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Kathrin Schlüter, Josephina Maier, Stefan Patra, Stefan M Gold, Christoph Heesen, Karl-Heinz Schulz
BACKGROUND: The peak blood lactate response to an exhaustive exercise test in a number of chronic conditions has been shown to differ from that seen in healthy, untrained individuals. However, this has not been investigated for patients with multiple sclerosis (MS). OBJECTIVE: The main objective was to determine and compare the peak blood lactate response to exercise and the maximal workload between two groups of MS patients with different illness severity. METHODS: Twenty-five patients with a relapsing-remitting disease course (Group RR) and 41 patients with a secondary- or primary chronic progressive disease course (group CP) performed an exhaustive incremental bicycle ergometry...
October 11, 2017: NeuroRehabilitation
Xingguang Li, Zhixun Wang, Xu Ma, Pei-Nian Liu, Liming Zhang
By using designed biphenyl-2-ylphosphines functionalized with a remote basic groups as ligands, N-alkynyl-o-nosylamides are directly converted to (1E,3E)-1-amido-1,3-dienes with excellent diastereoselectivities under gold catalysis. With allenamides as substrates, the gold-catalyzed isomerizations are high yielding and applicable to a broad substrate scope including various nitrogen protecting groups and exhibit unprecedented (3E)-selectivities for the distal C-C double bond and good regioselectivities. Combining this gold catalysis with one-pot Diels-Alder reactions leads to rapid assembly of valuable bicyclic compounds...
October 16, 2017: Organic Letters
Neil Maizlish, Nicholas J Linesch, James Woodcock
The purpose of this research was to quantify health co-benefits and carbon reductions of preferred scenarios of California regional transportation plans and alternatives with ambitious levels of active transport. The alternatives were designed to examine the efficacy of independent contributions of walking, bicycling, and transit at levels consistent with the U.S. Surgeon General recommendation for physical activity. Using data from travel and health surveys, vital statistics, collision databases, and outputs from regional and statewide travel models, the Integrated Transport and Health Impacts Model estimated the change in the population disease burden, as measured by deaths and disability adjusted life years (DALYs), due to a shift from a 2010 baseline travel pattern to an alternative...
September 2017: Journal of Transport & Health
Zhihui Lu, Jean Woo, Timothy Kwok
Background: It is unclear whether physical activity (PA) could predict all-cause mortality independently of cardiorespiratory fitness, and there are relatively few studies evaluating the combined effect of PA and cardiorespiratory fitness on mortality. Methods: We invited 1,242 Chinese older adults aged 69 to 94 years from the MrOs and MsOs cohort (Hong Kong) study for a 7-year follow-up. PA was measured by the Physical Activity Scale of the Elderly (PASE). Cardiorespiratory fitness, expressed as maximal oxygen uptake (VO2max), was assessed by performing symptom-limited maximal exercise testing on an electrically braked bicycle ergometer and 6-meter walk test...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Ke Chen, Shuai Liu, Dan Wang, Wen-Juan Hao, Peng Zhou, Shu-Jiang Tu, Bo Jiang
The combination of AgTFA and Sc(OTf)3 enables the bimetallic synergistic catalysis of β-alkynyl ketones and para-quinone methides (p-QMs), allowing direct synthesis of 17 examples of benzo[c]xanthenes with generally good yields through a benzannulation /1,6-addition/cyclization sequence. Exchanging p-QMs for quinone imine ketal (QIK) resulted in 10 examples of tetracyclic naphtho[1,2-b]benzofurans via a similar benzannulation /1,4-addition/cyclization cascade. During these reaction processes, AgTFA and Sc(OTf)3 could be perfectly compatible, together with the realization of C(sp3)-H functionalization adjacent to carbonyl group on the β-alkynyl ketone unit...
October 13, 2017: Journal of Organic Chemistry
Simen G Antonsen, Harrison Gallantree-Smith, Carl Henrik Görbitz, Trond Vidar Hansen, Yngve H Stenstrøm, Jens M J Nolsøe
A stereodivergent total synthesis has been executed based on the plausibly misassigned structure of the unusual marine hydrindane mucosin (1). The topological connectivity of the four contiguous all-carbon stereocenters has been examined by selective permutation on the highlighted core. Thus, capitalizing on an unprecedented stereofacial preference of the cis-fused bicycle[4.3.0]non-3-ene system when a Michael acceptor motif is incorporated, copper-mediated conjugate addition furnished a single diastereomer...
