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https://www.readbyqxmd.com/read/27910496/design-of-a-dispersion-interferometer-combined-with-a-polarimeter-to-increase-the-electron-density-measurement-reliability-on-iter
#1
T Akiyama, A Sirinelli, C Watts, P Shigin, G Vayakis, M Walsh
A dispersion interferometer is a reliable density measurement system and is being designed as a complementary density diagnostic on ITER. The dispersion interferometer is inherently insensitive to mechanical vibrations, and a combined polarimeter with the same line of sight can correct fringe jump errors. A proof of the principle of the CO2 laser dispersion interferometer combined with the PEM polarimeter was recently conducted, where the phase shift and the polarization angle were successfully measured simultaneously...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909126/medium-term-outcomes-of-the-universal-2-total-wrist-arthroplasty-in-patients-with-rheumatoid-arthritis
#2
R Badge, K Kailash, D R Dickson, S Mahalingam, A Raza, A Birch, D Nuttall, S R Murali, M J Hayton, S Talwalkar, A C Watts, I A Trail
AIMS: The aims of this study were to evaluate the clinical and radiological outcomes of the Universal-2 total wrist arthroplasty (TWA) in patients with rheumatoid arthritis. PATIENTS AND METHODS: This was a retrospective review of all 95 Universal-2 TWAs which were performed in our institution between 2003 to 2012 in patients with rheumatoid arthritis. A total of six patients were lost to follow-up and two died of unrelated causes. A total of ten patients had bilateral procedures...
December 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27908251/effects-of-an-outpatient-service-rehabilitation-programme-in-patients-affected-by-pulmonary-arterial-hypertension-an-observational-study
#3
Maurizio Bussotti, Paola Gremigni, Roberto Fe Pedretti, Patrycja Kransinska, Silvia Di Marco, Paola Corbo, Giovanni Marchese, Paolo Totaro, Marinella Sommaruga
BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare disease characterised by a severe impairment of functional status and quality of life (QoL). Use of rehabilitative programmes may help to improve outcomes. The aim of this pre/post test case series was to evaluate the impact of a training program, including sessions of aerobic and resistance exercise, inspiratory muscle reinforcement, slow breathing, relaxation, and psychological support, on functional outcomes. METHODS: Fifteen patients affected by PAH, in World Health Organization (WHO) Functional Class (FC) II or III and in stable clinical condition, were included in a 4-week cardiorespiratory training programme conducted in outpatient service...
November 30, 2016: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/27906491/influence-of-alcohol-%C3%AE-fluorination-on-hydrogen-bond-acidity-of-conformationally-flexible-substrates
#4
Jerome Graton, Guillaume Compain, François Besseau, Elena Bogdan, Joe Watts, Lewis Mtashobya, Zhong Wang, Alex Weymouth-Wilson, Nicolas Galland, Jean-Yves Le Questel, Bruno Linclau
Rational modulations of molecular interactions are of significant importance in compound properties optimization. We have previously shown that fluorination of conformationally rigid cyclohexanols leads to attenuation of their hydrogen-bond (H-bond) donating capacity (pKAHY) when OH***F intramolecular hydrogen-bond (IMHB) interactions occur, as opposed to an increase in pKAHY due to the fluorine electronegativity. This work has now been extended to a wider range of aliphatic β-fluorohydrins with increasing degrees of conformational flexibility...
December 1, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27901269/ability-of-independently-ambulant-children-with-cerebral-palsy-to-ride-a-two-wheel-bicycle-a-case-control-study
#5
Rachel Toovey, Susan M Reid, Barry Rawicki, Adrienne R Harvey, Kerrianne Watt
AIM: Limited information exists on the ability of children with cerebral palsy (CP) to ride a two-wheel bicycle, an activity that may improve health and participation. We aimed to describe bicycle-riding ability and variables associated with ability to ride in children with CP (Gross Motor Functional Classification System [GMFCS] levels I-II) compared with children with typical development. METHOD: This case-control study surveyed parents of 114 children with CP and 87 children with typical development aged 6 to 15 years (115 males, mean age 9y 11mo, standard deviation [SD] 2y 10mo)...
November 30, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27899894/moderate-load-eccentric-exercise-a-distinct-novel-training-modality
#6
REVIEW
Hans Hoppeler
Over the last 20 years a number of studies have been published using progressive eccentric exercise protocols on motorized ergometers or similar devices that allow for controlled application of eccentric loads. Exercise protocols ramp eccentric loads over an initial 3 weeks period in order to prevent muscle damage and delayed onset muscle soreness. Final training loads reach 400-500 W in rehabilitative settings and over 1200 W in elite athletes. Training is typically carried out three times per week for durations of 20-30 min...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27899531/a-respiratory-therapist-disease-management-program-for-patients-hospitalized-with-copd
#7
Patty C Silver, Marin H Kollef, Darnetta Clinkscale, Peggy Watts, Robin Kidder, Brittany Eads, Debbie Bennett, Carolyn Lora, Michael Quartaro
BACKGROUND: Patients with COPD often require repeated emergency department visits and hospitalizations for COPD exacerbations. Such readmissions increase health-care costs and expose COPD patients to the added risks of nosocomial infections and increased mortality. METHODS: To determine whether a respiratory therapist (RT) disease management program could reduce re-hospitalization and emergency department visits, a prospective, single-center, unblinded, randomized trial was performed...
