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https://www.readbyqxmd.com/read/28627093/characterization-of-thrombosis-in-patients-with-proteus-syndrome
#1
Kim M Keppler-Noreuil, Jay N Lozier, Julie C Sapp, Leslie G Biesecker
Patients with overgrowth and complex vascular malformation syndromes, including Proteus syndrome have an increased risk of thromboembolism. Proteus syndrome is a mosaic, progressive overgrowth disorder involving vasculature, skin, and skeleton, and caused by a somatic activating mutation in AKT1. We conducted a comprehensive review of the medical histories and hematologic evaluations of 57 patients with Proteus syndrome to identify potential risk factors for thrombosis. We found that six of ten patients, who were deceased, died secondary to deep venous thrombosis and/or pulmonary embolism...
June 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28622045/age-related-characteristics-of-outpatients-with-anxiety-disorders-the-leiden-routine-outcome-monitoring-study
#2
Anke Schat, Martijn S van Noorden, Therese van Amelsvoort, Erik J Giltay, Nic J A van der Wee, Marc J Noom, Robert R J M Vermeiren, Frans G Zitman
OBJECTIVE: It has been hypothesised that clinically important age-related differences between adults with anxiety disorders exist; this study aims to elucidate these differences. METHODS: We analysed data from 1950 outpatients diagnosed with DSM-IV-TR anxiety disorders treated at a Dutch hospital or affiliated mental healthcare centres. Three age-groups (young- (18-25; n = 435), mid- (26-40; n = 788) and older adult (41-65; n = 727)) were compared with regard to social demographic characteristics, diagnostic characteristics, anxiety symptom profile, general psychiatric symptom profile and generic health status, in addition, linear analyses were carried out with age as a continuous variable...
June 16, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28608013/quality-of-recovery-after-low-pressure-laparoscopic-donor-nephrectomy-facilitated-by-deep-neuromuscular-blockade-a-randomized-controlled-study
#3
Denise M D Özdemir-van Brunschot, Gert J Scheffer, Michel van der Jagt, Hans Langenhuijsen, Albert Dahan, Janneke E E A Mulder, Simone Willems, Luuk B Hilbrands, Rogier Donders, Cees J H M van Laarhoven, Frank A d'Ancona, Michiel C Warlé
BACKGROUND: The use of low intra-abdominal pressure (<10 mmHg) reduces postoperative pain scores after laparoscopic surgery. OBJECTIVE: To investigate whether low-pressure pneumoperitoneum with deep neuromuscular blockade improves the quality of recovery after laparoscopic donor nephrectomy (LDN). DESIGN, SETTING AND PARTICIPANTS: In a single-center randomized controlled trial, 64 live kidney donors were randomly assigned to 6 or 12 mmHg insufflation pressure...
June 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28606964/differences-in-the-symptomatic-phase-preceding-acpa-positive-and-acpa-negative-ra-a-longitudinal-study-in-arthralgia-during-progression-to-clinical-arthritis
#4
Leonie E Burgers, Hanna W van Steenbergen, Robin M Ten Brinck, Tom Wj Huizinga, Annette Hm van der Helm-van Mil
OBJECTIVE: Although anticitrullinated protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) have different aetiopathology, the clinical presentation at the time of diagnosis is similar. This study evaluated whether there are phenotypic differences in the symptomatic pre-RA phase. METHODS: Patients with arthralgia included in the Leiden clinically suspect arthralgia cohort who developed arthritis during follow-up were studied (n=67). Symptoms at symptom onset, symptoms and signs at presentation with arthralgia and time to arthritis development were compared between ACPA-positive and ACPA-negative patients...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606797/do-factor-v-leiden-and-prothrombin-g20210a-mutations-predict-recurrent-venous-thromboembolism-in-older-patients
#5
Marie Méan, Andreas Limacher, Odile Stalder, Anne Angelillo-Scherrer, Lorenzo Alberio, Pierre Fontana, Hans-Jürg Beer, Nicolas Rodondi, Bernhard Lämmle, Drahomir Aujesky
BACKGROUND: The value of genetic thrombophilia testing in elderly patients with an unprovoked venous thromboembolism is unclear. We assessed whether the factor V Leiden and the prothrombin G20210A mutation are associated with recurrent venous thromboembolism in elderly patients in a prospective multicenter cohort study. METHODS: We genotyped the factor V Leiden and the prothrombin G20210A mutation in 354 consecutive in- and outpatients aged ≥65 years with a first unprovoked venous thromboembolism from nine Swiss hospitals...