October 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
M Herteleer, T Winckelmans, H Hoekstra, S Nijs
PURPOSE: In the last 10 years, there has been an increasing tendency toward operative fixation of clavicle fractures. In this retrospective analysis, we will demographically assess all patients who sustained a clavicle fracture and were treated in our university hospital between 2004 and 2014. METHODS: We retrospectively updated our database and analyzed all adult patients who were diagnosed with a clavicle fracture in our hospital. The following parameters were included in the database: age, gender, Robinson classification, date of trauma, injury mechanism, time until surgery, and reason for delayed surgery...
October 13, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Heeoon Han, Amos B Smith
An effective [3+2] annulation tactic for the construction of diverse bicyclic compounds possessing highly functionalized cyclopentane rings has been developed employing soft ketone enolates as the initial nucleophile for anion relay chemistry (ARC). The protocol entails a highly diastereoselective aldol/Brook rearrangement/cyclization cascade.
October 10, 2017: Angewandte Chemie
David M Kaye, Frank E Silvestry, Finn Gustafsson, John G Cleland, Dirk J van Veldhuisen, Piotr Ponikowski, Jan Komtebedde, Shane Nanayakkara, Dan Burkhoff, Sanjiv J Shah
AIMS: Heart failure with preserved (HFpEF) and mid-range ejection fraction (HFmrEF) are becoming the most prevalent forms of heart failure. Patients with HFpEF/HFmrEF in atrial fibrillation (AF) have poorer survival and quality of life, but the mechanism underpinning this is unknown. We sought to investigate the influence of AF on the haemodynamic profile of HFpEF/HFmrEF patients at rest and during exercise. METHODS AND RESULTS: We invasively measured central haemodynamics at rest and during symptom-limited supine bicycle exercise in HFpEF/HFmrEF patients, 35 in sinus rhythm and 20 in AF with matched left ventricular ejection fraction...
October 11, 2017: European Journal of Heart Failure
Dominique Hansen, An Soors, Valerie Deluyker, Ines Frederix, Paul Dendale
BACKGROUND: Electrical assisted bicycles (EAB's) could be used to overcome barriers and difficulties to outdoor cycling and thus assist in achieving a sufficient physical activity level in coronary artery disease (CAD) patients, but it is unknown whether sufficient exercise intensities and volumes could be elicited during cycling on EAB's. In this study we examined, for the first time, the acute physiological impact of electrical support during outdoor cycling in CAD patients (ISRCTN32238279)...
October 10, 2017: Acta Cardiologica
Georg Strasser, Stefan Hiebaum, Manfred Neuberger
Mass concentrations PM10, PM2.5, PM1, particle number concentrations of ultrafine particles and lung deposited surface area were measured during commutes with a subway, tram, bus, car and bicycle in Vienna for the first time. Obtained data were examined for significant differences in personal exposure when using various transport modalities along similar routes. Mean PM2.5 and PM1 mass concentrations were significantly higher in the subway when compared to buses. Mean PM10, PM2.5 and PM1 mass concentrations were significantly higher in the subway when compared to cars using low ventilation settings...
October 9, 2017: Wiener Klinische Wochenschrift
Andreas Holtermann, Finn Gyntelberg, Adrian Bauman, Magnus Thorsten Jensen
AIMS: Increases in prevalence have led to a diabetes pandemic. Obesity and low cardiorespiratory fitness (CRF) are considered to be central mechanisms. We investigated if the effect of CRF on diabetes risk was equivalent across levels of fatness among healthy men. METHODS: In total 4,988 middle-aged Caucasian employed men free of cardiovascular disease, diabetes and cancer were included from the Copenhagen Male Study starting in 1970-71. CRF was assessed using a sub-maximal bicycle ergometer test and body mass index (BMI) was measured by height and weight...
October 6, 2017: Diabetes Research and Clinical Practice
Po-Ting Tung, Chang-Zhi Zhong, Tzu-Chiang Chien, Ming-Chang P Yeh
A simple synthetic method to construct the spirolactam framework from TfOH-catalyzed spirolactamization of cyclohex-2-enols bearing a tethered (arylethynyl(tosyl)amino)methyl moiety is described. The reaction proceeded through a keteniminium-allylic carbocation intermediate. Hydration of the keteniminium ion, followed by attack of the resulting enolate onto the tethered allylic carbocation, provided the spirolactam ring skeleton. This strategy could also be employed in the synthesis of fused bicyclic lactams from BF3·OEt2-assisted cyclolactamization of TBS-protected 2-(ethynyl(tosyl)amino)methylcyclohex-2-enols...
