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https://www.readbyqxmd.com/read/29214270/protein-separation-under-a-microfluidic-regime
#1
REVIEW
I Rodríguez-Ruiz, V Babenko, S Martínez-Rodríguez, J A Gavira
Lab-on-a-Chip (LoC), or micro-Total Analysis Systems (μTAS), is recognized as a powerful analytical technology with high capabilities, though end-user products for protein purification are still far from being available on the market. Remarkable progress has been achieved in the separation of nucleic acids and proteins using electrophoretic microfluidic devices, while pintsize devices have been developed for protein isolation according to miniaturized chromatography principles (size, charge, affinity, etc...
December 7, 2017: Analyst
https://www.readbyqxmd.com/read/29213229/reflex-modification-audiometry-reveals-dual-roles-for-olivocochlear-neurotransmission
#2
Paul D Allen, Anne E Luebke
Approximately 15% of American adults report some degree of difficulty hearing in a noisy environment or have auditory filtering difficulties. There are objective clinical tests of auditory filtering, yet few tests exist for mouse models that do not rely on extensive training. We have used reflex modification audiometry (RMA) and developed exclusion criteria for the mouse model. This RMA based test makes use of the acoustic startle response (ASR) and the ability of prepulses to inhibit the ASR [i.e., prepulse inhibition (PPI)] to assess the mouse's ability to detect prepulse signals presented in quiet or embedded in masking noise...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29196770/effect-of-gravity-acceleration-on-choroidal-and-retinal-nerve-fiber-layer-thickness-a-swept-source-optical-coherence-tomography-study
#3
Dong Yoon Kim, Jiho Song, Jin Young Kim, Kyungpil Choi, Sungmin Hyung, Ju Byung Chae
Purpose: The purpose of this study was to evaluate the effect of gravity acceleration on choroidal and retinal nerve fiber layer (RNFL) thickness using swept-source optical coherence tomography (SS-OCT). Methods: Thirteen healthy volunteers who planned to participate in human centrifuge training as part of the flight surgeon selection process enrolled this study. During centrifuge training, gravity was gradually increased up to six times that of sea level. All subjects underwent complete ophthalmologic examination and three-dimensional wide-scanning SS-OCT imaging (DRI OCT-1 Atlantis; Topcon, Tokyo, Japan)...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29196319/object-representations-in-human-visual-cortex-formed-through-temporal-integration-of-dynamic-partial-shape-views
#4
Tanya Orlov, Ehud Zohary
We typically recognize visual objects, by utilizing the spatial layout of their parts, simultaneously present on the retina. Thus, shape extraction is based on integration of the relevant retinal information over space. The lateral occipital complex (LOC) can faithfully represent shape in such conditions. However, sometimes, integration over time is required to determine object shape. To study shape extraction through temporal integration of successive partial-shape views, we presented human participants (both men and women) with artificial shapes that moved behind a narrow vertical or horizontal slit...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29185788/risk-factors-for-motorcycle-loss-of-control-crashes
#5
Dan Wu, Martine Hours, Jean-Louis Martin
OBJECTIVE: The present paper identifies and assesses the effect of critical factors on the risk of motorcycle loss-of-control (LOC) crashes. METHOD: Data come from a French project on road crashes, which comprises all fatal road crashes and a random sample of 1/20th of non-fatal crashes in France in 2011, based on police reports. A case-control study was carried out on a sample of 903 crashes for 444 LOC motorcycle riders (case) and 470 non-LOC and non-responsible motorcycle riders (control)...
