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Diffusion lung capacity for monoxide carbon

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https://www.readbyqxmd.com/read/28088638/the-dlno-dlco-ratio-physiological-significance-and-clinical-implications
#1
J M B Hughes, A T Dinh-Xuan
DLNO/DLCO directly measures the ratio of the diffusing capacities of the lung for nitric oxide (NO) and carbon monoxide (CO). In terms of the Roughton and Forster, 1957; equation, 1/DL=1/Dm+1/θVc, where Dm is the membrane (Dm) and θVc is the red cell component of the overall diffusing conductance (DL), DLNO mostly reflects the Dm component and DLCO the θVc red cell component. The DLNO/DLCO ratio is positively related to the DmCO/Vc ratio and the CO red cell resistance (1/θCOVc) as a percentage of the total resistance (1/DLCO), independent of the absolute values of DLNO or DLCO...
January 11, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28087341/lung-diffusing-capacity-in-sub-saharan-africans-versus-european-caucasians
#2
Bamodi Simaga, Kevin Forton, Yoshiki Motoji, Robert Naeije, Vitalie Faoro
Single breath measurements of lung diffusing capacity (DL) for carbon monoxide (CO) and nitric oxide (NO) were performed in age-, sex-, weight- and height-matched 32 Sub-Saharan Africans (13 women) and 32 Caucasian Europeans, and repeated in 14 of each group at 80% of maximum exercise capacity. In Africans versus Caucasians respectively, DLNO was 153±31 vs 176±38ml/mmHg/min at rest (P<0.001) and 210±48 vs 241±52ml/mmHg/min at exercise (P<0.01) while hemoglobin-adjusted DLCO was 29±6 vs 34±6ml/mmHg/min at rest (P<0...
January 10, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28086884/transfer-factor-for-carbon-monoxide-in-patients-with-copd-and-diabetes-results-from-the-german-cosyconet-cohort
#3
Kathrin Kahnert, Tanja Lucke, Frank Biertz, Andreas Lechner, Henrik Watz, Peter Alter, Robert Bals, Jürgen Behr, Rolf Holle, Rudolf M Huber, Stefan Karrasch, Beate Stubbe, Margarethe Wacker, Sandra Söhler, Emiel F M Wouters, Claus Vogelmeier, Rudolf A Jörres
BACKGROUND: An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes. METHODS: Data from the initial visit of the German COPD cohort COSYCONET were used for analysis. 2575 patients with complete lung function data were included, among them 358 defined as diabetics with a reported physician diagnosis of diabetes and/or specific medication...
January 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28086844/are-risk-predicting-models-useful-for-estimating-survival-of-patients-with-rheumatoid-arthritis-associated-interstitial-lung-disease
#4
Hanna M Nurmi, Minna K Purokivi, Miia S Kärkkäinen, Hannu-Pekka Kettunen, Tuomas A Selander, Riitta L Kaarteenaho
BACKGROUND: Risk predicting models have been applied in idiopathic pulmonary fibrosis (IPF), but still not validated in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The purpose of this study was to test the suitability of three prediction models as well as individual lung function and demographic factors for evaluating the prognosis of RA-ILD patients. METHODS: Clinical and radiological data of 59 RA-ILD patients was re-assessed...
January 13, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28081341/association-of-neutrophil-lymphocyte-ratio-with-the-degree-ofinterstitial-lung-disease-in-systemic-sclerosis
#5
Nurhan Atilla, Gözde Yıldırım Çetin, Ayşe Balkarlı
BACKGROUND/AIM: Determining the severity of systemic sclerosis related interstitial lung disease (SSc-ILD) is based on clinical and radiological findings, inflammation marker levels, and carbon monoxide diffusing capacity of the lung (DLCO). Recently studies are ongoing for objective and easy markers. Neutrophil/lymphocyte ratio (NLR) is shown to be a good marker for inflammation in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and carbon monoxide transfer coefficient (KCO) of SSc-ILD patients...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28060545/safety-and-immunogenicity-of-adenovirus-35-tb-vaccine-candidate-in-adults-with-active-or-previous-tb-a-randomized-trial
#6
Richard N van Zyl-Smit, Aliasgar Esmail, Mary E Bateman, Rodney Dawson, Jonathan Goldin, Eva van Rikxoort, Macaya Douoguih, Maria Grazia Pau, Jerald C Sadoff, J Bruce McClain, Margaret Ann Snowden, Jacqueline Benko, David A Hokey, Kathryn Tucker Rutkowski, Andrew Graves, Barbara Shepherd, Sadritdin Ishmukhamedov, Benjamin M N Kagina, Brian Abel, Willem A Hanekom, Thomas J Scriba, Eric D Bateman
RATIONALE: Administration of tuberculosis vaccines in participants with previous or current pulmonary tuberculosis may have the potential for causing harmful post-vaccination immunological (Koch-type) reactions. OBJECTIVES: To assess the safety and immunogenicity of three dose levels of the AERAS-402 live, replication-deficient adenovirus 35-vectored tuberculosis candidate vaccine, containing three mycobacterial antigens, in individuals with current or previous pulmonary tuberculosis...
