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https://www.readbyqxmd.com/read/28230705/determinant-variables-enteric-pathogen-burden-gut-function-and-immune-related-inflammatory-biomarkers-associated-with-childhood-malnutrition-a-prospective-case-control-study-in-northeastern-brazil
#1
Aldo Am Lima, Álvaro M Leite, Alessandra Di Moura, Noélia L Lima, Alberto M Soares, Cláudia B Abreu, José Quirino Filho, Rosa Ms Mota, Ila Fn Lima, Alexandre Havt, Pedro Hqs Medeiros, Mara Mg Prata, Marjorie M Guedes, Paloma A Cavalcante, Herlice N Veras, Ana Ks Santos, Sean R Moore, Relana C Pinkerton, Eric R Houpt, Richard L Guerrant
Malnutrition results in serious consequences for growth and cognitive development in children. We studied select child and maternal biological factors, socio-economic factors, enteric pathogenic burden, and gut function biomarkers in 402 children 6-24 months of age in North-eastern Brazil. In this prospective case-control study, not being fed colostrum (odds ratio [OR] = 3.29, 95% confidence interval [CI] 1.73-6.26), maternal age ≥18 years (OR = 1.88, 95% CI 1.10-3.22), and no electrical fan (OR = 2.46, 95% CI 1...
February 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28230359/efficient-liver-targeting-by-polyvalent-display-of-a-compact-ligand-for-the-asialoglycoprotein-receptor
#2
Carlos A Sanhueza, Michael M Baksh, Benjamin Thuma, Marc D Roy, Sanjay Dutta, Cathy Préville, Boris A Chrunyk, Kevin Beaumont, Robert Dullea, Mark Ammirati, Shenping Liu, David Gebhard, James E Finley, Christopher T Salatto, Amanda King-Ahmad, Ingrid Stock, Karen Atkinson, Benjamin Reidich, Wen Lin, Rajesh Kumar, Meihua Tu, Elnaz Menhaji-Klotz, David A Price, Spiros Liras, M G Finn, Vincent Mascitti
A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency, and the molecular details of binding were revealed by the first X-ray crystal structures of ligand-bound ASGPR. This analogue was used to make potent di- and trivalent binders of ASGPR. Extensive characterization of the function of these compounds showed rapid ASGPR-dependent cellular uptake in vitro and high levels of liver/plasma selectivity in vivo...
February 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28226906/a-new-crank-arm-based-load-cell-with-built-in-conditioning-circuit-and-strain-gages-to-measure-the-components-of-the-force-applied-by-a-cyclist
#3
Andre V Pigatto, Karina O A Moura, Gabriela W Favieiro, Alexandre Balbinot, Andre V Pigatto, Karina O A Moura, Gabriela W Favieiro, Alexandre Balbinot, Karina O A Moura, Gabriela W Favieiro, Alexandre Balbinot, Andre V Pigatto
This report describes the development of a force platform based on instrumented load cells with built-in conditioning circuit and strain gages to measure and acquire the components of the force that is applied to the bike crank arm during pedaling in real conditions, and save them on a SD Card. To accomplish that, a complete new crank arm 3D solid model was developed in the SolidWorks, with dimensions equivalent to a commercial crank set and compatible with a conventional road bike, but with a compartment to support all the electronics necessary to measure 3 components of the force applied to the pedal during pedaling...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225621/silver-catalyzed-1-3-acyloxy-migration-diels-alder-reaction-of-1-9-dien-4-yne-esters-to-partially-hydrogenated-isoquinolines
#4
Yichao Zhao, Jianwen Jin, Joshua William Boyle, Bo Ra Lee, David P Day, Dewi Susanti, Guy J Clarkson, Philip Wai Hong Chan
A synthetic method to prepare partially hydrogenated isoquinolines efficiently from silver-mediated [3,3]-sigmatropic rearrangement/Diels-Alder reaction of 1,9-dien-4-yne esters is described. The reactions were shown to be robust with a wide variety of substitution patterns tolerated to provide the corresponding nitrogen-containing heterocyclic products in good to excellent yields. This includes examples containing a bridgehead sp3 quaternary carbon center as well as the cycloisomerization of one substrate to give the corresponding bicyclic adduct in excellent yield at the gram-scale...
