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https://www.readbyqxmd.com/read/29105735/research-directions-in-genetic-predispositions-to-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#1
Teri A Manolio, Carolyn M Hutter, Mark Avigan, Ricardo Cibotti, Robert L Davis, Joshua C Denny, Lois La Grenade, Lisa M Wheatley, Mary N Carrington, Wasun Chantratita, Wen-Hung Chung, Andrea D Dalton, Shuen-Iu Hung, Ming Ta Michael Lee, J Steven Leeder, Juan J L Lertora, Surakameth Mahasirimongkol, Howard L McLeod, Maja Mockenhaupt, Michael Pacanowski, Elizabeth J Phillips, Simone Pinheiro, Munir Pirmohamed, Cynthia Sung, Wimon Suwankesawong, Lauren Trepanier, Santa J Tumminia, David Veenstra, Rika Yuliwulandari, Neil H Shear
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.
November 6, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29092775/cytokines-as-therapeutic-targets-in-primary-sj%C3%A3-gren-syndrome
#2
REVIEW
Soledad Retamozo, Alejandra Flores-Chavez, Marta Consuegra-Fernández, Francisco Lozano, Manuel Ramos-Casals, Pilar Brito-Zerón
Primary Sjögren syndrome (SjS) is a systemic autoimmune disease that may affect 1 in 1000 people (overwhelmingly women) and that can be a serious disease with excess mortality due to severe organ-specific involvements and the development of B cell lymphoma; systemic involvement clearly marks the disease prognosis, and strongly suggests the need for closer follow-up and more robust therapeutic management. Therapy is established according to the organ involved and severity. As a rule, the management of systemic SjS should be organ-specific, with glucocorticoids and immunosuppressive agents limited to potentially-severe involvements; unfortunately, the limited evidence available for these drugs, together with the potential development of serious adverse events, makes solid therapeutic recommendations difficult...
October 29, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29078844/risk-of-ischemic-heart-disease-in-patients-with-sj%C3%A3-gren-s-syndrome
#3
Faraz Khan Luni, Sonia Ali Malik, Abdur Rahman Khan, Haris Riaz, Hemindermeet Singh, Douglas Federman, Yusuf Kanjwal, Osama Dasa, Sadik Khuder, Ameer Kabour
BACKGROUND: Ischemic heart disease (IHD) has emerged as a major cause of morbidity and mortality in patients with autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis, but the risk of IHD in Sjögren's syndrome (SjS) is unknown. To fill this knowledge gap, we estimated the prevalence and risk of IHD with SjS compared to controls from the general population using the Healthcare Cost and Utilization Project National Inpatient Sample 2011 database. MATERIALS AND METHODS: The Healthcare Cost and Utilization Project administrative longitudinal database contains encounter-level information on inpatient stays, emergency department visits and ambulatory surgery in all U...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29076438/stevens-johnson-syndrome-versus-jarisch-herxheimer-reaction-in-an-hiv-positive-patient-with-secondary-syphilis
#4
Sarah Micozzi, Patricia Rojas Perez-Ezquerra, Cristina Morales-Cabeza, Cristina Diez, Manuel De Barrio
BACKGROUND: HIV positive patients can suffer many complications due to infectious diseases. A severe reaction to some of the drugs involved in the treatment can overlap with the symptoms of infections, making diagnosis very difficult. We present the case of an HIV positive 28-year-old-man, , with secondary syphilis, who developed a Stevens Johnson Syndrome (SJS) caused by one of the many drugs he was receiving. The SJS overlapped with a possible Jarisch Herxheimer Reaction, which complicated diagnosis of the skin reaction...
