keyword
https://read.qxmd.com/read/38546109/steven-jonhson-syndrome-in-a-patient-with-dengue-infection-in-peru-a-case-report
#1
JOURNAL ARTICLE
Winny D Aparcana-Choque, Yadira M Pisconti-Palacios, Ivan Cordova-Tello, Jhon Ausejo-Galarza, Walter Gomez-Gonzales, Andrei Kochubei-Hurtado, Kovy Arteaga-Livias
Stevens-Johnson syndrome is an infrequent condition affecting the skin and mucous membranes, it involves cutaneous detachment with high mortality without adequate treatment. We present the case of a 40-year-old male with a history of epilepsy treated with valproic acid and lamotrigine, previously diagnosed with dengue. Evaluation showed erythematous blisters on skin and mucosa with bleeding and desquamation, covering 10% of the body surface. The patient progressed favorably with the medical care received. Stevens-Johnson syndrome should be studied in association with arboviral diseases...
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38545494/severe-cutaneous-adverse-reactions-in-a-tertiary-care-center-in-jamaica
#2
JOURNAL ARTICLE
Alicia J S McNish, Jonathan D Ho, Althea D C East-Innis
BACKGROUND: Severe cutaneous adverse reactions (SCARs) are associated with morbidity and mortality. OBJECTIVE: The aim was to determine the different types of SCARs, their morphology, common offending drugs, interventions, and outcomes. METHODS: A retrospective cohort study was conducted of all patients admitted to the dermatology service at the University Hospital of the West Indies with Stevens-Johnson syndrome (SJS), SJS/toxic epidermal necrolysis overlap (TEN), TEN, drug reaction with eosinophilia and systemic symptoms and acute generalized exanthematous pustulosis between January 1, 2012 to June 1, 2022...
June 2024: JAAD international
https://read.qxmd.com/read/38537425/real-world-safety-of-levetiracetam-mining-and-analysis-of-its-adverse-drug-reactions-based-on-faers-database
#3
JOURNAL ARTICLE
Zhimin He, Cuimin Liu, Lin Lin, Guowen Feng, Gang Wu
INTRODUCTION: Levetiracetam is a relatively new and widely utilized anti-seizure medication; however, limited information is available regarding its adverse effects. This study aims to thoroughly investigate, evaluate, and present evidence on the safety profile of Levetiracetam, relying on data from the FDA Adverse Event Reporting System (FAERS) database to facilitate informed clinical decision-making. METHODS: We employed various statistical measures, including Reporting Odds Ratio (ROR), Proportionate Reporting Ratio (PRR), and analysis by the Medicines and Healthcare Products Regulatory Agency (MHRA), to identify signals of adverse reactions associated with Levetiracetam...
March 21, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38531617/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-hong-kong
#4
JOURNAL ARTICLE
C M T Cheung, M M Chang, J J X Li, A W S Chan
INTRODUCTION: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) [hereafter, SJS/TEN] are uncommon but severe mucocutaneous reactions. Although they have been described in many populations worldwide, data from Hong Kong are limited. Here, we explored the epidemiology, disease characteristics, aetiology, morbidity, and mortality of SJS/TEN in Hong Kong. METHODS: This retrospective cohort study included all hospitalised patients who had been diagnosed with SJS/TEN in Prince of Wales Hospital from 1 January 2004 to 31 December 2020...
March 26, 2024: Hong Kong Medical Journal
https://read.qxmd.com/read/38528364/association-between-articular-eminence-structure-and-joint-spaces-in-temporomandibular-joints-with-anterior-disc-displacement
#5
JOURNAL ARTICLE
M Etöz, D Soydan Çabuk, N Kütük, I Ercan
BACKGROUND AND AIMS: The association among the joint spaces, articular eminence morphology, and disc displacement is not well documented in the literature. This study aims to evaluate and compare the joint spaces and the articular eminence structure (eminence height [Eh] and inclination [Ei]) using cone-beam computed tomography (CBCT) of temporomandibular joints (TMJs) with anterior disc displacements and joints with normal disc position. METHODS: The study groups consisted of 75 TMJs of 39 patients...
