keyword
https://read.qxmd.com/read/38543907/abundance-of-selected-lipopolysaccharide-rich-bacteria-and-levels-of-toll-like-receptor-4-and-interleukin-8-expression-are-significantly-associated-with-live-attenuated-rotavirus-vaccine-shedding-among-south-african-infants
#1
JOURNAL ARTICLE
Lerato P Kgosana, Mapaseka L Seheri, Cliff A Magwira
Bacterial lipopolysaccharides (LPSs) have been shown to promote enteric viral infections. This study tested the hypothesis that elevated levels of bacterial LPS improve oral rotavirus vaccine replication in South African infants. Stool samples were collected from infants a week after rotavirus vaccination to identify vaccine virus shedders ( n = 43) and non-shedders ( n = 35). Quantitative real-time PCR was used to assay for selected LPS-rich bacteria, including Serratia marcescens , Pseudomonas aeruguinosa and Klebsiella pneumonia , and to measure the gene expression of bacterial LPS, host Toll-like Receptor 4 (TLR4) and Interleukin-8 (IL-8)...
March 5, 2024: Vaccines
https://read.qxmd.com/read/38542287/vesicular-messages-from-dental-biofilms-for-neutrophils
#2
JOURNAL ARTICLE
Ljubomir Vitkov, Jelena Krunić, Johanna Dudek, Madhusudhan Reddy Bobbili, Johannes Grillari, Bernhard Hausegger, Irena Mladenović, Nikola Stojanović, Wolf Dietrich Krautgartner, Hannah Oberthaler, Christine Schauer, Martin Herrmann, Jeeshan Singh, Bernd Minnich, Matthias Hannig
The encounter between dental biofilm and neutrophils in periodontitis remains elusive, although it apparently plays a crucial role in the periodontal pathology and constitutes a key topic of periodontology. Dental biofilm and neutrophils were isolated from orally healthy persons and patients with periodontitis. We investigated biofilm and its particle-shedding phenomenon with electron microscopy and nanoparticle tracking analysis (NTA); biofilm shedding-neutrophil interactions were examined ex vivo with epi-fluorescence microscopy...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38532461/placental-tlr-recognition-of-salivary-and-subgingival-microbiota-is-associated-with-pregnancy-complications
#3
JOURNAL ARTICLE
Kazune Pax, Nurcan Buduneli, Murat Alan, Pinar Meric, Onder Gurlek, Shareef M Dabdoub, Purnima S Kumar
BACKGROUND: Pre-term birth, the leading cause of neonatal mortality, has been associated with maternal periodontal disease and the presence of oral pathogens in the placenta. However, the mechanisms that underpin this link are not known. This investigation aimed to identify the origins of placental microbiota and to interrogate the association between parturition complications and immune recognition of placental microbial motifs. Video Abstract METHODS: Saliva, plaque, serum, and placenta were collected during 130 full-term (FT), pre-term (PT), or pre-term complicated by pre-eclampsia (PTPE) deliveries and subjected to whole-genome shotgun sequencing...
March 26, 2024: Microbiome
https://read.qxmd.com/read/38504163/probiotics-ameliorate-endocrine-disorders-via-modulating-inflammatory-pathways-a-systematic-review
#4
REVIEW
Marzieh Nemati, Bahareh Ebrahimi, Nima Montazeri-Najafabady
Probiotics has offered a new prospect to treat and manage a variety of endocrine disorders such as obesity, diabetes, non- alcoholic fatty liver disease and metabolic syndrome. The precise mechanisms by which probiotics exert their beneficial effects on endocrine disorders and its associated problems are still indecisive. It seems that regulating the immune system and suppressing pro-inflammatory pathways like tumor necrosis factor-α and interleukin-6 or triggering anti-inflammatory pathways like interleukin-4 and 10 may be one of the potential mechanisms in the managing of endocrine disorders...
