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https://www.readbyqxmd.com/read/29338849/the-challenge-of-blau-syndrome
#1
EDITORIAL
Gary N Holland, James T Rosenbaum
No abstract text is available yet for this article.
January 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29329988/rethinking-medicaid-coverage-and-payment-policy-to-promote-high-value-care-the-case-of-long-acting-reversible-contraception
#2
Veronica X Vela, Elizabeth W Patton, Darshak Sanghavi, Susan F Wood, Peter Shin, Sara Rosenbaum
CONTEXT: Long-acting reversible contraception (LARC) is the most effective reversible method to prevent unplanned pregnancies. Variability in state-level policies and the high cost of LARC could create substantial inconsistencies in Medicaid coverage, despite federal guidance aimed at enhancing broad access. This study surveyed state Medicaid payment policies and outreach activities related to LARC to explore the scope of services covered. METHODS: Using publicly available information, we performed a content analysis of state Medicaid family planning and LARC payment policies...
January 9, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29327716/genomic-heterogeneity-of-alk-fusion-breakpoints-in-non-small-cell-lung-cancer
#3
Jason N Rosenbaum, Ryan Bloom, Jason T Forys, Jeff Hiken, Jon R Armstrong, Julie Branson, Samantha McNulty, Priya D Velu, Kymberlie Pepin, Haley Abel, Catherine E Cottrell, John D Pfeifer, Shashikant Kulkarni, Ramaswamy Govindan, Eric Q Konnick, Christina M Lockwood, Eric J Duncavage
In lung adenocarcinoma, canonical EML4-ALK inversion results in a fusion protein with a constitutively active ALK kinase domain. Evidence of ALK rearrangement occurs in a minority (2-7%) of lung adenocarcinoma, and only ~60% of these patients will respond to targeted ALK inhibition by drugs such as crizotinib and ceritinib. Clinically, targeted anti-ALK therapy is often initiated based on evidence of an ALK genomic rearrangement detected by fluorescence in situ hybridization (FISH) of interphase cells in formalin-fixed, paraffin-embedded tissue sections...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29327057/distinguishing-uveitis-secondary-to-sarcoidosis-from-idiopathic-disease-cardiac-implications
#4
Yong Seop Han, Erick Rivera-Grana, Sherveen Salek, James T Rosenbaum
Importance: Idiopathic disease is the most frequent diagnosis in a uveitis clinic. The need to distinguish sarcoidosis from idiopathic uveitis is controversial. However, cardiac involvement in sarcoidosis can be life-threatening. Objective: To report a series of patients with uveitis and cardiac sarcoidosis to illustrate the importance of categorizing the causes of uveitis. Design, Setting, and Participants: This retrospective observational case series reviewed the medical records of 249 patients with uveitis who were referred to the Casey Eye Institute between July 1, 2008, and February 28, 2017...
January 11, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29318689/now-welfare-reform-of-course
#5
Sara Rosenbaum
No abstract text is available yet for this article.
January 10, 2018: Milbank Quarterly
https://www.readbyqxmd.com/read/29315144/tender-subcutaneous-fluctuant-forehead-nodule-an-unexpected-foray-into-the-cranium
#6
Lara E Rosenbaum, Michael R Migden
No abstract text is available yet for this article.
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29310963/guidance-on-noncorticosteroid-systemic-immunomodulatory-therapy-in-noninfectious-uveitis-fundamentals-of-care-for-uveitis-focus-initiative
#7
REVIEW
Andrew D Dick, James T Rosenbaum, Hassan A Al-Dhibi, Rubens Belfort, Antoine P Brézin, Soon Phaik Chee, Janet L Davis, Athimalaipet V Ramanan, Koh-Hei Sonoda, Ester Carreño, Heloisa Nascimento, Sawsen Salah, Sherveen Salek, Jay Siak, Laura Steeples
TOPIC: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. CLINICAL RELEVANCE: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. METHODS: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science)...
