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https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#1
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29021958/complete-mitochondrial-genome-sequence-of-fruit-piercing-moth-eudocima-phalonia-linnaeus-1763-lepidoptera-noctuoidea
#2
Kuppusamy Sivasankaran, Pratheesh Mathew, Sekar Anand, Stanislaus Antony Ceasar, Soosaimanikam Mariapackiam, Savarimuthu Ignacimuthu
The complete mitochondrial genome of the fruit piercing moth Eudocima phalonia (Linnaeus, 1763) (Lepidoptera: Noctuoidea) was sequenced and characterized (Genbank Accession No: KY196412). The complete mitogenome is a circular molecule of 15,575 bp length, consisting of 13 protein-coding genes (PCGs), two ribosomal RNA genes (rrnS and rrnL), 22 transfer RNA (tRNA) genes and an A + T-rich region (D-loop). The nucleotide composition of the genome is highly A + T biased, accounting for 80.67% of nucleotides...
December 2017: Genomics Data
https://www.readbyqxmd.com/read/29020661/preparation-and-antibacterial-activities-of-chitosan-gallic-acid-polyvinyl-alcohol-blend-film-by-led-uv-irradiation
#3
Soon-Do Yoon, Young-Mog Kim, Boo Il Kim, Jae-Young Je
Active blend films from chitosan-gallic acid (CGA) and polyvinyl alcohol (PVA) were prepared via a simple mixing and casting method through the addition of citric acid as a plasticizer. The CGA/PVA blend films were characterized using Fourier transform infrared spectroscopy (FT-IR). The mechanical properties including tensile strength (TS) and elongation at break (%E), degree of solubility (S) and swelling behavior (DS), water vapor adsorption, and antimicrobial activities of the CGA/PVA blend films with and without LED (light emitting diode)-UV irradiation were also investigated...
September 29, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29018988/circulating-chromogranin-a-and-its-fragments-as-diagnostic-and-prognostic-disease-markers
#4
REVIEW
Angelo Corti, Fabrizio Marcucci, Tiziana Bachetti
Chromogranin A (CgA), a secretory protein released in the blood by neuroendocrine cells and neurons, is the precursor of various bioactive fragments involved in the regulation of the cardiovascular system, metabolism, innate immunity, angiogenesis, and tissue repair. After the original demonstration that circulating CgA can serve as a biomarker for a wide range of neuroendocrine tumors, several studies have shown that increased levels of CgA can be present also in the blood of patients with cardiovascular, gastrointestinal, and inflammatory diseases with, in certain cases, important diagnostic and prognostic implications...
October 10, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29018069/using-comprehensive-geriatric-assessment-for-quality-improvements-in-healthcare-of-older-people-in-uk-care-homes-protocol-for-realist-review-within-proactive-healthcare-of-older-people-in-care-homes-peach-study
#5
Maria Zubair, Neil H Chadborn, John R F Gladman, Tom Dening, Adam L Gordon, Claire Goodman
INTRODUCTION: Care home residents are relatively high users of healthcare resources and may have complex needs. Comprehensive geriatric assessment (CGA) may benefit care home residents and improve efficiency of care delivery. This is an approach to care in which there is a thorough multidisciplinary assessment (physical and mental health, functioning and physical and social environments) and a care plan based on this assessment, usually delivered by a multidisciplinary team. The CGA process is known to improve outcomes for community-dwelling older people and those in receipt of hospital care, but less is known about its efficacy in care home residents...
October 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28992063/the-evolutionary-history-of-saccharomyces-species-inferred-from-completed-mitochondrial-genomes-and-revision-in-the-yeast-mitochondrial-genetic-code
#6
Pavol Sulo, Dana Szabóová, Peter Bielik, Silvia Poláková, Katarína Šoltys, Katarína Jatzová, Tomáš Szemes
The yeast Saccharomyces are widely used to test ecological and evolutionary hypotheses. A large number of nuclear genomic DNA sequences are available, but mitochondrial genomic data are insufficient. We completed mitochondrial DNA (mtDNA) sequencing from Illumina MiSeq reads for all Saccharomyces species. All are circularly mapped molecules decreasing in size with phylogenetic distance from Saccharomyces cerevisiae but with similar gene content including regulatory and selfish elements like origins of replication, introns, free-standing open reading frames or GC clusters...
