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toll like receptor 11

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https://www.readbyqxmd.com/read/29780528/synthetic-glycan-based-tlr4-agonists-targeting-caspase-4-11-for-the-development-of-adjuvants-and-immunotherapeutics
#1
Florian Adanitsch, Jianjin Shi, Feng Shao, Rudi Beyaert, Holger Heine, Alla Zamyatina
Gram-negative bacterial lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) mediated pro-inflammatory signaling plays a key role in immunoprotection against infectious challenges and boosts adaptive immunity, whereas the activation of the cytosolic LPS receptor caspase-4/11 leads to cell death by pyroptosis and is deeply implicated in the development of sepsis. Despite tremendous advances in the understanding of the LPS-TLR4 interaction, predictably regulated TLR4 activation has not yet been achieved...
April 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29767328/a-placebo-controlled-efficacy-study-of-the-intravesical-immunomodulators-tmx-101-and-tmx-202-in-an-orthotopic-bladder-cancer-rat-model
#2
Johannes Falke, Christina A Hulsbergen-van de Kaa, Roberto Maj, Egbert Oosterwijk, J Alfred Witjes
PURPOSE: TMX-101 and TMX-202 are formulations of toll-like receptor 7 (TLR-7) agonists, under investigation for the treatment of urothelial carcinoma. Our goal was to evaluate the efficacy of intravesical instillations of TMX-101 or TMX-202 in an orthotopic bladder cancer rat model. METHODS: Four groups of 14 rats received an instillation with isogenic AY-27 tumor cells on day 0, starting tumor development. On day 2 and 5, the rats were treated with an intravesical instillation of TMX-101 0...
May 16, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29764544/-effects-of-peroxisome-proliferator-activated-receptor-%C3%AE-toll-like-receptor-4-tumor-necrosis-factor-%C3%AE-targeted-pathway-on-hyperglycemia-induced-myocardium-inflammation-and-oxidative-stress
#3
Changle Liu, Ruimeng Liu, Xiaohan Wu, Peize Tan, Huaying Fu, Xinghua Wang, Tong Liu, Guangping Li
OBJECTIVE: To investigate the potential effects and mechanism on peroxisome proliferator-activated receptor γ-toll-like receptor 4-tumor necrosis factor-α (PPARγ-TLR4-TNF-α) targeted pathway on hyperglycemia induced myocardium inflammation and oxidative stress. METHODS: Thirty-two Japanese healthy adult rabbits were randomly divided into four groups with 8 rabbits in each group: normal control group (NC group), diabetes mellitus group (DM group), diabetes mellitus + pioglitazone 4 mg×kg-1 ×d-1 and 8 mg×kg-1 ×d-1 groups (DM+PGZ 4 mg and 8 mg groups)...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29753770/molecular-characterization-and-expression-analysis-of-tlr1-and-tlr4-from-the-endangered-fish-dabry-s-sturgeon-acipenser-dabryanus
#4
Panpan Han, Sisi Wang, Qihuan Zhang, Shuhuan Zhang, Rong Shao, Wei Xu, Wenbing Zhang, Qiaoqing Xu, Qiwei Wei, Zhitao Qi
Toll-like receptors (TLRs) are important pattern recognition receptors (PRRs) of teleost innate immune system. However, information about TLRs is absent in Dabry's sturgeon (Acipenser dabryanus), one of the most primitive actinopterygii species. In the present study, the full lengths of adaTLR1 and adaTLR4 were cloned from Dabry's sturgeon using RT-PCR and RACE-PCR. The obtained adaTLR1 was 2957 bp in length, encoding a putative protein of 767 amino acids and adaTLR4 cDNA was 2902 bp in length, encoding a putative protein of 830 aa...
May 10, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29726281/exopolysaccharide-from-bifidobacterium-longum-subsp-longum-35624%C3%A2-modulates-murine-allergic-airway-responses
#5
E Schiavi, S Plattner, N Rodriguez-Perez, W Barcik, R Frei, R Ferstl, M Kurnik-Lucka, D Groeger, R Grant, J Roper, F Altmann, D van Sinderen, C A Akdis, L O'Mahony
Interactions between the host and the microbiota are thought to significantly influence immunological tolerance mechanisms at mucosal sites. We recently described that the loss of an exopolysaccharide (EPS) from Bifidobacterium longum 35624™ eliminated its protective effects in colitis and respiratory allergy murine models. Our goal was to investigate the immune response to purified EPS from B. longum 35624, determine if it has protective effects within the lung and identify the protective mechanisms. Isolated EPS from B...
