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https://www.readbyqxmd.com/read/28938167/a-method-for-measuring-manual-position-control
#1
Cory Adam Potts, Alexander A Brown, Stanislaw Solnik, David A Rosenbaum
There is no generally accepted method for measuring manual position control. We developed a method for doing so. We asked university students to hold a handle that had one rotational degree of freedom. The angular position of the handle depended on the degree of pronation-supination of the forearm. The subjects' task was to hold the handle as steadily as possible to keep a needle positioned in a pie-shaped target zone on a computer screen. If the needle remained in the zone for 0.5s, the gain of the feedback loop increased; otherwise the gain decreased or remained at the starting value of 1...
September 19, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28929700/extending-the-children%C3%A2-s-health-insurance-program-high-stakes-for-families-and-states
#2
Sara Rosenbaum, Rachel Gunsalus, Sara Rothenberg, Sara Schmucker
Issue: Congress must decide whether to extend federal funding authority for the Children’s Health Insurance Program (CHIP), which ends September 30, 2017. CHIP operates much like Medicaid, providing federal matching payments for state program expenses, although CHIP’s funding rate is higher than the federal rate paid for traditional Medicaid and was further enhanced under the Affordable Care Act. States can use their CHIP funds to expand Medicaid, operate separate CHIP programs, or combine the two approaches...
September 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28929299/the-t-plasty-as-therapy-for-recurrent-bladder-neck-stenosis-success-rate-functional-outcome-and-patient-satisfaction
#3
Clemens M Rosenbaum, Roland Dahlem, Valentin Maurer, Luis A Kluth, Malte W Vetterlein, Margit Fisch, Victor Schuettfort, C Philip Reiss
PURPOSE: To determine success rate (SR), functional outcome, and patient satisfaction of a modified YV-plasty for reconstruction of the bladder neck in case of recurrent bladder neck stenosis (BNS) after transurethral surgery of the prostate: the T-plasty. PATIENTS AND METHODS: We identified all patients who underwent T-plasty at our center between December 2008 and July 2016. Patients' charts were reviewed. Patients were queried by telephone and by mail at time of follow-up (FU)...
September 19, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28924192/short-chain-fatty-acids-ameliorate-immune-mediated-uveitis-partially-by-altering-migration-of-lymphocytes-from-the-intestine
#4
Yukiko K Nakamura, Cathleen Janowitz, Christina Metea, Mark Asquith, Lisa Karstens, James T Rosenbaum, Phoebe Lin
Short chain fatty acids (SCFA) are metabolites of intestinal bacteria resulting from fermentation of dietary fiber. SCFA are protective in various animal models of inflammatory disease. We investigated the effects of exogenous administration of SFCAs, particularly propionate, on uveitis using an inducible model of experimental autoimmune uveitis (EAU). Oral SCFA administration attenuated uveitis severity in a mouse strain-dependent manner through regulatory T cell induction among lymphocytes in the intestinal lamina propria (LPL) and cervical lymph nodes (CLN)...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923843/do-we-need-to-reconsider-best-practice-in-goal-setting-for-physical-activity-promotion
#5
EDITORIAL
Christian Swann, Simon Rosenbaum
No abstract text is available yet for this article.
September 18, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28920711/rivaroxaban-causes-missed-diagnosis-of-protein-s-deficiency-but-not-of-activated-protein-c-resistance-factor-v-leiden
#6
Elena Maryamchik, Matthew W Rosenbaum, Elizabeth M Van Cott
CONTEXT: - Rivaroxaban causes a false increase in activated protein C resistance (APCR) ratios and protein S activity. OBJECTIVE: - To investigate whether this increase masks a diagnosis of factor V Leiden (FVL) or protein S deficiency in a "real-world" population of patients undergoing rivaroxaban treatment and hypercoagulation testing. DESIGN: - During a 2.5-year period, we compared 4 groups of patients (n = 60): FVL heterozygous (FVL-HET)/taking rivaroxaban, wild-type/taking rivaroxaban, FVL-HET/no rivaroxaban, and normal APCR/no rivaroxaban...
