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https://www.readbyqxmd.com/read/28606563/participants-with-pharmacologically-impaired-taste-function-seek-out-more-intense-higher-calorie-stimuli
#1
Corinna A Noel, Meaghan Sugrue, Robin Dando
OBJECTIVE: Research suggests a weaker sense of taste in people with obesity, with the assumption that a debilitated taste response increases the desire for more intensely tasting stimuli to compensate for decreased taste input. However, empirical testing of this supposition remains largely absent. METHOD: In a randomized, repeated measures design, 51 healthy subjects were treated with varying concentrations of a tea containing Gymnema sylvestre (GS), to temporarily and selectively diminish sweet taste perception, or a control tea...
June 9, 2017: Appetite
https://www.readbyqxmd.com/read/28585209/influence-of-antioxidants-on-leptin-metabolism-and-its-role-in-the-pathogenesis-of-obesity
#2
Harald Mangge, Christian Ciardi, Kathrin Becker, Barbara Strasser, Dietmar Fuchs, Johanna M Gostner
Obesity is associated with low-grade inflammation. Leptin, a hormone made by fat cells regulates appetite and hunger and thus food intake behavior. Interestingly, , food preservatives like sodium sulfite and sodium benzoate and also natural colorant and spice compounds such as curcumin were found to decrease the release of leptin in murine 3T3-L1 adipocytes, after co-incubation with LPS, which was added to mimic the pro-inflammatory status in obesity. Several of these compounds are well known food antioxidants...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28548389/night-shift-work-is-associated-with-poorer-glycaemic-control-in-patients-with-type-2-diabetes
#3
Areesa Manodpitipong, Sunee Saetung, Hataikarn Nimitphong, Nantaporn Siwasaranond, Thanawat Wongphan, Chotima Sornsiriwong, Pranee Luckanajantachote, Prasitchai Mangjit, Prasit Keesukphan, Stephanie J Crowley, Megan M Hood, Sirimon Reutrakul
The circadian system plays a role in regulating metabolism. Night-shift work, a form of circadian misalignment, is associated with increased type 2 diabetes risk. This study aimed to determine if night-shift workers with type 2 diabetes experience poorer glycaemic control than non-shift workers. Patients with type 2 diabetes (104 unemployed, 85 day workers and 60 night-shift workers) participated. Sleep duration, sleep quality, morningness-eveningness preference, depressive symptoms and dietary intake were assessed using standardized questionnaires...
May 26, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28545455/the-effect-of-weight-loss-on-hdl-subfractions-and-lcat-activity-in-two-genotypes-of-apoa-ii-265t-c-polymorphism
#4
Masoumeh Moradi, Maryam Mahmoudi, Ahmad Saedisomeolia, Roxana Zahirihashemi, Fariba Koohdani
BACKGROUND: People may have different responses to the same environmental changes. It has been reported that genome variations may be responsible for these differences. Also, HDL subfractions may be influenced by different genetic variations. The aim of the present study was to determine gene-diet interactions and to evaluate the influence of weight loss on HDL subfractions between two genotypes of -265 T>C APOA-II polymorphism. METHODS: In the present study, 56 overweight and obese patients with type 2 diabetes mellitus were selected from 697 genotype-specified subjects...
May 25, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28474121/optimal-nutrition-and-the-ever-changing-dietary-landscape-a-conference-report
#5
A Shao, A Drewnowski, D C Willcox, L Krämer, C Lausted, M Eggersdorfer, J Mathers, J D Bell, R K Randolph, R Witkamp, J C Griffiths
The field of nutrition has evolved rapidly over the past century. Nutrition scientists and policy makers in the developed world have shifted the focus of their efforts from dealing with diseases of overt nutrient deficiency to a new paradigm aimed at coping with conditions of excess-calories, sedentary lifestyles and stress. Advances in nutrition science, technology and manufacturing have largely eradicated nutrient deficiency diseases, while simultaneously facing the growing challenges of obesity, non-communicable diseases and aging...
May 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28460894/intravenous-administration-of-oxytocin-in-rats-acutely-decreases-deprivation-induced-chow-intake-but-it-fails-to-affect-consumption-of-palatable-solutions
#6
Anica Klockars, Chloe Brunton, Lu Li, Allen S Levine, Pawel K Olszewski
Despite its limited ability to cross the blood-brain barrier, peripherally administered oxytocin (OT) acutely decreases food intake, most likely via the brainstem and hypothalamic mechanisms. Studies performed to date have focused mainly on the effects of subcutaneous or intraperitoneal OT on the consumption of only solid calorie-dense diets (either standard or high-fat), whereas it is unknown whether, similarly to central OT, peripherally administered peptide reduces intake of calorie-dilute and non-caloric palatable solutions...
