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https://www.readbyqxmd.com/read/28212466/withdrawn-propranolol-for-migraine-prophylaxis
#1
REVIEW
Klaus Linde, Karin Rossnagel
BACKGROUND: Propranolol is one of the most commonly prescribed drugs for migraine prophylaxis. OBJECTIVES: We aimed to determine whether there is evidence that propranolol is more effective than placebo and as effective as other drugs for the interval (prophylactic) treatment of patients with migraine. SEARCH METHODS: Potentially eligible studies were identified by searching MEDLINE/PubMed (1966 to May 2003) and the Cochrane Central Register of Controlled Trials (Issue 2, 2003), and by screening bibliographies of reviews and identified articles...
February 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28206871/swallowing-therapy-and-progressive-resistance-training-in-head-and-neck-cancer-patients-undergoing-radiotherapy-treatment-randomized-control-trial-protocol-and-preliminary-data
#2
Sara F Hajdú, Irene Wessel, Christoffer Johansen, Claus A Kristensen, Zahra T Kadkhoda, Christina C Plaschke, Susanne O Dalton
BACKGROUND: Head and neck cancer (HNC) patients are often challenged by treatment induced dysphagia and trismus. Traditionally, rehabilitation is initiated when loss of function has already occurred. There is increasing evidence that it is of benefit to patients to initiate an early rehabilitation process before and during treatment. HNC patients have a unique set of functional challenges such as pre- and post-treatment dysphagia, pain and weight loss. The aim of the trial is to investigate the effects of swallowing and mouth-opening exercises combined with progressive resistance training (PRT) during radiotherapy...
February 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28193509/pilot-study-analyzing-automated-ecg-screening-of-hypertrophic-cardiomyopathy
#3
Matthew Campbell, Xuefu Zhou, Chia Han, Hedayat Abrishami, Gregory Webster, Christina Y Miyake, Christopher T Sower, Jeffery B Anderson, Timothy K Knilans, Richard J Czosek
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is one of the leading causes of sudden cardiac death in athletes. However, pre-participation ECG screening has often been criticized for failing to meet cost-effectiveness thresholds, in part because of high false-positive rates and the cost of ECG screening itself. OBJECTIVES: To assess the testing characteristics of an automated ECG algorithm designed to screen for HCM in a multi-institutional pediatric cohort. METHODS: ECGs from patients with HCM aged 12 - 20 years from 3 pediatric institutions were screened for ECG criteria for HCM using a previously described automated computer algorithm developed specifically for HCM ECG screening...
February 10, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28192460/knowledge-attitudes-practices-and-willingness-to-vaccinate-in-preparation-for-the-introduction-of-hpv-vaccines-in-bamako-mali
#4
Anne S De Groot, Karamoko Tounkara, Mali Rochas, Sarah Beseme, Shahla Yekta, Fanta Siby Diallo, J Kathleen Tracy, Ibrahima Teguete, Ousmane A Koita
Although screening for pre-cancerous cervical lesions and human papilloma virus (HPV) vaccination are accepted and effective means to prevent cervical cancer, women in Mali have limited access to these interventions. In addition, cervical cancer prevention by HPV vaccination has been controversial in some settings. To reduce cervical cancer prevalence and increase HPV vaccine uptake, it is important to understand the level of knowledge about cervical cancer screening and practices related to vaccination in at-risk populations...
