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https://www.readbyqxmd.com/read/28146595/pediatric-diabetes-outpatient-center-at-rhode-island-hospital-the-impact-of-changing-initial-diabetes-education-from-inpatient-to-outpatient
#1
Mia M Pingul, Erin M Mulvihill, Steven E Reinert, Geetha Gopalakrishnan, Wendy A Plante, Charlotte M Boney, Shara R Bialo, Jose Bernardo Quintos
BACKGROUND: This study compared outcomes and costs for new-onset Type 1 diabetes mellitus (T1DM) patients educated at the outpatient versus inpatient settings. METHODS/DESIGN: Retrospective study examining the following variables: 1) hemoglobin A1c (HbA1c), 2) severe hypoglycemia, 3) admissions for diabetic ketoacidosis (DKA) or ER visits, and 4) healthcare cost. RESULTS: 152 patients with new-onset T1DM from September 2007-August 2009. There were no differences between outpatient group (OG) and inpatient group (IG) in mean HbA1c levels at 1, 2 and 3 years post-diagnosis (OG 8%, 8...
February 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28141731/growth-and-documentation-deficits-where-to-start-in-helping-families
#2
Wilhelmina Hernandez, Deborah A Frank, Samantha Morton, Carmen Palacios, Marilyn Augustyn
Pedro is a 2-year 7-month-old boy who was presented for the first time after a visit to a local emergency room (ER) for diarrhea. At the time of his birth, his undocumented mother, Clara, was 20 years old, uninsured, and with limited English proficiency living approximately 400 miles south of our practice in a different state. Although she had been brought to the United States as a child, she had never finished high school. Pedro was born what mother thought was full-term at his parent's home, where a lay midwife assisted during the delivery...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28139061/immunohistochemical-and-molecular-profile-of-salivary-gland-cancer-in-children
#3
Laura D Locati, Paola Collini, Martina Imbimbo, Marta Barisella, Adele Testi, Lisa F Licitra, Thomas Löning, Katharina Tiemann, Pasquale Quattrone, Emanuela Bimbatti, Stefano Chiaravalli, Michela Casanova, Elena Tamborini, Roberto Carta, Patrizia Gasparini, Marco Guzzo, Maura Massimino, Andrea Ferrari
BACKGROUND: Pediatric salivary gland carcinomas (SGCs) are very rare. They differ from the adult SGCs in terms of epidemiologic and clinical behavior, being generally limited only to selected histotypes (e.g. low-grade mucoepidermoid [LG-MEC] and acinic cell cancer [AcCC]) and characterized by very good outcome. Our aim was to investigate therapeutic targets on a series of pediatric SGCs by immunohistochemical and molecular analysis. METHODS: A retrospective analysis was performed to search for cases of pediatric SGCs in the database of the Pediatric Oncology Unit at the Istituto Nazionale Tumori and in the Pathology database at the Gerhard-Seifert-Reference-Centre...
January 31, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28138820/development-of-extended-release-oral-flexible-tablet-er-oft-formulation-for-pediatric-and-geriatric-compliance-an-age-appropriate-formulation
#4
Prabagaran Chandrasekaran, Ruckmani Kandasamy
Development of age-appropriate formulation suitable for pediatric and geriatric patients involves various challenges. The objective of this research was to develop extended-release oral flexible tablet (ER-OFT) formulation using carbamazepine (CBZ) as model drug for pediatric and geriatric compliance. ER-microparticles of carbamazepine, a BCS class 2, and narrow therapeutic index (NTI) drug, were prepared using ethyl cellulose as matrixing polymer and hypromellose as hydrophilic pore former. Microparticles were prepared using high-shear granulator fitted with an atomizing spray system...
January 30, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28103959/validation-of-a-case-definition-for-pediatric-brain-injury-using-administrative-data
#5
Jane McChesney-Corbeil, Karen Barlow, Hude Quan, Guanmin Chen, Samuel Wiebe, Nathalie Jette
BACKGROUND: Health administrative data are a common population-based data source for traumatic brain injury (TBI) surveillance and research; however, before using these data for surveillance, it is important to develop a validated case definition. The objective of this study was to identify the optimal International Classification of Disease , edition 10 (ICD-10), case definition to ascertain children with TBI in emergency room (ER) or hospital administrative data. We tested multiple case definitions...