March 1, 2024: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38527607/cefazolin-as-the-mainstay-for-antibiotic-prophylaxis-in-penicillin-allergic-patients-in-obstetrics-and-gynecology
#6
JOURNAL ARTICLE
Karley J Dutra, Gweneth B Lazenby, Oluwatosin Goje, David E Soper
Cefazolin is the most common antibiotic used for prophylaxis in obstetrics and gynecology. Among those with a penicillin allergy, alternative antibiotics are often chosen for prophylaxis given fears of cross-reactivity between penicillin and cefazolin. Alternative antibiotics in this setting are associated with adverse sequalae including surgical site infection, induction of bacterial resistance, higher costs to the healthcare system, and possible Clostridium difficile infection. Given the difference in R1 side chains between the penicillin and cefazolin, cefazolin use is safe and should be recommended for penicillin allergic patients including those who experience IgE-mediated reactions such as anaphylaxis...
March 23, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38527170/unraveling-the-genetic-link-an-umbrella-review-on-hla-b-15-02-and-antiepileptic-drug-induced-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#7
JOURNAL ARTICLE
Kar Mun Tham, Jacklyn Jia Lin Yek, Christopher Wei Yang Liu
PURPOSE: This umbrella review was conducted to summarize the association between HLA*1502 allele with antiepileptic induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). METHODS: Pubmed, Scopus and EMBASE were searched for eligible reviews in May 2023. Two authors independently screened titles and abstracts and assessed full-text reviews for eligibility. The quality of meta-analyses and case-control studies was appraised with Assessing the Methodological Quality of Systematic Reviews 2 and Newcastle-Ottawa Scale, respectively...
March 22, 2024: Pharmacogenetics and Genomics
https://read.qxmd.com/read/38526521/not-all-mucosal-rashes-after-lamotrigine-are-stevens-johnson-syndrome-case-of-mycoplasma-pneumoniae-induced-rash-and-mucositis-and-review-of-differential-diagnosis
#8
JOURNAL ARTICLE
Connor Dean, Samantha Ongchuan, Sahil Munjal
No abstract text is available yet for this article.
March 26, 2024: Journal of Clinical Psychopharmacology
https://read.qxmd.com/read/38524655/capecitabine-and-oxaliplatin-induced-steven-johnson-syndrome-following-nivolumab-in-a-patient-of-metastatic-esophageal-carcinoma
#9
JOURNAL ARTICLE
Sumit Kumar, Anthialisha Nongkynrih, Biswajit Dey, Vikas Jagtap, Reena Lamba, Deiwakor Chyrmang
Stevens-Johnson syndrome presents as mucocutaneous blistering and sloughing, which may follow a devastating clinical course. Although Stevens-Johnson syndrome has been reported following the administration of anticancer drugs, only a few cases induced by cytotoxic anticancer drugs, administered after immune checkpoint inhibitors, have been reported. The present report describes a case of Stevens-Johnson syndrome caused by capecitabine and oxaliplatin (CAPEOX) combination chemotherapy, in a patient with esophageal squamous cell carcinoma, who had been previously treated with nivolumab...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524512/double-plasma-molecular-adsorption-system-for-stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-case-report
#10
You-Wen Tan, Li-Ping Liu, Kai Zhang
BACKGROUND: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are very serious skin allergies, with an etiology related to infections and medication. Since the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus-2 has also been considered to cause SJS/TEN. CASE SUMMARY: We report the case of a woman in her thirties who took acetaminophen after contracting COVID-19. After 3 d of fever relief, she experienced high fever and presented with SJS/TEN symptoms, accompanied by intrahepatic cholestasis...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38524158/restless-legs-syndrome-periodic-limb-movements-of-sleep-and-subclinical-cardiovascular-disease
#11
JOURNAL ARTICLE
Kevin J Hochstrasser, Steven C Rogers, Arshed Quyyumi, Dayna Johnson, Victoria Pak, Amit J Shah, David B Rye, Lynn Marie Trotti
UNLABELLED: Restless legs syndrome (RLS) and periodic limb movements of sleep (PLMS) have been variably implicated in risk for cardiovascular disease (CVD), but there is lack of consensus on these relationships. We sought to assess subclinical CVD measures and RLS/PLMS in a large cohort to further evaluate these associations. The Emory Center for Health Discovery and Well Being cohort is composed of employed adults, with subclinical CVD measures including endothelial function (flow-mediated vasodilation), microvascular function (reactive hyperemia index, RHI), arterial stiffness (pulse wave velocity and augmentation index), and carotid intima-media thickness (cIMT)...
