Wendy A Keitel, James D Campbell, John J Treanor, Emmanuel B Walter, Shital M Patel, Fenhua He, Diana L Noah, Heather Hill
BACKGROUND: Dose-sparing strategies are being explored for vaccines against pandemic influenza. We evaluated the dose-sparing potential of aluminum hydroxide (AlOH) adjuvant. METHODS: A total of 600 healthy subjects (age, 18-49 years) were randomized to receive 2 vaccinations 1 month apart with subvirion inactivated influenza A/H5N1 vaccine containing 7.5, 15, or 45 microg of hemagglutinin (HA), with or without 600 microg of aluminum hydroxide (AlOH), or 3.75 microg of HA, with or without 300 microg of AlOH...
November 1, 2008: Journal of Infectious Diseases