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https://www.readbyqxmd.com/read/28445080/bridging-the-data-sharing-divide-seeing-the-devil-in-the-details-not-the-other-camp
#1
Lisa Rosenbaum
No abstract text is available yet for this article.
April 26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28443675/the-effect-of-trigger-finger-injection-site-on-injection-related-pain
#2
Yoseph A Rosenbaum, Nikki Benvenuti, Jingzhen Yang, Michael E Ruff, Hisham M Awan, Julie Balch Samora
BACKGROUND: Stenosing tenosynovitis, or trigger digit, is a common condition for which patients often seek relief. Corticosteroid injections have been shown to provide relief in many cases, and several different approaches for delivering the injection have been described in the literature. We compared patients' perception of pain following each of 3 accepted injection methods, namely, palmar proximal, palmar distal, and webspace approaches. METHODS: We prospectively followed 38 patients with 39 symptomatic digits in this trial, with varying severities of trigger finger as graded by the Patel and Moradia classification...
April 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28437038/impact-of-preoperative-risk-on-metastatic-progression-and-cancer-specific-death-in-patients-with-adverse-pathology-at-radical-prostatectomy
#3
Katharina Boehm, Sami-Ramzi Leyh-Bannurah, Clemens Rosenbaum, Laurenz S Brandi, Lars Budäus, Markus Graefen, Hartwig Huland, Axel Haferkamp, Derya Tilki
OBJECTIVE: To evaluate the impact of preoperative risk category on metastatic disease (MetD) and prostate cancer mortality (CSM) in prostate cancer (PCa) patients with adverse pathology at radical prostatectomy (RP). PATIENTS AND METHODS: The records of 6943 patients who underwent radical prostatectomy (RP) in a European tertiary-center were analysed. Biochemical recurrence (BCR), MetD and CSM were assessed for patients with adverse pathology at RP and stratified according to preoperative low- vs...
April 24, 2017: BJU International
https://www.readbyqxmd.com/read/28433444/risk-of-ocular-hypertension-in-adults-with-noninfectious-uveitis
#4
Ebenezer Daniel, Maxwell Pistilli, Srishti Kothari, Naira Khachatryan, R Oktay Kaçmaz, Sapna S Gangaputra, H Nida Sen, Eric B Suhler, Jennifer E Thorne, C Stephen Foster, Douglas A Jabs, Robert B Nussenblatt, James T Rosenbaum, Grace A Levy-Clarke, Nirali P Bhatt, John H Kempen
PURPOSE: To describe the risk and risk factors for ocular hypertension (OHT) in adults with noninfectious uveitis. DESIGN: Retrospective, multicenter, cohort study. PARTICIPANTS: Patients aged ≥18 years with noninfectious uveitis seen between 1979 and 2007 at 5 tertiary uveitis clinics. METHODS: Demographic, ocular, and treatment data were extracted from medical records of uveitis cases. MAIN OUTCOME MEASURES: Prevalent and incident OHT with intraocular pressures (IOPs) of ≥21 mmHg, ≥30 mmHg, and increase of ≥10 mmHg from documented IOP recordings (or use of treatment for OHT)...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28432691/tenapanor-administration-and-the-activity-of-the-h-coupled-transporter-pept1-in-healthy-volunteers
#5
Susanne Johansson, David P Rosenbaum, Johan Palm, Bergur Stefansson, Mikael Knutsson, Eleanor A Lisbon, Constanze Hilgendorf
AIM: Tenapanor (RDX5791/AZD1722), an inhibitor of gastrointestinal Na(+) /H(+) exchanger NHE3, is being evaluated for the treatment of patients with constipation-predominant irritable bowel syndrome and the treatment of hyperphosphataemia in patients with chronic kidney disease on dialysis. By reducing intestinal H(+) secretion, inhibition of NHE3 by tenapanor could indirectly affect H(+) -coupled transporter activity, leading to drug-drug interactions. We investigated the effect of tenapanor on the activity of the H(+) -coupled peptide transporter PepT1 via assessment of the pharmacokinetics of cefadroxil - a compound transported by PepT1 - in healthy volunteers...
April 22, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28427889/lost-in-translation-cultural-divides-in-communication-skills-teaching-identified-in-the-icch-2016-student-symposium
#6
Heather K Schopper, Nasteha A Mohamed, Max Seegel, Kseniya Gorina, Jonathan Silverman, Marcy Rosenbaum
OBJECTIVE: To provide a platform for learners' voices at an international conference on communication in healthcare. METHODS: A group of medical students were invited to explore their experiences with communication skills learning at a symposium at the 2016 International Conference on Communication in Healthcare in Heidelberg, DE. RESULTS: Students from the US, Denmark, Germany, and Russia discussed their experiences with communication skills curriculum at their institutions...
