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https://www.readbyqxmd.com/read/27486139/hyperplastic-stomatitis-and-esophagitis-in-a-tortoise-testudo-graeca-associated-with-an-adenovirus-infection
#1
Beatriz Garcia-Morante, Judit J Pénzes, Taiana Costa, Jaime Martorell, Jorge Martínez
A 2-year-old female, spur-thighed tortoise (Testudo graeca) was presented with poor body condition (1/5) and weakness. Fecal analysis revealed large numbers of oxyurid-like eggs, and radiographs were compatible with gastrointestinal obstruction. Despite supportive medical treatment, the animal died. At gross examination, an intestinal obstruction was confirmed. Histopathology revealed severe hyperplastic esophagitis and stomatitis with marked epithelial cytomegaly and enormous basophilic intranuclear inclusion bodies...
September 2016: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27105145/tlr9-1486t-c-and-2848c-t-snps-are-associated-with-human-cytomegalovirus-infection-in-infants
#2
Edyta Paradowska, Agnieszka Jabłońska, Mirosława Studzińska, Katarzyna Skowrońska, Patrycja Suski, Małgorzata Wiśniewska-Ligier, Teresa Woźniakowska-Gęsicka, Dorota Nowakowska, Zuzanna Gaj, Jan Wilczyński, Zbigniew J Leśnikowski
Toll-like receptor 9 (TLR9) recognizes non-methylated viral CpG-containing DNA and serves as a pattern recognition receptor that signals the presence of human cytomegalovirus (HCMV). Here, we present the genotype distribution of single-nucleotide polymorphisms (SNPs) of the TLR9 gene in infants and the relationship between TLR9 polymorphisms and HCMV infection. Four polymorphisms (-1237T/C, rs5743836; -1486T/C, rs187084; 1174G/A, rs352139; and 2848C/T, rs352140) in the TLR9 gene were genotyped in 72 infants with symptomatic HCMV infection and 70 healthy individuals...
2016: PloS One
https://www.readbyqxmd.com/read/26559848/trehalose-an-mtor-independent-inducer-of-autophagy-inhibits-human-cytomegalovirus-infection-in-multiple-cell-types
#3
Jean-Philippe Belzile, Maite Sabalza, Megan Craig, Elizabeth Clark, Christopher S Morello, Deborah H Spector
UNLABELLED: Human cytomegalovirus (HCMV) is the major viral cause of birth defects and a serious problem in immunocompromised individuals and has been associated with atherosclerosis. Previous studies have shown that the induction of autophagy can inhibit the replication of several different types of DNA and RNA viruses. The goal of the work presented here was to determine whether constitutive activation of autophagy would also block replication of HCMV. Most prior studies have used agents that induce autophagy via inhibition of the mTOR pathway...
November 11, 2015: Journal of Virology
https://www.readbyqxmd.com/read/25844529/tlr9-2848-ga-heterozygotic-status-possibly-predisposes-fetuses-and-newborns-to-congenital-infection-with-human-cytomegalovirus
#4
Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Zuzanna Gaj, Jan Wilczyński, Zbigniew Leśnikowski, Dorota Nowakowska
BACKGROUND: Some single nucleotide polymorphisms (SNP), located in Toll-like receptor (TLR) genes, were reported to be associated with human cytomegalovirus (HCMV) infections. The study was aimed to assess the correlation of SNPs at TLR4 and TLR9 genes with the occurrence of congenital cytomegaly, based on available samples. METHODS: Reported case-control study included both HCMV infected and non-infected fetuses and newborns. The specimens were classified to the molecular analyses, based on serological features of the recent infection and HCMV DNAemia in body fluids...
2015: PloS One
https://www.readbyqxmd.com/read/25813912/severe-cytomegalovirus-infection-in-a-second-kidney-transplant-recipient-treated-with-ganciclovir-leflunomide-and-immunoglobulins-with-complications-including-seizures-acute-hcv-infection-drug-induced-pancytopenia-diabetes-cholangitis-and-multi-organ-failure
#5
Dorota Miszewska-Szyszkowska, Natalia Mikołajczyk, Ewa Komuda-Leszek, Renata Wieczorek-Godlewska, Robert Świder, Dominika Dęborska-Materkowska, Jacek Szmidt, Magdalena Durlik
BACKGROUND: Cytomegaly remains one of the most common infectious complications in organ transplant recipients, and the course of the infection may have a negative effect on survival of the transplant and recipient. CASE REPORT: We describe the case of a 32-year-old female patient who received a second kidney transplant from a cadaveric donor in July 2012, treated successfully with ganciclovir for primary CMV infection in August 2012 and then re-treated from November due to re-infection...
