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https://www.readbyqxmd.com/read/29778079/advances-in-understanding-the-response-of-fish-to-linear-alcohols-in-the-environment
#1
Scott E Belanger, Jane M Rawlings, Ricky Stackhouse
Short to long chain alcohols have a range of ecotoxicity to aquatic life driven by hydrophobic interactions with biological membranes. Carbon chain length and octanol:water partitioning coefficients are surrogates for hydrophobicity and strongly relate to aquatic toxicity. In these investigations, the toxicity of ethanol to 1-n-dodecanol to juvenile fish in standard acute toxicity tests is reviewed. Toxicity tests employing fish embryos (zebrafish Danio rerio and fathead minnow Pimephales promelas) in the Fish Embryo Test (OECD 236) format were conducted from C2 to C10 to compare against standard juvenile fish toxicity...
April 25, 2018: Chemosphere
https://www.readbyqxmd.com/read/29773699/comparison-of-the-effect-of-immediate-versus-delayed-transfer-following-a-stimulated-ivf-cycle-on-the-ongoing-pregnancy-rate-of-frozen-thawed-embryo-transfer-cycles-a-study-protocol-for-a-randomised-controlled-trial
#2
He Li, Lu Li, Xiang Lu, Xiaoxi Sun, Ernest Hung Yu Ng
INTRODUCTION: Frozen-thawed embryo transfer (FET) has become an increasingly important part of in-vitro fertilisation (IVF) treatment. Currently, there is still no good scientific evidence to support when to perform FET following a stimulated IVF cycle. Since all published studies are retrospective and the findings are contradictory, a randomised controlled study is needed to provide Level 1 evidence to guide the clinical practice. METHODS/ANALYSIS: This is a randomised controlled trial...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29771491/modification-of-side-chains-of-conjugated-molecules-and-polymers-for-charge-mobility-enhancement-and-sensing-functionality
#3
Zitong Liu, Guanxin Zhang, Deqing Zhang
Organic semiconductors have received increasing attentions in recent years because of their promising applications in various optoelectronic devices. The key performance metric for organic semiconductors is charge carrier mobility, which is governed by the electronic structures of conjugated backbones and intermolecular/interchain π-π interactions and packing in both microscopic and macroscopic levels. For this reason, more efforts have been paid to the design and synthesis of conjugated frameworks for organic semiconductors with high charge mobilities...
May 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29771117/correlating-charge-transport-to-structure-in-deconstructed-diketopyrrolopyrrole-oligomers-a-case-study-of-a-monomer-in-field-effect-transistors
#4
Alec Pickett, Mika Torkkeli, Tushita Mukhopadhyay, Boregowda Puttaraju, Amrit Laudari, Andreas Lauritzen, Oier Bikondoa, Jakob Kjelstrup-Hansen, Matti Knaapila, Satish Patil, Suchismita Guha
Copolymers based on diketopyrrolopyrrole (DPP) cores have attracted a lot of attention due to their high p-type as well as n-type carrier mobilities in organic field-effect transistors (FETs) and high power conversion efficiencies in solar cell structures. We report the structural and charge transport properties of n-dialkyl side-chain substituted thiophene DPP end-capped with a phenyl group (Ph-TDPP-Ph) in FETs which were fabricated by vacuum deposition and solvent coating. Grazing incidence X-ray diffraction (GIXRD) from bottom-gate, bottom-contact FET architectures were measured with and without biasing...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29771108/realizing-long-term-stability-and-thickness-control-of-black-phosphorus-by-ambient-thermal-treatment
#5
Min-Hye Jeong, Dohyun Kwak, Hyun-Soo Ra, A-Young Lee, Jong-Soo Lee
Few-layer black phosphorus has shown great potential for next-generation electronics with tunable band gap and high carrier mobility. For the electronic applications, the thickness modulation of a BP flake is an essential due to its thickness-dependent electronic properties. However, controlling the precise thickness of few-layer BP is a challenge for the high-performance device applications. In this study, we demonstrate that thermal treatment under ambient condition precisely controls the thickness of BP flake...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29770576/the-extracellular-zn-2-concentration-surrounding-excited-neurons-is-high-enough-to-bind-amyloid-%C3%AE-revealed-by-a-nanowire-transistor
#6
Ankur Anand, Chih-Hung Chi, Subhasree Banerjee, Ming-Yi Chou, Fan-Gang Tseng, Chien-Yuan Pan, Yit-Tsong Chen
The Zn2+ stored in the secretory vesicles of glutamatergic neurons is coreleased with glutamate upon stimulation, resulting in the elevation of extracellular Zn2+ concentration (CZn2+ex). This elevation of CZn2+ex regulates the neurotransmission and facilitates the fibrilization of amyloid-β (Aβ). However, the exact CZn2+ex surrounding neurons under (patho)physiological conditions is not clear and the connection between CZn2+ex and the Aβ fibrilization remains obscure. Here, a silicon nanowire field-effect transistor (SiNW-FET) with the Zn2+ -sensitive fluorophore, FluoZin-3 (FZ-3), to quantify the CZn2+ex in real time is modified...
