keyword
https://read.qxmd.com/read/38383999/association-effect-of-the-phytocannabinoid-beta-caryophyllene-and-indomethacin-carried-in-topical-nanoemulgels-an-evaluation-by-in-vivo-anti-inflammatory-model
#1
JOURNAL ARTICLE
Patrícia Weimer, Graziela de Araújo Lock, Ketly Amaral Antunes Nunes, Rochele Cassanta Rossi, Letícia Scherer Koester
The sesquiterpene β-caryophyllene, classified as a phytocannabinoid compound, has been widely studied owing to its multi-target action. In addition, this compound has demonstrated application as a skin permeation promoter. In this context, this study aimed to evaluate the feasibility of associating β-caryophyllene and indomethacin in the oily core of hydrogel thickened nanoemulsions, as well as, to evaluate the in vivo anti-inflammatory effect of this association by croton oil ear edoema induced model...
February 21, 2024: Natural Product Research
https://read.qxmd.com/read/38008135/-iuphar-review-preclinical-models-of-neuropathic-pain-evaluating-multifunctional-properties-of-natural-cannabinoid-receptors-ligands
#2
JOURNAL ARTICLE
Khalid Benamar
Neuropathic pain remains prevalent and challenging to manage and is often comorbid with depression and anxiety. The new approach that simultaneously targets neuropathic pain and the associated comorbidities, such as depression and anxiety, is timely and critical, given the high prevalence and severity of neuropathic pain and the lack of effective analgesics. In this review, we focus on the animal models of neuropathic pain that researchers have used to investigate the analgesic effects of cannabidiol (CBD) and Beta-Caryophyllene (BCP) individually and in combination while addressing the impact of these compounds on the major comorbidity (e...
November 24, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37958482/correction-mannino-et-al-beta-caryophyllene-exhibits-anti-proliferative-effects-through-apoptosis-induction-and-cell-cycle-modulation-in-multiple-myeloma-cells-cancers-2021-13-5741
#3
Federica Mannino, Giovanni Pallio, Roberta Corsaro, Letteria Minutoli, Domenica Altavilla, Giovanna Vermiglio, Alessandro Allegra, Ali H Eid, Alessandra Bitto, Francesco Squadrito, Natasha Irrera
In the original publication [...].
November 1, 2023: Cancers
https://read.qxmd.com/read/37947792/a-randomized-double-blind-placebo-controlled-repeated-dose-pilot-study-of-the-safety-tolerability-and-preliminary-effects-of-a-cannabidiol-cbd-and-cannabigerol-cbg-based-beverage-powder-to-support-recovery-from-delayed-onset-muscle-soreness-doms
#4
RANDOMIZED CONTROLLED TRIAL
Erica N Peters, Helena Yardley, Amy Harrison, Graham M L Eglit, Jose Antonio, Cynthia Turcotte, Marcel O Bonn-Miller
BACKGROUND: Cannabinoid-containing products are marketed to athletes as promoting recovery, in spite of a lack of data on their safety and effects. This randomized, double-blind, placebo-controlled, repeated-dose pilot study tested the safety, tolerability, and preliminary effects on recovery of a formulation containing cannabidiol (CBD; 35 mg), cannabigerol (CBG; 50 mg), beta caryophyllene (BCP; 25 mg), branched-chain amino acids (BCAAs; 3.8 g), and magnesium citrate (420 mg)...
December 2023: Journal of the International Society of Sports Nutrition
https://read.qxmd.com/read/37919194/mechanisms-of-weight-loss-effect-in-obese-mice-by-the-endogenous-cannabinoid-receptor-2-agonist-beta-caryophyllene
#5
JOURNAL ARTICLE
Chen Jiayao, Wang Jiaoling, Huang Chengyu, Wang Guixiang, Zang Linquan
BACKGROUND AND AIMS: The endogenous cannabinoid system (ECS) is involved in the regulation of a variety of physiological activities in the body, such as metabolism and energy uptake, and cannabinoid receptor 2 (CNR2) is one of these receptors that is predominantly distributed in the periphery. β-caryophyllene (BCP) is an agonist of CNR2 which is known to possess pharmacological activities such as anti-inflammatory and antioxidant properties. In this study, we wanted to investigate whether BCP possesses pharmacological effects on obese mice and its mechanism...
