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https://www.readbyqxmd.com/read/29150108/economy-class-syndrome-what-is-it-and-who-are-the-individuals-at-risk
#1
Luci Maria SantAna Dusse, Marcos Vinícius Ferreira Silva, Letícia Gonçalves Freitas, Milena Soriano Marcolino, Maria das Graças Carvalho
The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism...
October 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29141661/preventing-enduring-behavioural-problems-in-young-children-through-early-psychological-intervention-healthy-start-happy-start-study-protocol-for-a-randomized-controlled-trial
#2
Paul G Ramchandani, Christine O'Farrelly, Daphne Babalis, Marian J Bakermans-Kranenburg, Sarah Byford, Ellen S R Grimas, Jane E Iles, Marinus H van IJzendoorn, Julia McGinley, Charlotte M Phillips, Alan Stein, Jane Warwick, Hillary C Watt, Stephen Scott
BACKGROUND: Behavioural problems are common in early childhood, and can result in enduring costs to the individual and society, including an increased risk of mental and physical illness, criminality, educational failure and drug and alcohol misuse. Most previous research has examined the impact of interventions targeting older children when difficulties are more established and harder to change, and have rarely included fathers. We are conducting a trial of a psychological intervention delivered to families with very young children, engaging both parents where possible...
November 15, 2017: Trials
https://www.readbyqxmd.com/read/29122819/treatment-of-conjunctival-melanoma-in-a-dutch-referral-centre
#3
Niels J Brouwer, Marina Marinkovic, Sjoerd G van Duinen, Jaco C Bleeker, Martine J Jager, Gregorius P M Luyten
AIMS: To evaluate the treatment of conjunctival melanoma at a large Dutch referral centre and to make recommendations for clinical management. METHODS: A retrospective review was performed of clinical and histological data of 70 patients treated for a primary conjunctival melanoma between 2001 and 2014 at the Leiden University Medical Center, Leiden, the Netherlands. Detailed follow-up data were available for all patients. RESULTS: The mean follow-up time was 70...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29121499/atorvastatin-accelerates-clearance-of-lipoprotein-remnants-generated-by-activated-brown-fat-to-further-reduce-hypercholesterolemia-and-atherosclerosis
#4
Geerte Hoeke, Yanan Wang, Andrea D van Dam, Isabel M Mol, Eveline Gart, Henk G Klop, Susan M van den Berg, Elsbet H Pieterman, Hans M G Princen, Albert K Groen, Patrick C N Rensen, Jimmy F P Berbée, Mariëtte R Boon
BACKGROUND AND AIMS: Activation of brown adipose tissue (BAT) reduces both hyperlipidemia and atherosclerosis by increasing the uptake of triglyceride-derived fatty acids by BAT, accompanied by formation and clearance of lipoprotein remnants. We tested the hypothesis that the hepatic uptake of lipoprotein remnants generated by BAT activation would be accelerated by concomitant statin treatment, thereby further reducing hypercholesterolemia and atherosclerosis. METHODS: APOE*3-Leiden...
October 26, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29120005/peripheral-neuropathy-due-to-recreational-use-of-nitrous-oxide-presenting-after-an-ankle-sprain-with-foot-drop
#5
Jackson A Middleton, John A Roffers
A 22-year-old man was referred for orthopedic follow-up after an ankle injury. Initial evaluation in urgent care included radiographs with negative findings. After a delayed presentation, a course of functional treatment was recommended. Subsequently, he developed a deep venous thrombosis and pulmonary emboli. He was found to be factor V Leiden deficient and was fully anticoagulated on warfarin. Later reevaluation revealed a steppage gait and foot drop. Electrodiagnostic studies (ie, electromyography and nerve conduction studies) revealed a severe peripheral polyneuropathy...