January 20, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28050641/children-presenting-in-delayed-fashion-after-minor-head-trauma-with-scalp-swelling-do-they-require-further-workup
#6
Jonathan N Sellin, Amee Moreno, Sheila L Ryan, Sandi K Lam, Marcella Donaruma-Kwoh, Thomas G Luerssen, Andrew Jea
PURPOSE: It is common to evaluate children who have sustained minor head trauma with computed tomography (CT) of the head. Scalp swelling, in particular, has been associated with intracranial injury. A subset of patients, however, present in delayed fashion, often days after the head trauma, as soft tissue edema progresses and their caregiver notices scalp swelling. We explore the value of further workup in this setting. METHODS: We conducted a retrospective review of a prospectively collected cohort of children ≤24 months of age presenting to the Texas Children's Hospital with scalp swelling more than 24 h following a head trauma...
January 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27909943/simulating-different-dosing-scenarios-for-a-child-appropriate-valproate-er-formulation-in-a-new-pediatric-two-stage-dissolution-model
#7
Frank Karkossa, Antonia Krueger, Jana Urbaniak, Sandra Klein
Predictive in vitro test methods addressing the parameters relevant to drug release in the pediatric gastrointestinal tract could be an appropriate means for reducing the number of in vivo studies in children. However, dissolution models addressing the particular features of pediatric gastrointestinal physiology and typical pediatric dosing scenarios have not yet been described. The objective of the present study was to combine the knowledge on common vehicle types and properties and current information on pediatric gastrointestinal physiology to design a dissolution model that enables a biorelevant simulation of the gastrointestinal conditions in young children...
February 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27771222/analyses-of-demographical-and-injury-characteristics-of-adult-and-pediatric-patients-injured-in-syrian-civil-war
#8
Erhan Er, Şeref Kerem Çorbacıoğlu, Sertaç Güler, Şahin Aslan, Meltem Seviner, Gökhan Aksel, Burak Bekgöz
PURPOSE: Aimed to analyze demographical data and injury characteristics of patients who were injured in the Syrian Civil War (SCW) and to define differences in injury characteristics between adult and pediatric patients. METHODOLOGY: Patients who were injured in the SCW and transferred to our emergency department were retrospectively analyzed in this study during the 15-month period between July 2013 and October 2014. RESULTS: During the study period, 1591 patients who were the victims of the SCW and admitted to our emergency department due to war injury enrolled in the study...
January 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27618636/low-rates-of-pregnancy-screening-in-adolescents-before-teratogenic-exposures-in-a-national-sample-of-children-s-hospitals
#9
Pooja Rao, Yimei Li, Kelly D Getz, Tamara P Miller, Yuan-Shung Huang, Jennifer J Wilkes, Alix E Seif, Rochelle Bagatell, Brian T Fisher, Clarisa Gracia, Richard Aplenc
BACKGROUND: Adolescents with cancer engage in sexual behaviors and are exposed to teratogenic chemotherapy. There are no data regarding pregnancy screening patterns for adolescents before chemotherapy exposure. METHODS: A cross-sectional study of leukemia and emergency room (ER) admissions in the Pediatric Health Information System from 1999 to 2011 was conducted. Females who were 10 to 18 years old and 1) had newly diagnosed acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) or 2) had ER visits with computed tomography (CT) of the abdomen/pelvis were included...
September 12, 2016: Cancer
https://www.readbyqxmd.com/read/27598444/fractional-laser-assisted-topical-imiquimod-5-cream-treatment-for-recalcitrant-common-warts-in-children-a-pilot-study
#10
Sung-Min Park, Gun-Wook Kim, Je-Ho Mun, Margaret Song, Hoon-Soo Kim, Byung-Soo Kim, Moon-Bum Kim, Hyun-Chang Ko
BACKGROUND: Conventional treatments for warts like cryotherapy are limited by the pain during procedures, especially in pediatric patients. Imiquimod is a topical immune response modifier, but the thick stratum corneum of common warts prevents drug permeation through skin. OBJECTIVE: To evaluate the efficacy and safety of fractional laser/topical 5% imiquimod cream for the treatment of warts in children. METHODS: Eleven pediatric patients with multiple recalcitrant common warts were included...