November 1, 2023: Obesity Research & Clinical Practice
https://read.qxmd.com/read/37895166/beta-caryophyllene-a-plant-derived-cb2-receptor-agonist-protects-sh-sy5y-cells-from-cadmium-induced-toxicity
#6
JOURNAL ARTICLE
Federica Mannino, Giovanni Pallio, Chiara Imbesi, Alessandro Scarfone, Domenico Puzzolo, Antonio Micali, José Freni, Francesco Squadrito, Alessandra Bitto, Letteria Minutoli, Natasha Irrera
Cadmium (Cd) is a transition heavy metal that is able to accumulate in the central nervous system and may induce cell death through reactive oxygen species (ROS)-mediated mechanisms and inactivating the antioxidant processes, becoming an important risk factor for neurodegenerative diseases. The antioxidant effects of cannabinoid receptor modulation have been extensively described, and, in particular, β-Caryophyllene (BCP), a plant-derived cannabinoid 2 receptor (CB2R) agonist, not only showed significant antioxidant properties but also anti-inflammatory, analgesic, and neuroprotective effects...
October 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37762646/epicutaneous-sensitization-to-the-phytocannabinoid-%C3%AE-caryophyllene-induces-pruritic-inflammation
#7
JOURNAL ARTICLE
Saadet Inan, Sara J Ward, Citlalli T Baltazar, Gabrielle A Peruggia, Elham Javed, Ajay P Nayak
In recent years, there has been increased accessibility to cannabis for recreational and medicinal use. Incidentally, there has been an increase in reports describing allergic reactions to cannabis including exacerbation of underlying asthma. Recently, multiple protein allergens were discovered in cannabis, yet these fail to explain allergic sensitization in many patients, particularly urticaria and angioedema. Cannabis has a rich chemical profile including cannabinoids and terpenes that possess immunomodulatory potential...
September 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37721992/evaluation-of-the-modulatory-effects-of-minor-cannabinoids-and-terpenes-on-delta-9-tetrahydrocannabinol-discrimination-in-rats
#8
JOURNAL ARTICLE
Catherine F Moore, Julie Marusich, Mehdi Haghdoost, Timothy W Lefever, Marcel O Bonn-Miller, Elise M Weerts
Introduction: Cannabis contains a multitude of phytocannabinoids and terpenes in addition to its main psychoactive constituent, delta-9-tetrahydrocannabinol (D9-THC). It is believed that the combination of minor cannabinoids and terpenes with D9-THC may impact the subjective and physiological effects of D9-THC. In this study, select minor cannabinoids (cannabigerol [CBG], cannabidivarin [CBDV], cannabichromene [CBC], tetrahydrocannabivarin [THCV], cannabigerolic acid [CBGa], and cannabidiolic acid [CBDa]) and terpenes (beta-caryophyllene and linalool) were evaluated for their potential to decrease the interoceptive effects of D9-THC using drug discrimination methods...
September 2023: Cannabis and Cannabinoid Research
https://read.qxmd.com/read/37558167/beta-caryophyllene-mitigates-the-cognitive-impairment-caused-by-repeated-exposure-to-aspartame-in-rats-putative-role-of-bdnf-trkb-signaling-pathway-and-acetylcholinesterase-activity
#9
JOURNAL ARTICLE
Érica Vanessa Furlan Rosa, Alice Rosa Da Silveira, Marcel Henrique Marcondes Sari, Tuane Bazanella Sampaio, Jamila Trindade Dos Santos, Sabrina Grendene Müller, Michele Rechia Fighera, Luiz Fernando Freire Royes, Cristina Wayne Nogueira, Mauro Schneider Oliveira, Ana Flávia Furian
Aspartame (ASP) is a common sweetener, but studies show it can harm the nervous system, causing learning and memory deficits. β-caryophyllene (BCP), a natural compound found in foods, including bread, coffee, alcoholic beverages, and spices, has already described as a neuroprotector agent. Remarkably, ASP and BCP are commonly consumed, including in the same meal. Therefore, considering that (a) the BCP displays plenty of beneficial effects; (b) the ASP toxicity; and (c) that they can be consumed in the same meal, this study sought to investigate if the BCP would mitigate the memory impairment induced by ASP in rats and investigate the involvement of the brain-derived neurotrophic factor (BDNF)/ tropomyosin receptor kinase B (TrKB) signaling pathway and acetylcholinesterase (AChE) activity...
September 13, 2023: Behavioural Brain Research
https://read.qxmd.com/read/37504429/beta-caryophyllene-loaded-nanostructured-lipid-carriers-for-topical-management-of-skin-disorders-statistical-optimization-in-vitro-and-dermatokinetic-evaluation
#10
JOURNAL ARTICLE
Mohammed Ghazwani, Umme Hani, Mohammed H Alqarni, Aftab Alam
This work aimed to overcome the disadvantages of the oral administration of beta-caryophyllene and boost efficiency by developing a nanostructured lipid carrier for topical administration of the drug in skin disorders. The heat emulsification method was utilized to produce beta-caryophyllene-loaded nanostructured lipid carriers. The newly created formulation was examined for its particle size, entrapment efficiency, and zeta potential after being improved using the Box-Behnken Design. The chosen formulation underwent tests to determine its ex vivo skin retention, dermatokinetic, in vitro release, antioxidant, and confocal laser scanning microscopy study...
