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Hypofractionation

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https://www.readbyqxmd.com/read/29221876/conventional-versus-hypofractionated-radiation-therapy-for-localized-prostate-cancer-a-meta-analysis-of-randomized-noninferiority-trials
#1
REVIEW
Trevor Joseph Royce, Dong Hoon Lee, NaNa Keum, Nitipong Permpalung, Calvin J Chiew, Sherise Epstein, Kristen M Pluchino, Anthony V D'Amico
CONTEXT: Whether hypofractionated radiation therapy (RT) compared with conventionally fractionated RT provides comparable or possibly improved cancer control without increased toxicity in localized prostate cancer (PC) remains unknown. OBJECTIVE: Realizing from the CHHiP trial that outcomes are highly sensitive to the dose fractionation schedule and number of treatments, we conducted a systematic review and meta-analysis selecting only the randomized noninferiority trials, because the randomized arms closely approximated one another in terms of the dose fractionation schedule, and compared cancer control and toxicity of hypofractionated RT with conventionally fractionated RT for localized PC...
November 4, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29212499/radiotherapy-plus-temozolomide-in-elderly-patients-with-glioblastoma-a-real-life-report
#2
J Biau, E Chautard, E De Schlichting, G Dupic, B Pereira, A Fogli, M Müller-Barthélémy, P Dalloz, T Khalil, A F Dillies, X Durando, C Godfraind, P Verrelle
BACKGROUND: The optimization of the management for elderly glioblastoma patients is crucial given the demographics of aging in many countries. We report the outcomes for a "real-life" patient cohort (i.e. unselected) comprising consecutive glioblastoma patients aged 70 years or more, treated with different radiotherapy +/- temozolomide regimens. METHODS: From 2003 to 2016, 104 patients ≥ 70 years of age, consecutively treated by radiotherapy for glioblastoma, were included in this study...
December 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29209874/utilization-of-hypofractionated-radiotherapy-in-treatment-of-glioblastoma-multiforme-in-elderly-patients-not-receiving-adjuvant-chemoradiotherapy-a-national-cancer-database-analysis
#3
Brian Bingham, Chirayu G Patel, Eric T Shinohara, Albert Attia
To assess the utilization and outcomes of adjuvant monotherapy with hypofractionated radiation (RT) among elderly patients not receiving traditional adjuvant chemoradiotherapy (cRT) for glioblastoma multiforme (GBM). A retrospective analysis using the National Cancer Data Base with GBM patients aged 65 years or older treated between 2005 and 2012 was conducted. Patients who underwent hypofractionated RT (40 Gy), conventional RT (60 Gy), chemotherapy, or best supportive care alone were included. Statistical methods included logistic regression for utilization and Cox regression for survival analysis...
December 5, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29205080/the-potential-benefits-from-respiratory-gating-for-breast-cancer-patients-regarding-target-coverage-and-dose-to-organs-at-risk-when-applying-strict-dose-limits-to-the-heart-results-from-the-dbcg-hypo-trial
#4
Martin Berg, Ebbe L Lorenzen, Ingelise Jensen, Mette S Thomsen, Christina Maria Lutz, Lasse Refsgaard, Henrik D Nissen, Birgitte V Offersen
PURPOSE: The potential benefits from respiratory gating (RG) compared to free-breathing (FB) regarding target coverage and dose to organs at risk for breast cancer patients receiving post-operative radiotherapy (RT) in the DBCG HYPO multicentre trial are reported. MATERIAL AND METHODS: Patients included in the DBCG HYPO trial were randomized between 50 Gy in 25 fractions (normofractionated) versus 40 Gy in 15 fractions (hypofractionated). A tangential forward field-in-field dose planning technique was used to cover the clinical target volume (CTV) with the intent to limit dose to the left anterior descending coronary artery (LADCA) to 20 Gy and 17 Gy in the normo- and hypofractionated arms, respectively...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29203951/hypo-fractionated-radiation-magnetic-nanoparticle-hyperthermia-and-a-viral-immunotherapy-treatment-of-spontaneous-canine-cancer
#5
P Jack Hoopes, Karen L Moodie, Alicia A Petryk, James D Petryk, Shawntel Sechrist, David J Gladstone, Nicole F Steinmetz, Frank A Veliz, Alicea A Bursey, Robert J Wagner, Ashish Rajan, Danielle Dugat, Margaret Crary-Burney, Steven N Fiering
It has recently been shown that cancer treatments such as radiation and hyperthermia, which have conventionally been viewed to have modest immune based anti-cancer effects, may, if used appropriately stimulate a significant and potentially effective local and systemic anti-cancer immune effect (abscopal effect) and improved prognosis. Using eight spontaneous canine cancers (2 oral melanoma, 3 oral amelioblastomas and 1 carcinomas), we have shown that hypofractionated radiation (6 x 6 Gy) and/or magnetic nanoparticle hyperthermia (2 X 43°C / 45 minutes) and/or an immunogenic virus-like nanoparticle (VLP, 2 x 200 μg) are capable of delivering a highly effective cancer treatment that includes an immunogenic component...