December 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27575889/seven-day-cumulative-effects-of-air-pollutants-increase-respiratory-er-visits-up-to-threefold
#11
Cláudio Schvartsman, Luiz Alberto Amador Pereira, Alfésio Luiz Ferreira Braga, Sylvia Costa Lima Farhat
OBJECTIVE: Children are especially vulnerable to respiratory injury induced by exposure to air pollutants. In the present study, we investigate periods of up to 7 days, and evaluate the lagged effects of exposure to air pollutants on the daily number of children and adolescents visiting the emergency room (ER) for the treatment of lower respiratory obstructive diseases (LROD), in the city of São Paulo, Brazil. METHODS: Daily records of LROD-related ER visits by children and adolescents under the age of 19, from January 2000 to December 2007 (2,922 days) were included in the study...
August 29, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27507228/long-term-safety-efficacy-pharmacokinetics-and-pharmacodynamics-of-omalizumab-in-children-with-severe-uncontrolled-asthma
#12
MULTICENTER STUDY
Hiroshi Odajima, Motohiro Ebisawa, Toshikazu Nagakura, Takao Fujisawa, Akira Akasawa, Komei Ito, Satoru Doi, Koichi Yamaguchi, Toshio Katsunuma, Kazuyuki Kurihara, Takahide Teramoto, Kazuko Sugai, Mitsuhiko Nambu, Akira Hoshioka, Shigemi Yoshihara, Norio Sato, Noriko Seko, Sankei Nishima
BACKGROUND: Omalizumab is effective and well-tolerated in children with moderate to severe allergic asthma. However, the effects of long-term treatment with omalizumab in this population haven't been well investigated. The objective of this study is to evaluate the long-term safety, efficacy, pharmacokinetics and pharmacodynamics of omalizumab in children with uncontrolled severe asthma. METHODS: Thirty-eight Japanese children (aged 7-16 years) who completed the 24-week treatment core study were included in an uncontrolled extension study, in which treatment with omalizumab continued until the pediatric indication was approved in Japan (ClinicalTrials...
January 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27493829/evaluation-of-er-cr-ysgg-laser-effect-on-microshear-bond-strength-of-a-self-adhesive-flowable-composite-in-the-dentin-of-permanent-molar-an-in-vitro-study
#13
Masoumeh Moslemi, Faezeh Fotouhi Ardakani, Fatemeh Javadi, Zahra Khalili Sadrabad, Zahra Shadkar, Mohammad Saeid Shadkar
Aim and Background. Recently, new restorative materials such as self-adhesive flowable composites, because of their simple use and no need to bonding and etching, are considered important, particularly in pediatric dentistry. The aim of this study is to evaluate the effect of Er,Cr:YSGG laser on microshear bond strength of self-adhesive flowable composite on permanent teeth dentin in vitro. Material and Methods. In this experimental study, 40 dentin sections were prepared from healthy third molars and divided into two groups according to their surface preparation by Er,Cr:YSGG laser or without laser, only with silicon carbide paper...
2016: Scientifica
https://www.readbyqxmd.com/read/27492006/air-pollution-aeroallergens-and-admissions-to-pediatric-emergency-room-for-respiratory-reasons-in-turin-northwestern-italy
#14
Roberto Bono, Valeria Romanazzi, Valeria Bellisario, Roberta Tassinari, Giulia Trucco, Antonio Urbino, Claudio Cassardo, Consolata Siniscalco, Pierpaolo Marchetti, Alessandro Marcon
BACKGROUND: Air pollution can cause respiratory symptoms or exacerbate pre-existing respiratory diseases, especially in children. This study looked at the short-term association of air pollution concentrations with Emergency Room (ER) admissions for respiratory reasons in pediatric age (0-18 years). METHODS: Daily number of ER admissions in a children's Hospital, concentrations of urban-background PM2.5, NO2, O3 and total aeroallergens (Corylaceae, Cupressaceae, Gramineae, Urticaceae, Ambrosia, Betula) were collected in Turin, northwestern Italy, for the period 1/08/2008 to 31/12/2010 (883 days)...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27413479/tapentadol-can-it-kill-two-birds-with-one-stone-without-breaking-windows
#15
REVIEW
Eun Jung Chang, Eun Ji Choi, Kyung Hoon Kim
Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the µ-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys...