November 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29182020/new-cycloartanes-and-new-iridoids-from-dolichandrone-spathacea-collected-in-the-mangrove-forest-of-soc-trang-province-vietnam
#6
Van Tuan Nguyen, Le Quyen Do, The Anh Nguyen, Tuan Thanh Nguyen, Van Loc Tran, Ngoc Anh Ho, Van Chien Tran, Van Sung Tran, Thi Phuong Thao Tran
Two new cycloartanes, named dolichandrone A (1) and dolichandrone B (2), as well as two new iridoids, named [6-O-[(E)-4-methoxycinnamoyl]-1β-hydroxy-dihydrocatalpolgenin (3) and 6-O-[(E)-4-methoxycinnamoyl]-1α-hydroxy-dihydrocatalpolgenin (4), together with four known iridoids (5-8), were isolated from the leaves and barks of Dolichandrone spathacea. Their structures were elucidated by means of extensive analysis of their HRESIMS, 1D and 2D NMR spectroscopic data. All of these compounds have been isolated for the first time from this plant...
November 28, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29181589/disentangling-brain-activity-related-to-the-processing-of-emotional-visual-information-and-emotional-arousal
#7
Michał Kuniecki, Kinga Wołoszyn, Aleksandra Domagalik, Joanna Pilarczyk
Processing of emotional visual information engages cognitive functions and induces arousal. We aimed to examine the modulatory role of emotional valence on brain activations linked to the processing of visual information and those linked to arousal. Participants were scanned and their pupil size was measured while viewing negative and neutral images. The visual noise was added to the images in various proportions to parametrically manipulate the amount of visual information. Pupil size was used as an index of physiological arousal...
November 27, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29164853/microfluidic-free-flow-electrophoresis-based-solvent-exchanger-for-continuously-operating-lab-on-chip-applications
#8
Franziska D Zitzmann, Heinz-Georg Jahnke, Simon Pfeiffer, Ronny Frank, Felix Nitschke, Laura Mauritz, Bernd Abel, Detlev Belder, Andrea A Robitzki
For miniaturization and integration of chemical synthesis and analytics on small length scales, the development of complex lab on chip (LOC) systems is in the focus of many current research projects. While application specific synthesis and analytic modules and LOC devices are widely described, the combination and integration of different modules is intensively investigated. Problems for in-line processes such as solvent incompatibilities, e.g., for a multistep synthesis or the combination of an organic drug synthesis with a cell-based biological activity testing system, require a solvent exchange between serialized modules...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29160072/solvent-controlled-branching-of-localized-versus-delocalized-singlet-exciton-states-and-equilibration-with-charge-transfer-in-a-structurally-well-defined-tetracene-dimer
#9
Jasper D Cook, Thomas J Carey, Dylan H Arias, Justin C Johnson, Niels H Damrauer
A detailed photophysical picture is elaborated for a structurally well-defined and symmetrical bis-tetracene dimer in solution. The molecule was designed for interrogation of the initial photophysical steps (S1 → (1)TT) in intramolecular singlet fission (SF). (Triisopropylsilyl)acetylene substituents on the dimer TIPS-BT1 as well as a monomer model TIPS-Tc enable a comparison of photophysical properties, including transient absorption dynamics, as solvent polarity is varied. In nonpolar toluene solutions, TIPS-BT1 decays via radiative and nonradiative pathways to the ground state with no evidence for dynamics related to the initial stages of SF...
November 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29158625/comparative-genomic-hybridization-and-transcriptome-sequencing-reveal-that-two-genes-osi_14279-loc_os03g62620-and-osi_10794-loc_os03g14950-regulate-the-mutation-in-the-%C3%AE-rl-rice-mutant
#10
Xulong Wang, Fanhua Wang, Huiqiong Chen, Xiaoyu Liang, Yingmei Huang, Jicai Yi
We previously established the genetic locus of the rolled-leaf mutant, γ-rl, to chromosome 3. In this study, we performed a comparative genomic hybridization (CGH) analysis to identify the genes responsible for the γ-rl mutant phenotype. This was combined with RNA transcriptome sequencing (RNA-seq) to analyze differences in the mRNA expression in seeds 12 h after germination. Using the reference genome of the "indica type" rice from GenBank, we created a chip with 386,000 high density DNA probes designed to target chromosome 3...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29149497/perceptions-of-general-and-postpresidential-election-discrimination-are-associated-with-loss-of-control-eating-among-racially-ethnically-diverse-young-men
#11
Nichole R Kelly, Tasia M Smith, Gordon C N Hall, Claire Guidinger, Gina Williamson, Elizabeth L Budd, Nicole R Giuliani
OBJECTIVE: The purpose of this study was to examine the association between young men's perceived experiences with discrimination, both general and following the 2016 presidential election, and their loss of control (LOC) eating. The degree to which men identified with their ethnic identity was evaluated as a moderator. METHOD: The sample included 798 men (18-30 years; M = 24.0 ± 3.6) who identified as African American (n = 261), Asian/Asian American (n = 266), or Hispanic/Latino (n = 271)...
