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https://www.readbyqxmd.com/read/28818778/potential-effect-of-compounds-isolated-from-coffea-arabica-against-uv-b-induced-skin-damage-by-protecting-fibroblast-cells
#1
Yong-Hun Cho, Ashutosh Bahuguna, Han-Hyuk Kim, Dong-In Kim, Hyeon-Jeong Kim, Jae-Myo Yu, Hyun-Gug Jung, Jae-Yoon Jang, Jae-Hoon Kwak, Geun-Hye Park, O-Jun Kwon, Young Je Cho, Jeong Yeon An, Cheorun Jo, Sun Chul Kang, Bong-Jeun An
Ultraviolet (UV) radiation has adverse effects on extracellular matrix (ECM) proteins, leading to formation of wrinkles a hallmark of premature skin aging. The adverse effects of UV radiation are associated with induction of matrix metalloproteinases (MMPs) expression and degradation of collagen and elastin. The present study investigated anti-wrinkle effects of chlorogenic acid (CGA), pyrocatechol (PC) and 3,4,5-tricaffeoyl quinic acid (TCQ), isolated from beans of Coffea arabica, against UV-B stimulated mouse fibroblast cells (CCRF) by measuring expression levels of MMP-1, 3, 9, and type-I procollagen...
August 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28810646/sex-comb-on-midleg-like-2-is-a-novel-specific-marker-for-the-diagnosis-of-gastroenteropancreatic-neuroendocrine-tumors
#2
Jiao-Jiao Yang, Hua Huang, Ming-Bing Xiao, Feng Jiang, Wen-Kai Ni, Yi-Fei Ji, Cui-Hua Lu, Run-Zhou Ni
Sex comb on midleg like-2 (SCML2) is a polycomb-group protein that encodes transcriptional repressors essential for appropriate development in the fly and in mammals. On the basis of previous findings, the present study aimed to explore the possibility of developing SCML2 into a new diagnostic marker for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A total of 64 paired GEP-NET tissues and adjacent non-tumorous tissues were obtained from patients who had undergone surgical resection between January 2009 and January 2014, and the expression of SCML2 and two neuroendocrine markers, namely synaptophysin (Syn) and chromogranin A (CgA), in the tissues was assessed by immunohistochemistry...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28806699/a-portable-synthesis-of-water-soluble-carbon-dots-for-highly-sensitive-and-selective-detection-of-chlorogenic-acid-based-on-inner-filter-effect
#3
Huan Yang, Liu Yang, Yusheng Yuan, Shuang Pan, Jidong Yang, Jingjing Yan, Hui Zhang, Qianqian Sun, Xiaoli Hu
In this work, a simple and facile hydrothermal method for synthesis of water-soluble carbon dots (CDs) with malic acid and urea, and were then employed as a high-performance fluorescent probe for selective and sensitive determination of chlorogenic acid (CGA) based on inner filter effect. The as-synthesized CDs was systematically characterized by Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Energy disperse spectroscopy (EDS), UV-vis absorption spectroscopy, spectrofluorophotometry, and the results indicated that the sizes of CDs were mainly distributed in the range of 1...
August 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28805339/what-happens-in-the-pith-stays-in-the-pith-tissue-localized-defense-responses-facilitate-chemical-niche-differentiation-between-two-spatially-separated-herbivores
#4
Gisuk Lee, Youngsung Joo, Sang-Gyu Kim, Ian T Baldwin
Herbivore attack is known to elicit systemic defense responses that spread throughout the hostplant and influence the performance of other herbivores. While these plant-mediated indirect competitive interactions are well-described, and the co-existence of herbivores from different feeding guilds is common, the mechanisms of co-existence are poorly understood. In both field and glasshouse experiments with a native tobacco, Nicotiana attenuata, we found no evidence of negative interactions when plants were simultaneously attacked by two spatially separated herbivores: a leaf chewer Manduca sexta and a stem borer Trichobaris mucorea...
