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https://www.readbyqxmd.com/read/29500513/existence-and-stability-of-periodic-solutions-of-an-impulsive-differential-equation-and-application-to-cd8-t-cell-differentiation
#1
Simon Girel, Fabien Crauste
Unequal partitioning of the molecular content at cell division has been shown to be a source of heterogeneity in a cell population. We propose to model this phenomenon with the help of a scalar, nonlinear impulsive differential equation (IDE). To study the effect of molecular partitioning at cell division on the effector/memory cell-fate decision in a CD8 T-cell lineage, we study an IDE describing the concentration of the protein Tbet in a CD8 T-cell, where impulses are associated to cell division. We discuss how the degree of asymmetry of molecular partitioning can affect the process of cell differentiation and the phenotypical heterogeneity of a cell population...
March 2, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29493223/ratiometric-near-infrared-fluorescent-probes-based-on-tbet-and-%C3%AF-conjugation-modulation-between-tetraphenylethene-and-hemicyanine-moieties-for-sensitive-detection-of-ph-changes-in-live-cells
#2
Haiying Liu, Jianbo Wang, Shuai Xia, Jianheng Bi, Mingxi Fang, Wafa Mazi, Yibin Zhang, Nathan Conner, Fen-Tair Luo, H Peter Lu
In the paper, we present three ratiometric near-infrared fluorescent probes (A-C) for accurate ratiometric detection of intracellular pH changes in live cells. Probe A consists of tetraphenylethene (TPE) donor and near-infrared hemicyanine acceptor in a through-bond energy transfer (TBET) strategy while probes B and C are composed of TPE and hemicyanine moieties through a single and double sp2 carbon-carbon bond connections in a π-conjugation modulation strategy. The specific targeting of the probes to lysosomes in live cells was achieved by introducing morpholine residues to the hemicyanine moieties to form closed spirolactam ring structures...
March 1, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29484182/regulatory-t-cells-in-renal-disease
#3
REVIEW
Maliha A Alikhan, Megan Huynh, A Richard Kitching, Joshua D Ooi
The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic insults, all of which at least to some degree involve inflammation. Regulatory T cells modulate systemic autoimmune and allogenic responses in glomerulonephritis and transplantation. Intrarenal regulatory T cells (Tregs), including those recruited to the kidney, have suppressive effects on both adaptive and innate immune cells, and probably also intrinsic kidney cells. Evidence from autoimmune glomerulonephritis implicates antigen-specific Tregs in HLA-mediated dominant protection, while in several human renal diseases Tregs are abnormal in number or phenotype...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29445199/lack-of-t-bet-reduces-monocytic-interleukin-12-formation-and-accelerates-thrombus-resolution-in-deep-vein-thrombosis
#4
Tanja Schönfelder, Moritz Brandt, Sabine Kossmann, Tanja Knopp, Thomas Münzel, Ulrich Walter, Susanne H Karbach, Philip Wenzel
The role of leukocytes in deep vein thrombosis (DVT) resolution is incompletely understood. We determined how depletion of lysozyme positive (LysM + ) cells and a switched-off type 1 immune response influences thrombus resolution. DVT was induced in 12-week-old male mice by inferior vena cava (IVC) stenosis. Toxin mediated depletion of myeloid cells improved thrombus resolution in mice with Cre-inducible expression of the diphtheria toxin receptor in LysM + cells. This correlated with decreased CD45 + cells, a population shift of Gr-1 + to Gr-1 - CD11b + myelomonocytic cells (flow cytometry) and an increase in CC-chemokine ligand 2, interleukin-4 and interleukin-10 mRNA expressions...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29431990/bioorthogonally-applicable-fluorogenic-cyanine-tetrazines-for-no-wash-super-resolution-imaging
#5
Gergely Knorr, Eszter Kozma, Judith Schaart, Krisztina Németh, György Török, Peter Kele
The synthesis, fluorogenic characterization and labeling application of four tetrazine-quenched cyanine probes with emission maxima in the red - far red range is reported. Fluorescence of the cyanine-cores is quenched via through-bond-energy-transfer (TBET) exerted by a bioorthogonal tetrazine unit. Upon bioorthogonal labeling reaction with cyclooctyne tagged proteins, the quenching effect ceases, thus the fluorescence reinstates, resulting in an increase in fluorescence intensity. As a rare example amongst indocyanines, one of our new probes was found suitable in STED-based super-resolution imaging...