November 29, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27899400/study-protocol-a-phase-iii-randomised-double-blind-parallel-arm-stratified-block-randomised-placebo-controlled-trial-investigating-the-clinical-effect-and-cost-effectiveness-of-sertraline-for-the-palliative-relief-of-breathlessness-in-people-with-chronic-breathlessness
#8
Gareth J Watts, Katherine Clark, Meera Agar, Patricia M Davidson, Christine McDonald, Lawrence T Lam, Dimitar Sajkov, Nicola McCaffrey, Matthew Doogue, Amy P Abernethy, David C Currow
INTRODUCTION: Breathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27896016/wide-field-fourier-ptychographic-microscopy-using-laser-illumination-source
#9
Jaebum Chung, Hangwen Lu, Xiaoze Ou, Haojiang Zhou, Changhuei Yang
Fourier ptychographic (FP) microscopy is a coherent imaging method that can synthesize an image with a higher bandwidth using multiple low-bandwidth images captured at different spatial frequency regions. The method's demand for multiple images drives the need for a brighter illumination scheme and a high-frame-rate camera for a faster acquisition. We report the use of a guided laser beam as an illumination source for an FP microscope. It uses a mirror array and a 2-dimensional scanning Galvo mirror system to provide a sample with plane-wave illuminations at diverse incidence angles...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27894323/health-related-quality-of-life-and-a-cost-utility-simulation-of-adults-in-the-uk-with-osteogenesis-imperfecta-x-linked-hypophosphatemia-and-fibrous-dysplasia
#10
Lydia Forestier-Zhang, Laura Watts, Alison Turner, Harriet Teare, Jane Kaye, Joe Barrett, Cyrus Cooper, Richard Eastell, Paul Wordsworth, Muhammad K Javaid, Rafael Pinedo-Villanueva
BACKGROUND: Health-related quality of life of adults with osteogenesis imperfecta (OI), fibrous dysplasia (FD) and X-linked hypophosphatemia (XLH) remains poorly described. The aim of this study was to describe the HRQoL of adults with osteogenesis imperfecta, fibrous dysplasia and X-linked hypophophataemia and perform a cost-utility simulation to calculate the maximum cost that a health care system would be willing to pay for a hypothetical treatment of a rare bone disease. RESULTS: Participants completed the EQ-5D-5 L questionnaire between September 2014 and March 2016...
November 28, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27894289/the-patient-reporting-and-action-for-a-safe-environment-prase-intervention-a-feasibility-study
#11
Jane K O'Hara, Rebecca J Lawton, Gerry Armitage, Laura Sheard, Claire Marsh, Kim Cocks, Rosie R C McEachan, Caroline Reynolds, Ian Watt, John Wright
BACKGROUND: There is growing interest in the role of patients in improving patient safety. One such role is providing feedback on the safety of their care. Here we describe the development and feasibility testing of an intervention that collects patient feedback on patient safety, brings together staff to consider this feedback and to plan improvement strategies. We address two research questions: i) to explore the feasibility of the process of systematically collecting feedback from patients about the safety of care as part of the PRASE intervention; and, ii) to explore the feasibility and acceptability of the PRASE intervention for staff, and to understand more about how staff use the patient feedback for service improvement...
November 28, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27893701/the-signaling-adaptor-traf1-negatively-regulates-toll-like-receptor-signaling-and-this-underlies-its-role-in-rheumatic-disease
#12
Ali A Abdul-Sater, Maria I Edilova, Derek L Clouthier, Achire Mbanwi, Elisabeth Kremmer, Tania H Watts
TRAF1 is a signaling adaptor known for its role in tumor necrosis factor receptor-induced cell survival. Here we show that monocytes from healthy human subjects with a rheumatoid arthritis-associated single-nucleotide polymorphism (SNP) in the TRAF1 gene express less TRAF1 protein but greater amounts of inflammatory cytokines in response to lipopolysaccharide (LPS). The TRAF1 MATH domain binds directly to three components of the linear ubiquitination (LUBAC) complex, SHARPIN, HOIP and HOIL-1, to interfere with the recruitment and linear ubiquitination of NEMO...
November 28, 2016: Nature Immunology
https://www.readbyqxmd.com/read/27890522/design-and-challenges-of-a-randomized-clinical-trial-of-medical-expulsive-therapy-tamsulosin-for-urolithiasis-in-the-emergency-department
#13
K Burrows Pamela, E Hollander Judd, B Wolfson Allan, C Kurz Michael, Richards Lorna, DiFiore Sara, Watts Phillip, Patkar Nivedita, Brown Jeremy, Jackman Stephen, Kirkali Ziya, W Kusek John, Michel Chloe, C Meltzer Andrew
Urolithiasis or urinary stone disease has been estimated to affect about 1 in 11 Americans. Patients with urinary stone disease commonly present to the emergency department for management of their acute pain. In addition to providing analgesia, administration of drug (medical expulsive therapy) is often prescribed to assist passage of the urinary stone. In this methodology paper, we describe the design of a prospective, multi-center, randomized, double-blind placebo controlled clinical trial of the alpha-adrenergic blocker, tamsulosin, to evaluate its effectiveness as medical expulsive therapy...
