross-sectional study included 1001 patients aged ≥18 years consecutively admitted to medical wards from May 2015 to August 2016...
May 2, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29695236/associations-between-comorbidities-their-treatment-and-survival-in-patients-with-interstitial-lung-diseases-a-claims-data-analysis
#6
Larissa Schwarzkopf, Sabine Witt, Julia Waelscher, Markus Polke, Michael Kreuter
BACKGROUND: Interstitial lung diseases (ILDs) are associated with a high burden of disease. However, data on the prognostic impact of comorbidities and comorbidity-related pharmaceutical treatments in patients with various ILDs remain sparse. METHODS: Using longitudinal claims data from a German Statutory Health Insurance Fund, we assessed comorbidity in ILD subtypes and associated drug treatments. Baseline comorbidity was assessed via the Elixhauser Comorbidity Index that was amended by ILD-relevant conditions...
April 25, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29694285/real-world-health-care-costs-based-on-medication-adherence-and-risk-of-stroke-and-bleeding-in-patients-treated-with-novel-anticoagulant-therapy
#7
Chinmay G Deshpande, Stephen Kogut, Cynthia Willey
BACKGROUND: With the lack of real-world evidence, the challenge for drug reimbursement policy decision makers is to understand medication adherence behavior among users of novel oral anticoagulants (NOACs) and its effect on overall cost savings. No study has examined and quantified the burden of cost in high-risk patients taking NOAC therapy. OBJECTIVE: To examine the association of cost with adherence, comorbidity, and risk of stroke and bleeding in patients taking NOACs (rivaroxaban and dabigatran)...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29683364/inflammatory-biomarkers-in-saliva-and-serum-of-patients-with-rheumatoid-arthritis-with-respect-to-periodontal-status
#8
Leena Äyräväinen, Anna Maria Heikkinen, Antti Kuuliala, Kirsi Ahola, Riitta Koivuniemi, Leena Laasonen, Eeva Moilanen, Mari Hämäläinen, Taina Tervahartiala, Jukka H Meurman, Marjatta Leirisalo-Repo, Timo Sorsa
OBJECTIVE: To study prospectively the association of salivary and serum matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1 and interleukin (IL)-6 with periodontal and systemic inflammation in rheumatoid arthritis (RA). We hypothesized that biomarker concentrations reflect inflammation. METHODS: 53 early untreated RA (ERA) and 28 chronic RA (CRA) patients, underwent rheumatological and dental examinations at baseline and one year later after starting first conventional or biological disease modifying antirheumatic drug...
April 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29682324/certolizumab-pegol-in-a-heterogeneous-population-of-patients-with-moderate-to-severe-rheumatoid-arthritis
#9
Enrique R Soriano, Analia Dellepiane, Gabriela Salvatierra, Cristian Alejandro Benítez, Rodrigo Garcia Salinas, Carlos Baruzzo
Aim: To determine the efficacy and safety of certolizumab pegol for the treatment of rheumatoid arthritis in a real-world setting. Materials & methods: Patients with moderate-to-severe rheumatoid arthritis who initiated therapy with certolizumab were followed for 12 weeks. Response was assessed with Disease Activity Score of 28 joints, European Ligue Against Rheumatism criteria and Simplified Disease Activity Index. Predictors of response were analyzed with binary logistic regression models...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29657613/relationship-between-physician-based-assessment-of-disease-activity-quality-of-life-and-costs-of-ulcerative-colitis-in-poland
#10
Paweł Kawalec, Ewa Stawowczyk
Introduction: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disorder, which requires lifelong treatment. It generates substantial direct and indirect costs, and significantly affects the quality of life, especially in the active state of the disease. Aim: To evaluate the direct and indirect costs of UC as well as to assess disease activity and quality of life reported by patients with UC in Polish settings. Material and methods: A questionnaire, cross-sectional study among UC patients as well as physicians involved in the therapy of the patients was conducted...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29644803/prevalence-risk-factors-and-adverse-outcomes-of-anticholinergic-burden-in-patients-with-advanced-chronic-conditions-at-hospital-admission
#11
Daniel Sevilla-Sánchez, Núria Molist-Brunet, Javier González-Bueno, Núria Solà-Bonada, Joan Espaulella-Panicot, Carles Codina-Jané
AIM: To evaluate the anticholinergic burden (ACB), the risk factors associated with its onset and the clinical consequences for patients with advanced chronic conditions. METHODS: A 10-month cross-sectional study was carried out in an acute hospital care geriatric unit. Patients with advanced chronic conditions were identified by the NECessity of PALliative care (NECPAL) test. The ACB was established using the Anticholinergic Drug Scale and Drug Burden Index (DBI) tools...