November 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/29109836/pedicle-flaps-contribute-to-endoscopic-skull-base-surgery-and-facial-soft-tissue-repair-the-diuturnity-of-johannes-fredericus-samuel-esser-1877-1946
#6
Richard A Pollock, M Douglas Gossman
Pedicle flaps based on the external maxillary (facial) artery were introduced during the World War I, precisely a century ago. Today they remain effective tools in facial soft-tissue repair. Recently, pedicle flaps based on the internal maxillary (sphenopalatine) artery have been chosen to reliably close dural defects after endoscopic skull-base surgery. Pedicle flaps, "biologic" to the extent they are based on a defined arterial blood supply, are the lasting contributions-the diuturnity-of Johannes ("Jan") Fredericus Samuel Esser (1877-1946) of Leiden, Holland, and Chicago (IL)...
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29106324/safety-of-specific-immunotherapy-using-an-ultra-rush-induction-regimen-in-bee-and-wasp-allergy
#7
Andrzej Bożek, Krzysztof Kołodziejczyk
BACKGROUND: Specific allergen immunotherapy to Hymenoptera venom (VIT) is a basic treatment for patients allergic to Hymenoptera venom. The aim of the study was to evaluate the safety of an ultra-rush regimen compared with the rush and conventional protocols. MATERIALS AND METHODS: In 31 patients with an allergy to bee venom and 82 with an allergy to wasp venom, the allergic adverse reactions during VIT were monitored. Patients were selected based on the criteria established by EAACI (European Academy of Allergy and Clinical Immunology) recommendations...
November 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29102674/protective-effects-of-biodegradable-collagen-implants-on-thinned-sclera-after-strabismus-surgery-a-paired-eye-study
#8
Tae Keun Yoo, Sueng-Han Han, Jinu Han
PURPOSE: To determine the efficacy of a biodegradable Ologen (Aeon Astron Europe BV, Leiden, The Netherlands) collagen matrix in reducing the blue color change due to exposed thinned sclera after strabismus surgery. METHODS: Fourteen patients with intermittent exotropia undergoing symmetric bilateral lateral rectus recession surgery were included in this prospective, randomized, paired-eye controlled study. In each patient, Ologen was implanted at the original rectus insertion site in one randomly selected eye; the other eye underwent conventional surgery...
November 1, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29102596/assessment-of-novel-cardiovascular-biomarkers-in-women-with-a-history-of-recurrent-miscarriage
#9
M M Wagner, J W Jukema, W Hermes, S le Cessie, C J M de Groot, J A Bakker, J M M van Lith, K W M Bloemenkamp
OBJECTIVES: A history of recurrent miscarriage is associated with future cardiovascular disease. The aim of this study was to determine novel cardiovascular biomarkers in women with a history of recurrent miscarriage as this might lead to a better understanding of the association. STUDY DESIGN: Women who visited the recurrent miscarriage clinic at Leiden University Medical Centre (between 2000 and 2010), and had three consecutive miscarriages ≤30 years were invited to participate in this follow-up study (between 2012 and 2014)...
October 28, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29097267/spontaneous-neonatal-renal-vein-thromboses-should-we-treat-them-all-a-report-of-five-cases-and-a-literature-review
#10
François Niada, René Tabin, Simon Kayemba-Kay's
Renal vein thrombosis (RVT) is a rare but well-known neonatal entity for which several therapeutic modalities are reported in the literature because of the lack of consensus management guidelines. POPULATION AND METHODS: A retrospective study of the medical records of children managed between January 1990 and December 2013, and whose final diagnosis was RVT. The diagnosis was initially clinical and subsequently confirmed by the abdominal ultrasonography (AUS) and Doppler imaging if necessary...
