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https://www.readbyqxmd.com/read/29036406/effects-of-computerized-decision-support-system-implementations-on-patient-outcomes-in-inpatient-care-a-systematic-review
#1
Julian Varghese, Maren Kleine, Sophia Isabella Gessner, Sarah Sandmann, Martin Dugas
Objectives: To systematically classify the clinical impact of computerized clinical decision support systems (CDSSs) in inpatient care. Materials and Methods: Medline, Cochrane Trials, and Cochrane Reviews were searched for CDSS studies that assessed patient outcomes in inpatient settings. For each study, 2 physicians independently mapped patient outcome effects to a predefined medical effect score to assess the clinical impact of reported outcome effects. Disagreements were measured by using weighted kappa and solved by consensus...
September 23, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29036270/on-expert-curation-and-scalability-uniprotkb-swiss-prot-as-a-case-study
#2
Sylvain Poux, Cecilia N Arighi, Michele Magrane, Alex Bateman, Chih-Hsuan Wei, Zhiyong Lu, Emmanuel Boutet, Hema Bye-A-Jee, Maria Livia Famiglietti, Bernd Roechert
Motivation: Biological knowledgebases, such as UniProtKB/Swiss-Prot, constitute an essential component of daily scientific research by offering distilled, summarized and computable knowledge extracted from the literature by expert curators. While knowledgebases play an increasingly important role in the scientific community, their ability to keep up with the growth of biomedical literature is under scrutiny. Using UniProtKB/Swiss-Prot as a case study, we address this concern via multiple literature triage approaches...
July 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29035648/treatment-of-mandibular-osteomyelitis-in-two-red-necked-wallabies-macropus-rufogriseus-by-means-of-intensive-long-term-parenteral-drug-administration-and-serial-computed-tomographic-monitoring
#3
Lauren P Kane, Jennifer N Langan, Michael J Adkesson, Sathya K Chinnadurai, Benjamin N Nevitt, Randi Drees
CASE DESCRIPTION 2 female red-necked wallabies (Macropus rufogriseus) were evaluated because of sudden-onset mandibular swelling, ptyalism, and hyporexia. CLINICAL FINDINGS Physical examination revealed a mandibular swelling with a fluctuant center in both wallabies. Hematologic analysis revealed leukocytosis with a mature neutrophilia and monocytosis in one wallaby (case 1) and a slight neutrophilia, hyperglobulinemia, and high serum alanine aminotransferase activity in the other (case 2). Cytologic examination of the swelling revealed a uniform population of gram-negative rods in case 1 and neutrophilic inflammation in case 2...
November 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29034527/age-of-onset-or-age-at-assessment-that-is-the-question-estimating-newly-incident-alcohol-drinking-and-rapid-transition-to-heavy-drinking-in-the-united-states-2002-2014
#4
Hui G Cheng, Catalina Lopez-Quintero, James C Anthony
Age-specific incidence estimates are important and useful facts in psychiatric epidemiology, but incidence estimation can be challenging. Methods artifacts are possible. In the United States, where the minimum legal drinking age is 21 years, recent cross-sectional field research on 12- to 25-year-olds applied conventional "age-at-assessment" approaches (AAA) for incidence estimation based on 12-month recall. Estimates disclosed unexpected nonlinear patterns in age-specific incidence estimates for both drinking onset and for transitioning from first drink to heavy drinking...
October 15, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29033673/automated-bone-scan-index-as-predictors-of-survival-in-prostate-cancer
#5
Joko Wiyanto, Rini Shintawati, Budi Darmawan, Basuki Hidayat, Achmad Hussein Sundawa Kartamihardja
Prostate cancer (PCa) is the second most diagnosed cancer in men. Early diagnosis and right management of PCa is critical to reducing deaths; the life expectancy is the main factors to be considered in the management of PCa. Among patients who die from PCa, the incidence of skeletal involvement appears to be >85%. Bone scan (BS) is the most common method for monitoring bone metastases in patients with PCa. The extent of bone metastasis was also associated with patient survival until now there is no clinically useful technique for measuring bone tumors and includes this information in the risk assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033146/the-prevalence-and-performance-of-resistance-exercise-training-activities-in-an-australian-population-in-relation-to-health-authority-guidelines
#6
Brendan Humphries, Rob Stanton, Aaron Scanlan, Mitch J Duncan
OBJECTIVES: Resistance training research highlights the importance of training intensity to resistance exercise training (RET) and the associated benefits to health and function for healthy and at-risk populations. The American College of Sports Medicine (ACSM) recommend specific intensities, frequencies, repetitions, and number of exercises of RET to be performed to maintain health. The primary aim of this study was to describe the prevalence of achieving recommended levels of RET in relation to ACSM guidelines for intensity, frequency, repetitions, and number of exercises in a regional Australian population...