February 12, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29409726/intranuclear-delivery-of-the-transcription-modulation-domain-of-tbet-improved-lupus-nephritis-in-nzb-nzw-f1-lupus-prone-mice
#6
Jae-Seung Moon, Chin Hee Mun, Jung-Ho Kim, Jen-Young Cho, Sung-Dong Park, Tae-Yoon Park, Jin-Su Shin, Chun-Chang Ho, Yong-Beom Park, Sankar Ghosh, Alfred L M Bothwell, Sang-Won Lee, Sang-Kyou Lee
Excessive expression of Tbet and IFNγ is evidence of systemic lupus erythematosus (SLE) in lupus patients. In this study, the nucleus-transducible form of Transcription Modulation Domain (TMD) of Tbet (ntTbet-TMD), which is a fusion protein between Protein Transduction Domain Hph-1 (Hph-1-PTD) and the TMD of Tbet comprising DNA binding domain and isotype-specific domain, was generated to inhibit Tbet-mediated transcription in the interactomic manner. ntTbet-TMD was effectively delivered into the nucleus of the cells and specifically inhibited Tbet-mediated transcription without influencing the differentiation of other T cell subsets and signaling events for T cell activation...
February 3, 2018: Kidney International
https://www.readbyqxmd.com/read/29334084/a-cyanine-based-fluorescent-cassette-with-aggregation-induced-emission-for-sensitive-detection-of-ph-changes-in-live-cells
#7
Mingxi Fang, Shuai Xia, Jianheng Bi, Travis P Wigstrom, Loredana Valenzano, Jianbo Wang, Wafa Mazi, Marina Tanasova, Fen-Tair Luo, Haiying Liu
An aggregation-induced emission (AIE) cyanine-based fluorescent cassette with a large pseudo-Stokes shift was designed and prepared to sensitively image pH changes in live cells via through-bond energy transfer (TBET) from a tetraphenylethene (TPE) donor to a cyanine acceptor.
January 25, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29311382/tissue-resident-cytolytic-innate-lymphocytes-in-cancer
#8
REVIEW
Briana G Nixon, Ming O Li
Innate lymphoid cells (ILCs) are critical components of tissues in the body, providing a first line of defense against challenges to host integrity. In contrast to strictly cytokine-producing helper ILCs, resident innate lymphocyte populations with cytolytic potential have been identified in multiple tissues in both mouse and human. These cells express the transcription factor Tbet, NK cell receptors, granzymes, perforin, and death receptors, and can directly kill tumor cells. Signals in the tumor microenvironment may promote this response, including the cytokine IL-15 and stress-associated ligands for activating NK receptors...
January 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29296775/th17-immune-microenvironment-in-epstein-barr-virus-negative-hodgkin-lymphoma-implications-for-immunotherapy
#9
Amy S Duffield, Maria Libera Ascierto, Robert A Anders, Janis M Taube, Alan K Meeker, Shuming Chen, Tracee L McMiller, Neil A Phillips, Haiying Xu, Aleksandra Ogurtsova, Alan E Berger, Drew M Pardoll, Suzanne L Topalian, Richard F Ambinder
Classical Hodgkin lymphoma (CHL) is a neoplasm characterized by robust inflammatory infiltrates and heightened expression of the immunosuppressive PD-1/PD-L1 pathway. Although anti-PD-1 therapy can be effective in >60% of patients with refractory CHL, improved treatment options are needed for CHLs which are resistant to anti-PD-1 or relapse after this form of immunotherapy. A deeper understanding of immunologic factors in the CHL microenvironment might support the design of more effective treatment combinations based on anti-PD-1...
July 25, 2017: Blood Advances
https://www.readbyqxmd.com/read/29224845/expanding-roles-for-the-tbet-b-cell-subset-in-health-and-disease
#10
EDITORIAL
Michael P Cancro
No abstract text is available yet for this article.
