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https://www.readbyqxmd.com/read/29472376/clinical-relevance-of-different-who-grade-3-pancreatic-neuroendocrine-neoplasms-based-on-morphology
#1
Xu Han, Xuefeng Xu, Hongyun Ma, Yuan Ji, Dansong Wang, Tiantao Kuang, Wenchuan Wu, Bin Song, Gang Li, Gang Jin, Wenhui Lou
PURPOSE: Emerging evidence suggests G3 pancreatic neuroendocrine neoplasms (pNENs) present heterogeneous morphology and biology. The 2017 WHO classification has introduced a new category of well-differentiated pancreatic neuroendocrine tumors (WD-pNETs) G3, compared with poorly differentiated pancreatic neuroendocrine carcinomas (PD-pNECs) G3. We aim to analysis the demographics and outcomes of patients with resectable 2017 WHO G3 pNENs to facilitate the distinction between two entities...
February 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29467572/prevalence-of-geriatric-syndromes-among-people-aged-65-years-and-older-at-four-community-clinics-in-moscow
#2
Olga N Tkacheva, Nadezda K Runikhina, Valentina S Ostapenko, Natalia V Sharashkina, Elen A Mkhitaryan, Julia S Onuchina, Sergei N Lysenkov, Nikolai N Yakhno, Yan Press
Background: Geriatric syndromes (GSs) are common in older adults and have a significant effect on their quality of life, disability, and use of health care resources. Few studies have assessed the prevalence of GSs in Russia. The aim of this study is to assess the prevalence of GSs among older adults living in the community in Moscow. Methods: A cross-sectional study was conducted in four community clinics in Moscow. A total of 1,220 patients completed a screening questionnaire, and 356 of them also underwent a comprehensive geriatric assessment (CGA)...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29462677/characterization-of-the-complete-mitochondrial-genome-of-biston-marginata-lepidoptera-geometridae-and-phylogenetic-analysis-among-lepidopteran-insects
#3
Nan Zheng, Yu-Xuan Sun, Liang-Li Yang, Liang Wu, Muhammad Nadeem Abbas, Chen Chen, Jin Gao, Xiao-Kun Li, Chao-Liang Liu, Li-Shang Dai
The complete mitochondrial genome (mitogenome) of Biston marginata (Lepidoptera: Geometridae) was determined and annotated. The circular genome is 15,470 bp long and it contains the entire set of 37 genes usually present in lepidopteran mitogenomes. The nucleotide composition of the genome is highly A + T biased, accounting for 81.20%, with a slightly positive AT skewness (0.028), indicating the occurrence of more As than Ts, as found in other Geometridae species. Except for cox1 gene starts with non-canonical initial codon CGA, all protein-coding genes start with ATN codon...
February 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29448875/screening-for-cognitive-impairment-in-an-australian-aged-care-assessment-team-as-part-of-comprehensive-geriatric-assessment
#4
Roger Clarnette, Ming Goh, Sneha Bharadwaj, Jillian Ryan, Suzanne Ellis, Anton Svendrovski, D William Molloy, Rónán O'Caoimh
Accurate detection of mild cognitive impairment (MCI) is important to stratify and address risk. Yet, few short cognitive screening instruments are validated for this. . In Australia, all clients referred to an Aged Care Assessment Team (ACAT) receive comprehensive geriatric assessment (CGA) including the Standardized Mini-Mental State Examination (SMMSE). We compared the accuracy of the quick mild cognitive impairment (Qmci) screen to the SMMSE in 283 participants: 195 with dementia, 47 with MCI, and 41 with subjective cognitive decline (SCD) in an Australian community-based ACAT...
February 15, 2018: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/29446038/preoperative-evaluation-of-the-elderly-surgical-patient-and-anesthesia-challenges-in-the-xxi-century
#5
Gabriella Bettelli
Universally recognized goals of preoperative anesthesia assessment are the evaluation of patient's health status to define the entity of the surgical risk, and the anticipation of possible complications while optimizing and planning preventive strategies. Data obtained by Comprehensive Geriatric Assessment (CGA) and frailty evaluation are of extreme usefulness in surgical risk evaluation in older patients and in the decision about surgery. It is from the team-based discussion of such results that the most appropriate treatment can be individuated, surgery invasiveness and duration critically analyzed and if needed modified, and the best perioperative strategy carefully tailored...
