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https://www.readbyqxmd.com/read/28802165/the-world-according-to-garp-transcription-factors
#1
REVIEW
Alaeddine Safi, Anna Medici, Wojciech Szponarski, Sandrine Ruffel, Benoît Lacombe, Gabriel Krouk
Plant specific GARP transcription factor family (made of ARR-B and G2-like) contains genes with very diverse in planta functions: nutrient sensing, root and shoot development, floral transition, chloroplast development, circadian clock oscillation maintenance, hormonal transport and signaling. In this work we review: first, their structural but distant relationships with MYB transcription factors, second, their role in planta, third, the diversity of their Cis-regulatory elements, fourth, their potential protein partners...
August 10, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28795730/role-of-garp-in-the-activation-of-latent-tgf-%C3%AE-1
#2
REVIEW
Julie Stockis, Olivier Dedobbeleer, Sophie Lucas
TGF-β1, 2 and 3 cytokines are involved in many cellular processes including cell proliferation, differentiation, migration and survival. Whereas TGF-β2 and 3 play important roles in embryonic development, TGF-β1 is mostly implicated in controlling immune responses after birth. The production of TGF-β1 is a tightly regulated process, occurring mostly at a post-translational level. Virtually all cells produce the latent, inactive form of TGF-β1. In latent TGF-β1, the mature TGF-β1 dimer is non-covalently associated to the Latency Associated Peptide, or LAP, which prevents binding to the TGF-β1 receptor...
August 10, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28763790/platelets-subvert-t-cell-immunity-against-cancer-via-garp-tgf%C3%AE-axis
#3
Saleh Rachidi, Alessandra Metelli, Brian Riesenberg, Bill X Wu, Michelle H Nelson, Caroline Wallace, Chrystal M Paulos, Mark P Rubinstein, Elizabeth Garrett-Mayer, Mirko Hennig, Daniel W Bearden, Yi Yang, Bei Liu, Zihai Li
Cancer-associated thrombocytosis has long been linked to poor clinical outcome, but the underlying mechanism is enigmatic. We hypothesized that platelets promote malignancy and resistance to therapy by dampening host immunity. We show that genetic targeting of platelets enhances adoptive T cell therapy of cancer. An unbiased biochemical and structural biology approach established transforming growth factor β (TGFβ) and lactate as major platelet-derived soluble factors to obliterate CD4(+) and CD8(+) T cell functions...
May 5, 2017: Science Immunology
https://www.readbyqxmd.com/read/28758108/blood-transcriptional-signatures-for-disease-progression-in-a-rat-model-of-osteoarthritis
#4
Michał Korostyński, Natalia Małek, Marcin Piechota, Katarzyna Starowicz
Biomarkers of osteoarthritis (OA) that can accurately diagnose the disease at the earliest stage would significantly support efforts to develop treatments for prevention and early intervention. We have sought to determine the time course of alterations in peripheral blood gene expression profile associated with the development of OA. Blood samples were collected from a tail vein of individual rats with monosodium iodoacetate- (MIA-) induced OA (2, 14, 21, and 28 days after the treatment). We used whole-genome microarrays to reveal OA-related transcriptional alterations of 72 transcripts...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28658628/the-garp-complex-is-involved-in-intracellular-cholesterol-transport-via-targeting-npc2-to-lysosomes
#5
Jian Wei, Ying-Yu Zhang, Jie Luo, Ju-Qiong Wang, Yu-Xia Zhou, Hong-Hua Miao, Xiong-Jie Shi, Yu-Xiu Qu, Jie Xu, Bo-Liang Li, Bao-Liang Song
Proper intracellular cholesterol trafficking is critical for cellular function. Two lysosome-resident proteins, NPC1 and NPC2, mediate the egress of low-density lipoprotein-derived cholesterol from lysosomes. However, other proteins involved in this process remain largely unknown. Through amphotericin B-based selection, we isolated two cholesterol transport-defective cell lines. Subsequent whole-transcriptome-sequencing analysis revealed two cell lines bearing the same mutation in the vacuolar protein sorting 53 (Vps53) gene...