May 4, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29685478/postprandial-endotoxemia-may-influence-the-development-of-type-2-diabetes-mellitus-from-the-cordioprev-study
#6
Antonio Camargo, Rosa Jimenez-Lucena, Juan F Alcala-Diaz, Oriol A Rangel-Zuñiga, Sonia Garcia-Carpintero, Javier Lopez-Moreno, Ruth Blanco-Rojo, Javier Delgado-Lista, Pablo Perez-Martinez, Ben van Ommen, Maria M Malagon, Jose M Ordovas, Francisco Perez-Jimenez, Jose Lopez-Miranda
BACKGROUND & AIMS: Insulin resistance (IR) and impaired beta-cell function are key determinants of type 2 diabetes mellitus (T2DM). Intestinal absorption of bacterial components activates the toll-like receptors inducing inflammation, and this in turn IR. We evaluated the role of endotoxemia in promoting inflammation-induced insulin resistance (IR) in the development of T2DM, and its usefulness as predictive biomarker. METHODS: We included in this study 462 patients from the CORDIOPREV study without T2DM at baseline...
April 11, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29684378/identification-of-a-pyrrogallol-derivative-as-a-potent-and-selective-human-tlr2-antagonist-by-structure-based-virtual-screening
#7
Maria Grabowski, Manuela S Murgueitio, Marcel Bermudez, Jörg Rademann, Gerhard Wolber, Günther Weindl
Toll-like receptor 2 (TLR2) induces early inflammatory responses to pathogen and damage-associated molecular patterns trough heterodimerization with either TLR1 or TLR6. Since overstimulation of TLR2 signaling is linked to several inflammatory and metabolic diseases, TLR2 antagonists may provide therapeutic benefits for the control of inflammatory conditions. We present virtual screening for the identification of novel TLR2 modulators, which combines analyses of known ligand sets with structure-based approaches...
April 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29670922/clinicopathological-features-and-increased-expression-of-toll-like-receptor-4-of-gastric-cardia-cancer-in-a-high-risk-chinese-population
#8
Guangcan Chen, Muming Xu, Jingyao Chen, Liangli Hong, Wenting Lin, Shukun Zhao, Guohong Zhang, Guo Dan, Shuhui Liu
The incidence of gastric cardia cancer (GCC) is high in China. However, the clinicopathological characteristics and the carcinogenesis of GCC are unclear. Toll-like receptor 4 (TLR4) is an important innate immunity receptor and has a role in non-GCC (NGCC). We compared the clinicopathological characteristics of GCC patients from a high-risk area in China to esophageal cancer (EC) patients. Immunohistochemistry for TLR4 was performed in 201 histological samples of normal gastric cardia mucosa ( n = 11), gastric cardia inflammation ( n = 87), and GCC ( n = 103)...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29661854/targeting-toll-like-receptors-in-cancer-prevention
#9
EDITORIAL
Karen S Sfanos
There is a pressing need for the development of new prevention strategies for the most common worldwide malignancy, nonmelanoma skin cancer (NMSC), as sun protection efforts have not proven to be completely effective. Interestingly, despite the known circumstance that individuals undergoing chronic immunosuppression are at a substantially increased risk for developing NMSC, in this issue of Cancer Prevention Research , Blohm-Mangone and colleagues provide new evidence that topical application of the Toll-like receptor 4 (TLR4) antagonist resatorvid may be efficacious as a chemopreventive agent in NMSC specifically via blocking UV-induced inflammatory signaling...
April 16, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29661181/tlr4-modulates-inflammatory-gene-targets-in-the-retina-during-bacillus-cereus-endophthalmitis
#10
Phillip S Coburn, Frederick C Miller, Austin L LaGrow, Salai Madhumathi Parkunan, C Blake Randall, Rachel L Staats, Michelle C Callegan
BACKGROUND: Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation during endophthalmitis, more rational targets are needed. Toll-like receptors (TLRs) recognize specific motifs on invading pathogens and initiate the innate inflammatory response. We reported that TLR4 contributes to the robust inflammation which is a hallmark of Bacillus cereus endophthalmitis...
