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https://www.readbyqxmd.com/read/28646744/systematic-biobanking-novel-imaging-techniques-and-advanced-molecular-analysis-for-precise-tumor-diagnosis-and-therapy-the-polish-mobit-project
#1
Jacek Niklinski, Adam Kretowski, Marcin Moniuszko, Joanna Reszec, Anna Michalska-Falkowska, Magdalena Niemira, Michal Ciborowski, Radoslaw Charkiewicz, Dorota Jurgilewicz, Miroslaw Kozlowski, Rodryg Ramlau, Cezary Piwkowski, Miroslaw Kwasniewski, Monika Kaczmarek, Andrzej Ciereszko, Tomasz Wasniewski, Robert Mroz, Wojciech Naumnik, Ewa Sierko, Magdalena Paczkowska, Joanna Kisluk, Anetta Sulewska, Adam Cybulski, Zenon Mariak, Boguslaw Kedra, Jacek Szamatowicz, Paweł Kurzawa, Lukasz Minarowski, Angelika Edyta Charkiewicz, Barbara Mroczko, Jolanta Malyszko, Christian Manegold, Lothar Pilz, Heike Allgayer, Mohammed L Abba, Hartmut Juhl, Frauke Koch
Personalized and precision medicine is gaining recognition due to the limitations by standard diagnosis and treatment; many areas of medicine, from cancer to psychiatry, are moving towards tailored and individualized treatment for patients based on their clinical characteristics and genetic signatures as well as novel imaging techniques. Advances in whole genome sequencing have led to identification of genes involved in a variety of diseases. Moreover, biomarkers indicating severity of disease or susceptibility to treatment are increasingly being characterized...
June 21, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28646687/cortical-amyloid-accumulation-is-associated-with-alterations-of-structural-integrity-in-older-people-with-subjective-memory-complaints
#2
Stefan J Teipel, Enrica Cavedo, Sarah Weschke, Michel J Grothe, Katrine Rojkova, Gaëlle Fontaine, Luce Dauphinot, Gabriel Gonzalez-Escamilla, Marie-Claude Potier, Hugo Bertin, Marie-Odile Habert, Bruno Dubois, Harald Hampel
We determined the effect of cortical amyloid load using (18)F-florbetapir PET on cognitive performance and gray matter structural integrity derived from MRI in 318 cognitively normally performing older people with subjective memory impairment from the INSIGHT-preAD cohort using multivariate partial least squares regression. Amyloid uptake was associated with reduced gray matter structural integrity in hippocampus, entorhinal and cingulate cortex, middle temporal gyrus, prefrontal cortex, and lentiform nucleus (p < 0...
May 31, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28646645/comorbidity-assessment-in-patients-with-oral-squamous-cell-carcinoma-can-imaging-techniques-fludeoxyglucose-positron-emission-tomographic-computed-tomography-and-contrast-enhanced-computed-tomography-provide-additional-information
#3
Matthias Troeltzsch, Florian Andreas Probst, Axel Rominger, Ulrich Müller-Lisse, Monika Probst, Katharina Obermeier, Michael Ehrenfeld, Sven Otto
PURPOSE: This study evaluated the role of imaging staging examinations (positron-emission tomographic computed tomography [PET/CT] and contrast-enhanced computed tomography [ceCT]) for the assessment of the comorbidity status of patients with oral squamous cell carcinoma (OSCC). A binary null hypothesis was drafted: 1) imaging staging examinations do not augment knowledge about the comorbidity status of patients with OSCC and 2) there is no difference between PET/CT and ceCT in this regard...
May 31, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28646614/does-breast-mri-background-parenchymal-enhancement-indicate-metabolic-activity-qualitative-and-3d-quantitative-computer-imaging-analysis
#4
Eralda Mema, Victoria L Mango, Xiaotao Guo, Jenika Karcich, Randy Yeh, Ralph T Wynn, Binsheng Zhao, Richard S Ha
PURPOSE: To investigate whether the degree of breast magnetic resonance imaging (MRI) background parenchymal enhancement (BPE) is associated with the amount of breast metabolic activity measured by breast parenchymal uptake (BPU) of 18F-FDG on positron emission tomography / computed tomography (PET/CT). MATERIALS AND METHODS: An Institutional Review Board (IRB)-approved retrospective study was performed. Of 327 patients who underwent preoperative breast MRI from 1/1/12 to 12/31/15, 73 patients had 18F-FDG PET/CT evaluation performed within 1 week of breast MRI and no suspicious findings in the contralateral breast...
