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https://www.readbyqxmd.com/read/29527185/intra-arterial-thrombolysis-for-acute-central-retinal-artery-occlusion-a-systematic-review-and-meta-analysis
#1
Paul S Page, Nicolas K Khattar, Andrew C White, Alexander C Cambon, Guy N Brock, Shesh N Rai, Robert F James
Background and purpose: Acute central retinal artery occlusion (CRAO) is a serious ophthalmologic emergency that may result in monocular blindness. To date, studies evaluating intra-arterial thrombolysis (IAT) have not shown a definitive clinical benefit. We have conducted a systematic review with a meta-analysis to effectively evaluate this treatment option. Methods: A systematic literature search was focused on studies containing five or more patients undergoing IAT that included a control group treated with standard therapy...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29477145/hemodynamic-effects-of-acute-hyperoxia-systematic-review-and-meta-analysis
#2
REVIEW
Bob Smit, Yvo M Smulders, Johannes C van der Wouden, Heleen M Oudemans-van Straaten, Angelique M E Spoelstra-de Man
BACKGROUND: In clinical practice, oxygen is generally administered to patients with the intention of increasing oxygen delivery. Supplemental oxygen may, however, cause arterial hyperoxia, which is associated with hemodynamic alterations. We performed a systematic review and meta-analysis of the literature to determine the effect of hyperoxia on central hemodynamics and oxygen delivery in healthy volunteers and cardiovascular-compromised patients. METHODS: PubMed and EMBASE were searched up to March 2017...
February 25, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29468203/inner-retinal-vasculopathy-in-zika-virus-disease
#3
Mandeep S Singh, Maria Carolina Marquezan, Revaz Omiadze, Ashvini K Reddy, Rubens Belfort, William N May
Purpose: Zika virus infection is associated with vision-threatening ocular complications including uveitis and outer retinopathy. The aim of this report is to describe a case of an adult patient with serologically confirmed Zika infection who presented with retinal vascular abnormalities that coincided with systemic post-viral neurological manifestations of the disease. Observations: A 34-year-old white female presented with symptoms of peripheral neuropathy following serologically confirmed Zika virus infection that was acquired in Puerto Rico four months prior to presentation...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29447915/comparing-treatment-of-acute-retinal-necrosis-with-either-oral-valaciclovir-or-intravenous-aciclovir
#4
Julijana Baltinas, Sue Lightman, Oren Tomkins-Netzer
PURPOSE: To compare the visual outcomes of patients with acute retinal necrosis (ARN) treated initially with intravenous aciclovir versus oral valaciclovir therapy. DESIGN: Retrospective, comparative, interventional case series. METHODS: 62 patients (68 eyes) with ARN, treated at Moorfields Eye Hospital (United Kingdom) between 1992 and 2016, were identified through the hospital's electronic database. Exclusion criteria included insufficient patient records or follow-up (<150 days)...
February 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29443808/retinal-microvasculature-alteration-in-paracentral-acute-middle-maculopathy-and-acute-macular-neuroretinopathy-a-quantitative-optical-coherence-tomography-angiography-study
#5
Alexei N Kulikov, Dmitrii S Maltsev, Tatiana A Leongardt
PURPOSE: To present a series of idiopathic paracentral acute middle maculopathy (PAMM) and acute macular neuroretinopathy (AMN) cases and to compare the microvascular retinal status of PAMM/AMN eyes with those of healthy individuals. METHODS: Six eyes with PAMM and two eyes with AMN in a total of six patients were included in this study. Multimodal retinal imaging, including optical coherence tomography angiography, was performed in all patients. The vessel density of the superficial capillary plexus and deep capillary plexus, as well as the area, circularity, and angle of the superficial foveal avascular zone (FAZ) were measured and compared with the same parameters in age-matched healthy individuals...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29384802/optimal-intereye-difference-thresholds-in-retinal-nerve-fiber-layer-thickness-for-predicting-a-unilateral-optic-nerve-lesion-in-multiple-sclerosis
#6
Rachel C Nolan, Steven L Galetta, Teresa C Frohman, Elliot M Frohman, Peter A Calabresi, Carmen Castrillo-Viguera, Diego Cadavid, Laura J Balcer
BACKGROUND: The optic nerve is a frequent site for involvement in multiple sclerosis (MS). Optical coherence tomography (OCT) detects thinning of the retinal nerve fiber layer (RNFL) in eyes of patients with MS and in those meeting criteria for clinically or radiologically isolated demyelinating syndromes. Current international diagnostic criteria for MS do not include the optic nerve as an imaging lesion site despite the high prevalence of acute optic neuritis (ON), or occult optic neuropathy, among early MS and clinically isolated syndrome patients; as well as most MS patients over the course of the disease...
