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https://www.readbyqxmd.com/read/28293018/exploring-the-relationship-between-%C3%AE-actinin-3-deficiency-and-obesity-in-mice-and-humans
#1
P J Houweling, Y D Berman, N Turner, K G R Quinlan, J T Seto, N Yang, M Lek, D G Macarthur, G Cooney, K N North
Obesity is a worldwide health crisis and the identification of genetic modifiers of weight gain is crucial in understanding this complex disorder. A common null polymorphism in the fast fiber-specific gene ACTN3 (R577X) is known to influence skeletal muscle function and metabolism. α-Actinin-3 deficiency occurs in an estimated 1.5 billion people worldwide, and results in reduced muscle strength and a shift towards a more efficient oxidative metabolism. The X-allele has undergone strong positive selection during recent human evolution and in this study we sought to determine whether ACTN3 genotype influences weight gain and obesity in mice and humans...
March 15, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28277962/oxidative-challenges-of-avian-migration-a-comparative-field-study-on-a-partial-migrant
#2
Cas Eikenaar, Emma Källstig, Martin N Andersson, Amparo Herrera-Dueñas, Caroline Isaksson
Most avian migrants alternate flight bouts, characterized by high metabolic rates, with stopovers, periods of fuel replenishment through hyperphagia. High-energy metabolism and excessive calorie intake shift the balance between damaging prooxidants and antioxidants toward the former. Hence, migration likely affects the oxidative balance of birds. Migratory flight indeed appears to cause oxidative damage; however, whether migration affects the oxidative state of birds at stopover is unclear. Therefore, we compared total nonenzymatic antioxidant capacity (AOX) and malondialdehyde concentration (MDA; a measure of lipid peroxidation) in the plasma of migrant and resident common blackbirds...
March 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28264001/a-camera-phone-based-study-reveals-erratic-eating-pattern-and-disrupted-daily-eating-fasting-cycle-among-adults-in-india
#3
Neelu Jain Gupta, Vinod Kumar, Satchidananda Panda
The daily rhythm of feeding-fasting and meal-timing are emerging as important determinants of health. Circadian rhythm research in animal models and retrospective analyses of human nutrition data have shown that reduced length of overnight fasting or increased late night eating increases risk for metabolic diseases including obesity and diabetes. However, the daily rhythm in eating pattern in humans is rarely measured. Traditional methods to collect nutrition information through food diary and food log pay little attention to the timing of eating which may also change from day to day...
2017: PloS One
https://www.readbyqxmd.com/read/28251799/diet-affects-arctic-ground-squirrel-gut-microbial-metatranscriptome-independent-of-community-structure
#4
Jasmine J Hatton, Timothy J Stevenson, C Loren Buck, Khrystyne N Duddleston
We examined the effect of diet on pre-hibernation fattening and the gut microbiota of captive arctic ground squirrels (Urocitellus parryii). We measured body composition across time and gut microbiota density, diversity, and function prior to and after five-weeks on control, high-fat, low-fat (18%, 40%, and 10% energy from fat, respectively), or restricted calorie (50% of control) diets. Squirrels fattened at the same rate and to the same degree on all diets. Additionally, we found no differences in gut microbiota diversity or short chain fatty acid production across time or with diet...
March 2, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28251782/one-year-calorie-restriction-impacts-gut-microbial-composition-but-not-its-metabolic-performance-in-obese-adolescents
#5
Alicia Ruiz, Tomás Cerdó, Ruy Jáuregui, Dietmar H Pieper, Ascensión Marcos, Alfonso Clemente, Federico García, Abelardo Margolles, Manuel Ferrer, Cristina Campoy, Antonio Suárez
Recent evidence has disclosed a connection between gut microbial glycosidase activity and adiposity in obese. Here, we measured microbial α-glucosidase and β-galactosidase activities and sorted fluorescently labeled β-galactosidase containing (βGAL) microorganisms in faecal samples of eight lean and thirteen obese adolescents that followed a controlled calorie restriction program during one year. β-galactosidase is a highly distributed functional trait, mainly expressed by members of Blautia, Bacteroides, Alcaligenes, Acinetobacter and Propionibacterium...