October 26, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29076187/the-association-of-hla-b-15-02-allele-and-stevens-johnson-syndrome-toxic-epidermal-necrolysis-induced-by-aromatic-anticonvulsant-drugs-in-a-south-indian-population
#5
Keerankulangara Devi
BACKGROUND: The presence of HLA-B*15:02 allele is considered a risk factor for development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in patients taking aromatic anticonvulsant drugs like carbamazepine and phenytoin. The genetic association is ethnicity specific. Testing for HLA-B*15:02 allele is suggested as a prerequisite before starting carbamazepine in certain ethnic groups. There are only a few/no studies from south India on HLA association of SJS/TEN. AIMS: To identify any association between HLA-B*15:02 allele and SJS/TEN induced by carbamazepine/phenytoin among native population...
October 26, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29065621/comparison-of-morphologic-parameters-of-temporomandibular-joint-for-asymptomatic-subjects-using-the-two-dimensional-and-three-dimensional-measuring-methods
#6
Yuanli Zhang, Xianchao Xu, Zhan Liu
The differences of temporomandibular joint (TMJ) morphologic parameters by using two-dimensional (2D) and three-dimensional (3D) measuring methods were compared. Ten asymptomatic subjects (26.75 ± 4.89 years) were randomly recruited. The 3D models of the maxilla, mandible, and teeth were reconstructed according to cone-beam computed tomography (CBCT) image data. The morphologic parameters of TMJs were measured by the 2D CBCT measuring method (group A) and the 3D reconstruction model measuring method (group B), respectively...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29058836/-the-major-scar-syndromes
#7
G E Piérard, M Lesuisse, C Piérard-Franchimont
Some drug eruptions are frequent and follow an indolent course, while others prove to be life-threatening. By contrast, SCAR syndromes are serious skin drug reactions that are rare but their vital prognosis is affected. The three distinct entities of importance are the former Lyell's syndrome, now identified as SJS-TEN syndrome (Stevens-Johnson syndrome/toxic epidermal necrolysis), the DRESS syndrome (drug reaction with eosinophilia and systemic symptoms), and the AGEP syndrome (acute generalized exanthematous pustulosis)...
October 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29053440/association-of-the-hla-b-alleles-with-carbamazepine-induced-stevens-johnson-syndrome-toxic-epidermal-necrolysis-in-the-javanese-and-sundanese-population-of-indonesia-the-important-role-of-the-hla-b75-serotype
#8
Rika Yuliwulandari, Erna Kristin, Kinasih Prayuni, Qomariyah Sachrowardi, Franciscus D Suyatna, Sri Linuwih Menaldi, Nuanjun Wichukchinda, Surakameth Mahasirimongkol, Larisa H Cavallari
Carbamazepine (CBZ) is a common cause of life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Previous studies have reported a strong association between the HLA genotype and CBZ-induced SJS/TEN. We investigated the association between the HLA genotype and CBZ-induced SJS/TEN in Javanese and Sundanese patients in Indonesia. Nine unrelated patients with CBZ-induced SJS/TEN and 236 healthy Javanese and Sundanese controls were genotyped for HLA-B and their allele frequencies were compared...
October 20, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/29052094/severe-physical-complications-among-survivors-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#9
Cristina Olteanu, Neil H Shear, Hall F Chew, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Michael Ziv, Shachar Sade, Marc G Jeschke, Roni P Dodiuk-Gad
INTRODUCTION: Few studies have reported the physical complications among Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors. OBJECTIVE: The aim of this study was to comprehensively characterize the physical complications among SJS/TEN survivors and to learn about patients' perspectives of surviving SJS/TEN. METHODS: SJS/TEN survivors older than 18 years of age were assessed by different methods: a medical interview; a questionnaire assessing patients' perspectives; thorough skin, oral mucous membrane, and ophthalmic examinations; and a retrospective assessment of medical records...
October 19, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29029855/improving-mortality-outcomes-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-regional-burns-centre-experience
#10
M Nizamoglu, J A Ward, Q Frew, H Gerrish, N Martin, A Shaw, D Barnes, O Shelly, B Philp, N El-Muttardi, P Dziewulski
INTRODUCTION: Stevens Johnson Syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, potentially fatal desquamative disorders characterised by large areas of partial thickness skin and mucosal loss. The degree of epidermal detachment that occurs has led to SJS/TEN being described as a burn-like condition. These patients benefit from judicious critical care, early debridement and meticulous wound care. This is best undertaken within a multidisciplinary setting led by clinicians experienced in the management of massive skin loss and its sequelae...
