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https://www.readbyqxmd.com/read/28412624/effects-of-1-25-dihydroxyvitamin-d3-in-an-ovalbumin-induced-allergic-rhinitis-model
#1
Baiwen Chen, Shenhong Qu, Min Li, Linsong Ye, Shaojie Zhang, Taijie Qin, Hua Fan
IL-17-producing Th17 cells play an important role in allergic airway diseases, but their local expression and regulation in allergic rhinitis (AR) is not well understood. This study investigated the effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on T-bet expression, Th1 cells, Th2 cells, Th17 cells and IL-33-positive epithelial cells in AR. C57BL/6 mice were intranasally sensitized and challenged with ovalbumin (OVA), and 1,25-(OH)2D3 was intraperitoneally injected into AR mice. Cytokine levels were measured with enzyme-linked immunosorbent assays, phenotypic analysis of Th1, Th2 and Th17 cells in the spleen was completed with flow cytometry, and the CD4(+)IL-17(+) cells in the Nasopharynx-associated lymphoid tissue (NALT) and IL-33-positive cells in nasal mucosa was evaluated with immunofluorescence microscopy...
April 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28406139/t-bet-independent-development-of-ifn%C3%AE-secreting-natural-t-helper-1-cell-population-in-the-absence-of-itk
#2
Arun K Kannan, Sonia Mohinta, Weishan Huang, Lu Huang, Nicholas Koylass, Judith A Appleton, Avery August
Th1, Th2, Th9 and Th17 cells are conventional CD4(+) effector T cells identified as secretors of prototypical cytokines IFNγ, IL4, IL9, and IL-17A respectively. Recently, populations of natural Th17 and Th1 cells (nTh17 and nTh1) with innate-like phenotype have been identified in the thymus that are distinct from conventional Th17 and Th1 cells. The absence of the Tec family kinase Interleukin-2 inducible T cell kinase (Itk) results in T cell immunodeficiency in mice and humans. Here we show that Itk negatively regulates the development of nTh1 cells that express IFNγ in a Tbet independent manner, and whose expansion can be enhanced by IL4...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28276053/murine-thymic-nk-cells-are-distinct-from-ilc1s-and-have-unique-transcription-factor-requirements
#3
Sara Gabrielli, Mengxi Sun, April Bell, Erin C Zook, Renee F de Pooter, Loris Zamai, Barbara L Kee
Group 1 innate lymphoid cells include natural killer (NK) cells and ILC1s, which mediate the response to intracellular pathogens. Thymic NK (tNK) cells were described with hybrid features of immature NK cells and ILC1 but whether these cells are related to NK cells or ILC1 has not been fully investigated. We report that murine tNK cells expressed the NK-cell associated transcription factor EOMES and developed independent of the essential ILC1 factor TBET, confirming their placement within the NK lineage. Moreover, tNK cells resemble NK cells rather than ILC1 in their requirements for the E protein transcription factor inhibitor ID2...
March 9, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28197386/deficiency-of-the-immunostimulatory-cytokine-il-21-promotes-intestinal-neoplasia-via-dysregulation-of-the-th1-th17-axis
#4
Mia Shapiro, Bisweswar Nandi, Gabriel Gonzalez, Rao H Prabhala, Hiroshi Mashimo, Qin Huang, Natasha Y Frank, Nikhil C Munshi, Jason S Gold
IL-21 has reported activity in promoting both Th1 and Th17 immune responses. Its role in sporadic human colorectal cancer is unknown. We aimed to delineate the role of IL-21 in a model of sporadic intestinal carcinogenesis. We found that in APC(MIN/+) mice, ablation of IL-21 increased intestinal tumorigenesis. Expression of pro-inflammatory Th17-associated genes, including RORγt and IL-17A, was increased in the intestine in the absence of IL-21, while expression of antitumor Th1-associated genes Tbet, IFNγ, granzyme B, and perforin was decreased...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28197372/fam13a-is-associated-with-non-small-cell-lung-cancer-nsclc-progression-and-controls-tumor-cell-proliferation-and-survival
#5
Felix Eisenhut, Lisanne Heim, Sonja Trump, Susanne Mittler, Nina Sopel, Katerina Andreev, Fulvia Ferrazzi, Arif B Ekici, Ralf Rieker, Rebekka Springel, Vera L Assmann, Matthias Lechmann, Sonja Koch, Marina Engelhardt, Christina Warnecke, Denis I Trufa, Horia Sirbu, Arndt Hartmann, Susetta Finotto
Genome-wide association studies (GWAS) associated Family with sequence similarity 13, member A (FAM13A) with non-small cell lung cancer (NSCLC) occurrence. Here, we found increased numbers of FAM13A protein expressing cells in the tumoral region of lung tissues from a cohort of patients with NSCLC. Moreover, FAM13A inversely correlated with CTLA4 but directly correlated with HIF1α levels in the control region of these patients. Consistently, FAM13A RhoGAP was found to be associated with T cell effector molecules like HIF1α and Tbet and was downregulated in immunosuppressive CD4(+)CD25(+)Foxp3(+)CTLA4(+) T cells...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28100680/th22-cells-form-a-distinct-th-lineage-from-th17-cells-in-vitro-with-unique-transcriptional-properties-and-tbet-dependent-th1-plasticity
#6
Maximilian W Plank, Gerard E Kaiko, Steven Maltby, Jessica Weaver, Hock L Tay, Wei Shen, Mark S Wilson, Scott K Durum, Paul S Foster
Th22 cells are a major source of IL-22 and have been found at sites of infection and in a range of inflammatory diseases. However, their molecular characteristics and functional roles remain largely unknown because of our inability to generate and isolate pure populations. We developed a novel Th22 differentiation assay and generated dual IL-22/IL-17A reporter mice to isolate and compare pure populations of cultured Th22 and Th17 cells. Il17a fate-mapping and transcriptional profiling provide evidence that these Th22 cells have never expressed IL-17A, suggesting that they are potentially a distinct cell lineage from Th17 cells under in vitro culture conditions...
