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https://www.readbyqxmd.com/read/28432587/rituximab-methotrexate-procarbazine-vincristine-and-intensified-cytarabine-consolidation-for-primary-central-nervous-system-lymphoma-pcnsl-in-the-elderly-a-loc-network-study
#1
Caroline Houillier, Hervé Ghesquières, Cécile Chabrot, Carole Soussain, Guido Ahle, Sylvain Choquet, Emmanuelle Nicolas-Virelizier, Jacques-Olivier Bay, Jacques Vargaftig, Claude Gaultier, Valérie Touitou, Nadine Martin-Duverneuil, Nathalie Cassoux, Magali Le Garff-Tavernier, Myrto Costopoulos, Pierre Faurie, Khê Hoang-Xuan
Primary CNS lymphoma (PCNSL) is chemosensitive to high-dose methotrexate-based chemotherapy. However, responses in the elderly are short-lasting and outcome is poor. Given that radiotherapy and intensive chemotherapy expose elderly to severe toxicities, alternative consolidation approaches need to be evaluated. In this multicenter study, we retrospectively analyzed consecutive patients with newly-diagnosed PCNSL, aged >60, treated with a (R)-MPV-AAA regimen. The regimen consisted of three 28-day cycles of methotrexate (3...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28429068/nicotine-deprivation-elevates-neural-representation-of-smoking-related-cues-in-object-sensitive-visual-cortex-a-proof-of-concept-study
#2
Anne Havermans, Onno C P van Schayck, Eric F P M Vuurman, Wim J Riedel, Job van den Hurk
OBJECTIVE: In the current study, we use functional magnetic resonance imaging (fMRI) and multi-voxel pattern analysis (MVPA) to investigate whether tobacco addiction biases basic visual processing in favour of smoking-related images. We hypothesize that the neural representation of smoking-related stimuli in the lateral occipital complex (LOC) is elevated after a period of nicotine deprivation compared to a satiated state, but that this is not the case for object categories unrelated to smoking...
April 21, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28428150/satiety-regulation-in-children-with-loss-of-control-eating-and-attention-deficit-hyperactivity-disorder-a-test-meal-study
#3
Susanne Kurz, Dominik Schoebi, Daniela Dremmel, Wieland Kiess, Simone Munsch, Anja Hilbert
Children with loss of control (LOC) eating and attention-deficit/hyperactivity disorder (ADHD) are at risk for excessive weight gain. However, it is unclear whether or not these children show disturbances in hunger and satiety regulation. The goal was to examine the food intake and sense of LOC over eating as well as LOC eating-related characteristics during test meal in children with LOC eating and ADHD. Children aged 8-13 y with LOC eating (n = 33), ADHD (n = 32), and matched healthy controls (n = 33), consumed a test meal consisting of their chosen lunch food, with the instruction to eat until feeling full...
April 18, 2017: Appetite
https://www.readbyqxmd.com/read/28420518/acute-small-bowel-obstruction-caused-by-barbed-suture-on-the-second-day-after-laparoscopic-hysterosacropexy-a-case-report-and-literature-review
#4
Hsuan Chen, Mun-Kun Hong, Dah-Ching Ding
OBJECTIVE: To report a case of small bowel obstruction caused by barbed suture applied in hysterosacropexy, and possible solutions. CASE REPORT: A 57-year-old woman underwent laparoscopic hysterosacropexy for a Stage 2 uterine prolapse, presenting with acute abdominal pain and a bowel obstruction syndrome 2 days following the surgery. Conservative treatment was given, but the symptoms did not improve and gradually became worse. Diagnostic laparoscopy was performed on the 7(th) day after the hysterosacropexy, and the volvulus was found...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28410923/infrarenal-endograft-clamping-in-late-open-conversions-after-endovascular-abdominal-aneurysm-repair
#5
Paolo Perini, Alessandro de Troia, Tiziano Tecchio, Matteo Azzarone, Claudio Bianchini Massoni, Pierfranco Salcuni, Antonio Freyrie
OBJECTIVE: The aim of this study was to report the technical aspects and outcomes of late open conversion (LOC) after endovascular aneurysm repair (EVAR) in a single center by using exclusively infrarenal clamping of the endograft as an alternative to suprarenal or supraceliac aortic clamping. METHODS: A retrospective analysis of EVAR requiring late explantation (>30 days) from January 1996 to October 2016 was performed. Patients' demographics, type of endograft, duration of implantation, reason for removal, extent of stent graft removal, type of reconstruction, 30-day mortality, postoperative complications, and long-term survival were obtained for analysis...