February 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28224232/effects-of-traumeel-tr14-on-recovery-and-inflammatory-immune-response-after-repeated-bouts-of-exercise-a-double-blind-rct
#5
Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren
PURPOSE: The purpose of this double-blind, randomized, placebo-controlled clinical trial was to investigate the effects of the natural combination medicine Traumeel (Tr14) consisting of 14 diluted biological and mineral components on the inflammatory immune response and recovery up to 72 h after repetitive bouts of bicycle tests. METHODS: Antigen-stimulated IL-1ra and IL-6 were defined as primary outcome measures. Moreover, various immunological and serum muscle damage markers were investigated...
February 21, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28223189/the-unrealised-potential-of-bike-share-schemes-to-influence-population-physical-activity-levels-a-narrative-review
#6
Adrian Bauman, Melanie Crane, Bradley Alan Drayton, Sylvia Titze
The recent proliferation of bike share schemes (BSS, also known as public bicycle use programs) in many cities has focused attention on their potential for reducing motorised traffic congestion, improving air quality and reducing car use. Since 2005, hundreds of bike share schemes have been implemented in many cities, with bike share usage patterns monitored in many of them. This paper assesses the development of BSS and provides a rationale for their potential health benefits. The key research question, as yet unanswered, is whether BSS themselves can contribute to improving population health, particularly through increasing population cycling, which would increase population levels of health-enhancing physical activity...
February 18, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28218498/optimization-of-bicyclic-lactam-derivatives-as-nmda-receptor-antagonists
#7
Margarida Espadinha, Jorge Dourado, Rocio Lajarin-Cuesta, Clara Herrera-Arozamena, Lidia Gonçalves, Maria Isabel Rodríguez-Franco, Cristobal de Los Rios, Maria M M Santos
N-Methyl-D-aspartate (NMDA) receptors are fundamental for the normal function of the central nerve system, and play an important role in memory and learning. An overactivation of these receptors will lead to neuronal loss associated with major neurological disorders, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and epilepsy. Herein, twenty two novel enantiopure bicyclic lactams were designed, synthesized, and evaluated as NMDA receptor antagonists. Most of the new compounds displayed NMDA receptor antagonism and, the most promising compound showed IC50 value in the same order of magnitude of memantine, a NMDA receptor antagonist used in the clinic for the treatment of Alzheimer's disease...
February 20, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28217842/a-short-total-synthesis-of-%C3%A2-lycorane-by-a-sequential-intramolecular-acylal-cyclisation-iac-and-intramolecular-heck-addition-reaction
#8
Alessandra Monaco, Blanka R Szulc, Zenobia X Rao, Marta Barniol-Xicota, Moussa Sehailia, Bruno Borges, Stephen Hilton
An intramolecular acylal cyclisation (IAC) approach to the synthesis of a range of bicyclic heterocycles is reported. As an example of the utility of the IAC reaction, the methodology was applied in a protecting-group free five-step total synthesis of (±)-lycorane, incorporating a novel intramolecular Heck addition reaction to generate the pentacyclic core structure of the natural product in good yield.
February 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28215415/diagnostic-and-prognostic-value-of-lead-avr-during-exercise-testing-in-patients-suspected-of-having-myocardial-ischemia
#9
Max Wagener, Roger Abächerli, Ursina Honegger, Nicolas Schaerli, Gil Prêtre, Raphael Twerenbold, Christian Puelacher, Germaine Sunier, Philipp Reddiess, Maria Rubini Gimenez, Karin Wildi, Jasper Boeddinghaus, Thomas Nestelberger, Patrick Badertscher, Zaid Sabti, Ramun Schmid, Remo Leber, Dayana Flores Widmer, Samyut Shrestha, Ivo Strebel, Damian Wild, Stefan Osswald, Michael Zellweger, Christian Mueller, Tobias Reichlin
We aimed to assess the diagnostic and prognostic value of ST-segment deviation in aVR, a lead often ignored in clinical practice, during exercise testing and to compare it to the most widely used criterion of ST-segment depression in V5. We enrolled 1,596 patients with suspected myocardial ischemia referred for nuclear perfusion imaging undergoing bicycle stress testing. ST-segment amplitudes in leads aVR and V5 were automatically measured. The presence of inducible myocardial ischemia was the diagnostic end point and adjudicated based on nuclear perfusion imaging and coronary angiography...
