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https://www.readbyqxmd.com/read/29691908/expression-of-cutaneous-immunity-markers-during-infant-skin-maturation
#1
Frank Kirchner, Kimberly A Capone, M Catherine Mack, Georgios N Stamatas
BACKGROUND/OBJECTIVES: Infant skin undergoes a maturation process during the early years of life. Little is known about the skin's innate immunity. We investigated the dynamics of innate immunity markers collected from the surface of infant skin during the first 36 months of life. METHODS: A total of 117 healthy infants aged 3-36 months participated in the study. We extracted human beta defensin-1 and interleukin 1 alpha and its receptor antagonist using transdermal analysis patches from the skin surface of the posterior lower leg area...
April 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29691718/ursodeoxycholic-acid-inhibits-inflammatory-responses-and-promotes-functional-recovery-after-spinal-cord-injury-in-rats
#2
Wan-Kyu Ko, Seong Jun Kim, Min-Jae Jo, Hyemin Choi, Donghyun Lee, Il Keun Kwon, Soo-Hong Lee, In-Bo Han, Seil Sohn
The aim of this study was to investigate the anti-inflammatory effects by ursodeoxycholic acid (UDCA) in rats with a spinal cord injury (SCI). A moderate mechanical compression injury was imposed on adult Sprague-Dawley (SD) rats. The post-injury locomotor functions were assessed using the Basso, Beattie, and Bresnahan (BBB) locomotor scale and the tissue volume of the injured region was analyzed using hematoxylin and eosin staining. The pro-inflammatory factors were evaluated by immunofluorescence (IF) staining, a quantitative real-time polymerase chain reaction (qRT-PCR), and enzyme-linked immunosorbent assay (ELISA)...
March 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29691688/associations-between-interleukin-23r-polymorphisms-and-ankylosing-spondylitis-susceptibility-an-updated-meta-analysis
#3
Y H Lee, G G Song
OBJECTIVE: The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms are associated with susceptibility to ankylosing spondylitis (AS). METHODS: Meta-analyses were conducted to determine the associations between IL-23R polymorphisms and AS susceptibility in Europeans, Asians, and all subjects combined. RESULTS: A total of 17 studies (21 separate comparisons) were included in this meta-analysis. The meta-analysis revealed a significant association between AS and the two alleles of the rs11209032 polymorphism in all study subjects (odds ratio [OR] = 1...
April 24, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29691578/-effects-of-thyroid-hormone-on-macrophage-dysfunction-induced-by-oxidized-low-density-lipoprotein
#4
Yu Ning, Ming Zhang, Yun-Hui DU, Hui-Na Zhang, Lin-Yi Li, Yan-Wen Qin, Wan-Wan Wen, Quan-Ming Zhao
It has been recognized that patients with hypothyroidism have higher risks of atherosclerosis and coronary heart disease, however, the mechanisms are largely unknown. Considering that macrophage dysfunction plays an important role in the formation and development of atherosclerosis plaques, this study aimed to investigate the direct effects of thyroid hormone on macrophage functions and to provide new insight for the mechanism of hypothyroid atherosclerosis. RAW264.7 cells (mouse leukaemic monocyte macrophage cell line) were incubated with oxidized low-density lipoprotein (oxLDL) to establish macrophage foam cells model in vitro, and the protective effects of different concentration of thyroxine (T4) on the macrophage foam cells function were explored...
April 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29691565/-effect-of-rhegf-on-the-levels-of-serum-egf-and-inflammatory-cytokines-in-patients-with-oral-and-maxillofacial-trauma
#5
Zhi-Fa Yin, Si-Ming Wang
PURPOSE: To investigate the effect of debridement combined with recombinant human epidermal growth factor (rhEGF) on wound healing, scar formation, serum epidermal growth factor and inflammatory factors in patients with oral and maxillofacial trauma. METHODS: Eight-two cases with oral and maxillofacial trauma treated in our hospital (January 2015 to December 2016) were retrospectively analyzed. All patients received routine treatment, 41 received rhEGF besides routine treatment (experimental group), 41 patients received only cosmetic debridement and suturing (control group)...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29691532/black-rice-anthocyanin-rich-extract-and-rosmarinic-acid-alone-and-in-combination-protect-against-dss-induced-colitis-in-mice
#6
Lei Zhao, Yali Zhang, Guorong Liu, Shuai Hao, Chengtao Wang, Yong Wang
The aim of this study was to investigate the effect of black rice anthocyanin-rich extract (BRAE) and rosmarinic acid (RA), alone and in combination, on dextran sulfate sodium (DSS)-induced colitis in mice. Results showed that administration of BRAE and RA, alone and in combination, significantly decreased the disease activity index (DAI) and the histological score of colons in DSS-induced colitis mice. Moreover, the administration of BRAE and RA, alone and in combination, not only reduced myeloperoxidase (MPO) and nitric oxide (NO) levels, but also inhibited the expression of pro-inflammatory mediators including interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2...