June 27, 2017: Cell Reports
https://www.readbyqxmd.com/read/28634332/predicting-the-potential-risk-area-of-illegal-vaccine-trade-in-china
#6
Yilan Liao, Yanhui Lei, Zhoupeng Ren, Huiyan Chen, Dongyue Li
Since the disclosure of the "Illegal vaccine operation series case in Jinan, Shandong" in March, 2016, this issue has attracted a great deal of attention and has led to public concerns about the safety and efficacy of the vaccines involved in this case. The main purpose of this paper is to scientifically and scrupulously predict the possible geographic distribution of illegal vaccines in China, and provide a foundation to guide future governmental policies and actions. A species distribution model was used because of the advantages of using presence/pseudo-absence or presence-only data, and it performs well with incomplete species distribution data...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619958/monocytes-inhibit-nk-activity-via-tgf-%C3%AE-in-patients-with-obstructive-sleep-apnoea
#7
Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Victor Toledano, Rebeca Pérez de Diego, Isabel Fernández-Navarro, Raquel Casitas, Carlos Carpio, Jose Casas-Martín, Jaime Valentín, Anibal Varela-Serrano, Jose Avendaño-Ortiz, Enrique Alvarez, Luis A Aguirre, Antonio Pérez-Martínez, Maria P De Miguel, Cristobal Belda-Iniesta, Francisco García-Río, Eduardo López-Collazo
Obstructive sleep apnoea (OSA) is associated with cancer incidence and mortality. The contribution of the immune system appears to be crucial; however, the potential role of monocytes and natural killer (NK) cells remains unclear.Quantitative reverse transcriptase PCR, flow cytometry and in vitro assays were used to analyse the phenotype and immune response activity in 92 patients with OSA (60 recently diagnosed untreated patients and 32 patients after 6 months of treatment with continuous positive airway pressure (CPAP)) and 29 healthy volunteers (HV)...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28607112/cutting-edge-active-tgf-%C3%AE-1-released-from-garp-tgf-%C3%AE-1-complexes-on-the-surface-of-stimulated-human-b-lymphocytes-increases-class-switch-recombination-and-production-of-iga
#8
Olivier Dedobbeleer, Julie Stockis, Bas van der Woning, Pierre G Coulie, Sophie Lucas
Production of active TGF-β is regulated at a posttranslational level and implies release of the mature cytokine dimer from the inactive, latent TGF-β precursor. There are several cell-type specific mechanisms of TGF-β activation. We identified a new mechanism operating on the surface of human regulatory T cells and involving membrane protein GARP, which binds latent TGF-β1. The paracrine activity of regulatory T cell-derived TGF-β1 contributes to immunosuppression and can be inhibited with anti-GARP Abs...
July 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28542518/rnf41-interacts-with-the-vps52-subunit-of-the-garp-and-earp-complexes
#9
Delphine Masschaele, Leentje De Ceuninck, Joris Wauman, Dieter Defever, Frank Stenner, Sam Lievens, Frank Peelman, Jan Tavernier
RNF41 (Ring Finger Protein 41) is an E3 ubiquitin ligase involved in the intracellular sorting and function of a diverse set of substrates. Next to BRUCE and Parkin, RNF41 can directly ubiquitinate ErbB3, IL-3, EPO and RARα receptors or downstream signaling molecules such as Myd88, TBK1 and USP8. In this way it can regulate receptor signaling and routing. To further elucidate the molecular mechanism behind the role of RNF41 in intracellular transport we performed an Array MAPPIT (Mammalian Protein-Protein Interaction Trap) screen using an extensive set of proteins derived from the human ORFeome collection...
2017: PloS One
https://www.readbyqxmd.com/read/28521960/yeast-dynamin-associates-with-the-garp-tethering-complex-for-endosome-to-golgi-traffic
#10
Uma Saimani, Jared Smothers, Hyoeun McDermott, Pelin Makaraci, Kyoungtae Kim
Yeast dynamin, Vacuolar Protein Sorting 1 (Vps1), has been implicated in recycling traffic from the endosome to the trans-Golgi network (TGN). Previous research showed a genetic interaction of Vps1 with all components of the GARP tethering complex, which anchors vesicles at the late Golgi membrane. We used the yeast two-hybrid system and have identified a 33 amino acid segment of Vps51, a GARP subunit, that interacts with Vps1. Based on sequence homology between Vps51 and its mammalian homolog Ang2 in the 33 amino acids stretch, we identified two key residues of Vps51, E127 and Y129, that bind Vps1...
