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https://www.readbyqxmd.com/read/28331932/pulmonary-embolism-and-in-situ-pulmonary-artery-thrombosis-in-paediatrics-a-systematic-review
#1
Madhvi Rajpurkar, Tina Biss, Ernest Amankwah, Denise Martinez, Suzan Williams, C Heleen Van Ommen, Neil A Goldenberg
Data on paediatric pulmonary embolism (PE) are scarce. We sought to systematically review the current literature on childhood PE and conducted a search on paediatric PE via PubMed (1946-2013) and Embase (1980-2013). There was significant heterogeneity in reported data. Two patterns were noted: classic thromboembolic PE (TE-PE) and in situ pulmonary artery thrombosis (ISPAT). Mean age of presentation for TE-PE was 14.86 years, and 51 % of cases were males. The commonest method for diagnosis of TE-PE was contrast CT with angiography (74 % of patients)...
March 23, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28329672/vitamin-d-and-skin-aging
#2
Merel A Hamer, Raymond Noordam, Luba M Pardo, Diana Van Heemst, David A Gunn, Tamar Nijsten
BackgroundThe relationship between 25-hydroxyvitamin D and different phenotypes of skin aging (e.g., wrinkles, pigmented spots, telangiectasia, perceived age) is unclear. We investigated the association between vitamin D levels and skin aging phenotypes in middle-aged participants from the Rotterdam Study (RS) and Leiden Longevity Study (LLS).MethodsStandardized facial photographs were taken of North-European participants from the RS (N=3,831; 58.2% female, median age 66.5) and the LLS (N=661; 50.5% female, median age 63...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28318106/lack-of-rivaroxaban-influence-on-a-prothrombinase-based-assay-for-the-detection-of-activated-c-protein-resistance-an-italian-ex-vivo-and-in-vitro-study-in-normal-subjects-and-factor-v-leiden-carriers
#3
G Gessoni, S Valverde, L Valle, F Gessoni, P Caruso, R Valle
INTRODUCTION: Activated protein C resistance (APCr) leads to hypercoagulability and is due, often but not exclusively, to Factor V Leiden (FVL). The aim of this study was to assess the ex vivo and in vitro interference of the direct factor Xa inhibitor rivaroxaban (RIV) on a prothrombinase-based assay for APCr detection. METHODS: An ex vivo study was performed on fresh plasma samples obtained from 44 subjects with FV wild-type and seven with FVL heterozygous, all treated with RIV...
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28317214/characterization-of-blood-flow-through-intrapulmonary-arteriovenous-anastomoses-and-patent-foramen-ovale-at-rest-and-during-exercise-in-stroke-and-transient-ischemic-attack-patients
#4
Rinaldo Romac, Otto Barak, Duska Glavas, Zora Susilovic Grabovac, Petar Lozo, Igor Roje, Kresimir Caljkusic, Irena Drmic-Hofman, James T Davis, Zeljko Dujic, Andrew T Lovering
OBJECTIVES: We determined whether stroke and/or TIA subjects have exercise-induced blood flow through intrapulmonary arteriovenous anastomoses (QIPAVA ) and/or patent foramen ovale (QPFO ) and a genetic predisposition for ischemic stroke. METHODS: Twenty-eight stroke and/or TIA subjects (33-63 years old) underwent transthoracic saline contrast echocardiography concomitant with transcranial Doppler to detect QIPAVA and QPFO at rest and during supine exercise with and without breathing 100% O2 ...
March 19, 2017: Echocardiography
https://www.readbyqxmd.com/read/28303589/secondary-phenotype-analysis-in-ascertained-family-designs-application-to-the-leiden-longevity-study
#5
Renaud Tissier, Roula Tsonaka, Simon P Mooijaart, Eline Slagboom, Jeanine J Houwing-Duistermaat
The case-control design is often used to test associations between the case-control status and genetic variants. In addition to this primary phenotype, a number of additional traits, known as secondary phenotypes, are routinely recorded, and typically, associations between genetic factors and these secondary traits are studied too. Analysing secondary phenotypes in case-control studies may lead to biased genetic effect estimates, especially when the marker tested is associated with the primary phenotype and when the primary and secondary phenotypes tested are correlated...
