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Vamsi K Yenamandra, Shamsudheen K Vellarikkal, Manoj Kumar, Madhumita R Chowdhury, Rijith Jayarajan, Ankit Verma, Vinod Scaria, Sridhar Sivasubbu, Subrata B Ray, Amit K Dinda, Madhulika Kabra, Punit Kaur, Vinod K Sharma, Gomathy Sethuraman
BACKGROUND: Junctional epidermolysis bullosa (JEB) is a diverse group of genodermatoses associated with extreme skin fragility. Despite several well-characterized genetic studies, molecular diagnosis of this heterogeneous group is still challenging. Recent advances in the field of genomics have seen the successful implementation of whole exome sequencing (WES) as a fast and efficient diagnostic strategy in several genodermatoses. OBJECTIVE: In view of the scarcity and need of molecular studies for JEB in India, we sought to explore the potential of WES in understanding the mutational spectrum of this rare, in certain subtypes lethal, sub-group of EB...
December 29, 2016: Journal of Dermatological Science
Soudabeh Mashhadi, Dinh Loc Duong, Marko Burghard, Klaus Kern
Tuning the electron and phonon transport properties of thermoelectric materials by nanostructuring has enabled improving their thermopower figure of merit. Three-dimensional topological insulators, including many bismuth chalcogenides, attract increasing attention for this purpose, as their topologically protected surface states are promising to further enhance the thermoelectric performance. While individual bismuth chalcogenide nanostructures have been studied with respect to their photothermoelectric properties, nanostructured p-n junctions of these compounds have not yet been explored...
January 11, 2017: Nano Letters
Ziyan Chen, Xianchai Lin, Bo Qu, Wuyou Gao, Yajing Zuo, Wenyan Peng, Ling Jin, Minbin Yu, Ecosse Lamoureux
PURPOSE: To investigate the relationship between preoperative expectations and actual postoperative outcomes of visual function (VF) among patients undergoing first eye cataract surgery. METHODS: A longitudinal study of 182 patients from hospitals in urban Southern China were surveyed prior to surgery and 3 month after cataract surgery regarding their preoperative, expected postoperative and actual postoperative VF for each of the items on the Catquest-9SF and their satisfaction with cataract surgery...
2017: PloS One
Audrey McKinlay, John D Corrigan, Jennifer A Bogner, L John Horwood
OBJECTIVE: To investigate the concordance between medically documented childhood traumatic brain injury (TBI) and recall of same by adults aged 35 years. PARTICIPANTS: A total of 962 birth cohort members from the Christchurch Health and Development Study available at the 35-year follow-up. MAIN MEASURES: Childhood TBI information prospectively collected yearly over ages 0 to 15 years as part of the Christchurch Health and Development Study...
January 5, 2017: Journal of Head Trauma Rehabilitation
Guro Hanevold Bjørkløf, Knut Engedal, Geir Selbæk, Deborah Bezerra Maia, Tom Borza, Jūratė Šaltytė Benth, Anne-Sofie Helvik
OBJECTIVES: Treatment of depression (in late life) is good. The short-term, but not long-term prognosis after treatment of depression in late life is good. To identify modifiable factors, we wanted to examine whether coping in terms of locus of control and coping strategies in depressed patients were associated with the prognosis of depression at follow-up, adjusted for sociodemographic information and health variables. METHOD: In total, 122 patients (mean age 75...
January 4, 2017: Aging & Mental Health
T Ritter, B Schultz, G Kim, M Barnes, M Perez, K Farrey, R Popple, P Greer, J Moran
PURPOSE: The MLC dosimetric leaf gap (DLG) and transmission are measured parameters which impact the dosimetric accuracy of IMRT and VMAT plans. This investigation aims to develop an efficient and accurate routine constancy check of the physical DLG in two dimensions. METHODS: The manufacturer's recommended DLG measurement method was modified by using 5 fields instead of 11 and by utilizing the Electronic Portal Imaging Device (EPID). Validations were accomplished using an ion chamber (IC) in solid water and a 2D IC array...