September 29, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29031568/anxiety-disorders-in-old-age-psychiatric-comorbidities-quality-of-life-and-prevalence-according-to-age-gender-and-country
#7
Alessandra Canuto, Kerstin Weber, Marc Baertschi, Sylke Andreas, Jana Volkert, Maria Christina Dehoust, Susanne Sehner, Anna Suling, Karl Wegscheider, Berta Ausín, Mike J Crawford, Chiara Da Ronch, Luigi Grassi, Yael Hershkovitz, Manuel Muñoz, Alan Quirk, Ora Rotenstein, Ana Belén Santos-Olmo, Arieh Shalev, Jens Strehle, Hans-Ulrich Wittchen, Holger Schulz, Martin Härter
OBJECTIVES: Previous estimates of the prevalence of anxiety disorders in late life vary greatly due to the lack of reliable diagnostic tools. This MentDis_ICF65+ study assessed 12-month prevalence rates of anxiety disorders and age- and gender-related differences in comorbidities, as well as impact on quality of life. DESIGN: The study used a cross-sectional multicenter survey. PARTICIPANTS: The study sample comprised 3,142 men and women aged 65 to 84 years, living in five European countries and Israel...
September 5, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29031529/enhanced-surgical-outcomes-in-patients-with-skeletal-class-iii-facial-asymmetry-by-3-dimensional-surgical-simulation
#8
Ellen Wen-Ching Ko, Cheng-Hui Lin, Ying-An Chen, Yu-Ray Chen
PURPOSE: With the advance of image fusion techniques, the creation of 3-dimensional (3D) virtual head and 3D surgical simulations has provided previews of surgical procedures. The aim of this study was to investigate the surgical outcomes in patients receiving orthognathic surgery (OGS) with the guidance of 3D computer-assisted surgical simulation. PATIENTS AND METHODS: The study included 34 consecutive patients (15 men and 19 women; age, 18.1 to 33.0 yr) with skeletal Class III facial asymmetry who underwent bimaxillary OGS...
September 19, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29030276/dental-occlusal-surface-supported-titanium-guide-to-assist-cutting-and-drilling-in-mandibular-bilateral-sagittal-split-osteotomy
#9
Charles Savoldelli, Clair Vandersteen, Olivier Dassonville, Joseph Santini
INTRODUCTION: Cutting and drilling guides manufactured using computer-aided design/computer-aided manufacturing (CAD/CAM) technologies have attracted increasing interest in orthognathic surgery, particularly in complex cases. The development of these guides requires virtual surgery planning and three-dimensional modelling before they can be printed in titanium, polyamide, or resin. We report the use of a personalized titanium device to assist bilateral sagittal split osteotomy (BSSO) with or without genioplasty combined with individual implants for repositioning and fixation...
October 10, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29029874/sperm-subpopulations-in-ejaculated-sperm-and-spermatozoa-recovered-from-ovine-epididymides-up-to-48h-after-death
#10
Tácia Gomes Bergstein-Galan, Romildo Romualdo Weiss, Luiz Ernandes Kozicki, Sony Dimas Bicudo
The objectives of this study were threefold: to identify subpopulations of sperm based on the kinetics of frozen/thawed sheep epididymal spermatozoa or semen collected with an artificial vagina; to evaluate the effects on sperm subpopulations in the thawed samples of post mortem storage at room temperature and the addition of 20% of seminal plasma to the freezing extender and to correlate the percentage of subpopulations with gestation rate following artificial intrauterine insemination. The categorization of the subpopulations was based on sperm kinetic data from Computer Assisted Sperm Analysis (CASA)...
