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https://www.readbyqxmd.com/read/28918441/long-lasting-subjective-effects-of-lsd-in-normal-subjects
#1
Yasmin Schmid, Matthias E Liechti
RATIONALE: Lysergic acid diethylamide (LSD) and other serotonergic hallucinogens can induce profound alterations of consciousness and mystical-type experiences, with reportedly long-lasting effects on subjective well-being and personality. METHODS: We investigated the lasting effects of a single dose of LSD (200 μg) that was administered in a laboratory setting in 16 healthy participants. The following outcome measures were assessed before and 1 and 12 months after LSD administration: Persisting Effects Questionnaire (PEQ), Mysticism Scale (MS), Death Transcendence Scale (DTS), NEO-Five Factor Inventory (NEO-FFI), and State-Trait Anxiety Inventory (STAI)...
September 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28917612/thyroid-stimulating-hormone-anti-thyroid-antibodies-and-pregnancy-outcomes
#2
Torie C Plowden, Enrique F Schisterman, Lindsey A Sjaarda, Neil J Perkins, Robert Silver, Rose Radin, Keewan Kim, Noya Galai, Alan H DeCherney, Sunni L Mumford
BACKGROUND: Overt thyroid dysfunction has been associated with adverse obstetrical outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications. OBJECTIVE: To examine the association between pre-pregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery (PTD), gestational diabetes (GDM), and preeclampsia. STUDY DESIGN: Secondary analysis of a prospective cohort of 18-40 year old women with 1-2 prior pregnancy losses (n=1193) participating in a multi-center randomized, placebo-controlled trial of low-dose aspirin...
September 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28915919/project-lifeskills-a-randomized-controlled-efficacy-trial-of-a-culturally-tailored-empowerment-based-and-group-delivered-hiv-prevention-intervention-for-young-transgender-women-study-protocol
#3
Lisa M Kuhns, Matthew J Mimiaga, Sari L Reisner, Katie Biello, Robert Garofalo
BACKGROUND: Transgender women in the U.S. have an alarmingly high incidence rate of HIV infection; condomless anal and vaginal sex is the primary risk behavior driving transmission. Young transgender women are the subpopulation at the highest risk for HIV. Despite this, there are no published randomized controlled efficacy trials testing interventions to reduce sexual risk for HIV among this group. This paper describes the design of a group-based intervention trial to reduce sexual risk for HIV acquisition and transmission in young transgender women...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28903730/routine-monitoring-and-assessment-of-adults-living-with-hiv-results-of-the-british-hiv-association-bhiva-national-audit-2015
#4
A Molloy, H Curtis, F Burns, A Freedman
BACKGROUND: The clinical care of people living with HIV changed fundamentally as a result of the development of effective antiretroviral therapy (ART). HIV infection is now a long-term treatable condition. We report a national audit to assess adherence to British HIV Association guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals. METHODS: All UK sites known as providers of adult HIV outpatient services were invited to complete a case-note review and a brief survey of local clinic practices...
September 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28882121/evaluation-of-a-peer-education-program-on-student-leaders-energy-balance-related-behaviors
#5
B C Foley, V A Shrewsbury, L L Hardy, V M Flood, K Byth, S Shah
BACKGROUND: Few studies have reported energy balance-related behavior (EBRB) change for peer leaders delivering health promotion programs to younger students in secondary schools. Our study assessed the impact of the Students As LifeStyle Activists (SALSA) program on SALSA peer leaders' EBRBs, and their intentions regarding these behaviors. METHODS: We used a pre-post study design to assess changes in EBRBs and intentions of Year 10 secondary school students (15-16 year olds) who volunteered to be peer leaders to deliver the SALSA program to Year 8 students (13-14 year olds)...
