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https://www.readbyqxmd.com/read/29148079/insm1-a-novel-nuclear-marker-in-merkel-cell-carcinoma-cutaneous-neuroendocrine-carcinoma
#1
Patrick S Rush, Jason N Rosenbaum, Madhuchhanda Roy, Rebecca M Baus, Daniel D Bennett, Ricardo V Lloyd
Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma, and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype the diagnosis can be challenging...
November 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29134645/the-yin-and-yang-of-clinical-research
#2
EDITORIAL
Peter Rosenbaum
No abstract text is available yet for this article.
December 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29122577/inter-observer-agreement-among-uveitis-experts-on-uveitic-diagnoses-the-standardization-of-uveitis-nomenclature-sun-experience
#3
Douglas A Jabs, Andrew Dick, John T Doucette, Amod Gupta, Susan Lightman, Peter McCluskey, Annabelle A Okada, Alan G Palestine, James T Rosenbaum, Sophia M Saleem, Jennifer Thorne, Brett Trusko
PURPOSE: To evaluate the interobserver agreement among uveitis experts on the diagnosis of the specific uveitic disease. DESIGN: Inter-observer agreement analysis METHODS: Five committees, each of 9 individuals, working in parallel, reviewed cases from a preliminary database of 25 uveitic diseases, collected by disease, and voted independently online whether the case was the disease in question or not. The agreement statistic, κ, was calculated for the 36 pairwise comparisons for each disease, and a mean κ was calculated for each disease...
November 6, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29118499/causes-and-management-of-small-pupil-in-patients-with-cataract
#4
Ioannis Halkiadakis, Irini Chatziralli, Evangelos Drakos, Michail Katzakis, Sotirios Skouriotis, Eleni Patsea, Panagiotis Mitropoulos, Artemios Kandarakis
BACKGROUND: The purpose of the study was to present the causes and management of small pupil (<6 mm) in Greek patients with cataract. METHODS: About 1144 consecutive patients with cataract comprised the study group. The pupil size was measured after maximal dilation by means of Rosenbaum cards and Colvard pupillometer. Dilation regimen included phenylephrine 10%, tropicamide 1%, cyclopentolate 1%, and ketorolac trometamol 0.5% administered 3 times at 5 min intervals starting 1 h before surgery...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29116613/how-are-cognitive-and-physical-difficulty-compared
#5
Cory Adam Potts, Stefan Pastel, David A Rosenbaum
Tasks that require less physical effort are generally preferred over more physically demanding alternatives. Similarly, tasks that require less mental effort are generally preferred over more mentally demanding alternatives. But what happens when one must choose between tasks that entail different kinds of effort, one mainly physical (e.g., carrying buckets) and the other mainly mental (e.g., counting)? We asked participants to choose between a bucket-carrying task and a counting task. Our participants were less likely to choose the bucket task when it required a long reach rather than a short reach, and our participants were also less likely to choose the bucket task the smaller the final count value...
November 7, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29114013/nanopore-sequencing-comes-to-plant-genomes
#6
Nancy Rosenbaum Hofmann
No abstract text is available yet for this article.
November 7, 2017: Plant Cell
https://www.readbyqxmd.com/read/29113943/effect-of-aerobic-exercise-on-hippocampal-volume-in-humans-a-systematic-review-and-meta-analysis
#7
Joseph Firth, Brendon Stubbs, Davy Vancampfort, Felipe Schuch, Jim Lagopoulos, Simon Rosenbaum, Philip B Ward
Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes in humans, and applied meta-analytic techniques to determine if aerobic exercise resulted in volumetric increases. We also sought to establish how volume changes differed in relation to unilateral measures of left/right hippocampal volume, and across the lifespan...
November 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/29108789/mauricio-b-rosenbaum-and-the-argentinian-school-of-electrocardiography
#8
Marcelo V Elizari
No abstract text is available yet for this article.
