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https://www.readbyqxmd.com/read/28216624/dual-targeted-hybrid-nanoparticles-of-synergistic-drugs-for-treating-lung-metastases-of-triple-negative-breast-cancer-in-mice
#1
Tian Zhang, Preethy Prasad, Ping Cai, Chunsheng He, Dan Shan, Andrew Michael Rauth, Xiao Yu Wu
Lung metastasis is the major cause of death in patients with triple negative breast cancer (TNBC), an aggressive subtype of breast cancer with no effective therapy at present. It has been proposed that dual-targeted therapy, ie, targeting chemotherapeutic agents to both tumor vasculature and cancer cells, may offer some advantages. The present work was aimed to develop a dual-targeted synergistic drug combination nanomedicine for the treatment of lung metastases of TNBC. Thus, Arg-Gly-Asp peptide (RGD)-conjugated, doxorubicin (DOX) and mitomycin C (MMC) co-loaded polymer-lipid hybrid nanoparticles (RGD-DMPLN) were prepared and characterized...
February 20, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28210861/the-effects-of-alcoholism-and-smoking-on-advanced-cancer-patients-admitted-to-an-acute-supportive-palliative-care-unit
#2
Sebastiano Mercadante, Claudio Adile, Patrizia Ferrera, Alessandra Casuccio
AIM: The aim of this prospective study was to determine the characteristics and symptom burden of advanced cancer patients with alcoholism problems and smoking, who were referred to an acute palliative/supportive care unit (ASPCU) of a comprehensive cancer center. METHODS: Patients' characteristics, indications for admission, kind of admission, awareness of prognosis, and anticancer treatments were recorded. The Edmonton Symptom Assessment Scale (ESAS) was used to assess physical and psychological symptoms, and the CAGE questionnaire for the diagnosis of alcoholism...
February 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28208008/disability-due-to-inflammatory-bowel-disease-is-correlated-with-drug-compliance-disease-activity-and-quality-of-life
#3
Jin Young Yoon, Jeong Eun Shin, Sang Hyoung Park, Dong Il Park, Jae Myung Cha
Background/Aims: The inflammatory bowel disease disability index (IBD-DI) was recently developed for IBD to assess the functional consequences and disease burden. We applied the IBD-DI to a Korean population and identified predictive factors influencing IBD-related disability. Methods: Between March and August 2015, 322 consecutive patients with IBD were prospectively recruited. Patients completed the IBD-DI questionnaire and Crohn's and Ulcerative Colitis Questionnaire (CUCQ-8) for assessing quality of life...
February 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28199002/validating-the-shortened-quality-of-life-in-childhood-epilepsy-questionnaire-qolce-55-in-a-sample-of-children-with-drug-resistant-epilepsy
#4
Lauryn Conway, Elysa Widjaja, Mary Lou Smith, Kathy N Speechley, Mark A Ferro
OBJECTIVE: The aim of this study was to validate the newly developed shortened Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) in a sample of children with drug-resistant epilepsy. METHODS: Data came from 136 children enrolled in the Impact of Pediatric Epilepsy Surgery on Health-Related Quality of Life Study (PEPSQOL), a multicenter prospective cohort study. Confirmatory factor analysis was used to assess the higher-order factor structure of the QOLCE-55...
