Jessica D Murillo-Saich, Roxana Coras, Julio Ramirez, Estefania Quesada-Masachs, Marta Sala-Climent, Katharina Eschelbach, Christopher B Mahony, Raquel Celis, Aaron Armando, Oswald Quehenberger, Adam P Croft, Arthur Kavanaugh, Eric Chang, Juan D Cañete, Abha Singh, Monica Guma
OBJECTIVE: Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFAs) that modulate inflammation and may remain overexpressed in refractory synovitis. In plasma, they could also be biomarkers of synovial pathology. The aim of this study is to determine if synovial oxylipins in inflamed joints correlate with plasma oxylipins and with synovial histological patterns. METHODS: Patients with established rheumatoid or psoriatic arthritis with active disease despite treatment were recruited and paired ST and plasma were collected...
March 20, 2024: Arthritis & Rheumatology