January 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29199709/stereotactic-body-radiation-therapy-for-early-stage-primary-lung-cancer-is-an-active-breath-coordinator-necessary-an-audit-from-a-tertiary-cancer-care-center
#6
R Madhavan, P S Renilmon, H M Nair, A Lal, S S Nair, U G Unnikrishnan, D Makuny
CONTEXT: The hypofractionated stereotactic body radiation therapy (SBRT) has emerged as a safe and effective treatment modality for early-stage nonsmall cell lung carcinoma. AIMS: An audit SBRT in primary lung cancer treated in our center with and without an active breath coordinator (ABC) was undertaken to evaluate its impact on target volumes and clinical outcomes. SETTINGS AND DESIGN: This was an observational study. MATERIALS AND METHODS: Nine patients with lung carcinoma were treated from January 2014 to August 2016...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29198408/estimating-the-number-of-fractions-by-tumour-site-for-european-countries-in-2012-and-2025-an-estro-hero-analysis
#7
Josep M Borras, Cai Grau, Julieta Corral, Karen Wong, Michael B Barton, Jacques Ferlay, Freddie Bray, Yolande Lievens
BACKGROUND AND PURPOSE: The optimal number of radiotherapy fractions is a relevant input for planning resource needs. An estimation of the total number of fractions by country and tumour site is assessed for 2012 and 2025. METHODS: European cancer incidence data by tumour site and country for 2012 and 2025 were extracted from the GLOBOCAN database. Incidence and stage data were introduced in the Australian Collaboration for Cancer Outcomes Research and Evaluation (CCORE) model, producing an evidence-based proportion of incident cases with an indication for radiotherapy and fractions by indication...
November 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29194625/laryngeal-chondronecrosis-after-radiation-therapy-in-a-dog
#8
J Bertran, M Martinez, M Breit, M A McLoughlin, K L Ham, E Warry, V Wavreille
A 5-year-old pug presented with a soft tissue swelling on the ventral neck and moderate stridor with associated respiratory effort. This patient received hypofractionated radiotherapy for metastatic upper lip mast cell tumour and to the submandibular lymph nodes 6 months before presentation. Oral examination showed moderate elongation of the soft palate, stage III laryngeal collapse with only the right laryngeal saccule mildly everted and exuberant pale epiglottal and left pharyngeal mucosa. Staphylectomy, resection of the epiglottal mucosa and left arytenoid lateralisation were performed...
November 30, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29190707/hypofractionated-stereotactic-boost-in-intermediate-risk-prostate-carcinoma-preliminary-results-of-a-multicenter-phase-ii-trial-ckno-pro
#9
David Pasquier, Philippe Nickers, Didier Peiffert, Philippe Maingon, Pascal Pommier, Thomas Lacornerie, Geoffrey Martinage, Emmanuelle Tresch, Eric Lartigau
PURPOSE: Dose escalation may improve curability in intermediate-risk prostate carcinoma. A multicenter national program was developed to assess toxicity and tumor response with hypofractionated stereotactic boost after conventional radiotherapy in intermediate-risk prostate cancer. METHODS AND MATERIAL: Between August 2010 and April 2013, 76 patients with intermediated-risk prostate carcinoma were included in the study. A first course delivered 46 Gy by IMRT (68...
2017: PloS One
https://www.readbyqxmd.com/read/29181556/oligometastases-in-prostate-cancer-metabolic-response-in-follow-up-psma-pet-cts-after-hypofractionated-igrt
#10
René Baumann, Mark Koncz, Ulf Luetzen, Fabian Krause, Juergen Dunst
BACKGROUND: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMAPET/CT) is a new and evolving diagnostic method in prostate cancer with special impact on treatment planning in image-guided radiotherapy (IGRT). Initial results of metabolic response in repeated PSMA PET/CTs after hypofractionated IGRT for metastatic lesions are reported here. MATERIALS AND METHODS: Of 280 patients investigated with 68Ga-PSMA PET/CT in the period from 01/2014 through 12/2016 in the authors' department, patients were selected according to the following criteria: oligometastatic disease at initial PSMA PET/CT defined as not more than five metastatic lesions, hypofractionated IGRT to all lesions, no systemic therapy in the last 6 months and during follow-up, and at least one follow-up PSMA PET after radiotherapy...
