keyword
MENU ▼
Read by QxMD icon Read
search

sab

keyword
https://www.readbyqxmd.com/read/29165572/principled-approaches-to-missing-data-in-epidemiologic-studies
#1
Neil J Perkins, Stephen R Cole, Ofer Harel, Eric J Tchetgen Tchetgen, BaoLuo Sun, Emily M Mitchell, Enrique F Schisterman
Principled methods to appropriately analyze missing data have long existed; however, broad implementation of these methods remains challenging. In this and companion papers, we discuss issues of missing data in the epidemiologic literature. We provide details regarding missing data mechanisms and nomenclature and motivate principled analyses through a detailed comparison of multiple imputation and inverse probability weighting. We do so in the setting of a masked data-analytic challenge with missing data induced by known mechanisms to data from the Collaborative Perinatal Project, a multisite US study conducted from 1959 to 1974...
November 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29165557/inverse-probability-weighted-estimation-for-monotone-and-nonmonotone-missing-data
#2
BaoLuo Sun, Neil J Perkins, Stephen R Cole, Ofer Harel, Emily Mitchell, Enrique F Schisterman, Eric J Tchetgen Tchetgen
Missing data is of common occurrence in epidemiologic research. In this paper, three data sets with induced missing values from the Collaborative Perinatal Project, a multisite United States study conducted from 1959 to 1974, are provided as examples of prototypical epidemiologic studies with missing data. Our goal is to estimate the effect of maternal smoking behavior on spontaneous abortion while adjusting for numerous confounders. At the same time, we do not necessarily wish to evaluate the joint distribution among potentially unobserved covariates, which is seldom the subject of substantive scientific interest...
November 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29165547/multiple-imputation-for-incomplete-data-in-epidemiologic-studies
#3
Ofer Harel, Emily M Mitchell, Neil J Perkins, Stephen R Cole, Eric J Tchetgen Tchetgen, BaoLuo Sun, Enrique F Schisterman
Epidemiologic studies are frequently susceptible to missing information. Omitting observations with missing variables remains a common strategy in epidemiologic studies, yet this simple approach can often severely bias parameter estimates of interest if the values are not missing completely at random. Even when missingness is completely random, complete case analysis can reduce efficiency of estimated parameters, because large amounts of available data are simply tossed out with the incomplete observations...
November 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29163762/bmal1-facilitates-trophoblast-migration-and-invasion-via-sp1-dnmt1-dab2ip-pathway-in-recurrent-spontaneous-abortion
#4
Shang Li, Junyu Zhai, Jiansheng Liu, Yan Hong, Weixiu Zhao, Aimin Zhao, Kang Sun, Yanzhi Du, Zi-Jiang Chen
The underlying mechanism about rhythms and epigenetics leading to aberrant trophoblast migration and invasion in recurrent spontaneous abortion (RSA) remains unknown. Brain and muscle ARNT-like protein 1 (BMAL1) is considered as a crucial role in fertility, and polymorphism of BMAL1 gene has been reported to be associated with risk of miscarriage. However, the functional role of BMAL1 in RSA is not fully understood. Previous study shows the descended expression of DNA 5'-cytosine-methyltransferases 1 (DNMT1) in the villous of early pregnancy loss...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163462/impact-of-preformed-donor-specific-anti-human-leukocyte-antigen-antibody-c1q-binding-ability-on-kidney-allograft-outcome
#5
Juan Molina, Ana Navas, María-Luisa Agüera, Cristian Rodelo-Haad, Corona Alonso, Alberto Rodríguez-Benot, Pedro Aljama, Rafael Solana
The consolidation of single antigen beads (SAB-panIgG) assay in the detection of preformed anti-human leukocyte antigen (HLA) antibodies has improved transplantation success. However, its high sensitivity has limited the allograft allocation for sensitized patients, increasing their waiting time. A modification of the standard SAB-panIgG assay allows the detection of that subset of antibodies capable of binding C1q (SAB-C1q assay). However, the clinical usefulness of SAB-C1q assay for determining the unacceptable mismatches is under discussion...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29161942/trends-in-incidence-and-resistance-patterns-of-staphylococcus-aureus-bacteremia
#6
Elina Jokinen, Janne Laine, Reetta Huttunen, Outi Lyytikäinen, Risto Vuento, Jaana Vuopio, Jaana Syrjänen
BACKGROUND: Staphylococcus aureus bacteremia (SAB) causes a significant burden on the population. Several infection control measures have been implemented in Pirkanmaa county to combat a local epidemic with methicillin-resistant Staphylococcus aureus (MRSA). We aimed to study the epidemiology of SAB and antibiotic resistance of S. aureus and the possible influence of improved infection control. METHODS: Register data from 2005 to 2015 were retrospectively analysed to study the antimicrobial susceptibility, the incidence and mortality in SAB in a population-based setting...