April 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28410467/examination-of-the-interpersonal-model-of-loss-of-control-eating-in-the-laboratory
#6
Lisa M Shank, Ross D Crosby, Anne Claire Grammer, Lauren B Shomaker, Anna Vannucci, Natasha L Burke, Monika Stojek, Sheila M Brady, Merel Kozlosky, James C Reynolds, Jack A Yanovski, Marian Tanofsky-Kraff
BACKGROUND: The interpersonal model of loss of control (LOC) eating proposes that interpersonal problems lead to negative affect, which in turn contributes to the onset and/or persistence of LOC eating. Despite preliminary support, there are no data examining the construct validity of the interpersonal model of LOC eating using temporally sensitive reports of social stress, distinct negative affective states, and laboratory energy intake. METHOD: 117 healthy adolescent girls (BMI: 75th-97th %ile) were recruited for a prevention trial targeting excess weight gain in adolescent girls who reported LOC eating...
April 3, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28403704/nursing-management-of-reflex-anoxic-seizures-in-children
#7
Neal Patel, Rowan Kerr-Liddell, Louise Challis, Siba Prosad Paul
Children who present with transient loss of consciousness (T-LOC) are often first seen in emergency departments (EDs). Reflex anoxic seizure (RAS), vasovagal syncope and prolonged respiratory apnoea are benign, syncopal events that can be generally managed by explanation and reassurance. RAS is a short, paroxysmal, self-reverting episode of asystole that is triggered by pain, fear or anxiety and is caused by increased vagal response. It is an important differential diagnosis in pre-school age children who present with T-LOC, but is often underdiagnosed and can sometimes be misdiagnosed as epilepsy...
April 13, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28400222/self-reported-health-and-safety-awareness-improves-prediction-of-level-of-care-needs-in-veterans-discharged-from-a-post-acute-unit
#8
Julija Stelmokas, Linas A Bieliauskas, Katherine A Kitchen Andren, Robert Hogikyan, Neil B Alexander
OBJECTIVES: Evaluate the differential value of a self-reported health and safety awareness measure relative to other medical, psychosocial, and cognitive factors in predicting level of care (LOC) needs following hospital discharge. DESIGN: Retrospective medical record review. SETTING: Community Living Center Post-Acute Care (CLC-PAC) unit at a Veterans Affairs (VA) hospital. PARTICIPANTS: 175 Veterans admitted to the VA hospital or directly to the CLC-PAC from home...
April 8, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28399864/predictors-of-dental-visits-among-primary-school-children-in-the-rural-australian-community-of-lithgow
#9
James Rufus John, Haider Mannan, Subrat Nargundkar, Mario D'Souza, Loc Giang Do, Amit Arora
BACKGROUND: Regular dental attendance is significant in maintaining and improving children's oral health and well-being. This study aims to determine the factors that predict and influence dental visits in primary school children residing in the rural community of Lithgow, New South Wales (NSW), Australia. METHODS: All six primary schools of Lithgow were approached to participate in a cross-sectional survey prior to implementing water fluoridation in 2014. Children aged 6-13 years (n = 667) were clinically examined for their oral health status and parents were requested to complete a questionnaire on fluoride history, diet, last dental visit, and socio-demographic characteristics...
April 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28394576/group-6-layered-transition-metal-dichalcogenides-in-lab-on-a-chip-devices-1t-phase-ws2-for-microfluidics-non-enzymatic-detection-of-hydrogen-peroxide
#10
Rou Jun Toh, Carmen C Mayorga-Martinez, Jongyoon Han, Zdenek Sofer, Martin Pumera
Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) have been placed in the spotlight for their advantageous properties for catalytic and sensing applications. However, little work is done to explore and exploit them in enhancing the performance of analytical lab-on-a-chip (LOC) devices. In this work, we demonstrate a simple, sensitive, and low-cost fabrication of electrochemical LOC microfluidic devices to be used for enzymatic detection. We integrated four t-BuLi exfoliated, group 6 TMD materials (MoS2, MoSe2, WS2, and WSe2) within the LOC devices by the drop-casting method and compared their performance for H2O2 detection...