April 16, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29602972/the-potential-role-of-toll-like-receptor-4-asp299gly-polymorphism-and-its-association-with-recurrent-cystic-echinococcosis-in-postoperative-patients
#11
Jafar Noori, Adel Spotin, Ehsan Ahmadpour, Mahmoud Mahami-Oskouei, Homayoun Sadeghi-Bazargani, Tohid Kazemi, Ebrahim Sakhinia, Leili Aghebati-Maleki, Firooz Shahrivar
The study of pathogenesis mechanisms of larval stages in the Taeniidae has recently focused on host genetic factors, particularly toll-like receptor (TLR) variations. However, the potential role of TLR4 polymorphism in hydatidosis has not yet been sufficiently elucidated in postoperative patients. In this case-control investigation, 80 patients from Iran, including 40 with acute hydatidosis (AH) and 40 with recurrent hydatidosis (RH), and 80 ethnically matched controls were evaluated from February 2015 to February 2017...
March 30, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29575556/development-of-a-vaccine-based-on-bacteria-mimicking-tumor-cells-coated-with-novel-engineered-tlr2-ligands
#12
Takashi Akazawa, Toshimitsu Ohashi, Viskam Wijewardana, Kikuya Sugiura, Norimitsu Inoue
For a successful tumor vaccine, it is necessary to develop effective immuno-adjuvants and identify specific tumor antigens. Tumor cells obtained from surgical or biopsy tissues are a good source of tumor antigens but, unlike bacteria, they do not induce strong immune responses. Here, we designed two novel lipopeptides that coat tumor cell surfaces and mimic bacterial components. Tumor cells coated with these lipopeptides (called bacteria-mimicking tumor cells (BMTCs)) were prepared and their efficacy as a tumor vaccine examined...
March 25, 2018: Cancer Science
https://www.readbyqxmd.com/read/29562634/transcriptome-analysis-of-epithelioma-papulosum-cyprini-cells-infected-by-reovirus-isolated-from-allogynogenetic-silver-crucian-carp
#13
Cui-Yu Ba, Xiao-Yan Du, Pei-Jun Zhang, Ping Chen, Ya-Nan Cai, Yue-Hong Li
The present study aimed to identify differentially expressed genes (DEGs) and major signal transduction pathways that were related to the immune response of epithelioma papulosum cyprinid (EPC) cells to reoviruses isolated from allogynogenetic silver crucian carp. The study also lays a theoretical foundation for the pathogenesis and immunity of the reovirus, which is helpful to the breeding of cyprinids fish. Reovirus infected and uninfected EPC cells were analyzed by using a new-generation high-throughput sequencing technology...
March 18, 2018: Viruses
https://www.readbyqxmd.com/read/29560134/role-of-tlr4-as-a-prognostic-factor-for-survival-in-various-cancers-a-meta-analysis
#14
Bo Hao, Zhen Chen, Baochen Bi, Miaomei Yu, Shuang Yao, Yuehua Feng, Yang Yu, Lili Pan, Dongmei Di, Guanghua Luo, Xiaoying Zhang
Background: Accumulating evidence showed that high expression of toll like receptor 4 (TLR4) was significantly associated with the outcome of patients with solid cancers. However, other studies failed to draw a similar conclusion. Thus, a systematic meta-analysis was performed to assess the prognostic value of TLR4 in solid tumors. Results: Data from 15 studies and 1294 patients were enrolled. Among the 15 studies, 14 studies demonstrated the association between overall survival(OS) and TLR4 expression, and 7 studies described the relationship between disease-free survival(DFS) and TLR4 expression...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29552131/integrated-analysis-of-microarray-data-to-identify-the-genes-critical-for-the-rupture-of-intracranial-aneurysm
#15
Liang Wei, Qi Wang, Yanfei Zhang, Cheng Yang, Hongxin Guan, Jianxin Jiang, Zhiyang Sun
Intracranial aneurysm (IA) is a localized dilation of the blood vessel. The present study was designed to explore the mechanisms of rupture of IA. GSE13353 (including 11 ruptured and 8 unruptured IA samples) and GSE15629 (including 8 ruptured and 6 unruptured IA samples) were downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) identified using limma and MetaDE packages were merged, and a protein-protein interaction (PPI) network analysis was performed using Cytoscape software...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29543867/toll-like-receptors-2-4-and-9-expressions-over-the-entire-clinical-and-immunopathological-spectrum-of-american-cutaneous-leishmaniasis-due-to-leishmania-v-braziliensis-and-leishmania-l-amazonensis
#16
Marliane Batista Campos, Luciana Vieira do Rêgo Lima, Ana Carolina Stocco de Lima, Thiago Vasconcelos Dos Santos, Patrícia Karla Santos Ramos, Claudia Maria de Castro Gomes, Fernando Tobias Silveira
Leishmania (V.) braziliensis and Leishmania(L.) amazonensis are the most pathogenic agents of American Cutaneous Leishmaniasis in Brazil, causing a wide spectrum of clinical and immunopathological manifestations, including: localized cutaneous leishmaniasis (LCLDTH+/++), borderline disseminated cutaneous leishmaniasis (BDCLDTH±), anergic diffuse cutaneous leishmaniasis (ADCLDTH-), and mucosal leishmaniasis (MLDTH++++). It has recently been demonstrated, however, that while L. (V.) braziliensis shows a clear potential to advance the infection from central LCL (a moderate T-cell hypersensitivity form) towards ML (the highest T-cell hypersensitivity pole), L...
