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toll like receptor 12

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https://www.readbyqxmd.com/read/28202909/leukocyte-tlr5-deficiency-inhibits-atherosclerosis-by-reduced-macrophage-recruitment-and-defective-t-cell-responsiveness
#1
Guilielmus H J M Ellenbroek, Gijs H M van Puijvelde, Adam A Anas, Martine Bot, Miriam Asbach, Arjan Schoneveld, Peter J van Santbrink, Amanda C Foks, Leo Timmers, Pieter A Doevendans, Gerard Pasterkamp, Imo E Hoefer, Tom van der Poll, Johan Kuiper, Saskia C A de Jager
Toll-like receptors (TLR) provide a critical link between innate and adaptive immunity, both important players in atherosclerosis. Since evidence for the role of TLR5 is lacking, we aimed to establish this in the immune axis of atherosclerosis. We assessed the effect of the TLR5-specific ligand Flagellin on macrophage maturation and T-cell polarisation. Next, we generated TLR5(-/-)LDLr(-/-) chimeras to study the effect of hematopoietic TLR5 deficiency on atherosclerosis formation. Flagellin stimulation did not influence wildtype or TLR5(-/-) macrophage maturation...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28191009/defective-il-23-il-17-axis-protects-p47phox-mice-from-colon-cancer
#2
Cornelia Richter, Martina Herrero San Juan, Benno Weigmann, Dominik Bergis, Katrin Dauber, Michael H Muders, Gustavo B Baretton, Josef Martin Pfeilschifter, Halvard Bonig, Sebastian Brenner, Heinfried H Radeke
In the colon, a sophisticated balance between immune reaction and tolerance is absolutely required. Dysfunction may lead to pathologic phenotypes ranging from chronic inflammatory processes to cancer development. Two prominent modulators of colon inflammation are represented by the closely related cytokines interleukin (IL)-12 and IL-23, which initiate adaptive Th1 and Th17 immune responses, respectively. In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28190517/calcium-mobilizing-treatment-acts-as-a-co-signal-for-tlr-mediated-induction-of-interleukin-12-il-12p70-secretion-by-murine-bone-marrow-derived-dendritic-cells
#3
Emily Huang, Loral Showalter, Shuwen Xu, Brian J Czernliecki, Gary K Koski
We sought to determine whether pharmacological calcium-mobilizing agents could act in cooperation with Toll-like receptor (TLR) signals to induce high-level IL-12 production from murine bone marrow-derived dendritic cells. We found that calcium mobilization alone induced no IL-12, yet dramatically enhanced IL-12p70 secretion elicited by TLR ligands. Enhanced IL-12 production induced by calcium ionophore plus single TLR ligands, but not through dual TLR ligands, was inhibited by the calcineurin antagonist cyclosporine A, suggesting divergent mechanisms of IL-12 induction...
February 1, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28190471/plant-lectins-conbr-and-cfl-modulate-expression-toll-like-receptors-pro-inflammatory-cytokines-and-reduce-the-bacterial-burden-in-macrophages-infected-with-salmonella-enterica-serovar-typhimurium
#4
Jec Batista, M T Ralph, R V Vaz, Pfc Souza, A B Silva, Dco Nascimento, L T Souza, M V Ramos, P Mastroeni, J V Lima-Filho
BACKGROUND: Plant lectins have long been used in biomedical research as immunomodulators against tumor cells and microbial infections. PURPOSE: To test the ability of plant lectins ConBr (Canavalia brasiliensis) and CFL (Cratylia argentea) to activate antimicrobial and immunomodulatory activities of murine peritoneal macrophages (pMØ) infected with a virulent strain of Salmonella enterica serovar Typhimurium (STm). METHODS: We incubated pMØ with non-toxic amounts of ConBr and CFL either before (preventive schedule) or after (curative schedule) exposure to STm...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28174321/time-course-effect-of-lps-on-tlrs-expression-and-steroidogenesis-in-the-goose-ovary
#5
ShiJia Ying, JiaJia Guo, ZiChun Dai, HuanXi Zhu, JianNing Yu, WeiMing Ma, JiaYI Li, Muhammad Faheem Akhtar, ZhenDan Shi
The ovary of Chinese goose is easily infected by microorganisms because of mating behaviour on water, which causes decreased laying performance. This study investigated the time course effect of lipopolysaccharide (LPS) on the steroidogenesis and mRNA expression of Toll-like receptors (TLRs), a class of key pattern recognition receptor, in the breeding goose ovary. The laying geese were treated intravenously with LPS for 0, 6, 12, 24 and 36 h, and all birds were slaughtered approximately 8 h after oviposition...
