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https://www.readbyqxmd.com/read/28213897/laryngo-onycho-cutaneous-like-syndrome-due-to-mutated-plectin
#1
Christine Prodinger, Alfred Klausegger, Anja Diem, Johann W Bauer, Martin Laimer
Laryngo-onycho-cutaneous syndrome (LOC) is a rare autosomal recessive genodermatosis that has been mainly described in the offspring of consanguineous families with origin in the Punjabi region of Pakistan and India [1]. Founder mutations affecting the LAMA3A gene on chromosome 18q11.2 have been implicated to underlie this syndrome [1,2]. Based on its molecular and clinical features, LOC was recently classified as a subtype of junctional Epidermolysis bullosa (JEB) [1]. This article is protected by copyright...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28211993/recent-lab-on-chip-developments-for-novel-drug-discovery
#2
REVIEW
Nauman Khalid, Isao Kobayashi, Mitsutoshi Nakajima
Microelectromechanical systems (MEMS) and micro total analysis systems (μTAS) revolutionized the biochemical and electronic industries, and this miniaturization process became a key driver for many markets. Now, it is a driving force for innovations in life sciences, diagnostics, analytical sciences, and chemistry, which are called 'lab-on-a-chip, (LOC)' devices. The use of these devices allows the development of fast, portable, and easy-to-use systems with a high level of functional integration for applications such as point-of-care diagnostics, forensics, the analysis of biomolecules, environmental or food analysis, and drug development...
February 17, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28209532/stability-of-problematic-eating-behaviors-and-weight-loss-trajectories-after-bariatric-surgery-a-longitudinal-observational-study
#3
Eva M Conceição, James E Mitchell, Ana Pinto-Bastos, Filipa Arrojado, Isabel Brandão, Paulo P P Machado
BACKGROUND: The literature is rather mixed regarding the stability and the role of pre- and postoperative problematic eating behaviors (PEBs) on weight outcomes after bariatric surgery. OBJECTIVES: To investigate the stability of loss of control (LOC) eating and picking and/or nibbling from pre- to postoperative assessments, and to investigate whether pre- and postoperative PEBs are predictors of different weight loss trajectories. SETTING: Central Hospital, University, Portugal...
December 20, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28205485/asymptomatic-flexor-tendon-damages-after-volar-locking-plate-fixation-of-distal-radius-fractures
#4
Susumu Tokunaga, Yoshihiro Abe
BACKGROUND: To investigate asymptomatic flexor tendon damages after volar locking plate fixation of distal radius fractures in 32 wrists of 32 patients with distal radius fractures fixed using two plate types. Sixteen patients received the Acu-Loc volar distal radius plate, and the remaining 16 patients received the Aptus distal radius correction plate. METHODS: The flexor pollicis longus (FPL) tendon and flexor digitorum profundus were evaluated according to intraoperative findings at plate removal...
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28205275/psychometric-evaluation-of-the-youth-eating-disorder-examination-questionnaire-in-children-with-overweight-or-obesity
#5
Andrea E Kass, Kelly Theim Hurst, Rachel P Kolko, Elizabeth B Ruzicka, Richard I Stein, Brian E Saelens, R Robinson Welch, Michael G Perri, Kenneth B Schechtman, Leonard H Epstein, Denise E Wilfley
This study evaluated the psychometric properties of the Youth Eating Disorder Examination Questionnaire (YEDE-Q) and its utility for detecting loss of control (LOC) eating (i.e., eating episodes, regardless of size, involving a perceived inability to control what or how much one is eating) among school-age children with overweight or obesity. Identifying eating pathology, particularly LOC eating, in this population may facilitate treatment that improves weight outcomes and reduces eating disorder risk. Children with overweight or obesity (N = 241; 7-11 years) completed the YEDE-Q and abbreviated Child EDE (ChEDE) to assess LOC eating, prior to entering a weight management treatment trial...
February 15, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28203641/the-antecedents-of-women-s-external-locus-of-control-associations-with-characteristics-of-their-parents-and-their-early-childhood
#6
Jean Golding, Steven Gregory, Yasmin Iles-Caven, Stephen Nowicki
Locus of control (LOC) measures individuals' expectancies regarding their ability to affect what happens to them based on how they behave. The more they believe their behaviour has something to do with what happens to them the more internal they are. In contrast the more they perceive that what happens to them is beyond their control and determined by luck, fate, chance or powerful others the more external they are. Copious research findings suggest that external LOC (ELOC) is associated with many adverse personal, social, academic and health outcomes...
January 2017: Heliyon
https://www.readbyqxmd.com/read/28195460/correction-to-raman-characterization-of-the-charge-density-wave-phase-of-1t-tise2-from-bulk-to-atomically-thin-layers
#7
Dinh Loc Duong, Gihun Ryu, Alexander Hoyer, Chengtian Lin, Marko Burghard, Klaus Kern
No abstract text is available yet for this article.
