Yaping Zhang, Leying Jiang, Siyong Huang, Chenshan Lian, Huiting Liang, Yun Xing, Jianbo Liu, Xiaojing Tian, Zhihong Liu, Rui Wang, Yuhao An, Fei Lu, Youdong Pan, Wei Han, Zigang Li, Feng Yin
Neoantigen peptides hold great potential as vaccine candidates for tumor immunotherapy. However, due to the limitation of antigen cellular uptake and cross-presentation, the progress with neoantigen peptide-based vaccines has obviously lagged in clinical trials. Here, a stapling peptide-based nano-vaccine is developed, comprising a self-assembly nanoparticle driven by the nucleic acid adjuvant-antigen conjugate. This nano-vaccine stimulates a strong tumor-specific T cell response by activating antigen presentation and toll-like receptor signaling pathways...
April 11, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)