January 6, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29290338/genotype-phenotype-correlation-in-nf1-evidence-for-a-more-severe-phenotype-associated-with-missense-mutations-affecting-nf1-codons-844-848
#8
Magdalena Koczkowska, Yunjia Chen, Tom Callens, Alicia Gomes, Angela Sharp, Sherrell Johnson, Meng-Chang Hsiao, Zhenbin Chen, Meena Balasubramanian, Christopher P Barnett, Troy A Becker, Shay Ben-Shachar, Debora R Bertola, Jaishri O Blakeley, Emma M M Burkitt-Wright, Alison Callaway, Melissa Crenshaw, Karin S Cunha, Mitch Cunningham, Maria D D'Agostino, Karin Dahan, Alessandro De Luca, Anne Destrée, Radhika Dhamija, Marica Eoli, D Gareth R Evans, Patricia Galvin-Parton, Jaya K George-Abraham, Karen W Gripp, Jose Guevara-Campos, Neil A Hanchard, Concepcion Hernández-Chico, LaDonna Immken, Sandra Janssens, Kristi J Jones, Beth A Keena, Aaina Kochhar, Jan Liebelt, Arelis Martir-Negron, Maurice J Mahoney, Isabelle Maystadt, Carey McDougall, Meriel McEntagart, Nancy Mendelsohn, David T Miller, Geert Mortier, Jenny Morton, John Pappas, Scott R Plotkin, Dinel Pond, Kenneth Rosenbaum, Karol Rubin, Laura Russell, Lane S Rutledge, Veronica Saletti, Rhonda Schonberg, Allison Schreiber, Meredith Seidel, Elizabeth Siqveland, David W Stockton, Eva Trevisson, Nicole J Ullrich, Meena Upadhyaya, Rick van Minkelen, Helene Verhelst, Margaret R Wallace, Yoon-Sim Yap, Elaine Zackai, Jonathan Zonana, Vickie Zurcher, Kathleen Claes, Yolanda Martin, Bruce R Korf, Eric Legius, Ludwine M Messiaen
Neurofibromatosis type 1 (NF1), a common genetic disorder with a birth incidence of 1:2,000-3,000, is characterized by a highly variable clinical presentation. To date, only two clinically relevant intragenic genotype-phenotype correlations have been reported for NF1 missense mutations affecting p.Arg1809 and a single amino acid deletion p.Met922del. Both variants predispose to a distinct mild NF1 phenotype with neither externally visible cutaneous/plexiform neurofibromas nor other tumors. Here, we report 162 individuals (129 unrelated probands and 33 affected relatives) heterozygous for a constitutional missense mutation affecting one of five neighboring NF1 codons-Leu844, Cys845, Ala846, Leu847, and Gly848-located in the cysteine-serine-rich domain (CSRD)...
January 4, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29288850/angiographic-blush-after-stereotactic-radiosurgery-ablation-of-a-residual-arteriovenous-malformation-in-a-pediatric-patient-case-report-and-review-of-the-literature
#9
C C Szujewski, D M Heiferman, M D Rosenbaum, M R Reynolds, D E Anderson, J C Serrone
No abstract text is available yet for this article.
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29288789/see-do-teach-a-review-of-contemporary-literature-and-call-to-action-for-communication-skills-teaching-in-urology
#10
Kathleen Kieran, Norman M Jensen, Marcy Rosenbaum
OBJECTIVE: To assess the current state of published literature on communication skill teaching in urology in order to inform future directions for research and teaching. Excellent patient-physician communication skills increase understanding of medical conditions, facilitate shared decision making regarding treatment planning, improve clinical outcomes, and decrease lawsuits. Surgical and procedure-based subspecialties, including urology, have generally been slow to incorporate formal communication skill teaching into curricula for postgraduate trainees...
December 27, 2017: Urology
https://www.readbyqxmd.com/read/29287307/effects-of-hla-b27-on-gut-microbiota-in-experimental-spondyloarthritis-implicate-an-ecological-model-of-dysbiosis
#11
Tejpal Gill, Mark Asquith, Stephen R Brooks, James T Rosenbaum, Robert A Colbert
OBJECTIVES: We investigated whether HLA-B27-mediated experimental spondyloarthritis (SpA) is associated with a common gut microbial signature to identify potential drivers of pathogenesis. METHODS: Effects of HLA-B27 on three genetic backgrounds, Dark Agouti (DA), Lewis, and Fischer were compared, using wild-type littermates and HLA-B7 transgenic Lewis rats as controls. At 2, 3-4, and 6-8 months of age, cecal and colonic tissue or contents were analyzed by histology for inflammation, RNA-Seq for gene expression differences, and 16S rRNA gene sequencing for microbiota differences...
December 29, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29281504/swallowing-a-spy-the-potential-uses-of-digital-adherence-monitoring
#12
Lisa Rosenbaum
I recently cared for a middle-aged woman, Ms. G. who presented with an acute coronary syndrome. Some years ago, she’d had a cardiac arrest and was found to have extensive coronary artery disease, for which she underwent urgent multivessel coronary-artery bypass surgery. Though we often assume that..
January 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29279890/atypical-cause-of-typical-hypertensive-intracranial-bleeding
#13
Sujan T Reddy, David Rosenbaum, Sunil A Sheth
No abstract text is available yet for this article.