March 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28293147/a-case-of-pulmonary-thromboembolism-due-to-coagulation-factor-v-leiden-in-japan%C3%A2-%C3%A2-usefulness-of-next-generation-sequencing
#6
Daisuke Sueta, Miwa Ito, Mitsuhiro Uchiba, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Satoru Shinriki, Seiji Hokimoto, Hirotaka Matsui, Kenichi Tsujita
BACKGROUND: Because the venous thromboembolisms (VTEs) due to the coagulation factor V R506Q (FV Leiden) mutation is often seen in Caucasians, the VTE onset in Japan has not been reported. CASE PRESENTATION: A 34-year-old man from north Africa experiencing sudden dyspnea went to a hospital for advice. The patient had pain in his right leg and a high plasma D-dimer level. A contrast-enhanced computed tomography scan revealed a contrast deficit in the bilateral pulmonary artery and in the right lower extremity...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28287382/effect-of-dabigatran-on-a-prothrombinase-based-assay-for-detecting-activated-protein-c-resistance-an-ex-vivo-and-in-vitro-study-in-normal-subjects-and-factor-v-leiden-carriers
#7
Gianluca Gessoni, Sara Valverde, Letizia Valle, Pierpaolo Caruso, Francesca Gessoni, Roberto Valle
BACKGROUND: The aim of this study was to evaluate ex vivo and in vitro interference of a direct factor IIa inhibitor, dabigatran, on a prothrombinase-based assay to detect activated protein C resistance. MATERIALS AND METHODS: An ex vivo study was performed in six heterozygous factor V Leiden carriers and 12 normal subjects without the factor V Leiden mutation who were treated with dabigatran. An in vitro study was also performed considering 12 plasma samples (six from normal subjects and six from heterozygous factor V Leiden carriers) spiked with dabigatran...
March 7, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28283528/rheumatoid-arthritis-phenotype-at-presentation-differs-depending-on-the-number-of-autoantibodies-present
#8
V F A M Derksen, S Ajeganova, L A Trouw, A H M van der Helm-van Mil, I Hafström, T W J Huizinga, R E M Toes, B Svensson, D van der Woude
OBJECTIVES: In rheumatoid arthritis (RA), seropositive and seronegative disease may be two entities with different underlying pathophysiological mechanisms, long-term outcomes and disease presentations. However, the effect of the conjoint presence of multiple autoantibodies, as proxy for a more pronounced humoral autoimmune response, on clinical phenotype remains unclear. Therefore, this study investigates the association between the number of autoantibodies and initial clinical presentation in two independent cohorts of patients with early RA...
April 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28281093/maternal-acceptability-of-pulse-oximetry-screening-at-home-after-home-birth-or-very-early-discharge
#9
Ilona C Narayen, Adrian A Kaptein, Janine A Hogewoning, Nico A Blom, Arjan B Te Pas
The Netherlands has a unique perinatal healthcare system with a high rate of home births and very early discharge after delivery in hospital. Although we demonstrated that pulse oximetry (PO) screening for critical congenital heart disease is feasible in the Netherlands, it is unknown whether parents find the screening acceptable when performed in home birth setting. We assessed the acceptability of PO screening to mothers after screening in home setting. A questionnaire was sent electronically to mothers who gave birth and/or had postnatal care under supervision of a community midwife participating in the Pulse Oximetry Leiden Screening (POLS) study, a feasibility study of PO screening in the Dutch care system, performed in the Leiden region, the Netherlands...
