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Hypofractionation

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https://www.readbyqxmd.com/read/29032999/a-prospective-phase-i-comparison-of-toxicity-and-cosmesis-outcomes-of-single-fraction-iort-and-hypofractionated-radiotherapy-with-iort-boost-in-early-stage-breast-cancer
#1
Tanuja Bhandari, Wesley Babaran, Afshin Forouzannia, Venita Williams, Jay Harness, Michele Carpenter, Maher Gobran, Rajesh Khanijou, Brittany Wagman, Robert Ash, Lawrence D Wagman
PURPOSE: Radiation therapy is proven to reduce local recurrence in patients with early-stage breast cancer. To reduce toxicity, treatment time, and improve accuracy, intraoperative radiation therapy was used as definitive treatment or as a boost. The study's objective was to compare the short-term toxicity and cosmesis of single-fraction (SF) IORT and hypofractionated radiotherapy with IORT boost (HfB) given as definitive treatment. METHODS AND MATERIALS: Between March 2011 and December 2013, 57 patients aged 45-91 years and 24 patients aged 43-83 years (total n = 81) with Stage 0-II were treated with SF or HfB (Mobetron, IntraOp Medical, Sunnyvale, CA)...
October 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29021413/cyberknife-stereotactic-radiosurgery-and-hypofractionated-stereotactic-radiotherapy-as-first-line-treatments-for-imaging-diagnosed-intracranial-meningiomas
#2
Yoshihiko Manabe, Taro Murai, Hiroyuki Ogino, Takeshi Tamura, Michio Iwabuchi, Yoshimasa Mori, Hiromitsu Iwata, Hirochika Suzuki, Yuta Shibamoto
Definitive radiotherapy is an important alternative treatment for meningioma patients who are inoperable or refuse surgery. We evaluated the efficacy and toxicity of CyberKnife-based stereotactic radiosurgery (SRS) and hypofractionated stereotactic radiotherapy (hSRT) as first-line treatments for intracranial meningiomas that were diagnosed using magnetic resonance imaging (MRI) and/or computed tomography (CT). Between February 2005 and September 2015, 41 patients with intracranial meningiomas were treated with CyberKnife-based SRS or hSRT...
October 12, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28992239/investigation-of-the-efficacy-and-safety-of-cyberknife-hypofractionated-stereotactic-radiotherapy-for-brainstem-metastases-using-a-new-evaluation-criterion-symptomatic-control
#3
Masaki Nakamura, Hideki Nishimura, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Yasuo Ejima, Takeaki Ishihara, Ryo Nishikawa, Ryohei Sasaki
The treatment of brainstem metastases remains a challenge as the brainstem itself is considered a neurological organ at risk. We aimed to investigate the efficacy and safety of CyberKnife hypofractionated stereotactic radiotherapy (HFSRT) for brainstem metastases, and to examine the balance between efficacy and safety for the management of neurological symptoms. A total of 26 lesions [pons (n = 18), medulla (n = 4) and midbrain (n = 4)] in 20 patients treated with CyberKnife hypofractionated stereotactic radiotherapy were retrospectively analyzed...
August 10, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28983373/rectal-toxicity-after-extremely-hypofractionated-radiotherapy-using-a-non-isocentric-robotic-radiosurgery-system-for-early-stage-prostate-cancer
#4
Naoto Shikama, Yu Kumazaki, Kazunari Miyazawa, Keiji Nihei, Shinpei Hashimoto, Nobuhiro Tsukamoto
BACKGROUND: The aim of the study was to evaluate toxicity after extremely hypofractionated radiotherapy (EHF-RT) using a non-isocentric robotic radiosurgery system for early stage prostate cancer. METHODS: Eligibility criteria of this feasibility study were 50 - 84 years old, and low-risk to intermediate-risk disease. The prescribed dose to the iso-dose line of 95% of planning target volume was 35 Gy in five fractions over 2 weeks. The primary endpoint was the incidence of ≥ grade 2 acute toxicity which indicated symptoms requiring medications...
