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https://www.readbyqxmd.com/read/28072958/-investigation-on-immunization-program-coverage-rate-and-its-safety-in-children-with-tuberous-sclerosis
#1
Y Gao, L P Zou, M N Zhang, L Y Pang, Y Y Wang, S F Ma, L L Huang
Objective: To investigate the status of immunization of National Immunization Program (NIP) and its adverse reaction rate in children with tuberous sclerosis. Method: Questionnaire survey was adopted to identify the vaccination coverage and its adverse events; 72 cases of children with tuberous sclerosis and 78 normal controls (healthy children completing age-appropriate NIP) admitted to Chinese People's Liberation Army General Hospital from December 2014 to November 2015 were involved into this study. Result: The age-appropriate NIP coverage rate of tuberous sclerosis was 36%(26/72)...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28067718/immunogenicity-and-safety-of-a-booster-injection-of-dtap-ipv-hib-pentaxim%C3%A2-administered-concomitantly-with-tetravalent-dengue-vaccine-in-healthy-toddlers-aged-15-to-18-months-in-mexico-a-randomized-trial
#2
Flor Irene Rodriguez Melo, José Juan Renteria Morales, Abiel Homero Mascareñas De Los Santos, Enrique Rivas, Claire Vigne, Fernando Noriega
BACKGROUND: The live, attenuated, tetravalent dengue vaccine (CYD-TDV) is licensed in a number of dengue endemic countries for individuals ≥9 years old. Before integration of any vaccine into childhood vaccination schedules, a lack of immune interference and acceptable safety when co-administered with other recommended vaccines should be demonstrated. METHODS: This randomized, multi-center, Phase III trial was conducted in Mexico. Healthy toddlers (n=732) received a booster dose of a licensed pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, inactivated polio vaccine, and Haemophilus influenzae type b [DTaP-IPV//Hib]) either concomitantly or sequentially with the second dose of CYD-TDV administered as a 3-dose schedule...
January 6, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28067629/standardized-echocardiographic-assessment-of-cardiac-function-in-normal-adult-zebrafish-and-heart-disease-models
#3
Louis W Wang, Inken G Huttner, Celine F Santiago, Scott H Kesteven, Ze-Yan Yu, Michael P Feneley, Diane Fatkin
The zebrafish (Danio rerio) is an increasingly popular model organism in cardiovascular research. Major insights into cardiac developmental processes have been gained by studies of embryonic zebrafish. However, the utility of zebrafish for modeling adult-onset heart disease has been limited by a lack of robust methods for in vivo evaluation of cardiac function. We established a physiological protocol for underwater zebrafish echocardiography using high frequency ultrasound, and evaluated its reliability in detecting altered cardiac function in two disease models...
January 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28065783/mathematical-modeling-of-mutant-transferrin-crm107-molecular-conjugates-for-cancer-therapy
#4
Dennis J Yoon, Kevin Y Chen, André M Lopes, April A Pan, Joseph Shiloach, Anne B Mason, Daniel T Kamei
The transferrin (Tf) trafficking pathway is a promising mechanism for use in targeted cancer therapy due to the overexpression of transferrin receptors (TfRs) on cancerous cells. We have previously developed a mathematical model of the Tf/TfR trafficking pathway to improve the efficiency of Tf as a drug carrier. By using diphtheria toxin (DT) as a model toxin, we found that mutating the Tf protein to change its iron release rate improves cellular association and efficacy of the drug. Though this is an improvement upon using wild-type Tf as the targeting ligand, conjugated toxins like DT are unfortunately still highly cytotoxic at off-target sites...
January 6, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28063725/despite-awareness-of-recommendations-why-do-health-care-workers-not-immunize-pregnant-women
#5
Anat Gesser-Edelsburg, Yaffa Shir-Raz, Samah Hayek, Sharon Aassaraf, Lior Lowenstein
Studies indicate uncertainty surrounding vaccination safety and efficacy for pregnant women, causing a central problem for health authorities. In this study, approximately 26% of participants do not recommend the tetanus, diphtheria, and acellular pertussis and influenza vaccines to their patients, although being aware of the health ministry recommendations. We found significant statistical discrepancies between the knowledge about the recommendations and their actual implementation, revealing the concerns of health care workers regarding vaccine safety...