October 16, 2017: Journal of Organic Chemistry
Lewis C Wilkins, Rebecca L Melen, James A Platts, Paul D Newman
Attachment of racemic 1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphatricyclo[,7)]decane (α,β-CgP) to (1R,5S)-1,8,8-trimethyl-2,4-diazabicyclo[3.2.1]oct-2-ene gave a diastereomeric mixture of a novel amidine-phosphine ligand, α,β-CgPAm. The phosphination was completely selective for the 4-position of the bicyclic amidine and there was no subsequent 1,2-migration of the α,β-CgP group. Methylation of the non-phosphinated nitrogen gave the amidinium salt [α,β-CgPAmMe]BF4 as a diastereomeric mixture...
October 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Xingwang Zhang, Zhong Li, Lei Du, George E Chlipala, Patricia C Lopez, Wei Zhang, David H Sherman, Shengying Li
Tirandamycin K (7), the first linear 7,13;9,13-diseco-tirandamycin derivative, was isolated from the tamI (encoding the TamI P450 monooxygenase) disruption mutant strain (ΔtamI) of marine Streptomyces sp. 307-9. Its chemical structure with relative and absolute configurations was elucidated by a combination of extensive spectroscopic analyses and biosynthetic inferences. Structural elucidation of this unusual compound provides new insights into tirandamycin biosynthesis. Moreover, examination of the biological activity of 7 confirms the essential function of the bicyclic ketal ring for antibiotic activities of tirandamycins...
December 28, 2016: Tetrahedron Letters
Gustaaf J C van Baar, Muhammad Ruslin, Maureen van Eijnatten, George K Sándor, Tymour Forouzanfar, Jan Wolff
OBJECTIVES: In the Netherlands, cyclists continue to outnumber other road users in injuries and deaths. The wearing of bicycle helmets is not mandatory in the Netherlands even though research has shown that wearing bicycle helmets can reduce head and brain injuries by up to 88%. Therefore, the aim of this study was to assess the feasibility of using 3D technology to evaluate bicycle-related head injuries and helmet protection. METHODS: Three patients who had been involved in a bicycle accident while wearing a helmet were subjected to multi-detector row computed tomography (MDCT) imaging after trauma...
September 29, 2017: Injury
Adam Eriksson, Charlotte Kürten, Per-Olof Syrén
Terpenes represent one of the most diversified classes of natural products with potent biological activities. The key to the myriad of polycyclic terpene skeletons with crucial functions in organisms from all kingdoms of life are terpene cyclase enzymes. These biocatalysts enable stereospecific cyclization of relatively simple, linear pre-folded polyisoprenes by highly complex, partially concerted, electrophilic cyclization cascades that remain incompletely understood. Herein, we shed additional mechanistic light on terpene biosynthesis by kinetic studies in mixed H2O/D2O buffers of a class II bacterial ent-copalyl diphosphate synthase...
October 5, 2017: Chembiochem: a European Journal of Chemical Biology
Neal J Russell, Paul Bassett, John Chang
Objective: Difficult intravenous (IV) access can compromise patient care in neonatal practice, and transillumination is often used to improve the visibility of veins. Current devices are expensive, prone to bacterial contamination and unaffordable in low-resource settings. We conducted a study comparing the quality of transillumination provided by "cold lights" that are currently in use with low-cost (<£1) red silicone LED bicycle lights. Methods: Photographs of the hands and feet of neonates were taken with parental consent: first without transillumination (control group), second by transillumination with a cold light, and third with a bicycle light...
August 10, 2017: Journal of Tropical Pediatrics
Masahiro Anada, Taiki Hanari, Kosuke Kakita, Yasunobu Kurosaki, Kazuki Katsuse, Yuta Sunadoi, Yu Jinushi, Koji Takeda, Shigeki Matsunaga, Shunichi Hashimoto
The first total synthesis of brasilicardins A and C, novel diterpenoid-saccharide-amino acid hybrid metabolites with unique immunosuppressive activity, is described. The key step is a Diels-Alder/reductive angular methylation sequence capitalizing on a trans-fused bicyclic α-cyano-α,β-enone as its precursor to construct the 8,10-dimethyl-trans/syn/trans-perhydrophenanthrene skeleton. Other notable features include an anti-selective aldol reaction, a stereocontrolled glycosylation of a C2 alcohol, and a one-pot, two-step global deprotection sequence that did not damage these sensitive molecules...
October 4, 2017: Organic Letters
Kevin M Harris, Lawrence L Creswell, Tammy S Haas, Taylor Thomas, Monica Tung, Erin Isaacson, Ross F Garberich, Barry J Maron
Background: Reports of race-related triathlon fatalities have raised questions regarding athlete safety. Objective: To describe death and cardiac arrest among triathlon participants. Design: Case series. Setting: United States. Participants: Participants in U.S. triathlon races from 1985 to 2016. Measurements: Data on deaths and cardiac arrests were assembled from such sources as the U...
September 19, 2017: Annals of Internal Medicine
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