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https://www.readbyqxmd.com/read/28109313/can-an-educational-podcast-improve-the-ability-of-parents-of-primary-school-children-to-assess-the-reliability-of-claims-made-about-the-benefits-and-harms-of-treatments-study-protocol-for-a-randomised-controlled-trial
#1
Daniel Semakula, Allen Nsangi, Matt Oxman, Astrid Austvoll-Dahlgren, Sarah Rosenbaum, Margaret Kaseje, Laetitia Nyirazinyoye, Atle Fretheim, Iain Chalmers, Andrew D Oxman, Nelson K Sewankambo
BACKGROUND: Claims made about the effects of treatments are very common in the media and in the population more generally. The ability of individuals to understand and assess such claims can affect their decisions and health outcomes. Many people in both low- and high-income countries have inadequate aptitude to assess information about the effects of treatments. As part of the Informed Healthcare Choices project, we have prepared a series of podcast episodes to help improve people's ability to assess claims made about treatment effects...
January 21, 2017: Trials
https://www.readbyqxmd.com/read/28108599/basal-vs-non-basal-polarity-different-endomembrane-trafficking-pathways-establish-different-patterns
#2
Nancy Rosenbaum Hofmann
No abstract text is available yet for this article.
January 20, 2017: Plant Cell
https://www.readbyqxmd.com/read/28106418/spatiotemporal-dynamics-and-reliable-computations-in-recurrent-spiking-neural-networks
#3
Ryan Pyle, Robert Rosenbaum
Randomly connected networks of excitatory and inhibitory spiking neurons provide a parsimonious model of neural variability, but are notoriously unreliable for performing computations. We show that this difficulty is overcome by incorporating the well-documented dependence of connection probability on distance. Spatially extended spiking networks exhibit symmetry-breaking bifurcations and generate spatiotemporal patterns that can be trained to perform dynamical computations under a reservoir computing framework...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28100238/chronic-physical-conditions-multimorbidity-and-physical-activity-across-46-low-and-middle-income-countries
#4
Davy Vancampfort, Ai Koyanagi, Philip B Ward, Simon Rosenbaum, Felipe B Schuch, James Mugisha, Justin Richards, Joseph Firth, Brendon Stubbs
BACKGROUND: There are no nationally representative population-based studies investigating the relationship between physical activity, chronic conditions and multimorbidity (i.e., two or more chronic conditions) in low- and middle-income countries (LMICs), and studies on a multi-national level are lacking. This is an important research gap, given the rapid increase in the prevalence of chronic diseases associated with lifestyle changes in these countries. This cross-sectional study aimed to assess the association between chronic conditions, multimorbidity and low physical activity (PA) among community-dwelling adults in 46 LMICs, and explore the mediators of these relationships...
January 18, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28088704/an-examination-of-the-anxiolytic-effects-of-exercise-for-people-with-anxiety-and-stress-related-disorders-a-meta-analysis
#5
REVIEW
Brendon Stubbs, Davy Vancampfort, Simon Rosenbaum, Joseph Firth, Theodore Cosco, Nicola Veronese, Giovanni A Salum, Felipe B Schuch
The literature regarding exercise for people with established anxiety disorders is equivocal. To address this issue, we conducted a systematic review and meta-analysis investigating the benefits of exercise compared to usual treatment or control conditions in people with an anxiety and/or stress-related disorders. Major electronic databases were searched from inception until December/2015 and a random effect meta-analysis conducted. Altogether, six randomized control trials (RCTs) including 262 adults (exercise n=132, 34...
January 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28080012/medicaid-s-future-what-might-aca-repeal-mean
#6
Sara Rosenbaum, Sara Rothenberg, Rachel Gunsalus, Sara Schmucker
Issue: Republicans in Congress are expected to repeal portions of the Affordable Care Act (ACA) using a fast-track process known as budget reconciliation. Goals: This issue brief examines how repeal legislation could affect Medicaid, the nation’s health care safety net, which insured 70 million people in 2016. Findings and Conclusions: Partial-repeal legislation that passed Congress but was vetoed by President Obama in 2016 offers some insight but new legislation could go further. It could repeal the ACA’s Medicaid eligibility expansions for adults and children but also roll back other provisions, such as simplified enrollment and improvements in long-term services and supports for beneficiaries with disabilities...
2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28068135/the-pediatric-patient-centered-medical-home-innovative-models-for-improving-behavioral-health
#7
Joan Rosenbaum Asarnow, David J Kolko, Jeanne Miranda, Anne E Kazak
This article examines the concept of the Patient-Centered Medical Home (PCMH) as it applies to children and adolescents, emphasizing care for behavioral health conditions, the role of psychology and psychological science, and next steps for developing evidence-informed models for the Pediatric-PCMH. The PCMH concept for pediatric populations offers unique opportunities for psychological science to inform and enhance the transformation of the United States health care system and improve health in our nation...