February 14, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29445266/are-frail-elderly-patients-treated-in-a-cga-unit-more-satisfied-with-their-hospital-care-than-those-treated-in-conventional-acute-medical-care
#6
Niklas Ekerstad, Göran Östberg, Maria Johansson, Björn W Karlson
Objectives: Our aim was to study whether the acute care of frail elderly patients directly admitted to a comprehensive geriatric assessment (CGA) unit is superior to the care in a conventional acute medical care unit in terms of patient satisfaction. Design: TREEE (Is the TReatment of frail Elderly patients Effective in an Elderly care unit?) is a clinical, prospective, controlled, one-center intervention trial comparing acute treatment in CGA units and in conventional wards...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29444629/canine-clitoral-carcinoma-a-clinical-cytologic-histopathologic-immunohistochemical-and-ultrastructural-study
#7
Ranieri Verin, Francesco Cian, Jennifer Stewart, Diana Binanti, Amy L MacNeill, Martina Piviani, Paola Monti, Gianna Baroni, Sophie Le Calvez, Timothy J Scase, Riccardo Finotello
Vaginal and vulvar tumors are uncommon in dogs. Knowledge of canine primary clitoral neoplasia is restricted to a few case reports, and only carcinomas have been reported. Cytologic and histologic features reported in the literature seem to overlap with those of canine apocrine gland anal sac adenocarcinoma (AGASA). Clinical features also recall those of canine AGASA, such as locoregional metastases and hypercalcemia of malignancy (HM). In this study, 6 cases of primary canine clitoral carcinomas (CCCs), with and without HM, were investigated by means of cytology, histopathology, electron microscopy, and immunohistochemistry for neuroendocrine markers including chromogranin A (CGA), synaptophysin (SYN), neuron-specific enolase (NSE), and S-100...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29436734/risk-of-malnutrition-evaluated-by-mini-nutritional-assessment-and-sarcopenia-in-noninstitutionalized-elderly-people
#8
Ilaria Liguori, Francesco Curcio, Gennaro Russo, Michele Cellurale, Luisa Aran, Giulia Bulli, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
BACKGROUND: Malnutrition indices and muscle mass and strength in the elderly are poorly investigated. Moreover, malnutrition seems to be 1 of the more important factors in the cause of sarcopenia. The presence of sarcopenia and its relationship with malnutrition indices were studied in noninstitutionalized elderly people who underwent Comprehensive Geriatric Assessment (CGA). METHODS: A total of 473 elderly subjects (mean age, 80.9 ± 6.6 years) admitted to CGA were studied...
February 13, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29433216/effect-of-altitude-on-biochemical-composition-and-quality-of-green-arabica-coffee-beans-can-be-affected-by-shade-and-postharvest-processing-method
#9
Mohammed Worku, Bruno de Meulenaer, Luc Duchateau, Pascal Boeckx
Although various studies have assessed altitude, shade and postharvest processing effects on biochemical content and quality of coffee beans, data on their interactions are scarce. The individual and interactive effects of these factors on the caffeine, chlorogenic acids (CGA) and sucrose contents as well as physical and sensory qualities of green coffee beans from large plantations in southwestern Ethiopia were evaluated. Caffeine and CGA contents decreased with increasing altitude; they respectively declined 0...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29432123/catestatin-inhibits-obesity-induced-macrophage-infiltration-and-inflammation-in-the-liver-and-suppresses-hepatic-glucose-production-leading-to-improved-insulin-sensitivity
#10
Wei Ying, Sumana Mahata, Gautam K Bandyopadhyay, Zhenqi Zhou, Joshua Wollam, Jessica Vu, Rafael Mayoral, Nai-Wen Chi, Nicholas J G Webster, Angelo Corti, Sushil K Mahata
The activation of Kupffer cells (KCs) and monocyte (Mc)-derived recruited macrophages (McMΦs) in the liver contributes to obesity-induced insulin resistance and type 2 diabetes. Diet-induced obese (DIO) mice treated with Chromogranin A (CgA) peptide catestatin (CST) showed several positive results. These included decreased hepatic/plasma lipids and plasma insulin, diminished expression of gluconeogenic genes, attenuated expression of pro-inflammatory genes, increased expression of anti-inflammatory genes in McMΦs, and inhibition of the infiltration of McMΦs resulting in improvement of insulin sensitivity...