April 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38518064/lessons-learned-from-ocular-graft-versus-host-disease-an-ocular-surface-inflammatory-disease-of-known-time-of-onset
#12
JOURNAL ARTICLE
Manuel E Quiroga-Garza, Raul E Ruiz-Lozano, Luis A Rodriguez-Gutierrez, Ali Khodor, Symon Ma, Seitaro Komai, Karim Mohamed-Noriega, Victor L Perez
The ocular surface inflammatory disorders (OSIDs) comprise a group of conditions characterized by persistent inflammation of the ocular surface and adnexal tissues. Systemic autoimmune diseases and hypersensitivity reactions cause them, and, if left untreated, can result in severe inflammatory dry eye, corneal damage, and vision loss. Ocular graft-versus-host disease (oGVHD) forms part of the ocular surface inflammatory disease umbrella. It is a condition occurring after allogeneic hematopoietic stem cell or bone marrow transplantation, usually in chronic graft-versus-host disease...
March 22, 2024: Eye & Contact Lens
https://read.qxmd.com/read/38515984/editorial-stevens-johnson-syndrome-past-present-and-future-directions
#13
EDITORIAL
Hajirah N Saeed, Robert Micheletti, Elizabeth J Phillips
No abstract text is available yet for this article.
2024: Frontiers in Medicine
https://read.qxmd.com/read/38515064/quantitative-and-qualitative-condylar-changes-following-stabilization-splint-therapy-in-patients-with-temporomandibular-joint-disorders-with-and-without-skeletal-lateral-mandibular-asymmetry-a-cone-beam-computed-tomographic-study
#14
JOURNAL ARTICLE
Mazen Musa, Riham Awad, Salma Izeldin, Yunshan Zhao, Hao Wu, Lu Wang, Saba Ahmed Al-Hadad, Bdr Sultan Saif, Madiha Mohammed Saleh Ahmed, Xi Chen
BACKGROUND: Temporomandibular disorders (TMDs) encompass pain and dysfunction in the jaw, muscles, and adjacent structures. This study aimed to explore the quantitative (condylar position, morphology) and qualitative (bone mineral density (BMD)) therapeutic outcomes following a stabilization splint (S.S.) therapy in adult patients diagnosed with TMD (Arthralgia) with/without lateral mandibular asymmetry (MA) using cone beam computed tomography (CBCT). METHODS: In this retrospective clinical study, 60 adult TMD patients who received S...
March 21, 2024: BMC Oral Health
https://read.qxmd.com/read/38510251/functional-significance-of-dna-methylation-epigenetic-insights-into-sj%C3%A3-gren-s-syndrome
#15
REVIEW
Yanqing Wang, Farooq Riaz, Wei Wang, Jincheng Pu, Yuanyuan Liang, Zhenzhen Wu, Shengnan Pan, Jiamin Song, Lufei Yang, Youwei Zhang, Huihong Wu, Fang Han, Jianping Tang, Xuan Wang
Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenetic mechanisms contribute to the pathophysiology of SjS by modulating gene expression and genome stability. DNA methylation, a form of epigenetic modification, is the fundamental mechanism that modifies the expression of various genes by modifying the transcriptional availability of regulatory regions within the genome...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38507192/clinical-characteristics-and-treatment-of-ophthalmic-sequelae-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-at-a-tertiary-eyecare-centre-in-hungary
#16
JOURNAL ARTICLE
Gábor Tóth, Andrea Lukács, Tanja Stachon, Frank Schirra, Gábor László Sándor, Zoltán Zsolt Nagy, Nóra Szentmáry
INTRODUCTION: This study analysed the causative factors and clinical characteristics of acute and chronic ocular sequelae of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) treated at a large third-referral centre in a developed country (Hungary) over a 15-year period. METHODS: This was a retrospective review of patients with acute and/or chronic SJS/TEN who were managed between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University in Budapest, Hungary...