October 9, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29095566/predictive-testing-of-minors-for-huntington-s-disease-the-uk-and-netherlands-experiences
#11
Oliver W Quarrell, Angus J Clarke, Cecilia Compton, Christine E M de Die-Smulders, Alan Fryer, Sian Jenkins, Nayana Lahiri, Rhona MacLeod, Zosia Miedzybrodzka, Patrick J Morrison, Hannah Musgrave, Mary O'Driscoll, Mark Strong, Martine J van Belzen, Sascha Vermeer, Corien C Verschuuren-Bemelmans, Emilia K Bijlsma
A consistent feature of predictive testing guidelines for Huntington's disease (HD) is the recommendation not to undertake predictive tests on those < 18 years. Exceptions are made but the extent of, and reasons for, deviation from the guidelines are unknown. The UK Huntington's Prediction Consortium has collected data annually on predictive tests undertaken from the 23 UK genetic centers. DNA analysis for HD in the Netherlands is centralized in the Laboratory for Diagnostic Genome Analysis in Leiden. In the UK, 60 tests were performed on minors between 1994 and 2015 representing 0...
November 2, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29094466/joint-effects-of-prothrombotic-genotypes-and-body-height-on-the-risk-of-venous-thromboembolism-the-troms%C3%A3-study
#12
Lars D Horvei, Sigrid K Braekkan, Erin N Smith, Terry Solomon, Kristian Hindberg, Kelly A Frazer, Frits R Rosendaal, John-Bjarne Hansen
BACKGROUND: Studies have reported synergistic effects of prothrombotic single nucleotide polymorphisms (SNPs) and obesity on the risk of venous thromboembolism (VTE). Tall stature is associated with increased VTE risk, but the joint effect of prothrombotic genotypes and tall stature on VTE risk is unknown. AIMS: To investigate the joint effects of prothrombotic genotypes and tall stature on the risk of VTE. METHODS: Cases with incident VTE (n=676) and a randomly selected age-weighted subcohort (n=1842) were sampled from the Tromsø study (cohort follow-up: 1994-2012)...
November 2, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29093997/inferring-microevolution-from-museum-collections-and-resampling-lessons-learned-from-cepaea
#13
Małgorzata Ożgo, Thor-Seng Liew, Nicole B Webster, Menno Schilthuizen
Natural history collections are an important and largely untapped source of long-term data on evolutionary changes in wild populations. Here, we utilize three large geo-referenced sets of samples of the common European land-snail Cepaea nemoralis stored in the collection of Naturalis Biodiversity Center in Leiden, the Netherlands. Resampling of these populations allowed us to gain insight into changes occurring over 95, 69, and 50 years. Cepaea nemoralis is polymorphic for the colour and banding of the shell; the mode of inheritance of these patterns is known, and the polymorphism is under both thermal and predatory selection...
2017: PeerJ
https://www.readbyqxmd.com/read/29093435/recurrent-thrombosis-a-case-of-hereditary-thromboembolism
#14
Maria Concetta Giofrè, Francesca Napoli, Daniela La Rosa, Alessia Caruso, Natascia Laganà, Lucia Orlando Settembrini, Antonino Saitta, Antonio Giovanni Versace
BACKGROUND Thrombophilia is a predisposition to thrombosis. Genetic causes include antithrombin III, protein C, protein S, factor V Leiden, prothrombin 20210A allele, and MTHFR mutations. Other genetic factors causing thrombosis and pulmonary embolism have been identified in recent studies, including 4G/4G polymorphism of the PAI-1 gene. CASE REPORT A patient with a personal and family history of recurrent thrombosis and pulmonary embolism was admitted to our Internal Medicine Department. After the most common acquired risk factors for thromboembolism were ruled out, the patient and her family members underwent genetic diagnostic testing...
November 2, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29087287/impact-of-genetic-defects-on-coronary-atherosclerosis-among-turkish-cypriots
#15
Cenk Conkbayir, Rezan Fahrioglu Yamaci, Pinar Gencer, Burc Barin, Genco Yucel, Cenk Eray Yildiz, Murat Ugurlucan, A Nazli Basak
BACKGROUND: The distribution of gene variants in the Turkish Cypriot population with coronary artery disease has not been investigated. In this study, we sought to research different genetic variants in the susceptibility to coronary artery disease and to identify possible associations between various clinical parameters and the genes involved in blood coagulation as well as glucose and lipid metabolism among the Turkish Cypriots and compared the results with the respective Turkish patients from Turkey...