March 19, 2024: Genes & Nutrition
https://read.qxmd.com/read/38501503/fortunellin-ameliorates-lps-induced-acute-lung-injury-inflammation-and-collagen-deposition-by-restraining-the-tlr4-nf-%C3%AE%C2%BAb-nlrp3-pathway
#5
JOURNAL ARTICLE
Danjuan Liu, Rongjie Guo, Bingbing Shi, Min Chen, Shuoyun Weng, Junting Weng
OBJECTIVE: Acute lung injury (ALI) is the prevalent respiratory disease of acute inflammation with high morbidity and mortality. Fortunellin has anti-inflammation property, but its role in ALI remains elusive. Thus, this study clarified the function of fortunellin on ALI pathogenesis. METHODS: The ALI mouse model was established by lipopolysaccharide (LPS) induction, and lung tissue damage was evaluated utilizing hematoxylin-eosin (HE) staining. The edema of lung tissue was measured by the lung wet/dry (W/D) ratio...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38488815/rintatolimod-in-advanced-pancreatic-cancer-enhances-anti-tumor-immunity-through-dendritic-cell-mediated-t-cell-responses
#6
JOURNAL ARTICLE
Casper W F van Eijck, Hassana El Haddaoui, Songul Kucukcelebi, Disha Vadgama, Amine Fellah, Dana A M Mustafa, Joachim G J V Aerts, Casper H J van Eijck, Marcella Willemsen
PURPOSE: Amid the need for new approaches to improve survival in pancreatic ductal adenocarcinoma (PDAC), immune-based therapies have garnered interest. Rintatolimod, a toll-like receptor 3 (TLR-3) agonist, is a potential candidate due to its dual impact on restraining PDAC cell functions and boosting the anti-tumor immune response. This study investigates the effect of TLR-3 activation through rintatolimod on the peripheral immune landscape of advanced PDAC patients. PATIENTS AND METHODS: Paired blood samples of 30 patients with advanced PDAC, collected at baseline and after 12 rintatolimod intravenous infusions, underwent comprehensive transcriptomic NanoString and proteomic flow cytometry profiling...
March 15, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38486475/a-novel-immunoinformatics-approach-for-developing-a-poly-epitope-vaccine-targeting-foot-and-mouth-disease-virus-exploiting-structural-vp-proteins
#7
JOURNAL ARTICLE
Muhammad Saad Bhutta, Muhammad Awais, Sahar Sadaqat, Fernando Berton Zanchi, Naila Shahid, Abdul Qayyum Rao
Foot and mouth Disease virus (FMDV) belongs to Picornaviridae family and Aphthovirus genus causing Foot and mouth disease (FMD) in cloven-hoofed animals. FMDV, a prevalent virus induces both acute and chronic infections with high mutation rates resulting in seven primary serotypes, making vaccine development indispensable. Due to time and cost effectiveness of the immunoinformatic approach, we designed in-silico polyepitope vaccine (PEV) for the curtailment of FMDV. Structural and immunogenic parts of FMDV (Viral Protein 1 (VP1), Viral Protein 2 (VP2), Viral Protein 3 (VP3), and Viral Protein 4 (VP4)) were used to design the cytotoxic T Lymphocyte (CTL), Helper T Lymphocyte (HTL), and B-cell epitopes, followed by screening for antigenic, non-allergenic, Interferon (IFN) simulator, and non-toxicity, which narrowed down to 7 CTL, 3 HTL, and 12 B-cell epitopes...
March 15, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38483447/tlr2-regulates-hair-follicle-cycle-and-regeneration-via-bmp-signaling
#8
JOURNAL ARTICLE
Luyang Xiong, Irina Zhevlakova, Xiaoxia Z West, Detao Gao, Rakhilya Murtazina, Anthony Horak, J Mark Brown, Iuliia Molokotina, Eugene A Podrez, Tatiana V Byzova
The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis of aging hair follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance of hair follicle homeostasis and the regeneration capacity after damage depend on TLR2 in hair follicle stem cells (HFSCs). In healthy hair follicles, TLR2 is expressed in a cycle-dependent manner and governs HFSCs activation by countering inhibitory BMP signaling...
