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https://www.readbyqxmd.com/read/29049910/an-improved-synchronization-likelihood-method-for-quantifying-neuronal-synchrony
#1
Sina Khanmohammadi
Indirect quantification of the synchronization between two dynamical systems from measured experimental data has gained much attention in recent years, especially in the computational neuroscience community where the exact model of the neuronal dynamics is unknown. In this regard, one of the most promising methods for quantifying the interrelationship between nonlinear non-stationary systems is known as Synchronization Likelihood (SL), which is based on the likelihood of the auto-recurrence of embedding vectors (similar patterns) in multiple dynamical systems...
October 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29048216/thermal-response-to-high-power-holmium-laser-lithotripsy
#2
Ali H Aldoukhi, Khurshid R Ghani, Timothy L Hall, William W Roberts
OBJECTIVES: The aim of this study was to investigate "calyceal" fluid temperature changes during holmium laser activation/lithotripsy using settings up to 40 watt power output with different irrigation flow rates. METHODS: The experimental system consisted of a glass test tube (diameter 10 mm/length 75 mm) filled with deionized water, to mimic a calyx. Real time temperature was recorded using a thermocouple (Physitemp, NJ) positioned 5 mm from the bottom of the tube...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29047436/jiang-baoguo-one-two-three-against-trauma-in-china
#3
Geoff Watts
No abstract text is available yet for this article.
October 14, 2017: Lancet
https://www.readbyqxmd.com/read/29045736/clinical-trial-parameters-that-influence-outcomes-in-lupus-trials-that-use-the-systemic-lupus-erythematosus-responder-index
#4
Kenneth C Kalunian, Murray B Urowitz, David Isenberg, Joan T Merrill, Michelle Petri, Richard A Furie, Mary-Ann Morgan-Cox, Rebecca Taha, Steven Watts, Maria Silk, Matthew D Linnik
Objective: The SLE Responder Index (SRI) is a composite endpoint used in SLE trials. This investigation examined the clinical trial elements that drive response measured by the SRI. Methods: Analyses are based on data from two phase 3 trials (n = 2262) that evaluated the impact of an anti-B-cell activating factor antibody on disease activity using SRI-5 as the primary endpoint (ClinicalTrials.gov NCT01196091 and NCT01205438). Results: The SRI-5 response rate at week 52 for all patients was 32...
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29044705/subchondral-trabecular-rod-loss-and-plate-thickening-in-the-development-of-osteoarthritis
#5
Yan Chen, Yizhong Hu, Y Eric Yu, Xingjian Zhang, Tezita Watts, Bin Zhou, Ji Wang, Ting Wang, Weiwei Zhao, Kwong Yuen Chiu, Frankie K L Leung, Xu Cao, William W Lu, William Macaulay, Kyle K Nishiyama, Elizabeth Shane, X Edward Guo
Developing effective treatment for osteoarthritis (OA), a prevalent and disabling disease, has remained a challenge, primarily due to limited understanding of its pathogenesis and late diagnosis. In the subchondral bone, rapid bone loss following traumatic injuries and bone sclerosis at the advanced stage of OA are well-recognized hallmarks of the disease. Recent studies have further demonstrated the crucial contribution of subchondral bone in the development of OA. However, the microstructural basis of these bone changes has not been examined thoroughly, and the paradox of how abnormal resorption can eventually lead to bone sclerosis remains unanswered...
October 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29044186/an-endophytic-microbe-from-an-unusual-volcanic-swamp-corn-seeks-and-inhabits-root-hair-cells-to-extract-rock-phosphate
#6
Hanan R Shehata, Christopher Dumigan, Sophia Watts, Manish N Raizada
In the animal microbiome, localization of microbes to specific cell types is well established, but there are few such examples within the plant microbiome which includes endophytes. Endophytes are non-pathogenic microbes that inhabit plants. Root hairs are single cells, equivalent to the nutrient-absorbing intestinal microvilli of animals, used by plants to increase the root surface area for nutrient extraction from soil including phosphorus (P). There has been significant interest in the microbiome of intestinal microvilli but less is known about the root hair microbiome...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044113/large-second-harmonic-generation-enhancement-in-si3n4-waveguides-by-all-optically-induced-quasi-phase-matching
#7
Adrien Billat, Davide Grassani, Martin H P Pfeiffer, Svyatoslav Kharitonov, Tobias J Kippenberg, Camille-Sophie Brès
Efficient second harmonic generation in integrated platforms is usually achieved by resonant structures, intermodal phase-matching or quasi-phase matching by periodically poling ferroelectric waveguides. However, in all these structures, it is impossible to reconfigure the phase-matching condition in an all-optical way. Here, we demonstrate that a Watt-level laser causes a periodic modification of the second-order susceptibility in a silicon nitride waveguide, allowing for quasi-phase-matching between the pump and second harmonic modes for arbitrary wavelengths inside the erbium band...