February 6, 2018: Diabetes
https://www.readbyqxmd.com/read/29429119/the-development-of-a-new-tool-for-the-evaluation-of-handicap-in-elderly-the-geriatric-handicap-scale-ghs
#11
Walter Verrusio, Alessia Renzi, Giulia Spallacci, Maria Tecla Pecci, Maria Antonella Pappadà, Mauro Cacciafesta
BACKGROUND: To date, the comprehensive geriatric assessment (CGA) does not include an evaluation tool for handicap. AIM: To develop a new instrument for assessing handicap in the elderly: the Geriatric Handicap Scale (GHS). METHODS: 656 community-dwelling elderly were enrolled in this study. We identified the thematic areas investigated by the CGA which showed a significant correlation with the handicap condition (handicap yes/not) to be included in our scale (Phase 1)...
February 10, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29425657/urine-metabolomics-shows-an-induction-of-fatty-acids-metabolism-in-healthy-adult-volunteers-after-supplementation-with-green-coffee-coffea-robusta-l-bean-extract
#12
Gregorio Peron, Davide Santarossa, Dario Voinovich, Stefano Dall'Acqua, Stefania Sut
BACKGROUND AND OBJECTIVE: Green coffee bean extract is used as herbal medicine or supplement for weight reduction and obesity. The active constituents are considered caffeine and chlorogenic acid (CGA) derivatives. The mode of action of CGA is still unclear and can be related to peroxisome proliferator-activated receptor α (PPAR-α) and liver X receptor Rα (LXR-α). Metabolomics may be an innovative tool for the description and discovery of the multiple target nature of such phytocomplex...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29423259/comprehensive-geriatric-assessment-pilot-of-a-randomized-control-study-in-a-swedish-acute-hospital-a-feasibility-study
#13
Theresa Westgård, Isabelle Ottenvall Hammar, Eva Holmgren, Anna Ehrenberg, Aase Wisten, Anne W Ekdahl, Synneve Dahlin-Ivanoff, Katarina Wilhelmson
Background: Comprehensive geriatric assessment (CGA) represent an important component of geriatric acute hospital care for frail older people, secured by a multidisciplinary team who addresses the multiple needs of physical health, functional ability, psychological state, cognition and social status. The primary objective of the pilot study was to determine feasibility for recruitment and retention rates. Secondary objectives were to establish proof of principle that CGA has the potential to increase patient safety...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29413048/distinct-clinicopathologic-features-genomic-characteristics-and-survival-of-central-and-peripheral-pulmonary-large-cell-neuroendocrine-carcinoma-from-different-origin-cells
#14
Fei Zhou, Likun Hou, Ting Ding, Quanming Song, Xiaoxia Chen, Chunxia Su, Wei Li, Guanghui Gao, Shengxiang Ren, Fengying Wu, Jiang Fan, Chunyan Wu, Jie Zhang, Caicun Zhou
BACKGROUND: Pulmonary large cell neuroendocrine carcinoma (LCNEC) represents a rare entity in lung cancer with dismal prognosis. In the present study, we investigated whether there are significant differences between central and peripheral tumors of LCNEC, in terms of clinicopathologic features, genomic profiles, and survival. METHODS AND MATERIALS: A total of 126 cases of LCNEC were included. The tumors with invasion of the segmental and/or lobar bronchus were classified as central LCNEC and those without as peripheral LCNEC...
February 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29411331/association-of-pre-operative-medication-use-with-post-surgery-mortality-and-morbidity-in-oncology-patients-receiving-comprehensive-geriatric-assessment
#15
Kyung Suk Choi, Young Mi Jeong, Eunsook Lee, Kwang Ill Kim, Jeong Yee, Byung Koo Lee, Jee Eun Chung, Sandy Jeong Rhie, Hye Sun Gwak
BACKGROUND: Comprehensive geriatric assessment (CGA) has become a predictor for elderly cancer patients in post-surgical complications, including post-discharge institutionalization and mortality. AIMS: To determine whether pre-operative medication use is associated with post-operative morbidity and mortality in oncology patients receiving CGA. METHODS: Patients aged 65 years or older who were scheduled for cancer surgery and presented for CGA were included in the present study...