June 2016: Medical Physics
Dinh Loc Duong, Gihun Ryu, Alexander Hoyer, Chengtian Lin, Marko Burghard, Klaus Kern
Raman scattering is a powerful tool for investigating the vibrational properties of two-dimensional materials. Unlike the 2H phase of many transition metal dichalcogenides, the 1T phase of TiSe2 features a Raman-active shearing and breathing mode, both of which shift toward lower energy with increasing number of layers. By systematically studying the Raman signal of 1T-TiSe2 in dependence of the sheet thickness, we demonstrate that the charge density wave transition of this compound can be reliably determined from the temperature dependence of the peak position of the Eg mode near 136 cm(-1)...
January 10, 2017: ACS Nano
Jinbo He, Zhihui Cai, Xitao Fan
OBJECTIVE: Due to the inconsistency of the research findings in the current literature, the prevalence of binge and loss of control (LOC) eating among children and adolescents with overweight and obesity remains unclear. By using the meta-analytic approach, this article aimed at exploring the prevalence of binge/LOC eating among children and adolescents with overweight and obesity, and at identifying potential moderators, which may have contributed to the heterogeneity of the existing research findings...
December 30, 2016: International Journal of Eating Disorders
Helena Silveira Schuch, Karen G Peres, Ankur Singh, Marco A Peres, Loc G Do
Socioeconomic position (SEP) is a well-known risk indicator for chronic periodontitis. However, it is still unclear how SEP during the life course influences periodontal outcomes in adulthood. This study aimed to systematically review longitudinal studies investigating the influence of individual-level SEP during the life course on subsequent periodontitis in adulthood. Inclusion criteria were epidemiological longitudinal observational studies, in which indicators of relative SEP were assessed prior to clinical assessment of periodontitis...
December 29, 2016: Community Dentistry and Oral Epidemiology
Chiming Gu, Yi Liu, Ibrahim Mohamed, Runhua Zhang, Xiao Wang, Xinxin Nie, Min Jiang, Margot Brooks, Fang Chen, Zhiguo Li
Mulching management has been used in many places all over the world to improve agricultural sustainability. However, the cycling of carbon in the soil under applications of mulch on sloping arable land is not yet fully understood. A four-year field experiment was carried out in Xiaofuling watershed of Danjiangkou reservoir in China. The object was to evaluate the effects of the application of straw mulch (ST) and grass mulch (GT) on dynamic changes in soil organic carbon and its fractions. Results showed that mulch applied on the soil surface increased the contents of SOC and its active fractions in the soil...
2016: PloS One
Charles Truillet, John T Cunningham, Matthew F L Parker, Loc T Huynh, Crystal S Conn, Davide Ruggero, Jason S Lewis, Michael J Evans
PURPOSE: mTOR regulates many normal physiological processes and when hyperactive, can drive numerous cancers and human diseases. However, it is very challenging to detect and quantify mTOR signaling non-invasively in clinically relevant animal models of disease or man. We hypothesized that a nuclear imaging tool measuring intracellular mTOR activity could address this unmet need. EXPERIMENTAL DESIGN: Although the biochemical activity of mTOR is not directly amenable to nuclear imaging probe development, we show that the transferrin receptor can be used to indirectly measure intracellular changes in mTOR activity...
December 22, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Jane Topolovec-Vranic, Andree Schuler, Agnes Gozdzik, Julian Somers, Paul-Émile Bourque, C James Frankish, Jalila Jbilou, Sarah Pakzad, Luis Ivan Palma Lazgare, Stephen W Hwang
OBJECTIVE: characterize the prevalence of self-reported head injury with loss of consciousness (LOC) and associated demographic, clinical and service use factors in a sample of homeless adults with mental illness. METHOD: Participants in the At Home/Chez Soi study were interviewed at the time of study enrollment regarding their history of head injuries, mental and physical health diagnoses and justice system and healthcare interactions. Sociodemographic and clinical data were also collected...
December 3, 2016: Journal of Psychiatric Research
Zachary B Millman, Marc J Weintraub, Eryn Bentley, Jordan E DeVylder, Vijay A Mittal, Steven C Pitts, Elizabeth Thompson, Caroline Demro, Gloria M Reeves, Jason Schiffman
Research suggests that perceived social stress influences illness presentation and course among youth in the clinical high-risk (CHR) phase of psychosis. Little is known, however, about the social cognitive factors associated with social stress perception in this population, particularly relative to youth with non-CHR psychopathology. Individuals with psychosis tend to endorse an external locus of control (LOC), which is associated with the stress response in healthy individuals. LOC may therefore be related to perceived social stress in youth at CHR...
