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https://www.readbyqxmd.com/read/27893495/integration-of-eeg-into-psychiatric-practice-a-step-toward-precision-medicine-for-autism-spectrum-disorder
#1
Ronald J Swatzyna, Jay D Tarnow, Robert P Turner, Alexandra J Roark, Erin K MacInerney, Gerald P Kozlowski
INTRODUCTION: Data from an EEG is not commonly used by psychiatrists to plan treatment and medication. However, EEG abnormalities such as isolated epileptiform discharges (IEDs) are found to be more prevalent in psychiatric patients, particularly those diagnosed with Autism Spectrum Disorder (ASD). Most medications prescribed for ASD lower seizure threshold and increase side-effects. Therefore, it may be prudent to order an EEG for ASD cases, especially those categorized as refractory...
November 22, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27817163/psychotropic-medication-use-among-insured-children-with-autism-spectrum-disorder
#2
Jeanne M Madden, Matthew D Lakoma, Frances L Lynch, Donna Rusinak, Ashli A Owen-Smith, Karen J Coleman, Virginia P Quinn, Vincent M Yau, Yinge X Qian, Lisa A Croen
This study examined psychotropic medication use among 7901 children aged 1-17 with autism spectrum disorder (ASD) in five health systems, comparing to matched cohorts with no ASD. Nearly half (48.5 %) of children with ASD received psychotropics in the year observed; the most common classes were stimulants, alpha-agonists, or atomoxetine (30.2 %), antipsychotics (20.5 %), and antidepressants (17.8 %). Psychotropic treatment was far more prevalent among children with ASD, as compared to children with no ASD (7...
November 5, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27738376/paroxetine-the-antidepressant-from-hell-probably-not-but-caution-required
#3
Robert M Nevels, Samuel T Gontkovsky, Bryman E Williams
Paroxetine, also known by the trade names Aropax, Paxil, Pexeva, Seroxat, Sereupin and Brisdelle, was first marketed in the U.S. in 1992. Effective for major depression and various anxiety disorders, it quickly gained a sizable share of the antidepressant prescription market. By the late 1990s, paroxetine frequently was being associated with serious drug interactions and medication side effects. Most significantly, in a major Canadian epidemiological study examining the relationship between antidepressants and diseases, paroxetine was associated with a 620 percent increase in the rate of breast cancer in women who had taken it over a four-year period...
March 1, 2016: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/27624381/use-of-psychotropic-drugs-in-patients-with-autism-spectrum-disorders-a-systematic-review
#4
K Jobski, J Höfer, F Hoffmann, C Bachmann
OBJECTIVE: The objective of this review was to examine prevalence and patterns of psychopharmacotherapy in individuals with autism spectrum disorder (ASD). METHOD: A systematic literature search in PubMed, CINAHL, and PsycINFO was performed, including articles published up to November 18, 2015. RESULTS: A total of 47 studies (data collection: 1976-2012), encompassing >300 000 individuals with ASD, were included. The prevalence of psychopharmacotherapy ranged from 2...
September 13, 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27591973/perinatal-exposure-to-the-selective-serotonin-reuptake-inhibitor-citalopram-alters-spatial-learning-and-memory-anxiety-depression-and-startle-in-sprague-dawley-rats
#5
Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhees
Selective serotonin reuptake inhibitors (SSRIs) block the serotonin (5-HT) reuptake transporter (SERT) and increase synaptic 5-HT. 5-HT is also important in brain development; hence when SSRIs are taken during pregnancy there exists the potential for these drugs to affect CNS ontogeny. Prenatal SSRI exposure has been associated with an increased prevalence of autism spectrum disorder (ASD), and peripheral 5-HT is elevated in some ASD patients. Perinatal SSRI exposure in rodents has been associated with increased depression and anxiety-like behavior, decreased sociability, and impaired learning in the offspring, behaviors often seen in ASD...
November 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27474253/autism-spectrum-disorder-and-prenatal-exposure-to-selective-serotonin-reuptake-inhibitors-a-systematic-review-and-meta-analysis
#6
Tohru Kobayashi, Tasuku Matsuyama, Masanobu Takeuchi, Shinya Ito
To obtain the risk estimates of autism spectrum disorder (ASD) in the offspring exposed to serotonin reuptake inhibitors (SSRI) in utero, we performed systematic review and meta-analysis of relevant studies. Five case-control and three cohort studies were eligible for the analysis. The SSRI group had significantly higher risk of ASD than the SSRI non-exposed group (pooled OR 1.45, 95% CI 1.15-1.82). In the subgroup analyses, however, the risk of ASD was similar between the SSRI group and other antidepressants group (pooled OR 1...
