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https://www.readbyqxmd.com/read/28194688/emergency-department-initiated-buprenorphine-for-opioid-dependence-with-continuation-in-primary-care-outcomes-during-and-after-intervention
#1
Gail D'Onofrio, Marek C Chawarski, Patrick G O'Connor, Michael V Pantalon, Susan H Busch, Patricia H Owens, Kathryn Hawk, Steven L Bernstein, David A Fiellin
BACKGROUND: Emergency department (ED)-initiated buprenorphine/naloxone with continuation in primary care was found to increase engagement in addiction treatment and reduce illicit opioid use at 30 days compared to referral only or a brief intervention with referral. OBJECTIVE: To evaluate the long-term outcomes at 2, 6 and 12 months following ED interventions. DESIGN: Evaluation of treatment engagement, drug use, and HIV risk among a cohort of patients from a randomized trial who completed at least one long-term follow-up assessment...
February 13, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28178893/sexually-transmitted-infection-prevalence-and-related-risk-factors-among-heterosexual-male-methamphetamine-users-in-china
#2
Dianchang Liu, Zhenxia Jiang, Cuizhen Xiu, Zhizhi Li, Qing Song, Zhenhong Wang
Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11.0. Among the 288 heterosexual male MA users, 51 (17.7%) had syphilis, 36 (12...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28135843/a-randomized-controlled-trial-of-ethyl-glucuronide-based-contingency-management-for-outpatients-with-co-occurring-alcohol-use-disorders-and-serious-mental-illness
#3
Michael G McDonell, Emily Leickly, Sterling McPherson, Jordan Skalisky, Debra Srebnik, Frank Angelo, Roger Vilardaga, Jenny R Nepom, John M Roll, Richard K Ries
OBJECTIVE: The authors examined whether a contingency management intervention using the ethyl glucuronide (EtG) alcohol biomarker resulted in increased alcohol abstinence in outpatients with co-occurring serious mental illnesses. Secondary objectives were to determine whether contingency management was associated with changes in heavy drinking, treatment attendance, drug use, cigarette smoking, psychiatric symptoms, and HIV-risk behavior. METHOD: Seventy-nine (37% female, 44% nonwhite) outpatients with serious mental illness and alcohol dependence receiving treatment as usual completed a 4-week observation period and were randomly assigned to 12 weeks of contingency management for EtG-negative urine samples and addiction treatment attendance, or reinforcement only for study participation...
January 31, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28126016/seroprevalence-of-toxoplasma-gondii-and-associated-risk-factors-among-hiv-infected-women-within-reproductive-age-group-at-mizan-aman-general-hospital-southwest-ethiopia-a-cross-sectional-study
#4
Ayalew Jejaw Zeleke, Yayehirad Alemu Melsew
BACKGROUND: Toxoplasmosis is serious in the case of immune suppression and prenatal transmission. In immunocompromised hosts, it is manifested primarily as a life-threatening condition, toxoplasmic encephalitis. Congenital toxoplasmosis results in abortion or congenitally acquired disorders which primarily affect the central nervous system. This study assessed seroprevalence of Toxoplasma gondii (T. gondii) infection and associated factors among HIV-infected women within the reproductive age group (18-49 years) at Mizan Aman General Hospital, Southwest Ethiopia...
January 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28117537/persistent-neuropsychiatric-impairment-in-hcv-patients-despite-clearance-of-the-virus
#5
M Dirks, H Pflugrad, K Haag, H L Tillmann, H Wedemeyer, D Arvanitis, H Hecker, A Tountopoulou, A Goldbecker, H Worthmann, K Weissenborn
One of the most disabling symptoms of hepatitis C virus (HCV) infection is chronic fatigue. While this is accepted for HCV polymerase chain reaction (PCR)-positive patients, a relationship between HCV infection and chronic fatigue is questioned after successful virus eradication. As fatigue is a subjective criterion, we aimed to evaluate in addition mood alterations and cognitive function in HCV-exposed patients with only mild liver disease and to assess a) possible interrelationships between these factors and health-related quality of life and b) the impact of viremia and former interferon treatment...
