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https://www.readbyqxmd.com/read/29769808/decision-making-around-gastrostomy-tube-feeding-in-children-with-neurologic-impairment-engaging-effectively-with-families
#1
Sanjay Mahant, Eyal Cohen, Katherine E Nelson, Peter Rosenbaum
Children with neurologic impairment may not be able to feed safely or sufficiently by mouth to maintain an adequate nutritional state. Gastrostomy tube (G-tube) feeding is an important, often essential, intervention in such situations. However, many parents and families struggle with the decision to proceed with G-tube feeding. This practice point reviews common reasons for decisional conflict in parents and explores key aspects of life with G-tube feeding. A framework for shared decision-making and the International Classification of Functioning, Disability and Health (ICF) approach are highlighted...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29769224/right-ventricular-dysfunction-and-long-term-risk-of-sudden-cardiac-death-in-patients-with-and-without-severe-left-ventricular-dysfunction
#2
Niyada Naksuk, Nicholas Tan, Deepak Padmanabhan, Krishna Kancharla, Nayani Makkar, Vidhushei Yogeswaran, Prakriti Gaba, Pranita Kaginele, David C Riley, Alan M Sugrue, Andrew N Rosenbaum, Majd A El-Harasis, Samuel J Asirvatham, Suraj Kapa, Christopher J McLeod
BACKGROUND: Right ventricular systolic dysfunction (RVD) often coexists with various cardiopulmonary diseases. However, the association between RVD and risk of sudden cardiac death (SCD) has not been well studied. This study examined the risk of SCD associated with RVD in patients with heterogeneous underlying cardiac diseases. METHODS: The Mayo Clinic cardiac care unit database included 5463 consecutive patients with complete echocardiographic evaluation to assess right ventricular systolic function and RVD severity...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29765699/feasibility-and-effects-of-a-home-based-intervention-using-activity-trackers-on-achievement-of-individual-goals-quality-of-life-and-motor-performance-in-patients-with-paediatric-cancer
#3
Miriam Götte, Sabine Verena Kesting, Joachim Gerss, Dieter Rosenbaum, Joachim Boos
Objectives: Supervised exercise interventions during inpatient care are feasible. The objective was to evaluate the usability of activity trackers and centralised monitoring to conduct a home-based exercise intervention during cancer treatment. The primary endpoint and confirmatory analysis was achievement of individual goals for daily steps, compared (A) in the intervention group (IG) over time and (B) between the IG and control group (CG). Secondary endpoints included achievement of goals for active minutes and effects on motor performance and health-related quality of life (hrQoL)...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29761610/pathways-and-mechanisms-linking-dietary-components-to-cardiometabolic-disease-thinking-beyond-calories
#4
REVIEW
K L Stanhope, M I Goran, A Bosy-Westphal, J C King, L A Schmidt, J-M Schwarz, E Stice, A C Sylvetsky, P J Turnbaugh, G A Bray, C D Gardner, P J Havel, V Malik, A E Mason, E Ravussin, M Rosenbaum, J A Welsh, C Allister-Price, D M Sigala, M R C Greenwood, A Astrup, R M Krauss
Calories from any food have the potential to increase risk for obesity and cardiometabolic disease because all calories can directly contribute to positive energy balance and fat gain. However, various dietary components or patterns may promote obesity and cardiometabolic disease by additional mechanisms that are not mediated solely by caloric content. Researchers explored this topic at the 2017 CrossFit Foundation Academic Conference 'Diet and Cardiometabolic Health - Beyond Calories', and this paper summarizes the presentations and follow-up discussions...
May 14, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29755001/understanding-why-patients-no-show-observations-of-2-9-million-outpatient-imaging-visits-over-16-years
#5
Joshua I Rosenbaum, Rebecca J Mieloszyk, Christopher S Hall, Daniel S Hippe, Martin L Gunn, Puneet Bhargava
PURPOSE: To understand why patients "no-show" for imaging appointments, and to provide new insights for improving resource utilization. MATERIALS AND METHODS: We conducted a retrospective analysis of nearly 2.9 million outpatient examinations in our radiology information system from 2000 to 2015 at our multihospital academic institution. No-show visits were identified by the "reason code" entry "NOSHOW" in our radiology information system...
May 10, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29753318/successful-pregnancy-in-maple-syrup-urine-disease-a-case-report-and-review-of-the-literature
#6
Sarah Catharina Grünert, Stefanie Rosenbaum-Fabian, Anke Schumann, Karl Otfried Schwab, Nadja Mingirulli, Ute Spiekerkoetter
BACKGROUND: Maple syrup urine disease (MSUD) is an autosomal recessive disorder of branched-chain amino acid metabolism. Patients with MSUD are at risk of life-threatening metabolic decompensations with ketoacidosis and encephalopathy. These episodes are often triggered by physiological stress. Only few cases of pregnancies in MSUD mothers have been reported so far. CASE PRESENTATION: We present the favorable outcome of a pregnancy in a woman with classical MSUD...
