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https://www.readbyqxmd.com/read/29344167/analysis-of-imp3-expression-in-primary-tumor-and-stromal-cells-in-patients-with-colorectal-cancer
#1
Xiaoping Huang, Qingzhu Wei, Jianghuan Liu, Hongling Niu, Gang Xiao, Lixin Liu
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein upregulated in tumor cells during carcinogenesis. The aim of the present study was to investigate the expression status of IMP3 in colorectal cancer (CRC) tissues and its clinical significance. Immunostaining was performed in 130 CRC samples, the association of IMP3 expression with clinicopathological characteristics was assessed and 58 patients were selected for survival analysis. To the best of our knowledge, the present study describes for the first time the expression of IMP3 in tumor stromal components of CRC...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29313948/human-dendritic-cell-subsets-an-update
#2
REVIEW
Matthew Collin, Venetia Bigley
Dendritic cells (DC) are a class of bone marrow derived cells arising from lympho-myeloid haematopoiesis that form an essential interface between the innate sensing of pathogens and the activation of adaptive immunity. This task requires a wide range of mechanisms and responses, which are divided between three major DC subsets: plasmacytoid DC (pDC), myeloid/conventional DC1 (cDC1) and myeloid/conventional DC2 (cDC2). Each DC subset develops under the control of a specific repertoire of transcription factors involving differential levels of IRF8 and IRF4 in collaboration with PU...
January 3, 2018: Immunology
https://www.readbyqxmd.com/read/29290995/effectiveness-of-adjuvant-systemic-chemotherapy-for-intermediate-risk-stage-ib-cervical-cancer
#3
Koji Matsuo, Muneaki Shimada, Harushige Yokota, Toyomi Satoh, Hidetaka Katabuchi, Shoji Kodama, Hiroshi Sasaki, Noriomi Matsumura, Mikio Mikami, Toru Sugiyama
Objective: To examine the effectiveness of systemic chemotherapy following radical hysterectomy for women with intermediate-risk stage IB cervical cancer. Materials and Methods: This is a retrospective analysis of a previously organized nation-wide cohort study examining 6,003 women with stage IB-IIB cervical cancer who underwent radical hysterectomy between 2004 and 2008 in Japan. Survival of 555 women with stage IB cervical cancer in the intermediate-risk group (deep stromal invasion > 50%, large tumor size > 4 cm, and lympho-vascular space invasion [LVSI]) were examined based on adjuvant therapy patterns: chemotherapy alone (n = 223, 40...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290911/gastric-endoscopic-submucosal-dissection-as-a-treatment-for-early-neoplasia-and-for-accurate-staging-of-early-cancers-in-a-united-kingdom-caucasian-population
#4
Aisha Sooltangos, Matthew Davenport, Stephen McGrath, Jonathan Vickers, Siba Senapati, Kurshid Akhtar, Regi George, Yeng Ang
AIM: To investigate the efficacy of endoscopic submucosal dissection (ESD) at diagnosing and treating superficial neoplastic lesions of the stomach in a United Kingdom Caucasian population. METHODS: Data of patients treated with or considered for ESD at a tertiary referral center in the United Kingdom were retrieved for a period of 2 years (May 2015 to June 2017) from the electronic patient records of the hospital. Only Caucasian patients were included. Primary outcomes were curative resection (CR) and were defined as ESD resections with clear horizontal and vertical margin and an absence of lympho-vascular invasion, poor differentiation and submucosal involvement on histological evaluation of the resected specimen...
December 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29286516/cases-of-the-staff-unaccounted-exposure-during-the-construction-of-the-protective-shell-for-a-new-confinement-at-the-chnpp-site
#5
L K Bezdrobna, L V Tarasenko, T V Tsyganok, V A Kurochkina, V O Sushko, L I Shvayko
OBJECTIVE: cytogenetic control of the staff radiation exposure level during the construction of the protective shell for a new confinement at the ChNPP site. MATERIALS AND METHODS: A cytogenetic examination was carried out for 32 staff persons from the contracting organ izations involved into construction of the protective shell for a new confinement. Additionally, for the goal of com parison, 28 persons who did not have professional contacts with the radiation factors were inspected...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29285959/kyrle-s-disease-effectively-treated-with-oral-isotretinoin
#6
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
BACKGROUND: Kyrle's disease is a primary perforating dermatosis that affects more commonly 30-50 year old females, and clinically characterized by pruritic hyperkeratotic and ulcerated nodules, papules and plaques, localized on extensor surface of upper and lower limbs, and on the trunk. OBJECTIVE: To determine the effectiveness of the treatment with oral isotretinoin in Kyrle's disease. METHODS: We present the case of a 63-year-old woman with hyperkeratotic, erythematous-brown nodules and plaques localized on arms and legs, intensely itching; some lesions were ulcerated and discharging...