November 17, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29146105/content-validation-of-behaviours-and-autonomic-responses-for-the-assessment-of-pain-in-critically-ill-adults-with-a-brain-injury
#12
Céline Gélinas, Kathleen A Puntillo, Madalina Boitor, Mélanie Bérubé, Jane Topolovec-Vranic, Anne-Sylvie Ramelet, Aaron M Joffe, Melissa Richard-Lalonde, Francis Bernard, David L Streiner
BACKGROUND: The evidence shows that brain-injured patients express behaviours that are related to their level of consciousness (LOC), and different from other patients in the intensive care unit (ICU). Therefore, existing behavioural scales should be revised to enhance their content and validity for use in these patients. OBJECTIVES: The aim was to evaluate the content relevance of behaviours and autonomic responses for pain assessment of brain-injured ICU patients from the perspective of critical care clinicians...
November 13, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29143298/a-single-nucleotide-mutation-of-ispf-gene-involved-in-the-mep-pathway-for-isoprenoid-biosynthesis-causes-yellow-green-leaf-phenotype-in-rice
#13
Rui Huang, Yang Wang, Pingrong Wang, Chunmei Li, Fuliang Xiao, Nenggang Chen, Na Li, Caixia Li, Changhui Sun, Lihua Li, Rongjun Chen, Zhengjun Xu, Jianqing Zhu, Xiaojian Deng
We identified IspF gene through yellow-green leaf mutant 505ys in rice. OsIspF was expressed in all tissues detected, and its encoded protein was targeted to the chloroplast. On expression levels of genes in this mutant, OsIspF itself and the genes encoding other enzymes of the MEP pathway and chlorophyll synthase were all up-regulated, however, among eight genes associated with photosynthesis, only psaA, psaN and psbA genes for three reaction center subunits of photosystem obviously changed. Isoprenoids are the most abundant natural compounds in all organisms, which originate from the basic five-carbon units isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)...
November 15, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/29138767/a-facile-method-for-urinary-phenylalanine-measurement-on-paper-based-lab-on-chip-for-pku-therapy-monitoring
#14
M A Messina, C Meli, S Conoci, S Petralia
A miniaturized paper-based lab-on-chip (LoC) was developed for the facile measurement of urinary Phe (phenylalanine) level on PKU (Phenylketonuria) treated patient. This system permits the monitoring of Phe in a dynamic range concentration of 20-3000 μM.
November 15, 2017: Analyst
https://www.readbyqxmd.com/read/29137200/a-lab-on-a-chip-based-non-invasive-optical-sensor-for-measuring-glucose-in-saliva
#15
Dong Geon Jung, Daewoong Jung, Seong Ho Kong
A lab-on-a-chip (LOC)-based non-invasive optical sensor for measuring glucose in saliva was fabricated. Existing glucose sensors utilizing blood require acquisition of a blood sample by pricking the finger, which is painful and inconvenient. To overcome these limitations, we propose a non-invasive glucose sensor with LOC, micro-electro-mechanical system and optical measurement technology. The proposed sensor for measuring glucose in saliva involves pretreatment, mixing, and measurement on a single tiny chip...