April 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28387552/predicting-recovery-patterns-after-sport-related-concussion
#11
Elizabeth F Teel, Stephen W Marshall, Viswanathan Shankar, Michael McCrea, Kevin M Guskiewicz
CONTEXT: Clinicians sometimes treat concussed individuals who have amnesia, loss of consciousness (LOC), a concussion history, or certain symptom types more conservatively, but it is unclear whether recovery patterns differ in individuals with these characteristics. OBJECTIVE: To determine whether (1) amnesia, LOC, and concussion history influence the acute recovery of symptoms, cognition, and balance; and (2) cognition and balance are influenced by acute symptom type...
March 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28378144/development-and-genetic-characterization-of-a-novel-herbicide-imazethapyr-tolerant-mutant-in-rice-oryza-sativa-l
#12
D Shoba, M Raveendran, S Manonmani, S Utharasu, D Dhivyapriya, G Subhasini, S Ramchandar, R Valarmathi, Nitasha Grover, S Gopala Krishnan, A K Singh, Pawan Jayaswal, Prashant Kale, M K Ramkumar, S V Amitha Mithra, T Mohapatra, Kuldeep Singh, N K Singh, N Sarla, M S Sheshshayee, M K Kar, S Robin, R P Sharma
BACKGROUND: Increased water and labour scarcity in major rice growing areas warrants a shift towards direct seeded rice cultivation under which management of weeds is a major issue. Use of broad spectrum non-selective herbicides is an efficient means to manage weeds. Availability of rice genotypes with complete tolerance against broad-spectrum non-selective herbicides is a pre-requisite for advocating use of such herbicides. In the present study, we developed an EMS induced rice mutant, 'HTM-N22', exhibiting tolerance to a broad spectrum herbicide, 'Imazethapyr', and identified the mutations imparting tolerance to the herbicide...
December 2017: Rice
https://www.readbyqxmd.com/read/28377175/tactile-object-categories-can-be-decoded-from-the-parietal-and-lateral-occipital-cortices
#13
Raúl Hernández-Pérez, Laura V Cuaya, Eduardo Rojas-Hortelano, Azalea Reyes-Aguilar, Luis Concha, Victor de Lafuente
The visual system classifies objects into categories, and distinct populations of neurons within the temporal lobe respond preferentially to objects of a given perceptual category. We can also classify the objects we recognize with the sense of touch, but less is known about the neuronal correlates underlying this cognitive function. To address this question, we performed a multivariate pattern analysis (MVPA) of functional magnetic resonance imagining (fMRI) activity to identify the cortical areas that can be used to decode the category of objects explored with the hand...
April 2, 2017: Neuroscience
https://www.readbyqxmd.com/read/28369540/the-2-o-methyladenosine-nucleoside-modification-gene-ostrm13-positively-regulates-salt-stress-tolerance-in-rice
#14
Youmei Wang, Dongqin Li, Junbao Gao, Xukai Li, Rui Zhang, Xiaohuan Jin, Zhen Hu, Bo Zheng, Staffan Persson, Peng Chen
Stress induces changes of modified nucleosides in tRNA, and these changes can influence codon-anticodon interaction and therefore the translation of target proteins. Certain nucleoside modification genes are associated with regulation of stress tolerance and immune response in plants. In this study, we found a dramatic increase of 2'-O-methyladenosine (Am) nucleoside in rice seedlings subjected to salt stress and abscisic acid (ABA) treatment. We identified LOC_Os03g61750 (OsTRM13) as a rice candidate methyltransferase for the Am modification...
March 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28362329/bench-top-fabrication-of-an-all-pdms-microfluidic-electrochemical-cell-sensor-integrating-micro-nanostructured-electrodes
#15
Sokunthearath Saem, Yujie Zhu, Helen Luu, Jose Moran-Mirabal
In recent years, efforts in the development of lab-on-a-chip (LoC) devices for point-of-care (PoC) applications have increased to bring affordable, portable, and sensitive diagnostics to the patients' bedside. To reach this goal, research has shifted from using traditional microfabrication methods to more versatile, rapid, and low-cost options. This work focuses on the benchtop fabrication of a highly sensitive, fully transparent, and flexible poly (dimethylsiloxane) (PDMS) microfluidic (μF) electrochemical cell sensor...