December 29, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29214365/profiling-differential-microrna-expression-between-in-situ-infiltrative-and-lympho-vascular-space-invasive-breast-cancer-a-pilot-study
#7
Patsy S Soon, Pamela J Provan, Edward Kim, Nirmala Pathmanathan, Dinny Graham, Christine L Clarke, Rosemary L Balleine
Ductal carcinoma in situ (DCIS), invasive breast cancer (IBC) and lympho-vascular invasion (LVI) represent distinct stages in breast cancer progression with different clinical implications. Altered microRNA (miRNA) expression may play a role in mediating the progression of DCIS to IBC and LVI. The aim of this pilot study was to investigate whether differential miRNA expression could play a role in breast cancer progression. Cancer cells from DCIS, IBC and LVI were microdissected from formalin fixed paraffin embedded (FFPE) tissue of five breast cancer samples...
December 6, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29185269/risk-stratification-models-for-para-aortic-lymph-node-metastasis-and-recurrence-in-stage-ib-iib-cervical-cancer
#8
Koji Matsuo, Muneaki Shimada, Tsuyoshi Saito, Kazuhiro Takehara, Hideki Tokunaga, Yoh Watanabe, Yukiharu Todo, Ken Ichirou Morishige, Mikio Mikami, Toru Sugiyama
OBJECTIVE: To examine the surgical-pathological predictors of para-aortic lymph node (PAN) metastasis at radical hysterectomy, and for PAN recurrence among women who did not undergo PAN dissection at radical hysterectomy. METHODS: This is a retrospective analysis of a nation-wide cohort study of surgically-treated stage IB-IIB cervical cancer (n=5,620). Multivariate models were used to identify independent surgical-pathological predictors for PAN metastasis/recurrence...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29170053/a-comparative-study-of-pathophysiological-alterations-in-scorpionism-induced-by-tityus-serrulatus-and-tityus-bahiensis-venoms
#9
Jackson G Miyamoto, Fabio B Andrade, Camila R Ferraz, Denise M Cândido, Irene Knysak, Émerson J Venâncio, Waldiceu A Verri, Maristella A Landgraf, Richardt G Landgraf, Fábio H Kwasniewski
Scorpionism is a relevant public health problem in several countries in tropical and subtropical regions. In Brazil, Tityus serrulatus sting can induce acute lung injury in part as a consequence of inflammation. Despite the occurrence of other scorpions of Tityus genus in Brazilian scorpiofauna, the knowledge regarding pulmonary alterations is related to T. serrulatus venom (Tsv). Here we studied, comparatively, the pathophysiological changes in the rat airways envenomed by Tsv or T. bahiensis venom (Tbv), since both scorpions are involved in human accidents but with severe envenomations occurring when victims are stung by T...
November 20, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29167569/single-cell-analysis-reveals-the-continuum-of-human-lympho-myeloid-progenitor-cells
#10
Dimitris Karamitros, Bilyana Stoilova, Zahra Aboukhalil, Fiona Hamey, Andreas Reinisch, Marina Samitsch, Lynn Quek, Georg Otto, Emmanouela Repapi, Jessica Doondeea, Batchimeg Usukhbayar, Julien Calvo, Stephen Taylor, Nicolas Goardon, Emmanuelle Six, Francoise Pflumio, Catherine Porcher, Ravindra Majeti, Berthold Göttgens, Paresh Vyas
The hierarchy of human hemopoietic progenitor cells that produce lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor populations produce lymphoid and myeloid cells, but they remain incompletely characterized. Here we demonstrated that lympho-myeloid progenitor populations in cord blood - lymphoid-primed multi-potential progenitors (LMPPs), granulocyte-macrophage progenitors (GMPs) and multi-lymphoid progenitors (MLPs) - were functionally and transcriptionally distinct and heterogeneous at the clonal level, with progenitors of many different functional potentials present...
