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https://www.readbyqxmd.com/read/28938677/comparison-of-18-fdg-pet-pet-ct-and-bone-scintigraphy-for-detecting-bone-metastases-in-patients-with-nasopharyngeal-cancer-a-meta-analysis
#1
Chuanhui Xu, Ruiming Zhang, Huanlei Zhang, Zhenyan Zhang
OBJECTIVE: We performed a meta-analysis to compare the diagnostic efficacy of (18)FDG PET/PET-CT and bone scintigraphy (BS) for diagnosing bone metastatic cancers in nasopharyngeal cancer patients. RESULTS: 6 studies (1238 patients) fulfilled the inclusion criteria. The pooled sensitivities for (18)FDG PET/PET-CT and BS were 0.81 (95% confidence interval [CI] = 0.70 to 0.98) and 0.39 (95% CI = 0.26 to 0.54), specificities were 0.99 (95% CI = 0.98 to 0.99) and 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938220/metabolic-correlate-of-memory-deficit-awareness-in-dementia-with-lewy-bodies-implication-in-cortical-midline-structure
#2
Tomomichi Iizuka, Masashi Kameyama
The neural substrate of memory-deficit awareness has been studied in mild cognitive impairment and Alzheimer's disease (AD). However, little is known about that in dementia with Lewy bodies (DLB). To determine the neural substrates of memory-deficit awareness in DLB, we investigated the relationship between awareness of memory-deficit and glucose metabolism in DLB. Thirty-four patients with DLB were assessed by (18)F-FDG-PET and dopamine transporter (DAT)-SPECT. The awareness was evaluated using an awareness index that represents the discrepancy between objective and subjective memory scores...
September 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28938143/contribution-of-transcranial-magnetic-stimulation-to-assessment-of-brain-connectivity-and-networks
#3
REVIEW
Mark Hallett, Riccardo Di Iorio, Paolo Maria Rossini, Jung E Park, Robert Chen, Pablo Celnik, Antonio P Strafella, Hideyuki Matsumoto, Yoshikazu Ugawa
The goal of this review is to show how transcranial magnetic stimulation (TMS) techniques can make a contribution to the study of brain networks. Brain networks are fundamental in understanding how the brain operates. Effects on remote areas can be directly observed or identified after a period of stimulation, and each section of this review will discuss one method. EEG analyzed following TMS is called TMS-evoked potentials (TEPs). A conditioning TMS can influence the effect of a test TMS given over the motor cortex...
September 5, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28937983/-18f-fdopa-standardized-uptake-values-of-brain-tumors-are-not-exclusively-dependent-on-lat1-expression
#4
Bérengère Dadone-Montaudié, Damien Ambrosetti, Maxime Dufour, Jacques Darcourt, Fabien Almairac, John Coyne, Thierry Virolle, Olivier Humbert, Fanny Burel-Vandenbos
[18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18F]-FDOPA uptake was correlated with level of LAT1 expression in BT. Twenty-eight BT (including 19 gliomas and 9 metastases) were investigated by [18F]-FDOPA-PET prior to surgery and by anti-LAT1 immunohistochemistry on surgical specimens...
2017: PloS One
https://www.readbyqxmd.com/read/28937781/-lymph-node-metastasis-of-merkel-cell-carcinoma-without-known-cutaneous-primary-case-report
#5
Arpád Szabó, Igor Richter, Dana Frydrychová, Martina Saláková, Tomáš Jirásek
Merkel cell carcinoma is a rare cutaneous tumor with an aggressive clinical course. In most cases it is associated with Merkel cell polyomavirus infection. Exceptionally, the tumor can present as a lymph node metastasis without a discernible cutaneous primary. In this report we present the case of a 42 year-old man with inguinal lymphadenopathy, histologically consistent with Merkel cell carcinoma. Tumor cells expressed immunohistochemically chromogranin-A, synaptophysin and displayed dot-like positivity for cytokeratin 20...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28937510/advancements-in-staging-and-imaging-for-penile-cancer
#6
Sarah R Ottenhof, Andrew R Leone, Simon Horenblas, Philippe E Spiess, Erik Vegt
PURPOSE OF REVIEW: We review recent advancements in staging and imaging of penile cancer, including surveillance after therapy. RECENT FINDINGS: For cN0 patients, the sentinel lymph node biopsy is currently considered the preferred way for invasive staging. It has largely replaced other modalities such as staging inguinal lymphadenectomy. Its diagnostic value increases when combined with other staging modalities such as ultrasound with fine-needle aspiration cytology (US-FNAC) or fluorodeoxyglucose-PET with computed tomography (PET/CT)...