June 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28603947/thrombophilic-gene-polymorphisms-and-recurrent-pregnancy-loss-in-greek-women
#6
M Chatzidimitriou, D Chatzidimitriou, M Mavridou, C Anetakis, F Chatzopoulou, T Lialiaris, S Mitka
INTRODUCTION: Recurrent pregnancy loss (RPL) is a multifactorial disorder. The aim of this study was the detection of various genetic polymorphisms and their correlation to RPL, in Greek women. METHODS: The impact of 12 thrombophilic polymorphisms was evaluated, among 48 Greek women with a history of RPL, vs 27 healthy parous women. Multiplex PCR and in situ hybridization on nitrocellulose films were performed, to investigate 12 genetic polymorphisms previously reported as risk factors for RPL...
June 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28601249/the-2010-acr-eular-criteria-are-not-sufficiently-accurate-in-the-early-identification-of-autoantibody-negative-rheumatoid-arthritis-results-from-the-leiden-eac-and-espoir-cohorts
#7
Debbie M Boeters, Cécile Gaujoux-Viala, Arnaud Constantin, Annette H M van der Helm-van Mil
OBJECTIVES: The 2010 ACR/EULAR criteria were derived to classify rheumatoid arthritis (RA) earlier in time. Previous studies indeed observed that the 2010 criteria were fulfilled earlier than the 1987 criteria. This study determined whether the 2010 criteria perform equally in early classification of autoantibody-positive and autoantibody-negative RA. METHODS: From the total Leiden-EAC (n = 3448) and ESPOIR (n = 813) RA patients who fulfilled the 1987 RA criteria at 1 year but not at presentation were selected (n = 463 and n = 53, respectively), as these patients were classified with delay with the 1987 criteria...
April 29, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28600052/does-exist-a-correlation-between-endometriosis-and-thrombophilic-disorders-a-pilot-study
#8
Roberto Paradisi, Giulia Ferrini, Carlotta Matteucci, Chiara Facchini, Letizia Zannoni, Renato Seracchioli
OBJECTIVE: At present, there is growing evidence of the existence of a genetic predisposition in both thrombophilic disorders and endometriosis. The aim of our study was to evaluate for the first time the prevalence of some thrombophilic disorders in patients with endometriosis. MATERIALS AND METHODS: We conducted a retrospective study on 138 patients with endometriosis and 278 healthy control women. All women were subjected to a blood examination testing for thrombophilic screening and the variables examinated were: hyperhomocysteinemia, factor V Leiden and factor II prothrombin G20210A mutations in heterozygosis and homozigosis...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28596716/cognitive-reactivity-cultural-adaptation-and-psychometric-testing-of-the-persian-version-of-the-leiden-index-of-depression-sensitivity-revised-leids-r-in-an-iranian-sample
#9
Shahla Ostovar, Mariani Binti Md Nor, Mark D Griffiths, Soghra Akbari Chermahini
Cognitive reactivity (CR) to the experimental induction of sad mood has been found to predict relapse in recovered depressed patients. The Leiden Index of Depression Sensitivity Revised (LEIDS-R) is a self-report measure of CR. The aim of the present study was to establish the validity and reliability of the Persian version of the LEIDS-R. The participants were recovered depressed and non-depressed Iranian individuals (n = 833). The analyses included content validation, factor analysis, construct validity, and reliability testing...
2017: International Journal of Mental Health and Addiction
https://www.readbyqxmd.com/read/28587665/hospitalization-for-community-acquired-febrile-urinary-tract-infection-validation-and-impact-assessment-of-a-clinical-prediction-rule
#10
Janneke E Stalenhoef, Willize E van der Starre, Albert M Vollaard, Ewout W Steyerberg, Nathalie M Delfos, Eliane M S Leyten, Ted Koster, Hans C Ablij, Jan W Van't Wout, Jaap T van Dissel, Cees van Nieuwkoop
BACKGROUND: There is a lack of severity assessment tools to identify adults presenting with febrile urinary tract infection (FUTI) at risk for complicated outcome and guide admission policy. We aimed to validate the Prediction Rule for Admission policy in Complicated urinary Tract InfeCtion LEiden (PRACTICE), a modified form of the pneumonia severity index, and to subsequentially assess its use in clinical practice. METHODS: A prospective observational multicenter study for model validation (2004-2009), followed by a multicenter controlled clinical trial with stepped wedge cluster-randomization for impact assessment (2010-2014), with a follow up of 3 months...