May 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29752150/timing-of-cholecystectomy-in-acute-cholecystitis
#7
Arasi Thangavelu, Steven Rosenbaum, Devi Thangavelu
BACKGROUND: Cholecystitis is an inflammation of the gallbladder that most commonly occurs as a result of obstruction of the cystic duct by gallstones. The current standard of treatment for acute cholecystitis is cholecystectomy. OBJECTIVE: Our goal was to discuss the benefits of and compare early laparoscopic cholecystectomy and delayed laparoscopic cholecystectomy in the treatment of acute cholecystitis. MATERIALS AND METHODS: A Medline literature search was performed dating from January 1982 to July 2015...
May 8, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29740822/dr-google-versus-the-health-practitioner-can-we-still-deliver
#8
EDITORIAL
Peter Rosenbaum
No abstract text is available yet for this article.
June 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29738603/a-powerful-approach-to-the-study-of-moderate-effect-modification-in-observational-studies
#9
Kwonsang Lee, Dylan S Small, Paul R Rosenbaum
Effect modification means the magnitude or stability of a treatment effect varies as a function of an observed covariate. Generally, larger and more stable treatment effects are insensitive to larger biases from unmeasured covariates, so a causal conclusion may be considerably firmer if this pattern is noted if it occurs. We propose a new strategy, called the submax-method, that combines exploratory, and confirmatory efforts to determine whether there is stronger evidence of causality-that is, greater insensitivity to unmeasured confounding-in some subgroups of individuals...
May 8, 2018: Biometrics
https://www.readbyqxmd.com/read/29738278/functional-outcomes-following-post-acute-rehabilitation-for-moderate-to-severe-traumatic-brain-injury
#10
Amy M Rosenbaum, Wayne A Gordon, Antigone Joannou, Brady A Berman
OBJECTIVE: The objective of this study was to examine the benefits of long-term inpatient rehabilitation for individuals with moderate-to-severe traumatic brain injuries (TBIs). METHODS: Retrospective database review of 67 individuals with moderate-to-severe TBI admitted to a specialised inpatient TBI program. Outcome measures are as follows: (1) functional independence measure + functional assessment measure (FIM+FAM; admission, discharge, change scores); (2) discharge designation (community vs...
May 8, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29710096/factors-contributing-to-preschoolers-communicative-participation-outcomes-findings-from-a-population-based-longitudinal-cohort-study-in-ontario-canada
#11
Barbara Jane Cunningham, Steven E Hanna, Peter Rosenbaum, Nancy Thomas-Stonell, Bruce Oddson
Purpose: The aim of this study was to identify predictors of communicative participation outcomes for a large cohort of preschoolers with speech and language impairments. Method: A secondary analysis of longitudinal program evaluation data from Ontario, Canada's Preschool Speech and Language Program was done. Data available for 46,872 children 18-67 months of age (M = 41.76 months, SD = 11.92; 68% boys, 32% girls) were previously used to predict children's communicative participation skill development in 5 levels of function...
April 18, 2018: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29691264/visual-acuity-literacy-and-unintentional-misuse-of-nonprescription-medications
#12
Rebecca J Mullen, Laura M Curtis, Rachel O'Conor, Marina Serper, Danielle McCarthy, Stacy C Bailey, Ruth M Parker, Michael S Wolf
PURPOSE: Results of a study of associations between visual acuity and the risk of misuse of nonprescription acetaminophen products in a sample of community-dwelling adults are reported. METHODS: In a study involving English-speaking adults at 4 primary care clinics, the potential for misuse of nonprescription acetaminophen products was measured via a functional assessment of product self-dosing and by testing patients' understanding of the risks of concomitant use (i...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29690792/physical-activity-and-incident-depression-a-meta-analysis-of-prospective-cohort-studies
#13
Felipe B Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Phillip B Ward, Edson S Silva, Mats Hallgren, Antonio Ponce De Leon, Andrea L Dunn, Andrea C Deslandes, Marcelo P Fleck, Andre F Carvalho, Brendon Stubbs
OBJECTIVE: The authors examined the prospective relationship between physical activity and incident depression and explored potential moderators. METHOD: Prospective cohort studies evaluating incident depression were searched from database inception through Oct. 18, 2017, on PubMed, PsycINFO, Embase, and SPORTDiscus. Demographic and clinical data, data on physical activity and depression assessments, and odds ratios, relative risks, and hazard ratios with 95% confidence intervals were extracted...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29687233/starting-or-finishing-sooner-sequencing-preferences-in-object-transfer-tasks
#14
Lisa R Fournier, Alexandra M Stubblefield, Brian P Dyre, David A Rosenbaum
When tasks are performed, other tasks are postponed, at least implicitly. Little is known about how task sequencing is determined. We examined task sequencing in object transfer tasks for which either task could easily or logically come before the other. The task was to transfer ping pong balls from two buckets into a bowl. To perform the task, participants walked down a corridor, picked up one of two buckets (their choice), carried it to the end of the corridor, transferred the balls from the bucket into a bowl, carried the bucket back to the start position, and then did the same with the other remaining bucket...