December 2016: World Journal of Oncology
https://www.readbyqxmd.com/read/28982908/long-term-tumor-control-and-late-toxicity-in-patients-with-prostate-cancer-receiving-hypofractionated-2-2-gy-soft-tissue-matched-image-guided-intensity-modulated-radiotherapy
#5
Daisuke Shimizu, Hideya Yamazaki, Takuya Nishimura, Norihiro Aibe, Haruumi Okabe
AIM: We report the long-term tumor control and toxicity outcomes of patients undergoing hypofractionated (2.2 Gy) image-guided intensity-modulated radiotherapy (IG-IMRT) using tomotherapy for clinically localized prostate cancer. PATIENTS AND METHODS: We examined the cases of 138 consecutive patients with stage T1-T3 prostate cancer that were treated with IG-IMRT from June 2007 to July 2009. The median follow-up time was 79 months (range=31-96 months). The planning target volume received a dose of 72...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982907/hypofractionated-postoperative-imrt-in-prostate-carcinoma-a-phase-i-ii-study
#6
Gabriella Macchia, Giambattista Siepe, Ilaria Capocaccia, Nam P Nguyen, Riccardo Schiavina, Silvia Cammelli, Sara Guerri, Alessandra Arcelli, Milly Buwenge, Maria Ntreta, Savino Cilla, Vincenzo Valentini, Francesco Deodato, Alessio G Morganti
AIM: To report the outcome of hypofractionated radiotherapy after radical prostatectomy (RP) for prostate cancer (PCa) using simultaneous integrated boost-intensity modulated radiation therapy (SIB-IMRT). PATIENTS AND METHODS: A total of 124 patients with PCa at high risk of relapse after RP or diagnosis of biochemical relapse were included. Patients received 62.5 Gy to the prostate bed and 45 Gy to pelvic nodes in 25 fractions. Androgen-suppressive therapy was prescribed based on National Comprehensive Cancer Network risk categories...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982291/intranasal-melanoma-treated-with-radiation-therapy-in-three-dogs
#7
Owen Davies, Sarah Spencer, Slavomira Necova, Emma Holmes, Angela Taylor, Laura Blackwood, Ana Lara-Garcia
Three dogs were investigated for chronic unilateral nasal discharge. In all cases CT imaging showed an intranasal mass causing turbinate lysis and no evidence of metastasis. Cytology in cases 1 (a 14-year-old neutered male crossbreed dog) and 2 (a five-year-old neutered male German Shepherd dog) demonstrated a pleomorphic cell population with variable intracellular pigment suspicious of melanocytic neoplasia. Histopathology with immunohistochemistry (Melan-A and vimentin, plus PNL-2 in one case) confirmed the diagnosis of melanoma in all dogs...
October 6, 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28980442/automated-prediction-of-dosimetric-eligibility-for-hypofractionated-prostate-radiotherapy
#8
Anthony Lausch, Michael Lamey, Grace G Zeng
Clinical implementation of hypofractionated prostate radiotherapy (PROFIT trial, NCT003046759) represents an opportunity to significantly reduce the burden of treatment on the patient and clinic. However, efficacy was only demonstrated among the patient demographic who could meet the trial dose constraints and so it is necessary to emulate this triage step in clinical practice. The purpose of this study was to build a convenient tool to address the challenge of determining patient eligibility for hypofractionated treatment within the clinic...
October 4, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28978064/are-three-weeks-hypofractionated-radiation-therapy-hfrt-comparable-to-six-weeks-for-newly-diagnosed-glioblastoma-patients-results-of-a-phase-ii-study
#9
Pierina Navarria, Federico Pessina, Stefano Tomatis, Riccardo Soffietti, Marco Grimaldi, Egesta Lopci, Arturo Chiti, Antonella Leonetti, Alessandra Casarotti, Marco Rossi, Luca Cozzi, Anna Maria Ascolese, Matteo Simonelli, Simona Marcheselli, Armando Santoro, Elena Clerici, Lorenzo Bello, Marta Scorsetti
BACKGROUND: The current standard of care for newly diagnosed glioblastoma (GBM) is surgical resection, followed by radiation therapy (RT) with concurrent and adjuvant temozolomide chemotherapy (TMZ-CHT). The patients outcome is still poor. In this study we evaluated hypofractionated radiation therapy (HFRT), instead of standard fractionated radiation therapy, with concomitant and adjuvant TMZ chemotherapy, in terms of safety and effectiveness. METHODS: Patients with newly diagnosed GBM, Karnofsky performance scale (KPS) ≥70, and tumor up to 10 cm underwent maximal feasible surgical resection were treated...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974415/hypofractionated-stereotactic-radiation-therapy-to-the-resection-bed-for-intracranial-metastases
#10
Audrey Keller, Mélanie Doré, Hélène Cebula, François Thillays, François Proust, Ioana Darié, Stéphane-André Martin, Gregory Delpon, François Lefebvre, Georges Noël, Delphine Antoni
PURPOSE: To retrospectively report the outcomes of a large multicenter cohort of patients treated with surgery and hypofractionated stereotactic radiation therapy (HFSRT) to the resection cavities of brain metastases (BMs). METHODS AND MATERIALS: Between March 2008 and February 2015, 181 patients with no prior whole-brain radiation therapy (WBRT) were treated by HFSRT to the surgical bed of BM at the dose of 33 Gy (3 × 11 Gy). The primary endpoint was local control...