January 29, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29374647/acute-retinal-detachment-induced-by-the-valsalva-manoeuvre-in-morning-glory-disc-anomaly
#7
Mark A P Fajgenbaum, Serafeim N Antonakis, Luke Membrey, David A Laidlaw
We present a case in which a large, bullous, predominantly inferior, serous retinal detachment developed acutely after the Valsalva manoeuvre (from a coughing fit) in an eye with morning glory disc anomaly. We postulate that a rapid alteration in intracranial pressure was transmitted through the cavitary disc defect. This allowed a sudden influx of cerebrospinal fluid and/or liquefied vitreous into the subretinal space. This previously unreported case provides important evidence for the role of intracranial pressure fluctuations in the pathogenesis of macular schisis and neurosensory detachment secondary to optic disc cavitations...
January 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29370018/differentiating-occult-branch-retinal-artery-occlusion-from-primary-open-angle-glaucoma
#8
Michael Sullivan-Mee, Pathik Amin, Denise Pensyl, Suchitra Katiyar
SIGNIFICANCE: Clinical findings in occult branch retinal artery occlusion (BRAO) can mimic those of primary open-angle glaucoma (POAG). Because management of these conditions substantially differs, accurate diagnosis is crucial. Our comparative analysis indicates that specific macular thickness variables reliably differentiate these conditions and that macular scanning may enhance routine glaucoma evaluation. PURPOSE: The aim of this study was to identify clinical factors that reliably and efficiently identify occult BRAO masquerading as POAG...
January 25, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29247551/occipital-blood-brain-barrier-permeability-is-an-independent-predictor-of-visual-outcome-in-type-2-diabetes-irrespective-of-the-retinal-barrier-a-longitudinal-study
#9
S I Abuhaiba, M Cordeiro, A Amorim, Â Cruz, B Quendera, C Ferreira, L Ribeiro, R Bernardes, M Castelo-Branco
Blood-brain barrier (BBB) permeability in type 2 diabetic patients has been previously shown to be altered in certain brain regions such as the basal ganglia and the hippocampus. Because of the histological and functional similarities between the BBB) and the blood-retinal barrier (BRB), we aimed to investigate how the permeability of both barriers predicts visual outcome. We included 2 control groups (acute unilateral stroke patients, n = 9; type 2 diabetics without BRB leakage n = 10) and a case study group of type 2 diabetics with established BRB leakage (n = 17)...
January 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29241762/eltrombopag-for-advanced-myelodysplastic-syndromes-or-acute-myeloid-leukaemia-and-severe-thrombocytopenia-aspire-a-randomised-placebo-controlled-phase-2-trial
#10
Moshe Mittelman, Uwe Platzbecker, Boris Afanasyev, Sebastian Grosicki, Raymond S M Wong, Achilles Anagnostopoulos, Benjamin Brenner, Claudio Denzlinger, Giuseppe Rossi, Arnon Nagler, Regina Garcia-Delgado, Maria Socorro O Portella, Zewen Zhu, Dominik Selleslag
BACKGROUND: Thrombocytopenia is a life-threatening complication in patients with advanced myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). In this study (ASPIRE), we aimed to assess eltrombopag, an oral thrombopoietin receptor agonist, for thrombocytopenia (grade 4) treatment in adult patients with advanced MDS or AML. METHODS: ASPIRE consisted of an open-label, double-blind phase for 8 weeks and a randomised, double-blind phase (parts 1 and 2, reported here) for 12 weeks, and an open-label extension (part 3)...
