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https://www.readbyqxmd.com/read/29929133/cytotoxicity-cytokine-release-and-er-stress-autophagy-gene-expression-in-endothelial-cells-and-alveolar-endothelial-co-culture-exposed-to-pristine-and-carboxylated-multi-walled-carbon-nanotubes
#1
Shiwei Chang, Xuqi Zhao, Siyu Li, Tuqiang Liao, Jimin Long, Zhiqiang Yu, Yi Cao
Recently we found that direct exposure of human umbilical vein endothelial cells (HUVECs) to multi-walled carbon nanotubes (MWCNTs) might induce toxicological responses through the modulation of ER stress gene expression, but whether this signal could be transferred from other cells to endothelial cells (ECs) is unknown. This study investigated the toxicity of pristine and carboxylated MWCNTs to HUVECs and alveolar-endothelial co-culture, the later of which could mimic the possible signaling communications between ECs and MWCNT exposed alveolar cells...
June 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29929056/n-acetyl-cysteine-inhibits-lipopolysaccharide-mediated-induction-of-interleukin-6-synthesis-in-mc3t3-e1-cells-through-the-nf-kb-signaling-pathway
#2
Ling Guo, Hui Zhang, Wangyang Li, Danting Zhan, Min Wang
BACKGROUND: Interleukin-6 (IL-6) is a potent stimulator of osteoclastic activity. Lipopolysaccharide (LPS) has been shown to regulate the expression of potent inflammatory factors, including TNF-α and IL-6. Currently, effective therapeutic treatments for bacteria-caused bone destruction are limited. N-acetyl cysteine (NAC) is an antioxidant small molecule that possibly modulates osteoblastic differentiation. However, whether NAC can affect the LPS-mediated reduction of IL-6 synthesis in MC3T3-E1 cells is still unknown...
June 6, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29928998/interleukin-1-in-monocyte-activation-phenotypes-in-systemic-juvenile-idiopathic-arthritis-observations-from-a-clinical-trial-of-rilonacept-an-interleukin-1-inhibitor
#3
Yujuan Zhang, Saloni Gupta, Alexandra Ilstad-Minnihan, Sashi Ayyangar, Arielle D Hay, Virginia Pascual, Norman T Ilowite, Claudia Macaubas, Elizabeth D Mellins
Systemic juvenile idiopathic arthritis (sJIA) is a childhood rheumatic disease of unknown origin. Dysregulated innate immunity is implicated in disease pathology. We investigated if IL-1 inhibition affects circulating cytokines and monocyte gene expression. CD14+ monocytes from patients in the RAPPORT trial were analyzed by RT-PCR for expression of IL1B and transcription factors associated with monocyte activation. Serum IL-1ra decreased with treatment, and IL-18BP transiently increased. Serum levels of IL-1β, IL-6, IL-10 and IL-18 were unchanged...
June 18, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29928969/long-term-exposure-to-environmental-concentrations-of-diesel-exhaust-particles-does-not-impact-the-phenotype-of-human-bronchial-epithelial-cells
#4
Camille C Savary, Nessrine Bellamri, Claudie Morzadec, Sophie Langouët, Valérie Lecureur, Laurent Vernhet
Chronic exposure to diesel engine exhausts is associated with an increased risk of pulmonary diseases including lung cancer. Diesel engine exhausts contain large amounts of diesel exhaust particles (DEP) on which are adsorbed several carcinogenic compounds such as polycyclic aromatic hydrocarbons. Acute toxicity of high concentrations of DEP has been largely demonstrated in various in vitro cellular models. In contrast, the cellular and molecular impacts of low environmental concentrations of DEP on the phenotype of chronically exposed lung epithelial cells remain to be investigated...