November 21, 2017: Nature Immunology
https://www.readbyqxmd.com/read/29145251/renal-osteodystrophy-presenting-as-a-metabolic-superscan-on-f-18-fdg-pet-ct-a-case-report
#11
Ismaheel Lawal, Alfred Ankrah, Kehinde Ololade, Moshe Modiselle, Mike Sathekge
RATIONALE: F-18 Fluoro Deoxyglucose positron emission tomography and computed tomography (F-18 FDG PET/CT) is a useful modality in the evaluation of patients with malignancies. Increased incidence of lympho-proliferative disorders has been reported in individuals with long-standing end-stage renal disorders treated with renal replacement therapy. PATIENT CONCERNS: A 30-year-old male on peritoneal dialysis on account of end-stage renal disease. He had acute rejection of an earlier transplanted renal allograft...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29113861/identification-and-characterization-of-myeloperoxidase-in-orange-spotted-grouper-epinephelus-coioides
#12
Hai-Qing Wang, Ling Zhou, Man Yang, Xiao-Chun Luo, Yan-Wei Li, Xue-Ming Dan
Cryptocaryon irritans is an important protozoan ciliate, which has led to heavy economic losses in marine aquaculture. Previous studies have indicated that C. irritans infection could induce the migration of neutrophils to infection sites. Myeloperoxidase (MPO) mainly exists in the cytoplasmic granules of the neutrophil and performs its function by a unique enzymatic capacity to produce hypohalous acid and other toxic oxidants. To determine the involvement of MPO and neutrophils against C. irritans infection in the host, we amplified MPO cDNA (EcMPO) from orange-spotted grouper (Epinephelus coioides)...
November 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29112018/tumor-budding-and-pdc-grade-are-stage-independent-predictors-of-clinical-outcome-in-mismatch-repair-deficient-colorectal-cancer
#13
Éanna Ryan, Yi Ling Khaw, Ben Creavin, Robert Geraghty, Elizabeth J Ryan, David Gibbons, Ann Hanly, Sean T Martin, P Ronan O'Connell, Desmond C Winter, Kieran Sheahan
Mismatch repair deficient (dMMR) colorectal cancer (CRC) despite its association with poor histologic grade often has improved prognosis compared with MMR proficient CRC. Tumor budding and poorly differentiated clusters (PDCs) may predict metastatic potential of colorectal adenocarcinoma (CRC). In addition, their assessment may be more reproducible than the evaluation of other histopathologic parameters. Therefore, we wished to determine their potential as prognostic indicators in a cohort of dMMR CRC patients relative to histologic grade...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29073846/the-incidence-of-non-melanoma-skin-cancer-and-post-transplant-lympho-proliferative-disorders-in-the-scottish-cardiac-transplant-population-and-the-provision-of-specialist-dermatological-follow-up
#14
Iain McPherson, Alan Kirk
Background Immunosuppression helps prevent acute rejection post-cardiac transplant but has been linked to malignancy development. This may be due to a reduction in T-lymphocyte function, a direct oncogenic effect or the increased impact of environmental carcinogens. There has been shown to be significant increases in non-melanoma skin cancers and post-transplant lympho-proliferative disorders, particularly in those treated with OKT3. Aim To investigate the survival and incidence of malignancy in the Scottish cardiac transplant population and whether rates of non-melanoma skin cancers justify the provision of specialist dermatological follow-up...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/29057508/impact-of-antiviral-prophylaxis-in-adults-ebv-seronegative-kidney-recipients-on-early-and-late-ptld-onset-a-retrospective-cohort-study
#15
Simon Ville, Berthe-Marie Imbert-Marcille, Marianne Coste-Burel, Claire Garandeau, Aurélie Meurette, Diego Cantarovitch, Magali Giral, Maryvonne Hourmant, Gilles Blancho, Jacques Dantal
Post-transplantation lympho-proliferative disorder (PTLD) pathogenesis is related to EBV infection. Mismatch with the donor (EBV D+/R-) is the main risk factor for both early PTLD (< 1 year post transplantation) and late (> 1 year). In these at-risk patients, the role of antiviral prophylaxis for preventing PTLD remains controversial. We analysed the impact of antiviral drugs given to prevent CMV disease in a mono-centric retrospective cohort of 73 adult kidney or kidney-pancreas EBV seronegative recipients, transplanted between 01/01/2000 and 01/01/2016...