January 5, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28209593/comparing-icd-10-external-cause-codes-for-pedal-cyclists-with-self-reported-crash-details
#10
Ben Beck, Christina L Ekegren, Peter Cameron, Mark Stevenson, Rodney Judson, Andrew Bucknill, Elton Edwards, Belinda Gabbe
Accurate coding of injury event information is critical in developing targeted injury prevention strategies. However, little is known about the validity of the most universally used coding system, the International Classification of Diseases (ICD-10), in characterising crash counterparts in pedal cycling events. This study aimed to determine the agreement between hospital-coded ICD-10-AM (Australian modification) external cause codes with self-reported crash characteristics in a sample of pedal cyclists admitted to hospital following bicycle crashes...
February 16, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28202071/clavicle-fractures-epidemiology-classification-and-treatment-of-2-422-fractures-in-the-swedish-fracture-register-an-observational-study
#11
Caroline Kihlström, Michael Möller, Katarina Lönn, Olof Wolf
BACKGROUND: Large multi-centre studies of clavicle fractures have so far been missing. The aim of this observational study was to describe the epidemiology, classification and treatment of clavicle fractures in the The Swedish Fracture Register (SFR) that collects national prospective data from large fracture populations. METHODS: Data were retrieved from the SFR on all clavicle fractures sustained by patients ≥ 15 years of age in 2013-2014 (n = 2 422) with regards to date of injury, cause of injury, fracture classification and treatment...
February 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28198182/synthesis-of-enantiopure-dabo-derivatives-c1-symmetric-chiral-1-2-diamines-with-a-rigid-bicyclic-backbone
#12
Pierre Milbeo, Laure Moulat, Claude Didierjean, Emmanuel Aubert, Jean Martinez, Monique Calmès
The synthesis of enantiopure 1,2-diaminobicyclo[2.2.2]octane (DABO) 1 and its two selectively N-Boc mono-protected derivatives 15 and 16 is described. Starting from bicyclic β-amino acid 3 or 5, strategies involving Curtius and Hofmann rearrangements were explored, demonstrating the unprecedented influence of the bicyclic backbone unsaturation for the preparation of the corresponding diamines that could be only obtained in good yield using the Hofmann rearrangement of unsaturated compound 3. The divergent outcome observed during the Hofmann rearrangement of 3 and 5 was investigated by DFT calculations...
February 15, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28194116/dynamic-and-static-exercises-differentially-affect-plasma-cytokine-content-in-elite-endurance-and-strength-trained-athletes-and-untrained-volunteers
#13
Leonid V Kapilevich, Anna N Zakharova, Anastasia V Kabachkova, Tatyana A Kironenko, Sergei N Orlov
Extensive exercise increases the plasma content of IL-6, IL-8, IL-15, leukemia inhibitory factor (LIF), and several other cytokines via their augmented transcription in skeletal muscle cells. However, the relative impact of aerobic and resistant training interventions on cytokine production remains poorly defined. In this study, we compared effects of dynamic and static load on cytokine plasma content in elite strength- and endurance-trained athletes vs. healthy untrained volunteers. The plasma cytokine content was measured before, immediately after, and 30 min post-exercise using enzyme-linked immunosorbent assay...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28193281/municipal-investment-in-off-road-trails-and-changes-in-bicycle-commuting-in-minneapolis-minnesota-over-10%C3%A2-years-a-longitudinal-repeated-cross-sectional-study
#14
Jana A Hirsch, Katie A Meyer, Marc Peterson, Le Zhang, Daniel A Rodriguez, Penny Gordon-Larsen
BACKGROUND: We studied the effect of key development and expansion of an off-road multipurpose trail system in Minneapolis, Minnesota between 2000 and 2007 to understand whether infrastructure investments are associated with increases in commuting by bicycle. METHODS: We used repeated measures regression on tract-level (N = 116 tracts) data to examine changes in bicycle commuting between 2000 and 2008-2012. We investigated: 1) trail proximity measured as distance from the trail system and 2) trail potential use measured as the proportion of commuting trips to destinations that might traverse the trail system...