January 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29191218/analysis-of-choroidal-and-central-foveal-thicknesses-in-acute-anterior-uveitis-by-enhanced-depth-imaging-optical-coherence-tomography
#11
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
BACKGROUND: Currently, there are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU). The aim of this study was to evaluate choroidal and central foveal thicknesses during episodes of AAU. METHODS: The medical records of 120 patients with AAU and 120 healthy subjects matched for age, sex, and spherical equivalent of refractive error were reviewed. Subjects were divided into group 1 (AAU-affected eyes), 2 (unaffected fellow eyes), and 3 (healthy control eyes)...
December 1, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29146307/long-term-visual-outcomes-and-safety-profile-of-27-gauge-pars-plana-vitrectomy-for-posterior-segment-disease
#12
M Ali Khan, Alexander Kuley, Christopher D Riemann, Maria H Berrocal, Rohit R Lakhanpal, Jason Hsu, Arunan Sivalingam, Allen C Ho, Carl D Regillo
PURPOSE: To report longer-term outcomes of 27-gauge pars plana vitrectomy (PPV) in eyes with posterior segment disease. DESIGN: Multicenter, retrospective, interventional case series. PARTICIPANTS: A total of 390 eyes of 360 patients undergoing 27-gauge PPV for a vitreoretinal surgery indication. INTERVENTION: Three-port, transconjunctival, 27-gauge PPV. MAIN OUTCOME MEASURES: Change in visual acuity (VA) and occurrence of intraoperative and postoperative complications with a minimum follow-up of 365 days...
March 2018: Ophthalmology
https://www.readbyqxmd.com/read/29135604/chemical-burns-of-the-eye-the-role-of-retinal-injury-and-new-therapeutic-possibilities
#13
Claes H Dohlman, Fabiano Cade, Caio V Regatieri, Chengxin Zhou, Fengyang Lei, Alja Crnej, Mona Harissi-Dagher, Marie-Claude Robert, George N Papaliodis, Dongfeng Chen, James V Aquavella, Esen K Akpek, Anthony J Aldave, Kimberly C Sippel, Donald J DʼAmico, Jan G Dohlman, Per Fagerholm, Liqiang Wang, Lucy Q Shen, Miguel González-Andrades, James Chodosh, Kenneth R Kenyon, C Stephen Foster, Roberto Pineda, Samir Melki, Kathryn A Colby, Joseph B Ciolino, Demetrios G Vavvas, Shigeru Kinoshita, Reza Dana, Eleftherios I Paschalis
PURPOSE: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases. METHODS: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed. RESULTS: Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Long term outcomes, however, are hampered by early retinal damage causing glaucoma. New data suggest that rapid diffusion of inflammatory cytokines posteriorly (TNF-α, etc) can severely damage the ganglion cells...
February 2018: Cornea
https://www.readbyqxmd.com/read/29102785/melanopsin-expressing-retinal-ganglion-cells-are-relatively-resistant-to-excitotoxicity-induced-by-n-methyl-d-aspartate
#14
Songtao Wang, Dandan Gu, Peng Zhang, Jing Chen, Yan Li, Honglei Xiao, Guomin Zhou
Excitotoxicity plays an important role in neuronal loss in glaucoma. Previous studies indicate melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) are more injury-resistant. However, whether melanopsin-expressing ipRGCs are resistant to N-methyl-d-aspartate (NMDA) induced excitotoxicity is not well understood. In the present study, we investigated the effects of NMDA-induced excitotoxicity in conventional retinal ganglion cells (RGCs) and melanopsin-expressing ipRGCs in adult mice...