April 23, 2018: Psychological Research
https://www.readbyqxmd.com/read/29684174/grip-strength-is-associated-with-cognitive-performance-in-schizophrenia-and-the-general-population-a-uk-biobank-study-of-476559-participants
#15
Joseph Firth, Brendon Stubbs, Davy Vancampfort, Josh A Firth, Matthew Large, Simon Rosenbaum, Mats Hallgren, Philip B Ward, Jerome Sarris, Alison R Yung
Background: Handgrip strength may provide an easily-administered marker of cognitive functional status. However, further population-scale research examining relationships between grip strength and cognitive performance across multiple domains is needed. Additionally, relationships between grip strength and cognitive functioning in people with schizophrenia, who frequently experience cognitive deficits, has yet to be explored. Methods: Baseline data from the UK Biobank (2007-2010) was analyzed; including 475397 individuals from the general population, and 1162 individuals with schizophrenia...
April 19, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29680968/an-increased-waist-to-hip-ratio-is-a-key-determinant-of-atherosclerotic-burden-in-overweight-subjects
#16
Roberto Scicali, David Rosenbaum, Antonino Di Pino, Philippe Giral, Philippe Cluzel, Alban Redheuil, Salvatore Piro, Agata Maria Rabuazzo, Francesco Purrello, Eric Bruckert, Antonio Gallo
AIMS: The association of overweight status and cardiovascular disease is not clear. In this study we aimed to investigate coronary atherosclerotic disease, evaluated as coronary artery calcium score (CACs), in overweight patients with or without abdominal obesity as defined by waist-to-hip ratio (WHR). METHODS: We enrolled 276 patients aged between 40 and 70 years, with a body mass index of 25-29.9 kg/m2 and at least one cardiovascular risk factor. Exclusion criteria were history of diabetes, cardiovascular or renal disease...
April 21, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29677073/outcomes-after-cardiac-transplant-for-wild-type-transthyretin-amyloidosis
#17
Andrew N Rosenbaum, Omar F Abou Ezzeddine, Martha Grogan, Angela Dispenzieri, Sudhir Kushwaha, Alfredo Clavell, Richard C Daly, Brooks S Edwards
BACKGROUND: The true prevalence of heart failure (HF) due to wild type transthyretin amyloidosis (ATTRwt) is likely underestimated. There is a paucity of data with regard to the management of ATTRwt-related advanced HF and the natural history of extracardiac ATTRwt. METHODS: We conducted a retrospective cohort study of patients undergoing cardiac transplant (HTx) for ATTRwt at a single institution. Comprehensive clinical data, including baseline hemodynamic and echocardiographic characteristics, and posttransplant outcomes were obtained...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#18
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29667220/the-war-on-poverty-2018-style
#19
Sara Rosenbaum
No abstract text is available yet for this article.
April 17, 2018: Milbank Quarterly
https://www.readbyqxmd.com/read/29656895/tracking-cancer-evolution-reveals-constrained-routes-to-metastases-tracerx-renal
#20
Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Tim Chambers, Jose I Lopez, David Nicol, Tim O'Brien, James Larkin, Stuart Horswell, Mark Stares, Lewis Au, Mariam Jamal-Hanjani, Ben Challacombe, Ashish Chandra, Steve Hazell, Claudia Eichler-Jonsson, Aspasia Soultati, Simon Chowdhury, Sarah Rudman, Joanna Lynch, Archana Fernando, Gordon Stamp, Emma Nye, Faiz Jabbar, Lavinia Spain, Sharanpreet Lall, Rosa Guarch, Mary Falzon, Ian Proctor, Lisa Pickering, Martin Gore, Thomas B K Watkins, Sophia Ward, Aengus Stewart, Renzo DiNatale, Maria F Becerra, Ed Reznik, James J Hsieh, Todd A Richmond, George F Mayhew, Samantha M Hill, Catherine D McNally, Carol Jones, Heidi Rosenbaum, Stacey Stanislaw, Daniel L Burgess, Nelson R Alexander, Charles Swanton
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure...
April 9, 2018: Cell
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