January 2017: American Psychologist
https://www.readbyqxmd.com/read/28067359/antibacterial-properties-of-nanostructured-cu-tio2-surfaces-for-dental-implants
#8
Jonathan Rosenbaum, Davy Louis Versace, Samir Abbad-Andallousi, Remi Pires, Christophe Azevedo, Pierre Cénédese, Pierre Dubot
The influence of copper derived TiO2 surfaces (nCu-nT-TiO2) on the death of nosocomial Staphylococcus aureus (Sa) and Escherichia coli (Ec), was investigated. TiO2 nanotube (nT-TiO2) arrays were fabricated by anodic oxidation of pure titanium sheets in fluorhydric solutions, leading to surface nanostructuration and creation of specific reactive sites. Copper nanocubes with a mean size of 20 nm have been synthesized and deposited on the nT-TiO2 surface by pulsed electrodeposition from a copper sulphate solution...
January 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28033521/physical-activity-and-sedentary-behavior-in-people-with-major-depressive-disorder-a-systematic-review-and-meta-analysis
#9
REVIEW
Felipe Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Philip Ward, Thaís Reichert, Natália Carvalho Bagatini, Roberta Bgeginski, Brendon Stubbs
BACKGROUND: Low levels of physical activity (PA) and sedentary behavior (SB) are independent risk factors for cardiovascular disease and premature mortality in people with major depressive disorder (MDD). AIMS: Investigate levels of PA and SB and their predictors in people with MDD. METHODS: Electronic databases were searched from inception till 04/2016 for articles measuring PA and SB with a self-report questionnaire (SRQ) or objective measure (e...
November 29, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28025809/the-human-orexin-hypocretin-receptor-crystal-structures
#10
Jie Yin, Daniel M Rosenbaum
The human orexin/hypocretin receptors (hOX1R and hOX2R) are G protein-coupled receptors (GPCRs) that mediate the diverse functions of the orexin/hypocretin neuropeptides. Orexins/hypocretins produced by neurons in the lateral hypothalamus stimulate their cognate GPCRs in multiple regions of the central nervous system to control sleep and arousal, circadian rhythms, metabolism, reward pathways, and other behaviors. Dysfunction of orexin/hypocretin signaling is associated with human disease, and the receptors are active targets in a number of therapeutic areas...
December 27, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28025238/racial-disparities-in-medicaid-asthma-hospitalizations
#11
Jeffrey H Silber, Paul R Rosenbaum, Shawna R Calhoun, Joseph G Reiter, Alexander S Hill, James P Guevara, Joseph J Zorc, Orit Even-Shoshan
BACKGROUND AND OBJECTIVES: Black children with asthma comprise one-third of all asthma patients in Medicaid. With increasing Medicaid coverage, it has become especially important to monitor Medicaid for differences in hospital practice and patient outcomes by race. METHODS: A multivariate matched cohort design, studying 11 079 matched pairs of children in Medicaid (black versus white matched pairs from inside the same state) admitted for asthma between January 1, 2009 and November 30, 2010 in 33 states contributing adequate Medicaid Analytic eXtract claims...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/28004392/a-critical-period-of-corticomuscular-and-emg-emg-coherence-detection-in-9-25-week-old-healthy-infants
#12
Anina Ritterband-Rosenbaum, Anna Herskind, Xi Li, Maria Willerslev-Olsen, Mikkel Damgaard Olsen, Simon Francis Farmer, Jens Bo Nielsen
The early postnatal development of functional corticospinal connections in human infants is not fully clarified. We used EEG and EMG to investigate the development of corticomuscular and intramuscular coherence as indicators of functional corticospinal connectivity in healthy infants aged 1-66 weeks. EEG was recorded over leg and hand area of motor cortex. EMG recordings were made from right ankle dorsiflexor and right wrist extensor muscles. Quantification of the amount of corticomuscular coherence in the 20-40 Hz frequency band showed a significantly larger coherence for infants aged 9-25 weeks compared to younger and older infants...
December 22, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/28004357/yttrium-90-radioembolization-for-colorectal-cancer-liver-metastases-a-prospective-cohort-study-on-circulating-angiogenic-factors-and-treatment-response
#13
C E N M Rosenbaum, A F van den Hoven, M N G J A Braat, M Koopman, M G E H Lam, B A Zonnenberg, H M Verkooijen, M A A J van den Bosch
BACKGROUND: Yttrium-90 radioembolization ((90)Y-RE) as a treatment for liver tumours induces radiation damage and hypoxia in liver tissue, which is also a trigger for systemic release of angiogenic factors, potentially stimulating tumour growth. We examined changes in circulating angiogenic factors following (90)Y-RE and investigated the association between response and angiogenic factors. In this prospective study, 42 patients with unresectable, chemorefractory metastatic colorectal cancer (CRCLM) were treated with (90)Y-RE...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27999200/metalloproteinase-meprin-%C3%AE-regulates-migration-and-invasion-of-human-hepatocarcinoma-cells-and-is-a-mediator-of-the-oncoprotein-reptin
#14
Osman Breig, Maïlyn Yates, Véronique Neaud, Gabrielle Couchy, Aude Grigoletto, Carlo Lucchesi, Johannes Prox, Jessica Zucman-Rossi, Christoph Becker-Pauly, Jean Rosenbaum
Hepatocellular carcinoma is associated with a high rate of intra-hepatic invasion that carries a poor prognosis. Meprin alpha (Mep1A) is a secreted metalloproteinase with many substrates relevant to cancer invasion. We found that Mep1A was a target of Reptin, a protein that is oncogenic in HCC. We studied Mep1A regulation by Reptin, its role in HCC, and whether it mediates Reptin oncogenic effects.MepA and Reptin expression was measured in human HCC by qRT-PCR and in cultured cells by PCR, western blot and enzymatic activity measurements...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27998800/patients-in-session-experiences-and-symptom-change-session-to-session-effects-on-a-within-and-between-patient-level
#15
Julian A Rubel, David Rosenbaum, Wolfgang Lutz
OBJECTIVE: Knowledge of patients' in-session experiences that lead to symptom change in psychotherapy is limited. This study aims to investigate the within- and between-patient relationships between three in-session processes in psychotherapy (coping skills, therapeutic relationship quality, and emotional involvement) and symptom change on a session-by-session level. METHOD: Participants (n = 1550) with various disorders, including primarily depression and anxiety, were treated with CBT in a German outpatient clinic...