March 31, 2017: Sensors
https://www.readbyqxmd.com/read/28362224/prediction-of-periodontitis-occurrence-influence-of-the-classification-sociodemographic-and-general-health-information
#16
Fábio R M Leite, Karen G Peres, Loc G Do, Flávio F Demarco, Marco A Peres
BACKGROUND: Prediction of periodontitis development is challenging. Use of oral health related data alone, especially in young population might underestimate disease risk. This study investigated the accuracy of oral, systemic and socioeconomic data on estimating periodontitis development in a population-based prospective cohort. MATERIALS AND METHODS: General health and sociodemographic information were collected throughout the life-course of the individuals. Oral examinations were performed at ages 24 and 31 in the 1982 Pelotas cohort...
March 31, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28359998/too-much-to-handle-pesticide-dependence-of-smallholder-vegetable-farmers-in-southeast-asia
#17
Pepijn Schreinemachers, Hsiao-Pu Chen, Thi Tan Loc Nguyen, Borarin Buntong, Lilao Bouapao, Shriniwas Gautam, Nhu Thinh Le, Thira Pinn, Phimchai Vilaysone, Ramasamy Srinivasan
This study aimed to understand farmers' knowledge, attitudes, and practices regarding agricultural pest management and synthetic pesticide use in Southeast Asia. Data were used from 900 farm households producing leaf mustard (Brassica juncea (L.) Czern. et Coss.) and yard-long bean (Vigna unguiculata subsp. sesquipedalis (L.) Verdc.) in Cambodia, Laos and Vietnam. Farmers heavily depended on synthetic pesticides as their main method of pest control. Most farmers were aware of the adverse health effects associated with pesticide use and covered body parts while spraying, but also considered pesticides to be highly effective and indispensable farm inputs...
March 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28355306/genome-wide-association-analysis-identifies-resistance-loci-for-bacterial-blight-in-a-diverse-collection-of-indica-rice-germplasm
#18
Fan Zhang, Zhi-Chao Wu, Ming-Ming Wang, Fan Zhang, Michael Dingkuhn, Jian-Long Xu, Yong-Li Zhou, Zhi-Kang Li
Bacterial blight, which is caused by Xanthomonas oryzae pv. oryzae (Xoo), is one of the most devastating rice diseases worldwide. The development and use of disease-resistant cultivars have been the most effective strategy to control bacterial blight. Identifying the genes mediating bacterial blight resistance is a prerequisite for breeding cultivars with broad-spectrum and durable resistance. We herein describe a genome-wide association study involving 172 diverse Oryza sativa ssp. indica accessions to identify loci influencing the resistance to representative strains of six Xoo races...
2017: PloS One
https://www.readbyqxmd.com/read/28350897/transforming-concepts-into-clinical-trials-and-creating-a-multisite-network-the-leadership-and-operations-center-of-the-antibacterial-resistance-leadership-group
#19
Heather R Cross, Anthony Harris, Rebekka M Arias, Henry F Chip Chambers, Vance G Fowler
The Leadership and Operations Center (LOC) is responsible for facilitating, coordinating, and implementing the Antibacterial Resistance Leadership Group (ARLG) scientific agenda by engaging thought leaders; soliciting research proposals; and developing the processes, tools, and infrastructure required to operationalize studies and create and sustain the ARLG network. These efforts are ongoing as new projects are developed and the network expands and grows to address the ever-changing priorities in antibacterial resistance...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28345258/locus-of-control-and-frequency-of-physician-visits-results-of-a-population-based-longitudinal-study-in-germany
#20
André Hajek, Hans-Helmut König
OBJECTIVES: To examine the role of internal and external locus of control (LOC) in the frequency of physician visits longitudinally. DESIGN: A nationally representative, longitudinal cohort study of German households. Data were used from the years 2005 and 2010. METHODS: Data were gathered from the German Socio-Economic Panel (GSOEP). The ten internal and external LOC items in the SOEP are based on a scale by Krampen. The number of physician visits in the last 3 months was used as outcome variable...
March 27, 2017: British Journal of Health Psychology
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