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Pseudotumor cerebri

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https://www.readbyqxmd.com/read/29658205/reduced-suprathreshold-odor-identification-in-patients-with-pseudotumor-cerebri-a-non-randomized-prospective-study
#1
Gad Dotan, Eyal Cohen, Ainat Klein, Anat Kesler
BACKGROUND: Recent evidence suggests that olfaction is impaired in patients with pseudotumor cerebri (PTC). OBJECTIVES: To measure suprathreshold olfactory function by using the University of Pennsylvania Smell Identification Test (UPSIT), assessing its usefulness for routine clinical use. METHODS: Forty PTC patients underwent USPIT olfactory testing. RESULTS: Twenty-nine out of 40 (73%) PTC patients (36 women, 4 men; mean age 34 years) had reduced suprathreshold smell sensation according to UPSIT scores: 19 (47%) had mild microsmia, 9 (23%) had moderate microsmia, and one (3%) was classified as having severe microsmia...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29602888/pseudotumor-cerebri-as-the-presentation-of-lyme-disease-in-a-non-endemic-area
#2
Marta Ezequiel, Ana Teresa Teixeira, Maria João Brito, Catarina Luís
Intracranial hypertension is a rare entity in prepubertal children, and its differential diagnosis includes a number of systemic diseases, drugs, vitamin deficiencies and excesses, and hereditary conditions. Infectious aetiology is rare. The case of a 9-year-old boy with intracranial hypertension secondary to acute neuroborreliosis is described. He presented with daily pulsatile frontotemporal headache, pallor, photophobia and phonophobia. His neurological examination revealed papilledema with no nuchal rigidity...
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29565728/optic-nerve-sheath-fenestration-a-revised-lateral-approach-for-nerve-access
#3
Nathan W Blessing, David T Tse
Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, describes a disease of poorly understood pathophysiology with a specific set of signs and symptoms including potentially irreversible and blinding visual loss. Optic nerve sheath fenestration (ONSF) is a well-described surgical treatment for patients with IIH and progressive visual loss despite maximally tolerated medical therapy. A number of optic nerve access procedures have been described including medial transconjunctival, superomedial lid crease, and lateral orbitotomy with and without bone takedown...
March 22, 2018: Orbit
https://www.readbyqxmd.com/read/29519994/laparoscopy-in-the-management-of-lumboperitoneal-shunt-catheter-in-obese-patients-with-pseudotumor-cerebri
#4
S Ozturk, H Cakin, K Karabulut, R Pasahan, M Kaplan
Lumboperitoneal shunts are widely used for the treatment of patients diagnosed with pseudotumor cerebri (PTC). Obesity is a risk factor for PTC. In particular, catheter migration out of the abdominal cavity is more commonly observed in morbidly obese patients. The aim of this study was to discuss the underlying mechanisms of catheter migration and treatment modalities in morbidly obese patients with PTC. The present study included four morbidly obese patients. All cases had undergone the previous laparotomy for insertion of a distal catheter into the abdominal cavity...
March 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29459315/magnetic-resonance-elastography-to-estimate-brain-stiffness-measurement-reproducibility-and-its-estimate-in-pseudotumor-cerebri-patients
#5
Arunark Kolipaka, Peter A Wassenaar, Sangmin Cha, Wael M Marashdeh, Xiaokui Mo, Prateek Kalra, Bradley Gans, Brian Raterman, Eric Bourekas
This study determines the reproducibility of magnetic resonance elastography (MRE) derived brain stiffness in normal volunteers and compares it against pseudotumor patients before and after lumbar puncture (LP). MRE was performed on 10 normal volunteers for reproducibility and 14 pseudotumor patients before and after LP. During LP, opening and closing cerebrospinal fluid (CSF) pressures were recorded before and after removal of CSF and correlated to brain stiffness. Stiffness reproducibility was observed (r > 0...
February 11, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29413638/evidence-of-diplopia-in-children-s-headache-drawings-helps-to-differentiate-pseudotumor-cerebri-from-migraine
#6
Erica B Lee, Fredrick S Edelman, Carl E Stafstrom
OBJECTIVE: This study aimed to determine whether children's headache drawings can distinguish between pseudotumor cerebri and migraine. BACKGROUND: Headache features associated with pseudotumor cerebri (pseudotumor; idiopathic intracranial hypertension) are nonspecific and are difficult to distinguish clinically from migraines. Children's headache drawings have a high predictive value for migraine versus nonmigraine headaches. We hypothesized that drawings could help to differentiate pediatric headaches due to pseudotumor cerebri from those associated with migraines...
February 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29393752/treatment-of-idiopathic-intracranial-hypertension-via-stereotactic-placement-of-biventriculoperitoneal-shunts
#7
Michael Karsy, Hussam Abou-Al-Shaar, Christian A Bowers, Richard H Schmidt
OBJECTIVE Idiopathic intracranial hypertension (IIH), or pseudotumor cerebri, is a complex and difficult-to-manage condition that can lead to permanent vision loss and refractory headaches if untreated. Traditional treatment options, such as unilateral ventriculoperitoneal (VP) or lumboperitoneal (LP) shunt placement, have high complication and failure rates and often require multiple revisions. The use of bilateral proximal catheters has been hypothesized as a method to improve shunt survival. The use of stereotactic technology has improved the accuracy of catheter placement and may improve treatment of IIH, with fewer complications and greater shunt patency time...