June 18, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29928964/spinal-interleukin-10-produces-antinociception-in-neuropathy-through-microglial-%C3%AE-endorphin-expression-separated-from-antineuroinflammation
#5
Hai-Yun Wu, Xiao-Fang Mao, Xue-Qi Tang, Usman Ali, Evhy Apryani, Hao Liu, Xin-Yan Li, Yong-Xiang Wang
Interleukin 10 (IL-10) is antinociceptive in various animal models of pain without induction of tolerance, and its mechanism of action was generally believed to be mediated by inhibition of neuroinflammation. Here we reported that intrathecal IL-10 injection dose dependently attenuated mechanical allodynia and thermal hyperalgesiain male and female neuropathic rats, with ED50 values of 40.8 ng and 24 ng, and Emax values of 61.5% MPE and 100% MPE in male rats. Treatment with IL-10 specifically increased expression of the β-endorphin (but not prodynorphin) gene and protein in primary cultures of spinal microglia but not in astrocytes or neurons...
June 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29928951/higher-serum-levels-of-pro-hepcidin-in-patients-with-parkinson-s-disease-treated-with-deep-brain-stimulation
#6
J Kwiatek-Majkusiak, M Geremek, D Koziorowski, R Tomasiuk, S Szlufik, A Friedman
Hepcidin is an essential hormone responsible for the systemic metabolism of iron and simultaneously belongs to the family of the protein mediators of the acute inflammatory response, primarily induced in response to interleukin 6. It can therefore be regarded as a link between the oxidative stress processes, where iron plays an important role, and the processes of neuroinflammation - both considered to be responsible for the neurodegeneration in Parkinson's disease. We assessed the serum level of pro-hepcidin in patients with Parkinson's disease treated only pharmacologically and those treated additionally with deep brain stimulation (DBS) as compared to the control group...
June 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29928898/transient-high-pressure-in-pancreatic-ducts-promotes-inflammation-and-alters-tight-junctions-via-calcineurin-signaling-in-mice
#7
Li Wen, Tanveer A Javed, Dean Yimlamai, Amitava Mukherjee, Xiangwei Xiao, Sohail Z Husain
BACKGROUND AND AIMS: Pancreatitis following endoscopic retrograde cholangiopancreatography (PEP) is thought to be provoked by pancreatic ductal hypertension, via unknown mechanisms. We investigated the effects of hydrostatic pressures on the development of pancreatitis in mice. METHODS: We performed studies with Swiss Webster mice, B6129 mice (controls), and B6129 mice with disruption of the protein phosphatase 3, catalytic subunit, beta isoform gene (Cnab-/- mice)...
June 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29928887/lipopolysaccharide-mediated-inflammatory-priming-potentiates-painful-post-traumatic-trigeminal-neuropathy
#8
Yves Boucher, Nathan Moreau, Annie Mauborgne, Wisam Dieb
We explored the molecular and behavioral effects of a perineural Lipopolysaccharide (LPS)-mediated inflammatory priming on the development and maintenance of painful post-traumatic trigeminal neuropathy (PPTTN) following infra-orbital nerve chronic constriction injury (CCI-IoN) in rats. Rats were pretreated with repetitive perineural injections in the vicinity of the IoN of either LPS or vehicle (Vhcl) before being submitted to CCI-IoN. Orofacial pain-like behaviors (response to Von Frey Filament testing and spontaneous isolated face grooming) were measured during the period of LPS injections (three weeks) and following CCI-IoN surgery (two weeks)...
June 18, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29928698/maternal-exercise-training-attenuates-endotoxin-induced-sepsis-in-mice-offspring
#9
Mami Yamada, Chihiro Hokazono, Mitsuharu Okutsu
Regular exercise during pregnancy can prevent offspring from several diseases, such as cardiovascular diseases, obesity, and type II diabetes during adulthood. However, little information is available about whether maternal exercises during pregnancy protect the offspring from infectious diseases, such as sepsis and multiple organ dysfunction syndrome (MODS). This study aimed to investigate whether maternal exercise training protects the offspring from endotoxin-induced septic shock in mice. Female C57BL/6 mice performed voluntary wheel exercises during pregnancy...