2018: PloS One
https://www.readbyqxmd.com/read/29530633/chicken-immune-response-following-in-ovo-delivery-of-bacterial-flagellin
#17
M M Vaezirad, M G Koene, J A Wagenaar, J P M van Putten
In ovo immunization of chicken embryos with live vaccines is an effective strategy to protect chickens against several viral pathogens. We investigated the immune response of chicken embryos to purified recombinant protein. In ovo delivery of Salmonella flagellin to 18-day old embryonated eggs resulted in elevated pro-inflammatory chIL-6 and chIL-8 (CXCL8-CXCLi2) cytokine transcript levels in the intestine but not in the spleen at 24 h post-injection. Analysis of the chicken Toll-like receptor (TLR) repertoire in 19-day old embryos revealed gene transcripts in intestinal and spleen tissue for most chicken TLRs, including TLR5 which recognizes Salmonella flagellin (FliC)...
April 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29500532/evolutionary-divergence-of-tnl-disease-resistant-proteins-in-soybean-glycine-max-and-common-bean-phaseolus-vulgaris
#18
Surendra Neupane, Qin Ma, Febina M Mathew, Adam J Varenhorst, Ethan J Andersen, Madhav P Nepal
Disease-resistant genes (R genes) encode proteins that are involved in protecting plants from their pathogens and pests. Availability of complete genome sequences from soybean and common bean allowed us to perform a genome-wide identification and analysis of the Toll interleukin-1 receptor-like nucleotide-binding site leucine-rich repeat (TNL) proteins. Hidden Markov model (HMM) profiling of all protein sequences resulted in the identification of 117 and 77 regular TNL genes in soybean and common bean, respectively...
March 2, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29462003/toll-like-receptor-4-signaling-licenses-the-cytosolic-transport-of-lipopolysaccharide-from-bacterial-outer-membrane-vesicles
#19
Lan Gu, Ran Meng, Yiting Tang, Kai Zhao, Fang Liang, Rui Zhang, Qianqian Xue, Fangping Chen, Xianzhong Xiao, Huadong Wang, Haichao Wang, Timothy R Billiar, Ben Lu
Outer membrane vesicles (OMVs), released by variety of bacteria, are membrane-enclosed entities enriched in microbial components, toxins and virulent factors. OMVs could deliver lipopolysaccharide (LPS) into the cytosol of host cells and subsequently activate caspase-11, which critically orchestrates immune responses and mediates septic shock. Though it is known that caspase-11 is activated by intracellular LPS, how OMVs deliver LPS into the cytosol remains largely unknown. Here we show that the activation of toll like receptor 4 (TLR4), a LPS receptor on the cytoplasmic membrane, licenses macrophages to transport LPS from OMVs into the cytosol through TIR domain-containing adaptor-inducing interferon-β (TRIF)...
February 16, 2018: Shock
https://www.readbyqxmd.com/read/29461969/toll-like-receptor-expression-induced-by-exercise-in-obesity-and-metabolic-syndrome-a-systematic-review
#20
Isabel Rada, Louise Deldicque, Marc Francaux, Hermann Zbinden-Foncea
BACKGROUND: Obesity and metabolic syndrome are disorders that correlate with the activation of pro-inflammatory pathways and cytokine production, to which Toll like receptors (TLR) contribute. Exercise may act as an anti-inflammatory modulator, but there is no consensus about the role of the TLR in this tuning. The present styudy aims to systematically review the current evidence on exercise-induced TLR regulation in animals and humans suffering from obesity and metabolic syndrome. METHODS: Pubmed and Scopus databases were searched for publications from 1990 to September 2015...
2018: Exercise Immunology Review
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