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Laura Poddighe, Gianfranca Carta, Maria Pina Serra, Tiziana Melis, Marianna Boi, Sara Lisai, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni, Marina Quartu
BACKGROUND: The transient global cerebral hypoperfusion/reperfusion achieved by induction of Bilateral Common Carotid Artery Occlusion followed by Reperfusion (BCCAO/R) has been shown to stimulate early molecular changes that can be easily traced in brain tissue and plasma, and that are indicative of the tissue physiological response to the reperfusion-induced oxidative stress and inflammation. The aim of the present study is to probe the possibility to prevent the molecular changes induced by the BCCAO/R with dietary natural compounds known to possess anti-inflammatory activity, such as the phytocannabinoid beta-caryophyllene (BCP)...
February 5, 2018: Lipids in Health and Disease
Angel Meza, Christian Lehmann
Sepsis is a clinical condition resulting from a dysregulated immune response to an infection that leads to organ dysfunction. Despite numerous efforts to optimize treatment, sepsis remains to be the main cause of death in most intensive care units. The endogenous cannabinoid system (ECS) plays an important role in inflammation. Cannabinoid receptor 2 (CB2R) activation is immunosuppressive, which might be beneficial during the hyper-inflammatory phase of sepsis. Beta-caryophyllene (BCP) is a non-psychoactive natural cannabinoid (phytocannabinoid) found in Cannabis sativa and in essential oils of spices and food plants, that acts as a selective agonist of CB2R...
January 2018: Medical Hypotheses
Bimal Kumar Ghimire, Ji Hye Yoo, Chang Yeon Yu, Ill-Min Chung
OBJECTIVE: To investigate the composition of volatile compounds in the different accessions of Perilla frutescens (P. frutescens) collected from various habitats of China and Japan. METHODS: In the present study, the essential oil from the leaves of P. frutescens cultivars from China and Japan was extracted by hydro-distillation and the chemical composition and concentration of the volatile components present in the oils were determined by gas chromatography-mass spectrometry (GC-MS) analysis...
July 2017: Asian Pacific Journal of Tropical Medicine
Koly Aktar, Tahira Foyzun
Citrus macroptera (family Rutaceae), commonly known as Sat Kara, is a pharmacologically diverse medicinal plant. Various parts of this plant, specifically fruit, have an immense range of medicinal uses in folk medicine directed for a number of ailments. A plethora of active phytochemical constituents of this plant have been revealed so far, namely, limonene, beta-caryophyllene, beta-pinene, geranial edulinine, ribalinine, isoplatydesmine, and so forth. Several studies demonstrated the exploration of pharmacological potential of various parts such as fruits, leaves, and stems of C...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Bo Feng, Kai Qian, Yong-Jun Du
Abstract: We investigated the role of floral odors from cowpea, Vigna unguiculata (L.), in mediating oviposition of the bean pod borer moth, Maruca vitrata, a serious pest of grain legumes that flies to host plants at the flowering stage and oviposits onto flowers and buds. The flower of the host plant V. unguiculata was a stimulus for egg-laying by M. vitrata in an oviposition bioassay. Commercial longifolene, β-caryophyllene, linalool, geraniol, and (Z)-3-hexenyl acetate were used as stimulus. Each one elicited dose-dependent electroantennogram responses in female M...
June 9, 2017: Insects
D Andrys, M Adaszyńska-Skwirzyńska, D Kulpa
The aim of the present study was to determine the effect of jasmonic acid added to the culture medium on composition of Lavandula angustifolia essential oils. The chemical composition was determined by gas chromatography coupled to mass detector (GC/MS). The experiment was conducted with the use of MS medium supplemented with increasing concentration of JA (0.2, 0.5, 1, 1.5 mg∙dm-3 ). It was found that the analysed essential oils varied in terms of chemical composition depending on the content of JA in the medium...
April 2018: Natural Product Research
Stefania Suta, Filippo Maggi, Marcello Nicoletti, Valeria Baldan, Stefano Dall Acqua
Sesquiterpene are natural products that have been extensively studied for their bioactivities, evidencing their potentiality as useful scaffolds for the development of drugs. Considering the different derivatives, the sesquiterpene lactones have been evaluated, especially on cancer cell and antineoplastic efficacy in in vivo studies. Their bioactivity is strictly related to the presence of the reactive α-methylene-γ-lactone group (αMγL). Nevertheless, several other sesquiterpene lacking of the αMγL are known and have been studied for their biological effects and potential usefulness in the development of new drugs...
