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https://www.readbyqxmd.com/read/29232407/temporal-changes-in-cardiac-oxidative-stress-inflammation-and-remodeling-induced-by-exercise-in-hypertension-role-for-local-angiotensin-ii-reduction
#1
Sebastião D Silva, Zaira P Jara, Roseli Peres, Larissa S Lima, Cristóforo Scavone, Augusto C Montezano, Rhian M Touyz, Dulce E Casarini, Lisete C Michelini
Exercise training reduces renin-angiotensin system (RAS) activation, decreases plasma and tissue oxidative stress and inflammation in hypertension. However, the temporal nature of these phenomena in response to exercise is unknown. We sought to determine in spontaneously hypertensive rats (SHR) and age-matched WKY controls the weekly effects of training on blood pressure (BP), plasma and left ventricle (LV) Ang II and Ang-(1-7) content (HPLC), LV oxidative stress (DHE staining), gene and protein expression (qPCR and WB) of pro-inflammatory cytokines, antioxidant enzymes and their consequence on hypertension-induced cardiac remodeling...
2017: PloS One
https://www.readbyqxmd.com/read/29232399/maternal-white-blood-cell-count-cannot-identify-the-presence-of-microbial-invasion-of-the-amniotic-cavity-or-intra-amniotic-inflammation-in-women-with-preterm-prelabor-rupture-of-membranes
#2
Ivana Musilova, Lenka Pliskova, Romana Gerychova, Petr Janku, Ondrej Simetka, Petr Matlak, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: The main aim of this study was to determine the relationship between the maternal white blood cell (WBC) count at the time of hospital admission in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI). The second aim was to test WBC diagnostic indices with respect to the presence of MIAC and/or IAI. METHODS: Four hundred and seventy-nine women with singleton pregnancies complicated by PPROM, between February 2012 and June 2017, were included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29232398/remote-ischemic-preconditioning-attenuates-cardiopulmonary-bypass-induced-lung-injury
#3
Xiaona Zhou, Runzhu Jiang, Yucai Dong, Lifeng Wang
The use of cardiopulmonary bypass (CPB) in cardiac surgeries is known to induce pathological changes in vital organs such as lungs. Remote ischemic preconditioning (RIPC) is a protective strategy that has shown to be able to reduce tissue damage related to ischemia-reperfusion injury (IRI). The current study seeks to evaluate the beneficial effects of limb RIPC on lung tissues and function in a rat CPB model. RIPC, which consisted of three cycles of 5-min ischemia and subsequently 5-min reperfusion, was induced in the hind limbs of the animals via a tourniquet...
2017: PloS One
https://www.readbyqxmd.com/read/29232321/elevated-interleukin-1%C3%AE-and-interleukin-6-levels-in-the-serum-of-children-with-hyperuricemia
#4
Yazhen Di, Jiapei Wang, Yuanling Chen, Nan Sun, Ling Wu, Xiahua Dai, Mengjiao Shen, Qianqian Ying, Shiwei Fu
PURPOSES: The aim of this study was to investigate the serum levels and clinical significance of interleukin 1β (IL-1β) and IL-6 in children with hyperuricemia (HUA). METHODS: We included 71 children with HUA and 71 children with no HUA as control subjects. Children with HUA were divided into groups I and II according to whether they had a history of acute gout-like attacks (including sudden monoarthritis of rapid onset with intense pain and swelling). Group I was examined twice (A, in the acute phase; B, in the remission phase)...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29232287/the-effects-of-known-cardioprotective-drugs-on-proinflammatory-cytokine-secretion-from-human-coronary-artery-endothelial-cells
#5
Michael J Haas, Marilu Jurado-Flores, Ramadan Hammoud, Victoria Feng, Krista Gonzales, Luisa Onstead-Haas, Arshag D Mooradian
BACKGROUND: Endothelial cell dysfunction in diabetes is involved in the pathogenesis and progression of premature atherosclerosis. High-dextrose has been shown to induce both oxidative stress and endoplasmic reticulum stress in cultured human coronary artery endothelial cells (HCAEC). STUDY QUESTION: To determine whether or not several classes of cardioprotective drugs inhibit proinflammatory cytokine expression by HCAEC. MEASURES AND OUTCOMES: To determine the effects of high dextrose on expression of proinflammatory cytokines by HCAEC, cells were treated with either 5...
