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https://www.readbyqxmd.com/read/28092172/analysis-of-indium-tin-oxide-film-using-argon-fluroide-arf-laser-excited-atomic-fluorescence-of-ablated-plumes
#1
Sut Kam Ho, Dario Machado Garcia
A two-pulse laser-excited atomic fluorescence (LEAF) technique at 193 nm wavelength was applied to the analysis of indium tin oxide (ITO) layer on polyethylene terephthalate (PET) film. Fluorescence emissions from analytes were induced from plumes generated by first laser pulse. Using this approach, non-selective LEAF can be accomplished for simultaneous multi-element analysis and it overcomes the handicap of strict requirement for laser excitation wavelength. In this study, experimental conditions including laser fluences, times for gating and time delay between pulses were optimized to reveal high sensitivity with minimal sample destruction and penetration...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28091979/blood-perfusion-in-osteomyelitis-studied-with-15-o-water-pet-in-a-juvenile-porcine-model
#2
Lars Jødal, Ole L Nielsen, Pia Afzelius, Aage K O Alstrup, Søren B Hansen
BACKGROUND: Osteomyelitis is a serious disease which can be difficult to treat despite properly instituted antibiotic therapy. This appears to be related at least partly to degraded vascularisation in the osteomyelitic (OM) lesions. Studies of perfusion in OM bones are, however, few and not quantitative. Quantitative assessment of perfusion could aid in the selection of therapy. A non-invasive, quantitative way to study perfusion is dynamic [(15)O]water positron emission tomography (PET)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28091978/patient-specific-optimisation-of-administered-activity-and-acquisition-times-for-18-f-fdg-pet-imaging
#3
Fred Wickham, Helena McMeekin, Maria Burniston, Daniel McCool, Deborah Pencharz, Annah Skillen, Thomas Wagner
BACKGROUND: The purpose of this study is to identify a method for optimising the administered activity and acquisition time for (18)F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes and compositions, while limiting radiation doses to patients and staff. Patients referred for FDG scans had bioimpedance measurements. They were injected with 3 MBq/kg of (18)F up to 370 MBq and scanned on a Siemens Biograph mCT at 3 or 4 min per bed position...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28091957/point-spread-function-reconstructed-pet-images-of-sub-centimeter-lesions-are-not-quantitative
#4
O L Munk, L P Tolbod, S B Hansen, T V Bogsrud
BACKGROUND: PET image reconstruction methods include modeling of resolution degrading phenomena, often referred to as point-spread function (PSF) reconstruction. The aim of this study was to develop a clinically relevant phantom and characterize the reproducibility and accuracy of high-resolution PSF reconstructed images of small lesions, which is a prerequisite for using PET in the prediction and evaluation of responses to treatment. Sets of small homogeneous (18)F-spheres (range 3-12 mm diameter, relevant for small lesions and lymph nodes) were suspended and covered by a (11)C-silicone, which provided a scattering medium and a varying sphere-to-background ratio...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28091771/localization-of-parathyroid-adenomas-using-11-c-methionine-pet-after-prior-inconclusive-imaging
#5
Milou E Noltes, Annemieke M Coester, Anouk N A van der Horst-Schrivers, Bart Dorgelo, Liesbeth Jansen, Walter Noordzij, Clara Lemstra, Adrienne H Brouwers, Schelto Kruijff
PURPOSE: Minimally invasive parathyroidectomy (MIP) is the recommended treatment in primary hyperparathyroidism (pHPT) for which accurate preoperative localization is essential. The current imaging standard consists of cervical ultrasonography (cUS) and MIBI-SPECT/CT. (11)C-MET PET/CT has a higher resolution than MIBI-SPECT/CT. The aim of this study was to determine the diagnostic performance of (11)C-MET PET/CT after initial inconclusive or negative localization. METHODS: We performed a retrospective single center cohort study of patients with pHPT undergoing parathyroid surgery after prior negative imaging and later localization by means of (11)C-MET PET/CT between 2006 and 2014...
January 14, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28091733/post-treatment-pet-ct-and-p16-status-for-predicting-treatment-outcomes-in-locally-advanced-head-and-neck-cancer-after-definitive-radiation
#6
Musaddiq J Awan, Pierre Lavertu, Chad Zender, Rod Rezaee, Nicole Fowler, Lilit Karapetyan, Michael Gibson, Jay Wasman, Peter Faulhaber, Mitchell Machtay, Min Yao
PURPOSE: To retrospectively review post-treatment (post-tx) FDG-PET/CT scans in patients with advanced head and neck squamous cell carcinoma (HNSCC) and known p16 status, treated with definitive (chemo)radiation (RT). METHODS: A total of 108 eligible patients had N2A or greater HNSCC treated with chemoRT from August 1, 2008, to February 28, 2015, with post-tx PET/CT within 6 months after RT. Kaplan-Meier curves, log-rank statistics, and Cox proportional hazards regression were used for statistical analysis...