April 4, 2017: Current Medicinal Chemistry
B Sundararajan, B D Ranjitha Kumari
The Aedes aegypti L. mosquito transmits dengue and yellow fever, which cause millions of death every year. Dengue is a mosquito-borne viral disease that has rapidly spread worldwide particularly in countries with tropical and subtropical climates areas. The present study denotes a simple and eco-friendly biosynthesis of gold nanoparticles using Artemisia vulgaris L. leaf extract as reducing agent. The synthesized gold nanoparticles were characterized by UV-Visible Spectroscopy, X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Dynamic Light Scattering (DLS), Zeta Potential (ZP), Transmission Electron Microscopy (TEM) and Energy Dispersive X-ray Spectroscopy (EDX)...
September 2017: Journal of Trace Elements in Medicine and Biology
Shinichi Enami, A J Colussi
In the troposphere, the fate of gas-phase Criegee intermediates (CIs) is deemed to be determined by their reactions with water molecules. Here it is shown that CIs produced in situ on the surface of water/acetonitrile (W/AN) solutions react competitively with millimolar carboxylic acids. Present experiments probe, via online electrospray mass spectrometry, CIs' chemistry on the surface of α-humulene and β-caryophyllene in W/AN microjets exposed to O3 (g) for <10 μs. Mass-specific identification lets us establish the progeny of products and intermediates generated in the early stages of CIs' reactions with H2 O, D2 O, H2 18 O, and n-alkyl-COOH (n = 1-7)...
April 6, 2017: Journal of Physical Chemistry Letters
Zoltan V Varga, Csaba Matyas, Katalin Erdelyi, Resat Cinar, Daniela Nieri, Andrea Chicca, Balazs Tamas Nemeth, Janos Paloczi, Tamas Lajtos, Lukas Corey, Gyorgy Hasko, Bin Gao, George Kunos, Jürg Gertsch, Pal Pacher
BACKGROUND AND AIMS: β-Caryophyllene (BCP) is a plant-derived FDA approved food additive with anti-inflammatory properties. Some of its beneficial effects in vivo are reported to involve activation of cannabinoid CB2 receptors that are predominantly expressed in immune cells. Here, we evaluated the translational potential of BCP using a well-established model of chronic and binge alcohol-induced liver injury. METHODS: In this study, we investigated the effects of BCP on liver injury induced by chronic plus binge alcohol feeding in mice in vivo by using biochemical assays, real-time PCR and histology analyses...
January 2018: British Journal of Pharmacology
Kohei Matsuoka, Yosuke Sakamoto, Tetsuya Hama, Yoshizumi Kajii, Shinichi Enami
Sesquiterpenes emitted from biogenic sources play important roles in atmospheric HOx cycles and new particle formation. Current atmospheric models, however, fail to account for their fates, possibly due to missing heterogeneous sinks. Here we apply interface-specific mass spectrometry to detect carbocation products of the reactive uptake of gaseous sesquiterpenes C15 H24 (β-caryophyllene (β-C), α-humulene (α-H), and alloaromadendrene (a-d)) on the surface of aqueous microjets as functions of water acidity and gas concentration...
February 2, 2017: Journal of Physical Chemistry. A
Neife Aparecida Guinaim Santos, Nádia Maria Martins, Flávia Malvestio Sisti, Laís Silva Fernandes, Rafaela Scalco Ferreira, Osvaldo de Freitas, Antônio Cardozo Santos
Beta-caryophyllene (BCP) is a phytocannabinoid whose neuroprotective activity has been mainly associated with selective activation of cannabinoid-type-2 (CB2) receptors, inhibition of microglial activation and decrease of inflammation. Here, we addressed the potential of BCP to induce neuritogenesis in PC12 cells, a model system for primary neuronal cells that express trkA receptors, respond to NGF and do not express CB2 receptors. We demonstrated that BCP increases the survival and activates the NGF-specific receptor trkA in NGF-deprived PC12 cells, without increasing the expression of NGF itself...
January 5, 2017: Chemico-biological Interactions
Aakanksha Pant, Shilpi K Saikia, Virendra Shukla, Jyotsna Asthana, Bashir A Akhoon, Rakesh Pandey
No abstract text is available yet for this article.
