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https://www.readbyqxmd.com/read/28329509/the-department-of-defense-pioneers-of-early-teledermatology
#1
Brooke E Rosenbaum, Campion H Campion, Jeffrey M Cohen, Jo-Ann Latkowski
The United States (US) Department of Defense(DoD) has been a leader in using telecommunicationstechnology to provide remote medical care. The DoDhas been using telemedicine for more than twentyyears to provide medical services to military personneldeployed throughout the world, and has largelyinfluenced the development of teledermatology. Theexperiences of early military teledermatology serviceshave yielded valuable lessons that have been essentialto the creation of successful civilian programs.
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329282/possible-transfusion-transmitted-babesia-divergens-like-mo-1-in-an-arkansas-patient
#2
Mary J Burgess, Eric R Rosenbaum, Bobbi S Pritt, Dirk T Haselow, Katie M Ferren, Bashar N Alzghoul, Juan Carlos Rico, Lynne M Sloan, Poornima Ramanan, Raghunandan Purushothaman, Robert W Bradsher
A patient with asplenia and multiple red blood cell transfusions acquired babesiosis infection with Babesia divergens-like/MO-1 and not Babesia microti, the common United States species. He had no known tick exposure. This is believed to be the first transfusion-transmitted case and the fifth documented case of Babesia divergens-like/MO-1.
March 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28323712/trends-in-inpatient-vertebroplasty-and-kyphoplasty-volume-in-the-united-states-2005-2011-assessing-the-impact-of-randomized-controlled-trials
#3
Benjamin P Rosenbaum, Varun R Kshettry, Michael L Kelly, Thomas E Mroz, Robert J Weil
STUDY DESIGN: Retrospective analysis of the Nationwide Inpatient Sample, 2005-2011. OBJECTIVE: To identify trends in procedural volume and rates in the time period surrounding publication of randomized controlled trials (RCTs) that examined the utility of vertebroplasty and kyphoplasty. SUMMARY OF BACKGROUND DATA: Vertebroplasty and kyphoplasty are frequently performed for vertebral compression fractures. Several RCTs have been published with conflicting outcomes regarding pain and quality of life compared with nonsurgical management and sham procedures...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28320785/a-kinase-and-proteasome-mediated-link-between-lipid-biosynthesis-and-energy-homeostasis
#4
Nancy Rosenbaum Hofmann
No abstract text is available yet for this article.
March 20, 2017: Plant Cell
https://www.readbyqxmd.com/read/28320767/comparing-outcomes-between-antibody-induction-therapies-in-kidney-transplantation
#5
Neel Koyawala, Jeffrey H Silber, Paul R Rosenbaum, Wei Wang, Alexander S Hill, Joseph G Reiter, Bijan A Niknam, Orit Even-Shoshan, Roy D Bloom, Deirdre Sawinski, Susanna Nazarian, Jennifer Trofe-Clark, Mary Ann Lim, Jesse D Schold, Peter P Reese
Kidney transplant recipients often receive antibody induction. Previous studies of induction therapy were often limited by short follow-up and/or absence of information about complications. After linking Organ Procurement and Transplantation Network data with Medicare claims, we compared outcomes between three induction therapies for kidney recipients. Using novel matching techniques developed on the basis of 15 clinical and demographic characteristics, we generated 1:1 pairs of alemtuzumab-rabbit antithymocyte globulin (rATG) (5330 pairs) and basiliximab-rATG (9378 pairs) recipients...
March 20, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28320348/methods-for-conceptualising-visual-ability-as-a-measurable-construct-in-children-with-cerebral-palsy
#6
Belinda Deramore Denver, Margareta Adolfsson, Elspeth Froude, Peter Rosenbaum, Christine Imms
BACKGROUND: Vision influences functioning and disability of children with cerebral palsy, so there is a growing need for psychometrically robust tools to advance assessment of children's vision abilities in clinical practice and research. Vision is a complex construct, and in the absence of clarity about this construct it is challenging to know whether valid, reliable measures exist. This study reports a method for conceptualising 'visual ability' as a measurable construct. METHODS: Using the items from 19 assessment tools previously identified in a systematic review, this study used a two-phase process: first, deductive content analysis linked items to the International Classification of Functioning, Disability and Health - Child and Youth version (ICF-CY), and second, vision-specific 'Activity'-level items were explored using inductive thematic analysis...