April 12, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28397326/diagnosis-and-management-of-neuropathies-associated-with-plasma-cell-dyscrasias
#7
REVIEW
Evan Rosenbaum, Douglas Marks, Shahzad Raza
Neuropathies associated with plasma cell dyscrasias are a major cause of morbidity for patients managed by medical oncologists. Because of similarities in clinical presentation and on nerve conduction studies, identifying the underlying disease leading to a paraproteinemic neuropathy can often be difficult. In addition, the degree of neurologic deficit does not strictly correlate with the extent of abnormalities on common clinical laboratory testing. Fortunately, with increasing understanding into the biologic mechanisms of underlying hematologic diseases, additional biomarkers have recently been developed, thus improving our diagnostic capacity...
April 10, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28396057/general-principles-to-consider-when-designing-a-clinical-communication-assessment-program
#8
Claudia Kiessling, Zoi Tsimtsiou, Geurt Essers, Marc van Nuland, Tor Anvik, Maria M Bujnowska-Fedak, Richard Hovey, Ragnar Joakimsen, Noëlle Junod Perron, Marcy Rosenbaum, Jonathan Silverman
OBJECTIVES: Assessment of clinical communication helps teachers in healthcare education determine whether their learners have acquired sufficient skills to meet the demands of clinical practice. The aim of this paper is to give input to educators when planning how to incorporate assessment into clinical communication teaching by building on the authors' experience and current literature. METHODS: A summary of the relevant literature within healthcare education is discussed, focusing on what and where to assess, how to implement assessment and how to choose appropriate methodology...
March 27, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28376061/new-developments-in-uveitis-associated-with-hla-b27
#9
James T Rosenbaum
PURPOSE OF REVIEW: Uveitis is the most common, clinically apparent, extra-articular manifestation of axial spondyloarthritis. This review summarizes recent publications related to this form of uveitis. RECENT FINDINGS: Studies published since the start of 2015 address the worldwide prevalence of human leukocyte antigen (HLA) B27-associated uveitis, the prevalence of axial spondyloarthritis among patients with B27-associated acute anterior uveitis (AAU), the genetics of AAU and some of the clinical implications of AAU...
April 3, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28372805/corrigendum-to-patients-in-session-experiences-and-symptom-change-session-to-session-effects-on-a-within-and-between-patient-level-behav-res-ther-90-2017-58-66
#10
Julian A Rubel, David Rosenbaum, Wolfgang Lutz
No abstract text is available yet for this article.
June 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28355116/quality-of-survivorship-in-a-rare-disease-clinicofunctional-outcome-and-physical-activity-in-an-observational-cohort-study-of-618-long-term-survivors-of-ewing-sarcoma
#11
Andreas Ranft, Corinna Seidel, Christiane Hoffmann, Michael Paulussen, Ann-Christin Warby, Henk van den Berg, Ruth Ladenstein, Claudia Rossig, Uta Dirksen, Dieter Rosenbaum, Herbert Juergens
Purpose Significantly improved survival rates in patients with Ewing sarcoma have raised interest in accessing the quality of long-term survivorship. In this study, subjective and objective measurement tools, preclassified as physical or mental scores, were used to assess clinicofunctional outcome and physical activity after intensive bone tumor treatment. Methods Long-term outcome of 618 survivors from consecutive Ewing sarcoma trials was assessed by the Toronto Extremity Salvage Score, Short-Form Health Survey (SF-36), Brief Symptom Inventory (BSI), and Rosenberg Self-Esteem Scale questionnaires and by the accelerometric StepWatch 3 Activity Monitor...
March 29, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28353189/reflections-on-ethics-and-humanity-in-pediatric-neurology-the-value-of-recognizing-ethical-issues-in-common-clinical-practice
#12
REVIEW
Gabriel M Ronen, Peter L Rosenbaum
Our goals in this reflection are to (i) identify the ethical dimensions inherent in any clinical encounter and (ii) bring to the forefront of our pediatric neurology practice the myriad of opportunities to explore and learn from these ethical questions. We highlight specifically Beauchamp and Childress's principles of biomedical ethics. We use the terms ethics in common clinical practice and an ethical lens to remind people of the ubiquity of ethical situations and the usefulness of using existing ethical principles to analyze and resolve difficult situations in clinical practice...
May 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28351118/how-will-repealing-the-aca-affect-medicaid-impact-on-health-care-coverage-delivery-and-payment
#13
Sara Rosenbaum, Sara Rothenberg, Sara Schmucker, Rachel Gunsalus, J. Zoë Beckerman
ISSUE: The Affordable Care Act enhanced Medicaid's role as a health care purchaser by expanding eligibility and broadening the range of tools and strategies available to states. All states have embraced delivery and payment reform as basic elements of their programs. GOAL: To examine the effects of reducing the size and scope of Medicaid under legislation to repeal the ACA. FINDINGS AND CONCLUSIONS: Were the ACA's Medicaid expansion to be eliminated and were federal Medicaid funding to experience major reductions through block grants or per capita caps, the effects on system transformation would be significant...