March 2, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28250801/press-pulse-a-novel-therapeutic-strategy-for-the-metabolic-management-of-cancer
#6
Thomas N Seyfried, George Yu, Joseph C Maroon, Dominic P D'Agostino
BACKGROUND: A shift from respiration to fermentation is a common metabolic hallmark of cancer cells. As a result, glucose and glutamine become the prime fuels for driving the dysregulated growth of tumors. The simultaneous occurrence of "Press-Pulse" disturbances was considered the mechanism responsible for reduction of organic populations during prior evolutionary epochs. Press disturbances produce chronic stress, while pulse disturbances produce acute stress on populations. It was only when both disturbances coincide that population reduction occurred...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28239404/impact-of-a-6-week-non-energy-restricted-ketogenic-diet-on-physical-fitness-body-composition-and-biochemical-parameters-in-healthy-adults
#7
Paul Urbain, Lena Strom, Lena Morawski, Anja Wehrle, Peter Deibert, Hartmut Bertz
BACKGROUND: The ketogenic diet (KD) is a very low-carbohydrate, high-fat and adequate-protein diet that without limiting calories induces different metabolic adaptations, eg, increased levels of circulating ketone bodies and a shift to lipid metabolism. Our objective was to assess the impact of a 6-week non-energy-restricted KD in healthy adults beyond cohorts of athletes on physical performance, body composition, and blood parameters. METHODS: Our single arm, before-and-after comparison study consisted of a 6-week KD with a previous preparation period including detailed instructions during classes and individual counselling by a dietitian...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28132874/glycation-inhibitors-extend-yeast-chronological-lifespan-by-reducing-advanced-glycation-end-products-and-by-back-regulation-of-proteins-involved-in-mitochondrial-respiration
#8
Rubina S Kazi, Reema M Banarjee, Arati B Deshmukh, Gouri V Patil, Mashanipalya G Jagadeeshaprasad, Mahesh J Kulkarni
Advanced Glycation End products (AGEs) are implicated in aging process. Thus, reducing AGEs by using glycation inhibitors may help in attenuating the aging process. In this study using Saccharomyces cerevisiae yeast system, we show that Aminoguanidine (AMG), a well-known glycation inhibitor, decreases the AGE modification of proteins in non-calorie restriction (NR) (2% glucose) and extends chronological lifespan (CLS) similar to that of calorie restriction (CR) condition (0.5% glucose). Proteomic analysis revealed that AMG back regulates the expression of differentially expressed proteins especially those involved in mitochondrial respiration in NR condition, suggesting that it switches metabolism from fermentation to respiration, mimicking CR...
March 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28109411/the-challenge-in-improving-the-diets-of-supplemental-nutrition-assistance-program-recipients-a-historical-commentary
#9
EDITORIAL
Barry M Popkin
This paper provides a historical background for the current nutrition issues faced by the Supplemental Nutrition Assistance Program (SNAP). The Food Stamp Program evolved into SNAP during a period when U.S. diets, particularly those of the poor, became less healthful. During the 1960s, the U.S. (Kennedy-Johnson era) addressed malnutrition first with a pilot project focused on retail sales and cash food stamps, which showed that low-income consumers purchased relatively healthy foods for a fairly high-quality diet...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28090338/executive-functions-predict-weight-loss-in-a-medically-supervised-weight-loss-programme
#10
R Galioto, D Bond, J Gunstad, V Pera, L Rathier, G Tremont
BACKGROUND: Deficits in executive functions are related to poorer weight loss after bariatric surgery; however, less is known about the role that these deficits may play during participation in nonsurgical weight loss programmes. This study examined associations between objectively measured executive functions and weight loss during participation in a medically supervised weight loss programme. METHODS: Twenty-three adult patients (age 50.4 ± 15.1, BMI 44.2 ± 8...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28025637/effect-of-48%C3%A2-h-fasting-on-autonomic-function-brain-activity-cognition-and-mood-in-amateur-weight-lifters
#11