October 30, 2017: Heart Surgery Forum
https://www.readbyqxmd.com/read/29077664/a-case-report-of-recurrent-severe-peripartum-cardiomyopathy-complicated-by-factor-v-leiden-and-multiple-endocrine-neoplasia-type-1-a-management-conundrum
#16
Amanda M Kleiman, Jessica L Sheeran, Mohamed Tiouririne
Cardiovascular disease is the leading cause of peripartum death in the United States during pregnancy. The presence of concomitant diagnoses may complicate or conflict with the management of the primary cardiovascular diagnosis and further complicate pregnancy and delivery. We describe the management of a 29-year-old, gravida 5, para 1 woman with severe peripartum cardiomyopathy during this and a previous pregnancy complicated by multiple endocrine neoplasia type and factor V Leiden thrombophilia, limiting therapeutic options and contributing to considerable perioperative management challenges...
October 26, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29074563/pregnancy-thrombophilia-and-the-risk-of-a-first-venous-thrombosis-systematic-review-and-bayesian-meta-analysis
#17
REVIEW
F Nanne Croles, Kazem Nasserinejad, Johannes J Duvekot, Marieke Jha Kruip, Karina Meijer, Frank Wg Leebeek
Objective To provide evidence to support updated guidelines for the management of pregnant women with hereditary thrombophilia in order to reduce the risk of a first venous thromboembolism (VTE) in pregnancy.Design Systematic review and bayesian meta-analysis.Data sources Embase, Medline, Web of Science, Cochrane Library, and Google Scholar from inception through 14 November 2016.Review methods Observational studies that reported on pregnancies without the use of anticoagulants and the outcome of first VTE for women with thrombophilia were eligible for inclusion...
October 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29074298/variable-cartilage-degradation-in-mice-with-diet-induced-metabolic-dysfunction-food-for-thought
#18
A E Kozijn, L M Gierman, F van der Ham, P Mulder, M C Morrison, S Kühnast, R A van der Heijden, M P Stavro, A van Koppen, E J Pieterman, A M van den Hoek, R Kleemann, H M G Princen, S C Mastbergen, F P J G Lafeber, A-M Zuurmond, I Bobeldijk, H Weinans, R Stoop
OBJECTIVE: Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was established by various dietary approaches. DESIGN: Wild-type C57BL/6J mice and genetically modified mice (hCRP, LDLr(-/-). Leiden and ApoE*3Leiden...
October 24, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29073275/thrombosis-after-liver-transplantation-for-hepatocellular-carcinoma
#19
MULTICENTER STUDY
Ida Martinelli, Francesca R Ponziani, Alberto Maino, Sherrie Bhoori, Maria Abbattista, Umberto Maggi, Tullia M De Feo, Paolo Bucciarelli, Andrea Artoni, Elena Longhi, Marta Serafini, Giorgio Rossi, Vincenzo Mazzaferro
The influence of thrombosis on the prognosis of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT) and the role of the commonest inherited thrombophilia abnormalities factor V Leiden and prothrombin G20210A in the development of thrombosis are unknown. We investigated a cohort of patients who underwent LT for HCC with the aim to estimate the incidence rate (IR) of thrombosis, its influence on mortality and re-transplantation rates and, in the frame of a nested case-control study, the role of thrombophilia in donors and recipients for the development of thrombosis...
2017: PloS One
https://www.readbyqxmd.com/read/29070732/thyroid-status-and-mortality-in-nonagenarians-from-long-lived-families-and-the-general-population
#20
Nicolien A van Vliet, Evie van der Spoel, Marian Beekman, P Eline Slagboom, Gerard Jan Blauw, Jacobijn Gussekloo, Rudi G J Westendorp, Diana van Heemst
The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associations were different in nonagenarians from long-lived families than in nonagenarians from the general population. In total, 805 nonagenarians from the Leiden Longevity Study and 259 nonagenarians from the Leiden 85-plus Study were followed up to collect mortality data...
October 25, 2017: Aging
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