February 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28195340/preventive-benefit-of-access-to-fluoridated-water-for-young-adults
#8
A John Spencer, Pingzhou Liu, Jason Mathew Armfield, Loc Giang Do
: Water fluoridation has been repeatedly associated with lower caries experience in children but uncertainty still exists on strength and extent of the association into adulthood. OBJECTIVE: To analyze the preventive effect of access to fluoridated water on dental caries among young adults. METHODS: In 1991/92 a cross-section of South Australian children aged 5-17 were recruited. Parents provided information on residential history, socioeconomic status, and behaviors...
February 13, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28192585/correlations-of-objective-metrics-for-quantifying-dysfunctional-lens-syndrome-with-visual-acuity-and-phacodynamics
#9
Fernando Faria-Correia, Isaac Ramos, Bernardo Lopes, Tiago Monteiro, Nuno Franqueira, Renato Ambrósio
PURPOSE: To study the relationship between objective metrics for quantifying crystalline lens dysfunction with visual impairment and phacodynamics parameters in age-related nuclear cataracts. METHODS: A total of 51 eyes (34 patients) with age-related nuclear cataract had phacoemulsification. The Dysfunctional Lens Index (0 to 10 points) was measured by a ray-tracing aberrometry (iTrace Visual Function Analyzer; Tracey Technologies, Houston, TX). The average lens density (0 to 100) was evaluated using a rotating Scheimpflug system (Pentacam HR; Oculus Optikgeräte GmbH, Wetzlar, Germany), and the nuclear opalescence score was subjectively assessed using the Lens Opacities Classification System III (LOCS III)...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28185892/lack-of-patient-clinician-concordance-in-cancer-patients-its-relation-with-patient-variables
#10
Kavita D Chandwani, Fengmin Zhao, Gary R Morrow, Teresa L Deshields, Lori M Minasian, Judith Manola, Michael J Fisch
CONTEXT: Patients with cancer are bothered by its diagnosis, treatment, and associated uncertainty. Lack of concordance (LOC) of patients' reporting of their symptoms and quality of life (QOL) with that of their clinicians has been observed in cancer care. However, information regarding the reporting of patients' bother due to aspects of cancer experience and their clinicians' assessment is lacking. OBJECTIVES: To describe cancer patients' bother due to aspects of their disease experience and explore the concordance (LOC) or a lack thereof between patients' and clinicians' reporting of patients' bother and factors associated with it...
February 6, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28182590/lens-opacity-and-hydrogen-sulfide-in-a-new-zealand-geothermal-area
#11
Michael N Bates, Ian L Bailey, Robert B DiMartino, Karl Pope, Julian Crane, Nick Garrett
PURPOSE: Hydrogen sulfide (H2S) is a highly toxic gas with well-established, acute irritation effects on the eye. The population of Rotorua, New Zealand, sited on an active geothermal field, has some of the highest ambient H2S exposures in the world. Evidence from ecological studies in Rotorua has suggested that H2S is associated with cataract. The purpose of the present study was, using more detailed exposure characterization, clinical examinations, and anterior eye photography, to more directly investigate this previously reported association...
January 11, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28179199/robotic-cystotomy-for-pessary-extraction-with-vesicovaginal-fistula-repair
#12
Whitney Goldsberry, Daniel S Metzinger
STUDY OBJECTIVE: To demonstrate a robotic approach to foreign body extraction and vesicovaginal fistula repair. DESIGN: Video case presentation with narration discussing the step-by-step robotic surgical approach to the removal of a pessary, via cystotomy, followed by vesicovaginal fistula and cystotomy repair. SETTING: University of Louisville Hospital. The local Institutional Review Board deemed the video exempt from formal approval. PATIENT: A 77-year-old woman presented with complaints of vaginal leakage of urine, dysuria, and pelvic pain...
February 4, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28177831/rapid-identification-of-a-new-gene-influencing-low-amylose-content-in-rice-landraces-oryza-sativa-l-using-genome-wide-association-study-with-specific-locus-amplified-fragment-sequencing
#13
Xinghai Yang, Baoxuan Nong, Xiuzhong Xia, Zongqiong Zhang, Yu Zeng, Kaiqiang Liu, Guofu Deng, Danting Li
Starch is the major compoments of milled rice, and amylose content (AC) affects eating quality. In this study, genome-wide association study (GWAS) with specific-locus amplified fragment sequencing (SLAF-seq) data was performed for AC in a panel of 419 core collection for rice landraces. Using the compressed mixed linear method based on the Q+K model, we identified a new gene LAC6 (Chr6: 5.65 Mb ~ 6.04 Mb) associated with AC in the low amylose content panel. The candidate genes of LAC6 was detected through qRT-PCR in rice panicles...
December 23, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28175997/nothing-left-to-chance-the-impact-of-locus-of-control-on-physical-and-mental-quality-of-life-in-terminal-cancer-patients
#14
Alaina J Brown, Premal H Thaker, Charlotte C Sun, Diana L Urbauer, Eduardo Bruera, Diane C Bodurka, Lois M Ramondetta
PURPOSE: The purpose of this study is to evaluate if locus of control (LOC) predicts various quality of life (QOL) and mental well-being measures among terminally ill cancer patients at the time of palliative care consult. METHODS: Multi-site analysis of patients with advanced cancer being seen as new patients in a Palliative and Supportive Care outpatient clinic. Patients completed the following surveys: locus of control (LOC) scale, Functional Assessment of Chronic Illness Therapy-General (FACT-G), Functional Assessment of Chronic Illness Therapy-Spiritual (FACIT-Sp), Hospital Anxiety Depression Scale (HADS), and Herth Hope Index (HHI)...
