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https://www.readbyqxmd.com/read/27866814/predictors-of-tissue-healing-in-ulcerative-colitis-patients-treated-with-anti-tnf
#1
Nikos Viazis, Marios Giakoumis, Giorgos Bamias, Dimitris Goukos, Theodoros Koukouratos, Konstantina Katopodi, Pantelis Karatzas, Christos Triantos, Chrisostomos Tsolias, Georgios Theocharis, George L Daikos, Spyros D Ladas, Dimitrios G Karamanolis, Gerasimos J Mantzaris
AIM: To identify factors predicting mucosal healing in ulcerative colitis patients treated with anti-TNFα agents with or without azathioprine. METHODS: In a prospective, multicenter, one-year study biologic naïve patients aged 25-65 years, with corticosteroid-dependent or refractory colitis received combination treatment with anti-TNFα and azathioprine for 6 months followed by anti-TNFα monotherapy. Patients who denied combination therapy or were outside this age range received anti-TNFα monotherapy (controls)...
October 20, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27814345/pro-inflammatory-immune-responses-in-leukocytes-of-premature-infants-exposed-to-maternal-chorioamnionitis-or-funisitis
#2
Courtney M Jackson, Casey B Wells, Meredith E Tabangin, Jareen Meinzen-Derr, Alan H Jobe, Claire A Chougnet
BACKGROUND: Acute chorioamnionitis contributes to premature birth, and is associated with post-birth complications. How chorioamnionitis impacts neonate's developing immune system has not been well defined. METHODS: Blood from extremely preterm infants (=28 weeks gestation) was drawn at the 1(st), 2(nd), and 4(th) week of life. Blood was either left unstimulated or stimulated for 4 hours with PMA/ionomycin. mRNA expression of transcription factors in unstimulated cells (RORC, TBET, GATA3, FOXP3) and inflammatory cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-5, and IL-6) in unstimulated and stimulated cells were analyzed...
November 4, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27793998/mapping-the-fetomaternal-peripheral-immune-system-at-term-pregnancy
#3
Gabriela K Fragiadakis, Quentin J Baca, Pier Federico Gherardini, Edward A Ganio, Dyani K Gaudilliere, Martha Tingle, Hope L Lancero, Leslie S McNeil, Matthew H Spitzer, Ronald J Wong, Gary M Shaw, Gary L Darmstadt, Karl G Sylvester, Virginia D Winn, Brendan Carvalho, David B Lewis, David K Stevenson, Garry P Nolan, Nima Aghaeepour, Martin S Angst, Brice L Gaudilliere
Preterm labor and infections are the leading causes of neonatal deaths worldwide. During pregnancy, immunological cross talk between the mother and her fetus is critical for the maintenance of pregnancy and the delivery of an immunocompetent neonate. A precise understanding of healthy fetomaternal immunity is the important first step to identifying dysregulated immune mechanisms driving adverse maternal or neonatal outcomes. This study combined single-cell mass cytometry of paired peripheral and umbilical cord blood samples from mothers and their neonates with a graphical approach developed for the visualization of high-dimensional data to provide a high-resolution reference map of the cellular composition and functional organization of the healthy fetal and maternal immune systems at birth...
December 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27793666/characterization-of-%C3%AE-%C3%AE-regulatory-t-cells-from-peripheral-blood-in-patients-with-multiple-myeloma
#4
M A Yongyong, Huyi Lei, Jie Tan, Xuan Li, Xiuli Wu, Qifa Liu
γδ regulatory T cells are able to inhibit the activation and function of T cells involved in antigen-specific immune responses. This study aimed to investigate the potential role of γδ regulatory T cells in inhibiting anti-tumor immune responses in patients diagnosed as multiple myeloma (MM). We measured the levels of γδ T cells, the distribution and clonally amplified TCR Vγ and VδT cells in peripheral blood of healthy donors, patients recently diagnosed with MM, and MM patients in remission cohorts...