September 18, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28919716/palatability-and-physical-properties-of-potassium-binding-resin-rdx7675-comparison-with-sodium-polystyrene-sulfonate
#7
Vanessa Zann, John McDermott, Jeffrey W Jacobs, James P Davidson, Fangling Lin, Paul Korner, Robert C Blanks, David P Rosenbaum
BACKGROUND: Hyperkalemia is a potentially life-threatening condition that patients with heart failure or chronic kidney disease, especially those taking renin-angiotensin-aldosterone system inhibitors, are at high risk of developing. Sodium polystyrene sulfonate (SPS), a current treatment, binds potassium within the gastrointestinal tract to reduce potassium absorption. However, poor palatability limits its long-term use. RDX7675, a novel potassium binder in development for the treatment of hyperkalemia, is a calcium salt of a reengineered polystyrene sulfonate-based resin designed to have enhanced palatability...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28916013/the-emergency-department-challenges-and-opportunities-for-suicide-prevention
#8
REVIEW
Joan Rosenbaum Asarnow, Kalina Babeva, Elizabeth Horstmann
Emergency departments (EDs) can offer life-saving suicide prevention care. This article focuses on the ED and emergency services as service delivery sites for suicide prevention. Characteristics of EDs, models of emergency care, ED screening and brief intervention models, and practice guidelines and parameters are reviewed. A care process model for youths at risk for suicide and self-harm is presented, with guidance for clinicians based on the scientific evidence. Strengthening emergency infrastructure and integrating effective suicide prevention strategies derived from scientific research are critical for advancing suicide prevention objectives...
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28906316/secondary-loss-of-response-to-infliximab-in-pediatric-crohn-s-disease-does-it-matter-how-and-when-we-start
#9
Rishi Bolia, Jeremy Rosenbaum, Vered Schildkraut, Winita Hardikar, Mark Oliver, Donald Cameron, George Alex
OBJECTIVES: A significant proportion of children with Crohn's disease develop a secondary loss of response (LOR) to infliximab. Our aim was to study the impact of initial treatment strategies on secondary LOR. METHODS: We reviewed the medical records of children with Crohn's disease who received scheduled maintenance infliximab therapy for at least 12 months. We compared children who developed LOR with those who did not; with regards to their clinical and laboratory parameters, disease phenotype and treatment strategy before developing LOR...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28902570/tragedy-perseverance-and-chance-the-story-of-car-t-therapy
#10
Lisa Rosenbaum
In 2010, 5-year-old Emily Whitehead was diagnosed with acute lymphoblastic leukemia (ALL). Though her parents were told that if you had to have a kid with cancer, ALL was the best one to have, Emily’s course was hardly typical. After two rounds of chemotherapy, necrotizing fasciitis developed in..
September 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28880966/the-prolyl-4-hydroxylase-inhibitor-gsk360a-decreases-post-stroke-brain-injury-and-sensory-motor-and-cognitive-behavioral-deficits
#11
Jin Zhou, Jie Li, Daniel M Rosenbaum, Jian Zhuang, Carrie Poon, Pu Qin, Katrina Rivera, John Lepore, Robert N Willette, Erding Hu, Frank C Barone
There is interest in pharmacologic preconditioning for end-organ protection by targeting the HIF system. This can be accomplished by inhibition of prolyl 4-hydroxylase (PHD). GSK360A is an orally active PHD inhibitor that has been previously shown to protect the failing heart. We hypothesized that PHD inhibition can also protect the brain from injuries and resulting behavioral deficits that can occur as a result of surgery. Thus, our goal was to investigate the effect of pre-stroke surgery brain protection using a verified GSK360A PHD inhibition paradigm on post-stroke surgery outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28873039/especial-skills-in-experienced-archers
#12
Mahdi Nabavinik, Ali Abaszadeh, Mehrab Mehranmanesh, David A Rosenbaum
Especial skills are skills that are distinctive by virtue of massive practice within the narrow contexts in which they are expressed. In the first demonstration of especial skills, Keetch, Schmidt, Lee, and Young (2005) showed that experienced basketball players are better at shooting baskets from the foul line, where they had massive amounts of practice, than would expected from their success at other locations closer to or farther from the basket. Similar results were obtained for baseball throwing. The authors asked whether especial skills hold in archery, a sport requiring less movement...
September 5, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28872939/psychometric-evaluation-of-the-young-children-s-participation-and-environment-measure-yc-pem-for-use-in-singapore
#13
Chun Yi Lim, Mary Law, Mary Khetani, Peter Rosenbaum, Nancy Pollock
AIMS: To estimate the psychometric properties of a culturally adapted version of the Young Children's Participation and Environment Measure (YC-PEM) for use among Singaporean families. METHODS: This is a prospective cohort study. Caregivers of 151 Singaporean children with (n = 83) and without (n = 68) developmental disabilities, between 0 and 7 years, completed the YC-PEM (Singapore) questionnaire with 3 participation scales (frequency, involvement, and change desired) and 1 environment scale for three settings: home, childcare/preschool, and community...