January 24, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28107824/implementation-of-methadone-therapy-for-opioid-use-disorder-in-russia-a-modeled-cost-effectiveness-analysis
#6
Bulat Idrisov, Sean M Murphy, Tyler Morrill, Mayada Saadoun, Karsten Lunze, Donald Shepard
BACKGROUND: Opioid agonist therapy using methadone, an effective treatment of opioid use disorders (OUD) for people who inject drugs (PWID), is recommended by the World Health Organization as essential to curtail the growing HIV epidemic. Yet, despite increasing prevalence of OUD and HIV, methadone therapy has not yet been implemented in Russia. The aim of this modeling study was to estimate the cost-effectiveness of methadone therapy for Russian adults with a diagnosed OUD. METHODS/DESIGN: We modeled the projected program implementation costs and estimated disability-adjusted life years (DALYs) averted over a 10-year period, associated with the provision of methadone therapy for a hypothetical, unreplenished cohort of Russian adults with an OUD (n = 249,000), in comparison to the current therapies at existing addiction treatment facilities...
January 20, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28026981/challenges-to-practicing-hiv-sex-risk-prevention-among-people-in-continuing-care-for-cocaine-addiction
#7
Alexandra S Wimberly, Max R Stern, Sarah B Rosenbach, Tyrone Thomas, James R McKay
BACKGROUND: Intimate partnerships are discouraged during early recovery, despite research that highlights their capacity to be resources for change. OBJECTIVE: This study seeks to provide descriptions of intimate partnerships and how such partnerships challenge and/or support minimizing HIV sex-risk among participants in continuing care for cocaine addiction in order to inform substance use programming. METHODS: Forty-two recorded continuing care counseling sessions of 33 people who discussed HIV sex-risk behavior were transcribed and analyzed using thematic analysis...
December 27, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/28018929/antiretroviral-therapy-as-prevention-of-%C3%A2-pneumococcal-infections
#8
Anaïs Lesourd, Jérémie Leporrier, Valérie Delbos, Guillemette Unal, Patricia Honoré, Manuel Etienne, Olivier Bouchaud, François Caron
BACKGROUND: Despite antiretroviral therapy, it is generally believed that the risk for pneumococcal infections (PnIs) is high among patients infected with human immunodeficiency virus (HIV). However, most studies in this field have been conducted before 2010, and the proportion of virologically suppressed patients has drastically increased in these latter years thanks to larger indications and more effective antiretroviral regimens. This study aimed to re-evaluate the current risk of PnI among adult patients infected with HIV...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27960229/automated-telephone-communication-systems-for-preventive-healthcare-and-management-of-long-term-conditions
#9
REVIEW
Pawel Posadzki, Nikolaos Mastellos, Rebecca Ryan, Laura H Gunn, Lambert M Felix, Yannis Pappas, Marie-Pierre Gagnon, Steven A Julious, Liming Xiang, Brian Oldenburg, Josip Car
BACKGROUND: Automated telephone communication systems (ATCS) can deliver voice messages and collect health-related information from patients using either their telephone's touch-tone keypad or voice recognition software. ATCS can supplement or replace telephone contact between health professionals and patients. There are four different types of ATCS: unidirectional (one-way, non-interactive voice communication), interactive voice response (IVR) systems, ATCS with additional functions such as access to an expert to request advice (ATCS Plus) and multimodal ATCS, where the calls are delivered as part of a multicomponent intervention...
14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27955689/the-effect-of-bundling-medication-assisted-treatment-for-opioid-addiction-with-mhealth-study-protocol-for-a-randomized-clinical-trial
#10
David H Gustafson, Gina Landucci, Fiona McTavish, Rachel Kornfield, Roberta A Johnson, Marie-Louise Mares, Ryan P Westergaard, Andrew Quanbeck, Esra Alagoz, Klaren Pe-Romashko, Chantelle Thomas, Dhavan Shah
BACKGROUND: Opioid dependence has devastating and increasingly widespread consequences and costs, and the most common outcome of treatment is early relapse. People who inject opioids are also at disproportionate risk for contracting the human immunodeficiency virus (HIV) and hepatitis C virus (HCV). This study tests an approach that has been shown to improve recovery rates: medication along with other supportive services (medication-assisted treatment, or MAT) against MAT combined with a smartphone innovation called A-CHESS (MAT + A-CHESS)...