October 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/29043977/a-protein-phosphatase-network-controls-the-temporal-and-spatial-dynamics-of-differentiation-commitment-in-human-epidermis
#8
Ajay Mishra, Benedicte Oules, Angela Oliveira Pisco, Tony Ly, Kifayathullah Liakath-Ali, Gernot Walko, Priyalakshmi Viswanathan, Matthieu Tihy, Jagdeesh Nijjher, Sara-Jane Dunn, Angus I Lamond, Fiona M Watt
Epidermal homeostasis depends on a balance between stem cell renewal and terminal differentiation. The transition between the two cell states, termed commitment, is poorly understood. Here we characterise commitment by integrating transcriptomic and proteomic data from disaggregated primary human keratinocytes held in suspension to induce differentiation. Cell detachment induces several protein phosphatases, five of which - DUSP6, PPTC7, PTPN1, PTPN13 and PPP3CA - promote differentiation by negatively regulating ERK MAPK and positively regulating AP1 transcription factors...
October 18, 2017: ELife
https://www.readbyqxmd.com/read/29043058/closely-related-octopus-species-show-different-spatial-genetic-structures-in-response-to-the-antarctic-seascape
#9
Jan M Strugnell, A Louise Allcock, Phillip C Watts
Determining whether comparable processes drive genetic divergence among marine species is relevant to molecular ecologists and managers alike. Sympatric species with similar life histories might be expected to show comparable patterns of genetic differentiation and a consistent influence of environmental factors in shaping divergence. We used microsatellite loci to quantify genetic differentiation across the Scotia Arc in three species of closely related benthic octopods, Pareledone turqueti, P. charcoti, and Adelieledone polymorpha...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29042269/the-comparison-of-acute-high-intensity-interval-exercise-vs-continuous-moderate-intensity-exercise-on-plasma-calprotectin-and-associated-inflammatory-mediators
#10
Brandon G Fico, Michael Whitehurst, Aaron L Slusher, James T Mock, Arun Maharaj, Katelyn M Dodge, Chun-Jung Huang
PURPOSE: Calprotectin promotes the release of inflammatory mediators (e.g., monocyte chemoattractant protein-1 [MCP-1] and myeloperoxidase [MPO]) during the innate immune response as a mechanism to augment leukocyte chemotaxis and phagocytosis. Although plasma calprotectin is elevated with traditional continuous moderate-intensity exercise (CME) as an indicator of the inflammatory response, high-intensity interval exercise (HIIE) has been shown to attenuate systemic inflammation while providing similar improvements in cardiovascular health...
October 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29037275/intergenerational-transmission-of-family-meal-patterns-from-adolescence-to-parenthood-longitudinal-associations-with-parents-dietary-intake-weight-related-behaviours-and-psychosocial-well-being
#11
Jerica M Berge, Jonathan Miller, Allison Watts, Nicole Larson, Katie A Loth, Dianne Neumark-Sztainer
OBJECTIVE: The present study examined longitudinal associations between four family meal patterns (i.e. never had regular family meals, started having regular family meals, stopped having regular family meals, maintained having regular family meals) and young adult parents' dietary intake, weight-related behaviours and psychosocial well-being. In addition, family meal patterns of parents were compared with those of non-parents. DESIGN: Analysis of data from the longitudinal Project EAT (Eating and Activity in Adolescents and Young Adults) study...
October 17, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29036383/nigral-stress-induced-dopamine-release-in-clinical-high-risk-and-antipsychotic-na%C3%A3-ve-schizophrenia
#12
Huai-Hsuan Tseng, Jeremy J Watts, Michael Kiang, Ivonne Suridjan, Alan A Wilson, Sylvain Houle, Pablo M Rusjan, Romina Mizrahi
Background: Striatal dopamine (DA) synthesis capacity and release are elevated in schizophrenia (SCZ) and its putative prodrome, the clinical high risk (CHR) state. Striatal DA function results from the activity of midbrain DA neurons projecting mainly from the substantia nigra (SN). Elevated stress-induced DA release in SCZ and CHR was observed in the striatum; however, whether it is also elevated in the SN is unclear. The current study aims to determine whether nigral DA release in response to a validated stress task is altered in CHR and in antipsychotic-naïve SCZ...