September 5, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/28865497/exercise-as-an-essential-therapeutic-tool-in-mental-health-closing-the-gap-from-research-to-practice-a-portuguese-perspective
#14
Lara Carneiro, Simon Rosenbaum, Maria Paula Mota, Felipe Schuch, Philip B Ward, José Vasconcelos-Raposo
No abstract text is available yet for this article.
May 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28863814/multiple-mechanisms-of-regulation-of-transient-receptor-potential-ion-channels-by-cholesterol
#15
Sara L Morales-Lázaro, Tamara Rosenbaum
The transient receptor potential (TRP) family of ion channels is constituted by several nonselective cation channels that are activated by diverse stimuli and that function as polymodal receptors. TRP ion channels are expressed in neural and nonneural tissues where they play important roles in cell physiology. The activation of these ion channels is achieved through changes in temperature, osmolarity, voltage, pH, pressure, and by some natural or synthetic chemical compounds that directly bind to these proteins to regulate their activity...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28863386/from-the-statistics-of-connectivity-to-the-statistics-of-spike-times-in-neuronal-networks
#16
REVIEW
Gabriel Koch Ocker, Yu Hu, Michael A Buice, Brent Doiron, Krešimir Josić, Robert Rosenbaum, Eric Shea-Brown
An essential step toward understanding neural circuits is linking their structure and their dynamics. In general, this relationship can be almost arbitrarily complex. Recent theoretical work has, however, begun to identify some broad principles underlying collective spiking activity in neural circuits. The first is that local features of network connectivity can be surprisingly effective in predicting global statistics of activity across a network. The second is that, for the important case of large networks with excitatory-inhibitory balance, correlated spiking persists or vanishes depending on the spatial scales of recurrent and feedforward connectivity...
August 29, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28859188/medication-and-cognitive-behavioral-therapy-for-pediatric-anxiety-disorders-no-need-for-anxiety-in-treating-anxiety
#17
Joan Rosenbaum Asarnow, Michelle S Rozenman, Gabrielle A Carlson
No abstract text is available yet for this article.
August 31, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28858658/physical-activity-and-suicidal-ideation-a-systematic-review-and-meta-analysis
#18
REVIEW
Davy Vancampfort, Mats Hallgren, Joseph Firth, Simon Rosenbaum, Felipe B Schuch, James Mugisha, Michel Probst, Tine Van Damme, André F Carvalho, Brendon Stubbs
BACKGROUND: A potential approach to suicide prevention that has not been closely examined, but which holds promise in terms of widespread dissemination without major side-effects, is physical activity (PA). This systematic review and meta-analysis set out to: (a) explore associations between PA and suicidal ideation (SI) levels, and (b) investigate the effect of PA interventions on SI. METHODS: Major electronic databases were searched from inception up to 05/2017 to identify quantitative studies reporting an association between PA and SI...
August 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28858524/reversible-dimerization-of-polymeric-amphiphiles-acts-as-a-molecular-switch-of-enzymatic-degradability
#19
Ido Rosenbaum, Ram Avinery, Assaf J Harnoy, Gadi Slor, Einat Tirosh, Uri Hananel, Roy Beck, Roey J Amir
Enzyme-responsive polymeric micelles have great potential as drug delivery systems due to the high selectivity and overexpression of disease-associated enzymes, which could be utilized to trigger the release of active drugs only at the target site. We previously demonstrated that enzymatic degradation rates of amphiphilic PEG-dendron hybrids could be precisely tuned by gradually increasing the hydrophobic to hydrophilic ratio. However, with the increase in hydrophobicity, the micelles rapidly became too stable and could not be degraded, as often encountered for many other amphiphilic assemblies...
September 22, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28854237/tumor-engraftment-in-patient-derived-xenografts-of-pancreatic-ductal-adenocarcinoma-is-associated-with-adverse-clinicopathological-features-and-poor-survival
#20
Ilaria Pergolini, Vicente Morales-Oyarvide, Mari Mino-Kenudson, Kim C Honselmann, Matthew W Rosenbaum, Sabikun Nahar, Marina Kem, Cristina R Ferrone, Keith D Lillemoe, Nabeel Bardeesy, David P Ryan, Sarah P Thayer, Andrew L Warshaw, Carlos Fernández-Del Castillo, Andrew S Liss
Patient-derived xenograft (PDX) tumors are powerful tools to study cancer biology. However, the ability of PDX tumors to model the biological and histological diversity of pancreatic ductal adenocarcinoma (PDAC) is not well known. In this study, we subcutaneously implanted 133 primary and metastatic PDAC tumors into immunodeficient mice. Fifty-seven tumors were successfully engrafted and even after extensive passaging, the histology of poorly-, moderately-, and well-differentiated tumors was maintained in the PDX models...
2017: PloS One
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