June 15, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28987891/surface-modified-microbubbles-colloidal-gas-aphrons-for-nanoparticle-removal-in-a-continuous-bubble-generation-flotation-separation-system
#7
Ming Zhang, Pascal Guiraud
The treatment of nanoparticle (NP) polluted aqueous suspensions by flotation can be problematic due to the low probability of collision between particles and bubbles. To overcome this limitation, the present work focuses on developing an enhanced flotation technique using the surface-functionalized microbubbles - colloidal gas aphrons (CGAs). The CGA generator was adapted to be air flow rate controlled based on the classical Sebba system; thus it could be well adopted in a continuous flotation process. Cetyl trimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) were employed for CGA creation...
September 28, 2017: Water Research
https://www.readbyqxmd.com/read/28985882/economic-evaluations-of-comprehensive-geriatric-assessment-in-surgical-patients-a-systematic-review
#8
Gilgamesh Eamer, Bianka Saravana-Bawan, Brenden van der Westhuizen, Thane Chambers, Arto Ohinmaa, Rachel G Khadaroo
BACKGROUND: Seniors presenting with surgical disease face increased risk of postoperative morbidity and mortality and have increased treatment costs. Comprehensive Geriatric Assessment (CGA) is proposed to reduce morbidity, mortality, and the cost after surgery. METHODS: A systematic review of CGA in emergency surgical patients was conducted. The primary outcome was cost-effectiveness; secondary outcomes were length of stay, return of function, and mortality. Inclusion and exclusion criteria were predefined...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28983384/reversing-frailty-levels-in-primary-care-using-the-cares-model
#9
Olga Theou, Grace H Park, Antonina Garm, Xiaowei Song, Barry Clarke, Kenneth Rockwood
BACKGROUND: The purpose of this manuscript was to evaluate the effectiveness of the Community Actions and Resources Empowering Seniors (CARES) model in measuring and mitigating frailty among community-dwelling older adults. METHODS: The CARES model is based on a goal-oriented multidisciplinary primary care plan which combines a comprehensive geriatric assessment (CGA) with health coaching. A total of 51 older adults (82 ± 7 years; 33 females) participated in the pilot phase of this initiative...
September 2017: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/28980157/expression-of-the-cholecystokinin-b-receptor-in-neoplastic-gastric-cells
#10
Patricia Mjønes, Ivar S Nordrum, Øystein Sørdal, Liv Sagatun, Reidar Fossmark, Arne Sandvik, Helge L Waldum
Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In addition to Helicobacter pylori gastritis, gastrin is considered an important factor in the development of this disease, and thus, cholecystokinin-B receptor (CCKBR) becomes of interest. The aim of our study was to explore whether CCKBR is expressed in stomach cancers. Thirty-seven tumors from 19 men and 18 women diagnosed with either adenocarcinoma or neuroendocrine neoplasm (NENs) were included in this study...
October 4, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28971292/using-geriatric-assessment-strategies-to-lead-end-of-life-care-discussions
#11
REVIEW
Ashley Baronner, Amy MacKenzie
End-of-life discussions with geriatric oncology patients are a vital part of the comprehensive care of the senior adult patient. Developing a roadmap for these conversations can be challenging. Patients and caregivers may have expectations that are not concordant with what is reasonably achievable if the patient is frail. Measuring baseline cognition, nutritional status, and physical function and discussing goals of care are all essential pieces of information that can be obtained through a comprehensive geriatric assessment (CGA)...
