Yanqing Wang, Farooq Riaz, Wei Wang, Jincheng Pu, Yuanyuan Liang, Zhenzhen Wu, Shengnan Pan, Jiamin Song, Lufei Yang, Youwei Zhang, Huihong Wu, Fang Han, Jianping Tang, Xuan Wang
Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenetic mechanisms contribute to the pathophysiology of SjS by modulating gene expression and genome stability. DNA methylation, a form of epigenetic modification, is the fundamental mechanism that modifies the expression of various genes by modifying the transcriptional availability of regulatory regions within the genome...
2024: Frontiers in Immunology