April 25, 2018: Food & Function
https://www.readbyqxmd.com/read/29691471/baricitinib-induced-blockade-of-interferon-gamma-receptor-and-interleukin-6-receptor-for-the-prevention-and-treatment-of-graft-versus-host-disease
#7
Jaebok Choi, Matthew L Cooper, Karl Staser, Kidist Ashami, Kiran R Vij, Bing Wang, Lynne Marsala, Jessica Niswonger, Julie Ritchey, Bader Alahmari, Samuel Achilefu, Ikuo Tsunoda, Mark A Schroeder, John F DiPersio
The therapeutic benefits of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are derived from the graft-versus-leukemia (GvL) effects of the procedure. There is a strong association between the GvL effects and graft-versus-host disease (GvHD), a major life-threatening complication of allo-HSCT. The limiting of GvHD while maintaining the GvL effect remains the goal of allo-HSCT. Therefore, identifying optimal therapeutic targets to selectively suppress GvHD while maintaining the GvL effects represents a significant unmet medical need...
April 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29691386/toll-like-receptors-mediated-pathways-activate-inflammatory-responses-in-the-esophageal-mucosa-of-adult-eosinophilic-esophagitis
#8
Ángel Arias, María Vicario, David Bernardo, José M Olalla, Marina Fortea, Ana Montalban-Arques, Pilar Martínez-Fernández, Ana M González-Castro, Teresa Mota-Huertas, Laura Arias-González, Alfredo J Lucendo
OBJECTIVES: Esophageal microbiota and regulation of adaptive immunity are increasingly being investigated in eosinophilic esophagitis (EoE). Toll-like receptors (TLRs) play a central role in the initiation and maintenance of innate immune activity. Our objective was to characterize the esophageal and duodenal innate immune response in EoE and its modulation by dietary therapy. METHODS: Esophageal and duodenal biopsy samples were collected from 10 adults with untreated EoE, before and after effective treatment with a six-food elimination diet (SFED), and 10 controls with normal esophagus...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691371/helicobacter-pylori-induced-il-33-modulates-mast-cell-responses-benefits-bacterial-growth-and-contributes-to-gastritis
#9
Yi-Pin Lv, Yong-Sheng Teng, Fang-Yuan Mao, Liu-Sheng Peng, Jin-Yu Zhang, Ping Cheng, Yu-Gang Liu, Hui Kong, Ting-Ting Wang, Xiao-Long Wu, Chuan-Jie Hao, Weisan Chen, Shi-Ming Yang, Yong-Liang Zhao, Bin Han, Qiang Ma, Quan-Ming Zou, Yuan Zhuang
Interleukin (IL)-induced inflammatory responses are critical for the pathogenesis of Helicobacter pylori (H. pylori)-induced gastritis. IL-33 represents a recently discovered proinflammatory cytokine involved in inflammatory diseases, but its relevance to H. pylori-induced gastritis is unknown. Here, we found that gastric IL-33 mRNA and protein expression were elevated in gastric mucosa of both patients and mice infected with H. pylori, which is positively correlated with bacterial load and the degree of gastritis...
April 25, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29691365/plasma-inflammatory-cytokines-and-survival-of-pancreatic-cancer-patients
#10
A Babic, N Schnure, N P Neupane, M M Zaman, N Rifai, M W Welch, L K Brais, D A Rubinson, V Morales-Oyarvide, C Yuan, S Zhang, E M Poole, B M Wolpin, M H Kulke, D A Barbie, K Wong, C S Fuchs, K Ng
OBJECTIVES: Inflammation and inflammatory conditions have been associated with pancreatic cancer risk and progression in a number of clinical, epidemiological, and animal model studies. The goal of the present study is to identify plasma markers of inflammation associated with survival of pancreatic cancer patients, and assess their joint contribution to patient outcome. METHODS: We measured circulating levels of four established markers of inflammation (C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptor type II (sTNF-RII), and macrophage inhibitory cytokine-1 (MIC-1)) in 446 patients enrolled in an ongoing prospective clinic-based study...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691361/salvianolic-acid-b-suppresses-inflammatory-mediator-levels-by-downregulating-nf-%C3%AE%C2%BAb-in-a-rat-model-of-rheumatoid-arthritis
#11
Zeng-Bing Xia, Yong-Jian Yuan, Qiang-Hua Zhang, Heng Li, Ji-Lin Dai, Ji-Kang Min
BACKGROUND Salvianolic acid B (SB) is a major active phyto-component of the plant Radix Salvia miltiorrhiza, which is traditionally used to treat joint pain and arthritis. The present study examined the anti-rheumatoid arthritis efficacy of SB on collagen-induced rheumatoid arthritis (CIA) in a rat model. MATERIAL AND METHODS Forty-eight rats were divided into 4 groups: Control rats treated with saline (Group I), rats subjected to CIA induction by intradermal injection of bovine collagen II type at the tail (Group II), and rats subjected to CIA and supplemented with either 20 or 40 mg/kg of SB for 28 days (group III or IV)...