June 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28583818/a-multicenter-study-of-1144-patients-with-cerebral-venous-thrombosis-the-venost-study
#11
Taskin Duman, Derya Uluduz, Ipek Midi, Hesna Bektas, Yuksel Kablan, Basak K Goksel, Aysel Milanlioglu, Dilek Necioglu Orken, Ufuk Aluclu
BACKGROUND: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. METHODS: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution...
June 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28580443/reduced-prothrombinase-inhibition-by-tissue-factor-pathway-inhibitor-contributes-to-the-factor-v-leiden-hypercoagulable-state
#12
Jeremy P Wood, Lisa M Baumann Kreuziger, Paul E R Ellery, Susan A Maroney, Alan E Mast
Activated factor V (FVa) and factor X (FXa) form prothrombinase, which converts prothrombin to thrombin. The α isoform of tissue factor (TF) pathway inhibitor (TFPI) dampens early procoagulant events, partly by interacting with FV. FV Leiden (FVL) is the most common genetic thrombophilia in Caucasians. Thrombosis risk is particularly elevated in women with FVL taking oral contraceptives, which produce acquired TFPIα deficiency. In mice, FVL combined with 50% reduction in TFPI causes severe thrombosis and perinatal lethality...
February 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/28575351/-enquire-into-all-the-circumstances-of-the-patient-narrowly-john-rutherford-s-clinical-lectures-in-edinburgh-1749-53
#13
Stephen C Craig
Early eighteenth-century Edinburgh provided a unique learning environment for aspiring practitioners: one in which the unity of medicine and surgery was appreciated and clinical observations and a reasoning practitioner became the well spring of proper patient care. John Rutherford, a surgical apprentice in this environment, student on the wards of London hospitals and under Boerhaave at Leiden, became one of the original medical professors at the University of Edinburgh medical school in 1726. Rutherford taught the popular, theory-based Practice of Medicine for twenty-two years...
May 29, 2017: Journal of the History of Medicine and Allied Sciences
https://www.readbyqxmd.com/read/28575076/prevalence-of-colistin-resistance-gene-mcr-1-containing-enterobacteriaceae-in-feces-of-patients-attending-a-tertiary-care-hospital-and-detection-of-a-mcr-1-containing-colistin-susceptible-e-coli
#14
Elisabeth M Terveer, Roel H T Nijhuis, Monique J T Crobach, Cornelis W Knetsch, Karin E Veldkamp, Jairo Gooskens, Ed J Kuijper, Eric C J Claas
The emergence of the plasmid-mediated mcr colistin resistance gene in the community poses a potential threat for treatment of patients, especially when hospitalized. The aim of this study was to determine the prevalence of all currently known mcr mediated colistin resistance gene in fecal samples of patients attending a tertiary care hospital. From November 2014 until July 2015, fecal samples of patients attending the Leiden University Medical Center were collected and screened for presence of mcr using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28574679/depiction-of-a-17th-century-tooth-extraction-a-drawing-by-adriaen-pietersz-van-de-venne-dutch-1589-1662
#15
David A Chernin
A prolific and inventive painter, draftsman, and poet, Adriaen Pietersz van de Venne was born in Delft in 1589. His wealthy parents had fled from Protestant persecution in the Southern (Spanish) Netherlands during the 1580s. Van de Venne was educated in Leiden, where he became part of the vibrant political and intellectual community around the University. He settled in Middleburg, in Zeeland, by 1614; his earliest dated paintings are also from this year. In 1625, van de Venne moved to The Hague, where he remained until his dealth...