October 16, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29105760/should-the-gross-motor-function-classification-system-be-used-for-children-who-do-not-have-cerebral-palsy
#9
REVIEW
Megan Towns, Peter Rosenbaum, Robert Palisano, F Virginia Wright
This literature review addressed four questions. (1) In which populations other than cerebral palsy (CP) has the Gross Motor Function Classification System (GMFCS) been applied? (2) In what types of study, and why was it used? (3) How was it modified to facilitate these applications? (4) What justifications and evidence of psychometric adequacy were used to support its application? A search of PubMed, MEDLINE, and Embase databases (January 1997 to April 2017) using the terms: 'GMFCS' OR 'Gross Motor Function Classification System' yielded 2499 articles...
November 5, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29101423/risk-of-lower-limb-amputation-in-a-national-prevalent-cohort-of-patients-with-diabetes
#10
Jason K Gurney, James Stanley, Steve York, Dieter Rosenbaum, Diana Sarfati
AIMS/HYPOTHESIS: Lower limb amputation is a serious complication of diabetes mellitus. Understanding how amputation risk differs by population subgroups is crucial in terms of directing preventive strategies. In this study, we describe those factors that impact amputation risk in the entire prevalent diabetic population of New Zealand. METHODS: A national prevalent cohort of 217,207 individuals with diabetes in 2010 were followed up until the end of 2013 for lower limb amputations, and 2014 for mortality...
November 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/29101009/uveitis-and-juvenile-psoriatic-arthritis-or-psoriasis
#11
Sherveen S Salek, Archana Pradeep, Catherine Guly, Athimalaipet V Ramanan, James T Rosenbaum
PURPOSE: To describe the phenotype of the uveitis that accompanies juvenile psoriatic arthritis or psoriasis. DESIGN: Observational case series METHODS: Setting: Two university based referral clinics, one in England, one in the US. STUDY POPULATION: Five children with uveitis and psoriatic arthritis and one with uveitis and psoriasis. OBSERVATIONAL PROCEDURE: Retrospective chart review. MAIN OUTCOME MEASURES: Demographics of subjects such as age and sex; description of ocular and joint disease; surgical and other complications; medical treatment...
October 31, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29099816/is-betahistine-effective-for-m%C3%A3-ni%C3%A3-re%C3%A2-s-disease
#12
Andrés Rosenbaum, Matías Winter
PROBLEM: Meniere’s disease is an inner ear disorder characterized by episodes of spontaneous vertigo, fluctuating hearing loss and tinnitus. Betahistine has been used to reduce intensity and frecuency of vertigo attacks, but there is controversy regarding its effectiveness. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
October 31, 2017: Medwave
https://www.readbyqxmd.com/read/29091553/understanding-the-planned-parenthood-divide-albert-lasker-and-women-s-health
#13
Lisa Rosenbaum
Albert Lasker, considered the "father of modern advertising," transformed product marketing from an endeavor based on the simple presentation of facts to one finely tuned to consumer psychology, particularly as it pertained to women. At a time when discussion of menstruation was taboo, for example,..
November 1, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29080670/central-ghrelin-receptor-stimulation-modulates-sex-motivation-in-male-rats-in-a-site-dependent-manner
#14
Lindsay Hyland, Stephanie Rosenbaum, Alexander Edwards, Daniel Palacios, M Dean Graham, James G Pfaus, Barbara Woodside, Alfonso Abizaid
Ghrelin, a hormone produced primarily by the stomach, has been associated with motivational processes that include reward-seeking behaviors. In male laboratory mice, elevation of ghrelin levels enhances some aspects of sexual motivation and behavior, whereas in other experiments with male mice, rats, and other species, ghrelin treatment or food deprivation decreases sexual motivation and/or behavior. The present tested the hypothesis that stimulation of ghrelin receptors in different brain regions have opposite effects on male sexual motivation and behavior...
November 8, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29074727/liver-reptin-ruvbl2-controls-glucose-and-lipid-metabolism-with-opposite-actions-on-mtorc1-and-mtorc2-signalling
#15
Joaquim Javary, Nathalie Allain-Courtois, Nicolas Saucisse, Pierre Costet, Capucine Heraud, Fadila Benhamed, Rémi Pierre, Corinne Bure, Nestor Pallares-Lupon, Marcio Do Cruzeiro, Catherine Postic, Daniela Cota, Pierre Dubus, Jean Rosenbaum, Samira Benhamouche-Trouillet
OBJECTIVE: The AAA+ ATPase Reptin is overexpressed in hepatocellular carcinoma and preclinical studies indicate that it could be a relevant therapeutic target. However, its physiological and pathophysiological roles in vivo remain unknown. This study aimed to determine the role of Reptin in mammalian adult liver. DESIGN AND RESULTS: We generated an inducible liver-specific Reptin knockout (Repin(LKO) ) mouse model. Following Reptin invalidation, mice displayed decreased body and fat mass, hypoglycaemia and hypolipidaemia...