November 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29075764/the-effect-of-acutely-elevated-intraocular-pressure-on-the-functional-and-blood-flow-responses-of-the-rat-retina-to-flicker-stimulation
#15
Bingyao Tan, Benjamin MacLellan, Erik Mason, Kostadinka K Bizheva
Purpose: To evaluate the effect of acutely elevated intraocular pressure (IOP) on the functional and blood flow responses of the rat retina to flicker stimulation. Methods: Brown Norway (n = 15) rats were dark-adapted before ketamine/xylazine anesthesia. IOP was raised acutely in one eye to ∼45 mm Hg with a vascular loop. In 11 rats, white light flicker stimulus (10 Hz, 2 seconds duration, 0.80 log scotopic cd·s/m2) was applied before and during IOP elevation, and 10 minutes after loop removal...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29057162/augmenting-endogenous-levels-of-retinal-annexin-a1-suppresses-uveitis-in-mice
#16
Peter J Gardner, Samia Yazid, Joana Ribeiro, Robin R Ali, Andrew D Dick
PURPOSE: The purpose of this study was to examine the expression of the anti-inflammatory protein Annexin A1 (AnxA1) in mice and human retinae during uveitis and to determine whether local administration of human recombinant AnxA1 (hrAnxA1) can suppress uveitis in mice. METHODS: Retinal sections from mice (healthy normal and uveitis) and postmortem human (no history of eye disease ( n = 5) and uveitis ( n = 7)) were stained for AnxA1 expression and imaged by immunofluorescence microscopy...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29029471/protective-effect-of-resveratrol-against-light-induced-retinal-degeneration-in-aged-samp8-mice
#17
Zhirong Liu, Zhengzheng Wu, Jie Li, Anna Marmalidou, Ruifan Zhang, Man Yu
PURPOSE: The purpose of this study was to determine the protective effects of Resveratrol (RESV) on acute bright light-induced retinal degeneration in aged senescence accelerated mouse strain. METHODS: Ten three-month-old male SAMP8 mice (prone to aging) were randomly assigned to two experimental dietary groups: one untreated group and one RESV treatment group (n=20 eyes for each group). After 30 days of treatment, mice were exposed to intense bright light. Ten male SAMR1 mice (resistant to aging) served as control (n=20 eyes)...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027919/shiga-toxins-induce-apoptosis-and-er-stress-in-human-retinal-pigment-epithelial-cells
#18
Jun-Young Park, Yu-Jin Jeong, Sung-Kyun Park, Sung-Jin Yoon, Song Choi, Dae Gwin Jeong, Su Wol Chung, Byung Joo Lee, Jeong Hun Kim, Vernon L Tesh, Moo-Seung Lee, Young-Jun Park
Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae serotype 1 and select serotypes of Escherichia coli are the most potent known virulence factors in the pathogenesis of hemorrhagic colitis progressing to potentially fatal systemic complications such as acute renal failure, blindness and neurological abnormalities. Although numerous studies have defined apoptotic responses to Shiga toxin type 1 (Stx1) or Shiga toxin type 2 (Stx2) in a variety of cell types, the potential significance of Stx-induced apoptosis of photoreceptor and pigmented cells of the eye following intoxication is unknown...
October 13, 2017: Toxins
https://www.readbyqxmd.com/read/29025171/-the-impact-of-macular-development-on-full-field-and-multifocal-erg-in-extremely-preterm-born-children-with-and-without-acute-retinopathy-of-prematurity
#19
Wadim Bowl, Silke Schweinfurth, Kerstin Holve, Knut Stieger, Birgit Lorenz, Monika Andrassi-Darida
Introduction Retinal development is a complex process that can continue into early childhood and beyond. Prematurity can affect the maturation of the central retina, characterised by a flatter foveal pit and overlying inner retinal layers (IRL), leading to a disturbed ratio of outer retinal layers to IRL ("macular developmental arrest": MDA) and functional impairment (Bowl et al. 2016 18). The purpose of this study was to correlate functional results by electrophysiology with the morphological appearance of the fovea in children with spontaneously regressed and without ROP and term-born age-matched controls...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28994605/explicit-diagnostic-criteria-for-transient-ischemic-attacks-to-differentiate-it-from-migraine-with-aura
#20
Elena R Lebedeva, Natalia M Gurary, Denis V Gilev, Anne Francke Christensen, Jes Olesen
Background The diagnosis of transient ischemic attacks is fraught with problems. The inter-observer agreement has repeatedly been shown to be low even in a neurological setting, and the specificity of the diagnosis is modest to low, reflected in a poor separation of transient ischemic attacks and mimics, particularly migraine with aura with its varied symptomatology. In other disease areas, explicit diagnostic criteria have improved sensitivity and specificity of diagnoses. We therefore present novel explicit diagnostic criteria for transient ischemic attacks tested for sensitivity and for specificity against migraine with aura...
January 1, 2017: Cephalalgia: An International Journal of Headache
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