January 6, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28053522/do-nanoparticles-provide-a-new-opportunity-for-diagnosis-of-distal-airspace-disease
#7
Jakob Löndahl, Jonas Kf Jakobsson, David M Broday, H Laura Aaltonen, Per Wollmer
There is a need for efficient techniques to assess abnormalities in the peripheral regions of the lungs, for example, for diagnosis of pulmonary emphysema. Considerable scientific efforts have been directed toward measuring lung morphology by studying recovery of inhaled micron-sized aerosol particles (0.4-1.5 µm). In contrast, it is suggested that the recovery of inhaled airborne nanoparticles may be more useful for diagnosis. The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28049168/2017-ers-ats-standards-for-single-breath-carbon-monoxide-uptake-in-the-lung
#8
Brian L Graham, Vito Brusasco, Felip Burgos, Brendan G Cooper, Robert Jensen, Adrian Kendrick, Neil R MacIntyre, Bruce R Thompson, Jack Wanger
This document provides an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. Although both DLCO (diffusing capacity) and TLCO (transfer factor) are valid terms to describe the uptake of carbon monoxide in the lung, the term DLCO is used in this document. A joint taskforce appointed by the ERS and ATS reviewed the recent literature on the measurement of DLCO and surveyed the current technical capabilities of instrumentation being manufactured around the world...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28038794/prognostic-role-of-exhaled-breath-condensate-ph-and-fraction-exhaled-nitric-oxide-in-systemic-sclerosis-related-interstitial-lung-disease
#9
Alfredo Guillen-Del Castillo, Sara Sánchez-Vidaurre, Carmen P Simeón-Aznar, María J Cruz, Vicente Fonollosa-Pla, Xavier Muñoz
INTRODUCTION: Interstitial lung disease (ILD) is one of the major causes of death in systemic sclerosis (SSc). This study investigated exhaled breath (EB) and exhaled breath condensate (EBC) biomarkers in patients with SSc and analyzed their role as a prognostic tool in SSc-related ILD. METHODS: Fraction exhaled nitric oxide (FeNO) and exhaled carbon monoxide (eCO) measured in EB, together with pH, nitrite, nitrate and interleukin-6 levels measured in EBC were prospectively analyzed in 35 patients with SSc...
December 27, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28038680/changes-in-plasma-cxcl4-levels-are-associated-with-improvements-in-lung-function-in-patients-receiving-immunosuppressive-therapy-for-systemic-sclerosis-related-interstitial-lung-disease
#10
Elizabeth R Volkmann, Donald P Tashkin, Michael D Roth, Philip J Clements, Dinesh Khanna, Daniel E Furst, Maureen Mayes, Julio Charles, Chi-Hong Tseng, Robert M Elashoff, Shervin Assassi
BACKGROUND: Increased circulatory levels of the chemokine CXCL4 have been associated with the presence of interstitial lung disease (ILD) in an observational study of patients with systemic sclerosis (SSc). The purpose of the present study was to evaluate the relationship between baseline CXCL4 level and extent of ILD in the context of a randomized controlled trial and to determine whether changes in CXCL4 levels in response to immunosuppression are associated with future progression of SSc-ILD...