March 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28349093/regulation-of-thermotrps-by-lipids
#14
REVIEW
Sara L Morales-Lázaro, Luis Lemus, Tamara Rosenbaum
The family of Transient Receptor Potential (TRP) ion channels is constituted by 7 subfamilies among which are those that respond to temperature, the thermoTRPs. These channels are versatile molecules of a polymodal nature that have been shown to be modulated in various fashions by molecules of a lipidic nature. Some of these molecules interact directly with the channels on specific regions of their structures and some of these promote changes in membrane fluidity or modify their gating properties in response to their agonists...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28342834/aces-and-child-health-policy-the-enduring-case-for-epsdt
#15
Sara Rosenbaum
No abstract text is available yet for this article.
March 22, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28339149/effect-of-food-intake-on-the-pharmacodynamics-of-tenapanor-a-phase-1-study
#16
Susanne A Johansson, Mikael Knutsson, Maria Leonsson-Zachrisson, David P Rosenbaum
Tenapanor (RDX5791/AZD1722) is a minimally systemic small-molecule inhibitor of the sodium/hydrogen exchanger NHE3. Tenapanor acts in the gut to reduce absorption of sodium and phosphate. This phase 1 open-label, 3-way crossover study (NCT02226783) evaluated the effect of food on the pharmacodynamics of tenapanor. Eighteen volunteers completed a randomized sequence of three 4-day treatments with tenapanor hydrochloride 15 mg twice daily: before food, after food, and while fasting. Participants received a diet standardized for sodium content...
March 24, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28333968/a-genome-wide-association-study-of-thyroid-stimulating-hormone-and-free-thyroxine-in-danish-children-and-adolescents
#17
Tenna Ruest Haarmark Nielsen, Emil Vincent Rosenbaum Appel, Mathilde Svendstrup, Johanne Dam Ohrt, Maria Dahl, Cilius Esmann Fonvig, Mette Hollensted, Christian Theil Have, Haja N Kadarmideen, Oluf Pedersen, Torben Hansen, Jens-Christian Holm, Niels Grarup
BACKGROUND: Hypothyroidism is associated with obesity, and thyroid hormones are involved in the regulation of body composition, including fat mass. Genome-wide association studies (GWAS) in adults have identified 19 and 6 loci associated with plasma concentrations of thyroid stimulating hormone (TSH) and free thyroxine (fT4), respectively. OBJECTIVE: This study aimed to identify and characterize genetic variants associated with circulating TSH and fT4 in Danish children and adolescents and to examine whether these variants associate with obesity...
2017: PloS One
https://www.readbyqxmd.com/read/28329509/the-department-of-defense-pioneers-of-early-teledermatology
#18
Brooke E Rosenbaum, Campion H Campion, Jeffrey M Cohen, Jo-Ann Latkowski
The United States (US) Department of Defense(DoD) has been a leader in using telecommunicationstechnology to provide remote medical care. The DoDhas been using telemedicine for more than twentyyears to provide medical services to military personneldeployed throughout the world, and has largelyinfluenced the development of teledermatology. Theexperiences of early military teledermatology serviceshave yielded valuable lessons that have been essentialto the creation of successful civilian programs.
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329282/possible-transfusion-transmitted-babesia-divergens-like-mo-1-in-an-arkansas-patient
#19
Mary J Burgess, Eric R Rosenbaum, Bobbi S Pritt, Dirk T Haselow, Katie M Ferren, Bashar N Alzghoul, Juan Carlos Rico, Lynne M Sloan, Poornima Ramanan, Raghunandan Purushothaman, Robert W Bradsher
A patient with asplenia and multiple red blood cell transfusions acquired babesiosis infection with Babesia divergens-like/MO-1 and not Babesia microti, the common United States species. He had no known tick exposure. This is believed to be the first transfusion-transmitted case and the fifth documented case of Babesia divergens-like/MO-1.
March 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28323712/trends-in-inpatient-vertebroplasty-and-kyphoplasty-volume-in-the-united-states-2005-2011-assessing-the-impact-of-randomized-controlled-trials
#20
Benjamin P Rosenbaum, Varun R Kshettry, Michael L Kelly, Thomas E Mroz, Robert J Weil
STUDY DESIGN: Retrospective analysis of the Nationwide Inpatient Sample, 2005-2011. OBJECTIVE: To identify trends in procedural volume and rates in the time period surrounding publication of randomized controlled trials (RCTs) that examined the utility of vertebroplasty and kyphoplasty. SUMMARY OF BACKGROUND DATA: Vertebroplasty and kyphoplasty are frequently performed for vertebral compression fractures. Several RCTs have been published with conflicting outcomes regarding pain and quality of life compared with nonsurgical management and sham procedures...
April 2017: Clinical Spine Surgery
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