February 13, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28189058/using-data-mining-techniques-to-predict-the-severity-of-bicycle-crashes
#15
Gabriele Prati, Luca Pietrantoni, Federico Fraboni
To investigate the factors predicting severity of bicycle crashes in Italy, we used an observational study of official statistics. We applied two of the most widely used data mining techniques, CHAID decision tree technique and Bayesian network analysis. We used data provided by the Italian National Institute of Statistics on road crashes that occurred on the Italian road network during the period ranging from 2011 to 2013. In the present study, the dataset contains information about road crashes occurred on the Italian road network during the period ranging from 2011 to 2013...
February 8, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28188199/back-to-the-future-revisiting-the-physiological-cost-of-negative-work-as-a-team-based-activity-for-exercise-physiology-students
#16
Matthew A Kilgas, Steven J Elmer
We implemented a team-based activity in our exercise physiology teaching laboratory that was inspired from Abbott et al.'s classic 1952 Journal of Physiology paper titled "The physiological cost of negative work." Abbott et al. connected two bicycles via one chain. One person cycled forward (muscle shortening contractions, positive work) while the other resisted the reverse moving pedals (muscle lengthening contractions, negative work), and the cost of work was compared. This study was the first to link human whole body energetics with isolated muscle force-velocity characteristics...
March 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28186780/intramolecular-nitrone-cycloaddition-of-%C3%AE-trifluoromethyl-styrenes-role-of-the-cf3-group-in-the-regioselectivity
#17
Fernando Rabasa-Alcañiz, Amparo Asensio, María Sánchez-Roselló, Marcos Escolano, Carlos Del Pozo, Santos Fustero
The intramolecular 1,3-dipolar cycloaddition of ortho-substituted 1,1,1-trifluoromethylstyrene-derived nitrones is described. Tricyclic fused isoxazolidines were obtained as major or exclusive products, in contrast to the case for nonfluorinated substrates, which rendered the bridged derivatives. This change in the regioselectivity was attributed to the electronic and, particularly, steric requirements of the trifluoromethyl group in comparison to the methyl group. It is worth mentioning that trifluoromethylstyrenes have been employed for the first time as dipolarophiles in a 1,3-dipolar intramolecular cycloaddition reaction, leading to the corresponding isoxazolidines bearing a quaternary trifluoromethyl moiety...
February 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28182857/fluoride-mediated-desulfonylative-intramolecular-cyclization-to-fused-and-bridged-bicyclic-compounds-a-complex-mechanism
#18
Michelle Bezanson, Anna Tomberg, Nicolas Moitessier
We previously reported the synthesis of polysubstituted chiral oxazepanes in three steps from commercially available starting materials. The unexpected reaction of one of these 1,4-oxazepanes in the presence of TBAF provided a 4-oxa-1-azabicyclo[4.1.0]heptane core. This unusual process significantly increased the complexity of the molecular scaffold by introducing a bicyclic core. Surprisingly, the generated bicyclic structure featuring three stereocenters was a mixture of enantiomers with no other diastereomers observed...
February 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28179011/cardiorespiratory-and-metabolic-responses-to-body-mass-based-squat-exercise-in-young-men
#19
Miki Haramura, Yohei Takai, Takaya Yoshimoto, Masayoshi Yamamoto, Hiroaki Kanehisa
BACKGROUND: The purpose of this study was to quantify cardiorespiratory and metabolic responses to body mass-based squat exercise, with specific emphasis on the relationships with the exercise duration. METHODS: Fifteen healthy young men performed body mass-based squat exercise as well as an incremental loaded bicycle test, which determine maximal oxygen uptake and maximal heart rate, with an interval of 2 days between the tests. During both tasks, oxygen uptake, blood lactate concentration (BLa), and heart rate (HR) were determined...
February 8, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28169387/mimics-of-pramanicin-derived-from-pyroglutamic-acid-and-their-antibacterial-activity
#20
Song Wei Benjamin Tan, Christina L L Chai, Mark G Moloney
Mono and dihydroxypyrrolidinones are readily available by direct oxygenation of a pyroglutamate-derived bicyclic lactam with high diastereoselectivity, and these may be manipulated further in protected or unprotected form by Grignard addition to a pendant Weinreb amide to give acylhydroxypyrrolidinones, which are analogues of the natural product, pramanicin. Preliminary bioassay against S. aureus and E. coli indicated that some compounds exhibit selective Gram-negative antibacterial activity, and may offer promise for the development of novel systems suitable for antibacterial drug development...
February 7, 2017: Organic & Biomolecular Chemistry
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