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https://www.readbyqxmd.com/read/28917161/maternal-ssri-exposure-increases-the-risk-of-autistic-offspring-a-meta-analysis-and-systematic-review
#1
S Andalib, M R Emamhadi, S Yousefzadeh-Chabok, S K Shakouri, P F Høilund-Carlsen, M S Vafaee, T M Michel
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used to preclude maternal pregnancy depression. There is a growing body of literature assessing the association of prenatal exposure to SSRIs with autism spectrum disorder (ASD). The present systematic review and meta-analysis reviewed the medical literature and pooled the results of the association of prenatal exposure to SSRIs with ASD. METHODS: Published investigations in English by June 2016 with keywords of selective serotonin reuptake inhibitors, SSRI, autism spectrum disorder, ASD, pregnancy, childhood, children, neurodevelopment were identified using databases PubMed and PMC, MEDLINE, EMBASE, SCOPUS, and Google Scholar...
June 20, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28914073/problems-managed-and-medications-prescribed-during-encounters-with-people-with-autism-spectrum-disorder-in-australian-general-practice
#2
Rachael C Birch, Kitty-Rose Foley, Allan Pollack, Helena Britt, Nicholas Lennox, Julian N Trollor
Autism spectrum disorder is associated with high rates of co-occurring health conditions. While elevated prescription rates of psychotropic medications have been reported in the United Kingdom and the United States, there is a paucity of research investigating clinical and prescribing practices in Australia. This study describes the problems managed and medications prescribed by general practitioners in Australia during encounters where an autism spectrum disorder was recorded. Information was collected from 2000 to 2014 as part of the Bettering the Evaluation and Care of Health programme...
September 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28887608/erratum-to-interactive-effects-of-prenatal-antidepressant-exposure-and-likely-gene-disrupting-mutations-on-the-severity-of-autism-spectrum-disorder
#3
Sean Ackerman, Sarah Schoenbrun, Caitlin Hudac, Raphael Bernier
No abstract text is available yet for this article.
September 8, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28875615/prescription-trends-of-psychotropics-in-children-and-adolescents-with-autism-based-on-nationwide-health-insurance-data
#4
Minha Hong, Seung Yup Lee, Juhee Han, Jin Cheol Park, Yeon Jung Lee, Ram Hwangbo, Hyejung Chang, Seong Woo Cho, Soo Young Bhang, Bongseog Kim, Jun Won Hwang, Geon Ho Bahn
Children with autism are often medicated to manage emotional and behavioral symptoms; yet, data on such pharmacotherapy is insufficient. In this study, we investigated the Korean National Health Insurance Claims Database (NHICD) information related to autism incidence and psychotropic medication use. From the 2010-2012 NHICD, we selected a total of 31,919,732 subjects under 19 years old. To examine the diagnostic incidence, we selected patients who had at least one medical claim containing an 10th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-10) code for pervasive developmental disorder, F84, not diagnosed in the previous 360 days...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28812501/taking-antidepressants-during-pregnancy-linked-to-autism
#5
(no author information available yet)
Children exposed to antidepressants in utero are at a slightly higher risk of autism than children of mothers with psychiatric disorders who were not treated with antidepressants, a study has found.
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28810018/prenatal-antidepressant-use-and-autism-spectrum-disorder-reply
#6
LETTER
Simone N Vigod, Tara Gomes, Joel G Ray
No abstract text is available yet for this article.
August 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28810014/prenatal-antidepressant-use-and-autism-spectrum-disorder
#7
LETTER
Deepa Singal, Dan Chateau, Marni Brownell
No abstract text is available yet for this article.