November 21, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29161941/are-we-missing-the-staphylococcus-aureus-bacteraemia-forest-for-the-mrsa-trees
#7
Kevin B Laupland
In this edition of the journal, Jokinen et al. report on a population based study of Staphylococcus aureus bacteraemia (SAB) in Finland. They observe increasing incidence of cases over time that are associated with an increase in blood culture sampling. As compared to methicillin-sensitive SAB that increases during the study period, the incidence of methicillin-resistant SAB increases and then decreases. The proportion of cases with penicillin-sensitive SAB markedly increases in the study representing 43% of isolates in the most recent year of surveillance...
November 21, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29158370/ovarian-and-uterine-functions-in-female-survivors-of-childhood-cancers
#8
REVIEW
Ozgur Oktem, Samuel S Kim, Ugur Selek, Glenn Schatmann, Bulent Urman
Adult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29154462/the-role-of-indoleamine-2-3-dioxygenase-in-normal-and-pathological-pregnancies
#9
REVIEW
Rui-Qi Chang, Da-Jin Li, Ming-Qing Li
The survival of allogeneic fetus during pregnancy contradicts the laws of immune responses. Behind this paradoxical phenomenon, the mechanism is quite complex. Indoleamine-2,3-dioxygenase (IDO) is the first and rate-limiting enzyme of tryptophan catabolism. Emerging evidence shows that IDO is expressed at the maternal-fetal interface, including trophoblast cells, decidual stroma cells, decidual immune cells (eg, natural killer cells, T cells, and macrophages), and vascular endothelial cells of decidua and chorion...
November 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29153470/impact-of-a-pharmacist-driven-care-package-on-staphylococcus-aureus-bacteremia-management-in-a-large-community-healthcare-network-a-propensity-score-matched-quasi-experimental-study
#10
Jordan R Smith, Jeremy J Frens, Cynthia B Snider, Kimberly C Claeys
OBJECTIVES: Staphylococcus aureus bacteremia (SAB) is an important cause of morbidity and mortality. Suboptimal treatment has been associated with poor patient outcomes. Our antimicrobial stewardship program (ASP) evaluated SAB management based on predefined performance measures both prior to and after instituting a "care package" intervention led by clinical pharmacists and infectious diseases physicians. The primary outcome included a 4-point "optimal care score" (OCS) consisting of targeted antibiotic therapy within 24hours, repeating blood cultures, antibiotic duration assessment, and appropriate duration of therapy...
October 7, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29150062/spontaneous-abortion-and-ectopic-pregnancy-case-definition-guidelines-for-data-collection-analysis-and-presentation-of-maternal-immunization-safety-data
#11
Caroline E Rouse, Linda O Eckert, Isaac Babarinsa, Emily Fay, Manish Gupta, Margo S Harrison, Alison Tse Kawai, Elyse O Kharbanda, Merita Kucuku, Lee Meller, Tamala Mallett Moore, Maja Subelj, Sonali Kochhar, Fernanda Tavares-Da-Silva
No abstract text is available yet for this article.
December 4, 2017: Vaccine
https://www.readbyqxmd.com/read/29149956/comparison-between-total-igg-c1q-and-c3d-single-antigen-bead-assays-in-detecting-class-i-complement-binding-anti-hla-antibodies
#12
M A Moreno Gonzales, D G Mitema, B H Smith, C A Schinstock, M D Stegall, L L Wakefield, N A Henderson, S R DeGoey, J D Kreuter, M J Gandhi
BACKGROUND: Complement-binding donor-specific antibodies (DSAs) are associated with antibody-mediated rejection and allograft loss. Novel single antigen bead (SAB) assays-that is, complement component 1q (C1q) and complement component 3d (C3d) assays-have been developed to specifically detect complement-binding DSA, but it remains unclear whether these assays have an improved ability to detect complement-binding DSA as compared with using the total IgG SAB assay with a high mean fluorescence intensity (MFI) cutoff...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149524/a-systematic-review-and-meta-analysis-of-fetal-outcomes-following-the-administration-of-influenza-a-h1n1-vaccination-during-pregnancy
#13
REVIEW
Chuan Zhang, Xiaodong Wang, Dan Liu, Lingli Zhang, Xin Sun
BACKGROUND: Pregnant women were identified as a population of priority for vaccination during the H1N1 influenza pandemic breaking out in 2009. OBJECTIVES: To assess adverse fetal outcomes following the administration of H1N1 pandemic vaccination during pregnancy. SEARCH STRATEGY: PubMed, Embase, and Cochrane Library were searched up to January 2017. SELECTION CRITERIA: Cohort studies investigating fetal outcomes after H1N1 influenza vaccination during pregnancy were eligible...
November 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29146429/routine-screening-for-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-first-trimester-abortion
#14
Ryan Schlueter, Andrea Siu, James Shelton, Men-Jean Lee
Currently no recommendation exists to collect genital culture for Chlamydia trachomatis and Neisseria gonorrhoeae at diagnosis of spontaneous abortion. A retrospective cross sectional study was performed to identify first trimester abortions with concurrent genital culture collection in an emergency room setting. The results were compared to most current 2015 Center for Disease Control (CDC) statistics. Among women aged 15-24 the rate of C. trachomatis was increased to 20.0% and greater than CDC rate of 6.7% (RR 2...