May 16, 2018: Small
https://www.readbyqxmd.com/read/29767500/enhanced-performance-of-field-effect-transistors-based-on-black-phosphorus-channels-reduced-by-galvanic-corrosion-of-al-over-layers
#7
Sangik Lee, Chansoo Yoon, Ji Hye Lee, Yeon Soo Kim, Mi Jung Lee, Wondong Kim, Jaeyoon Baik, Quanxi Jia, Bae Ho Park
Two-dimensional (2D) layered semiconducting materials with considerable bandgaps are emerging as a new class of materials applicable to next-generation devices. Particularly, black phosphorus (BP) is considered to be very promising for next-generation 2D electrical and optical devices due to its high carrier mobility of 200-1000 cm2 V-1 s-1 and large on/off ratio of 104 -105 in field effect transistors. However, its environmental instability in air requires fabrication processes in a glove box filled with nitrogen or argon gas followed by encapsulation, passivation, and chemical functionalization of BP...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29767497/highly-sensitive-and-reusable-membraneless-field-effect-transistor-fet-type-tungsten-diselenide-wse-2-biosensors
#8
Hae Won Lee, Dong-Ho Kang, Jeong Ho Cho, Sungjoo Lee, Dong-Hwan Jun, Jin-Hong Park
In recent years when the demand for high-performance biosensors has been aroused, a field-effect transistor (FET)-type biosensor (BioFET) has attracted great interest because of its high sensitivity, label-free detection, fast detection speed, and miniaturization. However, the insulating membrane in the conventional BioFET, which is essential in preventing the surface dangling bonds of typical semiconductors from nonspecific bindings, has limited the sensitivity of biosensors. Here, we present a highly sensitive and reusable membraneless BioFET based on a defect-free van der Waals material, tungsten diselenide (WSe2 )...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29764212/the-clinical-application-of-single-sperm-based-snp-haplotyping-for-pgd-of-osteogenesis-imperfecta
#9
Linjun Chen, Zhenyu Diao, Zhipeng Xu, Jianjun Zhou, Guijun Yan, Haixiang Sun
Osteogenesis imperfecta (OI) is a genetically heterogeneous disorder, presenting either autosomal dominant, autosomal recessive or X-linked inheritance patterns. The majority of OI cases are autosomal dominant and are caused by heterozygous mutations in either the COL1A1 or COL1A2 gene. In these dominant disorders, allele dropout (ADO) can lead to misdiagnosis in preimplantation genetic diagnosis (PGD). Polymorphic markers linked to the mutated genes have been used to establish haplotypes for identifying ADO and ensuring the accuracy of PGD...