November 23, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27890480/chemerin-induced-arterial-contraction-is-gi-and-calcium-dependent
#14
David J Ferland, Emma S Darios, Richard R Neubig, Benita Sjögren, Nguyen Truong, Rosa Torres, Thomas S Dexheimer, Janice M Thompson, Stephanie W Watts
Chemerin is an adipokine associated with increased blood pressure, and may link obesity with hypertension. We tested the hypothesis that chemerin-induced contraction of the vasculature occurs via calcium flux in smooth muscle cells. Isometric contraction of rat aortic rings was performed in parallel with calcium kinetics of rat aortic smooth muscle cells to assess the possible signaling pathway. Chemerin-9 (nonapeptide of the chemerin S(157) isoform) caused a concentration-dependent contraction of isolated aorta (EC50 100nM) and elicited a concentration-dependent intracellular calcium response (EC50 10nM)...
November 24, 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27889682/-stress-anger-fear-and-injustice-an-international-qualitative-survey-of-women-s-experiences-planning-a-vaginal-breech-birth
#15
Karolina Petrovska, Nicole P Watts, Christine Catling, Andrew Bisits, Caroline Se Homer
OBJECTIVE: the outcomes of the Term Breech Trial had a profound impact on women's options for breech birth, with caesarean section now seen as the default method for managing breech birth by many clinicians. Despite this, the demand for planned vaginal breech birth from women does exist. This study aimed to examine the experiences of women who sought a vaginal breech birth to increase understanding as to how to care for women seeking this birth option. DESIGN: an electronic survey was distributed to women online via social media...
November 21, 2016: Midwifery
https://www.readbyqxmd.com/read/27889294/increasing-the-detection-of-fh-using-general-practice-electronic-databases
#16
Alistair W Vickery, Jackie Ryan, Jing Pang, Jacquie Garton-Smith, Gerald F Watts
BACKGROUND: Familial hypercholesterolaemia (FH) is a common autosomal co-dominant condition that causes premature cardiovascular disease. Awareness of FH is poor and only 10-15% of the affected population is identified. Electronic health records provide an opportunity to increase detection and awareness in general practice OBJECTIVE: To determine whether a simple electronic extraction tool can increase detection of FH in general practice. METHOD: An extraction tool applied to general practice electronic health records (EHR) to screen for FH, total cholesterol and low density lipoprotein cholesterol (LDL-c) levels in association with entered diagnostic criteria and demographic data in five general practices...
November 15, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27888185/registries-codifications-and-cardiovascular-outcomes-in-familial-hypercholesterolaemia
#17
EDITORIAL
Katrina L Ellis, Jing Pang, Gerald F Watts
No abstract text is available yet for this article.
November 25, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27888090/rationale-and-design-of-mi-care-the-mile-square-colorectal-cancer-screening-awareness-and-referral-and-education-project
#18
Joanna Buscemi, Yazmin San Miguel, Lisa Tussing-Humphreys, Elizabeth A Watts, Marian L Fitzgibbon, Karriem Watson, Robert A Winn, Kameron L Matthews, Yamile Molina
Although colorectal cancer (CRC) is largely preventable through identification of pre-cancerous polyps through various screening modalities, morbidity and mortality rates remain a challenge, especially in African-American, Latino, low-income and uninsured/underinsured patients. Barriers to screening include cost, access to health care facilities, lack of recommendation to screen, and psychosocial factors such as embarrassment, fear of the test, anxiety about testing preparation and fear of a cancer diagnosis...
November 22, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27886668/a-new-definition-for-oral-health-developed-by-the-fdi%C3%A2-world-dental-federation-opens-the-door-to-a-universal-definition-of-oral-health
#19
EDITORIAL
Michael Glick, David M Williams, Dushanka V Kleinman, Marko Vujicic, Richard G Watt, Robert J Weyant
No abstract text is available yet for this article.
December 2016: Journal of the American Dental Association
https://www.readbyqxmd.com/read/27885966/er-cr-ysgg-laser-effectively-ablates-single-species-biofilms-on-titanium-disks-without-detectable-surface-damage
#20
Jason M Strever, Jaebum Lee, William Ealick, Mark Peacock, Daniel Shelby, Cristiano Susin, Donald Mettenberg, Ahmed El-Awady, Frederick Rueggeberg, Christopher W Cutler
BACKGROUND: Increasing evidence implicates biofilms, consisting of species such as Porphyromonas gingivalis, in the etiology of peri-implantitis. Multiple approaches to ablate biofilms on failing implants have been proposed, include the use of lasers; most recently the Er,Cr:YSGG laser. The purpose of this study is to establish an in-vitro single-species biofilm model on implant surfaces and determine power settings of the Er,Cr:YSGG laser that remove the biofilm while not causing physical damage to the disk...
November 25, 2016: Journal of Periodontology
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