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sodium picosulfate

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https://www.readbyqxmd.com/read/27859712/feasibility-and-safety-of-bowel-cleansing-using-low-volume-polyethylene-glycol-with-ascorbic-acid-before-pediatric-colonoscopy-a-pilot-study
#1
Tomoyuki Tsunoda, Tsuyoshi Sogo, Kentaro Iwasawa, Shuichiro Umetsu, Manari Oikawa-Kawamoto, Ayano Inui, Tomoo Fujisawa
BACKGROUND AND AIM: To assess the feasibility and safety of same-day regimen of low-volume polyethylene glycol solution with ascorbic acid for bowel cleansing before colonoscopy in children. METHODS: Data on children who received polyethylene glycol solution with ascorbic acid for bowel cleansing in our department were retrospectively analyzed. On the day before the procedure, patients ate a low-residue diet and received sodium picosulfate in the evening. The following day, patients took polyethylene glycol solution with ascorbic acid in the morning; the procedure was carried out in the afternoon...
October 19, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27844063/influence-of-atomic-bonds-on-the-properties-of-the-laxative-drug-sodium-picosulphate
#2
Davide Romani, Isabel Salas Tonello, Silvia Antonia Brandán
In this work, the influence of the different S═O, S-O, N⋯H, O⋯H, Na⋯O bonds present in the structures of the powerful laxative drug, sodium picosulphate in gas and aqueous solution phases were studied combining the density functional theory (DFT) calculations with the experimental available infrared, (1)H NMR and UV-visible spectra. The structural, topological, electronic and vibrational properties were investigated in both media by using the hybrid B3LYP/6-31G* method and the integral equation formalism variant polarised continuum model (IEFPCM)...
November 2016: Heliyon
https://www.readbyqxmd.com/read/27752627/upper-airway-obstruction-resulting-from-acute-mucosal-injury-induced-by-direct-ingestion-of-sodium-picosulfate-magnesium-citrate-powder
#3
Gyeong Bo Kim, Sung Yeon Hwang, Tae Gun Shin, Tae Rim Lee, Won Chul Cha, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong
A 59-year-old man presented to the emergency department with a chief complaint of sore throat after swallowing sodium picosulfate/magnesium citrate powder for bowel preparation, without first dissolving it in water. The initial evaluation showed significant mucosal injury involving the oral cavity, pharynx, and epiglottis. Endotracheal intubation was performed for airway protection in the emergency department, because the mucosal swelling resulted in upper airway compromise. After conservative treatment in the intensive care unit, he underwent tracheostomy because stenosis of the supraglottic and subglottic areas was not relieved...
June 2016: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/27750301/review-prucalopride-velusetrag-bisacodyl-and-sodium-picosulfate-improve-chronic-idiopathic-constipation
#4
Judy Nee, Joseph D Feuerstein
No abstract text is available yet for this article.
October 18, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27732774/acute-gastric-injury-caused-by-undissolved-sodium-picosulfate-magnesium-citrate-powder
#5
Eun Young Ze, Chang Hwan Choi, Jeong Wook Kim
Sodium picosulfate/magnesium citrate (SPMC) is a widely used oral bowel cleansing agent considered to be relatively safe. However, partially dissolved or undissolved SPMC powder may cause severe injuries of the esophagus and stomach. We report a very rare case of acute gastric injury without esophageal damage caused by the ingestion of undissolved SPMC powder. A 69-year-old man experienced epigastric pain after swallowing SPMC powder without dissolving it in water in preparation for a screening colonoscopy...