February 15, 2017: Epilepsia
https://www.readbyqxmd.com/read/28193651/in-vivo-pharmacodynamic-evaluation-of-omadacycline-ptk-0796-against-streptococcus-pneumoniae-in-the-murine-pneumonia-model
#5
Alexander J Lepak, Miao Zhao, Karen Marchillo, Jamie VanHecker, David R Andes
Omadacycline is a novel aminomethylcylcine antibiotic in clinical development for community acquired bacterial pneumonia (CABP). We used a neutropenic murine pneumonia infection model to characterize the in vivo pharmacodynamic activity of omadacycline against Streptococcus pneumoniae Four strains with varying phenotypic resistance to other antimicrobials including tetracyclines were utilized. Drug concentration measurements were performed in the plasma and epithelial lining fluid (ELF) after administration of 0...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28111133/meglumine-ant%C3%A4-moniate-tio2-ag-nanoparticle-combinations-reduce-toxicity-of-the-drug-while-enhancing-its-antileishmanial-effect
#6
Emrah Sefik Abamor, Adil M Allahverdiyev, Melahat Bagirova, Miriam Rafailovich
Currently, the treatment of leishmaniasis is increasingly insufficient as current antileishmanial drugs have many disadvantages such as toxic side effects, high cost, and growing drug resistance. In order to overcome these disadvantages, researchers have recently focused on combination therapy by using pentavalent antimonials in conjunction with other antileihmanial compounds. Our previous study found that TiO2@Ag nanoparticles (TiAgNps) demonstrated significant antileishmanial effects. However, a lethal dose of TiAgNps on L...
January 19, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28109056/impact-of-completeness-of-revascularization-in-complex-coronary-artery-disease-as-measured-with-the-syntax-revascularization-index-an-seeds-substudy
#7
Bo Xu, Nicolas Bettinger, Changdong Guan, Björn Redfors, Yuejin Yang, Bao Li, Yaling Han, Xi Su, Zuyi Yuan, Philippe Généreux
OBJECTIVES: We sought to study whether the level of completeness of revascularization as measured by the SYNTAX revascularization index (SRI) independently predicts adverse ischemic events after percutaneous coronary intervention (PCI) with second-generation drug-eluting stents (DES). BACKGROUND: The SRI quantifies the proportion of revascularized myocardium. It has been shown to independently predict adverse ischemic events after PCI with first-generation DES. METHODS: Among 1,900 patients enrolled in a registry to evaluate safety and effectiveness of everolimus drug-eluting stent (SEEDS) for coronary revascularization, the SRI was calculated and available for 1,851 patients...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28103601/superiority-in-quality-of-life-improvement-of-biologics-over-conventional-systemic-drugs-in-a-swiss-real-life-psoriasis-registry
#8
Pierre Jungo, Julia-Tatjana Maul, Vahid Djamei, Stefanie von Felten, Antonios G A Kolios, Justine Czernielewsk, Nikhil Yawalkar, Olivia Odermatt, Emmanuel Laffitte, Mark Anliker, Markus Streit, Matthias Augustin, Curdin Conrad, Jürg Hafner, Wolf-Henning Boehncke, Michel Gilliet, Peter Itin, Lars E French, Alexander A Navarini, Peter Häusermann
BACKGROUND: Randomized controlled trials have shown the efficacy of systemic treatments in moderate-to-severe psoriasis. Clinical outcomes in psoriasis patients under real-world conditions are less well understood. OBJECTIVE: This study compared Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI) improvement in all psoriasis patients registered in the Swiss Dermatology Network for Targeted Therapies. We asked whether outcomes differed between 4 treatment strategies, namely biologic monotherapy versus conventional systemic monotherapy, versus combined biologic and conventional systemic drugs, and versus therapy adaptation (switching from one type to another)...
January 20, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28050395/variation-of-cost-among-anti-cancer-drugs-available-in-indian-market
#9
Bhanu Prakash Kolasani, Divyashanthi Chellathambi Malathi, Raghunatha Rao Ponnaluri
INTRODUCTION: Although cancer remains a major health problem all over the world, its treatment is limited by affordability of patients in a developing country like India. Information generated from cost analysis studies will be helpful for both the doctors in choosing the correct medicine for their patients and also for policy makers in successfully utilizing the meager resources that are available. AIM: The aim of the present observational study was to analyse the price variations of anti-cancer drugs available in India...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28026898/factors-associated-with-changes-in-exposure-to-anticholinergic-and-sedative-medications-in-elderly-hospitalized-patients-multicentre-longitudinal-study
#10
V Dauphinot, R Faure, L Bourguignon, S Goutelle, P Krolak-Salmon, C Mouchoux
BACKGROUND AND PURPOSE: Elderly patients exposed to drugs with anticholinergic or sedative properties may have an increased risk of adverse events. This study aimed to assess the relationship between patient characteristics and changes of exposure to anticholinergic and sedative medications during their hospital stay. METHODS: A multicentre longitudinal study was set up on hospitalized patients (aged ≥65 years) using at least one drug at admission. The primary outcome was change of exposure to anticholinergic and sedative drugs between admission and discharge...