December 12, 2016: Trials
https://www.readbyqxmd.com/read/27921633/healthcare-resources-are-inadequate-to-address-the-burden-of-illness-among-hiv-infected-male-prisoners-in-malaysia
#11
Joseph Bick, Gabriel Culbert, Haider A Al-Darraji, Clayton Koh, Veena Pillai, Adeeba Kamarulzaman, Frederick Altice
Purpose Criminalization of drug use in Malaysia has concentrated people who inject drugs (PWID) and people living with HIV into prisons where health services are minimal and HIV-related mortality is high. Few studies have comprehensively assessed the complex health needs of this population. The paper aims to discuss these issues. Design/methodology/approach From October 2012 through March 2013, 221 sequentially selected HIV-infected male prisoners underwent a comprehensive health assessment that included a structured history, physical examination, and clinically indicated diagnostic studies...
December 19, 2016: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/27907848/fatal-and-non-fatal-overdose-after-narcology-hospital-discharge-among-russians-living-with-hiv-aids-who-inject-drugs
#12
Alexander Y Walley, Debbie M Cheng, Emily K Quinn, Elena Blokhina, Natalia Gnatienko, Christine E Chaisson, Evgeny Krupitsky, Philip O Coffin, Jeffrey H Samet
OBJECTIVES: Among Russians living with HIV/AIDS who inject drugs, we examined the incidence of fatal and non-fatal overdoses following discharge from a narcology hospital and the associations with more advanced HIV infection. DESIGN: Prospective cohort study of data collected at baseline, 3 and 6 months from HIV-infected patients with a history of injection drug use who were not treated with anti-retroviral therapy. Participants were recruited between 2012-2014 from a narcology (addiction) hospital in St...
January 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27898683/mortality-in-hiv-infected-alcohol-and-drug-users-in-st-petersburg-russia
#13
Nadia S Fairbairn, Alexander Y Walley, Debbie M Cheng, Emily Quinn, Carly Bridden, Christine Chaisson, Elena Blokhina, Dmitry Lioznov, Evgeny Krupitsky, Anita Raj, Jeffrey H Samet
In Russia, up to half of premature deaths are attributed to hazardous drinking. The respective roles of alcohol and drug use in premature death among people with HIV in Russia have not been described. Criminalization and stigmatization of substance use in Russia may also contribute to mortality. We explored whether alcohol, drug use and risk environment factors are associated with short-term mortality in HIV-infected Russians who use substances. Secondary analyses were conducted using prospective data collected at baseline, 6 and 12-months from HIV-infected people who use substances recruited between 2007-2010 from addiction and HIV care settings in a single urban setting of St...
2016: PloS One
https://www.readbyqxmd.com/read/27876616/the-starting-treatment-for-ethanol-in-primary-care-trials-step-trials-protocol-for-three-parallel-multi-site-stepped-care-effectiveness-studies-for-unhealthy-alcohol-use-in-hiv-positive-patients
#14
E Jennifer Edelman, Stephen A Maisto, Nathan B Hansen, Christopher J Cutter, James Dziura, Lynn E Fiellin, Patrick G O'Connor, Roger Bedimo, Cynthia Gibert, Vincent C Marconi, David Rimland, Maria C Rodriguez-Barradas, Michael S Simberkoff, Amy C Justice, Kendall J Bryant, David A Fiellin
Unhealthy alcohol use is common among HIV-positive patients, yet effective evidence-based treatments are rarely provided in clinical settings providing HIV care. Further, given patient variability in response to initial treatments, stepped care approaches may be beneficial. We describe the rationale, aims and study design for the current StartingTreatment forEthanol inPrimary care Trials (STEP Trials); three parallel randomized controlled effectiveness trials being conducted in five Infectious Disease Clinics...
January 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27876048/an-integrated-approach-to-care-attracts-people-living-with-hiv-who-use-illicit-drugs-in-an-urban-centre-with-a-concentrated-hiv-epidemic
#15
S Fernando, R McNeil, K Closson, H Samji, S Kirkland, C Strike, R Baltzer Turje, W Zhang, R S Hogg, S Parashar
BACKGROUND: People living with HIV (PLHIV) who are also marginalized by social and structural inequities often face barriers to accessing and adhering to HIV treatment and care. The Dr. Peter Centre (DPC) is a non-profit integrated care facility with a supervised injection room that serves PLHIV experiencing multiple barriers to social and health services in Vancouver, Canada. This study examines whether the DPC is successful in drawing in PLHIV with complex health issues, including addiction...