December 1, 2016: Experimental Gerontology
Carlos Chaverri, José F Cicció
Pitnenta is a genus of flowering plants in the Myrtaceae family, which has about 15 species, mostly found in the Caribbean region of the Americas. Commonly used for culinary and medicinal purposes, the best known commercial species are allspice, P. dioica (P. officinalis) and bay rum, P. racemosa, but there is little information concerning P. guatemalensis. The aim of the present study was to identify the chemical composition of the leaf and fruit essential oils ofP. guatemalensis. The extraction of essential oils of P...
March 2015: Revista de Biología Tropical
Bart Steenackers, Luc De Cooman, Dirk De Vos
The annual production of hops (Humulus lupulus L.) exceeds 100,000 mt and is almost exclusively consumed by the brewing industry. The value of hops is attributed to their characteristic secondary metabolites; these metabolites are precursors which are transformed during the brewing process into important bittering, aromatising and preservative components with rather low efficiency. By selectively transforming these components off-line, both their utilisation efficiency and functionality can be significantly improved...
April 1, 2015: Food Chemistry
Isela Alvarez-González, Eduardo Madrigal-Bujaidar, Seydi Castro-García
The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse. We found no genotoxic potential of BC, and a significant inhibitory effect on the number of sister-chromatid exchanges (SCE) and chromosomal aberrations induced by BaP. The three tested doses of the agent (20, 200, and 2,000 mg/kg) produced a dose-dependent decrease of the two evaluated cytogenetic parameters. In comparison with the effect induced by BaP, the best inhibitory effect (about 80%) was obtained with the high tested dose of BC considering the two evaluated parameters...
2014: Journal of Toxicological Sciences
Reza Sepahvand, Bahram Delfan, Saeed Ghanbarzadeh, Marzieh Rashidipour, Gholam Hassan Veiskarami, Javad Ghasemian-Yadegari
OBJECTIVE: To determine the chemical composition, antioxidant activity and antibacterial properties of essential oils of the aerial parts of Salvia sclareoides (S. sclareoides). METHODS: The essential oil of the areal parts of S. sclareoides was obtained by using hydrodistillation method and the composition of the volatile components analyzed by gas chromatography method coupled with mass spectrometry detector. The antimicrobial capacity of the essential oil of S...
September 2014: Asian Pacific Journal of Tropical Medicine
Daniele Fraternale, Donata Ricci
The present study reports the results of gas chromatographic-mass spectrometric (GC/MS) analyses of the essential oils from the aerial parts of Ballota nigra L. ssp foetida (Lamiaceae) collected at flowering and fruiting times, as well as their in vitro antifungal activity against nine plant pathogenic fungi. Moreover, the essential oils were evaluated for their antifungal activity using the agar dilution method, and also MICs (minimum inhibitory concentrations) and MFCs (minimum fungicidal concentrations) were determined...
July 2014: Natural Product Communications
Ren Li, Jing-Jing Yang, Yuan-Fei Wang, Qian Sun, Hu-Bin Hu
The present study is the first investigation of the chemical composition, antioxidant, antimicrobial and anti-inflammatory activities of the stem and leaf essential oils from Piper flaviflorum C.DC (SEOP and LEOP), a plant that has been consumed as a wild vegetable, and used as medicine, and spice by the ethnic groups in Xishuangbanna, SW China. Analyzed by GC-MS, 42 and 30 components were identified representing 90.1% and 95.3% of the SEOP and LEOP, with (E)-nerolidol (16.7% and 40.5%), beta-caryophyllene (26...
July 2014: Natural Product Communications
Rajesh K Joshi
The chemical composition of the hydro-distilled essential oil obtained from the flowering aerial parts of Vernonia albicans DC. (Asteraceae) was analyzed by gas chromatography equipped with a flame ionization detector (GC-FID) and gas chromatography coupled with a mass spectrometry (GC/MS). Thirty-nine compounds have been identified, representing 97.5% of the total oil. The major constituents were beta-caryophyllene (34.3%), gamma-amorphene (19.5%), 9-epi-beta-caryophyllene (6.9%), and a-pinene (6.9%). The oil was found to be rich in sesquiterpene hydrocarbons (73...
July 2014: Natural Product Communications
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