June 24, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28646594/prevalence-and-prognosis-of-low-volume-oligorecurrent-hormone-sensitive-prostate-cancer-amenable-to-lesion-ablative-therapy
#5
Aurélie De Bruycker, Bieke Lambert, Tom Claeys, Louke Delrue, Chamberlain Mbah, Gert De Meerleer, Geert Villeirs, Filip De Vos, Kathia De Man, Karel Decaestecker, Valérie Fonteyne, Nicolaas Lumen, Filip Ameye, Ignace Billiet, Steven Joniau, Friedl Vanhaverbeke, Wim Duthoy, Piet Ost
OBJECTIVES: To describe the anatomical patterns of PCa recurrence following primary therapy and investigate if patients with low-volume disease have a better prognosis as compared to their counterparts. MATERIAL AND METHODS: Patients eligible for a F18-choline PET-CT were entered in a prospective cohort study. Eligible patients had an asymptomatic biochemical recurrence following primary PCa treatment and testosterone levels >50 ng/ml. The number of lesions were counted per scan...
June 24, 2017: BJU International
https://www.readbyqxmd.com/read/28646593/mri-assisted-dual-motion-correction-for-myocardial-perfusion-defect-detection-in-pet-imaging
#6
Xinhui Wang, Arman Rahmim, Jing Tang
PURPOSE: Myocardial perfusion (MP) PET imaging is a powerful tool in risk assess-assessment and stratification of patients with coronary artery disease. Involuntary organmotion degrades cardiac PET image resolution while respiratory and/or cardiac gating to freeze the motion leads to noisier reconstructed images due to reduced counts in the gated frames. In this work, we propose an MRI assisted dual motion correction method to compensate for respiratory and cardiac motion in MP PET data and study the impact of dual motion correction on MP defect detection using systematically designed experiments...
June 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28646463/patterns-of-failure-after-radical-prostatectomy-in-prostate-cancer-implications-for-radiation-therapy-planning-after-68-ga-psma-pet-imaging
#7
Kilian Schiller, K Sauter, S Dewes, M Eiber, T Maurer, J Gschwend, S E Combs, G Habl
BACKGROUND: Salvage radiotherapy (SRT) after radical prostatectomy (RPE) and lymphadenectomy (LAE) is the appropriate radiotherapy option for patients with persistent/ recurrent prostate cancer (PC). (68)Ga-PSMA-PET imaging has been shown to accurately detect PC lesions in a primary setting as well as for local recurrence or for lymph node (LN) metastases. OBJECTIVE: In this study we evaluated the patterns of recurrence after RPE in patients with PC, putting a highlight on the differentiation between sites that would have been covered by a standard radiation therapy (RT) field in consensus after the RTOG consensus and others that would have not...
June 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28646462/diagnostic-utility-of-pet-ct-with-18-f-dopa-and-18-f-fdg-in-persistent-or-recurrent-medullary-thyroid-carcinoma-the-importance-of-calcitonin-and-carcinoembryonic-antigen-cutoff
#8
Ana Reyes Romero-Lluch, Juan Ignacio Cuenca-Cuenca, Raquel Guerrero-Vázquez, Antonio Jesús Martínez-Ortega, Juan Luis Tirado-Hospital, Isabel Borrego-Dorado, Elena Navarro-González
PURPOSE: This study sought to evaluate and compare the utility of 18-F-fluorodihydroxyphenylalanine ((18)F-DOPA) and 18-F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for identification of lesions in patients with recurrent medullary thyroid carcinoma (MTC). In addition, we analyzed the correlation between the calcitonin (Ct), carcinoembryonic antigen (CEA) levels, each doubling time (DT), and PET positivity. We evaluated the reliability of the 150 pg/mL Ct cutoff set by the American Thyroid Association guidelines for further imaging (including (18)F-DOPA PET/CT)...
June 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28646331/textural-features-of-18-f-fdg-pet-after-two-cycles-of-neoadjuvant-chemotherapy-can-predict-pcr-in-patients-with-locally-advanced-breast-cancer
#9
Lin Cheng, Jianping Zhang, Yujie Wang, Xiaoli Xu, Yongping Zhang, Yingjian Zhang, Guangyu Liu, Jingyi Cheng
OBJECTIVE: This study was designed to evaluate the utility of textural features for predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). METHODS: Sixty-one consecutive patients with locally advanced breast cancer underwent (18)F-FDG PET/CT scanning at baseline and after the second course of NAC. Changes to imaging parameters [maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG)] and textural features (entropy, coarseness, skewness) between the 2 scans were measured by two independent radiologists...