November 13, 2017: Sensors
https://www.readbyqxmd.com/read/29131592/a-paper-plastic-hybrid-microfluidic-device-for-smartphone-based-colorimetric-analysis-of-urine
#16
M Jalal Uddin, Gyeong Jun Jin, Joon Sub Shim
In this work, a disposable paper-plastic hybrid microfluidic lab-on-a-chip (LOC) has been developed and successfully applied for the colorimetric measurement of urine by the smartphone-based optical platform using an "UrineAnalysis" Android app. The developed device was cost-effectively implemented as a stand-alone hybrid LOC by incorporating the paper-based conventional reagent test strip inside the plastic-based LOC microchannel. The LOC device quantitatively investigated the small volume (40 µL) of urine analytes for the colorimetric reaction of glucose, protein, pH and red blood cell (RBC) in integration with the finger-actuating micro pump...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29130786/production-of-eurycomanone-from-cell-suspension-culture-of-eurycoma-longifolia
#17
Nguyen Huu Nhan, Nguyen Hoang Loc
CONTEXT: Eurycomanone is found in the Eurycoma longifolia Jack (Simaroubaceae) tree, exhibits significant antimalarial activity, improves spermatogenesis, suppresses expression of lung cancer cell tumour markers and regulates signalling pathways involved in proliferation, cell death and inflammation. OBJECTIVES: Establishment of cell suspension culture of E. longifolia to determine the eurycomanone accumulation during cultures. MATERIALS AND METHODS: Callus of E...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29129601/on-chip-signal-amplification-of-magnetic-bead-based-immunoassay-by-aviating-magnetic-bead-chains
#18
Uddin M Jalal, Gyeong Jun Jin, Kyu Shik Eom, Min Ho Kim, Joon S Shim
In this work, a Lab-on-a-Chip (LOC) platform is used to electromagnetically actuate magnetic bead chains for an enhanced immunoassay. Custom-made electromagnets generate a magnetic field to form, rotate, lift and lower the magnetic bead chains (MBCs). The cost-effective, disposable LOC platform was made with a polymer substrate and an on-chip electrochemical sensor patterned via the screen-printing process. The movement of the MBCs is controlled to improve the electrochemical signal up to 230% when detecting beta-type human chorionic gonadotropin (β-hCG)...
November 6, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29127692/coagulation-measurement-from-whole-blood-using-vibrating-optical-fiber-in-a-disposable-cartridge
#19
Yusuf Samet Yaraş, Ali Bars Gündüz, Gökhan Sağlam, Selim Ölçer, Fehmi Civitçi, İbrahim Baris, Göksenin Yaralioğlu, Hakan Urey
In clinics, blood coagulation time measurements are performed using mechanical measurements with blood plasma. Such measurements are challenging to do in a lab-on-a-chip (LoC) system using a small volume of whole blood. Existing LoC systems use indirect measurement principles employing optical or electrochemical methods. We developed an LoC system using mechanical measurements with a small volume of whole blood without requiring sample preparation. The measurement is performed in a microfluidic channel where two fibers are placed inline with a small gap in between...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29125731/imaging-pd-l1-expression-with-immunopet
#20
Charles Truillet, Hsueh Ling J Oh, Siok Ping Yeo, Chia-Yin Lee, Loc T Huynh, Junnian Wei, Matthew F L Parker, Collin Blakely, Natalia Sevillano, Yung-Hua Wang, Yuqin S Shen, Victor Olivas, Khaled M Jami, Anna Moroz, Benoit Jego, Emilie Jaumain, Lawrence Fong, Charles S Craik, Albert J Chang, Trever G Bivona, Cheng-I Wang, Michael J Evans
High sensitivity imaging tools could provide a more holistic view of target antigen expression to improve the identification of patients who might benefit from cancer immunotherapy. We developed for immunoPET a novel recombinant human IgG1 (termed C4) that potently binds an extracellular epitope on human and mouse PD-L1 and radiolabeled the antibody with zirconium-89. Small animal PET/CT studies showed that (89)Zr-C4 detected antigen levels on a patient derived xenograft (PDX) established from a non-small-cell lung cancer (NSCLC) patient before an 8-month response to anti-PD-1 and anti-CTLA4 therapy...
November 15, 2017: Bioconjugate Chemistry
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