December 13, 2016: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/27998033/current-physical-activity-monitors-in-hip-and-knee-osteoarthritis-a-review
#16
REVIEW
Maik Sliepen, Mirko Brandes, Dieter Rosenbaum
OBJECTIVE: To provide an up-to-date overview of physical activity monitors that are being/have been used within hip and knee osteoarthritis research. METHODS: A review was conducted to identify activity monitors used in hip and knee osteoarthritis research. In order to identify the relevant literature to-date, the MEDLINE (via Pubmed), EMBASE (via OVID) and SCOPUS databases were searched from January 2000 until January 2016. Per activity monitor, a broad range of specifications was identified by extracting information from the manufacturers' websites, device manuals and literature...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27995718/when-old-is-new-medicaid-s-epsdt-benefit-at-fifty-and-the-future-of-child-health-policy
#17
Sara Rosenbaum
No abstract text is available yet for this article.
December 2016: Milbank Quarterly
https://www.readbyqxmd.com/read/27993881/flow-cytometric-panel-reactive-antibody-results-and-the-ability-to-find-transfusion-compatible-platelets-after-antibody-desensitization-for-allogeneic-bone-marrow-transplant
#18
Eric R Rosenbaum, Soumya Pandey, Terry O Harville, Gina A Drobena, Michele Cottler-Fox
BACKGROUND: Panel reactive antibody (PRA) reduction protocols are used to decrease anti-HLA antibodies with concomitant PRA monitoring as a measure of successful treatment prior to organ and haploidentical blood and marrow transplant (BMT). We hypothesized that the more sensitive flow cytometry (FC) based assays for PRA [FlowPRA(®) and Luminex(®) based Single Antigen Bead (SAB)] would also correlate with the ability to find compatible platelets for allosensitized recipients. METHODS: A female patient with myelodysplastic syndrome and a high HLA class I PRA [>90% PRA and cPRA by complement-dependent cytotoxicity (CDC) assay and Flow PRA] required allogeneic BMT...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27992626/sex-and-racial-ethnic-differences-in-positive-outcomes-in-delinquent-youth-after-detention-a-12-year-longitudinal-study
#19
Karen M Abram, Nicole M Azores-Gococo, Kristin M Emanuel, David A Aaby, Leah J Welty, Jennifer A Hershfield, Melinda S Rosenbaum, Linda A Teplin
Importance: Longitudinal studies of delinquent youth have focused on criminal recidivism, not on psychosocial outcomes in adulthood. This omission is critical because after detention most youth return to the community, where they become the responsibility of pediatric health care professionals. Objective: To investigate 8 positive outcomes among delinquent youth 5 and 12 years after detention, focusing on sex and racial/ethnic differences. Design, Setting, and Participants: In the Northwestern Juvenile Project, a longitudinal US study of long-term outcomes of delinquent youth after detention, participants were interviewed in detention between November 20, 1995, and June 14, 1998, and reinterviewed up to 9 times during the 12-year study period, through May 12, 2011...
December 19, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27978598/the-subgingival-microbiome-systemic-inflammation-and-insulin-resistance-the-oral-infections-glucose-intolerance-and-insulin-resistance-study-origins
#20
Ryan T Demmer, Alexander Breskin, Michael Rosenbaum, Aleksandra Zuk, Charles LeDuc, Rudolph Leibel, Bruce Paster, Moïse Desvarieux, David R Jacobs, Panos N Papapanou
BACKGROUND: Inflammation might link microbial exposures to insulin resistance. We investigated the cross-sectional association between periodontal microbiota, inflammation and insulin resistance. METHODS: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS) enrolled 152 diabetes-free adults (77% female) aged 20-55 years (mean=34±10). 304 subgingival plaque samples were analyzed using the Human Oral Microbe Identification Microarray to measure the relative abundances of 379 taxa...
December 15, 2016: Journal of Clinical Periodontology
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