August 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28770524/interactive-effects-of-prenatal-antidepressant-exposure-and-likely-gene-disrupting-mutations-on-the-severity-of-autism-spectrum-disorder
#8
Sean Ackerman, Sarah Schoenrbun, Caitlin Hudac, Raphael Bernier
To examine the interactive effects of two proposed risk factors which may contribute to symptom severity of Autism Spectrum Disorder (ASD): prenatal antidepressant exposure and likely gene-disrupting (LGD) mutations. Participants included 2748 individuals with ASD from the Simons Simplex Collection. We examined the effects of prenatal antidepressant exposure, maternal depression, presence of an LGD mutation and their interaction on ASD severity. We found a significant interactive effect between antidepressant exposure and the presence of an LGD mutation on ASD severity in the ADOS and ADI-R verbal communication domains...
August 2, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28724519/antidepressants-during-pregnancy-and-autism-in-offspring-population-based-cohort-study
#9
Dheeraj Rai, Brian K Lee, Christina Dalman, Craig Newschaffer, Glyn Lewis, Cecilia Magnusson
Objectives To study the association between maternal use of antidepressants during pregnancy and autism spectrum disorder (ASD) in offspring.Design Observational prospective cohort study with regression methods, propensity score matching, sibling controls, and negative control comparison.Setting Stockholm County, Sweden.Participants 254 610 individuals aged 4-17, including 5378 with autism, living in Stockholm County in 2001-11 who were born to mothers who did not take antidepressants and did not have any psychiatric disorder, mothers who took antidepressants during pregnancy, or mothers with psychiatric disorders who did not take antidepressants during pregnancy...
July 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28724517/prenatal-antidepressant-use-and-risk-of-autism
#10
EDITORIAL
Diana E Schendel
No abstract text is available yet for this article.
July 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28702506/prenatal-depression-risk-factors-developmental-effects-and-interventions-a-review
#11
Tiffany Field
This narrative review based on a literature search in PubMed and PsycInfo on the two terms prenatal and antenatal depression includes empirical studies, reviews and meta-analyses that have been published during the last 5 years on risk factors, developmental effects and interventions for prenatal depression. Risk factor studies that met criteria feature demographic measures (lower socioeconomic status, less education, non-marital status, non-employment, less social support and health locus of control, unintended pregnancy, partner violence and history of child abuse) and physiological variables (cortisol, amylase, and pro-inflammatory cytokines and intrauterine artery resistance)...
February 2017: Journal of Pregnancy and Child Health
https://www.readbyqxmd.com/read/28655626/differential-effects-of-perinatal-exposure-to-antidepressants-on-learning-and-memory-acoustic-startle-anxiety-and-open-field-activity-in-sprague-dawley-rats
#12
Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhees
Most antidepressants inhibit monoamine reuptake. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) act on the 5-HT transporter (SERT) whereas norepinephrine-dopamine reuptake inhibitors (NDRIs) act on the norepinephrine and dopamine transporters. Epidemiological reports link SSRI use during pregnancy to an increased prevalence of autism spectrum disorder (ASD). We previously showed that perinatal exposure to the SSRI citalopram (CIT) results in rodent offspring that exhibit a number of behaviors consistent with an ASD-like phenotype...
October 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28538871/what-do-cochrane-systematic-reviews-say-about-interventions-for-autism-spectrum-disorders
#13
Larissa Lyra, Luiz Eduardo Rizzo, Camila Sá Sunahara, Daniela Vianna Pachito, Carolina de Oliveira Cruz Latorraca, Ana Luiza Cabrera Martimbianco, Rachel Riera
CONTEXT AND OBJECTIVE: Autism spectrum disorders (ASDs) include autistic disorder, Asperger's disorder and pervasive developmental disorder. The manifestations of ASDs can have an important impact on learning and social functioning that may persist during adulthood. The aim here was to summarize the evidence from Cochrane systematic reviews on interventions for ASDs. DESIGN AND SETTING: Review of systematic reviews, conducted within the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo...