May 15, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29761971/-the-application-of-silicon-nanowires-field-effect-transistor-biosensor-in-medicine
#10
REVIEW
Zengtao Bao, Tong Wang
Ultra-sensitive and quantitative analysis of proteins, nucleic acid, virus and other biochemical species are critical technologies for effective dianosis of disease, as well as medical studies. Silicon nanowires field-effect transistor (SiNWs-FET) biosensor is one of the most promising powerful platforms for label-free, real-time, ultra-sensitive detection of analyte. Here, the working principle of SiNWs-FET biosensor and the applications of SiNWs-FET biosensors in medicine were introduced. Moreover, the methods for enhancing the sensitivity of SiNWs-FET biosensor were discussed...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29754968/recurrent-pseudoprogression-in-isocitrate-dehydrogenase-1-mutant-glioblastoma
#11
Sied Kebir, Laurèl Rauschenbach, Gerrit H Gielen, Niklas Schäfer, Theophilos Tzaridis, Björn Scheffler, Frank A Giordano, Lazaros Lazaridis, Ulrich Herrlinger, Martin Glas
In a subset of glioblastoma (GBM) patients, the differentiation between tumor progression and tumor pseudoprogression (PsP) is challenging. This case describes a male patient suffering from isocitrate dehydrogenase 1 (IDH1) mutant GBM who demonstrated an increasing contrast-enhancing (CE) lesion on a cranial magnetic resonance imaging (cMRI) scan 8 months after radiochemotherapy. In accordance with the response assessment in neuro-oncology (RANO) criteria, the cMRI lesion was classified as recurrent tumor, although 18 F-fluoroethyl-L-tyrosine positron emission tomography (18 F-FET-PET) did not indicate vital tumor tissue...
May 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29752687/a-phase-ii-study-evaluating-the-efficacy-of-zoledronic-acid-in-prevention-of-aromatase-inhibitor-associated-musculoskeletal-symptoms-the-zap-trial
#12
Cesar A Santa-Maria, Aditya Bardia, Amanda L Blackford, Claire Snyder, Roisin M Connolly, John H Fetting, Daniel F Hayes, Stacie C Jeter, Robert S Miller, Anne Nguyen, Katie Quinlan, Gary L Rosner, Shannon Slater, Anna Maria Storniolo, Antonio C Wolff, Jane Zorzi, Nora Lynn Henry, Vered Stearns
PURPOSE: Aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) are common adverse events of AIs often leading to drug discontinuation. We initiated a prospective clinical trial to evaluate whether bisphosphonates are associated with reduced incidence of AIMSS. METHODS: In the single-arm trial, the Zoledronic Acid Prophylaxis (ZAP) trial, we compared the incidence of AIMSS against historical controls from the Exemestane and Letrozole Pharmacogenomics (ELPh) trial...
May 11, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29751688/cmos-compatible-silicon-nanowire-field-effect-transistor-biosensor-technology-development-toward-commercialization
#13
REVIEW
Duy Phu Tran, Thuy Thi Thanh Pham, Bernhard Wolfrum, Andreas Offenhäusser, Benjamin Thierry
Owing to their two-dimensional confinements, silicon nanowires display remarkable optical, magnetic, and electronic properties. Of special interest has been the development of advanced biosensing approaches based on the field effect associated with silicon nanowires (SiNWs). Recent advancements in top-down fabrication technologies have paved the way to large scale production of high density and quality arrays of SiNW field effect transistor (FETs), a critical step towards their integration in real-life biosensing applications...
May 11, 2018: Materials
https://www.readbyqxmd.com/read/29751397/microplastic-accumulation-patterns-and-transfer-of-benzo-a-pyrene-to-adult-zebrafish-danio-rerio-gills-and-zebrafish-embryos
#14
Annika Batel, Flora Borchert, Hannes Reinwald, Lothar Erdinger, Thomas Braunbeck
Since only a few studies have investigated effects of microplastics (MPs) by routes other than ingestion, this study was designed to analyze the accumulation patterns and transfer of toxic substances associated with microplastic exposure by simple attachment to (1) adult zebrafish (Danio rerio) gills and (2) zebrafish embryos. Two sizes of fluorescently labelled polymers (1-5 and 10-20 μm) loaded with the model polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BaP) were used to analyze fate, accumulation and transfer of microplastic-associated persistent organic pollutants (POPs) on gills and embryos...
April 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29750927/frozen-elephant-trunk-for-acute-type-b-dissection-involving-the-distal-arch-in-the-hybrid-repair-era
#15
Rui-Dong Qi, Jun-Ming Zhu, Yong-Min Liu, Lei Chen, Cheng-Nan Li, Xiao-Yan Xing, Nan Zhang, Li-Zhong Sun
BACKGROUND: Hybrid repair of complicated acute type B aortic dissection(ATBAD) with aortic arch involvement is associated with a high rate of endoleak, stroke, and retrograde aortic dissection. Optimal management of this lesion remains uncertain. In this hybrid repair era, surgical results of ATBAD with distal aortic arch involvement using a frozen elephant trunk(FET) procedure with left subclavian artery(LSCA)-left common carotid artery(LCCA) transposition is reported. METHODS: From April 2011 to April 2016, 53 patients with complicated ATBAD with distal aortic arch involvement underwent a FET procedure with LSCA-LCCA transposition...