March 21, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28301096/effects-of-tenapanor-on-cytochrome-p450-mediated-drug-drug-interactions
#7
Susanne Johansson, David P Rosenbaum, Marie Ahlqvist, Helen Rollison, Mikael Knutsson, Bergur Stefansson, Marie Elebring
Tenapanor (RDX5791, AZD1722) is an inhibitor of sodium/hydrogen exchanger isoform 3 in development for the treatment of constipation-predominant irritable bowel syndrome and the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis. We aimed to investigate whether tenapanor inhibits or induces cytochrome P450s (CYPs). In vitro experiments assessing the potential of tenapanor to affect various CYPs indicated that it could inhibit CYP3A4/5 (IC50 0.4-0.7 μM). An open-label, phase 1 clinical study (NCT02140268) evaluated the pharmacokinetics of the CYP3A4 substrate midazolam when administered with and without tenapanor...
March 16, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28287016/acute-hand-injuries-in-athletes
#8
Yoseph A Rosenbaum, Hisham M Awan
Hand and wrist injuries in athletes are common, representing between 3% and 25% of all sports injuries. As many as a quarter of all sports injuries involve the hand or wrist. We review the recent literature regarding acute hand injuries in athletes based on the structures involved - bone, muscle/tendon, ligament, and neurovascular - including diagnosis and pathophysiology of these injuries, focusing on athlete-specific facets of treatment, and when available, opinions on return to play.
March 11, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28283067/transporters-revealed
#9
Jyh-Yeuan Lee, Daniel M Rosenbaum
The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of this ABC transporter subfamily.
March 9, 2017: Cell
https://www.readbyqxmd.com/read/28274788/management-goals-for-type-1-gaucher-disease-an-expert-consensus-document-from-the-european-working-group-on-gaucher-disease
#10
M Biegstraaten, T M Cox, N Belmatoug, M G Berger, T Collin-Histed, S Vom Dahl, M Di Rocco, C Fraga, F Giona, P Giraldo, M Hasanhodzic, D A Hughes, P O Iversen, A I Kiewiet, E Lukina, M Machaczka, T Marinakis, E Mengel, G M Pastores, U Plöckinger, H Rosenbaum, C Serratrice, A Symeonidis, J Szer, J Timmerman, A Tylki-Szymańska, M Weisz Hubshman, D I Zafeiriou, A Zimran, C E M Hollak
Gaucher Disease type 1 (GD1) is a lysosomal disorder that affects many systems. Therapy improves the principal manifestations of the condition and, as a consequence, many patients show a modified phenotype which reflects manifestations of their disease that are refractory to treatment. More generally, it is increasingly recognised that information as to how a patient feels and functions [obtained by patient- reported outcome measurements (PROMs)] is critical to any comprehensive evaluation of treatment. A new set of management goals for GD1 in which both trends are reflected is needed...
October 24, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28266143/the-influence-of-donor-factors-on-corneal-organ-culture-contamination
#11
Anja K Gruenert, Katja Rosenbaum, Gerd Geerling, Thomas A Fuchsluger
PURPOSE: To evaluate the contamination rate and the corresponding spectrum of microbes and to identify donor risk factors for corneal organ culture contaminations. METHODS: A total of 3306 organ-cultured donor corneas were included in the study. We performed a retrospective database analysis to evaluate donor factors such as gender, age, death-to-explantation interval (DEI), procurement site and cause of death and to determine their influence on donor cornea contaminations...
March 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28266066/contraception-as-a-health-insurance-right-what-comes-next
#12
Sara Rosenbaum
No abstract text is available yet for this article.
March 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/28262083/exercise-works-for-depression-bridging-the-implementation-gap-and-making-exercise-a-core-component-of-treatment
#13
Felipe Barreto Schuch, Ioannis Dimitrios Morres, Panteleimon Ekkekakis, Simon Rosenbaum, Brendon Stubbs
No abstract text is available yet for this article.