June 23, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28646088/closing-the-brief-case-a-fishy-tale-prevents-digital-doom-following-polly-s-peck-the-importance-of-pets-in-a-comprehensive-medical-history
#10
EDITORIAL
P A Simpson, M Przybylo, T J Blanchard, T Wingfield
No abstract text is available yet for this article.
July 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28646087/the-brief-case-a-fishy-tale-prevents-digital-doom-following-polly-s-peck-the-importance-of-pets-in-a-comprehensive-medical-history
#11
EDITORIAL
P A Simpson, M Przybylo, T J Blanchard, T Wingfield
No abstract text is available yet for this article.
July 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28646014/the-impact-of-68-ga-psma-pet-ct-on-management-intent-in-prostate-cancer-results-of-an-australian-prospective-multicenter-study
#12
Paul J Roach, Roslyn Francis, Louise Emmett, Edward Hsiao, Andrew Kneebone, George Hruby, Thomas Eade, Quoc Nguyen, Ben Thompson, Tom Cusick, Michael McCarthy, Colin Tang, Bao Ho, Philip Stricker, Andrew Scott
(68)Ga-PSMA PET/CT scanning has been shown to be more sensitive than conventional imaging techniques in patients with prostate cancer. This prospective Australian multicenter study assessed whether (68)Ga-PSMA PET/CT imaging impacts on management intent in patients with primary or recurrent prostate cancer. Methods: Prior to undertaking (68)Ga-PSMA PET imaging, referring medical specialists completed a questionnaire detailing relevant demographic and clinical data as well as their proposed management plan. A separate follow up questionnaire was completed after the (68)Ga-PSMA PET/CT scan results were available to determine whether their management plan would change...
June 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28646013/doxorubicin-effect-on-myocardial-metabolism-as-a-pre-requisite-for-subsequent-development-of-cardiac-toxicity-a-translational-18-f-fdg-pet-ct-observation
#13
Matteo Bauckneht, Giulia Ferrarazzo, Francesco Fiz, Silvia Morbelli, Matteo Sarocchi, Fabio Pastorino, Alberto Ghidella, Elena Pomposelli, Maurizio Miglino, Pietro Ameri, Laura Emionite, Flavia Ticconi, Eleonora Arboscello, Ambra Buschiazzo, Elena Augusta Massimelli, Salvatore Fiordoro, Anna Borra, Vanessa Cossu, Annalisa Bozzano, Adalberto Ibatici, Mirco Ponzoni, Paolo Spallarossa, Andrea Gallamini, Paolo Bruzzi, Gianmario Sambuceti, Cecilia Marini
The present translational study aimed to verify whether serial (18)F-fluoro-deoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT), predicts doxorubicin cardiotoxicity. Methods: Fifteen athymic mice were treated with intravenous administration of saline (n = 5), doxorubicin 5 mg/Kg (n = 5) or doxorubicin 7.5 mg/Kg (n = 5) and submitted to dynamic microPET scan to estimate left ventricular glucose consumption (LV-MRGlu) before and after chemotherapy. Thereafter, we retrospectively identified 69 patients successfully treated with Adriamycin, Bleomycin, Vinblastine, and Dacarbazine (ABVD) regimen for Hodgkin's Disease (HD) and submitted to four consecutive FDG-PET/CT scans...
June 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28646012/scatter-correction-with-combined-single-scatter-simulation-and-monte-carlo-simulation-scaling-improved-the-visual-artifacts-and-quantification-in-3d-brain-pet-ct-imaging-with-15-o-gas-inhalation
#14
Keiichi Magota, Tohru Shiga, Yukari Asano, Daiki Shinyama, Jinghan Ye, Amy E Perkins, Piotr J Maniawski, Takuya Toyonaga, Kentaro Kobayashi, Kenji Hirata, Chietsugu Katoh, Naoya Hattori, Nagara Tamaki
In three-dimensional positron emission tomography (PET)/computed tomography (CT) imaging of the brain with (15)O-gas inhalation, high radioactivity in the face mask creates cold artifacts and affects the quantitative accuracy when scatters is corrected by conventional methods (e.g., single-scatter simulation [SSS] with tail-fitting scaling [TFS-SSS]). Here we examined the validity of a newly developed scatter correction method that combines SSS with a scaling factor calculated by Monte Carlo simulation (MCS-SSS)...