April 11, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29626047/risk-factors-and-biomarkers-of-non-alcoholic-fatty-liver-disease-an-observational-cross-sectional-population-survey
#12
Xiao-Yu Hu, Yun Li, Long-Quan Li, Yuan Zheng, Jia-Hong Lv, Shu-Chun Huang, Weinong Zhang, Liang Liu, Ling Zhao, Zhuiguo Liu, Xiu-Ju Zhao
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a major public health burden in China, and its prevalence is increasing. This study aimed to determine the risk factors and biomarkers of NAFLD. DESIGN: An observational cross-sectional primary survey. SETTING: Central China. PARTICIPANTS: The study included 1479 participants aged over 18 and below 80 years, not currently being treated for cancer or infectious disease or no surgery in the previous year, and no history of cancer or an infectious disease...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29624580/estimating-the-response-and-economic-burden-of-rheumatoid-arthritis-patients-treated-with-biologic-disease-modifying-antirheumatic-drugs-in-taiwan-using-the-national-health-insurance-research-database-nhird
#13
Qiang Shi, Ko-Jen Li, Tamas Treuer, Bruce C M Wang, Carol L Gaich, Chien-Hsun Lee, Wen-Shuo Wu, Wesley Furnback, Chao-Hsiun Tang
BACKGROUND: Previous studies in Taiwan utilizing the Taiwan's National Health Insurance Database (NHIRD) have estimated the direct healthcare costs of RA patients, but they have not focused on patients on bDMARDs, or considered patients' response to therapy. OBJECTIVES: The objective of this study was to estimate the rate of inadequate response for patients newly treated with biologic disease-modifying antirheumatic drugs (bDMARDs) as well as their costs and resource use...
2018: PloS One
https://www.readbyqxmd.com/read/29621245/study-on-essential-drug-use-status-and-its-influencing-factors-among-cerebral-infarction-inpatients-in-county-level-hospitals-of-anhui-province-china
#14
Cunhui Wang, Niannian Li, Heng Wang, Hongyan Yin, Yunwu Zhao
BACKGROUND AND PURPOSE: Drug costs is one of the main components of hospitalization expenditure for cerebral infarction inpatients. In China, the National Essential Medicine System (NEMS) was created to relieve the heavy drug-cost burden for patients. The objective of this study was to investigate essential drug-use status and its influencing factors among cerebral infarction inpatients in county-level hospitals of Anhui province, China. METHODS: Three county-level hospitals were selected through a multi-stage cluster random sampling method...
2018: PloS One
https://www.readbyqxmd.com/read/29618311/predicting-factors-affecting-glucose-monitoring-treatment-satisfaction-and-drug-attitude-inventory-adherence-among-patients-with-type-2-diabetes-mellitus-cross-sectional-observational-study
#15
Syed Ata Ur Rahman
OBJECTIVES: The study aimed to explore the predictors affecting patient satisfaction to glucose monitoring system (GMSS) and drug attitude inventory (DAI) / treatment adherence among type 2 diabetes mellitus patients. METHODS: Cross-sectional observational study design was used to conduct this study. Subjective assessments were made by questionnaires and objective data was collected from the patients' medication profiles registered to diabetic clinics. Patients were recruited from five different public hospitals of Hyderabad region, India...
