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Bradley V Watts, Linda Williams, Peter D Mills, Douglas E Paull, Jeffrey A Cully, Stuart C Gilman, Robin R Hemphill
OBJECTIVES: Developing a workforce skilled in improving the safety of medical care has often been cited as an important means to achieve safer care. Although some educational programs geared toward patient safety have been developed, few advanced training programs have been described in the literature. We describe the development of a patient safety fellowship program. METHODS: We describe the development and curriculum of an Interprofessional Fellowship in Patient Safety...
June 15, 2018: Journal of Patient Safety
Adam J Luippold, Nisha Charkoudian, Robert W Kenefick, Scott J Montain, Jason K W Lee, Ya Shi Teo, Samuel N Cheuvront
Background: Fluid intake during military training is prescribed based on the interactions among work rates, environmental conditions, and uniform configurations. The efficacy of this guidance has not been empirically assessed in over a decade. To determine the acceptability of the fluid intake guidance, sweat losses were measured in a variety of conditions with modern uniform/body armor configurations and were then compared to prescribed fluid intakes for each condition (workload, environment, clothing)...
April 18, 2018: Military Medicine
Robert G Lockie, J Jay Dawes, Margaret T Jones
This study investigated relationships that linear speed and lower-body power have on change-of-direction (COD) speed in collegiate women soccer players. Data from two Division I ( n = 39) and one Division II ( n = 18) schools were analyzed. Subjects were assessed in: power (vertical jump (VJ); jump height, peak anaerobic power measured in watts (PAPw), power-to-body mass ratio (P:BM); linear speed (10-m sprint); and COD speed (modified T-test (MTT), 505, COD deficit). Independent samples T-tests derived significant between-group differences, with effect sizes ( d ) calculated...
April 4, 2018: Sports (Basel)
Kyle Y Xu, Andrew J Watt
The anterolateral thigh (ALT) flap is a viable and reliable option for phalloplasty. The primary advantages of the ALT flap remain an inconspicuous donor site and flexibility in phallus length. The disadvantages of the ALT flap are a higher incidence of both flap and urethral complications compared with a radial forearm phalloplasty. Although the ALT phalloplasty can achieve the primary goals of standing micturition, penetrative intercourse, and an aesthetic phallus, multiple stages and revisions are often necessary...
July 2018: Clinics in Plastic Surgery
Qi Bian, Yong Bo, Junwei Zuo, Min Li, Ruoxi Dong, Keran Deng, Dingwen Zhang, Liping He, Qingshuang Zong, Dafu Cui, Qinjun Peng, Hongbin Chen, Zuyan Xu
The brightness of the artificial beacon is one critical performance parameter for adaptive optics. Here, a 40-watt level narrow-linewidth microsecond pulsed yellow laser is produced at 589 nm with a high repetition frequency of 600 Hz and a pulse duration of 120 μs. An experiment to project the pulse beam up to the sky and measure the fluorescence photon returns of the Na atoms has been held on the 1.8-meter telescope in Lijiang observatory. During the sky test, a laser guide star (LGS) spot is firstly observed with Rayleigh scattering elimination by means of a gateable pulse format...
June 15, 2018: Scientific Reports
Stephanie W Watts, Emma S Darios, Adam E Mullick, Hannah Garver, Thomas L Saunders, Elizabeth D Hughes, Wanda E Filipiak, Michael G Zeidler, Nichole McMullen, Christopher J Sinal, Ramya K Kumar, David J Ferland, Gregory D Fink
Measures of the adipokine chemerin are elevated in multiple cardiovascular diseases, including hypertension, but little mechanistic work has been done to implicate chemerin as being causative in such diseases. The chemerin knockout (KO) rat was created to test the hypothesis that removal of chemerin would reduce pressure in the normal and hypertensive state. Western analyses confirmed loss of chemerin in the plasma and tissues of the KO vs. wild-type (WT) rats. Chemerin concentration in plasma and tissues was lower in WT females than in WT males, as determined by Western analysis...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Matthew A Weber, Eric T Graack, Jamie L Scholl, Kenneth J Renner, Gina L Forster, Michael J Watt
Adult psychiatric disorders characterized by cognitive deficits reliant on prefrontal cortex (PFC) dopamine are promoted by teenage bullying. Similarly, male Sprague-Dawley rats exposed to social defeat in mid-adolescence (P35-39) show impaired working memory in adulthood (P56-70), along with decreased medial PFC (mPFC) dopamine activity that results in part from increased dopamine transporter-mediated clearance. Here, we determined if dopamine synthesis and D2 autoreceptor-mediated inhibition of dopamine release in the adult mPFC are also enhanced by adolescent defeat to contribute to later dopamine hypofunction...
