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https://www.readbyqxmd.com/read/28531820/adverse-effects-and-treatment-satisfaction-among-online-users-of-four-antidepressants
#1
Shannon Hughes, Jeffrey Lacasse, Reid Rogers Fuller, Jennifer Spaulding-Givens
Adverse effects (AEs) are an important factor in antidepressant treatment decision-making, though common AE profiles from clinical trial research highlight physical AEs to the neglect of emotional and behavioral AEs. First-hand accounts of antidepressant users on the Internet can supplement AE profiles with information gained from real-world treatment experiences. We examined online user reviews of two older (escitalopram; duloxetine) and two newer (vilazodone; vortioxetine) antidepressants for differences in their AE profiles and determined which categories of AEs were associated with users' satisfaction...
May 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28531576/associations-between-anthropometric-indices-and-the-severity-of-obstructive-sleep-apnea
#2
Ioanna Kechribari, Michael Georgoulis, Meropi D Kontogianni, Emmanuel Vagiakis, Nikos Yiannakouris
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531336/loop-gain-predicts-the-response-to-upper-airway-surgery-in-patients-with-obstructive-sleep-apnoea-ventilatory-control-abnormalities-predict-surgical-responsiveness
#3
Simon A Joosten, Paul Leong, Shane A Landry, Scott A Sands, Philip I Terrill, Dwayne Mann, Anthony Turton, Jhanavi Rangaswamy, Christopher Andara, Glen Burgess, Darren Mansfield, Garun S Hamilton, Bradley A Edwards
Study Objectives: Upper airway surgery is often recommended to treat OSA patients who cannot tolerate continuous positive airways pressure (CPAP). However, the response to surgery is variable, potentially because it does not improve the non-anatomical factors (i.e. loop gain and arousal threshold) causing OSA. Measuring these traits clinically might predict responses to surgery. Our primary objective was to test the value of loop gain and arousal threshold to predict surgical success defined as 50% reduction in apnea-hypopnea index (AHI) and AHI <10 events/hr post-surgery...
May 22, 2017: Sleep
https://www.readbyqxmd.com/read/28531332/are-sleep-problems-a-risk-factor-for-the-onset-of-musculoskeletal-pain-in-children-and-adolescents-a-systematic-review
#4
Alessandro Andreucci, Paul Campbell, Kate M Dunn
Study objectives: Musculoskeletal pain is a major burden on society. Adults with sleep problems are at higher risk for musculoskeletal pain onset, but there is no evidence for this relationship in children and adolescents. This study aimed to systematically review prospective studies on the risk for musculoskeletal pain onset in children and adolescents with sleep problems. Methods: Five databases (MEDLINE, PsycINFO, AMED, EMBASE, HMIC) were systematically searched to identify prospective studies that investigated if children and adolescents (aged 6-19 years) with sleep problems are at higher risk for musculoskeletal pain onset...
May 20, 2017: Sleep
https://www.readbyqxmd.com/read/28531258/the-reproducibility-of-racial-differences-in-ambulatory-blood-pressure-phenotypes-and-measurements
#5
Aamir Husain, Feng-Chang Lin, Laura A Tuttle, Emily Olsson, Anthony J Viera
BACKGROUND: We examined the reproducibility of differences in ambulatory blood pressure (BP) monitoring (ABPM) phenotypes and other parameters (sustained hypertension, masked hypertension, nocturnal hypertension, and nondipping) between African Americans and Whites. METHODS: A total of 420 participants untreated for hypertension attended 2 research visits 1 week apart during which traditional office BP averages and ABPM session averages were determined. We computed percent agreement in ABPM phenotypes across the 2 visits stratified by race and associated kappa statistics with 95% confidence intervals...
May 22, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28531237/burden-of-neurological-diseases-in-the-us-revealed-by-web-searches
#6
Ricardo Baeza-Yates, Puneet Mohan Sangal, Pablo Villoslada
BACKGROUND: Analyzing the disease-related web searches of Internet users provides insight into the interests of the general population as well as the healthcare industry, which can be used to shape health care policies. METHODS: We analyzed the searches related to neurological diseases and drugs used in neurology using the most popular search engines in the US, Google and Bing/Yahoo. RESULTS: We found that the most frequently searched diseases were common diseases such as dementia or Attention Deficit/Hyperactivity Disorder (ADHD), as well as medium frequency diseases with high social impact such as Parkinson's disease, MS and ALS...
2017: PloS One
https://www.readbyqxmd.com/read/28531148/early-childhood-dental-caries-mouth-pain-and-malnutrition-in-the-ecuadorian-amazon-region
#7
Marvin So, Yianni A Ellenikiotis, Hannah M Husby, Cecilia Leonor Paz, Brittany Seymour, Karen Sokal-Gutierrez
Malnutrition and dental caries in early childhood remain persistent and intertwined global health challenges, particularly for indigenous and geographically-remote populations. To examine the prevalence and associations between early childhood dental caries, parent-reported mouth pain and malnutrition in the Amazonian region of Ecuador, we conducted a cross-sectional study of the oral health and nutrition status of 1407 children from birth through age 6 in the "Alli Kiru" program (2011-2013). We used multivariate regression analysis to examine relationships between severe caries, parent-reported mouth pain measures, and nutritional status...