October 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29027197/the-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-new-users-of-antiepileptic-drugs
#11
Noel Frey, Michael Bodmer, Andreas Bircher, Stephan Rüegg, Susan S Jick, Christoph R Meier, Julia Spoendlin
OBJECTIVE: Older antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). However, evidence for newer AED is sparse. We quantified risks of SJS/TEN in association with use of all AEDs in the United Kingdom. METHODS: In a matched case-control study of 480 previously validated SJS/TEN cases (1995-2013) we used conditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs), and calculated absolute risks of SJS/TEN within separate cohorts of new users of 28 AEDs...
October 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/29026478/vaginal-reconstruction-for-vaginal-obliteration-secondary-to-stevens-johnson-syndrome-a-case-report-and-review-of-literature
#12
Gokhan Boyraz, Derman Basaran, M Coskun Salman, Nejat Ozgul, Kunter Yuce
Stevens-Johnson syndrome (SJS) is a rare and acute life-threatening condition, which is almost always precipitated by drugs. Genital mucositis in female patients may also be an important cause of long-term morbidity secondary to mucosal scarring. We present the case of a 33-year-old nulligravid woman with distal vaginal synechiae necessitating a surgical approach, which occurred after an episode of SJS. Also, we aimed to review the literature to reveal cases which required surgical management for long-term genital sequelae as well as discuss preventive measures...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28972382/long-term-stability-of-a-camouflage-retreatment-of-an-asymmetric-class-iii-posterior-open-bite-using-sliding-jigs
#13
Dauro Douglas Oliveira, Bruno Franco de Oliveira, Daniel Santos Fonseca Figueiredo, Alberto Nogueira da Gama Antunes, Paulo Isaías Seraidarian
This article reports the camouflage retreatment of an adult patient presenting an asymmetric Class III malocclusion and posterior open bite. Sliding jigs (SJs) associated with intermaxillary elastics were used. The long-term stability of the excellent results suggests that the use of SJs to correct asymmetric posterior occlusions may be effective.
October 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28970488/single-cell-analysis-reveals-sexually-dimorphic-repertoires-of-interferon-%C3%AE-and-il-17a-producing-t-cells-in-salivary-glands-of-sj%C3%A3-gren-s-syndrome-mice
#14
Arun Wanchoo, Alexandria Voigt, Sukesh Sukumaran, Carol M Stewart, Indraneel Bhattacharya, Cuong Q Nguyen
The development of Sjögren's syndrome (SjS) is a dynamic and temporal process with a female predilection. Following the initial influx of immune cells, T cell clusters develop, accelerating the pathology in the salivary glands. Proinflammatory cytokines, IFN-γ and IL-17A, produced by T cells contribute synergistically to the disease. In this study, we examined the sexual dimorphism in cellular infiltrates of the salivary glands by using functional single-cell microengraving analysis. Using high-throughput sequencing, we investigated the clonal diversity of the T cell receptors (TCRs) of infiltrating IFN-γ and IL-17A-producing T cells in male and female SjS-susceptible (SjS(s)) C57BL/6...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28969001/leptin-ob-r-pathway-promotes-il-4-secretion-from-b-lymphocytes-and-induces-salivary-gland-epithelial-cell-apoptosis-in-sj%C3%A3-gren-s-syndrome
#15
Ting Xu, Wen Xie, Yingchun Ma, Shiliang Zhou, Lu Zhang, Jinyun Chen, Mingyuan Cai, Rurong Sun, Peirong Zhang, Shaobo Yu, Zheng Xu, Wanlan Jiang, Min Wu
Sjögren's syndrome (SjS) is a chronic autoimmune epithelitis in which cell apoptosis promotes the formation of inflammatory lesions. We used immunohistochemistry and TUNEL to assay B cell infiltration and apoptosis in salivary gland tissue from 16-week-old NOD/LtJ mice with SjS. In co-cultures of primary salivary glandepithelial cells (SGECs) and spleen B cells, we assessed SGEC viability and apoptosis using CCK8 assays and flow cytometry. ELISAs were employed to assess cytokine levels in culture medium. Leptin protein, leptin receptor (OB-R), pro- and anti-apoptotic proteins, and Jak2/Stat3/ERK signaling molecules were analyzed using western blotting...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28965339/where-does-the-one-repetition-maximum-exist-on-the-force-velocity-relationship-in-squat