June 14, 2018: European Journal of Neuroscience
Sarah Dennis, Ian Watts, Ying Pan, Helena Britt
QUESTIONS: Which health problems do medical general practitioners (GPs) most commonly refer to physiotherapists? What is the likelihood of GPs referring patients for specific health problems? DESIGN: Secondary analysis of data from the Bettering the Evaluation and Care of Health (BEACH) study, which is a national observational study of Australian general practice clinical activity. PARTICIPANTS: People at GP encounters between April 2010 and March 2015...
June 11, 2018: Journal of Physiotherapy
Gordon P Watt, Miryoung Lee, Jen-Jung Pan, Michael B Fallon, Rohit Loomba, Laura Beretta, Joseph B McCormick, Susan P Fisher-Hoch
BACKGROUND & AIMS: Hepatic fibrosis is a primary risk factor for cirrhosis and hepatocellular carcinoma, which affect a disproportionate number of Hispanics in the United States. We aimed to determine the prevalence of significant fibrosis, measured by point shear-wave elastography (pSWE), and determine characteristics of hepatic fibrosis and simple steatosis in a population-based study of Mexican American Hispanics in south Texas. METHODS: Liver stiffness was measured by pSWE, performed by 2 separate operators, for 406 participants in the Cameron County Hispanic Cohort from 2015 through 2017...
June 11, 2018: Clinical Gastroenterology and Hepatology
Roberto Fallica, Benjamin Watts, Benedikt Roesner, Gioia Della Giustina, Laura Brigo, Giovanna Brusatin, Yasin Ekinci
We report on the near edge X-ray absorption fine structure (NEXAFS) spectroscopy of hybrid organic-inorganic resists. These materials are nonchemically amplified systems based on Si, Zr, and Ti oxides, synthesized from organically modified precursors and transition metal alkoxides by a sol-gel route and designed for ultraviolet, extreme ultraviolet and electron beam lithography. The experiments were conducted using a scanning transmission X-ray microscope (STXM) which combines high spatial-resolution microscopy and NEXAFS spectroscopy...
June 14, 2018: Nanotechnology
Vivek Kumar Sharma, Maire F Osborn, Matthew Hassler, Dimas Echeverria, Socheata Ly, Egor Ulashchik, Yury Martynenko-Makaev, Vadim V Shmanai, Timofei S Zatsepin, Anastasia Khvorova, Jonathan Watts
GalNAc conjugation is emerging as a dominant strategy for delivery of therapeutic oligonucleotides to hepatocytes. The structure and valency of the GalNAc ligand contributes to the potency of the conjugates. Here we present a panel of multivalent GalNAc variants using two different synthetic strategies. Specifically, we present a novel conjugate based on a support-bound trivalent GalNAc cluster, and three others using a GalNAc phosphoramidite monomer that was readily assembled into tri- or tetravalent designs during solid phase oligonucleotide synthesis...
June 13, 2018: Bioconjugate Chemistry
Sarah M Greenblatt, Na Man, Pierre-Jacques Hamard, Takashi Asai, Daniel Karl, Concepcion Martinez, Daniel Bilbao, Vasileios Stathais, Anna McGrew-Jermacowicz, Stephanie Duffort, Madhavi Tadi, Ezra Blumenthal, Samantha Newman, Ly Vu, Ye Xu, Fan Liu, Stephan C Schurer, Michael T McCabe, Ryan G Kruger, Mingjiang Xu, Feng-Chun Yang, Daniel Tenen, Justin Watts, Francisco Vega, Stephen D Nimer
Chromatin-modifying enzymes, and specifically the protein arginine methyltransferases (PRMTs), have emerged as important targets in cancer. Here, we investigated the role of CARM1 in normal and malignant hematopoiesis. Using conditional knockout mice, we show that loss of CARM1 has little effect on normal hematopoiesis. Strikingly, knockout of Carm1 abrogates both the initiation and maintenance of acute myeloid leukemia (AML) driven by oncogenic transcription factors. We show that CARM1 knockdown impairs cell-cycle progression, promotes myeloid differentiation, and ultimately induces apoptosis...
June 11, 2018: Cancer Cell
Geoff Watts
No abstract text is available yet for this article.
June 2, 2018: Lancet
Elisabetta Maria Zanetti, Stefano Ciaramella, Michele Calì, Giulia Pascoletti, Massimo Martorelli, Riccardo Asero, David C Watts
OBJECTIVE: To investigate the influence of implant design on the change in the natural frequency of bone-implant system during osseointegration by means of a modal 3D finite element analysis. METHODS: Six implants were considered. Solid models were obtained by means of reverse engineering techniques. The mandibular bone geometry was built-up from a CT scan dataset through image segmentation. Each implant was virtually implanted in the mandibular bone. Two different models have been considered, differing in the free length of the mandibular branch ('long branch' and 'short branch') in order to simulate the variability of boundary conditions when performing vibrometric analyses...