June 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28645685/concordance-between-brain-18-f-fdg-pet-and-cerebrospinal-fluid-biomarkers-in-diagnosing-alzheimer-s-disease
#15
S Rubí, A Noguera, S Tarongí, M Oporto, A García, H Vico, A Espino, M J Picado, A Mas, C Peña, G Amer
OBJECTIVES: Cortical posterior hypometabolism on PET imaging with (18)F-FDG (FDG-PET), and altered levels of Aß1-42 peptide, total Tau (tTau) and phosphorylated Tau (pTau) proteins in cerebrospinal fluid (CSF) are established diagnostic biomarkers in Alzheimer's disease (AD). An evaluation has been made of the concordance and relationship between the results of FDG-PET and CSF biomarkers in symptomatic patients with suspected AD. MATERIAL AND METHODS: A retrospective review was carried out on 120 patients with cognitive impairment referred to our Cognitive Neurology Unit, and who were evaluated by brain FDG-PET and a lumbar puncture for CSF biomarkers...
June 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28645683/a-single-brain-metastasis-seen-on-68-ga-psma-pet-ct-in-recurrent-of-breast-cancer
#16
S S Medina-Ornelas, F O García-Pérez, C Medel-Gamez, E Paredes-Amoroto
No abstract text is available yet for this article.
June 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28645205/aquaporin-positron-emission-tomography-differentiates-between-grade-iii-and-iv-human-astrocytoma
#17
Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Satoshi Kurabe, Kouichirou Okamoto, Hiroshi Aoki, Hiroki Kitaura, Akiyoshi Kakita, Yukihiko Fujii, Vincent J Huber, Hironaka Igarashi, Ingrid L Kwee, Tsutomu Nakada
BACKGROUND: Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade. OBJECTIVE: To examine the utility of aquaporin positron emission tomography (PET) for differentiating between astrocytoma grade III and grade IV using the AQP radioligand [ 11 C]TGN-020...
June 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28645096/incidental-focal-uptake-in-the-breast-and-axilla-on-fdg-pet-clinical-considerations-and-differential-diagnosis
#18
Andrea L Magee, Brittany Z Dashevsky, Kayleen Jahangir, Kirti Kulkarni
Incidental focal FDG uptake in the breast or axilla on PET/CT performed for evaluation of extra-mammary primary disease presents a diagnostic challenge. Radiologists must consider a broad differential diagnosis, assess clinical history, and judiciously employ other imaging modalities such as mammography, ultrasound and MRI in the pursuit of findings which help narrow the differential diagnosis. Tissue sampling may be reserved for nondiagnostic imaging scenarios.
June 15, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28644875/estimation-of-the-optimal-dosing-regimen-of-escitalopram-in-dogs-a-dose-occupancy-study-with-11c-dasb
#19
Olivia Taylor, Nick Van Laeken, Ingeborgh Polis, Robrecht Dockx, Lise Vlerick, Andre Dobbeleir, Ingeborg Goethals, Jimmy Saunders, Nele Sadones, Chris Baeken, Filip De Vos, Kathelijne Peremans
Although the favourable characteristics of escitalopram as being the most selective serotonin reuptake inhibitor and having an increased therapeutic efficacy via binding on an additional allosteric binding site of the serotonin transporter, its dosing regimen has not yet been optimized for its use in dogs. This study aimed to estimate the optimal dosing frequency and the required dose for achieving 80% occupancy of the serotonin transporters in the basal ganglia. The dosing frequency was investigated by determining the elimination half-life after a four day oral pre-treatment period with 0...
2017: PloS One
https://www.readbyqxmd.com/read/28644848/exploring-the-differences-between-pet-and-non-pet-owners-implications-for-human-animal-interaction-research-and-policy
#20
Jessica Saunders, Layla Parast, Susan H Babey, Jeremy V Miles
There is conflicting evidence about whether living with pets results in better mental and physical health outcomes, with the majority of the empirical research evidence being inconclusive due to methodological limitations. We briefly review the research evidence, including the hypothesized mechanisms through which pet ownership may influence health outcomes. This study examines how pet and non-pet owners differ across a variety of socio-demographic and health measures, which has implications for the proper interpretation of a large number of correlational studies that attempt to draw causal attributions...
2017: PloS One
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