2015: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/25752146/-age-related-changes-in-the-rat-lacrimal-gland-specific-morphology-and-unknown-nature
#6
REVIEW
O S Gancharova, V N Manskikh
The rat lacrimal apparatus includes several glands; among them, the exorbital gland plays the central role. Its parenchyma and stroma undergo prominent morphologic changes with age. The parenchymal transformation includes metaplasia of some of its acini and their turning into Harderian gland-like structures (harderization), accumulation of gland ducts ("ductularization"), and morphologic dysplasia-cytomegaly, karyomegaly, and'cell and nuclearpolymorphism in the other part of acini. All these transformations are hormone-dependent andsex-specific: theyoften appear in males...
September 2014: Ontogenez
https://www.readbyqxmd.com/read/25568137/tenofovir-disoproxil-fumarate-toxicity-toxicokinetics-and-toxicogenomics-analysis-after-13-weeks-of-oral-administration-in-mice
#7
Hanna H Ng, Howard Stock, Linda Rausch, Deborah Bunin, Abraham Wang, Shirley Brill, Jason Gow, Jon C Mirsalis
Tenofovir disoproxil fumarate (TDF) is a prodrug of tenofovir that exhibits activity against HIV and hepatitis B. The goals of this study were to evaluate the molecular mechanism of TDF-induced toxicity in mice after 13 weeks of daily oral administration (50-1000 mg/kg) by correlating transcriptional changes with plasma drug levels and traditional toxicology end points. Plasma levels and systemic exposure of tenofovir increased less than dose proportionally and were similar on days 1 and 91. No overt toxicity was observed following the completion of TDF administration...
January 2015: International Journal of Toxicology
https://www.readbyqxmd.com/read/25536573/peculiarities-of-viruses-herpesviridae-family-persistence-in-patients-with-non-alcoholic-fatty-liver-disease-who-had-been-exposed-to-the-factors-of-chornobyl-npp-accident
#8
A A Chumak, O V Nosach, L M Ovsyannikova, S M Alekhina, O Ya Pleskach, E O Sarkisova, O V Gasanova, T O Shyiko, L P Tyupa
Objective - to define the features of viruses persistence belonging to the Herpesviridae family in patients with non-alcoholic fatty liver disease (NAFLD) who had been exposed to the factors of Chornobyl NPP accident. Material and methods. The main group included 45 male NAFLD patients sufferers of Chornobyl NPP accident with absorbed doses of external irradiation in the range of 10-580 mSv. The group of nosology comparison consisted of 20 male NAFLD patients with the doses of irradiation within the limits of natural radiation background and regulated doses of medical irradiation...
September 2014: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/25348608/mixed-infections-with-distinct-cytomegalovirus-glycoprotein-b-genotypes-in-polish-pregnant-women-fetuses-and-newborns
#9
M Rycel, W Wujcicka, B Zawilińska, E Paradowska, P Suski, Z Gaj, J Wilczyński, Z Leśnikowski, D Nowakowska
The purpose of this investigation was to describe a distribution of cytomegalovirus (CMV) single and multiple genotypes among infected pregnant women, their fetuses, and newborns coming from Central Poland, as well as congenital cytomegaly outcome. The study involved 278 CMV-seropositive pregnant women, of whom 192 were tested for viral DNAemia. Human cytomegalovirus (HCMV) genotyping was performed for 18 of 34 pregnant women carrying the viral DNA and for 12 of their 15 offspring with confirmed HCMV infections...
March 2015: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/25194351/sclerosing-paraganglioma-of-the-carotid-body-a-potential-pitfall-of-malignancy
#10
Raffaella Santi, Alessandro Franchi, Valeria Saladino, Massimo Trovati, Giovanna Cenacchi, Massimo Squadrelli-Saraceno, Gabriella Nesi
Paragangliomas (PGs) of the head and neck region are typically benign, slow-growing neuroendocrine tumours. At times, they may exhibit unusual histological features, such as prominent stromal sclerosis (sclerosing PG), which may raise concerns of malignancy. We describe a case of sclerosing PG of the carotid body, emphasizing the value of immunohistochemical stains for differential diagnosis. A 43-year-old woman presented with a painless lump on the neck. A magnetic resonance imaging scan demonstrated a hypervascular lesion of the carotid body, which was surgically excised...