March 6, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28261580/a-blueprint-to-evaluate-one-health
#14
Simon R Rüegg, Barry J McMahon, Barbara Häsler, Roberto Esposito, Liza Rosenbaum Nielsen, Chinwe Ifejika Speranza, Timothy Ehlinger, Marisa Peyre, Maurizio Aragrande, Jakob Zinsstag, Philip Davies, Andrei Daniel Mihalca, Sandra C Buttigieg, Jonathan Rushton, Luís P Carmo, Daniele De Meneghi, Massimo Canali, Maria E Filippitzi, Flavie Luce Goutard, Vlatko Ilieski, Dragan Milićević, Helen O'Shea, Miroslav Radeski, Richard Kock, Anthony Staines, Ann Lindberg
One Health (OH) positions health professionals as agents for change and provides a platform to manage determinants of health that are often not comprehensively captured in medicine or public health alone. However, due to the organization of societies and disciplines, and the sectoral allocation of resources, the development of transdisciplinary approaches requires effort and perseverance. Therefore, there is a need to provide evidence on the added value of OH for governments, researchers, funding bodies, and stakeholders...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28258886/cross-calibrated-dual-energy-x-ray-absorptiometry-scanners-demonstrate-systematic-bias-in-pediatric-and-young-adult-females
#15
Jodi N Dowthwaite, Kristen A Dunsmore, Dongliang Wang, Paula F Rosenbaum, Tamara A Scerpella
Consistency of dual-energy X-ray absorptiometry (DXA) scan results is critical for data integrity. For pediatric subjects, the extent to which cross-calibration of DXA scanners alleviates model-to-model scanner differences is unclear. In the current study, DXA bone outcomes were compared for same-day measurements performed using different scanners, cross-calibrated to alleviate discrepancies (Hologic; Discovery A [DISCO] and QDR 4500W [QDR]). Interscanner differences were evaluated in approximately 130 females aged 8-24 yr...
February 28, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28257167/cytologic-characteristics-of-circulating-epithelioid-cells-in-pancreatic-disease
#16
Matthew W Rosenbaum, Christy E Cauley, Birte Kulemann, Andrew S Liss, Carlos Fernandez-Del Castillo, Andrew L Warshaw, Keith D Lillemoe, Sarah P Thayer, Martha B Pitman
BACKGROUND: Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. In the current study, the authors analyzed the cytomorphologic characteristics of CECs isolated by size in a cohort of patients with benign and malignant pancreatic diseases to determine whether cytomorphological features could predict CEC origin...
March 3, 2017: Cancer
https://www.readbyqxmd.com/read/28248691/prospective-evaluation-of-postural-control-and-gait-in-pediatric-patients-with-cancer-after-a-4-week-inpatient-rehabilitation-program
#17
Carsten Müller, Dieter Rosenbaum, Konstantin A Krauth
OBJECTIVE: The aim of the study was to investigate the effects of a 4-wk inpatient rehabilitation program on postural control and gait in pediatric patients with cancer. DESIGN: Eighty-eight patients with brain tumors (n = 59) and bone/soft tissue sarcomas (n = 29) were evaluated. Postural control was assessed examining the velocity of the center of pressure and single-leg stance time on a pressure distribution platform. Walk ratio, a measure of neuromotor control, was used to evaluate intervention effects on gait...
February 28, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28248549/resisting-the-suppression-of-science
#18
Lisa Rosenbaum
All doctors encounter patients who express preferences for non–evidence-based therapies — organic food for coronary disease or detox cleanses for cancer, for example. Personally, I’ve never come up with an effective response. I offer facts, and then, sensing that I’m getting nowhere, I offer more..
March 1, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28244495/tenapanor-treatment-of-patients-with-constipation-predominant-irritable-bowel-syndrome-a-phase-2-randomized-placebo-controlled-efficacy-and-safety-trial
#19
William D Chey, Anthony J Lembo, David P Rosenbaum
OBJECTIVES: Tenapanor is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. This study assessed the efficacy and safety of tenapanor in patients with constipation-predominant irritable bowel syndrome (IBS-C). METHODS: In this phase 2, double-blind study, patients with IBS-C (Rome III criteria) were randomized (1:1:1:1) to receive tenapanor 5 mg, 20 mg, or 50 mg b.i.d., or placebo b.i.d. for 12 weeks. The primary end point was the complete spontaneous bowel movement (CSBM) responder rate, defined as the proportion of patients reporting an increase from baseline of ≥1 CSBM/week for ≥6/12 treatment weeks...
February 28, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28244493/imaging-response-during-therapy-with-radium-223-for-castration-resistant-prostate-cancer-with-bone-metastases-analysis-of-an-international-multicenter-database
#20
D Keizman, M O Fosboel, H Reichegger, A Peer, E Rosenbaum, M-C Desax, V Neiman, P M Petersen, J Mueller, R Cathomas, M Gottfried, H Dresler, D Sarid, W Mermershtain, K Rouvinov, J Mortensen, S Gillessen, G Daugaard, A Omlin
BACKGROUND: The imaging response to radium-223 therapy is at present poorly described. We aimed to describe the imaging response to radium-223 treatment. METHODS: We retrospectively evaluated the computed tomography (CT) and bone scintigraphy response of metastatic castration-resistant prostate cancer (CRPC) patients treated with radium-223, in eight centers in three countries. RESULTS: A total of 130 patients were included, the majority (n=84, 65%) received radium-223 post docetaxel...
February 28, 2017: Prostate Cancer and Prostatic Diseases
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