March 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28528584/autism-risk-following-antidepressant-medication-during-pregnancy
#14
A Viktorin, R Uher, A Reichenberg, S Z Levine, S Sandin
BACKGROUND: Previous studies have examined if maternal antidepressant medication during pregnancy increase the risk of autism spectrum disorder (ASD) in the offspring, but the results have been conflicting. METHODS: In a population-based cohort of 179 007 children born in 2006 and 2007 and followed through 2014 when aged 7 and 8, we estimated relative risks (RRs) of ASD and 95% confidence intervals (CIs) from Cox regression in children exposed to any antidepressant medication during pregnancy, and nine specific antidepressant drugs...
May 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28425298/understanding-self-reported-difficulties-in-decision-making-by-people-with-autism-spectrum-disorders
#15
Lydia Vella, Howard A Ring, Mike Rf Aitken, Peter C Watson, Alexander Presland, Isabel Ch Clare
Autobiographical accounts and a limited research literature suggest that adults with autism spectrum disorders can experience difficulties with decision-making. We examined whether some of the difficulties they describe correspond to quantifiable differences in decision-making when compared to adults in the general population. The participants (38 intellectually able adults with autism spectrum disorders and 40 neurotypical adults) were assessed on three tasks of decision-making (Iowa Gambling Task, Cambridge Gamble Task and Information Sampling Task), which quantified, respectively, decision-making performance and relative attention to negative and positive outcomes, speed and flexibility, and information sampling...
April 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28424150/antidepressants-in-pregnancy-are-not-associated-with-autism-risk-new-study-finds
#16
Ingrid Torjesen
No abstract text is available yet for this article.
April 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28418571/risk-for-autism-spectrum-disorders-according-to-period-of-prenatal-antidepressant-exposure-a-systematic-review-and-meta-analysis
#17
REVIEW
Antonia Mezzacappa, Pierre-Alexandre Lasica, Francesco Gianfagna, Odile Cazas, Patrick Hardy, Bruno Falissard, Anne-Laure Sutter-Dallay, Florence Gressier
Importance: Several studies have examined the links between prenatal exposure to antidepressants and autism spectrum disorders (ASDs) in children, with inconsistent results, especially regarding the impact of the trimester of exposure. Objective: To perform a systematic review of the literature and a meta-analysis of published studies to assess the association between ASDs and fetal exposure to antidepressants during pregnancy for each trimester of pregnancy and preconception...
June 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28418480/association-between-serotonergic-antidepressant-use-during-pregnancy-and-autism-spectrum-disorder-in-children
#18
Hilary K Brown, Joel G Ray, Andrew S Wilton, Yona Lunsky, Tara Gomes, Simone N Vigod
Importance: Previous observations of a higher risk of child autism spectrum disorder with serotonergic antidepressant exposure during pregnancy may have been confounded. Objective: To evaluate the association between serotonergic antidepressant exposure during pregnancy and child autism spectrum disorder. Design, Setting, and Participants: Retrospective cohort study. Health administrative data sets were used to study children born to mothers who were receiving public prescription drug coverage during pregnancy in Ontario, Canada, from 2002-2010, reflecting 4...
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28418479/associations-of-maternal-antidepressant-use-during-the-first-trimester-of-pregnancy-with-preterm-birth-small-for-gestational-age-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder-in-offspring
#19
Ayesha C Sujan, Martin E Rickert, A Sara Öberg, Patrick D Quinn, Sonia Hernández-Díaz, Catarina Almqvist, Paul Lichtenstein, Henrik Larsson, Brian M D'Onofrio
Importance: Prenatal antidepressant exposure has been associated with adverse outcomes. Previous studies, however, may not have adequately accounted for confounding. Objective: To evaluate alternative hypotheses for associations between first-trimester antidepressant exposure and birth and neurodevelopmental problems. Design, Setting, and Participants: This retrospective cohort study included Swedish offspring born between 1996 and 2012 and followed up through 2013 or censored by death or emigration...
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28418464/disentangling-maternal-depression-and-antidepressant-use-during-pregnancy-as-risks-for-autism-in-children
#20
EDITORIAL
Tim F Oberlander, Lonnie Zwaigenbaum
No abstract text is available yet for this article.
April 18, 2017: JAMA: the Journal of the American Medical Association
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