Rima Solianik, Artūras Sujeta, Asta Terentjevienė, Albertas Skurvydas
Objectives. The acute fasting-induced cardiovascular autonomic response and its effect on cognition and mood remain debatable. Thus, the main purpose of this study was to estimate the effect of a 48 h, zero-calorie diet on autonomic function, brain activity, cognition, and mood in amateur weight lifters. Methods. Nine participants completed a 48 h, zero-calorie diet program. Cardiovascular autonomic function, resting frontal brain activity, cognitive performance, and mood were evaluated before and after fasting...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27874078/glutamate-dehydrogenase-activator-bch-stimulating-reductive-amination-prevents-high-fat-high-fructose-diet-induced-steatohepatitis-and-hyperglycemia-in-c57bl-6j-mice
#12
Seung Jin Han, Sung-E Choi, Sang-A Yi, Jong Gab Jung, Ik-Rak Jung, Maureen Shin, Seok Kang, Hyunhee Oh, Hae Jin Kim, Dae Jung Kim, Ji Eun Kwon, Cheol Soo Choi, Kwan Woo Lee, Yup Kang
Individuals with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) induced by high calorie western diet are characterized by enhanced lipogenesis and gluconeogenesis in the liver. Stimulation of reductive amination may shift tricarboxylic acid cycle metabolism for lipogenesis and gluconeogenesis toward glutamate synthesis with increase of NAD+/NADH ratio and thus, ameliorate high calorie diet-induced fatty liver and hyperglycemia. Stimulation of reductive amination through glutamate dehydrogenase (GDH) activator 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) reduced both de novo lipogenesis and gluconeogenesis but increased the activities of sirtuins and AMP-activated kinase in primary hepatocytes...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869525/oxidative-priority-meal-frequency-and-the-energy-economy-of-food-and-activity-implications-for-longevity-obesity-and-cardiometabolic-disease
#13
Raymond J Cronise, David A Sinclair, Andrew A Bremer
In most modern societies, the relationship that many individuals have with food has fundamentally changed from previous generations. People have shifted away from viewing food as primarily sustenance, and rather now seek out foods based on pure palatability or specific nutrition. However, it is far from clear what optimal nutrition is for the general population or specific individuals. We previously described the Food Triangle as a way to organize food based on an increasing energy density paradigm, and now expand on this model to predict the impact of oxidative priority and both nutrient and fiber density in relation to caloric load...
February 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27799519/piperine-s-mitigation-of-obesity-and-diabetes-can-be-explained-by-its-up-regulation-of-the-metabolic-rate-of-resting-muscle
#14
Leonardo Nogara, Nariman Naber, Edward Pate, Marcella Canton, Carlo Reggiani, Roger Cooke
We identify a target for treating obesity and type 2 diabetes, the consumption of calories by an increase in the metabolic rate of resting skeletal muscle. The metabolic rate of skeletal muscle can be increased by shifting myosin heads from the super-relaxed state (SRX), with a low ATPase activity, to a disordered relaxed state (DRX), with a higher ATPase activity. The shift of myosin heads was detected by a change in fluorescent intensity of a probe attached to the myosin regulatory light chain in skinned skeletal fibers, allowing us to perform a high-throughput screen of 2,128 compounds...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27713085/the-effect-of-high-fat-diet-consumption-on-appetitive-instrumental-behavior-in-rats
#15
Frédéric Tantot, Shauna L Parkes, Alain R Marchand, Chloé Boitard, Fabien Naneix, Sophie Layé, Pierre Trifilieff, Etienne Coutureau, Guillaume Ferreira
Evidence now indicates that the chronic consumption of high-calorie foods, such as a high-fat diet (HFD), is associated with impaired control over food-seeking, yet the extent of this alteration is not fully understood. Using different reinforcement schedules, we evaluated whether HFD intake from weaning to adulthood modifies instrumental responding and induces a shift from goal-directed actions to habitual responding. We first observed reduced instrumental performance and motivation for a food reward in HFD-fed rats trained under schedules of reinforcement that facilitate habitual responding [Random Interval (RI)]...