March 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28012941/age-related-arterial-immune-cell-infiltration-in-mice-is-attenuated-by-caloric-restriction-or-voluntary-exercise
#7
Daniel W Trott, Grant D Henson, Mi H T Ho, Sheilah A Allison, Lisa A Lesniewski, Anthony J Donato
Age-related arterial inflammation is associated with dysfunction of the arteries and increased risk for cardiovascular disease. To determine if aging increases arterial immune cell infiltration as well as the populations of immune cells principally involved, we tested the hypothesis that large elastic and resistance arteries in old mice would exhibit increased immune cell infiltration compared to young controls. Additionally, we hypothesized that vasoprotective lifestyle interventions such as lifelong caloric restriction or 8weeks of voluntary wheel running would attenuate age-related arterial immune cell infiltration...
December 22, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27966635/boosting-adaptive-immunity-a-new-role-for-pafr-antagonists
#8
Marianna M Koga, Bruna Bizzarro, Anderson Sá-Nunes, Francisco J Rios, Sonia Jancar
We have previously shown that the Platelet-Activating Factor Receptor (PAFR) engagement in murine macrophages and dendritic cells (DCs) promotes a tolerogenic phenotype reversed by PAFR-antagonists treatment in vitro. Here, we investigated whether a PAFR antagonist would modulate the immune response in vivo. Mice were subcutaneously injected with OVA or OVA with PAFR-antagonist WEB2170 on days 0 and 7. On day 14, OVA-specific IgG2a and IgG1 were measured in the serum. The presence of WEB2170 during immunization significantly increased IgG2a without affecting IgG1 levels...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27866814/predictors-of-tissue-healing-in-ulcerative-colitis-patients-treated-with-anti-tnf
#9
Nikos Viazis, Marios Giakoumis, Giorgos Bamias, Dimitris Goukos, Theodoros Koukouratos, Konstantina Katopodi, Pantelis Karatzas, Christos Triantos, Chrisostomos Tsolias, Georgios Theocharis, George L Daikos, Spyros D Ladas, Dimitrios G Karamanolis, Gerasimos J Mantzaris
AIM: To identify factors predicting mucosal healing in ulcerative colitis patients treated with anti-TNFα agents with or without azathioprine. METHODS: In a prospective, multicenter, one-year study biologic naïve patients aged 25-65 years, with corticosteroid-dependent or refractory colitis received combination treatment with anti-TNFα and azathioprine for 6 months followed by anti-TNFα monotherapy. Patients who denied combination therapy or were outside this age range received anti-TNFα monotherapy (controls)...
January 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27814345/pro-inflammatory-immune-responses-in-leukocytes-of-premature-infants-exposed-to-maternal-chorioamnionitis-or-funisitis
#10
Courtney M Jackson, Casey B Wells, Meredith E Tabangin, Jareen Meinzen-Derr, Alan H Jobe, Claire A Chougnet
BACKGROUND: Acute chorioamnionitis contributes to premature birth, and is associated with postbirth complications. How chorioamnionitis impacts neonate's developing immune system has not been well defined. METHODS: Blood from extremely preterm infants (≤28 wk gestation) was drawn at the first, second, and fourth week of life. Blood was either left unstimulated or stimulated for 4 h with PMA/ionomycin. mRNA expression of transcription factors in unstimulated cells (RORC, TBET, GATA3, and Forkhead box protein 3 (FOXP3)) and inflammatory cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-5, and IL-6) in unstimulated and stimulated cells were analyzed...