August 19, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28973074/consolidative-radiotherapy-for-limited-metastatic-non-small-cell-lung-cancer-a-phase-2-randomized-clinical-trial
#11
Puneeth Iyengar, Zabi Wardak, David E Gerber, Vasu Tumati, Chul Ahn, Randall S Hughes, Jonathan E Dowell, Naga Cheedella, Lucien Nedzi, Kenneth D Westover, Suprabha Pulipparacharuvil, Hak Choy, Robert D Timmerman
Importance: Patterns-of-failure studies suggest that in metastatic non-small-cell lung cancer (NSCLC) sites of gross disease at presentation are the first to progress when treated with chemotherapy. This knowledge has led to increased adoption of local ablative radiation therapy in patients with stage IV NSCLC, though prospective randomized evidence is limited. Objective: To determine if intervening with noninvasive stereotactic ablative radiotherapy (SAbR) prior to maintenance chemotherapy in patients with non-progressive limited metastatic NSCLC after induction therapy led to significant improvements in progression-free survival (PFS)...
September 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28964586/hospital-quality-factors-influencing-the-mobility-of-patients-for-radical-prostate-cancer-radiation-therapy-a-national-population-based-study
#12
Ajay Aggarwal, Daniel Lewis, Arunan Sujenthiran, Susan C Charman, Richard Sullivan, Heather Payne, Malcolm Mason, Jan van der Meulen
PURPOSE: To investigate whether patients requiring radiation treatment are prepared to travel to alternative more distant centers in response to hospital choice policies, and the factors that influence this mobility. METHODS AND MATERIALS: We present the results of a national cohort study using administrative hospital data for all 44,363 men who were diagnosed with prostate cancer and underwent radical radiation therapy in the English National Health Service between 2010 and 2014...
August 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28959169/high-dose-hypofractionated-proton-beam-therapy-is-a-safe-and-feasible-treatment-for-central-lung-cancer
#13
Takashi Ono, Tomonori Yabuuchi, Tatsuya Nakamura, Kanako Kimura, Yusuke Azami, Katsumi Hirose, Motohisa Suzuki, Hitoshi Wada, Yasuhiro Kikuchi, Kenji Nemoto
BACKGROUND: There have been few reports about high total dose hypofractionated proton beam therapy for central lung cancer. The aim of this study was to examine retrospectively the safety and efficacy of high total dose hypofractionated proton beam therapy for central lung cancer. PATIENTS AND METHODS: Patients treated by proton beam therapy for central lung cancer located less than 2 cm from the trachea, mainstem bronchus, or lobe bronchus were included in this study...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28958838/trastuzumab-and-hypofractionated-whole-breast-radiotherapy-a-victorious-combination
#14
Maria Carmen De Santis, Francesca Bonfantini, Francesca Di Salvo, Alba Fiorentino, Valentina Maria Riboldi, Serena Di Cosimo, Giulia Valeria Bianchi, Massimiliano Gennaro, Vito Cosentino, Milena Sant, Emanuele Pignoli, Riccardo Valdagni, Laura Lozza
INTRODUCTION: The purpose of this study was to examine the impact of trastuzumab on acute skin and cardiac toxicity in patients with breast cancer treated with chemotherapy with or without trastuzumab and adjuvant whole breast hypofractionated radiotherapy (hypo-RT). MATERIALS AND METHODS: The study was conducted on 727 patients treated from April 2009 to October 2016. Patients received 42.4 Gy in 16 daily fractions (2.65 Gy per fraction). A boost was only administered in cases with grade (G) 3 primary tumor and close or positive margins...
August 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28951010/spatiotemporal-fractionation-schemes-for-liver-stereotactic-body-radiotherapy
#15
Jan Unkelbach, Dávid Papp, Melissa R Gaddy, Nicolaus Andratschke, Theodore Hong, Matthias Guckenberger
BACKGROUND AND PURPOSE: Dose prescription in stereotactic body radiotherapy (SBRT) for liver tumors is often limited by the mean liver dose. We explore the concept of spatiotemporal fractionation as an approach to facilitate further dose escalation in liver SBRT. MATERIALS AND METHODS: Spatiotemporal fractionation schemes aim at partial hypofractionation in the tumor along with near-uniform fractionation in normal tissues. This is achieved by delivering distinct dose distributions in different fractions, which are designed such that each fraction delivers a high single fraction dose to complementary parts of the tumor while creating a similar dose bath in the surrounding noninvolved liver...
