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https://www.readbyqxmd.com/read/28095720/baseline-chromogranin-a-and-its-dynamics-are-prognostic-markers-in-gastroenteropancreatic-neuroendocrine-tumors
#1
Wojciech Rogowski, Ewa Wachuła, Anna Lewczuk, Agnieszka Kolesińska-Ćwikła, Ewa Iżycka-Świeszewska, Violetta Sulżyc-Bielicka, Jarosław B Ćwikła
AIM: This study assessed whether absolute chromogranin A (CgA) values at various stages of treatment have prognostic value in patients with pancreatic and midgut neuroendocrine tumors, subjected to peptide receptor radionuclide therapy with (90)Y-[DOTA(0), D-Phe(1), Tyr(3)]-octreotate. PATIENTS & METHODS: CgA was determined before peptide receptor radionuclide therapy, 6 weeks, 6, 12, 18 and 24 months after the last dose of (90)Y-[DOTA(0), D-Phe(1), Tyr(3)]-octreotate...
January 18, 2017: Future Oncology
https://www.readbyqxmd.com/read/28088700/chlorogenic-acid-ameliorated-concanavalin-a-induced-hepatitis-by-suppression-of-toll-like-receptor-4-signaling-in-mice
#2
Yinglin Yuan, Xia Gong, Li Zhang, Rong Jiang, Junxia Yang, Bin Wang, Jingyuan Wan
Chlorogenic acid (CGA), one of the most abundant dietary polyphenolic compounds, has been reported to exhibit anti-inflammatory ability. However, the hepatoprotective effects and molecular mechanisms of CGA on concanavalin A (Con A)-induced hepatitis have not been explored. In the present study, we found that pretreatment with CGA dose-dependently inhibited the elevation of plasma aminotransferases and alleviated hepatic pathological damage as well as hepatocyte apoptosis in Con A-exposed mice. Additionally, CGA markedly suppressed the production of serum tumor necrosis factor (TNF)-α and interferon (IFN)-γ, alleviated the infiltration of hepatic macrophages, neutrophils, and activated CD4(+) T lymphocytes in Con A-primed mice...
January 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28074952/upregulation-of-caveolin-1-by-mulberry-leaf-extract-and-its-major-components-chlorogenic-acid-derivatives-attenuates-alcoholic-steatohepatitis-via-inhibition-of-oxidative-stress
#3
Yi-Ju Lee, Jeng-Dong Hsu, Wea-Lung Lin, Shao-Hsuan Kao, Chau-Jong Wang
Excessive alcohol uptake exerts hepatocellular toxicity, ultimately leading to multiple liver diseases such as steatohepatitis and liver cirrhosis. Here, we aimed to explore the effects of mulberry leaf extract (MLE) and its major components chlorogenic acid (CGA) and neochlorogenic acid (nCGA) on alcoholic steatohepatitis. We determined the composition of MLE using liquid chromatography-mass spectrometric (LC-MS) analysis, which showed that MLE consisted of mainly chlorogenic acid derivatives and other polyphenols...
January 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28064173/interventions-to-prevent-or-reduce-the-level-of-frailty-in-community-dwelling-older-adults-a-scoping-review-of-the-literature-and-international-policies
#4
REVIEW
Martine T E Puts, Samar Toubasi, Melissa K Andrew, Maureen C Ashe, Jenny Ploeg, Esther Atkinson, Ana Patricia Ayala, Angelique Roy, Miriam Rodríguez Monforte, Howard Bergman, Kathy McGilton
BACKGROUND: frailty impacts older adults' ability to recover from an acute illness, injuries and other stresses. Currently, a systematic synthesis of available interventions to prevent or reduce frailty does not exist. Therefore, we conducted a scoping review of interventions and international policies designed to prevent or reduce the level of frailty in community-dwelling older adults. METHODS AND ANALYSIS: we conducted a scoping review using the framework of Arksey and O'Malley. We systematically searched articles and grey literature to identify interventions and policies that aimed to prevent or reduce the level of frailty...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28049616/three-decades-of-comprehensive-geriatric-assessment-evidence-coming-from-different-healthcare-settings-and-specific-clinical-conditions
#5
REVIEW
Alberto Pilotto, Alberto Cella, Andrea Pilotto, Julia Daragjati, Nicola Veronese, Clarissa Musacchio, Anna Maria Mello, Giancarlo Logroscino, Alessandro Padovani, Camilla Prete, Francesco Panza
Comprehensive geriatric assessment (CGA) is a multidisciplinary diagnostic and treatment process that identifies medical, psychosocial, and functional capabilities of older adults to develop a coordinated plan to maximize overall health with aging. Specific criteria used by CGA programs to evaluate patients include age, medical comorbidities, psychosocial problems, previous or predicted high healthcare utilization, change in living situation, and specific geriatric conditions. However, no universal criteria have been agreed upon to readily identify patients who are likely to benefit from CGA...