February 2017: Pediatric Research
https://www.readbyqxmd.com/read/27793998/mapping-the-fetomaternal-peripheral-immune-system-at-term-pregnancy
#11
Gabriela K Fragiadakis, Quentin J Baca, Pier Federico Gherardini, Edward A Ganio, Dyani K Gaudilliere, Martha Tingle, Hope L Lancero, Leslie S McNeil, Matthew H Spitzer, Ronald J Wong, Gary M Shaw, Gary L Darmstadt, Karl G Sylvester, Virginia D Winn, Brendan Carvalho, David B Lewis, David K Stevenson, Garry P Nolan, Nima Aghaeepour, Martin S Angst, Brice L Gaudilliere
Preterm labor and infections are the leading causes of neonatal deaths worldwide. During pregnancy, immunological cross talk between the mother and her fetus is critical for the maintenance of pregnancy and the delivery of an immunocompetent neonate. A precise understanding of healthy fetomaternal immunity is the important first step to identifying dysregulated immune mechanisms driving adverse maternal or neonatal outcomes. This study combined single-cell mass cytometry of paired peripheral and umbilical cord blood samples from mothers and their neonates with a graphical approach developed for the visualization of high-dimensional data to provide a high-resolution reference map of the cellular composition and functional organization of the healthy fetal and maternal immune systems at birth...
December 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27793666/characterization-of-%C3%AE-%C3%AE-regulatory-t-cells-from-peripheral-blood-in-patients-with-multiple-myeloma
#12
M A Yongyong, Huyi Lei, Jie Tan, Xuan Li, Xiuli Wu, Qifa Liu
γδ regulatory T cells are able to inhibit the activation and function of T cells involved in antigen-specific immune responses. This study aimed to investigate the potential role of γδ regulatory T cells in inhibiting anti-tumor immune responses in patients diagnosed as multiple myeloma (MM). We measured the levels of γδ T cells, the distribution and clonally amplified TCR Vγ and VδT cells in peripheral blood of healthy donors, patients recently diagnosed with MM, and MM patients in remission cohorts...
October 25, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27777769/clinical-significance-of-tumor-infiltrating-lymphocytes-in-breast-cancer
#13
REVIEW
Sasha E Stanton, Mary L Disis
Tumor infiltrating lymphocytes (TIL) play an essential role in mediating response to chemotherapy and improving clinical outcomes in all subtypes of breast cancer. Triple negative breast cancers (TN) are most likely to have tumors with >50 % lymphocytic infiltrate, termed lymphocyte predominant breast cancer, and derive the greatest survival benefit from each 10 % increase in TIL. The majority of HER2(+) breast cancers have similar level of immune infiltrate as TN breast cancer yet the presence of TILs has not shown the same survival benefit...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27775550/microrna-29b-mediates-altered-innate-immune-development-in-acute-leukemia
#14
Bethany L Mundy-Bosse, Steven D Scoville, Li Chen, Kathleen McConnell, Hsiaoyin C Mao, Elshafa H Ahmed, Nicholas Zorko, Sophia Harvey, Jordan Cole, Xiaoli Zhang, Stefan Costinean, Carlo M Croce, Karilyn Larkin, John C Byrd, Sumithira Vasu, William Blum, Jianhua Yu, Aharon G Freud, Michael A Caligiuri
Natural killer (NK) cells can have potent antileukemic activity following haplo-mismatched, T cell-depleted stem cell transplantations for the treatment of acute myeloid leukemia (AML), but they are not successful in eradicating de novo AML. Here, we have used a mouse model of de novo AML to elucidate the mechanisms by which AML evades NK cell surveillance. NK cells in leukemic mice displayed a marked reduction in the cytolytic granules perforin and granzyme B. Further, as AML progressed, we noted the selective loss of an immature subset of NK cells in leukemic mice and in AML patients...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27683080/tbet-deficiency-causes-t-helper-cell-dependent-airways-eosinophilia-and-mucus-hypersecretion-in-response-to-rhinovirus-infection
#15
Nicholas Glanville, Tamlyn J Peel, Armin Schröder, Julia Aniscenko, Ross P Walton, Susetta Finotto, Sebastian L Johnston
Current understanding of adaptive immune, particularly T cell, responses to human rhinoviruses (RV) is limited. Memory T cells are thought to be of a primarily T helper 1 type, but both T helper 1 and T helper 2 memory cells have been described, and heightened T helper 2/ lessened T helper 1 responses have been associated with increased RV-induced asthma exacerbation severity. We examined the contribution of T helper 1 cells to RV-induced airways inflammation using mice deficient in the transcription factor T-Box Expressed In T Cells (Tbet), a critical controller of T helper 1 cell differentiation...