March 14, 2024: ELife
https://read.qxmd.com/read/38478694/a-type-i-interferon-regulatory-network-for-human-plasmacytoid-dendritic-cells-based-on-heparin-membrane-bound-and-soluble-bdca-2
#9
JOURNAL ARTICLE
Francisco Venegas-Solis, Laura Staliunaite, Elisa Rudolph, Carina Chan-Song Münch, Philipp Yu, Sven-A Freibert, Takahiro Maeda, Christine L Zimmer, Christian Möbs, Christian Keller, Andreas Kaufmann, Stefan Bauer
Plasmacytoid dendritic cells (pDCs) produce type I interferons (IFNs) after sensing viral/bacterial RNA or DNA by toll-like receptor (TLR) 7 or TLR9, respectively. However, aberrant pDCs activation can cause adverse effects on the host and contributes to the pathogenesis of type I IFN-related autoimmune diseases. Here, we show that heparin interacts with the human pDCs-specific blood dendritic cell antigen 2 (BDCA-2) but not with related lectins such as DCIR or dectin-2. Importantly, BDCA-2-heparin interaction depends on heparin sulfation and receptor glycosylation and results in inhibition of TLR9-driven type I IFN production in primary human pDCs and the pDC-like cell line CAL-1...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38463226/prognostic-and-clinicopathological-significance-of-tlr4-expression-in-patients-with-breast-cancer-a-meta-analysis
#10
REVIEW
Jinxu Wen, Jiayi Zhang, Xiaoyong Wu, Xuemin Yan, Xiaoru Qin, Yuexin Wang
BACKGROUND: The prognostic value of Toll-like receptor 4 (TLR4) in breast cancer remains to be determined. Therefore, this paper aims to conduct a meta-analysis to assess the correlation between TLR4 and clinicopathological indicators as well as survival outcomes in breast cancer. METHOD: Related literature retrieved from Embase, PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI) and China Wanfang. The search deadline is April 12, 2023...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38458969/saikosaponin-d-mitigate-pilocarpine-induced-astrocyte-injury-by-regulating-the-nlrp3-caspase-1-signaling-pathway
#11
JOURNAL ARTICLE
Jun-Yan Liu, Yu-Ling Shen, Jing-Yi Zhu, Dong-Dong Yang
Studies have shown that saikosaponin D (SSD) has favorable neurotherapeutic effects. Therefore, the objective of this study was to explore the efficacy and possible molecular mechanisms of SSD on pilocarpine (PP)-induced astrocyte injury. Primary astrocytes were isolated from juvenile rats and identified using immunofluorescence. The cells were treated with PP and/or SSD for 6 h and 12 h, respectively, followed by measurement of their viability through 3-(4,5-dimethylthiazol)-2,5-diphenyl-tetrazolium bromide (MTT) assay...
March 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/38454980/the-role-of-mediator-suppressor-of-cytokine-signaling-socs-toll-like-receptor-3-tlr-3-and-nuclear-factor-kappa-b-nf%C3%AE%C2%BAb-on-cytokine-production-during-dengue-virus-infection
#12
JOURNAL ARTICLE
Sri Masyeni, Kuntaman Kuntaman, Aryati Aryati, Muchlis Au Sofro, Usman Hadi, Gondo Mastutik, Windu Purnomo, Agus Santosa, Muhammad Iqhrammullah, Benediktus Yohan, Erni J Nelwan, R Tedjo Sasmono
Inability to understand the pathogenesis of severe dengue, in particular the control mechanism of immune responses, has led to high mortality rate for patients with dengue shock syndrome (DSS). The aim of this study was to determine the control mechanism of cytokine production by mediator suppressor of cytokine signaling (SOCS), toll-like receptor 3 (TLR-3) and nuclear factor kappa B (NFκB) during DENV infection. Peripheral blood mononuclear blood cells (PBMC), isolated from healthy individuals, were infected with dengue virus (DENV)-2 strain SJN-006 Cosmopolitan genotype (isolated from Bali, Indonesia)...