July 6, 2023: Gels
https://read.qxmd.com/read/37450015/cannabinoid-receptor-2-cb-2-agonists-and-l-arginine-ameliorate-diabetic-nephropathy-in-rats-by-suppressing-inflammation-and-fibrosis-through-nf-%C3%AE%C2%BA%C3%AE-pathway
#11
JOURNAL ARTICLE
Vivek S Kumawat, Ginpreet Kaur
Diabetic nephropathy (DN) is a condition that leads to end-stage chronic kidney disease characterized by inflammation and a deficiency of nitric oxide (NO). Cannabinoid receptor (CB2 ) activation by specific agonist reduces nuclear factor kappa beta (NF-κβ) expression. Beta caryophyllene (BCP), a natural CB2 receptor activator, protects kidney function in several diseases. L-Arginine (LA) modulates several physiological processes by donating nitric oxide (NO). Hence, we tested a novel BCP-LA combination to treat DN and investigated its molecular mechanisms...
July 14, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37241885/antibacterial-and-analgesic-properties-of-beta-caryophyllene-in-a-murine-urinary-tract-infection-model
#12
JOURNAL ARTICLE
Kayle Dickson, Cassidy Scott, Hannah White, Juan Zhou, Melanie Kelly, Christian Lehmann
Beta-caryophyllene has demonstrated anti-inflammatory effects in a variety of conditions, including interstitial cystitis. These effects are mediated primarily via the activation of the cannabinoid type 2 receptor. Additional antibacterial properties have recently been suggested, leading to our investigation of the effects of beta-caryophyllene in a murine model of urinary tract infection (UTI). Female BALB/c mice were intravesically inoculated with uropathogenic Escherichia coli CFT073. The mice received either beta-caryophyllene, antibiotic treatment using fosfomycin, or combination therapy...
May 17, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37128337/repositioning-cannabinoids-and-terpenes-as-novel-egfr-tkis-candidates-for-targeted-therapy-against-cancer-a-virtual-screening-model-using-cadd-and-biophysical-simulations
#13
JOURNAL ARTICLE
Ossama Daoui, Suraj N Mali, Kaouakeb Elkhattabi, Souad Elkhattabi, Samir Chtita
This study examines the potential of Cannabis sativa L. plants to be repurposed as therapeutic agents for cancer treatment through designing of hybrid Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). A set of 50 phytochemicals was taken from Cannabinoids and Terpenes and subjected for screening using Semi-flexible and Flexible Molecular Docking methods, MM-GBSA free binding energy computations, and pharmacokinetic/pharmacodynamic (ADME-Tox) predictions. Nine promising phytochemicals, Cannabidiolic acid (CBDA), Cannabidiol (CBD), Tetrahydrocannabivarin (THCV), Dronabinol (Δ-9-THC), Delta-8-Tetrahydrocannabinol (Δ-8-THC), Cannabicyclol (CBL), Delta9-tetrahydrocannabinolic acid (THCA), Beta-Caryophyllene (BCP), and Gamma-Elemene (γ-Ele) were identified as potential EGFR-TKIs natural product candidates for cancer therapy...
April 2023: Heliyon
https://read.qxmd.com/read/37047034/beta-caryophyllene-modifies-intracellular-lipid-composition-in-a-cell-model-of-hepatic-steatosis-by-acting-through-cb2-and-ppar-receptors
#14
JOURNAL ARTICLE
Rosaria Scandiffio, Sara Bonzano, Erika Cottone, Sujata Shrestha, Simone Bossi, Silvia De Marchis, Massimo E Maffei, Patrizia Bovolin
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease; however, no specific pharmacological therapy has yet been approved for this condition. Plant-derived extracts can be an important source for the development of new drugs. The aim of this study was to investigate the effects of (E)-β-caryophyllene (BCP), a phytocannabinoid recently found to be beneficial against metabolic diseases, on HepG2 steatotic hepatocytes. Using a fluorescence-based lipid quantification assay and GC-MS analysis, we show that BCP is able to decrease lipid accumulation in steatotic conditions and to change the typical steatotic lipid profile by primarily reducing saturated fatty acids...