November 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29211057/neonatal-neutrophils-stimulated-by-group-b-streptococcus-induce-a-proinflammatory-t-helper-cell-bias
#11
Jianguo Lin, Seema Haridas, Stephen J Barenkamp, Larissa Chioquetta Lorenset, Ashley Sang Eun Lee, Benjamin T Schroeder, Guangyong Peng, Joyce M Koenig
BackgroundGroup B Streptococcus (GBS) infection causes inflammatory comorbidities in newborns. While the mechanisms remain unclear, evidence suggests that impaired innate-adaptive immune interactions may be contributory. We hypothesized that GBS-stimulated neonatal neutrophils provide a milieu that may drive proinflammatory T-helper (Th) cell programming.MethodsNeutrophils were stimulated with Type III GBS (COH1); supernatants or intact neutrophils were cocultured with CD4+ T cells or regulatory T cells (Tregs)...
December 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29143979/analysis-of-anti-tnf-induced-skin-lesions-reveals-strong-th1-activation-with-some-distinct-immunological-characteristics
#12
E Stoffel, H Maier, E Riedl, M-C Brüggen, B Reininger, M Schaschinger, C Bangert, E Guenova, G Stingl, P M Brunner
BACKGROUND: Psoriasiform and eczematous eruptions are the most common dermatological adverse reaction linked to anti-TNF-α therapy. Yet, a detailed characterization of their immune phenotype is lacking. OBJECTIVES: We sought to characterize anti-TNF-α induced inflammatory skin lesions on a histopathologic, cellular and molecular level, compared to psoriasis, eczema (atopic dermatitis), and healthy control skin. METHODS: Histopathologic evaluation, gene expression (quantitative RT-PCR) and computer-assisted immunohistologic studies (TissueFAXS) were performed on 19 skin biopsies from IBD (n=17) and rheumatoid arthritis (n=2) patients with new-onset inflammatory skin lesions during anti-TNF-α-therapy...
November 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29140452/mechanical-ventilation-induces-il-4-secretion-in-lungs-and-reduces-the-phagocytic-capacity-of-lung-macrophages
#13
Kenny Bielen, Bart 's Jongers, Jan Boddaert, Christine Lammens, Philippe G Jorens, Surbhi Malhotra-Kumar, Herman Goossens, Samir Kumar-Singh
Patients receiving mechanical ventilation are at risk of developing ventilator-associated pneumonia. Here, we show that clinically utilized ventilation protocols in rat with 5 or 8 mL/kg tidal volumes cause increased IL-4 expression, lowered ratio of TH1:TH2 transcriptional factors (Tbet:Gata3) and increased arginase1-positive (Arg1+) macrophages and eosinophils in lungs. Macrophages from ventilated lungs had reduced ex vivo capacity towards phagocytosing bacteria. Ventilated animals, when further challenged with bacterial pneumonia, continued to show persistence of Arg1+ M2 macrophages as well as an increased bacterial burden compared to spontaneously breathing animals receiving the same bacterial dose...
November 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29123515/dietary-intervention-with-%C3%AE-lactoglobulin-derived-peptides-and-a-specific-mixture-of-fructo-oligosaccharides-and-bifidobacterium-breve-m-16v-facilitates-the-prevention-of-whey-induced-allergy-in-mice-by-supporting-a-tolerance-prone-immune-environment
#14
Atanaska I Kostadinova, Alba Pablos-Tanarro, Mara A P Diks, Betty C A M van Esch, Johan Garssen, Léon M J Knippels, Linette E M Willemsen
Cow's milk allergy (CMA) prevails in infants and brings increased risk of developing other allergic diseases. Oral administration of specific β-lactoglobulin (BLG)-derived peptides (PepMix) and a specific blend of short- and long-chain fructo-oligosaccharides and Bifidobacterium breve M-16V (FF/ Bb ) was found to partially prevent CMA development in mice. In this study, we aimed to expand the knowledge on the preventive potential and the underlying mechanisms of this approach. Three-week-old female C3H/HeOuJ mice were orally exposed to PepMix±FF/ Bb prior to a 5-week oral sensitization with whole whey and cholera toxin as an adjuvant...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29115050/localization-of-the-t-cell-response-to-rsv-infection-is-altered-in-infant-mice
#15
Katherine M Eichinger, Jessica L Kosanovich, Kerry M Empey
OBJECTIVES: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections worldwide, causing disproportionate morbidity and mortality in infants and children. Infants with stronger Th1 responses have less severe disease, yet little is known about the infant T-cell response within the air space. Thus, we tested the hypothesis that RSV infected infant mice would have quantitative and qualitative deficiencies in CD4+ and CD8+ T-cell populations isolated from the bronchoalveolar lavage when compared to adults and that local delivery of IFN-γ would increase airway CD4+ Tbet+ and CD8+ Tbet+ T-cell responses...