December 31, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28043759/baseline-plasma-chromogranin-a-levels-in-patients-with-well-differentiated-neuroendocrine-tumors-of-the-pancreas-a-potential-predictor-of-postoperative-recurrence
#6
Yoshihide Nanno, Hirochika Toyama, Ippei Matsumoto, Kyoko Otani, Sadaki Asari, Tadahiro Goto, Tetsuo Ajiki, Yoh Zen, Takumi Fukumoto, Yonson Ku
BACKGROUND: The present study aimed to elucidate prognostic values of baseline plasma chromogranin A (CgA) concentrations in patients with resectable, well-differentiated pancreatic neuroendocrine tumors (PNETs). METHODS: Preoperative CgA levels in 21 patients with PNET were correlated with clinicopathological factors and patients' survival. RESULTS: Plasma CgA levels ranged 2.9-30.8 pmol/mL (median 6.0), and were significantly elevated in patients with post-operative recurrence (P = 0...
December 29, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28041642/a-genome-wide-association-study-identifies-risk-alleles-in-plasminogen-and-p4ha2-associated-with-giant-cell-arteritis
#7
F David Carmona, Augusto Vaglio, Sarah L Mackie, José Hernández-Rodríguez, Paul A Monach, Santos Castañeda, Roser Solans, Inmaculada C Morado, Javier Narváez, Marc Ramentol-Sintas, Colin T Pease, Bhaskar Dasgupta, Richard Watts, Nader Khalidi, Carol A Langford, Steven Ytterberg, Luigi Boiardi, Lorenzo Beretta, Marcello Govoni, Giacomo Emmi, Francesco Bonatti, Marco A Cimmino, Torsten Witte, Thomas Neumann, Julia Holle, Verena Schönau, Laurent Sailler, Thomas Papo, Julien Haroche, Alfred Mahr, Luc Mouthon, Øyvind Molberg, Andreas P Diamantopoulos, Alexandre Voskuyl, Elisabeth Brouwer, Thomas Daikeler, Christoph T Berger, Eamonn S Molloy, Lorraine O'Neill, Daniel Blockmans, Benedicte A Lie, Paul Mclaren, Timothy J Vyse, Cisca Wijmenga, Yannick Allanore, Bobby P C Koeleman, Jennifer H Barrett, María C Cid, Carlo Salvarani, Peter A Merkel, Ann W Morgan, Miguel A González-Gay, Javier Martín
Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analyzed in 2,134 case subjects and 9,125 unaffected individuals from ten independent populations of European ancestry. Our data confirmed HLA class II as the strongest associated region (independent signals: rs9268905, p = 1...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28031704/is-the-acute-care-of-frail-elderly-patients-in-a-comprehensive-geriatric-assessment-unit-superior-to-conventional-acute-medical-care
#8
Niklas Ekerstad, Björn W Karlson, Synneve Dahlin Ivanoff, Sten Landahl, David Andersson, Emelie Heintz, Magnus Husberg, Jenny Alwin
OBJECTIVE: The aim of this study was to investigate whether the acute care of frail elderly patients in a comprehensive geriatric assessment (CGA) unit is superior to the care in a conventional acute medical care unit. DESIGN: This is a clinical, prospective, randomized, controlled, one-center intervention study. SETTING: This study was conducted in a large county hospital in western Sweden. PARTICIPANTS: The study included 408 frail elderly patients, aged ≥75 years, in need of acute in-hospital treatment...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28029467/-frail-vig-index-design-and-evaluation-of-a-new-frailty-index-based-on-the-comprehensive-geriatric-assessment
#9
Jordi Amblàs-Novellas, Joan Carles Martori, Núria Molist Brunet, Ramon Oller, Xavier Gómez-Batiste, Joan Espaulella Panicot
INTRODUCTION: Frailty is closely linked to health results. Frailty indexes (FI) and the Comprehensive Geriatric Assessment (CGA) are multidimensional tools. FI serve to quantitatively measure frailty levels. They have shown to have an excellent correlation with mortality. However, they are infrequently used in clinical practice. Given the need for new, more concise, and pragmatic FI, a new FI is proposed based on a CGA (Frail-VIG Index). MATERIAL AND METHODS: A prospective, observational, longitudinal study was conducted, with cohort follow up at 12 months or death...