October 25, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27777769/clinical-significance-of-tumor-infiltrating-lymphocytes-in-breast-cancer
#5
Sasha E Stanton, Mary L Disis
Tumor infiltrating lymphocytes (TIL) play an essential role in mediating response to chemotherapy and improving clinical outcomes in all subtypes of breast cancer. Triple negative breast cancers (TN) are most likely to have tumors with >50 % lymphocytic infiltrate, termed lymphocyte predominant breast cancer, and derive the greatest survival benefit from each 10 % increase in TIL. The majority of HER2(+) breast cancers have similar level of immune infiltrate as TN breast cancer yet the presence of TILs has not shown the same survival benefit...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27775550/microrna-29b-mediates-altered-innate-immune-development-in-acute-leukemia
#6
Bethany L Mundy-Bosse, Steven D Scoville, Li Chen, Kathleen McConnell, Hsiaoyin C Mao, Elshafa H Ahmed, Nicholas Zorko, Sophia Harvey, Jordan Cole, Xiaoli Zhang, Stefan Costinean, Carlo M Croce, Karilyn Larkin, John C Byrd, Sumithira Vasu, William Blum, Jianhua Yu, Aharon G Freud, Michael A Caligiuri
Natural killer (NK) cells can have potent antileukemic activity following haplo-mismatched, T cell-depleted stem cell transplantations for the treatment of acute myeloid leukemia (AML), but they are not successful in eradicating de novo AML. Here, we have used a mouse model of de novo AML to elucidate the mechanisms by which AML evades NK cell surveillance. NK cells in leukemic mice displayed a marked reduction in the cytolytic granules perforin and granzyme B. Further, as AML progressed, we noted the selective loss of an immature subset of NK cells in leukemic mice and in AML patients...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27683080/tbet-deficiency-causes-t-helper-cell-dependent-airways-eosinophilia-and-mucus-hypersecretion-in-response-to-rhinovirus-infection
#7
Nicholas Glanville, Tamlyn J Peel, Armin Schröder, Julia Aniscenko, Ross P Walton, Susetta Finotto, Sebastian L Johnston
Current understanding of adaptive immune, particularly T cell, responses to human rhinoviruses (RV) is limited. Memory T cells are thought to be of a primarily T helper 1 type, but both T helper 1 and T helper 2 memory cells have been described, and heightened T helper 2/ lessened T helper 1 responses have been associated with increased RV-induced asthma exacerbation severity. We examined the contribution of T helper 1 cells to RV-induced airways inflammation using mice deficient in the transcription factor T-Box Expressed In T Cells (Tbet), a critical controller of T helper 1 cell differentiation...
September 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27601626/nk-cells-regulate-cxcr2-neutrophil-recruitment-during-acute-lung-injury
#8
Sandra Hoegl, Heidi Ehrentraut, Kelley S Brodsky, Francisco Victorino, Lucy Golden-Mason, Holger K Eltzschig, Eóin N McNamee
A critical step in the pathogenesis of acute lung injury (ALI) is excessive recruitment of polymorphonuclear neutrophils (PMNs) into the lungs, causing significant collateral tissue damage. Defining the molecular and cellular steps that control neutrophil infiltration and activation during ALI is therefore of important therapeutic relevance. Based on previous findings implicating the transcription factor Tbet in mucosal Th1-inflammation, we hypothesized a detrimental role for Tbet during ALI. In line with our hypothesis, initial studies of endotoxin-induced lung injury revealed a marked protection of Tbet(-/-) mice, including attenuated neutrophilia compared to WT counterparts...
September 6, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27576175/the-paracrine-immunomodulatory-interactions-between-the-human-dental-pulp-derived-mesenchymal-stem-cells-and-cd4-t-cell-subsets
#9
Alper Tunga Özdemir, Rabia Bilge Özgül Özdemir, Cengiz Kırmaz, Ayla Eker Sarıboyacı, Zehra Seda Ünal Halbutoğlları, Ceren Özel, Erdal Karaöz
Mesenchymal stem cells (MSCs) have strong immunomodulatory properties, however these properties may show some differences according to the tissue type of their isolate. In this study we investigated the paracrine interactions between human DP derived MSCs (hDP-MSCs) and the CD4(+) T helper cell subsets to establish their immunomodulatory mechanisms. We found that the CD4(+)-Tbet(+) (Th1) and CD4(+)-Gata3(+) (Th2) cells were suppressed by the hDP-MSCs, but the CD4(+)-Stat3(+) (Th17) and CD4(+)-CD25(+)-FoxP3(+) (Treg) cells were stimulated...
August 24, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27510432/a-red-emitting-two-photon-fluorescent-probe-for-dynamic-imaging-of-redox-balance-meditated-by-a-superoxide-anion-and-gsh-in-living-cells-and-tissues
#10
Hong-Wen Liu, Xiaoyan Zhu, Jing Zhang, Xiao-Bing Zhang, Weihong Tan
Cellular self-regulation of reactive oxygen species (ROS) stress via antioxidant repair plays an important role in maintaining the redox balance. The redox balance between reducing and oxidizing species within cells is significant in the regulation of a signal pathway and is achieved by a series of elaborate mechanisms. In this work, we employed our previously reported D-π-A-structured naphthalene-BODIPY TBET platform to design an efficient two-photon fluorescent probe for dynamic monitoring of superoxide anion oxidative stress and the GSH reducing repair process...