November 27, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29231777/de-novo-transcriptome-study-identifies-candidate-genes-involved-in-resistance-to-austropuccinia-psidii-myrtle-rust-in-syzygium-luehmannnii-riberry
#6
Peri Ann Tobias, David Guest, Carsten Külheim, Robert F Park
Austropuccinia psidii, causal agent of myrtle rust, was discovered in Australia in 2010 and has since become established on a wide range of species within the Myrtaceae. Syzygium luehmannii, endemic to Australia, is an increasingly valuable berry crop. Plants were screened for responses to A. psidii inoculation and specific resistance, in the form of localised necrosis, was determined in 29% of individuals. To understand the molecular basis underlying this response, mRNA was sequenced from leaf samples taken pre-inoculation, and at 24 and 48 hours post inoculation, from four resistant and four susceptible plants...
December 12, 2017: Phytopathology
https://www.readbyqxmd.com/read/29231709/chemoselective-dual-and-triple-labelling-of-native-and-recombinant-proteins
#7
Bikram Keshari Agrawalla, Tao Wang, Andreas Riegger, Matthias P Domogalla, Kerstin Steinbrink, Thilo Dörfler, Xi Chen, Felix Boldt, Markus Lamla, Jens Michaelis, Seah Ling Kuan, Tanja Weil
The attachment of two or more different functionalities in a site-selective fashion represents a great challenge in protein chemistry. We report multiple functionalization of peptides and proteins capitalizing on reactivity differences of cysteines in their free (thiol) and protected, oxidized (disulfide) forms. The dual and triple functionalization of interleukin 2 and EYFP proceeded with no loss of bio-activity in a stepwise fashion applying maleimide and disulfide rebridging allyl-sulfone groups. In order to ensure broader applicability of the functionalization strategy, a novel, short peptide sequence that introduces a disulfide bridge was designed and site-selective triple labelling in the presence of biogenic groups was successfully demonstrated...
December 12, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29231065/serum-interleukin-6-levels-as-an-indicator-of-aseptic-meningitis-among-children-with-enterovirus-71-induced-hand-foot-and-mouth-disease
#8
Joo Young Lee, Minji Son, Jin Han Kang, Ui Yoon Choi
OBJECTIVES: The enterovirus EV71 is a major pathogen of hand, foot, and mouth disease (HFMD) in children. Aseptic meningitis is the most common neurologic complication of EV71-induced HFMD. Lumbar puncture is a crucial procedure in the diagnosis of aseptic meningitis. It is often performed based on physicians' clinical suspicion. A diagnostic method that can aid in deciding whether this procedure should be performed is necessary. Cytokines are speculated to be associated with neurologic complications...
December 12, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29230639/conserved-peptides-enhance-immune-efficiency-of-inactive-vaccines-against-emerging-avian-influenza-viruses-in-chicken
#9
Jin Xiao, Lei Zhang, Zhenbao Wang, Wangzhen Xiang, Ping Lu, Yingze Zhao, Min Han, Airong Ma, Peng Qi, Ming Wang, George F Gao, William J Liu
Avian influenza viruses (AIVs) such as H5N1 and H7N9 are a great threat to poultry economics and public health. Vaccination can effectively inhibit the spread of AIV in poultry, which is also a viable strategy for controlling virus transmission from poultry to human. Adjuvants that are commonly used in current inactivated vaccines to provide stronger anti-AIV immune responses are often limited in their capacity to quantitatively induce both humoral and cellular immune responses. Herein, we assessed the levels of immune responses generated by a vaccine formulation comprising inactivated H5N1 antigen and synthetic peptides covering conserved CD4+, CD8+ T cell, and B cell epitopes...
September 8, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29230477/interleukin-1-inhibitors-and-dacryoadenitis-in-adult-onset-still-disease
#10
Paul Breillat, Maylis Tourte, Pierre Romero, Gilles Hayem, Ilaria Padovano, Félicie Costantino, Maxime Breban
No abstract text is available yet for this article.
