Amin Ziaei, Olivia Solomon, T Charles Casper, Michael Waltz, Bianca Weinstock-Guttman, Greg Aaen, Yolanda Wheeler, Jennifer Graves, Leslie Benson, Mark Gorman, Mary Rensel, Soe Mar, Tim Lotze, Benjamin Greenberg, Tanuja Chitnis, Amy T Waldman, Lauren Krupp, Judith A James, Janace Hart, Lisa F Barcellos, Emmanuelle Waubant
BACKGROUND AND OBJECTIVE: Prior Epstein-Barr virus (EBV) infection is associated with an increased risk of pediatric-onset multiple sclerosis (POMS) and adult-onset multiple sclerosis (MS). It has been challenging to elucidate the biological mechanisms underlying this association. We examined the interactions between candidate human leukocyte antigen (HLA) and non-HLA variants and childhood EBV infection as it may provide mechanistic insights into EBV-associated MS. METHODS: Cases and controls were enrolled in the Environmental and Genetic Risk Factors for Pediatric MS study of the US Network of Pediatric MS Centers...
February 9, 2024: Multiple Sclerosis: Clinical and Laboratory Research