January 4, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28060909/long-term-depletion-of-conventional-dendritic-cells-cannot-be-maintained-in-an-atherosclerotic-zbtb46-dtr-mouse-model
#6
Miche Rombouts, Nathalie Cools, Mandy O J Grootaert, Flore de Bakker, Ilse Van Brussel, An Wouters, Guido R Y De Meyer, Benedicte Y De Winter, Dorien M Schrijvers
BACKGROUND AND AIMS: Increased evidence suggests a pro-atherogenic role for conventional dendritic cells (cDC). However, due to the lack of an exclusive marker for cDC, their exact contribution to atherosclerosis remains elusive. Recently, a unique transcription factor was described for cDC, namely Zbtb46, enabling us to selectively target this cell type in mice. METHODS: Low-density lipoprotein receptor-deficient (Ldlr-/-) mice were transplanted with bone marrow from Zbtb46-diphtheria toxin receptor (DTR) transgenic mice following total body irradiation...
2017: PloS One
https://www.readbyqxmd.com/read/28043222/public-health-action-following-an-outbreak-of-toxigenic-cutaneous-diphtheria-in-an-auckland-refugee-resettlement-centre
#7
Gary E Reynolds, Helen Saunders, Angela Matson, Fiona O'Kane, Sally A Roberts, Salvin K Singh, Lesley M Voss, Tomasz Kiedrzynski
Global forced displacement has climbed to unprecedented levels due largely to regional conflict. Degraded public health services leave displaced people vulnerable to multiple environmental and infectious hazards including vaccine preventable disease. While diphtheria is rarely notified in New Zealand, a 2 person outbreak of cutaneous diphtheria occurred in refugees from Afghanistan in February 2015 at the refugee resettlement centre in Auckland. Both cases had uncertain immunisation status. The index case presented with a scalp lesion during routine health screen and toxigenic Corynebacterium diphtheriae was isolated...
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28040688/prevalence-of-pertussis-antibodies-in-maternal-blood-cord-serum-and-infants-from-mothers-with-and-those-without-tdap-booster-vaccination-during-pregnancy-in-argentina
#8
Aurelia A Fallo, Silvina E Neyro, Gabriela V Manonelles, Claudia Lara, Daniela Hozbor, Jonathan Zintgraff, Silvina Mazzeo, Héctor E Davison, Susana González, Estella Zapulla, Oscar Canle, Miguel Huespe, Marcelo Galas, Eduardo L López
BACKGROUND: Morbidity and mortality rates for pertussis in infants are high because disease often occurs before the onset of routine immunization or in those who do not complete a primary immunization series. Pertussis immunization is recommended during pregnancy to achieve antibody levels sufficient to protect young infants. To our knowledge, no previous reports of maternal pertussis immunization results in Latin America exist in the literature. METHODS: This study compared pertussis antibody levels in newborns from mothers who received or did not receive a tetanus-diphtheria-acellular pertussis vaccination (TdapV) during pregnancy...
December 30, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28039359/comparing-galactan-biosynthesis-in-mycobacterium-tuberculosis-and-corynebacterium-diphtheriae
#9
Darryl A Wesener, Matthew R Levengood, Laura L Kiessling
The suborder Corynebacterineae encompasses species like Corynebacterium glutamicum, which has been harnessed for industrial production of amino acids, as well as Corynebacterium diphtheriae and Mycobacterium tuberculosis, which cause devastating human diseases. A distinctive component of the Corynebacterineae cell envelope is the mycolyl-arabinogalactan (mAG) complex. The mAG is composed of lipid mycolic acids, and arabinofuranose (Araf) and galactofuranose (Galf) carbohydrate residues. Elucidating microbe-specific differences in mAG composition could advance biotechnological applications and lead to new antimicrobial targets...
December 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28036249/a-novel-alphaherpesvirus-associated-with-fatal-diseases-in-banded-penguins
#10
Florian Pfaff, Christoph Schulze, Patricia König, Kati Franzke, Sabine Bock, Andreas Hlinak, Jens Kämmerling, Andreas Ochs, André Schüle, Thomas C Mettenleiter, Dirk Höper, Martin Beer
A novel avian alphaherpesvirus, preliminarily designated as sphenicid alphaherpesvirus 1 (SpAHV-1) has been independently isolated from juvenile Humboldt and African penguins (Spheniscus humboldti and S. demersus) kept in German zoos suffering from diphtheroid oropharyngitis / laryngotracheitis and necrotizing enteritis (collectively designated as penguin-diphtheria-like disease). High-throughput sequencing was used to determine the complete genome sequences of the first two SpAHV-1 isolates. SpAHV-1 comprises a class D genome with a length of about 164 kbp, a G+C content of 45...
