Érica Vanessa Furlan Rosa, Alice Rosa Da Silveira, Marcel Henrique Marcondes Sari, Tuane Bazanella Sampaio, Jamila Trindade Dos Santos, Sabrina Grendene Müller, Michele Rechia Fighera, Luiz Fernando Freire Royes, Cristina Wayne Nogueira, Mauro Schneider Oliveira, Ana Flávia Furian
Aspartame (ASP) is a common sweetener, but studies show it can harm the nervous system, causing learning and memory deficits. β-caryophyllene (BCP), a natural compound found in foods, including bread, coffee, alcoholic beverages, and spices, has already described as a neuroprotector agent. Remarkably, ASP and BCP are commonly consumed, including in the same meal. Therefore, considering that (a) the BCP displays plenty of beneficial effects; (b) the ASP toxicity; and (c) that they can be consumed in the same meal, this study sought to investigate if the BCP would mitigate the memory impairment induced by ASP in rats and investigate the involvement of the brain-derived neurotrophic factor (BDNF)/ tropomyosin receptor kinase B (TrKB) signaling pathway and acetylcholinesterase (AChE) activity...
September 13, 2023: Behavioural Brain Research