November 22, 2016: Harm Reduction Journal
https://www.readbyqxmd.com/read/27871198/-it-is-easier-for-me-to-shoot-up-stigma-abandonment-and-why-hiv-positive-drug-users-in-russia-fail-to-link-to-hiv-care
#16
Tetiana Kiriazova, Karsten Lunze, Anita Raj, Natalia Bushara, Elena Blokhina, Evgeny Krupitsky, Carly Bridden, Dmitry Lioznov, Jeffrey H Samet, Allen L Gifford
Many HIV-positive people who inject drugs (PWID) globally are not receiving HIV care. This represents a major challenge among key populations to end the global HIV epidemic. This qualitative study explored the process and associated barriers of linking HIV-positive PWID who are in addiction treatment to HIV care in St. Petersburg, Russia. We conducted three focus groups and seven semi-structured interviews with participants in the LINC ("Linking Infectious and Narcology Care") project at addiction and HIV hospitals in St...
November 22, 2016: AIDS Care
https://www.readbyqxmd.com/read/27820957/survival-and-predictors-of-mortality-among-human-immunodeficiency-virus-patients-on-anti-retroviral-treatment-at-jinka-hospital-south-omo-ethiopia-a-six-years-retrospective-cohort-study
#17
Erdaw Tachbele, Gobena Ameni
OBJECTIVES: The survival rate of human immunodeficiency virus (HIV)-infected patients receiving treatment in Ethiopia is poorly understood. This study aimed to determine the survival rate and predictors of mortality among HIV-infected adults on antiretroviral therapy (ART) at Jinka Hospital, South Omo, Ethiopia. METHODS: A 6-year retrospective cohort study was conducted using 350 patient records drawn from 1,899 patients on ART at Jinka Hospital from September 2010 to August 2015...
2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27717364/meaningful-engagement-of-people-living-with-hiv-who-use-drugs-methodology-for-the-design-of-a-peer-research-associate-pra-hiring-model
#18
K Closson, R McNeil, P McDougall, S Fernando, A B Collins, R Baltzer Turje, T Howard, S Parashar
BACKGROUND: Community-based HIV, harm reduction, and addiction research increasingly involve members of affected communities as Peer Research Associates (PRAs)-individuals with common experiences to the participant population (e.g. people who use drugs, people living with HIV [PLHIV]). However, there is a paucity of literature detailing the operationalization of PRA hiring and thus limited understanding regarding how affected communities can be meaningfully involved through low-barrier engagement in paid positions within community-based participatory research (CBPR) projects...
October 7, 2016: Harm Reduction Journal
https://www.readbyqxmd.com/read/27715904/recent-incarceration-and-buprenorphine-maintenance-treatment-outcomes-among-human-immunodeficiency-virus-positive-patients
#19
Daniel P Riggins, Chinazo O Cunningham, Yuming Ning, Aaron D Fox
BACKGROUND: Opioid use disorder is a common cause of morbidity and mortality among people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Buprenorphine maintenance treatment (BMT) is an effective means of therapy, but patients with recent criminal justice involvement may need more support during BMT than other patients. The authors hypothesized that recently incarcerated BMT patients who initiated treatment in primary care would have poorer treatment outcomes than those who were not recently incarcerated...
August 11, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27668463/modeling-the-effects-of-morphine-on-simian-immunodeficiency-virus-dynamics
#20
Naveen K Vaidya, Ruy M Ribeiro, Alan S Perelson, Anil Kumar
Complications of HIV-1 infection in individuals who utilize drugs of abuse is a significant problem, because these drugs have been associated with higher virus replication and accelerated disease progression as well as severe neuropathogenesis. To gain further insight it is important to quantify the effects of drugs of abuse on HIV-1 infection dynamics. Here, we develop a mathematical model that incorporates experimentally observed effects of morphine on inducing HIV-1 co-receptor expression. For comparison we also considered viral dynamic models with cytolytic or noncytolytic effector cell responses...
September 2016: PLoS Computational Biology
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