March 9, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28267062/allodynia-in-cluster-headache
#10
Leopoldine A Wilbrink, Mark A Louter, Onno Pm Teernstra, Erik W van Zwet, Frank Jpm Huygen, Joost Haan, Michel D Ferrari, Gisela M Terwindt
Cutaneous allodynia is an established marker for central sensitization in migraine. There is debate whether cutaneous allodynia may also occur in cluster headache, another episodic headache disorder. Here we examined the presence and severity of allodynia in a large well-defined nation-wide population of people with cluster headache.Using validated questionnaires we assessed, cross-sectionally, ictal allodynia and comorbid depression and migraine in the nation-wide "Leiden University Cluster headache neuro-Analysis" (LUCA) study...
March 4, 2017: Pain
https://www.readbyqxmd.com/read/28262227/gender-related-differences-in-the-outcome-of-patients-with-venous-thromboembolism-and-thrombophilia
#11
Inna Tzoran, Emmanouil Papadakis, Benjamin Brenner, Reina Valle, Luciano López-Jiménez, Fernando García-Bragado, Antoni Riera-Mestre, Aurora Villalobos, Roberto Quintavalla, Manuel Monreal
BACKGROUND: In patients with venous thromboembolism (VTE) and factor V Leiden (FVL) or prothrombin 20210G-A mutation (PTM), the influence of gender on outcome has not been consistently studied. METHODS: We used the RIETE (Registro Informatizado Enfermedad TromboEmbolica) database to assess the existence of gender differences in the rate of VTE recurrences (deep vein thrombosis [DVT] or pulmonary embolism [PE]) or major bleeding during the course of anticoagulation and after its discontinuation in FVL and PTM carriers...
March 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28260578/kenneth-g-zysk-the-indian-system-of-human-marks-leiden-brill-2015-pp-%C3%A2-xvi-954-2%C3%A2-vols-%C3%A2-249-00-hardback-and-e-book-isbn-9789004299726
#12
https://www.readbyqxmd.com/read/28259966/a-genetic-risk-factor-for-thrombophilia-in-a-han-chinese-family
#13
Guoping Sun, Yicong Jia, Jingye Meng, Minglin Ou, Peng Zhu, Shan Cong, Yadan Luo, Weiguo Sui, Yong Dai
Thrombophilia is a multifactorial disorder involving environmental and genetic factors. Well‑known factors that result in predisposition to congenital disorders associated with thrombophilia include antithrombin deficiency, protein C and S deficiency, Factor V Leiden mutation, abnormal prothrombin and antiphospholipid syndrome. The present study revealed an association between a mutation of the F2 gene, which codes for coagulation factor II, thrombin, and the risk of thrombophilia in a Han Chinese family, of which four members (I‑2, II‑2, II‑3 and III‑1) had a history of deep venous thromboembolism...
February 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28258054/thrombophilia-risk-is-not-increased-in-children-after-perinatal-stroke
#14
Colleen Curtis, Aleksandra Mineyko, Patricia Massicotte, Michael Leaker, Xiu Yan Jiang, Amalia Floer, Adam Kirton
Perinatal stroke causes cerebral palsy and lifelong disability. Specific diseases are definable but mechanisms are poorly understood. Evidence suggests possible associations between arterial perinatal stroke and prothrombotic disorders but population-based, controlled, disease-specific studies are limited. Understanding thrombophilia in perinatal stroke informs pathogenesis models and clinical management. We conducted a population-based, prospective, case-control study to determine the association of specific perinatal stroke diseases with known thrombophilias...
March 3, 2017: Blood
https://www.readbyqxmd.com/read/28222826/fetal-and-neonatal-exposure-to-trans-fatty-acids-impacts-on-susceptibility-to-atherosclerosis-in-apo-e-3-leiden-mice
#15
Louise Gates, Simon C Langley-Evans, Jana Kraft, Adam L Lock, Andrew M Salter
Nutrition during pregnancy can impact on the susceptibility of the offspring to CVD. Postnatal consumption of trans-fatty acids (TFA), associated with partially hydrogenated vegetable oil (PHVO), increases the risk of atherosclerosis, whereas evidence for those TFA associated with ruminant-derived dairy products and meat remain equivocal. In this study, we investigate the impact of maternal consumption of dietary PHVO (P) and ruminant milk fat (R) on the development of atherosclerosis in their offspring, using the transgenic apoE*3 Leiden mouse...