October 12, 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/27689192/superiority-of-a-split-dose-regimen-of-sodium-picosulfate-magnesium-citrate-spmc-in-comparison-to-a-prior-day-schedule-am-pm-for-colonoscopy-preparation-a-randomized-single-blinded-study
#6
Christian Schulz, Joachim Müller, Joachim Sauter, Stephan Miehlke, Christoph Schmöcker, Dirk Hartmann, Peter Malfertheiner, Carlos Badiola
BACKGROUND AND AIMS: Split-dose regimens are generally recommended for bowel cleansers. However, other regimens still remain in the summary of product characteristics of some bowel cleansers in Europe. The aim of this study is to compare the efficacy and safety of a split-dose regimen of sodium picosulfate/magnesium citrate (SPMC) with a prior-day schedule (AM/PM). METHODS: Multicenter, randomized (EudraCT no. 2013-001620-20), endoscopist-blinded, parallel study, carried out in subjects 18 years or older undergoing elective colonoscopy...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27606043/sensory-characterization-of-bowel-cleansing-solutions
#7
Ala I Sharara, Hamza Daroub, Camille Georges, Rani Shayto, Ralph Nader, Jean Chalhoub, Ammar Olabi
AIM: To evaluate the sensory characteristics of commercial bowel cleansing preparations. METHODS: Samples of 4 commercially available bowel cleansing preparations, namely polyethylene glycol electrolyte solution (PEG), PEG + ascorbic acid (PEG-Asc), sodium picosulfate (SPS), and oral sodium sulfate (OSS) were prepared according to the manufacturer's instructions. Descriptive analysis was conducted (n = 14) using a 15-cm line scale with the Compusense at-hand(®) sensory evaluation software...
August 10, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27559255/specialist-pediatric-palliative-care-prescribing-practices-a-large-5-year-retrospective-audit
#8
Anuja Damani, Naveen Salins, Arunangshu Ghoshal, MaryAnn Muckaden
INTRODUCTION: There is a gradual increasing trend in childhood cancers in India and pediatric palliative care in India is an emerging specialty. Prescribing pain and symptom control drugs in children with cancer requires knowledge of palliative care formulary, dosing schedules, and prescription guidelines. This study is a retrospective audit of prescribing practices of a specialist palliative care service situated in a tertiary cancer center. METHODS: A total of 1135 medication records of children receiving specialist pediatric palliative care services were audited for 5 years (2010-2014) to evaluate prescribing practices in children with advanced cancer...
July 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27487795/safety-and-efficacy-of-a-same-day-low-volume-1%C3%A2-l-peg-bowel-preparation-in-colonoscopy-for-the-elderly-people-and-people-with-renal-dysfunction
#9
Naohisa Yoshida, Yuji Naito, Takaaki Murakami, Ryohei Hirose, Kiyoshi Ogiso, Yutaka Inada, Osamu Dohi, Tetsuya Okayama, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Kewin Tien Ho Siah, Nobuaki Yagi, Yoshito Itoh
INTRODUCTION: A same-day low-volume 1 L polyethylene glycol (PEG) for bowel preparation before colonoscopy was developed to improve patients' compliance. We aimed to evaluate the efficacy and safety of this regimen especially for the elderly and patients with renal dysfunction. METHODS: All consecutive patients who underwent colonoscopy in our center from November 2014 to September 2015 were included. Patients undertook a low-residue diet with 10 mL sodium picosulfate 1 day before colonoscopy...
November 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27451294/lack-of-benefit-of-active-preparation-compared-with-a-clear-fluid-only-diet-in-small-bowel-visualization-for-video-capsule-endoscopy-results-of-a-randomized-blinded-controlled-trial
#10
Lawrence Hookey, Jacob Louw, Michelle Wiepjes, Natalie Rubinger, Stijn Van Weyenberg, Andrew G Day, William Paterson
BACKGROUND AND AIMS: Controversy remains regarding the type and amount of precapsule bowel cleansing required for small-bowel video capsule endoscopy (VCE). This study aims to assess the efficacy and tolerance of 2 active preparations and a control group of clear fluids only. METHODS: Patients with clinical indications for VCE were randomized to (1) clear fluids only the evening before VCE, (2) 2 sachets of sodium picosulfate plus magnesium sulfate (P/MC) the evening before, or (3) 2 L of polyethylene glycol (PEG) the evening before...