September 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28948117/management-of-nasal-septum-chondrosarcoma-occurring-in-elderly-a-case-report
#16
Liliana Belgioia, Elena M Vaccara, Almalina Bacigalupo, Renzo Corvò
Chondrosarcomas (CS) are tumors affecting mainly pelvis, long bones and ribs in middle aged people; involvement of head and neck is rare and nasal septum location is exceptional. We report the follow-up of an 85-year-old patient suffering from head and neck CS. Magnetic resonance imaging (MRI) showed a mass originating from nasal septum. The patient underwent to debulking surgery and adjuvant hypofractionated radiotherapy with excellent tolerability and no evidence of recurrence after 16 months. Hypofractionated radiotherapy delivered with advanced technique (helical tomotherapy) allowed to deliver high doses radiation in elderly patients with limited toxicity...
July 20, 2017: Curēus
https://www.readbyqxmd.com/read/28943074/local-protocol-variations-for-image-guided-radiation-therapy-in-the-multicenter-dutch-hypofractionation-hypro-trial-impact-of-rectal-balloon-and-mri-delineation-on-anorectal-dose-and-gastrointestinal-toxicity-levels
#17
R C Wortel, W D Heemsbergen, R J Smeenk, M G Witte, A D Krol, F J Pos, L Incrocci
PURPOSE: The phase 3 HYpofractionated irradiation for PROstate cancer (HYPRO) trial randomized patients with intermediate- to high-risk localized prostate cancer to conventionally fractionated (78 Gy in 39 fractions) or hypofractionated (64.6 Gy in 19 fractions) radiation therapy. Differences in techniques and treatment protocols were present between participating centers. This study aimed to compare dose parameters and patient-reported gastrointestinal symptoms between these centers...
August 3, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28939224/phase-1-2-dose-escalation-study-of-the-use-of-intensity-modulated-radiation-therapy-to-treat-the-prostate-and-pelvic-nodes-in-patients-with-prostate-cancer
#18
Miguel Reis Ferreira, Atia Khan, Karen Thomas, Lesley Truelove, Helen McNair, Annie Gao, Chris C Parker, Robert Huddart, Margaret Bidmead, Ros Eeles, Vincent Khoo, Nicholas J van As, Vibeke N Hansen, David P Dearnaley
PURPOSE: To investigate the feasibility of dose escalation and hypofractionation of pelvic lymph node intensity modulated radiation therapy (PLN-IMRT) in prostate cancer (PCa). METHODS AND MATERIALS: In a phase 1/2 study, patients with advanced localized PCa were sequentially treated with 70 to 74 Gy to the prostate and dose-escalating PLN-IMRT at doses of 50 Gy (cohort 1), 55 Gy (cohort 2), and 60 Gy (cohort 3) in 35 to 37 fractions. Two hypofractionated cohorts received 60 Gy to the prostate and 47 Gy to PLN in 20 fractions over 4 weeks (cohort 4) and 5 weeks (cohort 5)...
August 2, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28939179/heart-dose-associated-with-overall-survival-in-locally-advanced-nsclc-patients-treated-with-hypofractionated-chemoradiotherapy
#19
Barbara Stam, Erik van der Bijl, Judi van Diessen, Maddalena M G Rossi, Angela Tijhuis, José S A Belderbos, Eugène Damen, Jan-Jakob Sonke
Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V2Gy:HR=1.007%(-1) (95% CI:1.002-1.013; p=0.006), age:HR=1.026year(-1) (1.011-1.042; p=0.001) and GTV volume:HR=1.001cc(-1) (1.000-1.002; p=0.006) with overall survival.
September 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28939097/effect-of-endoscopic-bronchial-ultrasound-on-outcomes-for-stage-i-non-small-cell-lung-cancer-patients-receiving-hypofractionated-radiotherapy
#20
Adil S Akthar, Matthew Koshy, Mark K Ferguson, Septimiu Murgu, D Kyle Hogarth, Daniel W Golden, Philip P Connell, Erik M Davies, Eric Kowalski, Renuka Malik
BACKGROUND: In this study we sought to determine if staging endoscopic bronchial ultrasound (EBUS) improves outcomes in stage I non-small-cell lung cancer (NSCLC) patients who received hypofractionated radiation therapy (HFRT). PATIENTS AND METHODS: Patients with stage I NSCLC treated with HFRT from 2008 to 2015 were retrospectively identified from 3 affiliated institutions. All patients underwent positron emission tomography/computed tomography staging and a subset of patients received pretreatment EBUS...
August 31, 2017: Clinical Lung Cancer
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