May 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28530876/research-continuous-surveillance-of-sleep-apnea-patients-in-a-medical-surgical-unit
#8
Dana Supe, Leah Baron, Tom Decker, Kyle Parker, Jeanne Venella, Sarah Williams, Kari Beaton, John Zaleski
This report consists of two separate studies on the use of continuous capnography monitoring conducted in an effort to improve patient safety at Virtua Health System. The desire for improved patient safety is motivating continuous monitoring and improved surveillance in clinical areas not traditionally equipped for such monitoring. We explored the use of remote monitoring of capnography, using enterprise middleware, in patients recovering from surgery in a medical-surgical unit. Continuous monitoring traditionally has been used in higher-acuity settings, such as intensive care units...
May 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28530487/effects-of-pre-season-training-on-the-sleep-characteristics-of-professional-rugby-league-players
#9
Heidi R Thornton, Jace A Delaney, Grant M Duthie, Ben J Dascombe
PURPOSE: To investigate the influence of daily and exponentially-weighted moving training loads on subsequent night-time sleep. METHODS: Sleep of fourteen professional rugby league athletes competing in the National Rugby League competition was recorded using wristwatch actigraphy. Physical demands were quantified using GPS technology, including total distance (TD), high-speed distance (HSD), acceleration/deceleration load (SumAccDec; AU), and sRPE (AU). Linear mixed models determined effects of acute (daily) and sub-acute (three- and seven-day) exponentially-weighted moving averages (EWMA) on sleep...
May 22, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28530462/using-yoga-nidra-to-improve-stress-in-psychiatric-nurses-in-a-pilot-study
#10
Roberta Anderson, Kristine Mammen, Padmini Paul, Allisyn Pletch, Kathleen Pulia
Given today's hurried and stressful heathcare system, nurses need mechanisms to take care of themselves, promote their own wellness, and build resilience in managing sick patients. Yoga is one such mechanism; it can decrease anxiety and improve sleep and quality of life. In this pilot study, nine nurses participated in 6 weekly sessions of yoga nidra. Measures of sleep, stress, and muscle fatigue were obtained to determine whether yoga had a positive impact upon quality of life and stress. Although based on a small sample of nurses, results indicated positive findings for both perceived stress level and muscle fatigue...
May 22, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28530456/-the-probability-of-obstructive-sleep-apnea-disorders-emergence-by-odds-ratio-of-main-risk-factors
#11
Krisztina Szabó, Ferenc Ihász
INTRODUCTION: The quality of sleep plays a serious role in the individual's daytime performace and state of health, there by it has a strong influence on the society. AIM: The present study measures the probability developing and severity of obstructive sleep apnea syndrome, - which belongs to group of disorders of the respiratory - through odds ratio of leading risk factors. METHOD: 127 persons were examined in the test. The sleep structure test data were processed by polysomnographic screening device...
May 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28530341/-measuring-the-effect-of-multi-sensory-stimulation-in-the-snoezelen-room-on-sleep-quality-of-alzheimer-patients-using-actigraph
#12
Doron Todder, Meital Levartovsky, Tzvi Dwolatzky
BACKGROUND: The most common cause of dementia is Alzheimer's disease. The major manifestation of the disease is the cognitive impairment which appears at the onset of the disease. In addition to the cognitive impairment there are behavioral dysfunctions such as apathy, anxiety, depression and sleep disturbances. The treatment for the manifestations of Alzheimer is currently pharmacological and behavioral. One of the newest behavioral treatments for Alzheimer is the multi-sensory treatment using the Snoezelen room...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28530334/-from-theory-to-practice-implementing-the-bio-psycho-social-model-in-clinical-and-research-activities-in-the-beer-sheva-mental-health-center
#13
Hagit Cohen, Doron Todder
The Beer Sheva Mental Health Center is the second largest mental health hospital in Israel and provides acute and chronic in-patient services for the entire population of the Southern District of Israel, from Ashdod to Eilat (about 1.2 million people) from adolescence to the elderly. The outpatient services include a variety of regional specialty services such as bipolar, eating disorders, anxiety, neuromodulation, gender-oriented, attention deficit hyperactivity disorder, sleep, dual diagnosis, geronto-psychiatry and post-traumatic stress disorder clinics and various rehabilitation day-care services...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28530315/-syndrome-of-obstructive-sleep-apnea-in-the-elderly-population-prevalence-clinical-characteristics-and-treatment-strategy
#14
REVIEW
Boris Punchik, Yan Press, Aviv Goldbart
Obstructive sleep apnea syndrome - a common problem among old people, reduces the quality of life and is accompanied by increased morbidity and mortality. There are tests that enable early detection and diagnosis of this condition and there are effective treatments. This review will focus on the following topics: • The importance of the problem • Review of diagnostic tools • Treatment guidelines • How to improve adherence of patients to treatment.