June 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/24908921/congenital-optic-disc-cyst-concomitant-with-persistent-hyaloid-artery-a-case-report
#11
Monika Modrzejewska, Ewelina Lachowicz, Ewa Tokarz-Sawińska, Wojciech Lubiński, Adam Koryzma, Anna Walecka, Tomasz Urasiński, Stanisław Zajaczek
The aim is to present a rare case of solitary malformation in the form of a congenital optic disc cyst concomitant with the persistent hyaloid artery. The intrabulbar congenital cyst of the optic disc partially covering the medial part of the disc was found in a 3-month old infant. B-San ultrasound confirmed the presence of the intrabulbar heterogeneous mass (7.0 x 2.5 x 5.4 mm) within the vitreous cavity and the concomitant persistent hyaloid artery was shown in Colour Doppler Imaging. The axial length of the involved eye was shorter than of the healthy one (16...
2013: Klinika Oczna
https://www.readbyqxmd.com/read/24902519/impact-of-socioeconomic-risk-factors-on-the-seroprevalence-of-cytomegalovirus-infections-in-a-cohort-of-pregnant-polish-women-between-2010-and-2011
#12
W Wujcicka, Z Gaj, J Wilczyński, W Sobala, E Spiewak, D Nowakowska
The purpose of this investigation was to perform an evaluation of the prevalence and socioeconomic risk factors for human cytomegalovirus (HCMV) infections in a cohort of Polish pregnant women between 2010 and 2011. HCMV-specific IgG and IgM antibody levels were assayed with enzyme-linked immunosorbent assay (ELISA) tests in serum samples collected from 1,250 pregnant women attending outpatient obstetric clinics and hospitalized at two hospitals in Lodz. The seroprevalence of anti-HCMV IgG and IgM antibodies was 62...
November 2014: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/24865775/immunohistochemical-expression-of-caspase-3-caspase-5-caspase-7-and-apoptotic-protease-activating-factor-1-apaf-1-in-the-liver-and-kidney-of-rats-exposed-to-zoledronic-acid-zol-and-basic-fibroblast-growth-factor-bfgf
#13
Ahmet Aydogan, Gulperi Kocer, Ozlem Ozmen, Murat Kocer, Levent Onal, Ozgur Koskan
BACKGROUND: Bisphosphonates (BPs) like zoledronic acid (ZOL) are widely used for the treatment of different diseases such as osteoporosis, metastatic bone diseases and hypercalcaemia. However, the effects of BPs on apoptosis of the liver and kidney after treatment are unclear. Furthermore, basic fibroblast growth factor (bFGF) is an angiogenic molecule, which plays an important role in angiogenesis and tissue repair. The present study investigated the expression of caspase-3, -5, -7 and apoptotic protease-activating factor-1 (APAF-1) in the liver and kidney of rats treated with ZOL and bFGF...
2014: Veterinary Quarterly
https://www.readbyqxmd.com/read/24675088/an-integrated-characterization-of-serological-pathological-and-functional-events-in-doxorubicin-induced-cardiotoxicity
#14
Laura Cove-Smith, Neil Woodhouse, Adam Hargreaves, Jason Kirk, Susan Smith, Sally A Price, Melanie Galvin, Catherine J Betts, Simon Brocklehurst, Alison Backen, John Radford, Kim Linton, Ruth A Roberts, Matthias Schmitt, Caroline Dive, Jonathan D Tugwood, Paul D Hockings, Howard R Mellor
Many efficacious cancer treatments cause significant cardiac morbidity, yet biomarkers or functional indices of early damage, which would allow monitoring and intervention, are lacking. In this study, we have utilized a rat model of progressive doxorubicin (DOX)-induced cardiomyopathy, applying multiple approaches, including cardiac magnetic resonance imaging (MRI), to provide the most comprehensive characterization to date of the timecourse of serological, pathological, and functional events underlying this toxicity...
July 2014: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/24505947/-evaluation-of-the-association-between-maternal-hcmv-viremia-and-the-course-of-pregnancy-and-neonatal-outcome
#15
Magdalena Rycel, Zuzanna Gaj, Jan Wilczyński, Edyta Paradowska, Mirosława Studzińska, Patrycja Suski, Dorota Nowakowska
UNLABELLED: Congenital cytomegaly is caused by intrauterine mother-to-fetus HCMV transmission and constitutes the most common vertical infection. OBJECTIVES: The aim of the study was to analyze the viremia level in maternal blood and its influence on the course and duration of pregnancy as well as newborn condition. MATERIAL AND METHODS: The material included blood samples collected from 117 pregnant women with serological features of HCMV infection and from 29 neonates hospitalized at DFMMG in Lodz between 1999 and 2009...