December 30, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28028682/interstitial-lung-disease-increases-mortality-in-systemic-sclerosis-patients-with-pulmonary-arterial-hypertension-without-affecting-hemodynamics-and-exercise-capacity
#11
M Michelfelder, M Becker, A Riedlinger, E Siegert, D Drömann, X Yu, F Petersen, G Riemekasten
Published data suggest that coexisting interstitial lung disease (ILD) has an impact on mortality in patients with systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH), but there is scarce knowledge if this is reflected by hemodynamics, exercise capacity, autoantibody profile, or pulmonary function. In this partially retrospective study, 27 SSc-PAH patients were compared to 24 SSc-PAH patients with coexisting ILD respecting to survival, pulmonary function, hemodynamics, exercise capacity, and laboratory parameters...
December 27, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/28018523/long-term-outcomes-of-stereotactic-body-radiation-therapy-sbrt-with-fiducial-tracking-for-inoperable-stage-i-non-small-cell-lung-cancer-nsclc
#12
Jonathan W Lischalk, Stephanie M Woo, Shaan Kataria, Nima Aghdam, Ima Paydar, Michael C Repka, Eric D Anderson, Brian T Collins
BACKGROUND: Stereotactic body radiation therapy (SBRT) for stage I non-small cell lung cancer (NSCLC) is considered standard of care in the medically inoperable patient population. Multiple methods of SBRT delivery exist including fiducial-based tumor tracking, which allows for smaller treatment margins and avoidance of patient immobilization devices. We explore the long-term clinical outcomes of this novel fiducial-based SBRT method. METHODS: In this single institutional retrospective review, we detail the outcomes of medically inoperable pathologically confirmed stage I NSCLC...
2016: Journal of Radiation Oncology
https://www.readbyqxmd.com/read/28013060/the-blood-transfer-conductance-for-nitric-oxide-infinite-vs-finite-%C3%AE-no
#13
Kirsten E Coffman, Steven C Chase, Bryan J Taylor, Bruce D Johnson
Whether the specific blood transfer conductance for nitric oxide (NO) with hemoglobin (θNO) is finite or infinite is controversial but important in the calculation of alveolar capillary membrane conductance (DmCO) and pulmonary capillary blood volume (VC) from values of lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO). In this review, we discuss the background associated with θNO, explore the resulting values of DmCO and VC when applying either assumption, and investigate the mathematical underpinnings of DmCO and VC calculations...
December 21, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28012804/improved-cough-and-cough-specific-quality-of-life-in-patients-treated-for-scleroderma-related-interstitial-lung-disease-ssc-ild-results-of-scleroderma-lung-study-ii
#14
Donald P Tashkin, Elizabeth R Volkmann, Chi-Hong Tseng, Michael D Roth, Dinesh Khanna, Daniel E Furst, Philip J Clements, Arthur Theodore, Suzanne Kafaja, Grace Hyun Kim, Jonathan Goldin, Edgar Ariolla, Robert M Elashoff
BACKGROUND: Cough is a common symptom of scleroderma-related interstitial lung disease (SSc-ILD), but its relationship to other characteristics of SSc-ILD, impact on cough-specific QoL and response to therapy for SSc-ILD have not been well studied. METHODS: We investigated frequent cough (FC) in SSc-ILD patients (N=142) enrolled in Scleroderma Lung Study II, a randomized controlled trial comparing mycophenolate mofetil (MMF) and oral cyclophosphamide (CYC) as treatments for ILD...