April 28, 2017: Peptides
https://www.readbyqxmd.com/read/28412652/during-yeast-chronological-aging-resveratrol-supplementation-results-in-a-short-lived-phenotype-sir2-dependent
#7
Ivan Orlandi, Giulia Stamerra, Maurizio Strippoli, Marina Vai
Resveratrol (RSV) is a naturally occurring polyphenolic compound endowed with interesting biological properties/functions amongst which are its activity as an antioxidant and as Sirtuin activating compound towards SIRT1 in mammals. Sirtuins comprise a family of NAD(+)-dependent protein deacetylases that are involved in many physiological and pathological processes including aging and age-related diseases. These enzymes are conserved across species and SIRT1 is the closest mammalian orthologue of Sir2 of Saccharomyces cerevisiae...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28410489/the-contribution-of-urbanization-to-non-communicable-diseases-evidence-from-173-countries-from-1980-to-2008
#8
Yevgeniy Goryakin, Lorenzo Rocco, Marc Suhrcke
It is widely believed that the expanding burden of non-communicable diseases (NCDs) is in no small part the result of major macro-level determinants. We use a large amount of new data, to explore in particular the role played by urbanization - the process of the population shifting from rural to urban areas within countries - in affecting four important drivers of NCDs world-wide: diabetes prevalence, as well as average body mass index (BMI), total cholesterol level and systolic blood pressure. Urbanization is seen by many as a double-edged sword: while its beneficial economic effects are widely acknowledged, it is commonly alleged to produce adverse side effects for NCD-related health outcomes...
March 27, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28387720/gene-diet-interaction-and-precision-nutrition-in-obesity
#9
REVIEW
Yoriko Heianza, Lu Qi
The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epidemic. Growing studies have found that changes in adiposity and metabolic response to low-calorie weight loss diets might be modified by genetic variants related to obesity, metabolic status and preference to nutrients...
April 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28293018/exploring-the-relationship-between-%C3%AE-actinin-3-deficiency-and-obesity-in-mice-and-humans
#10
P J Houweling, Y D Berman, N Turner, K G R Quinlan, J T Seto, N Yang, M Lek, D G Macarthur, G Cooney, K N North
Obesity is a worldwide health crisis and the identification of genetic modifiers of weight gain is crucial in understanding this complex disorder. A common null polymorphism in the fast fiber-specific gene ACTN3 (R577X) is known to influence skeletal muscle function and metabolism. α-Actinin-3 deficiency occurs in an estimated 1.5 billion people worldwide, and results in reduced muscle strength and a shift towards a more efficient oxidative metabolism. The X-allele has undergone strong positive selection during recent human evolution and in this study we sought to determine whether ACTN3 genotype influences weight gain and obesity in mice and humans...
March 15, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28277962/oxidative-challenges-of-avian-migration-a-comparative-field-study-on-a-partial-migrant
#11
Cas Eikenaar, Emma Källstig, Martin N Andersson, Amparo Herrera-Dueñas, Caroline Isaksson
Most avian migrants alternate flight bouts, characterized by high metabolic rates, with stopovers, periods of fuel replenishment through hyperphagia. High-energy metabolism and excessive calorie intake shift the balance between damaging prooxidants and antioxidants toward the former. Hence, migration likely affects the oxidative balance of birds. Migratory flight indeed appears to cause oxidative damage; however, whether migration affects the oxidative state of birds at stopover is unclear. Therefore, we compared total nonenzymatic antioxidant capacity (AOX) and malondialdehyde concentration (MDA; a measure of lipid peroxidation) in the plasma of migrant and resident common blackbirds...
March 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28264001/a-camera-phone-based-study-reveals-erratic-eating-pattern-and-disrupted-daily-eating-fasting-cycle-among-adults-in-india
#12
Neelu Jain Gupta, Vinod Kumar, Satchidananda Panda
The daily rhythm of feeding-fasting and meal-timing are emerging as important determinants of health. Circadian rhythm research in animal models and retrospective analyses of human nutrition data have shown that reduced length of overnight fasting or increased late night eating increases risk for metabolic diseases including obesity and diabetes. However, the daily rhythm in eating pattern in humans is rarely measured. Traditional methods to collect nutrition information through food diary and food log pay little attention to the timing of eating which may also change from day to day...
2017: PloS One
https://www.readbyqxmd.com/read/28251799/diet-affects-arctic-ground-squirrel-gut-microbial-metatranscriptome-independent-of-community-structure
#13
Jasmine J Hatton, Timothy J Stevenson, C Loren Buck, Khrystyne N Duddleston
We examined the effect of diet on pre-hibernation fattening and the gut microbiota of captive arctic ground squirrels (Urocitellus parryii). We measured body composition across time and gut microbiota density, diversity and function prior to and after five-weeks on control, high-fat, low-fat (18%, 40% and 10% energy from fat, respectively), or restricted calorie (50% of control) diets. Squirrels fattened at the same rate and to the same degree on all diets. Additionally, we found no differences in gut microbiota diversity or short chain fatty acid production across time or with diet...