February 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29047166/pre-assembled-coumarin-rhodamine-scaffold-for-ratiometric-sensing-of-nitric-oxide-and-hypochlorite
#16
Jun Xiang Ong, Victoria Yu Ting Pang, Li Min Tng, Wee Han Ang
A new pre-assembled ratiometric sensing platform was constructed from a coumarin donor and a rhodamine acceptor designed for through-bond energy transfer (TBET). A phenylacetylene linker was installed to disrupt the planarity of the extended conjugated system but retaining the efficient energy transfer between the donor and acceptor motifs. To demonstrate its versatility as a sensing platform, we conjugated recognition motifs through amide coupling reactions to yield two TBET chemosensors capable of sensing either endogenously produced NO and ClO- ...
February 6, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28973925/foxo1-opposition-of-cd8-t-cell-effector-programming-confers-early-memory-properties-and-phenotypic-diversity
#17
Arnaud Delpoux, Chen-Yen Lai, Stephen M Hedrick, Andrew L Doedens
The factors and steps controlling postinfection CD8(+) T cell terminal effector versus memory differentiation are incompletely understood. Whereas we found that naive TCF7 (alias "Tcf-1") expression is FOXO1 independent, early postinfection we report bimodal, FOXO1-dependent expression of the memory-essential transcription factor TCF7 in pathogen-specific CD8(+) T cells. We determined the early postinfection TCF7(high) population is marked by low TIM3 expression and bears memory signature hallmarks before the appearance of established memory precursor marker CD127 (IL-7R)...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28945272/cd4-t-helper-cells-and-regulatory-t-cells-in-active-lupus-nephritis-an-imbalance-towards-a-predominant-th1-response
#18
D Mesquita, G Mastroianni Kirsztajn, M F Franco, L A Reis, S F Perazzio, F V Mesquita, V da Silva Ferreira, L E Coelho Andrade, A W Silva de Souza
The objective of this study was to evaluate the frequency of CD4+ T cell subsets in peripheral blood mononuclear cells (PBMC), urine and renal tissue from patients with lupus nephritis (LN). PBMC and urinary cells were collected from 17 patients with active LN, 20 disease controls (DC) with primary glomerulonephritis and 10 healthy controls (HC) and were analysed by flow cytometry with markers for T helper type 1 (Th1), Th2, Th17 and regulatory T cells (Treg ) cells. T cell subsets were assessed by immunohistochemistry from LN biopsy specimens from 12 LN patients...
January 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28882699/neutrophil-infiltration-is-a-favorable-prognostic-factor-in-early-stages-of-colon-cancer
#19
Maria L Wikberg, Agnes Ling, Xingru Li, Åke Öberg, Sofia Edin, Richard Palmqvist
The tumor immune response has been proven critical to prognosis in colorectal cancer (CRC), but studies on the prognostic role of neutrophil infiltration have shown contradictory results. The aim of this study was to elucidate the prognostic role of infiltrating neutrophils at different intratumoral subsites and in different molecular subgroups of CRC. The relations between neutrophil infiltration and infiltration of other immune cells (T-cell and macrophage subsets) were also addressed. Expression of the neutrophil marker CD66b was assessed by immunohistochemistry in 448 archival human tumor tissue samples from patients surgically resected for CRC...
October 2017: Human Pathology
https://www.readbyqxmd.com/read/28833201/dynamics-of-regulatory-t-cells-t-regs-in-patients-with-oral-squamous-cell-carcinoma
#20
Sadhna Aggarwal, Suresh C Sharma, Satya N Das
BACKGROUND AND OBJECTIVES: The immune dysfunction in oral squamous cell carcinoma (OSCC) patients is one of the major factors for growth and dissemination of tumor affecting disease-free survival. METHODS: The phenotypic and functional characteristics of Regulatory T (Treg ) CD4+ CD25+ FoxP3+ subsets in OSCC patients were assessed by multicolor flow cytometry and its effector component (TGF-β) by Western blot and qRT-PCR. RESULTS: An increased (P < 0...
December 2017: Journal of Surgical Oncology
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