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https://www.readbyqxmd.com/read/28089525/radiotherapeutic-management-of-vestibular-schwannomas-using-size-and-location-adapted-fractionation-regimens-to-maximize-the-therapeutic-ratio
#1
Benjamin G Slane, Uma Goyal, Joel L Grow, Christopher Morrison, Craig R Hullet, John Gordon, Abhay Sanan, Baldassarre Stea
BACKGROUND: We evaluated and compared the radiographic and clinical outcomes of patients with vestibular schwannomas treated with single fraction stereotactic radiosurgery (SRS), 5 fractions of hypofractionated stereotactic radiation therapy (hSRT), or 25 to 30 fractions of conventionally fractionated stereotactic radiation therapy (cfSRT). METHODS AND MATERIALS: Fifty-six patients treated with LINAC-based SRS (median, 12.5 Gy), hSRT (25 Gy), or cfSRT (median, 54 Gy) were retrospectively reviewed...
October 28, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28081010/biological-dose-representation-for-carbon-ion-radiotherapy-of-unconventional-fractionation
#2
Nobuyuki Kanematsu, Taku Inaniwa
In carbon-ion radiotherapy, single-beam delivery each day in alternate directions has been common practice for efficient operation, taking advantage of the Bragg peak and the relative biological effectiveness (RBE) for uniform dose conformation to a tumor. Treatments are usually fractionated and treatment plans are evaluated with the total RBE-weighted dose; however, this is of limited relevance to the biological effect. In this study, we reformulate the biologically effective dose (BED) to normalize the dose-fractionation and cell-repopulation effects as well as the RBE of treating radiation, based on inactivation of a reference cell line by a reference carbon-ion radiation...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28078233/prostate-cancer-and-hypofractionation-really-a-new-standard-of-care
#3
EDITORIAL
Christian Carrie, Ronan Tanguy
No abstract text is available yet for this article.
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28070828/hypofractionated-stereotactic-radiosurgery-for-pituitary-metastases
#4
Haemin Chon, KyoungJun Yoon, Do Hoon Kwon, Chang Jin Kim, Min-Seon Kim, Young Hyun Cho
Pituitary metastases (PMs) are uncommon, representing only 1% of pituitary lesions. The diagnosis of PMs can be challenging and an optimal management remains to be determined. Here, we present a pilot clinical study on the efficacy and safety of hypofractionated stereotactic radiosurgery (SRS) with an optimized dosimetric plan in treating PMs. Between June 2013 and December 2014, seven consecutive patients (4 men and 3 women; median age 62 years) had been diagnosed with PMs based on their characteristic clinical and radiological features and subsequently treated using hypofractionated SRS...
January 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28062087/does-an-integrated-boost-increase-acute-toxicity-in-prone-hypofractionated-breast-irradiation-a-randomized-controlled-trial
#5
Leen Paelinck, Akos Gulyban, Ferenc Lakosi, Tom Vercauteren, Werner De Gersem, Bruno Speleers, Christel Monten, Thomas Mulliez, Patrick Berkovic, Annick van Greveling, Frederik Decoster, Philippe Coucke, Wilfried De Neve, Liv Veldeman
BACKGROUND AND PURPOSE: The safety of a simultaneous integrated boost (SIB) in combination with prone hypofractionated whole-breast irradiation (WBI) was investigated. MATERIALS AND METHODS: 167 patients were randomized between WBI with a sequential boost (SeB) or SIB. All patients were treated in prone position to 40.05Gy in 15 fractions to the whole breast. In the control arm, a SeB of 10Gy in 4 fractions (negative surgical margins) or 14.88Gy in 6 fractions (transsection) was prescribed...