2017: PloS One
https://www.readbyqxmd.com/read/28186444/the-diagnostic-accuracy-of-myocardial-perfusion-scintigraphy-in-athletes-with-abnormal-exercise-test-results
#5
Danny Ajp van de Sande, Ing Han Liem, Jan Hoogsteen, Hareld Mc Kemps
Background Previous studies revealed a relatively high prevalence of electrocardiographic findings indicative for myocardial ischemia in asymptomatic athletes undergoing pre-participation screening. Myocardial perfusion scintigraphy is generally considered a valuable diagnostic and prognostic modality and often used for further diagnostic evaluation in these subjects. However, data on the diagnostic accuracy of myocardial perfusion scintigraphy in athletes are scarce. Objectives The main purpose of this study was to investigate the positive predictive value of myocardial perfusion scintigraphy for detection of coronary artery disease in asymptomatic athletes with abnormal exercise testing results during pre-participation screening...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28185891/feasibility-of-a-telehealth-educational-program-on-self-management-of-pain-and-fatigue-in-adult-cancer-patients
#6
Gabrielle B Rocque, Karina I Halilova, Allyson L Varley, Courtney P Williams, Richard A Taylor, David G Masom, William J Wright, Edward E Partridge, Elizabeth A Kvale
BACKGROUND: Pain and fatigue are common symptoms among cancer patients and often lead to substantial distress. Innovative self-management programs for pain and fatigue are needed. OBJECTIVES: The primary objective was to assess the feasibility of a telehealth pain and fatigue self-management program among adult cancer patients. Secondary objectives included assessment of differences in patient characteristics, recruitment and retention of patients based on 2 screening strategies: (1) navigator-collected, patient-reported pain or fatigue and (2) in-clinic, physician-identified pain or fatigue...
February 6, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28180146/-i-think-we-ve-got-too-many-tests-prenatal-providers-reflections-on-ethical-and-clinical-challenges-in-the-practice-integration-of-cell-free-dna-screening
#7
B L Gammon, S A Kraft, M Michie, M Allyse
BACKGROUND: The recent introduction of cell-free DNA-based non-invasive prenatal screening (cfDNA screening) into clinical practice was expected to revolutionize prenatal testing. cfDNA screening for fetal aneuploidy has demonstrated higher test sensitivity and specificity for some conditions than conventional serum screening and can be conducted early in the pregnancy. However, it is not clear whether and how clinical practices are assimilating this new type of testing into their informed consent and counselling processes...
July 2016: Ethics, Medicine, and Public Health
https://www.readbyqxmd.com/read/28177959/interprofessional-medical-legal-education-of-medical-students-assessing-the-benefits-for-addressing-social-determinants-of-health
#8
Robert Pettignano, Lisa Bliss, Susan McLaren, Sylvia Caley
PROBLEM: Screening tools exist to help identify patient issues related to social determinants of health (SDH), but solutions to many of these problems remain elusive to health care providers as they require legal solutions. Interprofessional medical-legal education is essential to optimizing health care delivery. APPROACH: In 2011, the authors implemented a four-session didactic interprofessional curriculum on medical-legal practice for third-year medical students at Morehouse School of Medicine...
February 7, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28177746/preliminary-safety-analysis-of-high-intensity-interval-training-hiit-in-persons-with-chronic-stroke
#9
Daniel L Carl, Pierce Boyne, Bradley Rockwell, Myron Gerson, Jane Khoury, Brett Kissela, Kari Dunning
The purpose of this study was to assess safety via electrocardiographic (ECG), blood pressure (BP), heart rate (HR), and orthopedic responses to 3 different high-intensity interval training (HIIT) protocols in persons with stroke. Eighteen participants (10 male; 61.9 + 8.3 years of age; 5.8 + 4.2 years poststroke) completed a symptom-limited graded exercise test (GXT) with ECG monitoring to screen for eligibility and determine HR peak. The 3 HIIT protocols involved repeated 30 s bursts of treadmill walking at maximum speed alternated with rest periods of 30 s (P30), 1 min (P60), or 2 min (P120)...
November 21, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28171696/predicting-changes-in-adaptive-functioning-and-behavioral-adjustment-following-treatment-for-a-pediatric-brain-tumor-a-report-from-the-brain-radiation-investigative-study-consortium
#10
Kristen R Hoskinson, Kelly R Wolfe, Keith Owen Yeates, E Mark Mahone, Kim M Cecil, M Douglas Ris
OBJECTIVE: Children are at risk for behavioral and adaptive difficulties following pediatric brain tumor. This study explored whether familial/demographic, developmental, diagnostic, or treatment-related variables best predict post-treatment behavioral and adaptive functioning. METHODS: Participants included 40 children (mean age = 12.76 years, SD = 4.01) post-treatment (mean time since diagnosis = 1.99 years, SD = 0.21) for pediatric brain tumor...