February 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28159691/studies-on-expression-pattern-of-toll-like-receptor-5-tlr5-in-edwardsiella-tarda-infected-pangasianodon-hypophthalmus
#6
Poojashree Kachigere Jayaramu, Gayatri Tripathi, A Pavan Kumar, Jeena Keezhedath, Mujahid Khan Pathan, Pani Prasad Kurcheti
TLR5 is one of the important PRR (pathogen recognition receptors) and plays a fundamental role in pathogen recognition and activation of innate immune responses. It recognizes bacterial flagellin and stimulates the production of proinflammatory cytokines, through signalling via the adaptor protein MyD88. In this study, we characterized partial TLR5 (soluble form) gene from Pangasianodon hypophthalmus and analysed its expression profile upon challenge by Edwardsiella tarda. Bioinformatic analysis of gene sequence revealed a putative protein of 266 amino acids with four Leucine rich repeats...
January 31, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28146629/identification-of-high-potency-human-tlr8-and-dual-tlr7-tlr8-agonists-in-pyrimidine-2-4-diamines
#7
Mallesh Beesu, Alex C D Salyer, Michael J H Brush, Kathryn L Trautman, Justin K Hill, Sunil A David
The induction of Toll-like receptor 7 (TLR7)-dependent Type I interferons (IFN-α/β) from plasmacytoid dendritic cells as well as the production of TLR8-dependent Type II interferon (IFN-γ), TNF-α, and IL-12 in myeloid dendritic cells are of importance in generating T helper-1 biased adaptive immune responses. In an effort to identify novel dual TLR7/TLR8-active compounds, we undertook structure-activity relationship studies in pyrimidine 2,4-diamines, focusing on substituents at C5. Several analogues substituted with aminopropyl appendages at C5 displayed dominant TLR8-agonistic activity...
February 1, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28139755/genetically-determined-high-activity-of-il-12-and-il-18-in-ulcerative-colitis-and-tlr5-in-crohns-disease-were-associated-with-non-response-to-anti-tnf-therapy
#8
S Bank, P S Andersen, J Burisch, N Pedersen, S Roug, J Galsgaard, S Y Turino, J B Brodersen, S Rashid, B K Rasmussen, S Avlund, T B Olesen, H J Hoffmann, B A Nexø, J Sode, U Vogel, V Andersen
Anti-tumour necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment. A recent study indicated that genetically determined high activity of pro-inflammatory cytokines, including interleukin-1β (IL-1β), IL-6 and interferon gamma (IFN-γ), are associated with non-response to anti-TNF therapy. Using a candidate gene approach, 21 functional single-nucleotide polymorphisms (SNPs) in 14 genes in the Toll-like receptors, the inflammasome and the IFNG pathways were assessed in 482 and 256 prior anti-TNF naïve Danish patients with CD and UC, respectively...
January 31, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28123321/in%C3%A2-vitro-antioxidative-and-anti-inflammatory-effects-of-the-compound-k-rich-fraction-biogf1k-prepared-from-panax-ginseng
#9
Muhammad Jahangir Hossen, Yong Deog Hong, Kwang-Soo Baek, Sulgi Yoo, Yo Han Hong, Ji Hye Kim, Jeong-Oog Lee, Donghyun Kim, Junseong Park, Jae Youl Cho
BACKGROUND: BIOGF1K, a compound K-rich fraction prepared from the root of Panax ginseng, is widely used for cosmetic purposes in Korea. We investigated the functional mechanisms of the anti-inflammatory and antioxidative activities of BIOGF1K by discovering target enzymes through various molecular studies. METHODS: We explored the inhibitory mechanisms of BIOGF1K using lipopolysaccharide-mediated inflammatory responses, reporter gene assays involving overexpression of toll-like receptor adaptor molecules, and immunoblotting analysis...
January 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28114604/topical-imiquimod-plus-nab-paclitaxel-for-breast-cancer-cutaneous-metastases-a-phase-2-clinical-trial
#10
Lupe G Salazar, Hailing Lu, Jessica L Reichow, Jennifer S Childs, Andrew L Coveler, Doreen M Higgins, James Waisman, Kimberly H Allison, Yushe Dang, Mary L Disis
Importance: Salvage chemotherapy for recurrent chest wall lesions in breast cancer results in response rates of 20% to 30%. Preclinical studies showed significant disease regression could be induced in murine chest wall mammary cancers with a topical toll-like receptor (TLR)-7 agonist, imiquimod. Objective: To evaluate the safety and objective response rate (ORR) of imiquimod in combination with systemic albumin bound paclitaxel in treatment-refractory breast cancer of the chest wall...