April 4, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29602795/disease-modifying-drugs-for-multiple-sclerosis-and-infection-risk-a-cohort-study
#16
José Maria Andreas Wijnands, Feng Zhu, Elaine Kingwell, John David Fisk, Charity Evans, Ruth Ann Marrie, Yinshan Zhao, Helen Tremlett
OBJECTIVE: Little is known about disease-modifying treatments (DMTs) for multiple sclerosis (MS) and infection risk in clinical practice. We examined the association between DMTs and infection-related medical encounters. METHODS: Using population-based administrative data from British Columbia, Canada, we identified MS cases and followed them from their first demyelinating event (1996-2013) until emigration, death or study end (December 2013). Associations between DMT exposure (by DMT generation or class) and infection-related physician or hospital claims were assessed using recurrent time-to-events models, adjusted for age, sex, socioeconomic status, index year and comorbidity count...
March 30, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29590279/comparison-of-drug-discontinuation-effectiveness-and-safety-between-clinical-trial-eligible-and-ineligible-patients-in-badbir
#17
Kayleigh J Mason, Jonathan N W N Barker, Catherine H Smith, Philip J Hampton, Mark Lunt, Kathleen McElhone, Richard B Warren, Zenas Z N Yiu, Christopher E M Griffiths, A David Burden
Importance: Patients with psoriasis enrolled in clinical trials of biologics may not be representative of the real-world population. There is evidence that patients ineligible for such trials have a greater risk of serious adverse events (SAEs), but the effect on drug discontinuation and effectiveness are unknown. Objective: To determine whether (1) drug discontinuation, (2) effectiveness, and (3) rates of SAEs differ in patients with psoriasis categorized as eligible or ineligible for clinical trials...
March 28, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29589542/association-between-drug-burden-index-and-functional-and-cognitive-function-in-polypathological-patients-dbi-and-comorbidity
#18
Angela Mª Villalba-Moreno, Eva Rocio Alfaro-Lara, Aitana Rodriguez-Perez, Daniel Banez-Toro, Susana Sanchez-Fidalgo, Mª Concepcion Perez-Guerrero, Bernardo Santos-Ramos, Mª Dolores Nieto-Martin
BACKGROUND: Anticholinergic and sedative drugs are associated with adverse events such as cognitive and functional impairment in elderly. The Drug Burden Index (DBI) is a measure of an individual's total exposure to anticholinergic and sedative drugs. Objetive: To evaluate the association between the total DBI and cognitive and functional impairment in polypathological patients (PP). SETTING: Polypathological patients, enrolled in the IMPACTO project. METHODS: Cross-sectional observational study...
March 27, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29578852/economic-burden-of-patients-with-inadequate-response-to-targeted-immunomodulators-for-rheumatoid-arthritis
#19
Vibeke Strand, Namita Tundia, Yan Song, Dendy Macaulay, Mahesh Fuldeore
BACKGROUND: Targeted immunomodulators (TIMs), including biologic disease-modifying antirheumatic drugs (DMARDs) and JAK/STAT inhibitors, are effective therapies for rheumatoid arthritis (RA), but some patients fail to respond or lose response over time. This study estimated the real-world prevalence of RA patients with inadequate responses to an initial TIM (nonresponders) in the United States and assessed their direct and indirect economic burden compared with treatment responders. METHODS: Administrative claims data (January 1999-March 2014) from a large private-insurer database were used, which included work-loss data from a subset of reporting companies...
April 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29568735/outcomes-of-a-national-cohort-of-children-with-acute-severe-ulcerative-colitis
#20
Abisoye O Akintimehin, Ríoghnach Sinead O'Neill, Conor Ring, Tara Raftery, Séamus Hussey
Aim: All Irish children with ulcerative colitis (UC) attend the National Centre for Paediatric Gastroenterology at Our Lady's Children's Hospital, Crumlin. The aim of this study was to determine the outcomes of children with acute severe ulcerative colitis (ASC) and the impact of infliximab on these outcomes following its introduction for this indication in 2011. Methods: A retrospective chart review of all patients admitted with ASC between January 1, 2009 and December 31, 2015 was undertaken...
2018: Frontiers in Pediatrics
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