September 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29928672/neonatal-colonic-inflammation-epigenetically-aggravates-epithelial-inflammatory-responses-to-injury-in-adult-life
#10
Xiaoying S Zhong, John H Winston, Xiuju Luo, Kevin T Kline, Syed Z Nayeem, Yingzi Cong, Tor C Savidge, Roderick H Dashwood, Don W Powell, Qingjie Li
Background & Aims: Early life adversity is considered a risk factor for the development of gastrointestinal diseases, including inflammatory bowel disease. We hypothesized that early life colonic inflammation causes susceptibility to aggravated overexpression of interleukin (IL)1β. Methods: We developed a 2-hit rat model in which neonatal inflammation (NI) and adult inflammation (AI) were induced by trinitrobenzene sulfonic acid. Results: Aggravated immune responses were observed in NI + AI rats, including a sustained up-regulation of IL1β and other cytokines...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29928577/transcriptional-regulation-of-human-amelotin-gene-by-interleukin-1%C3%AE
#11
Mizuho Yamazaki, Masaru Mezawa, Keisuke Noda, Yasunobu Iwai, Sari Matsui, Hideki Takai, Yohei Nakayama, Yorimasa Ogata
One of the major causes of tooth loss is chronic inflammation of the periodontium, the tissues surrounding the tooth. Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. Localization of AMTN suggests that its function could be involved in the dentogingival attachment...
June 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29928502/high-molecular-weight-hyaluronic-acid-a-two-pronged-protectant-against-infection-of-the-urogenital-tract
#12
Catherine A Mowbray, Syema Shams, Git Chung, Anna Stanton, Phillip Aldridge, Andrejus Suchenko, Robert S Pickard, Ased Sm Ali, Judith Hall
Objectives: Recurrent urinary tract infections are associated with uropathogenic Escherichia coli (UPEC) ascending and infecting the urinary tract. Antibiotics provide only symptomatic relief, not prevent recurrence. Clinical evidence suggests that intravesical glycosaminoglycan therapy, such as hyaluronic acid (HA), helps reduce UTI recurrence. This has been investigated here using in vitro systems modelling the urogenital tract tissues. Methods: RT4 bladder cells were preconditioned with high molecular weight HA (> 1500 kDa) at 2 mg mL-1 and challenged with UPEC to analyse barrier protection and bacterial adherence...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29928500/endometrial-response-to-conceptus-derived-estrogen-and-interleukin-1%C3%AE-at-the-time-of-implantation-in-pigs
#13
REVIEW
Hakhyun Ka, Heewon Seo, Yohan Choi, Inkyu Yoo, Jisoo Han
The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines, interleukin-1β2 (IL1B2), interferon-γ (IFNG), and IFN-δ (IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29928449/primary-cauda-equina-lymphoma-diagnosed-by-nerve-biopsy-a-case-report-and-literature-review
#14
Kayo Suzuki, Taketoshi Yasuda, Toshihito Hiraiwa, Masahiko Kanamori, Tomoatsu Kimura, Yoshiharu Kawaguchi
Primary cauda equina lymphoma (CEL) is a rare malignant tumor among various neoplasms that affects the cauda equina nerve roots. The present case report described the case of a 65-year-old man who presented with cauda equina syndrome with progressive motor palsy in the legs and gait disturbance over the last 5 months. Magnetic resonance (MR) images showed enlargement of the cauda equina occupying the dural sac from the L1-S1 level with isointensity to the spinal cord signal on both T1- and T2-weighted imaging...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928442/a-novel-potential-effective-strategy-for-enhancing-the-antitumor-immune-response-in-breast-cancer-patients-using-a-viable-cancer-cell-dendritic-cell-based-vaccine
#15
Mona S Abdellateif, Sabry M Shaarawy, Eman Z Kandeel, Ahmed H El-Habashy, Mohamed L Salem, Motawa E El-Houseini
Dendritic cells (DCs) have been used in a number of clinical trials for cancer immunotherapy; however, they have achieved limited success in solid tumors. Consequently the aim of the present study was to identify a novel potential immunotherapeutic target for breast cancer patients through in vitro optimization of a viable DC-based vaccine. Immature DCs were primed by viable MCF-7 breast cancer cells and the activity and maturation of DCs were assessed through measuring CD83, CD86 and major histocompatibility complex (MHC)-II expression, in addition to different T cell subpopulations, namely CD4+ T cells, CD8+ T cells, and CD4+ CD25+ forkhead box protein 3 (Foxp3)+ regulatory T cells (Tregs), by flow cytometric analysis...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928409/accumulation-of-t-helper-22-cells-interleukin-22-and-myeloid-derived-suppressor-cells-promotes-gastric-cancer-progression-in-elderly-patients