#16
Jean Romain Rivière, Jérémy Rossi, Pedro Jimenez-Reyes, Jean-Benoit Morin, Pierre Samozino
The aim was to determine the position of the one-repetition maximum (1RM) squat point on the force-velocity (F-V) relationship obtained during squat jump (SJ). Ten healthy athletes performed a 1RM squat during which ground reaction force and lower-limb extension velocity were measured, and six loaded SJs to determine individual F-V relationship. The goodness of fit of the linear F-V relationship with or without the 1RM point was tested. The vertical and horizontal coordinates were determined relative to the theoretical maximal force (F0) and the highest loaded SJ (load of 44...
October 1, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28963996/is-acetaminophen-associated-with-a-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-analysis-of-the-french-pharmacovigilance-database
#17
Bénédicte Lebrun-Vignes, Claire Guy, Marie-Josèphe Jean-Pastor, Valérie Gras-Champel, Marie Zenut
AIM: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe mostly drug-induced cutaneous reactions. Acetaminophen is an over-the-counter drug used worldwide to treat pain and reduce fever. In 2013, the US Food and Drug Administration informed the public that acetaminophen was associated with a rare risk of SJS/TEN. The aim of the present retrospective study was to analyse reports of acetaminophen as a possible suspect in the development of SJS/TEN from the French Pharmacovigilance Database (FPDB)...
September 30, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28952676/stevens-johnson-syndrome-induced-by-combination-of-lamotrigine-and-valproic-acid-in-a-9-year-old-boy
#18
K Maduemem, A Vatca, T O'Neill, D Buckley
We describe the case history of a 9-year-old boy who developed Stevens-Johnson syndrome (SJS) following concomitant use of valproic acid and lamotrigine. He presented with rash and fever several weeks after introduction of lamotrigine, having been on valproic acid for seizure disorder. SJS happens to be one of the rare adverse reactions of antiepilepsy drugs (AED). Management is mainly supportive with care escalation when necessary because of the significant morbidity.
June 9, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28940568/serum-il-17-in-patients-with-erythema-multiforme-or-stevens-johnson-syndrome-toxic-epidermal-necrolysis-drug-reaction-and-correlation-with-disease-severity
#19
H Morsy, E A Taha, D A Nigm, R Shahin, E M K Youssef
BACKGROUND: There is strong evidence that drug-induced cutaneous eruptions have an immunological component. Interleukin (IL)-17, a proinflammatory cytokine that is predominantly produced by T helper 17 cells, has been linked to various autoimmune and inflammatory diseases. AIM: To measure serum IL-17 levels in patients with cutaneous drug reactions [erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)] in order to study the associations between IL-17 and disease severity...
September 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28932875/-severe-cutaneous-drug-reactions-in-children
#20
REVIEW
M Mockenhaupt
Among severe drug reactions in children, besides Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), a specific form of hypersensitivity syndrome which is nowadays known as "drug reaction with eosinophilia and systemic symptoms" (DRESS) has to be mentioned. Whereas SJS/TEN is considered one reaction entity of different severity, DRESS has to be distinguished from SJS/TEN but also from other severe exanthems due to multiorgan involvement. Although SJS/TEN is generally referred to as a drug reaction, only about 75% of all cases are actually caused by medications and in children it is only about 50%...
October 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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