December 17, 2016: Schizophrenia Research
Quoc Toan Phan, Tom Kompier
Coeliccia hayashii sp. nov. (holotype male, from Doi waterfall, KaNat, K'Bang district, Gia Lai Province, central Vietnam, deposited in VNMN) and Coeliccia mattii sp. nov. (holotype male and female allotype, from Doi Cao, Loc Tan, Bao Lam district, Lam Dong Province, southern Vietnam, deposited in VNMN) are described. The males of both species are characterized by extensive pruinosity on the thorax.
November 23, 2016: Zootaxa
Zoi Thrapsanioti, Panagiotis Askounis, Ioannis Datseris, Ramza Anastasia Diamanti, Miltiadis Papathanasiou, Eleftheria Carinou
The lens of the eye is one of the radiosensitive tissues of the human body; if exposed to ionizing radiation can develop radiation-induced cataract at early ages. This study was held in Greece and included 44 Interventional Cardiologists (ICs) and an unexposed to radiation control group of 22 persons. Of the note, 26 ICs and the unexposed individuals underwent special eye examinations. The detected lens opacities were classified according to LOCS III protocol. Additionally, the lens doses of the ICs were measured using eye lens dosemeters...
December 15, 2016: Radiation Protection Dosimetry
Hao Chen, Yanyan Tang, Jianfeng Liu, Lubin Tan, Jiahuang Jiang, Mumu Wang, Zuofeng Zhu, Xianyou Sun, Chuanqing Sun
Grain number is an important factor in determining grain production of rice (Oryza sativa L.). The molecular genetic basis for grain number is complex. Discovering new genes involved in regulating rice grain number increases our knowledge regarding its molecular mechanisms and aids breeding programs. Here, we identified GRAINS NUMBER 2 (GN2), a novel gene that is responsible for rice grain number, from 'Yuanjiang' common wild rice (Oryza rufipogon Griff.). Transgenic plants over-expressing GN2 showed less grain number, reduced plant height, and later heading date than control plants...
December 16, 2016: Genetics
Paul Haynes
Re-circulating underwater breathing apparatus (rebreathers) have become increasingly popular amongst sport divers. In comparison to open-circuit scuba, rebreathers are complex life support equipment that incorporates many inherent failure modes and potential for human error. This individually or in combination can lead to an inappropriate breathing gas. Analysis of rebreather diving incidents suggests that inappropriate breathing gas is the most prevalent disabling agent. This can result in spontaneous loss of consciousness (LoC), water aspiration and drowning...
December 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Roberto Urcuyo, Dinh Loc Duong, Patrick Sailer, Marko Burghard, Klaus Kern
No abstract text is available yet for this article.
December 14, 2016: Nano Letters
Birgitte K Hønsvall, Lucy J Robertson
Nucleic acid sequence-based amplification (NASBA) is a sensitive and efficient molecular tool for amplification of RNA and has been widely adopted in clinical diagnostics. Monitoring of water and other environmental samples demands sensitive techniques, as potential pathogens may be in low concentrations and require only a few infectious units to infect their host. NASBA has qualities that should be advantageous for analysis of environmental samples, such as short reaction times, high sensitivity, and not readily affected by inhibitory substances that are often abundant in environmental samples...
February 1, 2017: Water Research
Maren Praß, Cathleen Grimsen, Manfred Fahle
Object agnosia is a rare symptom, occurring mainly after bilateral damage of the ventral visual cortex. Most patients suffering from unilateral ventral lesions are clinically non-agnosic. Here, we studied the effect of unilateral occipito-temporal lesions on object categorization and its underlying neural correlates in visual areas. Thirteen non-agnosic stroke patients and twelve control subjects performed an event-related rapid object categorization task in the fMRI scanner where images were presented either to the left or to the right of a fixed point...
December 9, 2016: Neuropsychologia
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