May 8, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28495729/cancer-immunotherapy-according-to-garp
#11
EDITORIAL
Angela Colmone
No abstract text is available yet for this article.
May 12, 2017: Science
https://www.readbyqxmd.com/read/28340594/species-specific-ecological-niche-modelling-predicts-different-range-contractions-for-lutzomyia-intermedia-and-a-related-vector-of-leishmania-braziliensis-following-climate-change-in-south-america
#12
Shannon McIntyre, Elizabeth F Rangel, Paul D Ready, Bruno M Carvalho
BACKGROUND: Before 1996 the phlebotomine sand fly Lutzomyia neivai was usually treated as a synonym of the morphologically similar Lutzomyia intermedia, which has long been considered a vector of Leishmania braziliensis, the causative agent of much cutaneous leishmaniasis in South America. This report investigates the likely range changes of both sand fly species in response to a stabilisation climate change scenario (RCP4.5) and a high greenhouse gas emissions one (RCP8.5). METHODS: Ecological niche modelling was used to identify areas of South America with climates currently suitable for each species, and then the future distributions of these climates were predicted based on climate change scenarios...
March 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28331092/monkeypox-virus-host-factor-screen-using-haploid-cells-identifies-essential-role-of-garp-complex-in-extracellular-virus-formation
#13
Susan Realegeno, Andreas S Puschnik, Amrita Kumar, Cynthia Goldsmith, Jillybeth Burgado, Suryaprakash Sambhara, Victoria A Olson, Darin Carroll, Inger Damon, Tetsuya Hirata, Taroh Kinoshita, Jan E Carette, Panayampalli Subbian Satheshkumar
Monkeypox virus (MPXV) is a human pathogen that is a member of the Orthopoxvirus genus, which includes Vaccinia virus and Variola virus (the causative agent of smallpox). Human monkeypox is considered an emerging zoonotic infectious disease. To identify host factors required for MPXV infection, we performed a genome-wide insertional mutagenesis screen in human haploid cells. The screen revealed several candidate genes, including those involved in Golgi trafficking, glycosaminoglycan biosynthesis, and glycosylphosphatidylinositol (GPI)-anchor biosynthesis...
June 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28325841/an-inducible-amphipathic-helix-within-the-intrinsically-disordered-c-terminus-can-participate-in-membrane-curvature-generation-by-peripherin-2-rds
#14
Michelle L Milstein, Victoria A Kimler, Chiranjib Ghatak, Alexey S Ladokhin, Andrew F X Goldberg
Peripherin-2/rds is required for biogenesis of vertebrate photoreceptor outer segment organelles. Its localization at the high-curvature rim domains of outer segment disk membranes suggests that it may act to shape these structures; however, the molecular function of this protein is not yet resolved. Here, we apply biochemical, biophysical, and imaging techniques to elucidate the role(s) played by the protein's intrinsically disordered C-terminal domain and an incipient amphipathic α-helix contained within it...
May 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28323903/global-potential-distribution-of-drosophila-suzukii-diptera-drosophilidae
#15
Luana A Dos Santos, Mayara F Mendes, Alexandra P Krüger, Monica L Blauth, Marco S Gottschalk, Flávio R M Garcia
Drosophila suzukii (Matsumura) is a species native to Western Asia that is able to pierce intact fruit during egg laying, causing it to be considered a fruit crop pest in many countries. Drosophila suzukii have a rapid expansion worldwide; occurrences were recorded in North America and Europe in 2008, and South America in 2013. Due to this rapid expansion, we modeled the potential distribution of this species using the Maximum Entropy Modeling (MaxEnt) algorithm and the Genetic Algorithm for Ruleset Production (GARP) using 407 sites with known occurrences worldwide and 11 predictor variables...
2017: PloS One
https://www.readbyqxmd.com/read/28290453/suppressive-il-17a-foxp3-and-ex-th17-il-17a-neg-foxp3-treg-cells-are-a-source-of-tumour-associated-treg-cells
#16
Stephanie Downs-Canner, Sara Berkey, Greg M Delgoffe, Robert P Edwards, Tyler Curiel, Kunle Odunsi, David L Bartlett, Nataša Obermajer
Th17 and regulatory T (Treg) cells are integral in maintaining immune homeostasis and Th17-Treg imbalance is associated with inflammatory immunosuppression in cancer. Here we show that Th17 cells are a source of tumour-induced Foxp3(+) cells. In addition to natural (n)Treg and induced (i)Treg cells that develop from naive precursors, suppressive IL-17A(+)Foxp3(+) and ex-Th17 Foxp3(+) cells are converted from IL-17A(+)Foxp3(neg) cells in tumour-bearing mice. Metabolic phenotyping of Foxp3-expressing IL-17A(+), ex-Th17 and iTreg cells demonstrates the dissociation between the metabolic fitness and the suppressive function of Foxp3-expressing Treg cell subsets...