April 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28251782/one-year-calorie-restriction-impacts-gut-microbial-composition-but-not-its-metabolic-performance-in-obese-adolescents
#14
Alicia Ruiz, Tomás Cerdó, Ruy Jáuregui, Dietmar H Pieper, Ascensión Marcos, Alfonso Clemente, Federico García, Abelardo Margolles, Manuel Ferrer, Cristina Campoy, Antonio Suárez
Recent evidence has disclosed a connection between gut microbial glycosidase activity and adiposity in obese. Here, we measured microbial α-glucosidase and β-galactosidase activities and sorted fluorescently labeled β-galactosidase containing (βGAL) microorganisms in faecal samples of eight lean and thirteen obese adolescents that followed a controlled calorie restriction program during one year. β-galactosidase is a highly distributed functional trait, mainly expressed by members of Blautia, Bacteroides, Alcaligenes, Acinetobacter and Propionibacterium...
March 2, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28250801/press-pulse-a-novel-therapeutic-strategy-for-the-metabolic-management-of-cancer
#15
Thomas N Seyfried, George Yu, Joseph C Maroon, Dominic P D'Agostino
BACKGROUND: A shift from respiration to fermentation is a common metabolic hallmark of cancer cells. As a result, glucose and glutamine become the prime fuels for driving the dysregulated growth of tumors. The simultaneous occurrence of "Press-Pulse" disturbances was considered the mechanism responsible for reduction of organic populations during prior evolutionary epochs. Press disturbances produce chronic stress, while pulse disturbances produce acute stress on populations. It was only when both disturbances coincide that population reduction occurred...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28239404/impact-of-a-6-week-non-energy-restricted-ketogenic-diet-on-physical-fitness-body-composition-and-biochemical-parameters-in-healthy-adults
#16
Paul Urbain, Lena Strom, Lena Morawski, Anja Wehrle, Peter Deibert, Hartmut Bertz
BACKGROUND: The ketogenic diet (KD) is a very low-carbohydrate, high-fat and adequate-protein diet that without limiting calories induces different metabolic adaptations, eg, increased levels of circulating ketone bodies and a shift to lipid metabolism. Our objective was to assess the impact of a 6-week non-energy-restricted KD in healthy adults beyond cohorts of athletes on physical performance, body composition, and blood parameters. METHODS: Our single arm, before-and-after comparison study consisted of a 6-week KD with a previous preparation period including detailed instructions during classes and individual counselling by a dietitian...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28132874/glycation-inhibitors-extend-yeast-chronological-lifespan-by-reducing-advanced-glycation-end-products-and-by-back-regulation-of-proteins-involved-in-mitochondrial-respiration
#17
Rubina S Kazi, Reema M Banarjee, Arati B Deshmukh, Gouri V Patil, Mashanipalya G Jagadeeshaprasad, Mahesh J Kulkarni
Advanced Glycation End products (AGEs) are implicated in aging process. Thus, reducing AGEs by using glycation inhibitors may help in attenuating the aging process. In this study using Saccharomyces cerevisiae yeast system, we show that Aminoguanidine (AMG), a well-known glycation inhibitor, decreases the AGE modification of proteins in non-calorie restriction (NR) (2% glucose) and extends chronological lifespan (CLS) similar to that of calorie restriction (CR) condition (0.5% glucose). Proteomic analysis revealed that AMG back regulates the expression of differentially expressed proteins especially those involved in mitochondrial respiration in NR condition, suggesting that it switches metabolism from fermentation to respiration, mimicking CR...
March 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28109411/the-challenge-in-improving-the-diets-of-supplemental-nutrition-assistance-program-recipients-a-historical-commentary
#18
EDITORIAL
Barry M Popkin
This paper provides a historical background for the current nutrition issues faced by the Supplemental Nutrition Assistance Program (SNAP). The Food Stamp Program evolved into SNAP during a period when U.S. diets, particularly those of the poor, became less healthful. During the 1960s, the U.S. (Kennedy-Johnson era) addressed malnutrition first with a pilot project focused on retail sales and cash food stamps, which showed that low-income consumers purchased relatively healthy foods for a fairly high-quality diet...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28090338/executive-functions-predict-weight-loss-in-a-medically-supervised-weight-loss-programme
#19
R Galioto, D Bond, J Gunstad, V Pera, L Rathier, G Tremont
BACKGROUND: Deficits in executive functions are related to poorer weight loss after bariatric surgery; however, less is known about the role that these deficits may play during participation in nonsurgical weight loss programmes. This study examined associations between objectively measured executive functions and weight loss during participation in a medically supervised weight loss programme. METHODS: Twenty-three adult patients (age 50.4 ± 15.1, BMI 44.2 ± 8...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28025637/effect-of-48%C3%A2-h-fasting-on-autonomic-function-brain-activity-cognition-and-mood-in-amateur-weight-lifters
#20
Rima Solianik, Artūras Sujeta, Asta Terentjevienė, Albertas Skurvydas
Objectives. The acute fasting-induced cardiovascular autonomic response and its effect on cognition and mood remain debatable. Thus, the main purpose of this study was to estimate the effect of a 48 h, zero-calorie diet on autonomic function, brain activity, cognition, and mood in amateur weight lifters. Methods. Nine participants completed a 48 h, zero-calorie diet program. Cardiovascular autonomic function, resting frontal brain activity, cognitive performance, and mood were evaluated before and after fasting...
2016: BioMed Research International
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