December 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29274500/cortical-hemodynamic-changes-during-the-trier-social-stress-test-a-fnirs-study
#14
David Rosenbaum, Paula Hilsendegen, Mara Thomas, Florian B Haeussinger, Florian G Metzger, Hans-Christoph Nuerk, Andreas J Fallgatter, Vanessa Nieratschker, Ann-Christine Ehlis
The study of the stress response has been of great interest in the last decades due to its relationship to physical and mental health. Along with the technological progress in the neurosciences, different methods of stress induction have been developed for the special requirements regarding the acquisition of neuroimaging data. However, these paradigms often differ from ecologically valid stress inductions such as the Trier Social Stress Test (TSST) in substantial ways. In the study at hand, we used the rather robust optical imaging method of functional Near-infrared Spectroscopy (fNIRS) to assess brain activation during the TSST and two non-stressful control conditions...
December 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/29260107/recovery-of-outer-retinal-laminations-on-optical-coherence-tomography-after-treatment-of-cancer-associated-retinopathy
#15
Francisco J Irizarry, Laura J Kopplin, Sherveen S Salek, Grazyna Adamus, Mohamed Saleh, Kristin Biggee, Phoebe Lin, James T Rosenbaum
Purpose: To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy. Observations: An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82-84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29249594/anatomic-versus-metabolic-tumor-response-assessment-after-radioembolization-treatment
#16
Jennifer M J Jongen, Charlotte E N M Rosenbaum, Manon N G J A Braat, Maurice A A J van den Bosch, Daniel Y Sze, Onno Kranenburg, Inne H M Borel Rinkes, Marnix G E H Lam, Andor F van den Hoven
PURPOSE: To assess applicability of metabolic tumor response assessment on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) after radioembolization (RE) in patients with colorectal liver metastases (CRLM) by comparison with one-dimensional size-based response assessment on MR imaging. MATERIALS AND METHODS: This prospective cohort study comprised 38 patients with CRLM undergoing RE. MR imaging and 18F-FDG PET/CT imaging were performed at baseline, 1 month (n = 38), and 3 months (n = 21)...
December 14, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29246979/dissociable-contributions-of-thalamic-nuclei-to-recognition-memory-novel-evidence-from-a-case-of-medial-dorsal-thalamic-damage
#17
Rachel N Newsome, Alexandra N Trelle, Celia Fidalgo, Bryan Hong, Victoria M Smith, Alexander Jacob, Jennifer D Ryan, R Shayna Rosenbaum, Rosemary A Cowell, Morgan D Barense
The thalamic nuclei are thought to play a critical role in recognition memory. Specifically, the anterior thalamic nuclei and medial dorsal nuclei may serve as critical output structures in distinct hippocampal and perirhinal cortex systems, respectively. Existing evidence indicates that damage to the anterior thalamic nuclei leads to impairments in hippocampal-dependent tasks. However, evidence for the opposite pattern following medial dorsal nuclei damage has not yet been identified. In the present study, we investigated recognition memory in NC, a patient with relatively selective medial dorsal nuclei damage, using two object recognition tests with similar foils: a yes/no (YN) test that requires the hippocampus, and a forced choice corresponding test (FCC) that is supported by perirhinal cortex...
January 2018: Learning & Memory
https://www.readbyqxmd.com/read/29246485/autobiographical-memory-from-experiences-to-brain-representations
#18
EDITORIAL
Asaf Gilboa, Shayna Rosenbaum, Avi Mendelsohn
No abstract text is available yet for this article.
December 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29246393/effect-of-repeat-prostate-biopsies-on-functional-outcomes-after-radical-prostatectomy
#19
Clemens M Rosenbaum, Philipp Mandel, Pierre Tennstedt, Felix Preisser, Phillip Marks, Felix K-H Chun, Markus Graefen, Derya Tilki, Georg Salomon
PURPOSE: Growing acceptance of active surveillance (AS) results in a relevant number of patients who will undergo radical prostatectomy (RP) after multiple biopsy sessions (Bx) due to cancer progression. The effect of repeat Bx on functional outcomes after RP remains controversial. METHODS: Overall, 11,140 patients who underwent RP from 2007 to 2015 were analyzed. Number of Bx sessions (1 vs. 2 vs. ≥3) before RP was examined. Association between number of Bx sessions and erectile dysfunction (ED) and urinary incontinence (UI) was assessed by univariable and multivariable logistic regressions...
December 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29236644/the-less-is-more-crusade-are-we-overmedicalizing-or-oversimplifying
#20
Lisa Rosenbaum
They called me Ms. Appropriate. When I was a cardiology fellow, health care costs were skyrocketing, and I considered devoting my career to curbing inappropriate use of medical resources. My first target, as a supervisor of cardiac stress tests, was referrals of patients for unnecessary testing —..
December 14, 2017: New England Journal of Medicine
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