June 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29035955/adolescents-decision-to-pursue-bariatric-surgery-a-systematic-review-protocol
#13
Mayra G Garcia, Jennifer L Watt
The objective of this qualitative review is to identify what motivates an adolescent to pursue bariatric surgery.
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035915/the-shape-of-things-to-come-in-lipid-management-a-feast-of-reason
#14
Gerald F Watts, Erik S G Stroes
No abstract text is available yet for this article.
October 13, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29035700/corrigendum-to-hydroxychloroquine-in-hand-oa-results-of-the-uk-hero-trial-osteoarthr-cartil-25-2017-s3-s4
#15
S R Kingsbury, P Tharmanathan, A Keding, S Ronaldson, A Grainger, R Wakefield, C Arundel, F Birrell, M Doherty, T Vincent, F E Watt, K Dziedzic, T O'Neill, N Arden, D L Scott, J Dickson, T Garrood, M Green, A Menon, T Sheeran, D Torgerson, P G Conaghan
No abstract text is available yet for this article.
October 13, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29033859/multi-watt-near-infrared-phototherapy-for-the-treatment-of-comorbid-depression-an-open-label-single-arm-study
#16
Theodore A Henderson, Larry D Morries
BACKGROUND: The treatment of depression has been hampered by low efficacy of antidepressant medications and safety concerns with alternative modalities. Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain injury (TBI). The current objective is to explore multi-Watt NILT efficacy in a proof-of-concept study as a treatment for depression. METHODS: Thirty-nine sequential patients treated for TBI between March 2013 and May 2017 provided depression self-assessment data and/or were administered the Hamilton depression rating scale...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29031468/gunslingers-poker-players-and-chickens-1-decision-making-under-physical-performance-pressure-in-elite-athletes
#17
Beth L Parkin, Katie Warriner, Vincent Walsh
BACKGROUND: The cognitive skills required during sport are highly demanding; accurate decisions based on the processing of dynamic environments are made in a fraction of a second (Walsh, 2014). Optimal decision-making abilities are crucial for success in sporting competition (Bar-Eli et al., 2011; Kaya, 2014). Moreover, for the elite athlete, decision making is required under conditions of intense mental and physical pressure (Anshel and Wells, 2000), yet much of the work in this area has largely ignored the highly stressful context in which athletes operate...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29030619/unwavering-pathobiology-of-volumetric-muscle-loss-injury
#18
Sarah M Greising, Jessica C Rivera, Stephen M Goldman, Alain Watts, Carlos A Aguilar, Benjamin T Corona
Volumetric muscle loss (VML) resulting from extremity trauma presents chronic and persistent functional deficits which ultimately manifest disability. Acellular biological scaffolds, or decellularized extracellular matrices (ECMs), embody an ideal treatment platform due to their current clinical use for soft tissue repair, off-the-shelf availability, and zero autogenous donor tissue burden. ECMs have been reported to promote functional skeletal muscle tissue remodeling in small and large animal models of VML injury, and this conclusion was reached in a recent clinical trial that enrolled 13 patients...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029165/depicting-new-pharmacological-strategies-for-familial-hypercholesterolaemia-involving-lipoprotein-a
#19
Alpo Vuorio, Gerald F Watts, Petri T Kovanen
Approximately 35 million people worldwide suffer from heterozygous familial hypercholesterolaemia (HeFH), a condition characterized by genetically determined life-long elevation of plasma low-density lipoprotein cholesterol (LDL-C). One in three of these patients also inherit an elevated plasma concentration of lipoprotein (a) [Lp(a)], a lipoprotein particle with atherogenic, inflammatory and prothrombotic properties. Accordingly, the combination of high plasma LDL-C and Lp(a) can markedly accelerate premature atherosclerotic cardiovascular disease (ASCVD)...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29028938/impact-of-the-us-maternal-tetanus-diphtheria-and-acellular-pertussis-vaccination-program-on-preventing-pertussis-in-infants-2-months-of-age-a-case-control-evaluation
#20
Tami H Skoff, Amy E Blain, James Watt, Karen Scherzinger, Melissa McMahon, Shelley M Zansky, Kathy Kudish, Paul R Cieslak, Melissa Lewis, Nong Shang, Stacey W Martin
Background: Infants aged <1 year are at highest risk for pertussis-related morbidity and mortality. In 2012, Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) vaccine was recommended for women during each pregnancy to protect infants in the first months of life; data on effectiveness of this strategy are currently limited. Methods: We conducted a case-control evaluation among pertussis cases <2 months old with cough onset between 1 January 2011 and 31 December 2014 from 6 US Emerging Infection Program Network states...
September 28, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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