February 7, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28174825/diet-induced-overweight-and-obesity-and-periodontitis-risk-an-application-of-the-parametric-g-formula-in-the-1982-pelotas-birth-cohort
#15
Gustavo G Nascimento, Marco A Peres, Murthy N Mittinty, Karen G Peres, Loc G Do, Bernardo L Horta, Denise P Gigante, Marcos B Corrêa, Flávio F Demarco
No abstract text is available yet for this article.
February 8, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28174587/integrating-small-rna-sequencing-with-qtl-mapping-for-identification-of-mirnas-and-their-target-genes-associated-with-heat-tolerance-at-the-flowering-stage-in-rice
#16
Qing Liu, Tifeng Yang, Ting Yu, Shaohong Zhang, Xingxue Mao, Junliang Zhao, Xiaofei Wang, Jingfang Dong, Bin Liu
Although, microRNAs (miRNAs) have been reported to be associated with heat tolerance at the seedling stage in rice, their involvement in heat tolerance at the flowering stage is still unknown. In this study, small RNA profiling was conducted in a heat-tolerant variety Gan-Xiang-Nuo (GXN) and a heat-sensitive variety Hua-Jing-Xian-74 (HJX), respectively. Totally, 102 miRNAs were differentially expressed (DE) under heat stress. Compared to HJX, GXN had more DE miRNAs and its DE miRNAs changed earlier under heat stress...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28170122/utility-of-serum-biomarkers-in-the-diagnosis-and-stratification-of-mild-traumatic-brain-injury
#17
Lawrence M Lewis, Derek Schloemann, Linda Papa, Robert Fucetola, Jeffrey Bazarian, Miranda Lindburg, Robert Welch
OBJECTIVE: To compare test characteristics of a single serum concentration of glial fibrillary acidic protein (GFAP), S-100β, and ubiquitin carboxyl terminal hydrolase L1 (UCH-L1), obtained within 6 hours of head injury, to diagnose mild traumatic brain injury (mTBI) in head-injured subjects. METHODS: Adults aged 18-80 who presented to one of seven EDs with a blunt closed head injury, underwent head CT within 4 hours of injury, and had blood drawn for biomarker analysis within 6 hours of injury were eligible...
February 7, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28169921/predicting-the-magnitude-of-functional-and-structural-damage-in-glaucoma-from-monocular-pupillary-light-responses-using-automated-pupillography
#18
Zia S Pradhan, Harsha L Rao, Narendra K Puttaiah, Sujatha V Kadambi, Srilakshmi Dasari, Hemanth B Reddy, Meena Palakurthy, Mohammed Riyazuddin, Dhanaraj A S Rao
PURPOSE: To predict the magnitude of functional damage [mean deviation (MD) on visual field examination] and structural damage [retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness on spectral domain optical coherence tomography] in glaucoma from monocular pupillary light response measurements using automated pupillography. METHODS: In total, 59 subjects (118 eyes) with either a confirmed or suspected diagnosis of glaucoma underwent automated pupillography, along with visual fields and spectral domain optical coherence tomography examinations...
February 6, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28167769/multifunctional-inexpensive-and-reusable-nanoparticle-printed-biochip-for-cell-manipulation-and-diagnosis
#19
Rahim Esfandyarpour, Matthew J DiDonato, Yuxin Yang, Naside Gozde Durmus, James S Harris, Ronald W Davis
Isolation and characterization of rare cells and molecules from a heterogeneous population is of critical importance in diagnosis of common lethal diseases such as malaria, tuberculosis, HIV, and cancer. For the developing world, point-of-care (POC) diagnostics design must account for limited funds, modest public health infrastructure, and low power availability. To address these challenges, here we integrate microfluidics, electronics, and inkjet printing to build an ultra-low-cost, rapid, and miniaturized lab-on-a-chip (LOC) platform...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28166365/perampanel-in-12-patients-with-unverricht-lundborg-disease
#20
Arielle Crespel, Philippe Gelisse, Ngoc Phuong Loc Tang, Pierre Genton
OBJECTIVE: Perampanel (PER) was used in 12 patients with Unverricht-Lundborg disease (ULD) to evaluate its efficacy against myoclonus and seizures. METHODS: We treated 11 patients with EPM1 mutations (6 F, 5 M, aged 13-62 years) and a 43-year-old man with de novo KCNC1 mutation. PER was introduced by 2 mg steps at 2-4 week intervals until 6 mg/day, with a possible dose reduction or dose increase. RESULTS: Ten patients had a clear clinical response of myoclonus, and five were able to reduce concomitant therapy...
February 6, 2017: Epilepsia
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