January 1, 2017: Appetite
https://www.readbyqxmd.com/read/27708847/lifestyle-modification-intervention-improves-glycemic-control-in-mongolian-adults-who-are-overweight-or-obese-with-newly-diagnosed-type-2-diabetes
#16
S Sonomtseren, Y Sankhuu, J D Warfel, D L Johannsen, C M Peterson, B Vandanmagsar
OBJECTIVE: To evaluate the effectiveness of a weight loss intervention in Mongolian adults with newly diagnosed type 2 diabetes mellitus and with BMIs ≥ 25.0 kg/m(2). METHODS: Eighty participants (33 men/47 women) aged 32-56 years old received education sessions to improve nutritional habits and increase physical activity. Participants were counselled in-person on two occasions with regular follow-up by phone to eat less (reduce calorie intake by 30-40% and consume fewer fatty foods), shift food intake to earlier in a day and increase physical activity such as walking, jogging, running and biking...
September 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27615385/short-term-benefits-of-an-unrestricted-calorie-traditional-mediterranean-diet-modified-with-a-reduced-consumption-of-carbohydrates-at-evening-in-overweight-obese-patients
#17
Roberto Salvia, Simona D'Amore, Giusi Graziano, Caterina Capobianco, Moris Sangineto, Domenico Paparella, Paola de Bonfils, Giuseppe Palasciano, Michele Vacca
The Mediterranean diet (MeD) is believed to promote health; nevertheless, changes in the nutritional patterns in the Mediterranean area (increased intake of refined carbohydrates/saturated fats; reduced fibers intake; main calorie load shifted to dinner) led to reduced MeD benefits in recent decades. We retrospectively investigated the effects of a MeD with a low intake of refined carbohydrates in the evening ("MeDLowC") on body weight (BW) and metabolic profile of overweight/obese subjects. According to their adherence to MeDLowC, subjects were classified into 44 (41%) individuals with "excellent" adherence and 63 (59%) with "poor" adherence...
September 12, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27610001/universal-food-security-program-and-nutritional-intake-evidence-from-the-hunger-prone-kbk-districts-in-odisha
#18
Andaleeb Rahman
This article provides evidence on the role of consumer food subsidies in improving nutritional intake and diet quality by evaluating the expansion of the government food assistance program coverage in the hunger prone state of Odisha in India. In 8 districts of Odisha, popularly known as the Kalahandi-Balangir-Koraput (KBK) region which is notable for extreme poverty and starvation deaths, the government did away with the targeted food assistance program in 2008 and made the scheme universal. Using a Difference-in-Difference methodology over two repeated cross sectional household surveys, this article finds that the shift from targeted to a universal food security program in the KBK region of Odisha has led to an improvement in the household nutritional intake and diet quality...
August 2016: Food Policy
https://www.readbyqxmd.com/read/27595380/what-is-the-manner-of-gastric-emptying-after-ingestion-of-liquids-with-differences-in-the-volume-under-uniform-glucose-based-energy-content
#19
Tadashi Okabe, Hideo Terashima, Atsuhiro Sakamoto
BACKGROUND & AIMS: We previously demonstrated that the gastric emptying rate of liquids chiefly depended on the total amount of calories (energy content) in a uniform volume. The aim of the present study was to examine the effects of different volumes of liquids with a uniform energy content on gastric emptying. METHODS: Three types of test solutions were prepared with a uniform amount of calories (200 kcal provided by glucose) and step-wise increments in volume (200 ml, 400 ml, and 600 ml)...
August 24, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27529061/the-role-of-adipokines-in-chronic-inflammation
#20
REVIEW
Peter Mancuso
Adipose tissue has traditionally been defined as connective tissue that stores excess calories in the form of triacylglycerol. However, the physiologic functions attributed to adipose tissue are expanding, and it is now well established that adipose tissue is an endocrine gland. Among the endocrine factors elaborated by adipose tissue are the adipokines; hormones, similar in structure to cytokines, produced by adipose tissue in response to changes in adipocyte triacylglycerol storage and local and systemic inflammation...
2016: ImmunoTargets and Therapy
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