October 28, 2016: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28028753/chlorogenic-acid-attenuates-lipopolysaccharide-induced-acute-kidney-injury-by-inhibiting-tlr4-nf-%C3%AE%C2%BAb-signal-pathway
#10
Han-Yang Ye, Jian Jin, Ling-Wei Jin, Yan Chen, Zhi-Hong Zhou, Zhan-Yuan Li
Chlorogenic acid (CGA), a polyphenolic compound, exists widely in medicinal herbs, which has been shown a strong antioxidant and anti-inflammatory effect. This study investigated the protective effects and mechanism of CGA on lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Treatment of CGA successfully ameliorates LPS-induced renal function and pathological damage. Moreover, CGA dose-dependently suppressed LPS-induced blood urea nitrogen (BUN), creatinine levels, and inflammatory cytokines TNF-α, IL-6, and IL-1β in serum and tissue...
December 27, 2016: Inflammation
https://www.readbyqxmd.com/read/28026127/well-differentiated-bronchial-neuroendocrine-tumors-clinical-management-and-outcomes-in-105-patients
#11
Marinos Pericleous, Anna Karpathakis, Christos Toumpanakis, Heather Lumgair, Jonathan Reiner, Laura Marelli, Christina Thirlwell, Martyn E Caplin
INTRODUCTION: Bronchial neuroendocrine tumors (NETs) are rare tumors representing approximately 20%-30% of all neuroendocrine tumors and 2%-3% of all adult lung cancers. Here, they present a large case series of well-differentiated bronchial NETs with the aim of investigating the behavior of these tumors and long-term outcomes. METHODS: A retrospective review was performed of 105 patients with bronchial NETs managed in a tertiary referral center in the period between January 1998 and January 2012...
December 27, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28012692/mediation-of-coffee-induced-improvements-in-human-vascular-function-by-chlorogenic-acids-and-its-metabolites-two-randomized-controlled-crossover-intervention-trials
#12
Charlotte E Mills, Andreas Flury, Cynthia Marmet, Laura Poquet, Stefano F Rimoldi, Claudio Sartori, Emrush Rexhaj, Roman Brenner, Yves Allemann, Diane Zimmermann, Glenn R Gibson, Don S Mottram, Maria-Jose Oruna-Concha, Lucas Actis-Goretta, Jeremy P E Spencer
BACKGROUND & AIMS: Polyphenol intake has been linked to improvements in human vascular function, although data on hydroxycinnamates, such as chlorogenic acid (CGA) have not yet been studied. We aimed to investigate the impact of coffee intake rich in chlorogenic acid on human vascular function and whether CGAs are involved in potential effects. METHODS: Two acute randomized, controlled, cross-over human intervention trials were conducted. The impact of coffee intake, matched for caffeine but differing in CGA content (89, and 310 mg) on flow-mediated dilatation (FMD) was assessed in 15 healthy male subjects...
November 30, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28012116/serum-chromogranin-a-as-a-complementary-marker-for-the-prediction-of-prostate-cancer-specific-survival
#13
Christian Niedworok, Stephan Tschirdewahn, Henning Reis, Nils Lehmann, Miklós Szücs, Péter Nyirády, Imre Romics, Herbert Rübben, Tibor Szarvas
Better prognostication of clinically localized prostate cancer (PCA) is urgently needed. Former studies using different study end-points provided controversial results regarding the prognostic value of serum chromogranin A (CGA) in clinically localized PCA. However, serum CGA was not tested for correlation with the most significant study end-point of long-term disease-specific survival (DSS). CGA and matrix metalloproteinase-7 (MMP7) levels were measured by the BRAHMS KRYPTOR in two independent patient groups with 127 serum and 110 plasma samples...
December 23, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28009337/wireless-multichannel-electroencephalography-in-the-newborn
#14
Z H Ibrahim, G Chari, S Abdel Baki, V Bronshtein, M R Kim, J Weedon, J Cracco, J V Aranda
OBJECTIVES: First, to determine the feasibility of an ultra-compact wireless device (microEEG) to obtain multichannel electroencephalographic (EEG) recording in the Neonatal Intensive Care Unit (NICU). Second, to identify problem areas in order to improve wireless EEG performance. STUDY DESIGN: 28 subjects (gestational age 24-30 weeks, postnatal age <30 days) were recruited at 2 sites as part of an ongoing study of neonatal apnea and wireless EEG. Infants underwent 8-9 hour EEG recordings every 2-4 weeks using an electrode cap (ANT-Neuro) connected to the wireless EEG device (Bio-Signal Group)...
2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28006693/clinical-implication-of-frailty-assessment-in-older-patients-with-atrial-fibrillation
#15
Sun-Wook Kim, Sol-Ji Yoon, Jung-Yeon Choi, Min-Gu Kang, Youngjin Cho, Il-Young Oh, Cheol-Ho Kim, Kwang-Il Kim
BACKGROUND: We aimed to show the frailty status in older AF patients, and to find the association between frailty and the scores of CHA2DS2-VASc and HAS-BLED. Ultimately, we sought to investigate the impact of frailty on cardiovascular and all-cause mortality in older AF patients. METHODS: We retrospectively evaluated 365 patients (≥65years old) with AF, who underwent comprehensive geriatric assessment (CGA) between 2007 and 2014 in a single tertiary hospital...