March 20, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38498147/-update-on-sj%C3%A3-gren-s-syndrome-diagnostics-treatment-and-challenges
#17
JOURNAL ARTICLE
Nadine Zehrfeld, Torsten Witte, Diana Ernst
Sjögren's syndrome (SjS) is the most common connective tissue disease with a prevalence of 1:200. Predominantly affecting women, SjS is associated with destruction of the exocrine glands, leading to xerophthalmia and xerostomia. In over 50% of patients, there are also extraglandular manifestations, leading to multiple organ manifestations including polyneuropathies and interstitial lung disease as well as symptoms such as fatigue and arthralgia. Diagnostic procedures include biomarkers, in particular anti-SS-A/Ro antibodies, histology of salivary glands, and salivary gland sonography...
March 18, 2024: Zeitschrift Für Rheumatologie
https://read.qxmd.com/read/38497506/the-current-application-and-evidence-for-robotic-approach-in-abdominal-surgery-a-narrative-literature-review
#18
REVIEW
Niclas Dohrn, Stefan Kobbelgaard Burgdorf, Pieter de Heer, Mads Falk Klein, Kristian Kiim Jensen
The current application of robotic surgery is evolving at a high pace in the current years. The technical advantages enable several abdominal surgical procedures to be performed minimally invasive instead of open surgery. Furthermore, procedures previously performed successfully using standard laparoscopy are now performed with a robotic approach, with conflicting results. The present narrative review reports the current literature on the robotic surgical procedures typically performed in a typical Scandinavian surgical department: colorectal, hernia, hepato-biliary, and esophagogastric surgery...
March 18, 2024: Scandinavian Journal of Surgery: SJS
https://read.qxmd.com/read/38490716/long-term-outcomes-of-glued-sutureless-amniotic-membrane-transplantation-in-acute-stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-comparative-study
#19
JOURNAL ARTICLE
Ramy Rashad, James T Kwan, Swapna S Shanbhag, Panotsom Ngowyutagon, Musa Saeed, Mohammad A Tahboub, Abid Haseeb, James Chodosh, Hajirah N Saeed
PURPOSE: To compare the effectiveness and efficiency of a glued (sutureless) technique for amniotic membrane transplantation (AMT) with a traditional sutured one in the setting of acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). METHODS: This retrospective cohort study evaluated all patients diagnosed with SJS/TEN between 2008 and 2020 within our hospital network who received AMT in the acute phase according to our protocol and had at least one ophthalmic follow-up in the chronic phase...
March 15, 2024: British Journal of Ophthalmology
https://read.qxmd.com/read/38490474/unique-cytokine-signature-in-ocular-stevens-johnson-syndrome-non-responders
#20
JOURNAL ARTICLE
Srividya Gurumurthy, Bhaskar Srinivasan, Shweta Agarwal, Hiren Matai, Narayanasamy Angayarkanni, Geetha Iyer
PURPOSE: To clinically define a subset of patients with chronic ocular Stevens-Johnson syndrome non-responders (SJS-NR) and analyze their cytokine profile compared to clinical responders (SJS-CR). METHODS: A total of 32 SJS cases (n = 32, 64 eyes) managed over a period of three years were segregated into clinical responders (n = 24, 48 eyes) and non-responders (n = 8, 16 eyes). Cases were determined as non-responders based on persistent, refractory, and non-mechanical inflammation of the conjunctiva...
March 13, 2024: Ocular Surface
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