December 27, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28007635/pharmaid-study-protocol-randomized-controlled-trial-to-assess-the-impact-of-integrated-pharmaceutical-care-at-a-psychosocial-intervention-on-caregiver-s-burden-in-alzheimer-s-disease-or-related-diseases
#11
T Novais, C Moutet, F Delphin-Combe, V Dauphinot, C Colin, P Krolak-Salmon, C Mouchoux
INTRODUCTION: Alzheimer's Disease and Related Diseases (ADRD) are associated with a caregiver burden that increases with the progression of the disease. Psychosocial interventions reported a moderate improvement on caregivers' burden. Patients with ADRD and their older caregivers are also exposed to a higher risk of developing drug-related problems. The main objective of the PHARMAID study is to measure the impact of personalized pharmaceutical collaborative care integrated to a multidisciplinary psychosocial program on the burden of caregivers...
February 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27990512/warfarin-genotyping-with-hybridization-induced-aggregation-on-a-poly-ethylene-terephthalate-microdevice
#12
Hillary S Sloane, Morgan B Carter, Alexa E C Cecil, Delphine Le Roux, Daniel L Mills, James P Landers
Warfarin, a commonly prescribed oral anticoagulant, is burdened by a narrow therapeutic index and high inter-individual variability in response, making it the second leading cause of drug-related emergency room visits. Since genetic factors contribute significantly to warfarin sensitivity, a genotype-guided dosing strategy may reduce the occurrence of adverse events. While numerous methods have been demonstrated for warfarin genotyping, the specifications of most assays with respect to turnaround time and cost are not ideal for routine testing...
December 19, 2016: Analyst
https://www.readbyqxmd.com/read/27987565/economic-burden-of-deep-infiltrating-endometriosis-of-the-bowel-and-the-bladder-in-germany-the-statutory-health-insurance-perspective
#13
Katharina C Koltermann, Andreas Schlotmann, Helmut Schröder, Stefan N Willich, Thomas Reinhold
BACKGROUND: Until now, there has been little discussion of the costs of the deep infiltrating endometriosis (DIE) of the bowel or the bladder. The aim of the present secondary data analysis was to describe the population affected by this disease and to determine the economic burden in Germany from a payer's perspective. METHODS: Health claims data of women diagnosed with DIE of the bladder or bowel, who were surgically treated as inpatients between Jan 1, 2008 and Dec 31, 2012, were evaluated retrospectively...
December 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/27971647/patterns-of-index-biologic-drug-registrations-to-a-pharmacovigilance-register-of-psoriasis-patients
#14
K J Mason, I Evans, K McElhone, M Lunt, S Hussain, B Kirby, A Burden, N J Reynolds, C E Griffiths
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27955664/the-burden-of-hypertension-diabetes-mellitus-and-cardiovascular-risk-factors-among-adult-malawians-in-hiv-care-consequences-for-integrated-services
#15
Oscar H Divala, Alemayehu Amberbir, Zahra Ismail, Teferi Beyene, Daniela Garone, Colin Pfaff, Victor Singano, Harriet Akello, Martias Joshua, Moffat J Nyirenda, Alfred Matengeni, Josh Berman, Jane Mallewa, Gift S Chinomba, Noel Kayange, Theresa J Allain, Adrienne K Chan, Sumeet K Sodhi, Joep J van Oosterhout
BACKGROUND: Hypertension and diabetes prevalence is high in Africans. Data from HIV infected populations are limited, especially from Malawi. Integrating care for chronic non-communicable co-morbidities in well-established HIV services may provide benefit for patients by preventing multiple hospital visits but will increase the burden of care for busy HIV clinics. METHODS: Cross-sectional study of adults (≥18 years) at an urban and a rural HIV clinic in Zomba district, Malawi, during 2014...