October 2, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28964828/towards-a-biological-geriatric-assessment
#12
REVIEW
Camilla S L Tuttle, Andrea B Maier
The aging process occurs gradually, is highly individual, with a high degree of inter and intra-individual differences. As such, within an aging population there is significant variation in regards to extent of age related disease and functional impairment. This variability between individuals is thought to be expressed as biological age. Currently, the comprehensive geriatric assessment (CGA), a multidimensional, interdisciplinary diagnostic process is used to determine an individual's medical, psychological and functional capability at older age...
September 27, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28964634/synthesis-biological-evaluation-and-metabolic-stability-of-chlorogenic-acid-derivatives-possessing-thiazole-as-potent-inhibitors-of-%C3%AE-msh-stimulated-melanogenesis
#13
Hyeju Jo, Yuanyuan Zhou, Mayavan Viji, Minho Choi, Jae Young Lim, Jaeuk Sim, Jeongtae Rhee, Youngsoo Kim, Seung-Yong Seo, Wun-Jae Kim, Jin Tae Hong, Heesoon Lee, Kiho Lee, Jae-Kyung Jung
A series of catechol and dioxolane analogs containing thiazole CGA derivatives have been synthesized and evaluated for their inhibitory activity against α-MSH. The inhibitory activity was improved by replacing an α,β-unsaturated carbonyl of previously reported caffeamides with thiazole motif. Surprisingly, compound 7d, one of the derivatives of dioxolane analogs, displayed the most potent inhibitory activity with an IC50 of 0.90μM. Further studies on metabolic stability and bioactivation potential were also accomplished...
September 21, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28963282/the-potential-clinical-benefits-of-medicines-optimisation-through-comprehensive-geriatric-assessment-carried-out-by-secondary-care-geriatricians-in-a-general-practice-care-setting-in-north-staffordshire-uk-a-feasibility-study
#14
Simon Christian Lea, Keira Louise Watts, Nathan Ashley Davis, Barnabas Panayiotou, Michael John Bankart, Amit Arora, Ruth Chambers
OBJECTIVES: To evaluate the feasibility and potential clinical benefits of medicines optimisation through comprehensive geriatric assessment (CGA) of frail patients with multiple conditions, by secondary care geriatricians in a general practice care setting. METHODS: Seven general practitioner (GP) practices in one region of Stoke-on-Trent volunteered to take part. GPs selected patients (n=186) who were local permanent residents, at least 65 years old and on eight or more medications per day...
September 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28962847/complete-sequence-and-characterization-of-the-ectropis-oblique-mitochondrial-genome-and-its-phylogenetic-implications
#15
Li-Shang Dai, Saima Kausar, Muhammad Nadeem Abbas, Tian-Tian Wang
In the present study, we sequenced the entire mitochondrial genome (mitogenome) of Ectropis oblique using PCR amplification and sequencing methods The entire mitogenome is 15,356bp long, including 13 protein coding genes, 22 transfer RNA (tRNA) genes, two ribosomal RNA (rRNA) genes and A+T rich element. The base composition and gene arrangement are identical to those of other lepidopterans. Of these 37 genes, twenty three are resided on heavy strand, while fourteen located on light strand. The newly sequenced mitogenome displayed a biased Adenine/thymine 84...
September 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28958666/pearls-of-optimizing-nutrition-and-physical-performance-of-older-adults-undergoing-cancer-therapy
#16
Antonio Vigano, Popi Kasvis, Jonathan Di Tomasso, Chelsia Gillis, Robert Kilgour, Franco Carli
As the global population continues to age, the prevalence of cancer is increasing, with more than half of new cancer diagnoses occurring in those aged 65years and older. As a result of improved oncological care, a greater number of older patients undergo treatment, either chemoradiotherapy or surgery or both. The older oncology patient is not part of a homogenous group; chronological age poorly describes the health status of an individual. Comprehensive geriatric assessment (CGA) identifies domains, assessed by a multidisciplinary team, that should be considered to guide appropriate oncological treatment decisions...