September 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28879070/trends-in-breast-and-colorectal-cancer-screening-among-u-s-adults-by-race-healthcare-coverage-and-ses-before-during-and-after-the-great-recession
#6
Taylor E Wyatt, Vikash Pernenkil, Tomi F Akinyemiju
The aim of this study is examine trends in breast and colorectal cancer screening in the U.S. by race, healthcare coverage, and socio-economic status (SES) before the Great Recession (2003-2005), during the recession (2007-2009), and post-recession/Affordable Care Act (ACA) period (2010 - 2012). Data on a representative sample of U.S. adults was obtained from the Behavioral Risk Factor Surveillance System (BRFSS). Breast and colorectal cancer screening were defined in line with U.S. Preventative Services Task Force guidelines, and survey weighted statistical methods were utilized to analyze trends in cancer screening among 1,858,572 BRFSS participants...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28870800/cancer-pain-with-a-neuropathic-component-a-cross-sectional-study-of-its-clinical-characteristics-associated-psychological-distress-treatments-and-predictors-at-referral-to-a-cancer-pain-clinic
#7
Paulo Reis-Pina, Anand Acharya, Peter G Lawlor
CONTEXT: In patients with cancer pain, identifying a neuropathic pain component (NPC) may inform the selection of subsequent therapeutic interventions. OBJECTIVES: To determine the prevalence, clinical characteristics, associated psychological distress, pre-referral treatment, and predictors of cancer pain with a NPC in patients referred to a cancer pain clinic. METHODS: Participants had standard assessments and documentation: Brief Pain Inventory ratings; presence of a NPC, based on a DN4 (neuropathic pain screening scale) score ≥4 combined with a physician's clinical assessment (blinded to DN4 result); the Hospital Anxiety Depression Scale (HADS) and Emotional Thermometer scores...
September 1, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28870159/obstetric-professionals-perceptions-of-non-invasive-prenatal-testing-for-down-syndrome-clinical-usefulness-compared-with-existing-tests-and-ethical-implications
#8
Olivia Miu Yung Ngan, Huso Yi, Samuel Yeung Shan Wong, Daljit Sahota, Shenaz Ahmed
BACKGROUND: While non-invasive prenatal testing (NIPT) for fetal aneuploidy is commercially available in many countries, little is known about how obstetric professionals in non-Western populations perceive the clinical usefulness of NIPT in comparison with existing first-trimester combined screening (FTS) for Down syndrome (DS) or invasive prenatal diagnosis (IPD), or perceptions of their ethical concerns arising from the use of NIPT. METHODS: A cross-sectional survey among 327 obstetric professionals (237 midwives, 90 obstetricians) in Hong Kong...
September 5, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28868990/the-effects-of-whole-body-vibration-on-pulse-wave-velocity-in-men-with-chronic-spinal-cord-injury
#9
Julia O Totosy de Zepetnek, Masae Miyatani, Maggie Szeto, Lora M Giangregorio, B Catharine Craven
Objective A pilot study to evaluate the therapeutic potential of 40 weeks of passive standing with whole body vibration (PS-WBV) on central and peripheral arterial stiffness among men with chronic spinal cord injury (SCI). Methods Consenting participants were pre-screened to ensure safe participation. Fifteen individuals with chronic SCI were enrolled to participate in PS-WBV sessions three times per week for 40 weeks on a modified WAVE platform custom-fitted with an EASYStand 5000. Knee angle was set at 160°, and vibration parameters were 45Hz frequency and 0...
September 4, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28868806/validity-of-maximum-isometric-tongue-pressure-as-a-screening-test-for-physical-frailty-cross-sectional-study-of-japanese-community-dwelling-older-adults
#10
Hirotomo Yamanashi, Yuji Shimizu, Miho Higashi, Jun Koyamatsu, Shimpei Sato, Mako Nagayoshi, Koichiro Kadota, Shinya Kawashiri, Mami Tamai, Noboru Takamura, Takahiro Maeda
AIM: Maximum isometric tongue pressure (MIP) seems to have a diagnostic value for oral phase dysphagia. The present study aimed to examine the association between MIP and frailty, and to assess the screening validity of MIP for physical frailty. METHODS: We carried out a cross-sectional study, and enrolled participants aged ≥60 years from Japanese national medical check-ups in 2015 and 2016. The Fried frailty phenotype model was used. We analyzed odds ratios (OR) and 95% confidence intervals (CI) of physical frailty using one standard deviation increments of tongue pressure...