July 2016: Korean Journal of Pain
https://www.readbyqxmd.com/read/27368442/pediatric-adenotonsillectomy-and-postoperative-hemorrhage-demographic-and-geographic-variation-in-the-us
#16
Jonathan A Harounian, Eric Schaefer, Jane Schubart, Michele M Carr
OBJECTIVE: To examine demographic and regional variations in pediatric tonsillectomy, with or without adenoidectomy, and post-tonsillectomy hemorrhage on a national level. METHODS: The MarketScan(®) database was analyzed for claims made between 2008-2012 for the 30 days following tonsillectomy/adenotonsillectomy in privately insured children 1-17 years of age. RESULTS: We analyzed 305,860 patients with 98.6% of these tonsillectomies occurring in an ambulatory setting...
August 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27350621/switching-from-immediate-to-extended-release-cysteamine-in-nephropathic-cystinosis-patients-a-retrospective-real-life-single-center-study
#17
Thurid Ahlenstiel-Grunow, Nele K Kanzelmeyer, Kerstin Froede, Martin Kreuzer, Jens Drube, Christian Lerch, Lars Pape
BACKGROUND: Nephropathic cystinosis is a rare lysosomal storage disease which is characterized by the accumulation of free cystine in lysosomes and subsequent intracellular crystal formation of cystine throughout the body. If not treated with cysteamine, a cystine-depleting agent, end-stage renal disease will develop early, followed by multiple organ failure as the disease progresses. The established cysteamine formulation requires a strict dosing regimen at 6-h intervals. An extended release (ER) twice-daily formulation has recently been developed...
June 27, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27343004/redesign-and-validation-of-sisom-an-interactive-assessment-and-communication-tool-for-children-with-cancer
#18
Susann Arvidsson, Britt-Mari Gilljam, Jens Nygren, Cornelia Maria Ruland, Trude Nordby-Bøe, Petra Svedberg
BACKGROUND: Children with cancer undergo intensive and long treatment periods that expose them and their families to a number of difficult physical, mental, and social challenges. Empowering children by actively involving them in their care can help them to cope with these challenges. It can, however, be difficult for children to be involved and talk about their illness experiences in a "traditional" conversation with health care professionals, especially for younger children. Sisom (Norwegian acronym "Si det som det er" or "Tell it how it is") is an interactive computer-based assessment and communication tool to give children (aged 6-12 years) with cancer a "voice" in their care...
2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27315242/profiling-the-patients-visiting-the-emergency-room-for-musculoskeletal-complaints-characteristics-and-outcomes
#19
Mattia Bellan, Rossella Molinari, Luigi Castello, Daniele Sola, Antonello Gibbin, Giulia Guaschino, Roberta Pedrazzoli, Alessia Puma, Mario Pirisi, Gian Carlo Avanzi, Pier Paolo Sainaghi
Non-traumatic musculoskeletal complaints are often dealt with by emergency room (ER) physicians. We aimed to quantify how many patients with such complaints have conditions requiring immediate recognition and treatment, versus specialist referral, versus primary care. We retrieved the clinical records of all the patients admitted to the ER department of our hospital along 1 year. Pediatric (age <14 years) and obstetrics/gynecology cases were excluded. Data from all patients visiting the ER for non-traumatic musculoskeletal complaints were classified as follows: true emergencies (i...
November 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27274841/caregiver-word-reading-literacy-and-health-outcomes-among-children-treated-in-a-pediatric-nephrology-practice
#20
Eniko C Rak, Stephen R Hooper, Michael J Belsante, Otis Burnett, Bradley Layton, David Tauer, Bradley Mantoo, Darren DeWalt, Maria E Ferris
BACKGROUND: Caregivers play a major role in the healthcare of pediatric patients, particularly during childhood and adolescence. This study examined the impact of caregivers' functional literacy on the health outcomes of adolescents with chronic kidney disease (CKD) or end-stage kidney disease (ESKD). METHODS: Caregiver-child dyads in a Southeastern US pediatric nephrology clinic participated in this cross-sectional study. We collected demographic information, data on caregivers' functional literacy skills (Wechsler Individual Achievement Test Word Reading Subtest) and child health outcomes (healthcare utilization and adherence)...
June 2016: Clinical Kidney Journal
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