December 2013: Ginekologia Polska
https://www.readbyqxmd.com/read/24457689/34-unusual-association-or-rare-differentiation-follicular-lymphoma-and-plasmacytoma
#16
Gabriel Scripcaru, Stephen Lade, Ross Stillwell
BACKGROUND AND AIM: Isolated intranodal plasmacytomas are rare, but well described. When appearing as a localised neoplastic process they tend to have a favourable prognosis, in particular when IgA secreting. Follicular lymphomas with plasma cell or plasmacytoid differentiation are even less common, but also sporadically encountered in practice and the literature. We present a unique case in which the two entities are associated. RESULTS: This is the case of a 42-year-old who presented with isolated node lymphadenopathy in the submandibular area...
February 2014: Pathology
https://www.readbyqxmd.com/read/24088187/bk-viremia-and-polyomavirus-nephropathy-in-352-kidney-transplants-risk-factors-and-potential-role-of-mtor-inhibition
#17
Johannes Jacobi, Antonina Prignitz, Maike Büttner, Klaus Korn, Alexander Weidemann, Karl F Hilgers, Katharina Heller, Joachim Velden, Antje Knöll, Bernd Wullich, Christoph May, Kai-Uwe Eckardt, Kerstin U Amann
BACKGROUND: Polyomavirus BK nephropathy (PyVAN) remains an important cause of early graft dysfunction and graft loss in kidney transplantation. METHODS: In this retrospective, single centre cohort study we studied the incidence and outcome of BK viral infection in 352 patients transplanted in 2008-2011. RESULTS: During follow-up viral replication was detected in 48 patients (13.6%); 22 patients (6.2%) had biopsy proven PyVAN.In multivariate logistic regression analyses risk factors for BK-viremia were lack of enrolment into randomized controlled trials (RCTs), biopsy proven acute rejections, cytomegaly virus (CMV) serostatus of both donor and recipient and previous transplantation...
2013: BMC Nephrology
https://www.readbyqxmd.com/read/23973933/hirmi-valley-liver-disease-a-disease-associated-with-exposure-to-pyrrolizidine-alkaloids-and-ddt
#18
Oliver Robinson, Elizabeth Want, Muireann Coen, Ruth Kennedy, Catharina van den Bosch, Yohannes Gebrehawaria, Hiromi Kudo, Fouzia Sadiq, Robert D Goldin, Michael L Hauser, Alan Fenwick, Mireille B Toledano, Mark R Thursz
BACKGROUND & AIMS: Hirmi Valley liver disease was first reported in 2001 in Tigray, Ethiopia. 591 cases, including 228 deaths, were reported up to December 2009. The pyrrolizidine alkaloid acetyllycopsamine was detected in stored grain and residents reported adding the pesticide DDT (dichlorodiphenyldichloroethylene) directly to their food stores. We aimed to characterise the clinical features of the disease, and explore the role of these chemicals in its aetiology. METHODS: 32 cases were examined and full clinical histories taken...
January 2014: Journal of Hepatology
https://www.readbyqxmd.com/read/23961711/histologic-changes-in-the-adrenal-gland-reflect-fetal-distress-in-hydrops-fetalis
#19
Mana Taweevisit, Tawin Atikankul, Paul Scott Thorner
The distribution of lipid in the fetal adrenal cortex is reported to correlate with the duration of hypoxia and degree of fetal stress. The original studies were based on Oil Red O staining, requiring frozen tissue that is often not available. To investigate the reliability of these observations, the distribution of lipid in the fetal adrenal cortex was studied in hydrops fetalis (HF) of different etiologies, using immunostaining for adipophilin on formalin-fixed material. Twenty cases of HF due to hemoglobin (Hb) Bart were compared to 34 cases of HF due to other causes...
May 2014: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/23892008/focal-malformations-of-cortical-development-new-vistas-for-molecular-pathogenesis
#20
REVIEW
K-C Lim, P B Crino
Focal malformations of cortical development (FMCD) are highly associated with several neurological disorders including intractable epilepsy and neurocognitive disabilities. Over the past decade, several FMCD subtypes have been linked to hyperactivation of the mammalian target of rapamycin (mTOR) signaling cascade. In view of the roles that mTOR plays in cell proliferation, size, motility, and stem cell phenotype, many of the features of FMCD such as cytomegaly, disorganized lamination, and expression of stem cell markers can be explained by enhanced mTOR signaling...
November 12, 2013: Neuroscience
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