February 7, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28168512/automated-oscillometric-blood-pressure-and-pulse-wave-acquisition-for-evaluation-of-vascular-stiffness-in-atherosclerosis
#11
Alexander Massmann, Jennifer Stemler, Peter Fries, Reinhard Kubale, Lutz Erwin Kraushaar, Arno Buecker
OBJECTIVE: Evaluation of diagnostic accuracy of an oscillometry-based device (VascAssist) combining fully automated ankle-brachial index (ABI) and pulse-wave velocity (PWV) assessment for detection of peripheral arterial disease (PAD). SUBJECTS AND METHODS: 110 consecutive subjects including symptomatic PAD patients (n = 41) and healthy PAD-free participants (n = 69) were recruited. All subjects underwent standard manual Doppler-based ABI (sABI) and oscillometry-based automated ABI (aABI) measurements (VascAssist)...
February 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28166521/rationale-and-design-of-a-clinical-trial-investigating-tolvaptan-safety-and-efficacy-in-autosomal-dominant-polycystic-kidney-disease
#12
Vicente E Torres, Olivier Devuyst, Arlene B Chapman, Ron T Gansevoort, Ronald D Perrone, John Ouyang, Jaime D Blais, Frank S Czerwiec, Olga Sergeyeva
BACKGROUND: In TEMPO 3:4, the vasopressin V2-receptor antagonist tolvaptan slowed kidney growth and function decline in autosomal dominant polycystic kidney disease (ADPKD) patients with relatively preserved kidney function. METHODS: Prospective, phase 3b, multi-center, randomized-withdrawal, placebo-controlled, double-blind trial of tolvaptan in ADPKD patients with late stage 2 to early stage 4 chronic kidney disease (CKD). The primary endpoint was estimated glomerular filtration rate (eGFR) change from pre-treatment baseline to post-treatment follow-up...
February 7, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28165766/longitudinal-assessment-of-the-edinburgh-cognitive-and-behavioural-amyotrophic-lateral-sclerosis-screen-ecas-lack-of-practice-effect-in-als-patients
#13
Christian Burkhardt, Christoph Neuwirth, Markus Weber
OBJECTIVE: The study objective was to assess whether controls and ALS patients show a practice effect in the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) on repeated longitudinal testing and if the ECAS detects progression of cognitive or behavioural changes over time. METHODS: The ECAS was administered serially to ALS patients (n = 24 after six months, n = 10 after 12-18 months) and controls (n = 21 after six months). The ECAS was fully performed by all participants...
February 6, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28164494/the-blood-bank-for-diabetes-screening-a-feasible-alternative
#14
Mauren I Anghebem-Oliveira, Claudia D Costa, Giorgio R Baldanzi, Juliane C Schmitt-Mansur, Geraldo Picheth, Fabiane G M Rego
BACKGROUND: Vascular complications of diabetes mellitus (DM) are associated with 5% of deaths globally every year. Early diagnosis and treatment could reduce this figure. The aim of this project was to investigate the frequency of undiagnosed DM among blood donors and the possibility of blood banks participating in DM screening. METHODS: Of the approximate 5,600 candidates for blood donation who were evaluated, 4,601 were considered suitable. Candidates with any type of DM, hypertension, thyroid disease, and/or continuous use of any drugs were excluded, resulting in the participation of 635 donors aged 18 - 69 years...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28161455/pre-migration-and-post-migration-factors-associated-with-mental-health-in-humanitarian-migrants-in-australia-and-the-moderation-effect-of-post-migration-stressors-findings-from-the-first-wave-data-of-the-bnla-cohort-study
#15
Wen Chen, Brian J Hall, Li Ling, Andre Mn Renzaho
BACKGROUND: The process of becoming a humanitarian migrant is potentially damaging to mental health. We examined the association between pre-migration and post-migration potentially traumatic events and stressors and mental health, and assessed the moderating effect of post-migration stressors in humanitarian migrants in Australia. METHODS: In this study, we used the first wave of data between 2013 and 2014 from the Building a New Life in Australia survey. The survey included 2399 migrants who had arrived in Australia holding a permanent humanitarian visa 3-6 months preceding the survey, with 77% and 23% of participants being granted visas through offshore and onshore humanitarian programmes, respectively...