July 21, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27298715/low-volume-polyethylene-glycol-with-ascorbic-acid-sodium-picosulfate-magnesium-citrate-and-clear-liquid-diet-alone-prior-to-small-bowel-capsule-endoscopy
#11
Erin Rayner-Hartley, Majid Alsahafi, Paula Cramer, Nazira Chatur, Fergal Donnellan
AIM: To compare low volume polyethylene glycol with ascorbic acid, sodium picosulfate-magnesium citrate and clear liquid diet alone as bowel preparation prior to small bowel capsule endoscopy (CE). METHODS: We retrospectively collected all CE studies done from December 2011 to July 2013 at a single institution. CE studies were reviewed only if low volume polyethylene glycol with ascorbic acid, sodium picosulfate-magnesium citrate or clear liquid diet alone used as the bowel preparation...
June 10, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27087962/the-burden-of-bowel-preparations-in-patients-undergoing-elective-colonoscopy
#12
Ala I Sharara, Zeinab D El Reda, Ali H Harb, Carla G Abou Fadel, Fayez S Sarkis, Jean M Chalhoub, Rachel Abou Mrad
BACKGROUND: An adequate bowel preparation is an important quality measure for optimal colonoscopy. AIMS: The aim of this article is to study the burden of bowel preparations by examining seven specific variables (hunger, taste, volume, sleep, social, work, and adverse events (AEs)). METHODS: Ambulatory patients undergoing elective colonoscopy completed a questionnaire regarding their experience with the prescribed preparation. The seven study variables were graded using a numerical scale of 0-10 (best to worst)...
April 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26986656/more-is-not-always-better-a-randomized-trial-of-low-volume-oral-laxative-enemas-and-combination-of-both-demonstrate-that-enemas-alone-are-most-efficacious-for-preparation-for-flexible-sigmoidoscopy
#13
Lawrence Hookey, Samson Haimanot, Katherine Marchut, Stephen Vanner
OBJECTIVES: Colon cleansing for flexible sigmoidoscopy using a standard fleet enema does not provide adequate cleansing in a significant number of patients. We tested whether the addition of a low-volume oral cleansing agent could mitigate this challenge without significantly compromising patient tolerance. HYPOTHESIS: Oral picosulfate with magnesium citrate (P/MC) would enhance the colon cleansing of patients undergoing sigmoidoscopy, as assessed by the modified Ottawa Bowel Preparation Score...
2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/26973388/combination-could-be-another-tool-for-bowel-preparation
#14
REVIEW
Jae Seung Soh, Kyung-Jo Kim
Optimal bowel preparation increases the cecal intubation rate and detection of neoplastic lesions while decreasing the procedural time and procedural-related complications. Although high-volume polyethylene glycol (PEG) solution is the most frequently used preparation for bowel cleansing, patients are often unwilling to take PEG solution due to its large volume, poor palatability, and high incidence of adverse events, such as abdominal bloating and nausea. Other purgatives include osmotic agents (e.g., sodium phosphate, magnesium citrate, and sodium sulfate), stimulant agents (e...
March 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26945825/polyethylene-glycol-plus-ascorbic-acid-is-as-effective-as-sodium-picosulfate-with-magnesium-citrate-for-bowel-preparation-a-randomized-trial
#15
Hyun-Seok Choi, Jun-Won Chung, Ji Won Lee, Min Young Lim, Dong Kyun Park, Yoon Jae Kim, Kwang Ahn Kwon, Jung Ho Kim
OBJECTIVE: This study was aimed to evaluate the efficacy and safety of two low-volume agents, polyethylene glycol (PEG)-3350 plus ascorbic acid (PEG + Asc) and sodium picosulfate with magnesium citrate (SPMC), for bowel preparation. METHODS: We performed a prospective, endoscopist-blinded, single-center, randomized controlled trial comparing PEG + Asc with SPMC to evaluate the bowel cleansing efficacy of the two regimens using the modified Ottawa bowel preparation scale (OBPS) and the Aronchick scale...