September 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28862483/prep-chicago-a-randomized-controlled-peer-change-agent-intervention-to-promote-the-adoption-of-pre-exposure-prophylaxis-for-hiv-prevention-among-young-black-men-who-have-sex-with-men
#11
Lindsay E Young, Phil Schumm, Leigh Alon, Alida Bouris, Matthew Ferreira, Brandon Hill, Aditya S Khanna, Thomas W Valente, John A Schneider
BACKGROUND/AIMS: Advances in biomedical prevention strategies such as pre-exposure prophylaxis (PrEP) represent a new opportunity for reducing HIV incidence among young Black men who have sex with men, for whom the number of new HIV infections continues to rise. However, studies have documented low rates of PrEP uptake in this community. Research suggests that the peer networks of young Black men who have sex with men play important roles in their sexual health decisions. PrEP Chicago is a randomized controlled trial network intervention designed to increase PrEP uptake among young Black men who have sex with men living in Chicago...
September 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28857850/interventions-to-improve-hand-hygiene-compliance-in-the-icu-a-systematic-review
#12
Sinéad Lydon, Michael Power, Jennifer McSharry, Molly Byrne, Caoimhe Madden, Janet Elaine Squires, Paul O'Connor
OBJECTIVES: To synthesize the literature describing interventions to improve hand hygiene in ICUs, to evaluate the quality of the extant research, and to outline the type, and efficacy, of interventions described. DATA SOURCES: Systematic searches were conducted in November 2016 using five electronic databases: Medline, CINAHL, PsycInfo, Embase, and Web of Science. Additionally, the reference lists of included studies and existing review papers were screened. STUDY SELECTION: English language, peer-reviewed studies that evaluated an intervention to improve hand hygiene in an adult ICU setting, and reported hand hygiene compliance rates collected via observation, were included...
August 28, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28855962/does-child-and-adolescent-mental-health-in-service-training-result-in-equivalent-knowledge-gain-among-cadres-of-non-specialist-health-workers-in-uganda-a-pre-test-post-test-study
#13
Angela Akol, Joyce Nalugya, Sylvia Nshemereirwe, Juliet N Babirye, Ingunn Marie Stadskleiv Engebretsen
BACKGROUND: Early identification and management of child and adolescent mental health (CAMH) disorders helps to avert mental illness in adulthood but a CAMH treatment gap exists in Uganda. CAMH integration into primary health care (PHC) through in-service training of non-specialist health workers (NSHW) using the World Health Organisation (WHO) Mental Health Gap Action Programme (mhGAP) Intervention Guide (IG) is a strategy to address this gap. However, results of such training are not supported by information on training development or delivery; and are undifferentiated by NSHW cadre...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28855163/does-aerobic-exercise-reduce-postpartum-depressive-symptoms-a-systematic-review-and-meta-analysis
#14
Ruth Victoria Pritchett, Amanda J Daley, Kate Jolly
BACKGROUND: There is currently no specific guidance on the role of exercise in managing postpartum depression in the UK and US, and international guidance is inconsistent. AIM: To assess the effectiveness of aerobic exercise on postpartum depressive symptoms. DESIGN AND SETTING: Systematic review and meta-analysis. There was no restriction to study site or setting. METHOD: The databases MEDLINE, EMBASE, Cochrane Library, PsycINFO, SportDiscus, Clinical Trials...
August 30, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28853612/foot-problems-in-older-adults-associations-with-incident-falls-frailty-syndrome-and-sensor-derived-gait-balance-and-physical-activity-measures
#15
Amy Muchna, Bijan Najafi, Christopher S Wendel, Michael Schwenk, David G Armstrong, Jane Mohler
BACKGROUND: Research on the relationship between foot problems and frailty is sparse and could be elucidated via advances in wearable sensor-based measures of gait, balance, and physical activity (PA). This study examined the impact of foot problems on likelihood of falls, frailty syndrome, motor performance, and PA in community-dwelling older adults. METHODS: Arizona Frailty Cohort Study participants (community-dwelling adults 65 years and older without baseline cognitive deficit, severe movement disorders, or recent stroke) underwent Fried frailty and foot assessment...