2017: Journal of the History of Dentistry
https://www.readbyqxmd.com/read/28569212/the-prevalence-of-acpa-is-lower-in-rheumatoid-arthritis-patients-with-an-older-age-of-onset-but-the-composition-of-the-acpa-response-appears-identical
#16
Debbie M Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Björn Svensson, René E M Toes, Leendert A Trouw, Tom W J Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist, Annette H M van der Helm-van Mil
BACKGROUND: Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflicting. Therefore this multicohort study assessed the age of onset in relation to the presence of autoantibodies. The association with characteristics of the anti-citrullinated protein antibodies (ACPA) response was also explored. METHODS: The 1987 criteria-positive RA patients included in the Leiden EAC, BARFOT, ESPOIR, Umeå and Lund cohorts (n = 3321) were studied at presentation for age of onset and the presence of ACPA, rheumatoid factor (RF) and anti-carbamylated protein (anti-CarP) antibodies...
May 31, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28559287/occult-myeloproliferative-neoplasms-not-so-occult-any-more
#17
Dhauna Karam, Veena Iyer, Bharat Agrawal
Non-cirrhotic, non-malignant portal vein thrombosis (PVT) is commonly secondary to inherited or acquired prothrombotic states. However, even after extensive workup, 25% of patients with PVT have no apparent prothrombotic aetiology identified (idiopathic PVT). Inherited conditions include factor V Leiden, PT mutation and protein C/S/AT deficiency. Acquired conditions include APS, PNH and BCR-ABL 1-negative myeloproliferative neoplasms (MPN). BCR-ABL-1 negative MPNs are the most frequent underlying prothrombotic risk factor for PVT (15%-30%)...
May 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28555380/anti-gliadin-antibodies-in-breast-milk-from-celiac-mothers-on-a-gluten-free-diet
#18
María Roca, Sabine Lisa Vriezinga, Paula Crespo-Escobar, Renata Auricchio, David Hervás, Gemma Castillejo, Maria Carmen Mena, Isabel Polanco, Riccardo Troncone, Maria Luisa Mearin, Carmen Ribes-Koninckx
PURPOSE: To analyze the presence of total IgA and anti-gliadin antibodies (AGA) in BM from CD mothers who follow a gluten-free diet (GFD) and from mothers on a normal gluten-containing diet (ND). METHODS: 218 samples of mature milk were obtained at different months of lactation (1-6) from 83 mothers (2 or more samples per mother) from Italy (Naples), The Netherlands (Leiden) and Spain (Madrid, Valencia and Reus): 42 CD mothers on GFD for more than 2 years and 41 non-CD mothers on a ND...
May 29, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28550071/tubular-discectomy-versus-conventional-microdiscectomy-for-the-treatment-of-lumbar-disc-herniation-long-term-results-of-a-randomised-controlled-trial
#19
Gijsbert M Overdevest, Wilco C Peul, Ronald Brand, Bart W Koes, Ronald Hma Bartels, Wee F Tan, Mark P Arts
BACKGROUND: The reference surgical procedure for the treatment of lumbar disc herniation is open microdiscectomy. Minimal invasive discectomy with tubular retractors is hypothesised to cause less tissue damage and result in lower blood loss, less postoperative pain and faster recovery. We previously reported our 1 and 2-year results, and found no better outcomes of tubular discectomy compared with open microdiscectomy. Until now, no studies on tubular discectomy have reported results with more than 2 years of follow-up...
May 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28544373/genetic-markers-for-inherited-thrombophilia-are-associated-with-fetal-growth-retardation-in-the-population-of-central-russia
#20
Evgeny Reshetnikov, Oksana Zarudskaya, Alexey Polonikov, Olga Bushueva, Valentina Orlova, Evgeny Krikun, Volodymyr Dvornyk, Mikhail Churnosov
AIM: The aim of this study was to examine the role of hereditary thrombophilia in the development of fetal growth retardation (FGR) in the population of Central Russia. METHODS: The case-control study sample included 497 women in the third trimester of pregnancy recruited during 2009-2013. The participants were enrolled into two groups: patients with FGR (n = 250) and controls without FGR (n = 247). The participants were genotyped for four genetic markers of hereditary thrombophilia: factor V Leiden (G > A FV, rs6025), prothrombin (G > A FII, rs1799963), factor VII (G > A FVII, rs6046), and fibrinogen (G > A FI, rs1800790)...
May 19, 2017: Journal of Obstetrics and Gynaecology Research
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