December 12, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29230269/extracellular-vesicles-from-adipose-derived-mesenchymal-stem-cells-downregulate-senescence-features-in-osteoarthritic-osteoblasts
#11
Miguel Tofiño-Vian, Maria Isabel Guillén, María Dolores Pérez Del Caz, Miguel Angel Castejón, Maria José Alcaraz
Osteoarthritis (OA) affects all articular tissues leading to pain and disability. The dysregulation of bone metabolism may contribute to the progression of this condition. Adipose-derived mesenchymal stem cells (ASC) are attractive candidates in the search of novel strategies for OA treatment and exert anti-inflammatory and cytoprotective effects on cartilage. Chronic inflammation in OA is a relevant factor in the development of cellular senescence and joint degradation. In this study, we extend our previous observations of ASC paracrine effects to study the influence of conditioned medium and extracellular vesicles from ASC on senescence induced by inflammatory stress in OA osteoblasts...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29230065/the-toll-like-receptor-2-6-agonist-fsl-1-lipopeptide-therapeutically-mitigates-acute-radiation-syndrome
#12
Cathryn J Kurkjian, Hao Guo, Nathan D Montgomery, Ning Cheng, Hong Yuan, Joseph R Merrill, Gregory D Sempowski, W June Brickey, Jenny P-Y Ting
Risks of radiation exposure from nuclear incidents and cancer radiotherapy are undeniable realities. These dangers urgently compel the development of agents for ameliorating radiation-induced injuries. Biologic pathways mediated by myeloid differentiation primary response gene 88 (MyD88), the common adaptor for toll-like receptor (TLR) and Interleukin-1 receptor signaling, are critical for radioprotection. Treating with agonists prior to radiation enhances survival by activating TLR signaling, whereas radiomitigating TLR-activating therapeutics given after exposure are less defined...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229994/autophagy-induced-during-apoptosis-degrades-mitochondria-and-inhibits-type-i-interferon-secretion
#13
Lisa M Lindqvist, Daniel Frank, Kate McArthur, Toby A Dite, Michael Lazarou, Jonathan S Oakhill, Benjamin T Kile, David L Vaux
Cells undergoing Bax/Bak-mediated apoptosis exhibit signs of autophagy, but how it is activated and its significance is unknown. By directly activating Bax/Bak with BH3-only proteins or BH3 mimetic compounds, we demonstrate that mitochondrial damage correlated with a rapid increase in intracellular [AMP]/[ATP], phosphorylation of 5' AMP-activated protein kinase (AMPK), and activation of unc-51 like autophagy activating kinase 1 (ULK1). Consequently, autophagic flux was triggered early in the apoptotic pathway, as activation of the apoptosome and caspases were not necessary for its induction...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29229953/dual-specificity-phosphatase-5-acts-as-an-anti-inflammatory-regulator-by-inhibiting-the-erk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#14
Huiyun Seo, Young-Chang Cho, Anna Ju, Sewoong Lee, Byoung Chul Park, Sung Goo Park, Jeong-Hoon Kim, Kwonseop Kim, Sayeon Cho
Although dual-specificity phosphatase 5 (DUSP5), which inactivates extracellular signal-regulated kinase (ERK), suppresses tumors in several types of cancer, its functional roles remain largely unknown. Here, we show that DUSP5 is induced during lipopolysaccharide (LPS)-mediated inflammation and inhibits nuclear factor-κB (NF-κB) activity. DUSP5 mRNA and protein expression increased transiently in LPS-stimulated RAW 264.7 cells and then returned to basal levels. DUSP5 overexpression in RAW 264.7 cells suppressed the production of pro-inflammatory tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), whereas knockdown of DUSP5 increased their expression...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229533/xanthoceraside-attenuates-amyloid-%C3%AE-peptide1-42-induced-memory-impairments-by-reducing-neuroinflammatory-responses-in-mice
#15
Yue Qi, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Qian Xu, Qing Jiao, Li-Hua Wang, Li-Bo Zou
Xanthoceraside, a novel triterpenoid saponin extracted from the husks of Xanthoceras sorbifolia Bunge, has neuroprotective effects in vivo and anti-inflammatory properties in vitro. However, the exact mechanism of xanthoceraside on anti-amyloid beta (Aβ)-induced neuroinflammatory responses has not been elucidated. Therefore, we used intracerebroventricular injection of amyloid 1-42 (Aβ1-42) to establish a mouse model to test the effects of xanthoceraside on Aβ-induced cognitive impairments and the TLR2/NF-κB and MAPK pathways...