August 14, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28804908/influence-of-abiraterone-acetate-on-neuroendocrine-differentiation-in-chemotherapy-naive-metastatic-castration-resistant-prostate-cancer
#5
Baijun Dong, Liancheng Fan, Yanqing Wang, Chenfei Chi, Xiaowei Ma, Rui Wang, Wen Cai, Xiaoguang Shao, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Shaowei Xie, Xiaonan Kang, Lixin Zhou, Wei Xue
BACKGROUND: To determine the influence of abiraterone Acetate (AA) on neuroendocrine differentiation (NED) in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC). METHODS: We conducted an analysis in 115 chemotherapy-naïve mCRPC patients who would be treated with chemotherapy. The serum levels of chromogranin A (CgA), neurone-specific enolase (NSE) were measured in 67 mCRPC patients without AA treatment and 48 patients after the failure of AA treatment, in which these markers were also measured in 34 patients before and after 6 months of AA treatment...
August 14, 2017: Prostate
https://www.readbyqxmd.com/read/28797032/comprehensive-geriatric-assessment-in-326-older-women-with-early-breast-cancer
#6
D O Okonji, R Sinha, I Phillips, D Fatz, A Ring
BACKGROUND: One-third of new early breast cancer diagnoses occur in women over 70 years old. However, older women are less likely to receive radical curative treatments. This study prospectively evaluated a cohort of older women using a Comprehensive Geriatric Assessment (CGA) to determine whether fitness explained the apparent under-treatment in this patient group. METHODS: In this multi-centre prospective study, patients aged ⩾70 years with Stages I-III breast cancer underwent a pretreatment baseline CGA consisting of eight assessment tools...
August 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28773198/synthesis-of-bioactive-chlorogenic-acid-silica-hybrid-materials-via-the-sol-gel-route-and-evaluation-of-their-biocompatibility
#7
Michelina Catauro, Severina Pacifico
Natural phenol compounds are gaining a great deal of attention because of their potential use as prophylactic and therapeutic agents in many diseases, as well as in applied science for their preventing role in oxidation deterioration. With the aim to synthetize new phenol-based materials, the sol-gel method was used to embed different content of the phenolic antioxidant chlorogenic acid (CGA) within silica matrices to obtain organic-inorganic hybrid materials. Fourier transform infrared (FTIR) measurements were used to characterize the prepared materials...
July 21, 2017: Materials
https://www.readbyqxmd.com/read/28765414/acute-geriatrics-at-the-front-door
#8
Simon Conroy, Stuart Parker
Older people with frailty and urgent care needs are major uses of health and social care services. Comprehensive geriatric assessment (CGA) is an evidence-based approach to improving their outcomes, as well as improving service outcomes. Geriatricians form a small proportion of the overall workforce and cannot address the population need alone, so all clinicians (doctors, nurses, therapists and so on) need to engage in delivering CGA as a process of care, underpinned by specific competencies - which can be developed...
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28764761/abnormalities-in-ileal-stem-neurogenin-3-and-enteroendocrine-cells-in-patients-with-irritable-bowel-syndrome
#9
Magdy El-Salhy, Odd Helge Gilja
BACKGROUND: This study examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ileum of patients with irritable bowel syndrome (IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities in stem cells and enteroendocrine cell progenitors. METHODS: One hundred and one IBS patients covering all IBS subtypes were recruited, and 39 non-IBS subjects were included as a control group. The patients and controls underwent standard colonoscopies, during which biopsy specimens were obtained from the ileum...
August 1, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28759754/potential-of-the-chlorogenic-acid-as-multitarget-agent-insulin-secretagogue-and-ppar-%C3%AE-%C3%AE-dual-agonist
#10
Maetzin Becerra Sanchez, Elizabeth Miranda-Perez, Juan Carlos Gomez Verjan, Maria de Los Angeles Fortis Barrera, Julia Perez-Ramos, Francisco Javier Alarcon-Aguilar
The chlorogenic acid (CGA) is a natural product isolated from Cecropia obtusifolia, which possesses several pharmacological properties, such as: anti-carcinogenic, neuroprotective, antioxidant, anti-inflammatory, hypoglycemic, and hypolipidemic. In relation to its effects on the hyperglycemia and hypertriglyceridemia, few is known about the mechanisms in which this compound may be acting, therefore, the aim of the present study was to determine if CGA acts as an insulin secretagogue increasing intracellular calcium concentrations ([Ca(2+)]i) in RINm5F cells; or as an insulin sensitizer and lipid-lowering agent stimulating the expression of PPARγ and PPARα, respectively, in 3T3-L1 adipocytes...