September 20, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28937297/clinical-outcome-of-patients-with-early-stage-favorable-hodgkin-lymphoma-treated-with-abvd%C3%A2-%C3%A3-%C3%A2-two-cycles-followed-by-fdg-pet-ct-restaging-and-20%C3%A2-gy-of-involved-site-radiotherapy
#7
Sophia C Kamran, Heather A Jacene, Yu-Hui Chen, Peter M Mauch, Andrea K Ng
Our purpose was to assess outcome of patients with early-stage, favorable (per GHSG criteria) Hodgkin Lymphoma (HL) staged with FDG-PET/CT and treated with two cycles of adriamycin, bleomycin, vincristine, and dacarbazine (ABVD) followed by PET/CT assessment and involved-site radiotherapy (ISRT) to 20 Gy. Records of 23 patients who met eligibility criteria, treated between 2008 and 2016, were reviewed. PET response after two cycles of ABVD was independently assessed by a nuclear medicine physician. After two cycles of ABVD, 91...
September 22, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28937268/real-time-intra-procedural-18f-fdg-pet-ct-guided-biopsy-using-automated-robotic-biopsy-arm-ara-in-the-evaluation-of-thoracic-lesions-with-prior-inconclusive-biopsy-results
#8
Renjith Kalathoorakathu Radhakrishnan, Bhagwant Rai Mittal, Arun Kumar Reddy Gorla, Rajender Kumar Basher, Ashwani Sood, Amanjit Bal, Naveen Kalra, Niranjan Khandelwal, Navneet Singh, Digambar Behera
OBJECTIVE: The aim of this study was to assess the feasibility and appraise the diagnostic utility of real time 18F-FDG PET/CT guided biopsy under automated robotic biopsy arm (ARA) guidance for the evaluation of thoracic lesions with prior inconclusive biopsy results. METHODS: PET/CT guided biopsy of thoracic lesions was performed in patients who had at least one previous inconclusive biopsy. A total of 25 patients (Male: Female- 18 males, 7 females; Age: Range- 13-75; mean- 53...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936941/-diagnostics-in-memory-loss-for-whom-what-and-when
#9
E Richard, E P Moll van Charante
With the advancement of diagnostic tests, the call for an ever-earlier diagnosis of people with memory problems is becoming louder. Diagnostic tests for people with mild cognitive impairment are in fact prognostic tests, complicating the application and interpretation of test results. There is currently insufficient evidence on the incremental diagnostic (or prognostic) value of specific diagnostic tests including MRI, CSF and PET scanning in representative memory clinic populations. Labelling large groups of people who may never develop dementia as having prodromal Alzheimer's disease may be more harmful than a postponed nosological diagnosis in those with mild cognitive impairment...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28936601/texture-analysis-of-high-resolution-dedicated-breast-18-f-fdg-pet-images-correlates-with-immunohistochemical-factors-and-subtype-of-breast-cancer
#10
Alexis Moscoso, Álvaro Ruibal, Inés Domínguez-Prado, Anxo Fernández-Ferreiro, Míchel Herranz, Luis Albaina, Sonia Argibay, Jesús Silva-Rodríguez, Juan Pardo-Montero, Pablo Aguiar
PURPOSE: This study aims to determine whether PET textural features measured with a new dedicated breast PET scanner reflect biological characteristics of breast tumors. METHODS: One hundred and thirty-nine breast tumors from 127 consecutive patients were included in this analysis. All of them underwent a (18)F-FDG PET scan before treatment. Well-known PET quantitative parameters such as SUV m a x , SUV m e a n , metabolically active tumor volume (MATV) and total lesion glycolysis (TLG) were extracted...
