Kastriot Kastrati, Thomas S Nakuz, Oana C Kulterer, Irina Geßl, Elisabeth Simader, Daniel Mrak, Michael Bonelli, Hans Peter Kiener, Florian Prayer, Helmut Prosch, Daniel Aletaha, Werner Langsteger, Tatjana Traub-Weidinger, Stephan Blüml, Helga Lechner-Radner, Marcus Hacker, Peter Mandl
BACKGROUND: Interstitial lung disease (ILD) is a common manifestation of idiopathic inflammatory myopathies (IIM) and a substantial contributor to hospitalisation, increased morbidity, and mortality. In-vivo evidence of ongoing tissue remodelling in IIM-ILD is scarce. We aimed to evaluate fibroblast activation in lungs of IIM-patients and control individuals using ⁶⁸Ga-labelled inhibitor of Fibroblast-Activation-Protein (FAPi) based positronic emission tomography and computed tomography imaging (PET/CT)...
June 2024: EClinicalMedicine