April 25, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29691298/enhanced-therapeutic-activity-of-non-internalizing-small-molecule-drug-conjugates-targeting-carbonic-anhydrase-ix-in-combination-with-targeted-interleukin-2
#12
Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, Patrizia Murer, Giovanni Pellegrini, Francesca Pretto, Sarah Wulhfard, Dario Neri
PURPOSE: Antibody-drug conjugates and small molecule-drug conjugates have been proposed as alternatives to conventional anti-cancer cytotoxic agents, with the potential to deliver bioactive payloads to the site of disease, helping spare normal tissues. Experimental Design: Here we describe a novel small molecule-drug conjugate, based on a high-affinity ligand specific to carbonic anhydrase IX. The product featured a peptidic linker, suitable for cleavage in the tumor extracellular environment, and monomethyl auristatin E as cytotoxic payload...
April 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29691294/reciprocal-network-between-cancer-stem-like-cells-and-macrophages-facilitates-the-progression-and-androgen-deprivation-therapy-resistance-of-prostate-cancer
#13
Hai Huang, Chao Wang, Fei Liu, Hui-Zhen Li, Guang Peng, Xu Gao, Ke-Qin Dong, Hong-Ru Wang, De-Pei Kong, Min Qu, Li-He Dai, Kai-Jian Wang, Zhe Zhou, Jun Yang, Ze-Yu Yang, Yan-Qiong Cheng, Qin-Qin Tian, Dan Liu, Chuan-Liang Xu, Dan-Feng Xu, Xin-Gang Cui, Ying-Hao Sun
PURPOSE: Cancer stem-like cells (CSCs) contribute to the progression and androgen deprivation therapy (ADT) resistance of prostate cancer. Since CSCs depend on their specific niche, including tumor-associated macrophages (TAMs), elucidating the network between CSCs and TAMs may help to effectively inhibit the progression and ADT resistance of prostate cancer. EXPERIMENTAL DESIGN: The underlying intracellular mechanism that sustains the stem-like characteristics of CSCs in prostate cancer was assessed via RNA-seq, co-IP, ChIP and other assays...
April 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29691190/noni-morinda-citrifolia-l-fruit-juice-delays-immunosenescence-in-the-lymphocytes-in-lymph-nodes-of-old-f344-rats
#14
Uday P Pratap, Hannah P Priyanka, Karthik R Ramanathan, Vishak Raman, Lalgi Hima, Srinivasan Thyagarajan
OBJECTIVE: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni (M. citrifolia) fruit juice (NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats. METHODS: Lymphocytes isolated from axillary and inguinal lymph nodes of young (3-4 months) and old (18-21 months) rats were treated in vitro with different concentrations (0...
April 12, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29690905/resolution-of-bleomycin-induced-murine-pulmonary-fibrosis-via-a-splenic-lymphocyte-subpopulation
#15
Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Jiro Usuki, Minoru Inomata, Akemi Morinaga, Takeru Kashiwada, Nobuhiko Nishijima, Shioto Itakura, Nariaki Kokuho, Kenichiro Atsumi, Hiroki Hayashi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe, Kaoru Kubota, Akihiko Gemma
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality, and the pathogenesis of the disease is still incompletely understood. Although lymphocytes, especially CD4+ CD25+ FoxP3+ regulatory T cells (Tregs), have been implicated in the development of IPF, contradictory results have been reported regarding the contribution of Tregs to fibrosis both in animals and humans. The aim of this study was to investigate whether a specific T cell subset has therapeutic potential in inhibiting bleomycin (BLM)-induced murine pulmonary fibrosis...