September 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28936429/clinical-pet-mri-in-neurooncology-opportunities-and-challenges-from-a-single-institution-perspective
#11
REVIEW
Lisbeth Marner, Otto M Henriksen, Michael Lundemann, Vibeke Andrée Larsen, Ian Law
PURPOSE: Magnetic resonance imaging (MRI) plays a key role in neurooncology, i.e., for diagnosis, treatment evaluation and detection of recurrence. However, standard MRI cannot always separate malignant tissue from other pathologies or treatment-induced changes. Advanced MRI techniques such as diffusion-weighted imaging, perfusion imaging and spectroscopy show promising results in discriminating malignant from benign lesions. Further, supplemental imaging with amino acid positron emission tomography (PET) has been shown to increase accuracy significantly and is used routinely at an increasing number of sites...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28936404/-18-f-fdg-pet-for-assessing-biological-viability-and-prognosis-in-liver-transplant-patients-with-hepatocellular-carcinoma
#12
REVIEW
Arno Kornberg, Martina Schernhammer, Helmut Friess
Liver transplantation (LT) has become standard of care in patients with non-resectable early stage hepatocellular carcinoma (HCC) in liver cirrhosis. Currently, patient selection for LT is strictly based on tumor size and number, provided by the Milan criteria. This may, however, exclude patients with advanced tumor load but favourable biology from a possibly curative treatment option. It became clear in recent years that biological tumor viability rather than tumor macromorphology determines posttransplant outcome...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28935898/pd-l1-is-an-activation-independent-marker-of-brown-adipocytes
#13
Jessica R Ingram, Michael Dougan, Mohammad Rashidian, Marko Knoll, Edmund J Keliher, Sarah Garrett, Scott Garforth, Olga S Blomberg, Camilo Espinosa, Atul Bhan, Steven C Almo, Ralph Weissleder, Harvey Lodish, Stephanie K Dougan, Hidde L Ploegh
Programmed death ligand 1 (PD-L1) is expressed on a number of immune and cancer cells, where it can downregulate antitumor immune responses. Its expression has been linked to metabolic changes in these cells. Here we develop a radiolabeled camelid single-domain antibody (anti-PD-L1 VHH) to track PD-L1 expression by immuno-positron emission tomography (PET). PET-CT imaging shows a robust and specific PD-L1 signal in brown adipose tissue (BAT). We confirm expression of PD-L1 on brown adipocytes and demonstrate that signal intensity does not change in response to cold exposure or β-adrenergic activation...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935840/test-retest-reliability-of-the-sert-imaging-agent-11-c-homadam-in-healthy-humans
#14
Vikram Adhikarla, Boadie W Dunlop, Nachwa Jarkas, Mark Goodman, Helen Mayberg, Michael J Owens, Jonathon A Nye
The aim of this study was to measure the test-retest reliability of (11)C-N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine ([(11)C]HOMADAM) imaging of serotonin transporter (SERT) density in healthy control subjects. Methods: Two female and two male volunteers participated in the study and underwent three [(11)C]HOMADAM Positron Emission Tomography (PET) scans each of 90 min in duration. Time-activity curves were derived from SERT rich structures and fit to two models: 1) a simplified reference tissue model (SRTM) and 2) a multi-linear graphical model (MRTM)...
September 21, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28935838/decreased-pretreatment-amygdalae-serotonin-transporter-binding-in-unipolar-depression-remitters-a-prospective-pet-study
#15
Mala Ananth, Christine DeLorenzo, Jie Yang, J John Mann, Ramin Parsey
Major Depressive Disorder (MDD) is a debilitating condition that affects over 14 million Americans. Remission only occurs in a minority of individuals following first-line antidepressant treatment (~35%); predictors of treatment outcome are therefore needed. Using Positron Emission Tomography (PET) imaging with a radiotracer specific for the serotonin transporter (5-HTT), (11)C-McN5652, we found that patients with MDD who did not achieve remission following 12 months of naturalistic treatment had lower pre-treatment midbrain and amygdala binding compared to healthy volunteers...