November 27, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29178983/hypofractionated-radiotherapy-for-prostate-cancer-in-the-postoperative-setting-what-is-the-evidence-so-far
#11
REVIEW
Cristina Picardi, Ioan Perret, Raymond Miralbell, Thomas Zilli
Postoperative external beam radiation therapy (EBRT) is a validated treatment option in the adjuvant setting for prostate cancer patients with aggressive pathological features following radical prostatectomy (RP) or as salvage modality in patients with biochemical recurrence after RP. Contemporary randomized phase III trials have provided evidence for using hypofractionation in the definitive treatment setting as an alternative to standard fractionated regimens. Biomathematical modeling for prostate cancer fractionated EBRT associated with widely available refined treatment delivery techniques such as volumetric modulated-arc therapy with image-guided RT may improve the therapeutic ratio...
November 14, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29174721/adjuvant-breast-radiotherapy-how-to-trade-off-cost-and-effectiveness
#12
Chris Monten, Yolande Lievens
INTRODUCTION: A series of health economic evaluations (HEE) has analysed the efficiency of new fractionation schedules and techniques for adjuvant breast radiotherapy. This overview assembles the available evidence and evaluates to what extent HEE-results can be compared. METHODS: Based on a systematic literature review of HEEs from 1/1/2000 to 30/10/2016, all cost comparison (CC) and cost-effectiveness analyses (CEA) comparing different adjuvant breast radiotherapy approaches were analysed...
November 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29173909/voxel-by-voxel-correlation-between-radiologically-radiation-induced-lung-injury-and-dose-after-image-guided-intensity-modulated-radiotherapy-for-lung-tumors
#13
Michele Avanzo, Sara Barbiero, Marco Trovo, Jean-Pierre Bissonnette, Rajesh Jena, Joseph Stancanello, Giovanni Pirrone, Fabio Matrone, Emilio Minatel, Cristina Cappelletto, Carlo Furlan, David A Jaffray, Giovanna Sartor
PURPOSE: To correlate radiation dose to the risk of severe radiologically-evident radiation-induced lung injury (RRLI) using voxel-by-voxel analysis of the follow-up computed tomography (CT) of patients treated for lung cancer with hypofractionated helical Tomotherapy. METHODS AND MATERIALS: The follow-up CT scans from 32 lung cancer patients treated with various regimens (5, 8, and 25 fractions) were registered to pre-treatment CT using deformable image registration (DIR)...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29165285/hypofractionated-nodal-radiation-therapy-for-breast-cancer-was-not-associated-with-increased-patient-reported-arm-or-brachial-plexopathy-symptoms
#14
MULTICENTER STUDY
Nelson Leong, Pauline T Truong, Keith Tankel, Winkle Kwan, Lorna Weir, Ivo A Olivotto
PURPOSE: To determine whether nodal radiation therapy (RT) for breast cancer using modest hypofractionation (HF) with 2.25 to 2.5 Gy per fraction (fx) was associated with increased patient-reported arm symptoms, compared with conventional fractionation (CF) ≤2 Gy/fx. METHODS AND MATERIALS: Two cancer registries were used to identify subjects who received computed tomography-planned nodal RT for pT1-3, pN0-2, M0 breast cancer, from 2007 to 2010 at 2 cancer institutions...
December 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29157747/multiplex-proximity-ligation-assay-to-identify-potential-prognostic-biomarkers-for-improved-survival-in-locally-advanced-pancreatic-cancer-patients-treated-with-stereotactic-body-radiation-therapy
#15
Avani D Rao, Yufei Liu, Rie von Eyben, Charles C Hsu, Chen Hu, Lauren M Rosati, Arti Parekh, Kendall Ng, Amy Hacker-Prietz, Lei Zheng, Timothy M Pawlik, Daniel A Laheru, Elizabeth M Jaffee, Matthew J Weiss, Dung T Le, Ralph H Hruban, Ana De Jesus-Acosta, Christopher L Wolfgang, Amol K Narang, Daniel T Chang, Albert C Koong, Joseph M Herman
PURPOSE: To explore seromarker levels for associations with outcomes in locally advanced pancreatic cancer (LAPC) patients who received chemotherapy and stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Serum from LAPC patients in 2 prospective trials of hypofractionated SBRT (5-6.6 Gy × 5) was collected before SBRT. Proximity ligation assay quantified the expression levels of 36 pancreatic cancer-specific candidate seromarkers: Axl, BMP2, CA 125, CA 19-9, CEA, CXCL-1/6/9/10, EGFR, Gas6, Her2, IGF-2, IGFBP-2/3/7, IL-6/6Ra/7/8/12, mesothelin, MMP-1/2/3/7, osteopontin, PDGFRa, PDK1, PF4, RegIV, SPARC, TGF-β, VEGF-A/D, and YKL40...