October 21, 2016: Analyst
https://www.readbyqxmd.com/read/27490575/highly-immunogenic-virally-vectored-t-cell-vaccines-cannot-overcome-subversion-of-the-t-cell-response-by-hcv-during-chronic-infection
#11
Leo Swadling, John Halliday, Christabel Kelly, Anthony Brown, Stefania Capone, M Azim Ansari, David Bonsall, Rachel Richardson, Felicity Hartnell, Jane Collier, Virginia Ammendola, Mariarosaria Del Sorbo, Annette Von Delft, Cinzia Traboni, Adrian V S Hill, Stefano Colloca, Alfredo Nicosia, Riccardo Cortese, Paul Klenerman, Antonella Folgori, Eleanor Barnes
An effective therapeutic vaccine for the treatment of chronic hepatitis C virus (HCV) infection, as an adjunct to newly developed directly-acting antivirals (DAA), or for the prevention of reinfection, would significantly reduce the global burden of disease associated with chronic HCV infection. A recombinant chimpanzee adenoviral (ChAd3) vector and a modified vaccinia Ankara (MVA), encoding the non-structural proteins of HCV (NSmut), used in a heterologous prime/boost regimen induced multi-specific, high-magnitude, durable HCV-specific CD4+ and CD8+ T-cell responses in healthy volunteers, and was more immunogenic than a heterologous Ad regimen...
August 2, 2016: Vaccines
https://www.readbyqxmd.com/read/27386265/increased-expression-of-tbet-in-cd4-t-cells-from-clinically-isolated-syndrome-patients-at-high-risk-of-conversion-to-clinically-definite-ms
#12
Sharee A Basdeo, Siobhan Kelly, Karen O'Connell, Niall Tubridy, Christopher McGuigan, Jean M Fletcher
BACKGROUND: The ability to identify clinically isolated syndrome (CIS) patients at high risk of progression to clinically definite multiple sclerosis (CDMS) would be clinically beneficial. The initiation of T cell mediated autoimmune diseases such as multiple sclerosis (MS) requires the initial inappropriate activation and differentiation of auto-reactive CD4(+) T cells. The quiescence of naive T cells is actively maintained by molecules such as TOB1, which control the threshold of activation...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27330109/transcription-factor-bcl11b-sustains-inkt1-and-inkt2-cell-programs-restricts-inkt17-cell-program-and-governs-inkt-cell-survival
#13
Mohammad Nizam Uddin, Dil Afroz Sultana, Kyle J Lorentsen, Jonathan J Cho, Mariana E Kirst, Mark L Brantly, Danielle Califano, Derek B Sant'Angelo, Dorina Avram
Invariant natural killer T (iNKT) cells are innate-like T cells that recognize glycolipid antigens and play critical roles in regulation of immune responses. Based on expression of the transcription factors (TFs) Tbet, Plzf, and Rorγt, iNKT cells have been classified in effector subsets that emerge in the thymus, namely, iNKT1, iNKT2, and iNKT17. Deficiency in the TF Bcl11b in double-positive (DP) thymocytes has been shown to cause absence of iNKT cells in the thymus and periphery due to defective self glycolipid processing and presentation by DP thymocytes and undefined intrinsic alterations in iNKT precursors...
July 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27222434/characterization-of-the-t-cell-response-to-dau-c-1-the-bet-v-1-homolog-in-carrot
#14
Nora Zulehner, Birgit Nagl, Peter Briza, Anargyros Roulias, Barbara Ballmer-Weber, Gerhard Johann Zlabinger, Fatima Ferreira, Barbara Bohle
BACKGROUND: In contrast to other Bet v 1-related food allergens, the major carrot allergen, Dau c 1, has been suggested to induce food allergy independently from Bet v 1. As T cells are crucial in the sensitization process we sought to characterize the T cell response to Dau c 1 and its cross-reactivity with Bet v 1. METHODS: Dau c 1-specific T cell lines (TCL) and clones (TCC) established from PBMC of birch pollen-allergic patients with carrot allergy were analyzed for reactivity to Bet v 1, epitope-specificity, allergen-induced cytokine secretion and expression of integrins α4β7 and α4β1, critical for gut and lung homing, respectively...
May 25, 2016: Allergy
https://www.readbyqxmd.com/read/27198569/pd-l1-expression-in-colorectal-cancer-is-associated-with-microsatellite-instability-braf-mutation-medullary-morphology-and-cytotoxic-tumor-infiltrating-lymphocytes
#15
Matthew W Rosenbaum, Jacob R Bledsoe, Vicente Morales-Oyarvide, Tiffany G Huynh, Mari Mino-Kenudson
Programmed cell death 1 (PD-1) and its ligand (PD-L1) are key suppressors of the cytotoxic immune response. PD-L1 expression on tumor cells may be induced by the immune microenvironment, resulting in immune escape (adaptive immune resistance), and an adverse prognosis in many malignancies. In colorectal carcinoma the response to PD-1/PD-L1 inhibition is correlated with microsatellite instability. However, little is known about the clinicopathologic, molecular, and prognostic characteristics of colorectal carcinoma with PD-L1 expression...