August 2023: Narra J
https://read.qxmd.com/read/38442474/chlorogenic-acid-ameliorates-intestinal-inflammation-by-inhibiting-nf-%C3%AE%C2%BAb-and-endoplasmic-reticulum-stress-in-lipopolysaccharide-challenged-broilers
#13
JOURNAL ARTICLE
Huawei Liu, Hongling Meng, Mengmeng Du, Huimin Lv, Yang Wang, Kai Zhang
Intestinal inflammation is a primary contributor to poor growth performance during poultry production. Chlorogenic acid (CGA) is a natural phenolic acid that exhibits superior anti-inflammatory activity and improved intestinal health. To investigate the protective effects and molecular mechanisms of CGA during intestinal inflammation in lipopolysaccharide (LPS)-challenged broilers, we randomly divided 288 one-day-old male Cobb broilers into 4 groups: a control group fed a basal diet (CON group), a basal diet + LPS group (LPS group), and 2 basal diet groups fed 500 or 750 mg/kg CGA + LPS (CGA_500 or CGA_750 groups)...
February 24, 2024: Poultry Science
https://read.qxmd.com/read/38424363/immune-microenvironment-heterogeneity-of-concurrent-adenocarcinoma-and-squamous-cell-carcinoma-in-multiple-primary-lung-cancers
#14
JOURNAL ARTICLE
Jiahao Zhang, Yiheng Huang, Yichao Han, Dong Dong, Yuqin Cao, Xiang Chen, Di Liu, Xueyan Cheng, Debin Sun, Hecheng Li, Yajie Zhang
The molecular profiles and tumor immune microenvironment (TIME) of multiple primary lung cancers (MPLCs) presenting as concurrent lung adenocarcinoma (ADC) and squamous cell carcinoma (SQCC) remain unknown. We aimed to clarify these factors. We performed whole-exome sequencing (WES), RNA sequencing (RNA-Seq), and multiplex immunohistochemistry (mIHC) for five patients with concurrent ADC and SQCC. We found the genetic mutations were similar between ADC and SQCC groups. RNA-Seq revealed that the gene expression and pathways enriched in ADC and SQCC groups were quite different...
February 29, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38414294/hmgb1-regulates-th17-cell-differentiation-and-function-in-patients-with-psoriasis
#15
JOURNAL ARTICLE
Xiaofeng Zhu, Yue Dou, Yawen Lin, Gaoping Chu, Jing Wang, Lei Ma
BACKGROUND: Psoriasis is an immune-mediated chronic inflammatory skin disease, in which T helper 17 (Th17) cells and its effective cytokine interleukin (IL)-17A play a pivotal pathogenic role. High mobility group box 1 (HMGB1) is an important proinflammatory cytokine, which has been confirmed to be highly expressed in the peripheral circulation and epidermis tissues of psoriasis patients. The regulatory effect of HMGB1 on IL-17A expression and function has been reported in some inflammatory and autoimmune diseases by the HMGB1-Toll-like receptor 4 (TLR4)-interleukin (IL)-23-IL-17A pathway...
February 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38407762/polymorphisms-in-innate-and-adaptive-immune-genes-in-subjects-with-allergic-bronchopulmonary-aspergillosis-complicating-asthma
#16
JOURNAL ARTICLE
Rimjhim Kanaujia, Amit Arora, Arunaloke Chakrabarti, Shivaprakash M Rudramurthy, Ritesh Agarwal
Innate and adaptive immunity play a crucial role in allergic bronchopulmonary aspergillosis (ABPA) pathogenesis. We performed next-generation sequencing using the Illumina TruSight One panel (4,811 human disease-associated genes, at least 20 × coverage) and selected 22 known immune genes (toll-like receptors (TLRs), C-type lectin, interleukin-4 receptor, and others). We included ABPA (n = 18), asthma without ABPA (n = 12), and healthy controls (n = 8)...