July 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28755691/chlorogenic-acid-is-a-fungicide-active-against-phytopathogenic-fungi
#11
Guadalupe Martínez, Mariana Regente, Santiago Jacobi, Marianela Del Rio, Marcela Pinedo, Laura de la Canal
Plants synthesize diverse types of secondary metabolites and some of them participate in plant protection against pathogen attack. These compounds are biodegradable and renewable alternatives, which may be envisaged for the control of plant pests and diseases. Chlorogenic acid (CGA) is a phenolic secondary metabolite which accumulates in diverse plant tissues and can be found in several agro-industrial by-products and waste. The aim of this work was to determine whether CGA could control the growth of various plant pathogenic fungi, gaining insight into its mechanism of action...
August 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28747720/mitochondrial-genomes-of-two-bombycoidea-insects-and-implications-for-their-phylogeny
#12
Zhao-Zhe Xin, Yu Liu, Xiao-Yu Zhu, Ying Wang, Hua-Bin Zhang, Dai-Zhen Zhang, Chun-Lin Zhou, Bo-Ping Tang, Qiu-Ning Liu
The mitochondrial genome (mt genome) provides important information for understanding molecular evolution and phylogenetics. As such, the two complete mt genomes of Ampelophaga rubiginosa and Rondotia menciana were sequenced and annotated. The two circular genomes of A. rubiginosa and R. menciana are 15,282 and 15,636 bp long, respectively, including 13 protein-coding genes (PCGs), two rRNA genes, 22 tRNA genes and an A + T-rich region. The nucleotide composition of the A. rubiginosa mt genome is A + T rich (81...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28746739/characterization-and-influence-of-green-synthesized-of-nano-sized-zinc-complex-with-5-aminolevulinic-acid-on-bioactive-compounds-of-aniseed
#13
Vahid Tavallali, Sadegh Rahmati, Vahid Rowshan
A new water soluble zinc-aminolevulinic acid nano complex (n[Zn(ALA)2 ]), which characterized by TEM, IR and EDX spectra, has been prepared via sonochemical method under green conditions in water. In the current study, the effectiveness of foliar Zn amendment using synthetic Zn-ALA nano complex, as a new introduced Zn-fertilizer here, was evaluated. As the model plant, Pimpinella anisum, the most valuable spice and medicinal plant grown in warm regions, was used. By using zinc nano complex, further twenty compounds were obtained in the essential oil of anise plants...
July 26, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28745369/chlorogenic-acid-protects-against-aluminium-induced-cytotoxicity-through-chelation-and-antioxidant-actions-in-primary-hippocampal-neuronal-cells
#14
Xiaomei Wang, Xinguang Fan, Shuzhi Yuan, Wenxiao Jiao, Bangdi Liu, Jiankang Cao, Weibo Jiang
Chlorogenic acid (CGA), a major polyphenolic component of many plants, displays antioxidant and neuroprotective properties in neurodegenerative diseases. To investigate whether CGA may influence aluminium (Al) induced cytotoxicity, aluminium chloride (50 μM Al) was administered in primary hippocampal neuronal cells presupplemented with CGA (10, 50 and 100 μM). Our study shows that the exposure to Al caused cell death, Al(3+) accumulation, reactive oxygen species generation and mitochondrial damage in cells...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28739749/analysis-of-clinicopathological-features-and-prognostic-factors-in-39-cases-of-bladder-neuroendocrine-carcinoma
#15
Hui-Hui Zhou, Li-Yan Liu, Guo-Hua Yu, Gui-Mei Qu, Pei-You Gong, Xiao Yu, Ping Yang
AIM: Through analysis and summarization of clinicopathological features, immunohistochemical expression, pathological diagnostic criteria, prognostic and other factors in patients suffering from bladder neuroendocrine carcinoma (BNEC), a better understanding of BNEC could be achieved to provide solid evidence for clinicopathology and prognosis. MATERIALS AND METHODS: The clinicopathological data of 39 cases of BNEC with up to 5-year follow-up data (median follow-up=650 days) were analyzed retrospectively based on immunohistochemical staining...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739158/assessment-and-management-of-radiotherapy-induced-toxicity-in-older-patients
#16
Anita O'Donovan, Michelle Leech, Charles Gillham
Radiotherapy is an attractive treatment option for older adults, especially where surgery and chemotherapy pose too great a risk. Radiotherapy toxicity may be divided into acute/early and late effects of treatment. The latter may have limited relevance to an older patient with competing causes of mortality due to significant comorbidity. Altered fractionation regimes have been employed in numerous sites, with no significant toxicity impact. These offer greater convenience in the elderly, especially those with limited social support or in active caregiving roles...