December 5, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28003514/s-cerevisiae-trm140-has-two-recognition-modes-for-3-methylcytidine-modification-of-the-anticodon-loop-of-trna-substrates
#16
Lu Han, Erin Marcus, Sonia D'Silva, Eric M Phizicky
The 3-methylcytidine (m3C) modification is ubiquitous in eukaryotic tRNA, widely found at C32 in the anticodon loop of tRNAThr, tRNASer, and some tRNAArg species, as well as in the variable loop (V-loop) of certain tRNASer species. In the yeast Saccharomyces cerevisiae, formation of m3C32 requires Trm140 for six tRNA substrates, including three tRNAThr species and three tRNASer species, whereas in Schizosacchomyces pombe, two Trm140 homologs are employed, one for tRNAThr and one for tRNASer. The occurrence of a single Trm140 homolog is conserved broadly among Ascomycota, whereas multiple Trm140-related homologs are found in metazoans and other fungi...
December 21, 2016: RNA
https://www.readbyqxmd.com/read/28003366/neuroendocrine-cells-of-the-prostate-derive-from-the-neural-crest
#17
Jaroslaw Szczyrba, Anne Niesen, Matthias Wagner, Petra M Wandernoth, Gerhard Aumüller, Gunther Wennemuth
The histogenesis of prostatic neuroendocrine cells is controversial: a stem cell hypothesis with a urogenital sinus-derived progeny of all prostatic epithelial cells is opposed by a dual origin hypothesis, favoring the derivation of neuroendocrine cells from the neural crest whereas the secretory and basal cells being of urogenital sinus origin. A computer-assisted 3D reconstruction was used to analyze the distribution of CGA immunoreactive cells in serial sections of human fetal prostate specimens (gestation weeks 18 and 25)...
December 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27999620/effects-of-escherichia-coli-nissle-1917-and-ciprofloxacin-on-small-intestinal-epithelial-cell-mrna-expression-in-the-neonatal-piglet-model-of-human-rotavirus-infection
#18
Francine C Paim, Stephanie N Langel, David D Fischer, Sukumar Kandasamy, Lulu Shao, Moyasar A Alhamo, Huang-Chi Huang, Anand Kumar, Gireesh Rajashekara, Linda J Saif, Anastasia N Vlasova
We evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in gnotobiotic (Gn) piglets colonized with a defined commensal microflora (DMF) and inoculated with human rotavirus (HRV) that infects IECs. We analyzed mRNA levels of IEC genes for enteroendocrine cells [chromogranin A (CgA)], goblet cells [mucin 2 (MUC2)], transient amplifying progenitor cell [proliferating cell nuclear antigen (PCNA)], intestinal epithelial stem cell (SOX9) and enterocytes (villin)...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27999287/simultaneous-qualitation-and-quantitation-of-chlorogenic-acids-in-kuding-tea-using-ultra-high-performance-liquid-chromatography-diode-array-detection-coupled-with-linear-ion-trap-orbitrap-mass-spectrometer
#19
Yanyun Che, Zhibin Wang, Zhiyun Zhu, Yangyang Ma, Yaqiong Zhang, Wen Gu, Jiayu Zhang, Gaoxiong Rao
Kuding tea, the leaves of Ilex Kudingcha C.J. Tseng, has been applied for treating obesity, hypertension, cardiovascular disease, hyperlipidemia, and so on. The chlorogenic acids (CGAs) in Kuding tea have shown excellent antioxidative, antiobesity, anti-atherosclerotic and anticancer activities. Nevertheless, the chemical profiles of CGAs in Kuding tea have not been comprehensively studied yet, which hinders further quality control. In the present study, a sensitive ultra-high-performance liquid chromatography-diode array detection coupled with a linear ion trap-Orbitrap (UHPLC-DAD-LTQ-Orbitrap) method was established to screen and identify CGAs in Kuding tea...
December 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27988239/contribution-of-clinical-gait-analysis-to-single-event-multi-level-surgery-in-children-with-cerebral-palsy
#20
REVIEW
N Khouri, E Desailly
Clinical gait analysis (CGA) has been proven useful in understanding the gait disturbances seen in children and adolescents with cerebral palsy. Another major benefit provided by CGA is a clinical and scientific evaluation of how orthopaedic surgical procedures modify gait. The information provided by instrumented CGA complements the clinical data, and the two must be interpreted jointly. Although there is some variability in the surgical details of therapeutic strategies, CGA undoubtedly influences the planning of surgery...
November 15, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
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