February 6, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29408518/a-chlorogenic-acid-phospholipid-complex-ameliorates-post-myocardial-infarction-inflammatory-response-mediated-by-mitochondrial-reactive-oxygen-species-in-samp8-mice
#16
Yi Li, Xuecong Ren, Chonkit Lio, Wenxia Sun, Ke Lai, Yuan Liu, Zhifeng Zhang, Jie Liang, Hua Zhou, Liang Liu, Jing Ren, Pei Luo
Mitochondrial reactive oxygen species (mtROS) directly stimulate the inflammatory cytokines cascades and participate in age-related changes of cardiovascular diseases. Application of small molecule targeting the mtROS is significant towards development of better therapy to combat inflammatory response after myocardial infarction (MI) in the aging heart. Chlorogenic acid (CGA) is a well-known natural compound while the clinical potential is largely stifled by its poor oral absorption. In the present study, we tested the protective effect of a novel chlorogenic acid-phospholipid complex (CGA-PC) against acute post-MI inflammation in aged senescence accelerated mouse model...
February 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29404535/cervical-gland-area-as-an-ultrasound-marker-for-prediction-of-preterm-delivery-a-cohort-study
#17
Vajiheh Marsoosi, Reihaneh Pirjani, Mohamad Asghari Jafarabadi, Mina Mashhadian, Saeedeh Ziaee, Ashraf Moini
Background: Preterm labor is a major cause of perinatal morbidity and mortality and it might be predicted by assessing the cervical change. Objective: To assess the association between absence of cervical gland area (CGA) and spontaneous preterm labor (SPTL). Materials and Methods: This prospective cohort study was performed on 200 singleton pregnant women with a history of SPTL, second-trimester abortion in the previous pregnancy or lower abdominal pain in current pregnancy...
November 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29386007/cost-effectiveness-of-comprehensive-geriatric-assessment-at-an-ambulatory-geriatric-unit-based-on-the-age-fit-trial
#18
Martina Lundqvist, Jenny Alwin, Martin Henriksson, Magnus Husberg, Per Carlsson, Anne W Ekdahl
BACKGROUND: Older people with multi-morbidity are increasingly challenging for today's healthcare, and novel, cost-effective healthcare solutions are needed. The aim of this study was to assess the cost-effectiveness of comprehensive geriatric assessment (CGA) at an ambulatory geriatric unit for people ≥75 years with multi-morbidity. METHOD: The primary outcome was the incremental cost-effectiveness ratio (ICER) comparing costs and quality-adjusted life years (QALYs) of a CGA strategy with usual care in a Swedish setting...
January 31, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29385235/comprehensive-geriatric-assessment-for-older-people-admitted-to-a-surgical-service
#19
REVIEW
Gilgamesh Eamer, Amir Taheri, Sidian S Chen, Quinn Daviduck, Thane Chambers, Xinzhe Shi, Rachel G Khadaroo
BACKGROUND: Aging populations are at increased risk of postoperative complications. New methods to provide care for older people recovering from surgery may reduce surgery-related complications. Comprehensive geriatric assessment (CGA) has been shown to improve some outcomes for medical patients, such as enabling them to continue living at home, and has been proposed to have positive impacts for surgical patients. CGA is a coordinated, multidisciplinary collaboration that assesses the medical, psychosocial and functional capabilities and limitations of an older person, with the goal of establishing a treatment plan and long-term follow-up...
January 31, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29384336/assessing-self-reported-green-tea-and-coffee-consumption-by-food-frequency-questionnaire-and-food-record-and-their-association-with-polyphenol-biomarkers-in-japanese-women
#20
Ryusuke Takechi, Helman Alfonso, Amy Harrison, Naoko Hiramatsu, Akari Ishisaka, Akira Tanaka, La'Belle Tan, Andy H Lee
BACKGROUND AND OBJECTIVES: Despite the demonstrated protective effects of green tea and coffee intake against several chronic diseases, finding between studies have not been consistent. One potential reason of this discrepancy is the imprecision in the measurement of tea or coffee consumption using food frequency questionnaire (FFQ) and food record (FR) in epidemiological studies. METHODS AND STUDY DESIGN: In a sample of 57 healthy Japanese women, intake of green tea and coffee was estimated by a validated FFQ and a 3-day FR, while their plasma and urine concentrations of polyphenol biomarkers were measured by HPLC...
2018: Asia Pacific Journal of Clinical Nutrition
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