September 22, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28956082/enteroendocrine-k-and-l-cells-in-healthy-and-type-2-diabetic-individuals
#17
Tina Jorsal, Nicolai A Rhee, Jens Pedersen, Camilla D Wahlgren, Brynjulf Mortensen, Sara L Jepsen, Jacob Jelsing, Louise S Dalbøge, Peter Vilmann, Hazem Hassan, Jakob W Hendel, Steen S Poulsen, Jens J Holst, Tina Vilsbøll, Filip K Knop
AIMS/HYPOTHESIS: Enteroendocrine K and L cells are pivotal in regulating appetite and glucose homeostasis. Knowledge of their distribution in humans is sparse and it is unknown whether alterations occur in type 2 diabetes. We aimed to evaluate the distribution of enteroendocrine K and L cells and relevant prohormone-processing enzymes (using immunohistochemical staining), and to evaluate the mRNA expression of the corresponding genes along the entire intestinal tract in individuals with type 2 diabetes and healthy participants...
September 28, 2017: Diabetologia
https://www.readbyqxmd.com/read/28951438/novel-aspects-of-t3-actions-on-gh-and-tsh-synthesis-and-secretion-physiological-implications
#18
Paula Bargi-Souza, Francemilson Goulart-Silva, Maria Tereza Nunes
Thyroid hormones (TH) classically regulate gene expression by transcriptional mechanisms. In pituitary, the encoding genes for Growth Hormone (GH) and Thyroid Stimulating Hormone (TSH) are examples of genes regulated by triiodothyronine (T3) in a positive and negative way, respectively. Recent studies have shown a rapid adjustment of GH and TSH synthesis/secretion induced by T3 posttranscriptional actions. In somatotrophs, T3 promotes an increase in Gh mRNA content, poly(A) tail length and binding to the ribosome, associated with a rearrangement of actin cytoskeleton...
September 26, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28948824/radioimmunoassay-of-chromogranin-a-and-free-metanephrines-in-diagnosis-of-pheochromocytoma
#19
R Bílek, T Zelinka, P Vlček, J Dušková, D Michalský, K Novák, E Václavíková, J Widimský
This work discusses the clinical performance of chromogranin A, free metanephrine and normetanephrine determination in plasma using a radioimmunoanalytical methods for the diagnosis of pheochromocytoma and paraganglioma. Blood samples were collected from 55 patients (46 pheochromocytomas, 9 paragangliomas). A sampling of biological materials was performed preoperatively and about one week, six months and one year after adrenal gland surgery. The comparative group without a diagnosis of pheochromocytoma/paraganglioma consisted of 36 pheochromocytoma/paraganglioma patients more than 4 months after adrenal gland surgery, and of 87 patients, 16 of them with multiple endocrine neoplasia, 9 with medullary and 5 with parafolicullar carcinoma of the thyroid gland...
September 26, 2017: Physiological Research
https://www.readbyqxmd.com/read/28948515/differential-molecular-targets-for-neuroprotective-effect-of-chlorogenic-acid-and-its-related-compounds-against-glutamate-induced-excitotoxicity-and-oxidative-stress-in-rat-cortical-neurons
#20
Olfa Rebai, Manel Belkhir, María Victoria Sanchez-Gomez, Carlos Matute, Sami Fattouch, Mohamed Amri
The present study has been designed to explore the molecular mechanism and signaling pathway targets of chlorogenic acid (CGA) and its main hydrolysates, caffeic (CA) and quinic acid in the protective effect against glutamate-excitotoxicity. For this purpose 8-DIV cortical neurons in primary culture were exposed to 50 μM L-glutamic acid plus 10 µM glycine, with or without 10-100 μM tested compounds. Chlorogenic acid and caffeic acid via their antioxidant properties inhibited cell death induced by glutamate in dose depended manner...
September 25, 2017: Neurochemical Research
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