Zerin Alimajstorovic, James L Mitchell, Andreas Yiangou, Thomas Hancox, Andrew D Southam, Olivia Grech, Ryan Ottridge, Catherine L Winder, Abd A Tahrani, Tricia M Tan, Susan P Mollan, Warwick B Dunn, Alexandra J Sinclair
Idiopathic intracranial hypertension, a disease classically occurring in women with obesity, is characterized by raised intracranial pressure. Weight loss leads to the reduction in intracranial pressure. Additionally, pharmacological glucagon-like peptide-1 agonism reduces cerebrospinal fluid secretion and intracranial pressure. The potential mechanisms by which weight loss reduces intracranial pressure are unknown and were the focus of this study. Meal stimulation tests (fasted plasma sample, then samples at 15, 30, 60, 90 and 120 min following a standardized meal) were conducted pre- and post-bariatric surgery [early (2 weeks) and late (12 months)] in patients with active idiopathic intracranial hypertension...
2023: Brain communications