November 13, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29145465/hospital-associated-methicillin-resistant-staphylococcus-aureus-a-cross-sectional-analysis-of-risk-factors-in-south-african-tertiary-public-hospitals
#15
Liliwe L Shuping, Lazarus Kuonza, Alfred Musekiwa, Samantha Iyaloo, Olga Perovic
INTRODUCTION: Hospital-associated methicillin-resistant S. aureus (HA-MRSA) remains a significant cause of morbidity and mortality worldwide. We conducted a study to determine risk factors for HA-MRSA in order to inform control strategies in South Africa. METHODS: We used surveillance data collected from five tertiary hospitals in Gauteng and Western Cape provinces during 2014 for analysis. A case of HA-MRSA was defined as isolation of MRSA from a blood culture 48 hours after admission and/or if the patient was hospitalised in the six months prior to the current culture...
2017: PloS One
https://www.readbyqxmd.com/read/29130666/-application-of-chromosomal-microarray-analysis-for-chromosomal-abnormalities-of-spontaneously-aborted-fetuses
#16
Ting Hu, Hong-Mei Zhu, Zhu Zhang, Jia-Min Wang, Hai-Xia Zhang, Ze Du, Ling-Pingi Li, He Wang, Shan-Ling Liu
OBJECTIVE: To evaluate the clinical significance of chromosomal microarry analysis (CMA) for detection of chromosomal abnormalities in spontaneously aborted fetuses. METHODS: Chorionic villi samples from 431 spontaneously aborted fetuses were detected on the chromosomal abnormalities by CMA in our department form September 2014 to April 2016. RESULTS: The overall success rate of CMA was 100%,and 283 cases were detected with abnormalities (65...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29122896/persistent-bacteraemia-caused-by-staphylococcus-aureus-in-the-gall-bladder
#17
Alexander Tin Han Yu, Tony Cun, Esther Benamu, Cybele Renault
Staphylococcus aureusbacteraemia (SAB) remains a complex disease with a high associated morbidity and mortality, especially when it is able to establish an occult nidus safe from antimicrobial eradication. Without rapid identification and intervention, the nidus can cause persistent relapse of disease, morbidity and mortality. Having a high clinical suspicion for the foci of occult S. aureus is important, and awareness of potential sites of infection is critical and can be life-saving.We present a unique case of a 65-year-old man with end-stage renal disease receiving haemodialysis who developed septic shock from SAB...
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29117563/outcomes-of-congenital-zika-disease-depend-on-timing-of-infection-and-maternal-fetal-interferon-action
#18
Jinling Chen, Yuejin Liang, Panpan Yi, Lanman Xu, Hal K Hawkins, Shannan L Rossi, Lynn Soong, Jiyang Cai, Ramkumar Menon, Jiaren Sun
Zika virus (ZIKV) infection during pregnancy in humans results in intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we found that fetus-derived type I interferon (IFN-I) signaling can enhance anti-ZIKV responses and provide clinical benefits to the fetus. Because IFN-λ shares signaling cascades and antiviral functions with IFN-I, we investigated the in vivo effects of IFN-λ in ZIKV-infected pregnant mice. IFN-λ administration during mid-pregnancy reduced ZIKV burden in maternal and fetal organs and alleviated placental injuries and fetal demise...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29115883/pharmacotherapeutic-options-for-treating-staphylococcus-aureus-bacteremia
#19
Carlota Gudiol, Guillermo Cuervo, Evelyn Shaw, Miquel Pujol, Jordi Carratalà
Case-fatality rates for Staphylococcus aureus bacteremia (SAB) remain unacceptably high and have improved only modestly in recent decades. Treatment of SAB is still a clinical challenge, especially if methicillin-resistant strains are involved. New drugs with anti-staphylococcal activity are currently available, and their role as alternatives to standard therapies is being investigated. Areas covered: In this review, we give an update of the current available antibiotics for the treatment of SAB. We provide information regarding the pharmacological characteristics, the accepted indications, and the most important adverse events of the old and new anti- staphylococcal agents, as well as the existing evidence on their use for the treatment of SAB...
November 8, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29113531/detection-of-cytomegalovirus-herpes-virus-simplex-and-parvovirus-b19-in-spontaneous-abortion-placentas
#20
Gabriela Mafra de Oliveira, Marcelo Antônio Pascoal-Xavier, Daniel R Moreira, Vitor Souza Guimarães, Regina Amélia Lopes Pessoa de Aguiar, Débora Marques de Miranda, Roberta Maia de Castro Romanelli
OBJECTIVE: This study aims to investigate the presence of Cytomegalovirus (CMV), herpes virus simplex (HSV), and parvovirus B19 (PVB19) in the placental tissue of patients who underwent abortions without an otherwise-defined aetiology. STUDY DESIGN: This cross-sectional study was conducted in a high-risk obstetric maternity facility at a University Hospital in Belo Horizonte, Brazil, from January 2013 to December 2015. We included placenta samples obtained from spontaneous abortions of unknown aetiology...
November 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
keyword
keyword
46430
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"