Michael Li, Jacob Macro, Kali Meadows, Dushyant Mishra, Dominique Martin, Sara Olson, Billy Joe Huggins, Brenton R Graveley, James Y H Li, Blanka Rogina
The prevalence of obesity is increasing in older adults and contributes to age-related decline. Caloric restriction (CR) alleviates obesity phenotypes and delays the onset of age-related changes. However, how late in life organisms benefit from switching from a high-(H) to a low-calorie (L) diet is unclear. We transferred male flies from a H to a L (HL) diet or vice versa (LH) at different times during life. Both shifts immediately change fly rate of aging even when applied late in life. HL shift rapidly reduces fly mortality rate to briefly lower rate than in flies on a constant L diet, and extends lifespan...
December 12, 2023: Proceedings of the National Academy of Sciences of the United States of America