December 30, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/28035954/dmp1-promoter-driven-diphtheria-toxin-receptor-transgene-expression-directs-unforeseen-effects-in-multiple-tissues
#11
Ahmed Al-Jazzar, Behzad Javaheri, Matt Prideaux, Alan Boyde, Cheryl L Scudamore, Chahrazad Cherifi, Eric Hay, Mark Hopkinson, Michael Boyd, Martine Cohen-Solal, Colin Farquharson, Andrew A Pitsillides
Mice harbouring a dentin matrix protein 1 (Dmp1) promoter-driven human diphtheria toxin (DT) receptor (HDTR) transgene (Tg) have recently been used to attain targeted ablation of osteocytes by diphtheria toxin (DT) treatment in order to define osteocyte function. Use of these Tg mice has asserted mechano- and novel paracrine regulatory osteocyte functions. To explore osteocyte roles fully, we sought to confirm the selectivity of DT effects in these transgenic mice. However, our findings revealed incomplete DT-induced osteocyte ablation, prevalent HDTR misexpression, as well as more prominent histopathological DT-induced changes in multiple organs in Tg than in wild-type (WT) littermate mice...
December 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28035545/dtap5-hb-ipv-hib-vaccine-vaxelis-%C3%A2-a-review-of-its-use-in-primary-and-booster-vaccination
#12
Yahiya Y Syed
Vaxelis(®) is a fully liquid, ready-to-use, hexavalent vaccine approved in the EU for primary and booster vaccination in infants and toddlers from the age of 6 weeks against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive diseases caused by Haemophilus influenzae type b (Hib). It contains diphtheria and tetanus toxoids, five acellular pertussis antigens, recombinant hepatitis B virus surface antigen produced in the yeast, Saccharomyces cerevisiae, inactivated poliovirus, and the Hib polysaccharide (polyribosylribitol phosphate) conjugated to the outer membrane protein complex of Neisseria meningitidis...
December 29, 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/28032302/the-1925-diphtheria-antitoxin-run-to-nome-alaska-a-public-health-illustration-of-human-animal-collaboration
#13
Basil H Aboul-Enein, William C Puddy, Jacquelyn E Bowser
Diphtheria is an acute toxin-mediated superficial infection of the respiratory tract or skin caused by the aerobic gram-positive bacillus Corynebacterium diphtheriae. The epidemiology of infection and clinical manifestations of the disease vary in different parts of the world. Historical accounts of diphtheria epidemics have been described in many parts of the world since antiquity. Developed in the late 19th century, the diphtheria antitoxin (DAT) played a pivotal role in the history of public health and vaccinology prior to the advent of the diphtheria-tetanus toxoids and acellular pertussis (DTaP) vaccine...
December 29, 2016: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28030524/attitudes-of-swiss-health-care-providers-towards-childhood-immunizations
#14
Marianne Schuler, Sabine Schaedelin, Christoph Aebi, Christoph Berger, Pierre-Alex Crisinel, Alessandro Diana, Anita Niederer-Loher, Claire-Anne Siegrist, Bernard Vaudaux, Ulrich Heininger
BACKGROUND: INFOVAC is a network providing information about immunization issues to health professionals. The aim of this study was to assess the attitude of INFOVAC subscribers towards the current Swiss immunization schedule, potential modifications, and current and hypothetical immunization practices regarding their own children. METHODS: In March 2015, a web-based survey was sent to 4260 physicians and pharmacists subscribed to INFOVAC. Participation was anonymous and voluntary...
December 27, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28030521/immunogenicity-and-safety-of-10-valent-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv-administered-to-children-with-sickle-cell-disease-between-8-weeks-and-2-years-of-age-a-phase-iii-open-controlled-study
#15
Sodiomon B Sirima, Alfred Tiono, Zakaria Gansané, Mohamadou Siribié, Angèle Zongo, Alphonse Ouédraogo, Nancy François, Ana Strezova, Kurt Dobbelaere, Dorota Borys
BACKGROUND: Immunogenicity, safety and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) were evaluated in children with sickle cell disease (SCD), who are at increased risk for infections. METHODS: In this phase III, open-label, single center, controlled study in Burkina Faso (NCT01175083), children with SCD (S) or without SCD (NS) were assigned to 6 groups (N=300): children 8-11 weeks of age (<6 months; <6S and <6NS groups) received 3 primary doses and a booster dose of PHiD-CV co-administered with routine childhood vaccines; children 7-11 months of age (7-11S and 7-11NS groups) received 2 primary doses and a booster dose of PHiD-CV; children 12-23 months of age (12-23S and 12-23NS groups) received 2 catch-up doses of PHiD-CV...