#16
Xuehua Chen, Yanfu Wang, Jiali Wang, Jinhui Wen, Xuzhao Jia, Xiaojun Wang, Hua Zhang
Chronic inflammation and immunosuppression lead to aging and tumorigenesis. T-helper 22 (Th22) cells, interleukin 22 (IL-22) and myeloid-derived suppressor cells (MDSCs) serve an important role in inflammatory-immune diseases and cancer. However, the status of Th22 cells, IL-22 and MDSCs in aging and elderly gastric cancer progression is unknown. In the present study, 39 elderly patients with gastric cancer (EGC), 32 elderly healthy controls (HE) and 31 young healthy controls (HY) were enrolled, and the peripheral Th22, Th17 and Th1 cells, and MDSCs, were examined using flow cytometry...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928398/hydrogen-rich-solution-attenuates-myocardial-injury-caused-by-cardiopulmonary-bypass-in-rats-via-the-janus-activated-kinase-2-signal-transducer-and-activator-of-transcription-3-signaling-pathway
#17
Keyan Chen, Yingjie Sun, Yugang Diao, Tiezheng Zhang, Wanwei Dong
The incidence of complications and mortality following open-heart surgery with cardiopulmonary bypass (CPB) is associated with the severity of the myocardial injury that occurs during surgery. Hydrogen-rich solution (HRS) may prevent antioxidant stress and inhibit apoptosis and inflammation. The present study was designed to investigate the effects of HRS on CPB-induced myocardial injury, and to investigate its potential regulation of the Janus-activated kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928340/activation-of-the-tlr4-myd88-signaling-pathway-contributes-to-the-development-of-human-hepatocellular-carcinoma-via-upregulation-of-il-23-and-il-17a
#18
Yuming Kang, Guoai Su, Jianmin Sun, Yanli Zhang
Toll-like receptor 4 (TLR4) and the interleukin (IL)-23/IL-17A axis serve an important role in tumor immunology. In the present study, the activation of the TLR4/myeloid differentiation primary response 88 (MyD88)-mediated signal transduction pathway in human hepatocellular carcinoma (HCC) cells was examined using immunohistochemistry, and the association between TLR4 expression and the IL-23/IL-17A axis was detected by ELISA, reverse transcription-quantitative polymerase chain reaction and western blot analysis in order to determine whether TLR4 and IL-23/IL-17A serve a role in HCC...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928278/functions-of-cd1d-restricted-invariant-natural-killer-t-cells-in-antimicrobial-immunity-and-potential-applications-for-infection-control
#19
REVIEW
Yuki Kinjo, Shogo Takatsuka, Naoki Kitano, Shun Kawakubo, Masahiro Abe, Keigo Ueno, Yoshitsugu Miyazaki
CD1d-restricted invariant natural killer T ( i NKT) cells are innate-type lymphocytes that express a T-cell receptor (TCR) containing an invariant α chain encoded by the Vα14 gene in mice and Vα24 gene in humans. These i NKT cells recognize endogenous, microbial, and synthetic glycolipid antigens presented by the major histocompatibility complex (MHC) class I-like molecule CD1d. Upon TCR stimulation by glycolipid antigens, i NKT cells rapidly produce large amounts of cytokines, including interferon-γ (IFNγ) and interleukin-4 (IL-4)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29928231/carnosine-prevents-type-2-diabetes-induced-osteoarthritis-through-the-ros-nf-%C3%AE%C2%BAb-pathway
#20
Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, He Zhang, Yi Gang, Lunhao Bai
Background: The anti-inflammatory and antioxidant capacity of carnosine (CAR) has been investigated in autoimmune diseases. The aim of this study was to evaluate the potential protective effects of oral CAR supplements to ameliorate type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and its mechanism. Methods: Seventy male Sprague-Dawley rats were randomly divided into the control group (CG, n = 10) and the T2DM group ( n = 60). A rat model of T2DM was established using a high fat diet and streptozotocin (30 mg/kg, i...
2018: Frontiers in Pharmacology
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