March 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36903449/gc-ms-analysis-of-the-essential-oil-from-seseli-mairei-h-wolff-apiaceae-roots-and-their-nematicidal-activity
#15
JOURNAL ARTICLE
Shengli Shi, Xinsha Zhang, Xianbin Liu, Zhen Chen, Hewen Tang, Dongbao Hu, Hongmei Li
The essential oil (EO) was extracted from aerial parts with insecticidal and fungicidal activity. Herein, the hydro-distilled essential oils of Seseli mairei H. Wolff roots were determined by GC-MS. A total of 37 components were identified, ( E )-beta-caryophyllene (10.49%), β -geranylgeranyl (6.64%), ( E )-2-decenal (6.17%) and germacrene-D (4.28%). The essential oil of Seseli mairei H. Wolff had nematicidal toxicity against Bursaphelenchus xylophilus with a LC50 value of 53.45 μg/mL. The subsequent bioassay-guided investigation led to the isolation of three active constituents: falcarinol, ( E )-2-decenal, and octanoic acid...
February 27, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36770859/an-update-on-the-therapeutic-anticancer-potential-of-ocimum-sanctum-l-elixir-of-life
#16
REVIEW
Mohammad Raghibul Hasan, Bader Saud Alotaibi, Ziyad Mohammed Althafar, Ahmed Hussain Mujamammi, Jafar Jameela
In most cases, cancer develops due to abnormal cell growth and subsequent tumour formation. Due to significant constraints with current treatments, natural compounds are being explored as potential alternatives. There are now around 30 natural compounds under clinical trials for the treatment of cancer. Tulsi, or Holy Basil, of the genus Ocimum, is one of the most widely available and cost-effective medicinal plants. In India, the tulsi plant has deep religious and medicinal significance. Tulsi essential oil contains a valuable source of bioactive compounds, such as camphor, eucalyptol, eugenol, alpha-bisabolene, beta-bisabolene, and beta-caryophyllene...
January 25, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36755303/systematic-combinations-of-major-cannabinoid-and-terpene-contents-in-cannabis-flower-and-patient-outcomes-a-proof-of-concept-assessment-of-the-vigil-index-of-cannabis-chemovars
#17
JOURNAL ARTICLE
Jacob Miguel Vigil, Sarah See Stith, Franco Brockelman, Keenan Keeling, Branden Hall
BACKGROUND: Little is known about the frequency with which different combinations of phytochemicals (chemovars) arise in Cannabis flower or whether common chemovars are associated with distinct pharmacodynamics and patient health outcomes. This study created a clinically relevant, user-friendly, scalable chemovar indexing system summarizing primary cannabinoid and terpene contents and tested whether the most frequently consumed chemovars differ in their treatment effectiveness and experienced side effects...
February 8, 2023: Journal of cannabis research
https://read.qxmd.com/read/36555111/cannabidiol-and-beta-caryophyllene-in-combination-a-therapeutic-functional-interaction
#18
JOURNAL ARTICLE
Henry Blanton, Linda Yin, Joshua Duong, Khalid Benamar
Cannabis contains over 500 distinct compounds, which include cannabinoids, terpenoids, and flavonoids. However, very few of these compounds have been studied for their beneficial effects. There is an emerging concept that the constituents of the cannabis plant may work in concert to achieve better therapeutic benefits. This study is aimed at determining if the combination of a minor cannabinoid (cannabidiol, CBD) and a terpene (beta-caryophyllene, BCP) works in concert and if this has any therapeutic value...
December 7, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36500446/beta-caryophyllene-enhances-the-anti-tumor-activity-of-cisplatin-in-lung-cancer-cell-lines-through-regulating-cell-cycle-and-apoptosis-signaling-molecules
#19
JOURNAL ARTICLE
Emad A Ahmed, Hamad Abu Zahra, Rebai Ben Ammar, Maged Elsayed Mohamed, Hairul-Islam M Ibrahim
Beta-Caryophyllene (BCP), a natural bicyclic sesquiterpenes, is an abundant biomolecule in red pepper and other plants. Recently, it was reported to reduce the growth and the proliferation as well as enhance the apoptosis in numerous cancer cells, including colorectal, ovarian, bladder cancer and lung cancer. On the other hand, the combination therapy of cisplatin (CDDP) with other phytochemical compounds has synergistically enhanced the killing effect of CDDP on several types of cancer. In the current model, we have tested the role of BCP in enhancing the anti-tumor activity of CDDP on lung cancer cell lines...
November 30, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36419620/corrigendum-exploiting-curcumin-synergy-with-natural-products-using-quantitative-analysis-of-dose-effect-relationships-in-an-experimental-in-vitro-model-of-osteoarthritis
#20
Angela D'Ascola, Natasha Irrera, Roberta Ettari, Alessandra Bitto, Giovanni Pallio, Federica Mannino, Marco Atteritano, Giuseppe M Campo, Letteria Minutoli, Vincenzo Arcoraci, Violetta Squadrito, Giacomo Picciolo, Francesco Squadrito, Domenica Altavilla
[This corrects the article DOI: 10.3389/fphar.2019.01347.].
2022: Frontiers in Pharmacology
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