January 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28048927/mo-fg-bra-05-dosimetric-and-radiobiological-validation-of-respiratory-gating-in-conventional-and-hypofractionated-radiotherapy-of-the-lung-effect-of-dose-dose-rate-gating-window-and-breathing-pattern
#6
L Cervino, D Soultan, N Pettersson, A Yock, M Cornell, J Aguilera, J Murphy, B Gill, S Advani, V Moiseenko
PURPOSE: to evaluate the dosimetric and radiobiological consequences from having different gating windows, dose rates, and breathing patterns in gated VMAT lung radiotherapy. METHODS: A novel 3D-printed moving phantom with central high and peripheral low tracer uptake regions was 4D FDG-PET/CT-scanned using ideal, patient-specific regular, and irregular breathing patterns. A scan of the stationary phantom was obtained as a reference. Target volumes corresponding to different uptake regions were delineated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048885/mo-d-brb-03-quality-assurance-of-sbrt
#7
J Roper
: Increased use of SBRT and hypofractionation in radiation oncology practice has posted a number of challenges to medical physicist, ranging from planning, image-guided patient setup and on-treatment monitoring, to quality assurance (QA) and dose delivery. This symposium is designed to provide current knowledge necessary for the safe and efficient implementation of SBRT in various linac platforms, including the emerging digital linacs equipped with high dose rate FFF beams. Issues related to 4D CT, PET and MRI simulations, 3D/4D CBCT guided patient setup, real-time image guidance during SBRT dose delivery using gated/un-gated VMAT/IMRT, and technical advancements in QA of SBRT (in particular, strategies dealing with high dose rate FFF beams) will be addressed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048766/su-g-bra-16-target-dose-comparison-for-dynamic-mlc-tracking-and-mid-ventilation-planning-in-lung-radiotherapy-subject-to-intrafractional-baseline-drifts
#8
M J Menten, M F Fast, S Nill, U Oelfke
PURPOSE: Lung tumor motion during radiotherapy can be accounted for by expanded treatment margins, for example using a mid-ventilation planning approach, or by localizing the tumor in real-time and adapting the treatment beam with multileaf collimator (MLC) tracking. This study evaluates the effect of intrafractional changes in the average tumor position (baseline drifts) on these two treatment techniques. METHODS: Lung stereotactic treatment plans (9-beam IMRT, 54Gy/3 fractions, mean treatment time: 9...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048479/we-ab-207b-01-dose-tolerance-for-sbrt-sabr
#9
J Grimm
PURPOSE: Stereotactic body radiation therapy (SBRT) / stereotactic ablative body radiotherapy (SABR) is gaining popularity, but quantitative dose tolerance has still been lacking. To improve this, the April 2016 issue of Seminars in Radiation Oncology will have normal tissue complication probability (NTCP) models for 10 critical structures: optic pathway, cochlea, oral mucosa, esophagus, chestwall, aorta, bronchi, duodenum, small bowel, and spinal cord. METHODS: The project included more than 1500 treatments in 1-5 fractions using CyberKnife, Gamma Knife, or LINAC, with 60 authors from 15 institutions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048423/we-fg-bra-08-potential-role-of-the-glycolytic-oscillator-in-acute-hypoxia-in-tumors
#10
L Che Fru, E Adamson, D Campos, S Fain, S Jacques, A van der Kogel, K Nickel, C Song, R Kimple, M Kissick
PURPOSE: Oscillatory dynamics in acute hypoxia have been observed, but poorly understood. They have mostly been attributed to vascular perturbations, but no link has yet been made to metabolic causes. We set out to determine the fundamental frequencies and test for coherence in tumor oxygen dynamics and spatial properties. METHODS: Severe combined immunodeficient (SCID) mice were inoculated onto bilateral flanks with human derived head and neck carcinoma (UW-SCC22) cell line xenografts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048360/mo-b-201-03-mri-guided-tracking-and-gating
#11
O Green
: The motion management in stereotactic body radiation therapy (SBRT) is a key to success for a SBRT program, and still an on-going challenging task. A major factor is that moving structures behave differently than standing structures when examined by imaging modalities, and thus require special considerations and employments. Understanding the motion effects to these different imaging processes is a prerequisite for a decent motion management program. The commonly used motion control techniques to physically restrict tumor motion, if adopted correctly, effectively increase the conformity and accuracy of hypofractionated treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048243/mo-b-201-00-motion-management-in-current-stereotactic-body-radiation-therapy-sbrt-practice
#12
Charles Shang
: The motion management in stereotactic body radiation therapy (SBRT) is a key to success for a SBRT program, and still an on-going challenging task. A major factor is that moving structures behave differently than standing structures when examined by imaging modalities, and thus require special considerations and employments. Understanding the motion effects to these different imaging processes is a prerequisite for a decent motion management program. The commonly used motion control techniques to physically restrict tumor motion, if adopted correctly, effectively increase the conformity and accuracy of hypofractionated treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048164/su-f-j-124-reduction-in-dosimetric-impact-of-motion-using-vmat-compared-to-imrt-in-hypofractionated-prostate-cancer-patients
#13
B Ravindranath, J Xiong, L Happersett, G Mageras, P Zhang, M Hunt