February 1, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28161199/use-of-a-digital-modified-checklist-for-autism-in-toddlers-revised-with-follow-up-to-improve-quality-of-screening-for-autism
#16
Kathleen Campbell, Kimberly L H Carpenter, Steven Espinosa, Jordan Hashemi, Qiang Qiu, Mariano Tepper, Robert Calderbank, Guillermo Sapiro, Helen L Egger, Jeffrey P Baker, Geraldine Dawson
OBJECTIVES: To assess changes in quality of care for children at risk for autism spectrum disorders (ASD) due to process improvement and implementation of a digital screening form. STUDY DESIGN: The process of screening for ASD was studied in an academic primary care pediatrics clinic before and after implementation of a digital version of the Modified Checklist for Autism in Toddlers - Revised with Follow-up with automated risk assessment. Quality metrics included accuracy of documentation of screening results and appropriate action for positive screens (secondary screening or referral)...
February 1, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28159337/normal-computerized-q-wave-measurements-in-healthy-young-athletes
#17
Divakar Saini, Aaron F Grober, David Hadley, Victor Froelicher
BACKGROUND: Recent Expert consensus statements have sought to decrease false positive rates of electrocardiographic abnormalities requiring further evaluation when screening young athletes. These statements are largely based on traditional ECG patterns and have not considered computerized measurements. OBJECTIVE: To define the normal limits for Q wave measurements from the digitally recorded ECGs of healthy young athletes. METHODS: All athletes were categorized by sex and level of participation (high school, college, and professional), and underwent screening ECGs with routine pre-participation physicals, which were electronically captured and analyzed...
January 16, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28156449/patient-reported-benefits-of-massage-therapy-as-treatment-for-chemotherapy-related-pain
#18
Alejandro Ramon Carvajal, Regina Cobb, Tanmay Sahai, Diane D'Ambra, Kathi Healey, Maria Soriano-Pisaturo
: 192 Background: Massage Therapy (MT) has been suggested to provide symptom relief of chemotherapy related side effects. Its impact on pain improvement, prevention, and overall quality of life (QoL) is characterized in this study and 2 different pain scales are being compared. METHODS: Patients who were on active chemotherapy and agreed to receive at least one MT session over a 10-week period were included. Wong-Baker Pain scale (WBPS) and Numerical Pain Scale (NPS) were assessed pre and post every session...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152984/rationale-for-and-design-of-the-posta-study-evaluation-of-neurocognitive-outcomes-after-immediate-adenotonsillectomy-compared-to-watchful-waiting-in-preschool-children
#19
Karen A Waters, Jasneek Chawla, Margaret-Anne Harris, Carolyn Dakin, Helen Heussler, Robert Black, Alan Cheng, Hannah Burns, John D Kennedy, Kurt Lushington
BACKGROUND: IQ deficits are linked to even mild obstructive sleep apnoea (OSA) in children. Although OSA is commonly first diagnosed in the pre-school age group, a randomised trial is still needed to assess IQ outcomes after adenotonsillectomy in the pre-school age-group. This randomised control trial (RCT) will primarily determine whether adenotonsillectomy improves IQ compared to no adenotonsillectomy after 12 months, in preschool (3-5 year-old) children with mild to moderate OSA. METHODS: This protocol is for an ongoing multi-centred RCT with a recruitment target of 210 subjects (105 in each arm)...
February 2, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28152855/cervical-screening-reminder-calls-pilot-utilizing-emrs-to-improve-cancer-screening
#20
Aaron Randall
: 163 Background: Cancer screening detects pre-cancerous changes, or cancer at an early stage when there is a better chance of treating it successfully. Research shows that that physician encouragement improves the odds of patients getting screened. Furthermore, systematic reviews demonstrate that efforts to encourage screening can be more effective through telephone reminders when compared to other methods of outreach. Electronic Medical Records (EMRs) are a powerful tool for the coordination, recording, monitoring and reporting of patient care in primary care...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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