March 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28278197/the-role-of-platelet-and-endothelial-garp-in-thrombosis-and-hemostasis
#17
Elien Vermeersch, Frederik Denorme, Wim Maes, Simon F De Meyer, Karen Vanhoorelbeke, Justin Edwards, Ethan M Shevach, Derya Unutmaz, Hodaka Fujii, Hans Deckmyn, Claudia Tersteeg
BACKGROUND: Glycoprotein-A Repetitions Predominant protein (GARP or LRRC32) is present on among others human platelets and endothelial cells. Evidence for its involvement in thrombus formation was suggested by full knockout of GARP in zebrafish. OBJECTIVES: To evaluate the role of GARP in platelet physiology and in thrombus formation using platelet and endothelial conditional GARP knock out mice. METHODS: Platelet and endothelial specific GARP knockout mice were generated using the Cre-loxP recombination system...
2017: PloS One
https://www.readbyqxmd.com/read/28261204/expression-of-garp-is-increased-in-tumor-infiltrating-regulatory-t-cells-and-is-correlated-to-clinicopathology-of-lung-cancer-patients
#18
Hao Jin, Liping Sun, Lu Tang, Wenwen Yu, Hui Li
Regulatory T cells (Tregs) are immunosuppressive T cells that play an important role in immune homeostasis. Multiple markers have been associated with the characterization, as well as function of Tregs. Recently, glycoprotein A repetitions predominant (GARP), a transmembrane protein containing leucine-rich repeats, has been found to be highly expressed on the surface of activated Tregs. GARP maintains Tregs' regulatory function and homeostasis through the activation and secretion of transforming growth factor β...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28207945/cd4-%C3%A2-cd25-%C3%A2-garp-regulatory-t-cells-display-a-compromised-suppressive-function-in-patients-with-dilated-cardiomyopathy
#19
Yuzhen Wei, Kunwu Yu, Hui Wei, Xin Su, Ruirui Zhu, Huairui Shi, Haitao Sun, Quan Luo, Wenbin Xu, Junhui Xiao, Yucheng Zhong, Qiutang Zeng
Dilated cardiomyopathy (DCM) is a lethal inflammatory heart disease and closely connected with dysfunction of the immune system. Glycoprotein A repetitions predominant (GARP) expressed on activated CD4(+) T cells with suppressive activity has been established. This study aimed to investigate the frequency and function of circulating CD4(+)  CD25(+)  GARP(+) regulatory T (Treg) cells in DCM. Forty-five DCM patients and 46 controls were enrolled in this study. There was a significant increase in peripheral T helper type 1 (Th1) and Th17 number and their related cytokines [interferon-γ (IFN-γ), interleukin (IL-17)], and an obvious decrease in Treg number, transforming growth factor-β1 (TGF-β1 ) levels and the expression of forkhead box P3 (FOXP3) and GARP in patients with DCM compared with controls...
July 2017: Immunology
https://www.readbyqxmd.com/read/28198469/garp2-accelerates-retinal-degeneration-in-rod-cgmp-gated-cation-channel-%C3%AE-subunit-knockout-mice
#20
Marci L DeRamus, Delores A Stacks, Youwen Zhang, Carrie E Huisingh, Gerald McGwin, Steven J Pittler
The Cngb1 locus-encoded β-subunit of rod cGMP-gated cation channel and associated glutamic acid rich proteins (GARPs) are required for phototransduction, disk morphogenesis, and rod structural integrity. To probe individual protein structure/function of the GARPs, we have characterized several transgenic mouse lines selectively restoring GARPs on a Cngb1 knockout (X1(-/-)) mouse background. Optical coherence tomography (OCT), light and transmission electron microscopy (TEM), and electroretinography (ERG) were used to analyze 6 genotypes including WT at three and ten weeks postnatal...
February 15, 2017: Scientific Reports
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