December 8, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29229532/inflammation-and-renal-fibrosis-recent-developments-on-key-signaling-molecules-as-potential-therapeutic-targets
#16
REVIEW
Wenshan Lv, George W Booz, Yangang Wang, Fan Fan, Richard J Roman
Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal fibrosis is the final common pathway of progressive kidney disease irrespective of the initial injury. Considerable evidence now indicates that renal inflammation plays a central role in the initiation and progression of CKD. Some of the inflammatory signaling molecules involved in CKD include: monocyte chemoattractant protein-1 (MCP-1), bradykinin B1 receptor (B1R), nuclear factor κB (NF-κB), tumor necrosis factor-α (TNFα), transforming growth factor β (TGF-β), and platelet-derived growth factor (PDGF)...
December 8, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29229442/quantitative-analysis-of-tnf-%C3%AE-il-4-and-il-10-expression-nitric-oxide-response-and-apoptosis-in-encephalitozoon-cuniculi-infected-rabbits
#17
Alicia M Nevárez-Garza, Uziel Castillo-Velázquez, Adolfo Soto-Domínguez, R Montes-de-Oca-Luna, Diana E Zamora-Ávila, Alfredo Wong-González, Luis E Rodríguez-Tovar
The expression of tumor necrosis factor (TNF) -α, interleukin (IL) -4 and IL-10, as well as apoptosis and nitric oxide (NO) levels were measured in the brain and kidneys of immunocompetent and immunosuppressed New Zealand White rabbits infected with Encephalitozoon cuniculi. All of the animals had clinical signs histopathological lesions compatible with encephalitozoonosis and were E. cuniculi-positive by using a carbon immunoassay test. Encephalitozoon cuniculi infection promoted the expression of TNF-α and NO production in the kidneys of infected rabbits, and a synergic effect was observed in animal treated with dexamethasone...
December 8, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29229383/short-term-culture-with-il-2-is-beneficial-for-potent-memory-chimeric-antigen-receptor-t-cell-production
#18
Xuhua Zhang, Xiaodong Lv, Yongping Song
Interleukin-2 (IL-2) has been extensively used to boost the body's immune cells, especially T cells. IL-2 is a cytokine that for many years was used to activate and amplify T cells. Due to its potent T cell growth-inducing functions in vitro, for many years, IL-2 was used for the culture and expansion of various T cell products, including tumor-infiltrating lymphocytes (TIL), T cell receptors T cells (TCRT), or genetically engineered cells with chimeric antigen receptors T cells (CAR T). Despite its positive effect on T cell production, the side-effect is not well studied...
December 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29229313/emerging-role-of-adipocytokines-in-type-2-diabetes-as-mediators-of-insulin-resistance-and-cardiovascular-disease
#19
REVIEW
Ravindran Jaganathan, Rajeswari Ravindran, Sugapriya Dhanasekaran
Adipose tissue is an enormously active endocrine organ, secreting various hormones, such as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). All these adipocytokines plays significant roles in the regulation of energy metabolism, glucose and lipid metabolism, reproduction, cardiovascular function and immunity. Adipocytokines are significantly regulated by nutritional status and can directly influence other organ systems, including brain, liver and skeletal muscle...
December 8, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29229189/immunoproteasome-inhibition-prevents-chronic-antibody-mediated-allograft-rejection-in-renal%C3%A2-transplantation
#20
Jun Li, Michael Basler, Gerardo Alvarez, Thomas Brunner, Christopher J Kirk, Marcus Groettrup
Chronic antibody-mediated rejection is the major cause of fading allograft function and loss after renal transplantation. Currently, pharmacological agents for the suppression of chronic antibody-mediated rejection are lacking. Non-selective proteasome inhibitors suppress antibody-mediated allograft rejection. However, extensive adverse side effects of these inhibitors severely limit their application. In contrast, immunoproteasome inhibition is effective in preclinical models of autoimmune diseases and was applied over weeks without obvious adverse side effects...
December 4, 2017: Kidney International
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