July 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28738329/distinct-involvement-of-the-sonic-hedgehog-signaling-pathway-in-gastric-adenocarcinoma-of-fundic-gland-type-and-conventional-gastric-adenocarcinoma
#17
Yuzuru Tajima, Takashi Murakami, Tsuyoshi Saito, Takafumi Hiromoto, Yoichi Akazawa, Noriko Sasahara, Hiroyuki Mitomi, Takashi Yao, Sumio Watanabe
BACKGROUND/AIMS: Gastric adenocarcinoma of fundic gland type (GAFG), which is a rare variant of gastric cancer, is reportedly associated with both Wnt/β-catenin signaling activation and guanine nucleotide binding protein, alpha stimulating complex (GNAS) mutations. This study aimed to elucidate potential roles of the Sonic hedgehog (Shh) signaling pathway in GAFG. METHODS: We performed immunostaining for β-catenin and Shh signal-associated proteins, including Patched (Ptch), Smoothened (Smo), and Glioma-associated oncogene-1 (Gli1), and the direct sequencing of GNAS/BRAF/KRAS in 27 GAFGs, and compared them with 30 conventional gastric adenocarcinomas (CGAs)...
July 22, 2017: Digestion
https://www.readbyqxmd.com/read/28721067/phase-i-dose-escalation-study-of-long-acting-pasireotide-in-patients-with-neuroendocrine-tumors
#18
James C Yao, Jennifer A Chan, Alain C Mita, Madan G Kundu, Karina Hermosillo Reséndiz, Ke Hu, Shoba Ravichandran, Jonathan R Strosberg, Edward M Wolin
This phase I study aimed at determining the maximum tolerated dose (MTD) and characterizing the safety, tolerability, pharmacokinetics (PKs), and efficacy of pasireotide in patients with advanced neuroendocrine tumors (NETs). Patients were enrolled in two phases: dose-escalation phase (to determine the MTD) at a starting dose of 80 mg pasireotide long-acting release (LAR) i.m. followed by a dose-expansion phase (to evaluate safety and prelimi-nary efficacy). Associations between PK/pharmacodynamic parameters and clinical outcomes were evaluated using linear regression analysis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28721031/operationalizing-a-frailty-index-using-routine-blood-and-urine-tests
#19
Martin Ritt, Jakob Jäger, Julia Isabel Ritt, Cornel Christian Sieber, Karl-Günter Gaßmann
BACKGROUND: Uncomplicated frailty instruments are desirable for use in a busy clinical setting. The aim of this study was to operationalize a frailty index (FI) from routine blood and urine tests, and to evaluate the properties of this FI compared to other frailty instruments. MATERIALS AND METHODS: We conducted a secondary analysis of a prospective cohort study on 306 patients aged ≥65 years hospitalized on geriatric wards. An FI comprising 22 routine blood parameters and one standard urine parameter (FI-Lab), a 50-item FI based on a comprehensive geriatric assessment (FI-CGA), a combined FI (FI-combined [items from the FI-Lab + others from the FI-CGA]), the Clinical Frailty Scale, rule-based frailty definition, and frailty phenotype were operationalized from data obtained during patients' hospital stays (ie, before discharge [baseline examination])...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28720938/effect-of-green-coffee-extract-on-rheological-physico-sensory-and-antioxidant-properties-of-bread
#20
A Mukkundur Vasudevaiah, A Chaturvedi, R Kulathooran, I Dasappa
Green coffee extract, GCE (Coffee canephora) was used at 1.0, 1.5 and 2.0% levels for making bioactive rich bread. The processed GCE from the green coffee beans had 21.42% gallic acid equivalents (GAE) total polyphenols (TPP), 37.28% chlorogenic acid (CGA) and 92.73% radical scavenging activity (RSA), at 100 ppm concentration of GCE and caffeine content (1.75%). Rheological, physico-sensory and antioxidant properties of GCE incorporated breads were analysed and compared with control bread. The results revealed not much significant change in the rheological characteristics of dough up to 1...
June 2017: Journal of Food Science and Technology
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