October 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27371348/proteomic-investigation-of-the-prefrontal-cortex-in-the-rat-clomipramine-model-of-depression
#7
Barbara Gellén, Katalin Völgyi, Balázs András Györffy, Boróka Balogh, Zsuzsa Darula, Hunyadi-Gulyás Éva, Péter Baracskay, András Czurkó, István Hernádi, Gábor Juhász, Árpád Dobolyi, Katalin Adrienna Kékesi
: Neonatal rodents chronically treated with the tricyclic antidepressant clomipramine show depression-like behavior, which persists throughout adulthood. Therefore, this animal model is suitable to investigate the pathomechanism of depression, which is still largely unknown at the molecular level beyond monoaminergic dysfunctions. Here, we describe protein level changes in the prefrontal cortex of neonatally clomipramine-treated adult rats correlating with behavioral abnormalities. Clomipramine was administered to rat pups twice daily between postnatal days 8-21, while controls received saline injections...
June 28, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27346512/autism-and-antidepressant-use-in-pregnancy
#8
Roy H Perlis
No abstract text is available yet for this article.
July 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27320508/-prevalence-of-the-use-of-psychoactive-medication-to-treat-young-persons-with-autism-spectrum-disorder-in-the-province-of-antwerp-belgium
#9
E Heyde, M Dhar, H Hellemans, E Schoentjes, D Van West
BACKGROUND: Very little information is available concerning the prevalence of the use of medication for treatment of individuals with autism spectrum disorder (ASD), particularly in European countries. Earlier studies have shown that a large number of patients with ASD use at least one psychoactive drug and that the numbers are increasing. Even in the nineties, studies suggested that the frequent use of psychoactive medication was widespread, although at the time there were only limited grounds for this assumption...
2016: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/27279529/an-introduction-to-the-psychopharmacology-of-children-and-adolescents-with-autism-spectrum-disorder
#10
Jason F Earle
TOPIC: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that requires a multidisciplinary approach to treatment. Psychopharmacology can play an important role within an array of services to help children and adolescents with ASD. PURPOSE: This article reviews the current evidence supporting the use of various psychiatric medications to treat common symptoms that often compromise functioning: severe irritability, interfering repetitive behaviors, ADHD, anxiety, depression, and sleep dysregulation...
May 2016: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/27244697/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children
#11
Pascal Bédard
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27244647/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children
#12
Yusuf Cem Kaplan, Elif Keskin-Arslan, Selin Acar
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27244224/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children-reply
#13
Anick Bérard, Takoua Boukhris
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27244054/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-the-children
#14
Eric Fombonne
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27243820/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children
#15
Adrienne Einarson, Carly Snyder, Gail Robinson
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27243632/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children
#16
Keith Fluegge
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27243468/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children
#17
Nicholas A Link, Mary E Temple-Cooper
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27243219/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children
#18
Alain Lesage, Fatoumata Binta Diallo
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27187441/epigenetic-effect-of-environmental-factors-on-autism-spectrum-disorders
#19
REVIEW
Takeo Kubota, Kazuki Mochizuki
Both environmental factors and genetic factors are involved in the pathogenesis of autism spectrum disorders (ASDs). Epigenetics, an essential mechanism for gene regulation based on chemical modifications of DNA and histone proteins, is also involved in congenital ASDs. It was recently demonstrated that environmental factors, such as endocrine disrupting chemicals and mental stress in early life, can change epigenetic status and gene expression, and can cause ASDs. Moreover, environmentally induced epigenetic changes are not erased during gametogenesis and are transmitted to subsequent generations, leading to changes in behavior phenotypes...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27138915/safety-of-selective-serotonin-reuptake-inhibitors-in-pregnancy-a-review-of-current-evidence
#20
REVIEW
Sura Alwan, Jan M Friedman, Christina Chambers
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant medications worldwide. However, over the past decade, their use during pregnancy, a period of extreme vulnerability to the onset of depression, has become highly concerning to patients and their healthcare providers in terms of safety to the developing fetus. Exposure to SSRIs in pregnancy has been associated with miscarriage, premature delivery, neonatal complications, birth defects-specifically cardiac defects-and, more recently, neurodevelopmental disorders in childhood, specifically autism spectrum disorders...
June 2016: CNS Drugs
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