October 5, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29029728/software-dedicated-to-virus-sequence-analysis-bioinformatics-goes-viral
#11
Martin Hölzer, Manja Marz
Computer-assisted technologies of the genomic structure, biological function, and evolution of viruses remain a largely neglected area of research. The attention of bioinformaticians to this challenging field is currently unsatisfying in respect to its medical and biological importance. The power of new genome sequencing technologies, associated with new tools to handle "big data", provides unprecedented opportunities to address fundamental questions in virology. Here, we present an overview of the current technologies, challenges, and advantages of Next-Generation Sequencing (NGS) in relation to the field of virology...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/29029062/multicentric-evaluation-of-the-impact-of-central-tumour-location-when-comparing-rates-of-n1-upstaging-in-patients-undergoing-video-assisted-and-open-surgery-for-clinical-stage-i-non-small-cell-lung-cancer
#12
Herbert Decaluwé, René Horsleben Petersen, Alex Brunelli, Cecilia Pompili, Agathe Seguin-Givelet, Lucile Gust, Clemens Aigner, Pierre-Emmanuel Falcoz, Philippe Rinieri, Florian Augustin, Youri Sokolow, Ad Verhagen, Lieven Depypere, Kostas Papagiannopoulos, Dominique Gossot, Xavier Benoit D'Journo, Francesco Guerrera, Jean-Marc Baste, Thomas Schmid, Alessia Stanzi, Dirk Van Raemdonck, Jeremy Bardet, Pascal-Alexandre Thomas, Gilbert Massard, Steffen Fieuws, Johnny Moons, Christophe Dooms, Paul De Leyn, Henrik Jessen Hansen
OBJECTIVES: Large retrospective series have indicated lower rates of cN0 to pN1 nodal upstaging after video-assisted thoracic surgery (VATS) compared with open resections for Stage I non-small-cell lung cancer (NSCLC). The objective of our multicentre study was to investigate whether the presumed lower rate of N1 upstaging after VATS disappears after correction for central tumour location in a multivariable analysis. METHODS: Consecutive patients operated for PET-CT based clinical Stage I NSCLC were selected from prospectively managed surgical databases in 11 European centres...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29028921/smartpilot%C3%A2-view-guided-anaesthesia-improves-postoperative-outcomes-in-hip-fracture-surgery-a-randomized-blinded-controlled-study
#13
D Leblanc, M Conté, G Masson, F Richard, A Jeanneteau, G Bouhours, J M Chrétien, L Rony, E Rineau, S Lasocki
Background: Both under-dosage and over-dosage of general anaesthetics can harm frail patients. We hypothesised that computer-assisted anaesthesia using pharmacokinetic/pharmacodynamic models guided by SmartPilot® View (SPV) software could optimise depth of anaesthesia and improve outcomes in patients undergoing hip fracture surgery. Methods: This prospective, randomized, single-centre, blinded trial included patients undergoing hip fracture surgery under general anaesthesia...
September 27, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29028876/systematic-comparative-study-of-computational-methods-for-t-cell-receptor-sequencing-data-analysis
#14
Saira Afzal, Irene Gil-Farina, Richard Gabriel, Shahzad Ahmad, Christof von Kalle, Manfred Schmidt, Raffaele Fronza
High-throughput sequencing technologies have exposed the possibilities for the in-depth evaluation of T-cell receptor (TCR) repertoires. These studies are highly relevant to gain insights into human adaptive immunity and to decipher the composition and diversity of antigen receptors in physiological and disease conditions. The major objective of TCR sequencing data analysis is the identification of V, D and J gene segments, complementarity-determining region 3 (CDR3) sequence extraction and clonality analysis...
September 23, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29028216/clustering-of-morphological-features-for-identifying-femur-cavity-subtypes-with-difficulties-of-intramedullary-nail-implantation
#15
Fang Chen, Zhe Zhao, Jia Liu, Cong Gao, Xiuyun Su, Jingxin Zhao, Peifu Tang, Hongen Liao
Intramedullary (IM) nail implantation is currently the standard treatment for femoral intertrochanteric fractures. However, individual differences in femur cavity bring a challenge in designing well-matched IM nails and cause difficulties in IM nail implantation. Therefore, there is an intense need to analyze femur cavities to predict difficulties in IM nail implantation to assist the design of IM nails. This study proposed a method to automatically identify subtypes of femur cavities that exhibit differences in potential difficulties in nail implantation by clustering the morphological features of femur models...