April 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/26886637/phase-ii-randomized-controlled-trial-of-combined-oral-laxatives-medication-for-bowel-preparation-combo-prep-study
#16
RANDOMIZED CONTROLLED TRIAL
Min Jung Kim, Chang Won Hong, Byung Chang Kim, Sung Chan Park, Kyung Su Han, Jungnam Joo, Jae Hwan Oh, Dae Kyung Sohn
The combination of different laxatives at reduced volumes may benefit patients by enhancing efficacy for bowel cleansing and increasing tolerability. However, evidence regarding combined preparations is scarce. This study evaluated whether the combined preparations are associated with enhanced efficacy and tolerability. This randomized phase II study had a single-blind, parallel-arm design. Between December 2013 and September 2014, consecutive patients aged between 20 and 65 years and who required diagnostic colonoscopies were considered for inclusion...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26866689/-treatment-of-chronic-functional-constipation-during-pregnancy-and-lactation
#17
K Gharehbaghi, D R Gharehbaghi, F Wierrani, G Sliutz
Natural fibres (bulk-forming agents), docusate sodium (stool-softener), mineral oils (lubricant laxatives), macrogol (polyethylene glycol, PEG), sugars and sugar alcohols (osmotic laxatives) and anthraquinones and diphenolic laxatives (stimulant laxatives) seem to be safe medicaments regarding teratogenicity and lactation. The US Food and Drug Administration (FDA) risk categories for these substances taken during pregnancy and lactation are often the result of the lack of studies than of evidence-based information...
February 2016: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/26818765/systematic-review-and-meta-analysis-sodium-picosulfate-magnesium-citrate-vs-polyethylene-glycol-for-colonoscopy-preparation
#18
REVIEW
Zheng Jin, Yi Lu, Yi Zhou, Biao Gong
BACKGROUND AND AIMS: Previous studies comparing sodium picosulfate/magnesium citrate (SPMC) with polyethylene glycol (PEG) drew inconsistent conclusions. We conducted a meta-analysis to compare the performance of the two agents for colonoscopy preparation. METHODS: A search of randomized controlled trials (RCTs) up to July 2015 was acquired, using MEDLINE, EMBASE, the Cochrane Library, and Google Scholar. We calculated the pooled estimates of bowel cleanliness, polyp/adenoma detection rate (PDR/ADR), completion of preparation, willingness to repeat identical bowel preparation, and adverse events by using relative risk (RR) with random-effects models...
May 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26634805/increased-risk-of-adverse-renal-outcome-following-polyethylene-glycol-bowel-preparation-compared-to-sodium-picosulfate
#19
Aiden R Liu, Amit X Garg, Kuan Liu, Salimah Z Shariff, Arsh K Jain, Matthew A Weir
No abstract text is available yet for this article.
August 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26272858/split-dose-sodium-picosulfate-magnesium-citrate-colonoscopy-preparation-achieves-lower-residual-gastric-volume-with-higher-cleansing-effectiveness-than-a-previous-day-regimen
#20
César Prieto-Frías, Miguel Muñoz-Navas, María Teresa Betés, Ramón Angós, Susana De la Riva, Cristina Carretero, María Teresa Herraiz, Alejandra Alzina, Luis López
BACKGROUND AND AIMS: It is known that sodium picosulfate-magnesium citrate (SPMC) bowel preparations are effective, well tolerated and safe, and that split-dosing is more effective for colon cleansing than previous-day regimens. Anesthetic guidelines consider that residual gastric fluid is independent of clear liquid fasting times. However, reluctance to use split-dosing persists. This may be due to limited data on residual gastric fluid volumes (RGFVs) and split-dosing bowel preparations, and that these may not be perceived as standard clear liquids...
March 2016: Gastrointestinal Endoscopy
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