August 30, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28841910/the-hiv-care-cascade-from-hiv-diagnosis-to-viral-suppression-in-sub-saharan-africa-a-systematic-review-and-meta-regression-analysis-protocol
#16
Aysel Gueler, Fiona Vanobberghen, Brian Rice, Matthias Egger, Catrina Mugglin
BACKGROUND: In 2014, UNAIDS announced the 90-90-90 treatment targets to curb the HIV epidemic by 2020: 90% of people living with HIV know their HIV status, 90% of people who know their HIV status access treatment and 90% of people on treatment have suppressed viral loads. Monitoring and evaluation are needed to track linkage and retention throughout the continuum of care. We propose a systematic review and meta-regression to identify the different methodological approaches used to define the steps in the HIV care cascade in sub-Saharan Africa (SSA), where most people with HIV live, and to assess the proportion of participants retained at each step...
August 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28837757/systemic-antibiotics-for-treating-malignant-wounds
#17
REVIEW
Darshini A Ramasubbu, Valerie Smith, Fiona Hayden, Patricia Cronin
BACKGROUND: Malignant wounds are a devastating complication of cancer. They usually develop in the last six months of life, in the breast, chest wall or head and neck regions. They are very difficult to treat successfully, and the commonly associated symptoms of pain, exudate, malodour, and the risk of haemorrhage are extremely distressing for those with advanced cancer. Treatment and care of malignant wounds is primarily palliative, and focuses on alleviating pain, controlling infection and odour from the wound, managing exudate and protecting the surrounding skin from further deterioration...
August 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28833626/cardiac-imaging-to-detect-coronary-artery-disease-in-athletes-aged-35-years-and-older-a-scoping-review
#18
Thijs L Braber, Johannes B Reitsma, Arend Mosterd, Martin J Willemink, Niek H J Prakken, Martin Halle, Sanjay Sharma, Birgitta K Velthuis
Sudden cardiac death (SCD) is a devastating event in athletes. Screening efforts that were first directed at athletes younger than 35 years, are now focusing on the rapidly growing group of older sportspersons. Athletes aged ≥35 years have a 10-fold increased risk of exercise-related cardiac arrest, mostly due to coronary artery disease (CAD). Although cardiac imaging is pivotal in identifying CAD, the role of imaging modalities in screening asymptomatic older sportspersons remains unclear. We performed a scoping review to identify the role of cardiac imaging to detect CAD in older sportspersons and to identify gaps in the existing literature...
August 23, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28832980/nationwide-skin-cancer-screening-in-germany-evaluation-of-the-training-program
#19
Markus P Anders, Susanne Fengler, Beate Volkmer, Rüdiger Greinert, Eckhard W Breitbart
BACKGROUND: In July 2008, the German statutory health insurance introduced a nationwide skin cancer screening program. Before the introduction, eligible physicians had to qualify to perform the screening test and counsel their patients on skin cancer screening. To educate physicians, a curriculum and training materials were developed. Since 2015 a revised curriculum and training materials have been used. The purpose of this paper is to provide information about the curriculum and to evaluate the revised training program...
August 18, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28832755/assessment-in-the-primary-care-of-the-state-of-s%C3%A3-o-paulo-brazil-incipient-actions-in-sexual-and-reproductive-health
#20
Mariana Arantes Nasser, Maria Ines Battistella Nemes, Marta Campagnoni Andrade, Rogério Ruscitto do Prado, Elen Rose Lodeiro Castanheira
OBJECTIVE: The objective of this study is to assess performance in sexual and reproductive health of primary health care services of the Brazilian Unified Health System, in the State of São Paulo, Brazil. METHODS: An evaluative framework was built for sexual and reproductive health with the categorization of 99 indicators in three domains: sexual and reproductive health promotion (25), sexually transmitted infections/AIDS prevention and care (43), and reproductive health care (31)...
August 17, 2017: Revista de Saúde Pública
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