January 19, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28110064/activation-of-dendritic-cells-by-low-molecular-weight-oyster-polysaccharides
#11
Ming Zhong, Cheng Zhong, Tingting Wang, Pei Hu, Guanghui Wang, Rujing Ren, Jing Zhang, Huijei Gao, Wen Cui, Wenjuan Duan, Jiantu Che
Dendritic cells play a primary role in antigen presentation to CD4(+) T cells, which initiate acquired immune responses. Therefore, determining positive modulators of dendritic cell activation to improve therapeutic approaches for cancer treatment might be useful. We here investigated the effects of low molecular weight oyster polysaccharides (LMW-OPS) on bone marrow-derived dendritic cells (BMDCs) obtained from mice. LMW-OPS increased the surface expression of major histocompatibility complex class II (MHC-II), CD40 and CD86 in BMDCs and induced the secretion of tumour necrosis factor (TNF)-α and interleukin (IL)-12, which were significantly decreased in the BMDCs derived from MyD88(-/-) mice but not from the lipopolysaccharide-resistant C3H/HeJ mice...
January 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28087537/effects-of-lactobacillus-plantarum-oll2712-culture-conditions-on-the-anti-inflammatory-activity-for-murine-immune-cells-and-obese-and-type-2-diabetic-mice
#12
T Toshimitsu, S Ozaki, J Mochizuki, K Furuichi, Y Asami
: Studies on the health-promoting effects of lactic acid bacteria (LAB) are numerous, but few provide examples of the relationship between LAB function and culture conditions. We verified the effect of differences in culture conditions on Lactobacillus plantarum OLL2712 (OLL2712) functionality; this strain exhibits anti-inflammatory activity and preventive effects against metabolic disorders. We measured IL-10 and IL-12 production in murine immune cells treated with OLL2712 cells prepared under various culture conditions...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28069432/microrna-expression-changes-after-lipopolysaccharide-treatment-in-gills-of-amphioxus-branchiostoma-belcheri
#13
Xin Liao, Liu Yang, Qilin Zhang, Junyuan Chen
Recently, amphioxus has served as a model for studying the origin and evolution of vertebrate immunity. However, little is known about how microRNAs (miRNAs) are involved in the immune defense in amphioxus. In this article, we identified the amphioxus miRNAs in the acute-phase response to lipopolysaccharide (LPS). We determined the time point for the peak of immune response in amphioxus after LPS challenge by evaluating the expression of Branchiostoma belcheri toll-like receptor 1, NF-κb (c-Rel), and big defensin which react with pathogen-associated molecular patterns(PAMPs)...
January 6, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28049238/the-curves-exercise-suppresses-endotoxemia-in-korean-women-with-obesity
#14
Seon Ah Jin, Sun Kyeong Kim, Hee Jung Seo, Mijoo Kim, Kye Taek Ahn, Jun Hyung Kim, Jae Hyeong Park, Jae Hwan Lee, Si Wan Choi, Jin Ok Jeong
Obesity and metabolic syndrome is a worldwide pandemic and associated with high cardiovascular risk. Metabolic endotoxemia (ME) is thought to be an underlying molecular mechanism. It triggers toll-like receptor 4-mediated inflammatory adipokines and causes a chronic low grade inflammatory status, which results in cardiovascular risk increase. Exercise is the best nonpharmacological treatment to improve prognosis. In this study, we examined the circulating endotoxin level in Korean obese women and investigated effects of exercise on it...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28038359/green-tea-extract-treatment-reduces-nf%C3%AE%C2%BAb-activation-in-mice-with-diet-induced-nonalcoholic-steatohepatitis-by-lowering-tnfr1-and-tlr4-expression-and-ligand-availability
#15
Jinhui Li, Teryn N Sapper, Eunice Mah, Meredith V Moller, Joshua B Kim, Chureeporn Chitchumroonchokchai, Joshua D McDonald, Richard S Bruno
NFκB-mediated inflammation contributes to liver injury during nonalcoholic steatohepatitis (NASH). We hypothesized that antiinflammatory activities of green tea extract (GTE) during NASH would lower tumor necrosis factor receptor-1 (TNFR1)- and Toll-like receptor-4 (TLR4)-mediated NFκB activation. Male C57BL6/J mice (6 weeks old) were fed a low-fat (LF) or high-fat (HF) diet for 12 weeks to induce NASH. They were then randomized to continue on these diets supplemented with 0 or 2% GTE (n=10/group) for an additional 8 weeks prior to evaluating NASH, NFκB inflammation and TNFR1 and TLR4 receptor complexes and their respective ligands, TNFα and endotoxin...