June 8, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Eric Surrey, Hugh S Taylor, Linda Giudice, Bruce A Lessey, Mauricio S Abrao, David F Archer, Michael P Diamond, Neil P Johnson, Nelson B Watts, J Chris Gallagher, James A Simon, Bruce R Carr, W Paul Dmowski, Nicholas Leyland, Sukhbir S Singh, Tomasz Rechberger, Sanjay K Agarwal, W Rachel Duan, Brittany Schwefel, James W Thomas, Paul M Peloso, Juki Ng, Ahmed M Soliman, Kristof Chwalisz
OBJECTIVE: To evaluate the efficacy and safety of elagolix, an oral, nonpeptide gonadotropin-releasing hormone antagonist, over 12 months in women with endometriosis-associated pain. METHODS: Elaris Endometriosis (EM)-III and -IV were extension studies that evaluated an additional 6 months of treatment after two 6-month, double-blind, placebo-controlled phase 3 trials (12 continuous treatment months) with two elagolix doses (150 mg once daily and 200 mg twice daily)...
June 6, 2018: Obstetrics and Gynecology
Philip A Spechler, Nicholas Allgaier, Bader Chaarani, Robert Whelan, Richard Watts, Catherine Orr, Matthew D Albaugh, Nicholas D'Alberto, Stephen T Higgins, Kelsey E Hudson, Scott Mackey, Alexandra Potter, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Michael N Smolka, Henrik Walter, Gunter Schumann, Robert R Althoff, Hugh Garavan
Cannabis use initiated during adolescence might precipitate negative consequences in adulthood. Thus, predicting adolescent cannabis use prior to any exposure will inform the etiology of substance abuse by disentangling predictors from consequences of use. In this prediction study, data were drawn from the IMAGEN sample, a longitudinal study of adolescence. All selected participants (n=1,581) were cannabis-naïve at age 14. Those reporting any cannabis use (out of 6 ordinal use levels) by age 16 were included in the outcome group (N=365, males n=207)...
June 11, 2018: European Journal of Neuroscience
Andressa B Peregrino, Richard G Watt, Anja Heilmann, Stephen Jivraj
Breastfeeding is an important public health issue worldwide. Breastfeeding rates in the United Kingdom, particularly for exclusive breastfeeding, are low compared with other OECD countries, despite its wide-ranging health benefits for both mother and child. There is evidence that deprivation in the structural and social organisation of neighbourhoods is associated with adverse child outcomes. This study aimed to explore whether breastfeeding initiation, exclusive breastfeeding for at least 3 months, and any type of breastfeeding for at least 6 months were associated with neighbourhood context measured by neighbourhood deprivation and maternal neighbourhood perceptions in a nationally representative U...
June 11, 2018: Maternal & Child Nutrition
Gerald F Watts, Richard Norman
No abstract text is available yet for this article.
June 2, 2018: International Journal of Cardiology
Wolfgang Langhans, Roger Adan, Myrtha Arnold, William A Banks, J Patrick Card, Megan J Dailey, Derek Daniels, Annette D de Kloet, Guillaume de Lartigue, Suzanne Dickson, Shahana Fedele, Harvey J Grill, John-Olov Jansson, Sharon Kaufman, Grant Kolar, Eric Krause, Shin J Lee, Christelle Le Foll, Barry E Levin, Thomas A Lutz, Abdelhak Mansouri, Timothy H Moran, Gustavo Pacheco-López, Deepti Ramachandran, Helen Raybould, Linda Rinaman, Willis K Samson, Graciela Sanchez-Watts, Randy J Seeley, Karolina P Skibicka, Dana Small, Alan C Spector, Kellie L Tamashiro, Brian Templeton, Stefan Trapp, Patrick Tso, Alan G Watts, Nadja Weissfeld, Diana Williams, Christian Wolfrum, Gina Yosten, Stephen C Woods
No abstract text is available yet for this article.
May 12, 2018: Molecular Metabolism
Monica Sathyanesan, Michael J Watt, Jacob M Haiar, Jamie L Scholl, Shaydel R Davies, Riley T Paulsen, Jayme Wiederin, Pawel Ciborowski, Samuel S Newton
Cognitive deficits are widespread in psychiatric disorders and frequently as debilitating as the affective component. Widely prescribed antidepressants for treating depressive disorders have limited efficacy in normalizing cognitive function. Erythropoietin (Epo) has been shown to improve cognitive function in schizophrenia and treatment resistant depressed patients. However, the potent elevation of red blood cell counts by Epo can cause hematological complications in non-anemic patients. We investigated a chemically engineered, posttranslational modification of Epo, carbamoylation, which renders it non-erythropoietic...
June 8, 2018: Translational Psychiatry
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