December 27, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28027283/divergent-memory-b-cell-responses-in-a-mixed-infant-pneumococcal-conjugate-vaccine-schedule
#16
Johannes Trück, Ruth Mitchell, Sena Jawad, Elizabeth A Clutterbuck, Matthew D Snape, Dominic F Kelly, Merryn Voysey, Andrew J Pollard
BACKGROUND: Vaccine-induced immunity against pneumococcal infection relies on the generation of high concentrations of antibody and B-cell memory. Both the 10- and the 13-valent pneumococcal conjugate vaccines (PCV-10 and PCV-13) effectively reduce disease caused by vaccine serotypes. It is unknown whether the generation of B-cell memory requires several doses of the same vaccine or whether different PCVs are interchangeable. METHODS: Children in the UK (n=178) who had previously received PCV-13 at 2 and 4 months were randomized 1:1 to receive a PCV-13 or PCV-10 booster at age 12 months...
December 23, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28017441/extensive-swelling-of-the-limb-and-systemic-symptoms-after-a-fourth-dose-of-acellular-pertussis-containing-vaccines-in-england-in-children-aged-3-6years
#17
Jo Southern, Pauline A Waight, Nick Andrews, Elizabeth Miller
Extensive limb swelling (ESL) after a booster dose of acellular pertussis (aP) containing vaccine can cause concern and has the potential to be confused with cellulitis. In the United Kingdom aP-containing vaccine was introduced for primary immunisation at 2, 3 and 4months of age in 2004, with the first cohorts eligible to receive a fourth dose in 2007 at school entry. We assessed the frequency of ESL (here defined as swelling >100mms diameter) in 973 children receiving a fourth dose of one of four aP vaccines given combined with inactivated polio, tetanus and either low dose diphtheria (TdaP/IPV) or high dose diphtheria (DTaP/IPV) vaccine; 2 of the 3 DTaP/IPV vaccines also contained Haemophilus influenza b conjugate vaccine (Hib)...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/28012347/enhanced-dendritic-morphogenesis-of-adult-hippocampal-newborn-neurons-in-central-5-ht-deficient-mice
#18
Ning-Ning Song, Qiong Zhang, Ying Huang, Ling Chen, Yu-Qiang Ding, Lei Zhang
Serotonin (5-HT) plays an important role in regulating adult hippocampal neurogenesis. Chronic administration of selective 5-HT reuptake inhibitors (SSRIs), which up-regulates extracellular 5-HT concentration, accelerates the maturation of adult-born hippocampal neurons. It is unknown, however, about effects of central 5-HT-deficiency on the dendritic morphogenesis of these newborn neurons. Here, we address this question using two central 5-HT-deficient mouse models, Tph2 conditional knockout mice (CKO) losing central 5-HT from embryonic stage, and Pet1-Cre;Rosa26-DTR (diphtheria toxin receptor) mice lacking central 5-HT neurons exclusively in adulthood...
December 15, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/28011915/genome-wide-association-mapping-of-the-antibody-response-to-diphtheria-tetanus-acellular-pertussis-vaccine-in-mice
#19
Yung-Yi C Mosley, Josiah E Radder, Annerose Berndt, Harm HogenEsch
The objective of the current study was to investigate the genetics of antibody responses to an acellular pertussis vaccine (DTaP) by a genome-wide association study in mice. Female mice of 28 inbred strains received DTaP at 6, 8 and 12 weeks of age. The antibody titer and avidity of IgG specific for diphtheria toxin, pertussis toxin, filamentous hemagglutinin and pertactin were measured at 14 and 24 weeks of age. The magnitude, longevity and avidity of IgG differed significantly among mouse strains. There was significant correlation between antigen-specific IgGs for longevity, but not for magnitude and avidity...
December 23, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27999136/human-muse-cells-reconstruct-neuronal-circuitry-in-subacute-lacunar-stroke-model
#20
Hiroki Uchida, Kuniyasu Niizuma, Yoshihiro Kushida, Shohei Wakao, Teiji Tominaga, Cesario V Borlongan, Mari Dezawa
BACKGROUND AND PURPOSE: Multilineage-differentiating stress-enduring (muse) cells are endogenous nontumorigenic stem cells with pluripotency harvestable as pluripotent marker SSEA-3(+) cells from the bone marrow from cultured bone marrow-mesenchymal stem cells. After transplantation into neurological disease models, muse cells exert repair effects, but the exact mechanism remains inconclusive. METHODS: We conducted mechanism-based experiments by transplanting serum/xeno-free cultured-human bone marrow-muse cells into the perilesion brain at 2 weeks after lacunar infarction in immunodeficient mice...
December 20, 2016: Stroke; a Journal of Cerebral Circulation
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