December 21, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28035483/chlamydia-pneumoniae-induces-interleukin-12-responses-in-peripheral-blood-mononuclear-cells-in-asthma-and-the-role-of-toll-like-receptor-2-versus-4-a-pilot-study
#16
T A Smith-Norowitz, J Perlman, Y M Norowitz, R Joks, H G Durkin, M R Hammerschlag, S Kohlhoff
BACKGROUND: Chlamydia pneumoniae causes respiratory infection in adults and children, and has been associated with asthma exacerbations and induction of Immunoglobulin (Ig) E responses. We previously reported that C. pneumoniae enhances T helper (Th) 2 responses of peripheral blood mononuclear cells (PBMC) from asthmatic patients. It is likely that toll like receptor (TLR)-2 and TLR-4 mediate cytokine responses and host defense against C. pneumoniae. Thus, we sought to determine whether engagement of TLR-2 or TLR-4 may induce IL-12 production in our C...
December 29, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28028951/increased-expression-of-tlr4-and-tlr7-but-not-prolactin-mrna-by-peripheral-blood-monocytes-in-active-celiac-disease
#17
Iva Brynychova, Iva Hoffmanova, Milos Dvorak, Pavlina Dankova
BACKGROUND: Celiac disease (CD) is an organ-specific autoimmune disease, and both adaptive and innate immunity are involved in its development. OBJECTIVES: The aim of the study was to determine whether the markers of intestinal mucosal inflammation in CD can be detected in peripheral blood monocytes (PBMs), and whether the immune properties of PBMs change as the clinical signs and symptoms of CD improve after the introduction of a gluten-free diet (GFD). The focus was on changes in mRNA expression of selected toll-like receptors (TLR2, TLR4, TLR7), stress cytokine prolactin (PRL), and proand anti-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-10) in PBMs...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28025440/toll-like-receptor-4-polymorphism-is-associated-with-increased-susceptibility-to-chronic-obstructive-pulmonary-disease-in-han-chinese-patients-with-chronic-periodontitis
#18
Hui Yu, Mei Lin, Xuejin Wang, Songling Wang, Zuomin Wang
The aim of the present study was to evaluate the association of single nucleotide polymorphisms (SNPs) in toll-like receptor 4 (TLR4) with chronic obstructive pulmonary disease (COPD) in Han Chinese patients with chronic periodontitis (CP). Six candidate SNPs of TLR4-rs10759930, rs10983755, rs11536879, rs1927907, rs11536889 and rs7873784-and 18 haplotype-tagging SNPs (tagSNPs) were genotyped in 339 patients with chronic periodontitis only (CP group), and 373 CP patients with COPD (CP with COPD group). The genotype distribution and allele frequencies of TLR4 rs1927907 among the CP (AA: 26, 8...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28013190/mycobacterium-indicus-pranii-mw-mediated-protection-against-visceral-leishmaniasis-by-reciprocal-regulation-of-host-dual-specificity-phosphatases
#19
Shabina Parveen, Syamdas Bandhyopadhyay, Sonali Das, Suchandra Bhattacharyya Majumdar, Junaid Jibran Jawed, Bidisha Paul Chowdhury, Bhaskar Saha, Subrata Majumdar
Leishmania donovani resides within the host macrophages by dampening host defence mechanisms and thereby it modulates the host cell functions for its survival. Multiple host cell factors compete during the interplay between the host and the parasite. Roles for dual-specificity phosphatases (DUSPs) are implicated in various pathological conditions. However, the reciprocity of these DUSPs was unknown in L. donovani infection in a susceptible model. Here, we show that Mycobacterium indicus pranii (Mw), an immunomodulator, reciprocally regulates DUSP1 and DUSP6 through the TLR4 pathway...
December 2016: International Immunology
https://www.readbyqxmd.com/read/28007141/genetic-and-pharmacological-inhibition-of-trem-1-limits-the-development-of-experimental-atherosclerosis
#20
Jeremie Joffre, Stephane Potteaux, Lynda Zeboudj, Xavier Loyer, Amir Boufenzer, Ludivine Laurans, Bruno Esposito, Marie Vandestienne, Saskia C A de Jager, Carole Hénique, Ivana Zlatanova, Soraya Taleb, Patrick Bruneval, Alain Tedgui, Ziad Mallat, Sebastien Gibot, Hafid Ait-Oufella
BACKGROUND: Innate immune responses activated through myeloid cells contribute to the initiation, progression, and complications of atherosclerosis in experimental models. However, the critical upstream pathways that link innate immune activation to foam cell formation are still poorly identified. OBJECTIVES: This study sought to investigate the hypothesis that activation of the triggering receptor expressed on myeloid cells (TREM-1) plays a determinant role in macrophage atherogenic responses...
December 27, 2016: Journal of the American College of Cardiology
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