February 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29375948/vestibular-schwannoma-presenting-with-bilateral-papilledema-without-hydrocephalus-case-study
#8
Carlos Candanedo, Samuel Moscovici, Joshua M Kruger, Cezar J Mizrachi, Ruth Eliahou, Sergey Spektor
Bilateral papilledema secondary to obstructive or communicating hydrocephalus in patients with vestibular schwannomas is a known presentation; however, papilledema in the absence of hydrocephalus is rarely reported and its mechanism is poorly understood. We report a case of a 20-year-old woman presenting with visual deterioration and bilateral papilledema on fundoscopy. Magnetic resonance imaging (MRI) revealed a giant vestibular schwannoma with no sign of hydrocephalus. The only imaging evidence of increased pressure on preoperative imaging studies was seen on a T2-weighted MRI, where there was subtle dilatation of the arachnoid space of the optic sleeve...
November 20, 2017: Curēus
https://www.readbyqxmd.com/read/29354685/inflammatory-gene-expression-signatures-in-idiopathic-intracranial-hypertension-possible-implications-in-microgravity-induced-icp-elevation
#9
Susana B Zanello, Vasisht Tadigotla, James Hurley, Johan Skog, Brian Stevens, Eusebia Calvillo, Eric Bershad
The visual impairment and intracranial pressure (VIIP) syndrome is a neuro-ophthalmologic condition described in astronauts returning from long duration space missions. Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is characterized by a chronic elevation of intracranial pressure (ICP) in the absence of an intracranial mass lesion. Because VIIP and IIH share some neurologic and ophthalmologic manifestations, the latter might be used as a model to study some of the processes underlying VIIP...
2018: NPJ Microgravity
https://www.readbyqxmd.com/read/29344065/optociliary-shunt-vessels-role-in-diagnosis-and-treatment-of-atypical-pseudotumor-cerebri
#10
Frederico Castelo Moura, Ida Fortini
A 46-year-old man presented with severe visual loss and optic atrophy associated with optociliary shunt vessels. The diagnostic work-up revealed intracranial hypertension and cerebral venous sinus stenosis, with no evidence of previous thrombosis. In view of the severe visual dysfunction, both eyes were submitted to optic nerve sheath fenestration. After surgery, a regression of collateral vessels was observed in both eyes.
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344058/an-estimation-of-the-risk-of-pseudotumor-cerebri-among-users-of-the-levonorgestrel-intrauterine-device
#11
Reuben M Valenzuela, Ruju Rai, Brian H Kirk, Jessica N Sanders, Subhashree Sundar, Steffen Hamann, Judith E A Warner, Kathleen B Digre, Alison V Crum, Kirtly P Jones, Bradley J Katz
Because of a previous association of pseudotumor cerebri (PTC) with levonorgestrel, we wished to evaluate the use of levonorgestrel-eluting intrauterine devices ("levonorgestrel intrauterine systems", LNG-IUS) in our University of Utah and Rigshospitalet PTC patients. In our retrospective series, PTC prevalence was approximately 0.18% and 0.15% in the LNG-IUS population versus 0.02% and 0.04% in the non-LNG-IUS population (Utah and Rigshospitalet, respectively), with no significant differences in PTC signs and symptoms among the two groups...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29333792/reduced-suprathreshold-odor-identification-in-patients-with-pseudotumor-cerebri-a-non-randomized-prospective-study
#12
Gad Dotan, Eyal Cohen, Ainat Klein, Anat Kesler
BACKGROUND: Recent evidence suggests that olfaction is impaired in patients with pseudotumor cerebri (PTC). OBJECTIVES: To measure suprathreshold olfactory function by using the University of Pennsylvania Smell Identification Test (UPSIT), assessing its usefulness for routine clinical use. METHODS: Forty PTC patients underwent USPIT olfactory testing. RESULTS: Twenty-nine out of 40 (73%) PTC patients (36 women, 4 men; mean age 34 years) had reduced suprathreshold smell sensation according to UPSIT scores: 19 (47%) had mild microsmia, 9 (23%) had moderate microsmia, and one (3%) was classified as having severe microsmia...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29328996/acute-and-sub-acute-neurological-toxicity-in-children-treated-for-acute-lymphoblastic-leukemia
#13
REVIEW
Natalia C Millan, Analía Pastrana, Myriam R Guitter, Pedro A Zubizarreta, María S Monges, María S Felice
Eighty percent of children with acute lymphoblastic leukemia (ALL) survive with current treatments. Neurotoxicity is an infrequent adverse event. We describe clinical presentations of neurological toxicity, phases of treatment when these adverse events were more frequent and patients ́ outcome. From January-1995 to December-2015, 1379 ALL cases were admitted. Neurotoxicity was diagnosed in 49 patients (3.6%) and classified according to neurological syndromes. Medical records, laboratory-tests and images were reviewed...