October 11, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/29026518/castleman-s-disease-a-rare-presentation-in-a-retroperitoneal-accessory-spleen-treated-with-a-minimally-invasive-robotic-approach
#16
Fabio Sbrana, Dimin Zhou, Ina Zamfirova, Nathaniel Leonardi
Unicentric Castleman's disease (UCD) is a rare disorder of unknown etiology characterized by localized lymphoid tissue proliferation and interfollicular hypervascularity. A 33-year-old Caucasian female presented with vague abdominal discomfort and pain with pressure. Ultrasound and computed tomography detected a large peripancreatic mass. Robotic-assisted resection of the mass along with en bloc dissection of the encased left adrenal gland was done. Frozen section examination confirmed UCD hyaline vascular variant in a retroperitoneal accessory spleen...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29026441/modeling-the-architecture-of-the-regulatory-system-controlling-methylenomycin-production-in-streptomyces-coelicolor
#17
Jack E Bowyer, Emmanuel Lc de Los Santos, Kathryn M Styles, Alex Fullwood, Christophe Corre, Declan G Bates
BACKGROUND: The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the associated biosynthetic, regulatory and resistance genes are located on a single cluster on the SCP1 plasmid, making the entire module easily transferable between different bacterial strains. Understanding further the regulation and biosynthesis of the methylenomycin producing gene cluster could assist in the identification of motifs that can be exploited in synthetic regulatory systems for the rational engineering of novel natural products and antibiotics...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/29026438/mental-health-assessments-in-refugees-and-asylum-seekers-evaluation-of-a-tablet-assisted-screening-software
#18
Naser Morina, Simon M Ewers, Sandra Passardi, Ulrich Schnyder, Christine Knaevelsrud, Julia Müller, Richard A Bryant, Angela Nickerson, Matthis Schick
BACKGROUND: Mental health problems resulting from persecution and forced migration are very common among refugees and asylum seekers and evolve into a major public health challenge in hosting societies. Language barriers often prevent timely access to appropriate health care, leading to chronic trajectories and abortive social integration. Tools for multilingual screening and assessment could be of great benefit for this particularly vulnerable population as well as for policy makers...
2017: Conflict and Health
https://www.readbyqxmd.com/read/29026365/incidental-finding-of-bronchopulmonary-sequestration-in-a-64-year-old-female
#19
Pichapong Tunsupon, Ayesha Arshad, Sumit Patel, M Jeffery Mador
BACKGROUND: Bronchopulmonary sequestration is a congenital abnormality of the primitive foregut. In adults, the typical age at presentation is 20-25 years. CASE REPORT: A 64-year-old female was referred for evaluation of an 8 × 6-cm right lower lobe cystic lesion. Her medical history was significant for recurrent right lower lobe pneumonia requiring multiple hospitalizations. Her physical examination was significant for crackles at the right lung base. Computed tomography (CT) of the chest with contrast showed cystic changes with thickened septation of the medial segment of the right lower lobe lacking distinct visceral pleura and with arterial supply from the anomalous branch of the thoracic aorta arising near the celiac trunk...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29025693/characterizing-active-ingredients-of-ehealth-interventions-targeting-persons-with-poorly-controlled-type-2-diabetes-mellitus-using-the-behavior-change-techniques-taxonomy-scoping-review
#20
Mihiretu M Kebede, Tatjana P Liedtke, Tobias Möllers, Claudia R Pischke
BACKGROUND: The behavior change technique taxonomy v1 (BCTTv1; Michie and colleagues, 2013) is a comprehensive tool to characterize active ingredients of interventions and includes 93 labels that are hierarchically clustered into 16 hierarchical clusters. OBJECTIVE: The aim of this study was to identify the active ingredients in electronic health (eHealth) interventions targeting patients with poorly controlled type 2 diabetes mellitus (T2DM) and relevant outcomes...
October 12, 2017: Journal of Medical Internet Research
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