October 12, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29156657/moderate-hypofractionation-for-prostate-cancer
#16
EDITORIAL
Stefano Arcangeli, Giorgio Arcangeli
No abstract text is available yet for this article.
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29153463/late-normal-tissue-effects-in-the-arm-and-shoulder-following-lymphatic-radiotherapy-results-from-the-uk-start-standardisation-of-breast-radiotherapy-trials
#17
Joanne S Haviland, Mariella Mannino, Clare Griffin, Nuria Porta, Mark Sydenham, Judith M Bliss, John R Yarnold
BACKGROUND AND PURPOSE: Adjuvant lymphatic radiotherapy (LNRT) is recommended for selected axillary node positive women with early breast cancer. We investigated whether hypofractionated LNRT is safe combined with similarly-hypofractionated breast/chest wall radiotherapy (RT). MATERIAL AND METHODS: The Standardisation of Breast Radiotherapy (START) pilot, A and B trials randomised women with early breast cancer to schedules of 2.67-3.3 Gy versus 2.0 Gy fractions (control)...
November 15, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29152431/intensity-modulated-proton-therapy-with-advanced-planning-techniques-in-a-challenging-hepatocellular-carcinoma-patient
#18
Smith Apisarnthanarax, Jatinder Saini, Avril O'Ryan-Blair, Jackie Castro, Stephen R Bowen
The use of radiation therapy has been increasing over recent years for the treatment of hepatocellular carcinoma (HCC). Proton beam therapy (PBT) has emerged as a promising treatment option for HCC patients due to its dosimetric advantages of sparing more normal liver tissue from radiation at low to moderate doses compared to photon-based treatments while still delivering high doses of radiation to tumors. The PBT therapy may be particularly beneficial in high-risk HCC cirrhotic patients with large, bulky tumors and/or vascular invasion complicated by surrounding perfusion abnormalities...
September 10, 2017: Curēus
https://www.readbyqxmd.com/read/29137654/conventional-fractionation-should-not-be-the-standard-of-care-for-t2-glottic-cancer
#19
Lynne M Dixon, Catriona M Douglas, Shazril Imran Shaukat, Kate Garcez, Lip Wai Lee, Andrew J Sykes, David Thomson, Nicholas J Slevin
BACKGROUND: The aim of this study was to report outcomes and late toxicity following hypofractionated accelerated radiotherapy for T2 glottic cancers. We highlight the importance of hypofractionated treatments with shorter overall treatment times, in improving outcomes for T2 glottic cancers. We also compare the biologically effective dose of hypofractionated regimes, with conventional fractionation. METHODS: One hundred twelve patients with T2 glottic cancer were treated between January 1999 and December 2005...
November 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29132803/high-dose-irradiation-after-pleurectomy-decortication-or-biopsy-for-pleural-mesothelioma-treatment
#20
E Parisi, A Romeo, A Sarnelli, G Ghigi, S R Bellia, E Neri, S Micheletti, B Dipalma, D Arpa, G Furini, M A Burgio, G Genestreti, C Gurioli, S Sanna, P Bovolato, F Rea, G Storme, E Scarpi, C Arienti, A Tesei, R Polico
PURPOSE: The role played by radiation therapy after pleurectomy/decortication or surgical biopsy in malignant pleural mesothelioma is uncertain. We treated patients with accelerated hypofractionated radiotherapy using helical tomotherapy and intensity-modulated arc therapy in an attempt to keep lung toxicity to a minimum. The present study reports the feasibility and toxicity of this approach. MATERIAL AND METHODS: Between 2008 and 2012, 36 patients with malignant pleural mesothelioma underwent accelerated hypofractionated radiotherapy to the hemithorax after pleurectomy/decortication (19 patients) or biopsy (17 patients)...
November 10, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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