February 2018: Leukemia Research
https://www.readbyqxmd.com/read/29326535/very-rare-presentation-of-cerebrovascular-accident-in-20-year-old-man-with-familial-mediterranean-fever-case-report
#14
Miramir Aghdashi, Seyed-Mostafa Seidmardani, Sara Vossoughian, Seyed Arman Seyed Mokhtari
Familial Mediterranean fever (FMF) is characterized by recurrent episodes of fever accompanied by serosal, synovial, or cutaneous inflammation. The central nervous system (CNS) is rarely involved in FMF. The CNS involvement includes demyelinating lesions, posterior reversible encephalopathy syndrome, pseudotumor cerebri, optic neuritis, and cerebral vasculitis. Here, we present a 20-year-old man, a known case of FMF with abrupt left-sided hemiparesis. Brain magnetic resonance imaging revealed right periventricular infarction...
2018: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/29243006/ocular-ultrasound-for-monitoring-pseudotumor-cerebri-syndrome
#15
Piergiorgio Lochner, Klaus Fassbender, Martin Lesmeister, Raffaele Nardone, Andrea Orioli, Francesco Brigo, Erwin Stolz
The aim of this study was to evaluate the feasibility of ocular ultrasound in the follow-up of pseudotumor cerebri syndrome and to correlate ultrasound with clinical parameters. In a cohort study of 22 consecutive adult patients, ocular ultrasound was performed measuring optic nerve sheath diameter, optic nerve diameter, and optic disc elevation compared with symptoms referred by the patients. The patients showed increased optic nerve sheath diameter [median, 6.51 mm (interquartile range 6.13-7.10)], optic nerve diameter [3...
February 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29230542/secondary-intracranial-hypertension-pseudotumor-cerebri-presenting-as-post-traumatic-headache-in-mild-traumatic-brain-injury-a-case-series
#16
Tonia Sabo, Charlene Supnet, Sushmita Purkayastha
BACKGROUND: Cerebral edema peaks 36-72 h after moderate traumatic brain injury but thought to be uncommon after mild traumatic brain injury. Post-traumatic headache can develop 48-72 h post-injury, perhaps reflecting the developing cerebral edema. Pseudotumor cerebri can result from various causes, including cerebral edema, and is characterized by increased intracranial pressure, headache, visual, and other common symptoms. Our objective was to report a phenotypically identifiable post-traumatic headache subtype...
December 11, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29218128/neurobrucellosis-presenting-as-pseudotumor-cerebri-first-report-from-oman
#17
Padam P Sharma, Mangudi V Murali, Tahsin Hamdi
A ten-year-old boy presented to the hospital with body ache and joint pains for two months and headache, vomiting, and skin rash for three days. He was drowsy and lethargic at admission. Physical examination revealed bilateral papilledema. There were no cranial nerve involvement, neuromotor deficit, or signs of meningeal irritation. Computed tomography and magnetic resonance imaging of the brain did not reveal any evidence of cerebral edema or space occupying lesion. In view of the high endemicity of brucellosis in the area, Brucella agglutination test (BAT) was done at the time of admission and was negative...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29195824/pseudotumor-cerebri-syndrome-in-a-patient-with-narcolepsy-type-1
#18
Thomas Rossor, Ming Lim, Kirandeep VanDenEshof, Paul Gringras
Type 1 narcolepsy (NT1) is a chronic primary disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucinations and disrupted nocturnal sleep. NT1 is linked to hypothalamic hypocretin deficiency, strongly associated with Human Leukocyte Antigen (HLA) marker DQB1*06:02 and of probable autoimmune origin. NT1 is usually associated with increased rates of overweight and obesity, and sometimes with increases in overnight blood pressure and increased rates of hypoventilation with raised CO2 levels overnight...
January 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29194601/idiopathic-intracranial-hypertension-in-children-and-adolescents-an-update
#19
Catalina Cleves-Bayon
PREMISE: Idiopathic intracranial hypertension (IIH), previously known as pseudotumor cerebri syndrome (PTC) is a serious neurological disorder that can lead to irreversible visual loss. Predominantly a disorder affecting women in reproductive years, the pediatric population is not spared. PROBLEM: In the past few years, the condition has been redefined, due to new accepted values for opening pressure in children and advances in neuroimaging. Emerging techniques in ophthalmology are being increasingly used to monitor disease in these patients...
March 2018: Headache
https://www.readbyqxmd.com/read/29184272/approach-to-chronic-secondary-headache-a-case-report-on-unusual-drug-side-effects
#20
Hamid Reza Riasi, Forod Salehi, Morteza Hajihosseini
In this article, we present the case of a 12-year-old female child who complained of bilateral temporal and frontal headache for 2 to 3 months with nausea and vomiting. Physical examination revealed right-sided sixth cranial nerve palsy and papilledema in ophthalmoscopy. To find the cause of increased intracranial pressure, the patient underwent brain imaging and brain MRI showed no abnormality. Ultimately, lumbar puncture (LP) was performed and cerebrospinal fluid (CSF) pressure was 280 mmH2 O with normal chemistry...
November 2017: Iranian Journal of Medical Sciences
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