April 24, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29690837/neutralization-of-interleukin-1%C3%AE-following-diffuse-traumatic-brain-injury-in-the-mouse-attenuates-the-loss-of-mature-oligodendrocytes
#16
Johanna Flygt, Karsten Ruscher, Amanda Norberg, Anis Mir, Hermann Gram, Fredrik Clausen, Niklas Marklund
Traumatic brain injury (TBI) commonly results in injury to the components of the white matter tracts, causing post-injury cognitive deficits. The myelin-producing oligodendrocytes (OLs) are vulnerable to TBI although may plausibly be replaced by proliferating oligodendrocyte progenitor cells (OPCs). The cytokine interleukin-1β (IL-1β) is a key mediator of the complex inflammatory response, and when neutralized in experimental TBI behavioral outcome was improved. To evaluate the role of IL-1β on OL cell death and OPC proliferation, 116 adult male mice subjected to sham injury or the central fluid percussion injury (cFPI) model of traumatic axonal injury, were analyzed at 2, 7 and 14 days post-injury...
April 25, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29690724/-the-effect-of-berberine-on-ameliorating-chronic-inflammatory-pain-and-depression
#17
F Xu, J Yang, B Meng, J W Zheng, Q Liao, J P Chen, X W Chen
Objective: To explore the effect of berberine on chronic inflammatory pain and the comorbid depression and the associated mechanisms. Methods: Forty healthy male ICR mice (2 months, 25-30 g) were used in the present study. The chronic inflammatory pain was induced by intraplantar injection of complete freund's adjuvant (CFA) to the hind paws. All animals were divided into 4 groups ( n =10 for each group) according to random number table: the saline group (group A), the chronic pain group (group B), the saline+ berberine group (group C) and the chronic pain+ berberine group (group D)...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29690614/cytokine-expression-and-macrophage-localization-in-xenograft-and-allograft-tumor-models-stimulated-with-lipopolysaccharide
#18
Junko Masuda, Tsukasa Shigehiro, Takuma Matsumoto, Ayano Satoh, Akifumi Mizutani, Chiho Umemura, Shoki Saito, Mayumi Kijihira, Eiji Takayama, Akimasa Seno, Hiroshi Murakami, Masaharu Seno
T cell-deficient mice such as nude mice are often used to generate tumor xenograft for the development of anticancer agents. However, the functionality of the other immune cells including macrophages, dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs) in the xenograft are largely unknown. Macrophages and dendritic cells (DCs) acquire functionally distinct properties in response to various environmental stimuli; the interaction of these cells with MDSCs in tumor microenvironments regulates cancer progression...
April 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29689643/il-17a-promotes-the-invasion-metastasis-cascade-via-the-akt-pathway-in-hepatocellular-carcinoma
#19
Qing-Guo Xu, Jian Yu, Xing-Gang Guo, Guo-Jun Hou, Sheng-Xian Yuan, Yuan Yang, Yun Yang, Hui Liu, Ze-Ya Pan, Fu Yang, Fang-Ming Gu, Wei-Ping Zhou
We previously demonstrated that interleukin-17A (IL-17A) is associated with the progression of hepatocellular carcinoma (HCC). However, its role in the invasion-metastasis cascade of HCC and the efficacy of IL-17A-targeting therapeutics in HCC remain largely unknown. In this study, we found that IL-17A promoted intrahepatic and pulmonary metastasis of HCC cells in an orthotopic implant model. Moreover, our results showed that IL-17A induced epithelial-mesenchymal transition (EMT) and promoted HCC cell colonization in vitro and in vivo, and the role of IL-17A in invasion-metastasis was dependent on activation of the AKT pathway...
April 24, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29689568/upregulation-of-trem2-ameliorates-neuroinflammatory-responses-and-improves-cognitive-deficits-triggered-by-surgical-trauma-in-appswe-ps1de9-mice
#20
Yanhua Jiang, Zhe Li, Hong Ma, Xuezhao Cao, Fang Liu, Ayong Tian, Xijia Sun, Xiaoqian Li, Jun Wang
BACKGROUND/AIMS: TREM2 plays a crucial role in modulating microglial function through interaction with DAP12, the adapter for TREM2. Emerging evidence has demonstrated that TREM2 could suppress neuroinflammatory responses by repression of microglia-mediated cytokine production. This study investigated the potential role of TREM2 in surgery-induced cognitive deficits and neuroinflammatory responses in wild-type (WT) and APPswe/PS1dE9 mice. METHODS: Adult APPswe/PS1dE9 transgenic male mice (a classic transgenic model of Alzheimer's disease, 3 months old) and their age-matched WT mice received intracerebral lentiviral particles encoding the mouse TREM2 gene and then were subjected to partial hepatectomy at 1 month after the lentiviral particle injection...
April 18, 2018: Cellular Physiology and Biochemistry
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