September 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27183623/tbet-or-continued-ror%C3%AE-t-expression-is-not-required-for-th17-associated-immunopathology
#16
Verena Brucklacher-Waldert, Cristina Ferreira, Silvia Innocentin, Shraddha Kamdar, David R Withers, Marika C Kullberg, Marc Veldhoen
The discovery of Th17 cell plasticity, in which CD4(+) IL-17-producing Th17 cells give rise to IL-17/IFN-γ double-producing cells and Th1-like IFNγ(+) ex-Th17 lymphocytes, has raised questions regarding which of these cell types contribute to immunopathology during inflammatory diseases. In this study, we show using Helicobacter hepaticus-induced intestinal inflammation that IL-17A(Cre)- or Rag1(Cre)-mediated deletion of Tbx21 has no effect on the generation of IL-17/IFN-γ double-producing cells, but leads to a marked absence of Th1-like IFNγ(+) ex-Th17 cells...
June 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27144496/influence-of-donor-on-the-sensing-performance-of-a-series-of-through-bond-energy-transfer-based-two-photon-fluorescent-cu-2-probes
#17
Yu-Jin Zhang, Xin Wang, Yong Zhou, Chuan-Kui Wang
Optical properties of a series of molecular two-photon fluorescent Cu(2+) probes containing the same acceptor (rhodamine group) are analyzed using time-dependent density functional theory in combination with analytical response theory. Special emphasis is placed on evolution of the probes' optical properties in the presence of Cu(2+) . In this study, the compound with naphthalene as the donor is shown to be excellent ratiometric fluorescent chemosensor, whereas the compound with quinoline derivative as the donor shows off/on-typed colorimetric fluorescent response...
July 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27057426/tumor-infiltration-by-tbet-effector-t-cells-and-cd20-b-cells-is-associated-with-survival-in-gastric-cancer-patients
#18
Audrey Hennequin, Valentin Derangère, Romain Boidot, Lionel Apetoh, Julie Vincent, David Orry, Jean Fraisse, Sylvain Causeret, François Martin, Laurent Arnould, Françoise Beltjens, François Ghiringhelli, Sylvain Ladoire
Tumor-infiltrating T and B lymphocytes could have the potential to affect cancer prognosis. The objective of this study was to investigate the prognostic significance of tumor infiltration by CD8 and CD4 T cells, and B lymphocytes in patients with localized gastric cancer. In a retrospective cohort of 82 patients with localized gastric cancer and treated by surgery we quantitatively assessed by immunohistochemistry on surgical specimen, immune infiltrates of IL-17(+), CD8(+), Foxp3(+), Tbet(+) T cells and CD20(+) B cells both in the tumor core and at the invasive margin via immunohistochemical analyses of surgical specimens...
February 2016: Oncoimmunology
https://www.readbyqxmd.com/read/26887440/corticosteroid-modulation-of-immunoglobulin-expression-and-b-cell-function-in-copd
#19
Jin Lee, Matthew Machin, Kirsty E Russell, Stelios Pavlidis, Jie Zhu, Peter J Barnes, Kian F Chung, Ian M Adcock, Andrew L Durham
We investigated changes in gene expression that occur in chronic obstructive pulmonary disease (COPD) after corticosteroid treatment and sought to identify the mechanisms that regulate these changes. Biopsy samples were taken from patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage I to II) before and after treatment with fluticasone propionate (FP)/salmeterol (SM) (50/500, 4 wk). Gene expression was measured by microarray and was confirmed by real-time reverse transcription-quantitative PCR (RT-qPCR)...
May 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/26880074/id2-regulates-hyporesponsive-invariant-natural-killer-t-cells
#20
Martin H Stradner, Kitty P Cheung, Anna Lasorella, Ananda W Goldrath, Louise M D'Cruz
While the invariant natural killer T (iNKT)-cell response to primary stimulation with the glycolipid, α-galactosylceramide (αGalCer), is robust, the secondary response to this stimulus is muted resulting in a hyporesponsive state characterized by anti-inflammatory interleukin-10 (IL-10) production and high expression of programmed cell death 1 (PD1) and neuropilin 1 (NRP1). The E protein transcription factors and their negative regulators, the Id proteins, have previously been shown to regulate iNKT cell thymic development, subset differentiation and peripheral survival...
August 2016: Immunology and Cell Biology
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