December 22, 2016: Chest
https://www.readbyqxmd.com/read/28012490/association-of-anti-aminoacyl-transfer-rna-synthetase-antibody-and-anti-melanoma-differentiation-associated-gene-5-antibody-with-the-therapeutic-response-of-polymyositis-dermatomyositis-associated-interstitial-lung-disease
#15
Naomi Yoshida, Masaki Okamoto, Shinjiro Kaieda, Kiminori Fujimoto, Tomohiro Ebata, Morihiro Tajiri, Masayuki Nakamura, Masaki Tominaga, Daisuke Wakasugi, Tomotaka Kawayama, Masataka Kuwana, Tsuneyo Mimori, Hiroaki Ida, Tomoaki Hoshino
BACKGROUND: We attempted to clarify whether the presence of anti-aminoacyl-transfer RNA synthetase antibody (anti-ARS Ab) or anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) is associated with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). METHODS: We retrospectively investigated 22 patients with PM/DM-ILD (10 positive for anti-ARS Ab and nine positive for anti-MDA5 Ab) for whom antibody analysis of conserved serum was possible...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28002595/matrix-metalloproteinase-gene-polymorphisms-and-susceptibility-to-systemic-sclerosis
#16
T F Rech, S B C Moraes, M Bredemeier, J de Paoli, J C T Brenol, R M Xavier, J A B Chies, D Simon
The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components are degraded by matrix metalloproteinases (MMP). Promoter region polymorphisms in MMP genes may influence gene expression, resulting in an imbalance between ECM protein production and degradation. Here, we analyzed MMP1 -1607 1G/2G (rs1799750), MMP3 -1171 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms in relation to susceptibility to SSc and its clinical features...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27987250/lung-disease-severity-in-idiopathic-pulmonary-fibrosis-is-more-strongly-associated-with-impedance-measures-of-bolus-reflux-than-ph-parameters-of-acid-reflux-alone
#17
S Gavini, L F Borges, R T Finn, W-K Lo, H J Goldberg, R Burakoff, N Feldman, W W Chan
BACKGROUND: Gastroesophageal reflux (GER) has been associated with idiopathic pulmonary fibrosis (IPF). Pathogenesis may be related to chronic micro-aspiration. We aimed to assess objective measures of GER on multichannel intraluminal impedance and pH study (MII-pH) and their relationship with pulmonary function testing (PFT) results, and to compare the performance of pH/acid reflux parameters vs corresponding MII/bolus parameters in predicting pulmonary dysfunction in IPF. METHODS: This was a retrospective cohort study of IPF patients undergoing prelung transplant evaluation with MII-pH off acid suppression, and having received PFT within 3 months...
December 16, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27976661/an-approach-to-interpreting-restrictive-spirometric-pattern-results-in-occupational-settings
#18
Federica Tafuro, Massimo Corradi
OBJECTIVES: The aim of this review is to provide an updated overview of definition, epidemiology, diagnostic algorithm and occupational exposures related to abnormal restrictive spirometrical pattern (RSP) in order to improve the correct interpretation of spirometry test results by occupational healthcare providers. METHODS: A review of the scientific English literature of the last 25 years was carried out with MEDLINE and related keywords [(restricti* AND spirometr*) AND occupational]...
December 13, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27958346/clinical-association-of-chemokine-c-x-c-motif-ligand-1-cxcl1-with-interstitial-pneumonia-with-autoimmune-features-ipaf
#19
Minrui Liang, Zhixing Jiang, Qiong Huang, Lei Liu, Yu Xue, Xiaoxia Zhu, Yiyun Yu, Weiguo Wan, Haihua Yang, Hejian Zou
The term "interstitial pneumonia with autoimmune features" (IPAF) has been recently proposed. We here investigate the clinical characteristics of IPAF and evaluate the clinical implications of CXCL1-CXCR2 axis in IPAF. An increased plasma level of CXCL1 was exhibited in IPAF compared to idiopathic interstitial pneumonia (IIP), chronic obstructive pulmonary disease (COPD), and healthy controls. Additionally, plasma CXCL1 levels were clinically associated with diffusing capacity of the lungs for carbon monoxide (DLCO), erythrocyte sedimentation rate (ESR), and involved parenchyma extension in IPAF...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27941393/use-of-rosuvastatin-in-hiv-associated-chronic-obstructive-pulmonary-disease-a-randomized-pilot-study
#20
Alison Morris, Meghan Fitzpatrick, Marnie Bertolet, Shulin Qin, Lawrence Kingsley, Nicolas Leo, Cathy Kessinger, Heather Michael, Deborah Mcmahon, Rene Weinman, Stephen Stone, Joseph K Leader, Eric Kleerup, Laurence Huang, Stephen R Wisniewski
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is more prevalent in HIV-infected individuals and is associated with persistent inflammation. Therapies unique to HIV are lacking. We performed a pilot study of the HMG Co-A reductase inhibitor rosuvastatin to determine effects on lung function. DESIGN: Randomized, placebo-controlled, triple-blinded trial METHODS:: HIV-infected individuals with abnormal lung function were recruited from an ongoing lung function study...
December 8, 2016: AIDS
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