May 8, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29740927/are-singleton-pregnancies-after-assisted-reproduction-technology-art-associated-with-a-higher-risk-of-placental-anomalies-compared-with-non-art-singleton-pregnancies-a-systematic-review-and-meta-analysis
#16
REVIEW
B G Vermey, A Buchanan, G M Chambers, E M Kolibianakis, J Bosdou, M G Chapman, C A Venetis
BACKGROUND: Placental anomalies (placenta praevia, placental abruption, morbidly adherent placenta and cord insertion anomalies) are associated with maternal and fetal morbidity and mortality. It has been suggested these might be more prevalent in pregnancies after assisted reproduction technology (ART). OBJECTIVES: To determine whether ART singleton pregnancies are associated with an increased risk of placental anomalies compared with non-ART singleton pregnancies...
May 8, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29740097/impact-of-18-f-fet-pet-on-target-volume-definition-and-tumor-progression-of-recurrent-high-grade-glioma-treated-with-carbon-ion-radiotherapy
#17
Charlotte Debus, Maria Waltenberger, Ralf Floca, Ali Afshar-Oromieh, Nina Bougatf, Sebastian Adeberg, Sabine Heiland, Martin Bendszus, Wolfgang Wick, Stefan Rieken, Uwe Haberkorn, Jürgen Debus, Maximilian Knoll, Amir Abdollahi
High-precision radiotherapy (HPR) of recurrent high grade glioma (HGG) requires accurate spatial allocation of these infiltrative tumors. We investigated the impact of 18 F-FET PET on tumor delineation and progression of recurrent HGG after HPR with carbon ions. T1 contrast enhanced MRI and 18 F-FET-PET scans of 26 HGG patients were fused with radiotherapy planning volumes. PET-positive (PET+) tumor volumes using different isocontours (I%) were systematically investigated and compared with MRI-derived gross tumor volumes (GTV)...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739361/two-successful-pregnancies-following-fertility-preservation-in-a-patient-with-anaplastic-astrocytoma-a-case-report
#18
Alexandra Peyser, Sara L Bristow, Avner Hershlag
BACKGROUND: Astrocytomas are the most common malignant glial tumors. With improved prognosis, it is possible for patients to pursue pregnancy post-treatment. However, with potential gonadotoxicity of oncology treatments, fertility preservation prior to chemotherapy and/or radiation therapy should be considered. This requires close collaboration between the oncologist and reproductive endocrinologist. To our knowledge this is the first report of successful pregnancies following fertility preservation for AA...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29737471/does-the-endometrial-receptivity-array-really-provide-personalized-embryo-transfer
#19
Rawad Bassil, Robert Casper, Nivin Samara, Tzu-Bou Hsieh, Eran Barzilay, Raoul Orvieto, Jigal Haas
PURPOSE: The aim of the present study was to determine the percentage of infertility patients who are diagnosed with a non-receptive endometrium according to the endometrial receptivity array (ERA) test and to examine whether adjusting the embryo transfer day according to the proposed shift in the window of implantation improves the pregnancy rate compared to non-ERA-tested patients. METHODS: A single-center retrospective cohort study, including 53 consecutive good prognosis patients (0-2 previous frozen embryo transfers) admitted to our IVF unit for a mock cycle prior to their frozen day-5 embryo (blastocyst) transfer cycle...
May 8, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29734407/effect-of-developmental-stage-of-embryos-at-freezing-on-live-birth-outcomes-after-frozen-embryo-transfer
#20
X J Zhang, Q Lv, L H Min, X H Cao, X J Li
  Purpose Our objective was to evaluate the birth outcomes of FET from different developmental stage of embryo at freezing (Day 3, Day 5 and Day 6). Methods All vitrified-warmed day 3 (D3) and day 5/6 (D5, D6) embryo transfers during the time period from January 2013 until December 2015 were included in the study. The Birthweight, Low birthweight (LBW), sexual distinction, gestation and for singleton births and twins conceived by FET were compared retrospectively between three cryopreservation strategies utilizing either D3, D5 or D6 embryo freezing...
September 2017: Cryo Letters
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