February 26, 2024: Mycopathologia
https://read.qxmd.com/read/38407083/investigation-of-correlation-between-resistance-to-diazepam-and-expression-of-inflammatory-markers-in-the-peripheral-blood-of-patients-with-status-epilepticus
#17
JOURNAL ARTICLE
Corry Novita Mahama, Melva Louisa, Fitri Octaviana, Dwi Anita Suryandari, Astri Budikayanti, Heri Wibowo
OBJECTIVE: This study investigated several inflammatory markers' gene and protein expression in status epilepticus (SE) and their correlation with diazepam resistance. MATERIALS AND METHODS: Peripheral blood samples were collected from 18 adult patients with SE in Cipto Mangunkusumo Central Hospital, consisting of 12 diazepam-responsive and six diazepam-resistant samples, within 72 hours of the onset of the seizure. We collected baseline demographic and clinical data from each subject...
December 2023: Acta Medica Academica
https://read.qxmd.com/read/38400192/serum-sarm1-levels-and-diabetic-peripheral-neuropathy-in-type-2-diabetes-correlation-with-clinical-neuropathy-scales-and-nerve-conduction-studies-and-impact-of-covid-19-vaccination
#18
JOURNAL ARTICLE
Moafaq S Alrawaili, Ahmad R Abuzinadah, Aysha A AlShareef, Emad A Hindi, Ahmed K Bamaga, Weam Alshora, Hashim Sindi
Patients with peripheral neuropathy with type 2 diabetes mellitus (T2DM) are more likely to have functional impairments. Recently, the gene for serum sterile alpha and toll/interleukin receptor motif-containing protein 1 (SARM1), which may contribute to the pathogenesis of Wallerian degeneration, was discovered in mice models of peripheral neuropathy. We set out to assess serum SARM1's activity as a potential biomarker for the early identification of diabetic peripheral neuropathy in T2DM patients while also examining the impact of the COVID-19 vaccine on SARM1 levels...
February 17, 2024: Vaccines
https://read.qxmd.com/read/38400099/adjuvanted-vaccine-induces-functional-antibodies-against-pseudomonas-aeruginosa-filamentous-bacteriophages
#19
JOURNAL ARTICLE
Valery C Román-Cruz, Shannon M Miller, Roman A Schoener, Chase Lukasiewicz, Amelia K Schmidt, Blair L DeBuysscher, David Burkhart, Patrick R Secor, Jay T Evans
Pseudomonas aeruginosa ( Pa ), a WHO priority 1 pathogen, resulted in approximately 559,000 deaths globally in 2019. Pa has a multitude of host-immune evasion strategies that enhance Pa virulence. Most clinical isolates of Pa are infected by a phage called Pf that has the ability to misdirect the host-immune response and provide structural integrity to biofilms. Previous studies demonstrate that vaccination against the coat protein (CoaB) of Pf4 virions can assist in the clearance of Pa from the dorsal wound model in mice...
January 24, 2024: Vaccines
https://read.qxmd.com/read/38398037/proteolytic-vesicles-derived-from-salmonella-enterica-serovar-typhimurium-infected-macrophages-enhancing-mmp-9-mediated-invasion-and-ev-accumulation
#20
JOURNAL ARTICLE
Alon Nudelman, Anjana Shenoy, Hyla Allouche-Arnon, Michal Fisler, Irit Rosenhek-Goldian, Lior Dayan, Paula Abou Karam, Ziv Porat, Inna Solomonov, Neta Regev-Rudzki, Amnon Bar-Shir, Irit Sagi
Proteolysis of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) plays a crucial role in the immune response to bacterial infections. Here we report the secretion of MMPs associated with proteolytic extracellular vesicles (EVs) released by macrophages in response to Salmonella enterica serovar Typhimurium infection. Specifically, we used global proteomics, in vitro, and in vivo approaches to investigate the composition and function of these proteolytic EVs. Using a model of S. Typhimurium infection in murine macrophages, we isolated and characterized a population of small EVs...
February 15, 2024: Biomedicines
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