January 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28091604/polyglucose-nanoparticles-with-renal-elimination-and-macrophage-avidity-facilitate-pet-imaging-in-ischaemic-heart-disease
#7
Edmund J Keliher, Yu-Xiang Ye, Gregory R Wojtkiewicz, Aaron D Aguirre, Benoit Tricot, Max L Senders, Hannah Groenen, Francois Fay, Carlos Perez-Medina, Claudia Calcagno, Giuseppe Carlucci, Thomas Reiner, Yuan Sun, Gabriel Courties, Yoshiko Iwamoto, Hye-Yeong Kim, Cuihua Wang, John W Chen, Filip K Swirski, Hsiao-Ying Wey, Jacob Hooker, Zahi A Fayad, Willem J M Mulder, Ralph Weissleder, Matthias Nahrendorf
Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with (18)F-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28091565/-18-f-flt-and-18-f-fdg-pet-ct-in-predicting-response-to-chemoradiotherapy-in-nasopharyngeal-carcinoma-preliminary-results
#8
Shi Qi, Yang Zhongyi, Zhang Yingjian, Hu Chaosu
The purpose of this study was to explore the feasibility of (18)F-Fluorothymidine ((18)F-FLT) and (18)F-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in predicting treatment response of nasopharyngeal carcinoma (NPC). Patients with NPC of Stage II-IVB were prospectively enrolled, receiving 2 cycles of neoadjuvant chemotherapy (NACT), followed by concurrent chemoradiotherapy. Each patient underwent pretreatment and post-NACT FLT PET/CT and FDG PET/CT. Standard uptake values (SUV) and tumor volume were measured...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091338/molecular-epidemiological-analysis-to-assess-the-influence-of-pet-ownership-in-the-biodiversity-of-staphylococcus-aureus-and-mrsa-in-dog-and-non-dog-owning-healthy-households
#9
J C VAN Balen, T Landers, E Nutt, A Dent, A E Hoet
It has been suggested that zoonotic transmission of Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) can occur between owners and their pets within the same household. However, the influence that pet-ownership could have in the biodiversity of SA/MRSA strains circulating among owners is not fully understood. The objective of this study was to perform a molecular epidemiological analysis to evaluate and compare the biodiversity of SA/MRSA strains in dog-owning and non-dog-owning healthy households within the same community...
January 16, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28090641/in-vivo-quantitative-assessment-of-the-therapeutic-response-in-a-mouse-model-of-collagen-induced-arthritis-using-18-f-fluorodeoxyglucose-positron-emission-tomography
#10
Anupam Mitra, Smriti Kundu-Raychaudhuri, Christine Abria, Angelica Rona, Abhijit J Chaudhari, Siba P Raychaudhuri
BACKGROUND: Mouse collagen induced arthritis (CIA) is the most commonly used animal model to investigate underlying pathogenesis of autoimmune arthritis and to demonstrate therapeutic efficacy of novel drugs in autoimmune arthritis. The conventional read out of CIA are clinical score and histopathology, which have several limitations including (i) subjected to observer bias; (ii) longitudinal therapeutic efficacy of a new drug cannot be determined. Thus a robust, non-invasive, in vivo drug screening tool is currently an unmet need...
January 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28090627/fdg-pet-for-early-response-assessment-in-lymphomas-part-2-diffuse-large-b-cell-lymphoma-use-of-quantitative-pet-evaluation
#11
REVIEW
Bruce D Cheson, Lale Kostakoglu
In Part 1, we reviewed the role of interim positron emission tomography (PET)/CT scans in Hodgkin lymphoma. In advanced Hodgkin lymphoma, interim PET is a useful prognostic tool that can be used to implement risk-adapted therapy with potential benefits for both patients who have negative interim scans and those whose scans are positive. Interim PET/CT has not shown as encouraging results in diffuse large B-cell lymphoma (DLBCL), with the exception of germinal center B-cell DLBCL. Thus, quantitative methods of interpreting interim PET scans have been pursued in an effort to improve their predictive value...
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090622/fdg-pet-for-early-response-assessment-in-lymphomas-part-1-hodgkin-lymphoma
#12
REVIEW
Bruce D Cheson, Lale Kostakoglu
Interim positron emission tomography (PET)/CT has shown encouraging results when used as a prognostic tool early in the course of treatment of advanced Hodgkin lymphoma, allowing for a reduction in treatment for patients with favorable characteristics, while suggesting a benefit from changing therapy for those with a positive scan. For patients with limited disease, a negative scan allows for a decrease in treatment; however, the benefits for those patients whose scans are positive are less certain. Here we critically analyze the role of PET/CT in the early assessment of Hodgkin lymphoma...