September 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27601626/nk-cells-regulate-cxcr2-neutrophil-recruitment-during-acute-lung-injury
#16
Sandra Hoegl, Heidi Ehrentraut, Kelley S Brodsky, Francisco Victorino, Lucy Golden-Mason, Holger K Eltzschig, Eóin N McNamee
A critical step in the pathogenesis of acute lung injury (ALI) is excessive recruitment of polymorphonuclear neutrophils (PMNs) into the lungs, causing significant collateral tissue damage. Defining the molecular and cellular steps that control neutrophil infiltration and activation during ALI is therefore of important therapeutic relevance. Based on previous findings implicating the transcription factor Tbet in mucosal Th1-inflammation, we hypothesized a detrimental role for Tbet during ALI. In line with our hypothesis, initial studies of endotoxin-induced lung injury revealed a marked protection of Tbet(-/-) mice, including attenuated neutrophilia compared to WT counterparts...
September 6, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27576175/the-paracrine-immunomodulatory-interactions-between-the-human-dental-pulp-derived-mesenchymal-stem-cells-and-cd4-t-cell-subsets
#17
Alper Tunga Özdemir, Rabia Bilge Özgül Özdemir, Cengiz Kırmaz, Ayla Eker Sarıboyacı, Zehra Seda Ünal Halbutoğlları, Ceren Özel, Erdal Karaöz
Mesenchymal stem cells (MSCs) have strong immunomodulatory properties, however these properties may show some differences according to the tissue type of their isolate. In this study we investigated the paracrine interactions between human DP derived MSCs (hDP-MSCs) and the CD4(+) T helper cell subsets to establish their immunomodulatory mechanisms. We found that the CD4(+)-Tbet(+) (Th1) and CD4(+)-Gata3(+) (Th2) cells were suppressed by the hDP-MSCs, but the CD4(+)-Stat3(+) (Th17) and CD4(+)-CD25(+)-FoxP3(+) (Treg) cells were stimulated...
August 24, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27510432/a-red-emitting-two-photon-fluorescent-probe-for-dynamic-imaging-of-redox-balance-meditated-by-a-superoxide-anion-and-gsh-in-living-cells-and-tissues
#18
Hong-Wen Liu, Xiaoyan Zhu, Jing Zhang, Xiao-Bing Zhang, Weihong Tan
Cellular self-regulation of reactive oxygen species (ROS) stress via antioxidant repair plays an important role in maintaining the redox balance. The redox balance between reducing and oxidizing species within cells is significant in the regulation of a signal pathway and is achieved by a series of elaborate mechanisms. In this work, we employed our previously reported D-π-A-structured naphthalene-BODIPY TBET platform to design an efficient two-photon fluorescent probe for dynamic monitoring of superoxide anion oxidative stress and the GSH reducing repair process...
October 21, 2016: Analyst
https://www.readbyqxmd.com/read/27490575/highly-immunogenic-virally-vectored-t-cell-vaccines-cannot-overcome-subversion-of-the-t-cell-response-by-hcv-during-chronic-infection
#19
Leo Swadling, John Halliday, Christabel Kelly, Anthony Brown, Stefania Capone, M Azim Ansari, David Bonsall, Rachel Richardson, Felicity Hartnell, Jane Collier, Virginia Ammendola, Mariarosaria Del Sorbo, Annette Von Delft, Cinzia Traboni, Adrian V S Hill, Stefano Colloca, Alfredo Nicosia, Riccardo Cortese, Paul Klenerman, Antonella Folgori, Eleanor Barnes
An effective therapeutic vaccine for the treatment of chronic hepatitis C virus (HCV) infection, as an adjunct to newly developed directly-acting antivirals (DAA), or for the prevention of reinfection, would significantly reduce the global burden of disease associated with chronic HCV infection. A recombinant chimpanzee adenoviral (ChAd3) vector and a modified vaccinia Ankara (MVA), encoding the non-structural proteins of HCV (NSmut), used in a heterologous prime/boost regimen induced multi-specific, high-magnitude, durable HCV-specific CD4+ and CD8+ T-cell responses in healthy volunteers, and was more immunogenic than a heterologous Ad regimen...
August 2, 2016: Vaccines
https://www.readbyqxmd.com/read/27386265/increased-expression-of-tbet-in-cd4-t-cells-from-clinically-isolated-syndrome-patients-at-high-risk-of-conversion-to-clinically-definite-ms
#20
Sharee A Basdeo, Siobhan Kelly, Karen O'Connell, Niall Tubridy, Christopher McGuigan, Jean M Fletcher
BACKGROUND: The ability to identify clinically isolated syndrome (CIS) patients at high risk of progression to clinically definite multiple sclerosis (CDMS) would be clinically beneficial. The initiation of T cell mediated autoimmune diseases such as multiple sclerosis (MS) requires the initial inappropriate activation and differentiation of auto-reactive CD4(+) T cells. The quiescence of naive T cells is actively maintained by molecules such as TOB1, which control the threshold of activation...
2016: SpringerPlus
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