February 22, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28216116/pain-sensitivity-and-pain-scoring-in-patients-with-morbid-obesity
#16
Bart Torensma, Linda Oudejans, Monique van Velzen, Dingeman Swank, Marieke Niesters, Albert Dahan
BACKGROUND: There are indications that pain perception is altered in patients with obesity, which complicates postoperative pain treatment. An essential part for adequate pain treatment is the capacity of the patient to grade pain. OBJECTIVES: The aim of this study was to identify the differences in pain perception and pain processing in patients with without obesity. SETTING: Dutch Obesity Clinic West; private practice and the Leiden University Medical Center, the Netherlands; university hospital...
January 10, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28211163/new-functional-assays-to-selectively-quantify-the-apc-and-tfpi-cofactor-activities-of-protein-s-in-plasma
#17
N Alshaikh, J Rosing, M C L G D Thomassen, E Castoldi, P Simioni, T M Hackeng
BACKGROUND: Protein S plays an important role in the down-regulation of coagulation as cofactor for activated protein C (APC) and tissue factor pathway inhibitor (TFPI). AIM: To develop functional assays to quantify the APC- and TFPI-cofactor activities of protein S in plasma. METHODS: APC- and TFPI-cofactor activities of protein S in plasma were measured using calibrated automated thrombography in protein S-depleted plasma supplemented with a small amount of sample plasma either in the presence of anti-TFPI antibodies and APC (APC-cofactor activity) or at excess full-length TFPI without APC (TFPI-cofactor activity)...
February 17, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28209638/the-effect-of-implementing-an-automated-oxygen-control-on-oxygen-saturation-in-preterm-infants
#18
H A Van Zanten, K L A M Kuypers, B J Stenson, T E Bachman, S C Pauws, A B Te Pas
OBJECTIVE: To evaluate the effect of implementing automated oxygen control as routine care in maintaining oxygen saturation (SpO2) within target range in preterm infants. METHODS: Infants <30 weeks gestation in Leiden University Medical Centre before and after the implementation of automated oxygen control were compared. The percentage of time spent with SpO2 within and outside the target range (90-95%) was calculated. SpO2 values were collected every minute and included for analysis when infants received extra oxygen...
February 16, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28209542/social-anxiety-and-the-cortisol-response-to-social-evaluation-in-children-and-adolescents
#19
Esther van den Bos, Mattie Tops, P Michiel Westenberg
Contradictory findings have been reported on the relation between social anxiety and the cortisol response to social evaluation in youth. The present longitudinal study aimed to clarify this relation by taking pubertal development into account. Data were collected in two waves, two years apart, for a community sample of 196 participants, aged 8-17 years at Time 1. Pubertal development and social anxiety were assessed with self-report questionnaires. Salivary cortisol was obtained before and after participants completed the Leiden Public Speaking Task...
February 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28203573/multiple-brain-abscesses-in-an-immunocompetent-patient-with-factor-v-leiden-mutation
#20
Saeed Zubair Zafar, Najwa Pervin, Sukesh Manthri, Mukul Bhattarai
Multiple brain abscesses in an immunocompetent patient is a challenging clinical problem in the medical world despite advances in imaging techniques, laboratory diagnostics, surgical interventions, and antimicrobial treatment. It is a clinical entity that typically tends to occur in the presence of known predisposing factors. Clinicians seek to determine the potential risk factors responsible for the development of brain abscess because it is very crucial for management of this life-threatening condition. At times, like in our case, there are clinical situations where it is difficult to reveal any traditional risk factors...
October 2016: Journal of Investigative Medicine High Impact Case Reports
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