September 21, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28935835/total-body-pet-maximizing-sensitivity-to-create-new-opportunities-for-clinical-research-and-patient-care
#16
Simon R Cherry, Terry Jones, Joel S Karp, Jinyi Qi, William Moses, Ramsey Badawi
Positron emission tomography (PET) is widely considered as the most sensitive technique available for non-invasively studying physiology, metabolism and molecular pathways in the living human being. However, the utility of PET, being a photon deficient modality, remains constrained by factors including low signal-to-noise ratio (SNR), long imaging times and concerns regarding radiation dose. Two developments offer the potential to dramatically increase the effective sensitivity of PET. First by increasing the geometric coverage to encompass the entire body, sensitivity can be increased by a factor of ~40 for total-body imaging or a factor of ~4-5 for imaging a single organ such as the brain or heart...
September 21, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28935373/human-alpha-a-crystallin-missing-n-terminal-domain-poorly-complexes-with-filensin-and-phakinin
#17
Jose M Chaves, Ratna Gupta, Kiran Srivastava, Om Srivastava
The aim of this study was to determine relative importance of N-terminal domain and C-terminal extension of αA-crystallin during their in vitro complex formation with phakinin and filensin (the two lens-specific intermediate filament [IF] proteins). Cloned phakinin, filensin and vimentin were purified under a denaturing conditions by consecutive DEAE-cellulose-, hydroxyapatite- and Sephadex G-75-column chromatographic methods. WTαA-crystallin, αA-NT (N-terminal domain [residue number 1-63])-deleted and αA-CT (C-terminal terminal extension [residue number 140-173]-deleted), were cloned in pET 100 TOPO vector, expressed in BL-21 (DE3) cells using 1% IPTG, and purified using a Ni(2+)-affinity column...
September 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28935243/fdg-pet-mr-imaging-in-alveolar-echinococcosis
#18
Felix Lötsch, Fredrik Waneck, Herbert Auer, Klaus Kaczirek, Georgios Karanikas, Michael Ramharter
No abstract text is available yet for this article.
September 18, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28934923/discriminative-sparse-features-for-alzheimer-s-disease-diagnosis-using-multimodal-image-data
#19
A Ortiz, F Lozano, J M Gorriz, J Ramírez, F J Martinez-Murci, For The Alzheimer S Disease Neuroimaging Initiative
BACKGROUND: Feature extraction in medical image processing still remains a challenge, especially in high-dimensionality datasets, where the expected number of available samples is considerably lower than the dimension of the feature space. This is a common problem in real-world data, and, specifically, in medical image pro- cessing as, while images are composed of hundreds of thousands voxels, only a reduced number of patients are available. OBJECTIVE: Extracting descriptive and discriminative features to represent each sample (image) by a small number of features, which is particularly important in classification task, due to the curse of dimensionality problem...
September 21, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28934254/deep-reconstruction-model-for-dynamic-pet-images
#20
Jianan Cui, Xin Liu, Yile Wang, Huafeng Liu
Accurate and robust tomographic reconstruction from dynamic positron emission tomography (PET) acquired data is a difficult problem. Conventional methods, such as the maximum likelihood expectation maximization (MLEM) algorithm for reconstructing the activity distribution-based on individual frames, may lead to inaccurate results due to the checkerboard effect and limitation of photon counts. In this paper, we propose a stacked sparse auto-encoder based reconstruction framework for dynamic PET imaging. The dynamic reconstruction problem is formulated in a deep learning representation, where the encoding layers extract the prototype features, such as edges, so that, in the decoding layers, the reconstructed results are obtained through a combination of those features...
2017: PloS One
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