December 12, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27909739/quantification-of-anticholinergic-and-sedative-drug-load-with-the-drug-burden-index-a-review-of-outcomes-and-methodological-quality-of-studies
#16
REVIEW
Hans Wouters, Helene van der Meer, Katja Taxis
PURPOSE: The Drug Burden Index (DBI) is a non-invasive method to quantify patients' anticholinergic and sedative drug burden from their prescriptions. This systematic review aimed to summarise the evidence on the associations between the DBI and clinical outcomes and methodological quality of studies. METHODS: A search in PubMed and Embase (search terms: 'drug', 'burden', and 'index') was performed and experts were contacted. We excluded publications that did not report empirical results or clinical outcomes...
December 1, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27904656/the-berlin-treatment-algorithm-recommendations-for-tailored-innovative-therapeutic-strategies-for-multiple-sclerosis-related-fatigue
#17
REVIEW
Christian Veauthier, Helge Hasselmann, Stefan M Gold, Friedemann Paul
More than 80% of multiple sclerosis (MS) patients suffer from fatigue. Despite this, there are few therapeutic options and evidence-based pharmacological treatments are lacking. The associated societal burden is substantial (MS fatigue is a major reason for part-time employment or early retirement), and at least one out of four MS patients view fatigue as the most burdensome symptom of their disease. The mechanisms underlying MS-related fatigue are poorly understood, and objective criteria for distinguishing and evaluating levels of fatigue and tiredness have not yet been developed...
2016: EPMA Journal
https://www.readbyqxmd.com/read/27901222/workload-and-associated-factors-a-study-in-maritime-port-in-brazil
#18
Marta Regina Cezar-Vaz, Clarice Alves Bonow, Marlise Capa Verde de Almeida, Cynthia Fontella Sant'Anna, Leticia Silveira Cardoso
Objective: to identify the effect of the mental, physical, temporal, performance, total effort and frustration demands in the overall workload, and in the same way analyze the global burden of port labor and associated factors that contribute most to their decrease or increase. Method: a cross-sectional, quantitative study, developed with 232 dock workers. For data collection, a structured questionnaire with descriptive, occupational, smoking and illicit drug use variables was applied, as well as variables on the load on the tasks undertaken at work, based on the questionnaire NASA Task Load Index...
November 28, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27899145/bibliometric-analysis-of-publications-on-campylobacter-2000-2015
#19
Waleed M Sweileh, Samah W Al-Jabi, Ansam F Sawalha, Adham S AbuTaha, Sa'ed H Zyoud
BACKGROUND: Campylobacter species are widespread zoonotic pathogens. Campylobacter jejuni causes a form of gastroenteritis called campylobacteriosis. Campylobacter drug resistance is considered a serious threat. In order to better understand national and international research output on Campylobacter, we conducted this bibliometric overview of publications on Campylobacter. This study can be used to assess extent of interaction and response of researchers, food regulators, and health policy makers to global burden of campylobacateriosis...
November 29, 2016: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/27890573/pegylated-oleic-acid-a-promising-amphiphilic-polymer-for-nano-antibiotic-delivery
#20
Calvin A Omolo, Rahul S Kalhapure, Mahantesh Jadhav, Sanjeev Rambharose, Chunderika Mocktar, Valence M K Ndesendo, Thirumala Govender
Vancomycin (VM), a last resort to control methicillin-resistant S. aureus (MRSA) infections, is on the verge of becoming ineffective. Novel nano delivery systems of VM have the potential to combat MRSA. The search for novel materials for nanoantibiotic development is therefore an active research area. In this study, oleic acid (OA) was coupled with monomethoxy polyethylene glycol (mPEG) to obtain a novel bio-safe amphiphilic polymer, mPEG-OA. The critical micelle concentration of mPEG-OA, was found to be 4...
November 23, 2016: European Journal of Pharmaceutics and Biopharmaceutics
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