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090451/potential-of-pet-mri-for-imaging-of-non-oncologic-musculoskeletal-disease
#13
REVIEW
Feliks Kogan, Audrey P Fan, Garry E Gold
Early detection of musculoskeletal disease leads to improved therapies and patient outcomes, and would benefit greatly from imaging at the cellular and molecular level. As it becomes clear that assessment of multiple tissues and functional processes are often necessary to study the complex pathogenesis of musculoskeletal disorders, the role of multi-modality molecular imaging becomes increasingly important. New positron emission tomography-magnetic resonance imaging (PET-MRI) systems offer to combine high-resolution MRI with simultaneous molecular information from PET to study the multifaceted processes involved in numerous musculoskeletal disorders...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090276/overexpression-of-recombinant-human-teriparatide-rhpth-1-34-in-escherichia-coli-an-innovative-gene-fusion-approach
#14
Nahid Bakhtiari, Zahra Amini Bayat, Sepideh Sagharidouz, Mohsen Vaez
BACKGROUND: Parathyroid hormone is an 84-amino acid peptide secreted by the parathyroid glands. Its physiological role is maintenance of normal serum calcium level and bone remodeling. Biological activity of this hormone is related to N-terminal 1-34 amino acids. The recombinant form of hormone (1-34) has been approved for treatment of osteoporosis from 2002. In this study, a novel fusion partner has been developed for preparation of high yield recombinant 1-34 amino acids of hPTH. METHODS: Novel nucleotide cassette designed encoding a chimeric fusion protein comprising of a fusion partner consisting of a His-tag in N-terminal, 53 amino acids belong to Escherichia coli (E...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28089955/is-integrated-18f-fdg-pet-mri-superior-to-18f-fdg-pet-ct-in-the-differentiation-of-incidental-tracer-uptake-in-the-head-and-neck-area
#15
Benedikt Michael Schaarschmidt, Benedikt Gomez, Christian Buchbender, Johannes Grueneisen, Felix Nensa, Lino Morris Sawicki, Verena Ruhlmann, Axel Wetter, Gerald Antoch, Philipp Heusch
PURPOSE: We aimed to investigate the accuracy of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) compared with contrast-enhanced 18F-FDG PET/computed tomography (PET/CT) for the characterization of incidental tracer uptake in examinations of the head and neck. METHODS: A retrospective analysis of 81 oncologic patients who underwent contrast-enhanced 18F-FDG PET/CT and subsequent PET/MRI was performed by two readers for incidental tracer uptake...
January 16, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28089678/reduced-effects-of-age-on-dopamine-d2-receptor-levels-in-physically-active-adults
#16
Linh C Dang, Jaime J Castrellon, Scott F Perkins, Nam T Le, Ronald L Cowan, David H Zald, Gregory R Samanez-Larkin
Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.
January 9, 2017: NeuroImage
https://www.readbyqxmd.com/read/28089381/pet-ct-underlying-physics-instrumentation-and-advances
#17
I Torres Espallardo
Since it was first introduced, the main goal of PET/CT has been to provide both PET and CT images with high clinical quality and to present them to radiologists and specialists in nuclear medicine as a fused, perfectly aligned image. The use of fused PET and CT images quickly became routine in clinical practice, showing the great potential of these hybrid scanners. Thanks to this success, manufacturers have gone beyond considering CT as a mere attenuation corrector for PET, concentrating instead on design high performance PET and CT scanners with more interesting features...
January 12, 2017: Radiología
https://www.readbyqxmd.com/read/28089190/positron-emission-tomography-in-the-management-of-documented-or-suspected-recurrent-ovarian-cancer
#18
Hung-Hsueh Chou, Chao-Yu Chen, Feng-Yuan Liu, Gigin Lin, Chun-Chieh Wang, Lan-Yan Yang, Min-Yu Chen, Yu-Bin Pan, Ren-Chin Wu, Tzu-Chen Yen, Ting-Chang Chang, Chyong-Huey Lai
BACKGROUND: To prospectively evaluate the value of positron emission tomography (PET) or integrated computed tomography (CT) and PET (PET/CT) in the management of documented or suspected recurrent ovarian cancer. METHODS: Patients with ovarian cancer who had completed primary cytoreductive surgery and standard adjuvant chemotherapy were studied to evaluate the following indications: (1) CA125 elevation after complete remission with negative CT or magnetic resonance imaging (MRI) result; (2) post-therapy surveillance CT/MRI-detected suspicious lesions that guided biopsy was not feasible; (3) documented relapse for restaging prior to or after curative salvage therapy...
January 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28088979/-value-of-pet-ct-clinical-application-in-extranodal-nk-t-cell-lymphoma
#19
S R Yang, X L Lan
No abstract text is available yet for this article.
December 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28088881/an-industry-update-the-latest-developments-in-therapeutic-delivery
#20
Iain Simpson
This Industry Update covers the period from 1 October through to 31 October 2016, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw several news items covering drug-delivery devices, including a new sensor to monitor and support the use of inhalers; launch in the UK of a new autoinjector for Cimzia(®), UCB's rheumatoid arthritis drug; and approval of Roche's Lucentis(®) in a prefilled syringe. Research was also published to show the value of continuous blood pressure monitoring in dementia management...
February 2017: Therapeutic Delivery
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