PURPOSE: To quantify and compare the dosimetric impact of motion management correction strategies during VMAT and IMRT for hypofractionated prostate treatment. METHODS: Two arc VMAT and 9 field IMRT plans were generated for two prostate cancer patients undergoing hypofractionated radiotherapy (7.5Gy × 5 and 8Gy × 5). 212 motion traces were retrospectively extracted from treatment records of prostate cancer patients with implanted Calypso beacons. Dose to the CTV and normal tissues was reconstructed for each trace and plan taking into account the actual treatment delivery time...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048140/mo-fg-campus-jep2-05-mri-guided-single-fraction-boost-delivery-on-individual-axillary-lymph-nodes
#14
T C F van Heijst, N Hoekstra, M E P Philippens, D Eschbach, J J W Lagendijk, H J G D van den Bongard, B van Asselen
PURPOSE: The Utrecht MRI-linac (MRL) design enables new MR-guided radiotherapy (RT) approaches. This is a feasibility study for a single-fraction high dose (boost) to individual lymph nodes (LNs) in breast-cancer patients, after breast-conserving surgery (BCS) and hypofractionated whole-breast irradiation (WBI) with conventional axillary RT (AxRT). METHODS: After written informed consent, 5 breast-cancer patients (cT1-3N0) were enrolled (NL500460.041.14 trial) and underwent 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048128/mo-d-brb-00-sbrt-workflow-overview
#15
Lei Xing
: Increased use of SBRT and hypofractionation in radiation oncology practice has posted a number of challenges to medical physicist, ranging from planning, image-guided patient setup and on-treatment monitoring, to quality assurance (QA) and dose delivery. This symposium is designed to provide current knowledge necessary for the safe and efficient implementation of SBRT in various linac platforms, including the emerging digital linacs equipped with high dose rate FFF beams. Issues related to 4D CT, PET and MRI simulations, 3D/4D CBCT guided patient setup, real-time image guidance during SBRT dose delivery using gated/un-gated VMAT/IMRT, and technical advancements in QA of SBRT (in particular, strategies dealing with high dose rate FFF beams) will be addressed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048093/su-f-j-27-segmentation-of-prostate-cbct-images-with-implanted-calypso-transponders-using-double-haar-wavelet-transform
#16
Y Liu, Z Saleh, Y Song, C Obcemea, M Chan, X Li, L Happersett, C Shi, X Qian, X Tang
PURPOSE: Segmentation of prostate CBCT images is an essential step towards real-time adaptive radiotherapy. It is challenging For Calypso patients, as more artifacts are generated by the beacon transponders. We herein propose a novel wavelet-based segmentation algorithm for rectum, bladder, and prostate of CBCT images with implanted Calypso transponders. METHODS: Five hypofractionated prostate patients with daily CBCT were studied. Each patient had 3 Calypso transponder beacons implanted, and the patients were setup and treated with Calypso tracking system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047597/mo-b-201-01-overcoming-the-challenges-of-motion-management-in-current-lung-sbrt-practice
#17
C Shang
: The motion management in stereotactic body radiation therapy (SBRT) is a key to success for a SBRT program, and still an on-going challenging task. A major factor is that moving structures behave differently than standing structures when examined by imaging modalities, and thus require special considerations and employments. Understanding the motion effects to these different imaging processes is a prerequisite for a decent motion management program. The commonly used motion control techniques to physically restrict tumor motion, if adopted correctly, effectively increase the conformity and accuracy of hypofractionated treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047475/mo-d-brb-01-fundamental-aspects-of-sbrt
#18
F Yin
: Increased use of SBRT and hypofractionation in radiation oncology practice has posted a number of challenges to medical physicist, ranging from planning, image-guided patient setup and on-treatment monitoring, to quality assurance (QA) and dose delivery. This symposium is designed to provide current knowledge necessary for the safe and efficient implementation of SBRT in various linac platforms, including the emerging digital linacs equipped with high dose rate FFF beams. Issues related to 4D CT, PET and MRI simulations, 3D/4D CBCT guided patient setup, real-time image guidance during SBRT dose delivery using gated/un-gated VMAT/IMRT, and technical advancements in QA of SBRT (in particular, strategies dealing with high dose rate FFF beams) will be addressed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047290/tu-h-brc-02-biological-dose-escalation-for-liver-sbrt-through-spatiotemporal-fractionation
#19
J Unkelbach, Z Perko, J Wolfgang, T Hong
PURPOSE: Stereotactic body radiotherapy (SBRT) has become an established treatment option for liver cancer. For patients with large tumors, the prescription dose is often limited by constraints on the mean liver dose, leading to tumor recurrence. In this work, we demonstrate that spatiotemporal fractionation schemes, ie delivering distinct dose distributions in different fractions, may allow for a 10% increase in biologically effective dose (BED) in the tumor compared to current practice where each fraction delivers the same dose distribution...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047237/tu-h-campus-tep1-01-variable-beam-fractionation-for-sabr
#20
A Modiri, A Sawant
PURPOSE: In current conventionally-fractionated as well as hypofractionated 3D conformal radiotherapy (CRT), the same beam arrangement is employed from fraction to fraction. We challenge this notion and postulate that by varying the beam arrangement between fractions we can achieve greater sparing of organs at risk (OARs) while maintaining PTV coverage. We use an inverse planning strategy using a swarm intelligence-based global optimization algorithm to exploit the additional degree of freedom represented by inter-fractional variation in beam angles...
June 2016: Medical Physics
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