January 2017: Harefuah
https://www.readbyqxmd.com/read/28530254/palatal-surgery-in-a-transoral-robotic-setting-tors-preliminary-results-of-a-retrospective-comparison-between-uvulopalatopharyngoplasty-uppp-expansion-sphincter-pharyngoplasty-esp-and-barbed-repositioning-pharyngoplasty-brp
#15
G Cammaroto, F Montevecchi, G D'Agostino, E Zeccardo, C Bellini, G Meccariello, C Vicini
It has become increasingly clear in the past decade that surgical management of obstructive sleep apnoea hypopnoea syndrome (OSAHS) is most successfully managed with multilevel surgery. We evaluated the outcomes of multilevel interventions comparing three different palatal techniques added to TORS: uvulopalatopharyngoplasty (UPPP), a modified expansion sphincter pharyngoplasty (ESP), inspired by the Pang expansion sphincter pharyngoplasty technique and the latest barbed repositioning pharyngoplasty (BRP). Thirty patients were retrospectively evaluated...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28530229/deep-sleep-maintains-learning-efficiency-of-the-human-brain
#16
Sara Fattinger, Toon T de Beukelaar, Kathy L Ruddy, Carina Volk, Natalie C Heyse, Joshua A Herbst, Richard H R Hahnloser, Nicole Wenderoth, Reto Huber
It is hypothesized that deep sleep is essential for restoring the brain's capacity to learn efficiently, especially in regions heavily activated during the day. However, causal evidence in humans has been lacking due to the inability to sleep deprive one target area while keeping the natural sleep pattern intact. Here we introduce a novel approach to focally perturb deep sleep in motor cortex, and investigate the consequences on behavioural and neurophysiological markers of neuroplasticity arising from dedicated motor practice...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28530204/in-bed-vital-signs-monitoring-system-based-on-unobtrusive-magnetic-induction-method-with-a-concentric-planar-gradiometer
#17
Hadiseh Mahdavi, Javier Rosell-Ferrer
SIGNIFICANCE: Unobtrusive vital signs monitoring is of major importance for various medical areas such as detection and treatment of sleep disorders, monitoring neonates and burned victims, home health care and smart home applications and wearables among others. Such applications call for monitoring methods in which the patient's natural state is less interfered with. An ideal device would be non-invasive, minimally restrictive, robust enough to compensate movements of the patients, and would operate without relying on the patient's full cooperation...
June 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28530153/baseline-sleep-efficiency-and-arousal-index-do-not-predict-who-will-benefit-from-sedatives-in-improving-positive-airway-pressure-adherence-in-sleep-apnea-to-90
#18
R Bart Sangal
Positive airway pressure (PAP) is the preferred treatment for obstructive sleep apnea (OSA), but adherence is low. Educational or ongoing supportive intervention improves the number of PAP adherent patients from the 50% to the 70% range. A common side effect of PAP is increased awakenings. This prospective trial examined baseline polysomnographically derived sleep efficiency and arousal index in PAP adherent and nonadherent patients, and in patients needing sedating medicines to attain PAP adherence versus those who did not need such medicines...
May 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28530143/intranasal-melatonin-nanoniosomes-pharmacokinetic-pharmacodynamics-and-toxicity-studies
#19
Aroonsri Priprem, Jeffrey R Johns, Sucharat Limsitthichaikoon, Wanwisa Limphirat, Pramote Mahakunakorn, Nutjaree Prateepawanit Johns
AIM: Intranasal melatonin encapsulated in nanosized niosomes was preclinically evaluated. METHODOLOGY: A formula of melatonin niosomes (MN) was selected through physicochemical and cytotoxic data for pharmacokinetic, pharmacodynamics and toxicity studies in male Wistar rats. RESULTS: Intranasal MN was bioequivalent to intravenous injection of melatonin, providing therapeutic level doses. Acute and subchronic toxicity screening showed no abnormal signs, symptoms or hematological effects in any animals...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530135/prolonged-expression-of-secreted-enzymes-in-dogs-after-liver-directed-delivery-of-i-sleeping-beauty-i-transposons-implications-for-non-viral-gene-therapy-of-systemic-disease
#20
Elena L Aronovich, Kendra Anne Hyland, Bryan C Hall, Jason B Bell, Erik R Olson, Myra Urness Rusten, David W Hunter, N Matthew Ellinwood, R Scott McIvor, Perry B Hackett
The non-viral, integrating Sleeping Beauty (SB) transposon system is efficient in treating systemic monogenic disease in mice including hemophilias A and B caused by deficiency of blood clotting factors and mucopolysaccharidosis (MPS) types I and VII caused by α-L-iduronidase (IDUA) and β-glucuronidase (GUSB) deficiency, respectively. We recently reported modified approaches of the hydrodynamics-based procedure to deliver transposons to the liver in dogs. Using the transgenic canine reporter secreted alkaline phosphatase (cSEAP), we demonstrated transgenic protein in the plasma for up to six weeks post-infusion...
May 20, 2017: Human Gene Therapy
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