October 26, 2017: Gut
https://www.readbyqxmd.com/read/29074308/second-order-grasp-planning-reflects-sensitivity-to-inertial-factors
#16
Jeffrey B Wagman, Drew H Abney, David A Rosenbaum
Previous studies have shown that people's grasps of objects are tuned to the objects' inertial properties. In most of those studies, information obtained about the attunement of the grasps to the objects' inertial properties was limited to first-order grasp planning (i.e., planning of grasps based on immediate task demands). We investigated attunement of grasps to an object's inertial properties in the context of second-order grasp planning (i.e., planning of grasps based on subsequent task demands). In Experiment 1, participants grasped a horizontal rod whose right or left end would be brought down onto a target...
October 23, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29072894/medicaid-payment-and-delivery-system-reform-early-insights-from-10-medicaid-expansion-states
#17
Sara Rosenbaum, Sara Schmucker, Sara Rothenberg, Rachel Gunsalus, J Zoe Beckerman
Issue: Expanded Medicaid enrollment under the Affordable Care Act has heightened the importance of states’ roles as principal purchasers of health care for low-income and medically vulnerable populations. Concurrently, the federal government has augmented states’ purchasing tools. Goal: To examine the evolution of payment and delivery system reform in 10 ACA Medicaid expansion states. Methods: Analysis of state managed care policies, including a detailed review of purchasing documents as well as interviews with senior agency officials in 10 states...
October 1, 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/29071400/microbial-electrosynthesis-i-pure-and-defined-mixed-culture-engineering
#18
Miriam A Rosenbaum, Carola Berger, Simone Schmitz, Ronny Uhlig
In the past 6 years, microbial bioelectrochemistry has strongly increased in attraction and audience when expanding from mainly environmental technology applications to biotechnology. In particular, the promise to combine electrosynthesis with microbial catalysis opens attractive approaches for new sustainable redox-cofactor recycling, redox-balancing, or even biosynthesis processes. Much of this promise is still not fulfilled, but it has opened and fueled entirely new research areas in this discipline. Activities in designing, tailoring, and applying specific microbial catalysts as pure or defined co-cultures for defined target bioproductions are greatly accelerating...
October 26, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29069727/a-global-comparison-of-the-cost-of-patented-cancer-drugs-in-relation-to-global-differences-in-wealth
#19
Daniel A Goldstein, Jonathon Clark, Yifan Tu, Jie Zhang, Fenqi Fang, Robert Goldstein, Salomon M Stemmer, Eli Rosenbaum
INTRODUCTION: There are major differences in cancer drug prices around the world. However, the patterns of affordability of these drugs are poorly understood. The objective of this study was to compare patterns of affordability of cancer drugs in Australia, China, India, Israel, South Africa, the United Kingdom, and the United States. RESULTS: Cancer drug prices are highest in the United States. Cancer drugs are the least affordable in India by a large margin. Despite lower prices than in the USA, cancer drugs are less affordable in middle-income countries than in high-income countries...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29069474/the-validity-and-value-of-self-reported-physical-activity-and-accelerometry-in-people-with-schizophrenia-a-population-scale-study-of-the-uk-biobank
#20
Joseph Firth, Brendon Stubbs, Davy Vancampfort, Felipe B Schuch, Simon Rosenbaum, Philip B Ward, Josh A Firth, Jerome Sarris, Alison R Yung
Background: Previous physical activity (PA) research in schizophrenia has relied largely upon self-report measures. However, the accuracy of this method is questionable. Obtaining accurate measurements, and determining what may influence PA levels in schizophrenia, is essential to understand physical inactivity in this population. This study examined differences in self-reported and objectively measured PA in people with schizophrenia and the general population using a large, population-based dataset from the UK Biobank...
October 24, 2017: Schizophrenia Bulletin
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