October 23, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29055921/hepatitis-c-and-its-metabolic-complications-in-kidney-disease
#16
Fabrizio Fabrizi, Francesca M Donato, Piergiorgio Messa
INTRODUCTION: Evidence has been accumulated during the last decade showing that HCV infection plays an important activity at hepatic and extra-hepatic level. Chronic HCV is associated with a large spectrum of extra-hepatic manifestations including lympho-proliferative diseases and metabolic abnormalities (such as insulin resistance and fatty liver disease). MATERIAL AND METHODS: We have performed an extensive review of the medical literature regarding the increased risk of cardiovascular and kidney disease that has been observed in various groups of HCV-infected patients...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29050516/human-bone-marrow-mesenchymal-stromal-cell-derived-osteoblasts-promote-the-expansion-of-hematopoietic-progenitors-through-beta-catenin-and-notch-signaling-pathways
#17
Matthew Michalicka, Gavin Boisjoli, Suria Jahan, Owen Hovey, Emily Doxtator, Ahmad Abu-Khader, Roya Pasha, Nicolas Pineault
Coculture of hematopoietic stem cells (HSC) with primary stromal cells from HSC niches supports the maintenance and expansion of HSC and progenitors ex vivo. However, a major drawback is the availability of primary human samples for research and clinical applications. We investigated the use of in vitro derived osteoblasts as a new source of feeder cells and characterized the molecular pathways that mediate their growth promoting activities. First, we compared the growth and differentiation modulating activities of mesenchymal stromal cells (MSC)-derived osteoblasts (M-OST) to that of their undifferentiated precursor on umbilical cord blood (UCB) progenitors...
October 19, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29045900/molecular-and-functional-characterization-of-lymphoid-progenitor-subsets-reveals-a-bipartite-architecture-of-human-lymphopoiesis
#18
Kutaiba Alhaj Hussen, Thien-Phong Vu Manh, Fabien Guimiot, Elisabeth Nelson, Emna Chabaane, Marc Delord, Maxime Barbier, Claire Berthault, Nicolas Dulphy, Antonio José Alberdi, Odile Burlen-Defranoux, Gerard Socié, Jean Christophe Bories, Jerôme Larghero, Valérie Vanneaux, Els Verhoeyen, Thierry Wirth, Marc Dalod, Jean Claude Gluckman, Ana Cumano, Bruno Canque
The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127(-) and CD127(+) early lymphoid progenitors (ELPs). Combining molecular analyses with in vitro and in vivo functional assays, we demonstrated that CD127(-) and CD127(+) ELPs emerged independently from lympho-mono-dendritic progenitors, responded differently to Notch1 signals, underwent divergent modes of lineage restriction, and displayed both common and specific differentiation potentials...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29033421/the-resolution-of-helicobacter-suis-associated-gastric-lesions-after-eradication-therapy
#19
Satoru Nakagawa, Tadashi Shimoyama, Masahiko Nakamura, Daisuke Chiba, Hidezumi Kikuchi, Manabu Sawaya, Daisuke Chinda, Tatsuya Mikami, Shinsaku Fukuda
A reddish depressed lesion was found in the corpus of the stomach of a 56-year-old man. Gastric biopsy showed no findings of MALT lymphoma, including lympho-epithelial lesions. A urea breath test, stool antigen test and serum IgG antibody to Helicobacter pylori test were negative. Magnifying endoscopy using narrow-band-imaging showed no malignant structures. Gastric biopsy specimens were subjected to immunohistochemistry and a PCR, which identified Helicobacter suis infection. Triple therapy with esomeprazole, metronidazole, and amoxicillin was administered for 10 days...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29030486/single-cell-rna-sequencing-reveals-developmental-heterogeneity-among-early-lymphoid-progenitors
#20
Llucia Alberti-Servera, Lilly von Muenchow, Panagiotis Tsapogas, Giuseppina Capoferri, Katja Eschbach, Christian Beisel, Rhodri Ceredig, Robert Ivanek, Antonius Rolink
Single-cell RNA sequencing is a powerful technology for assessing heterogeneity within defined cell populations. Here, we describe the heterogeneity of a B220(+)CD117(int)CD19(-)NK1.1(-) uncommitted hematopoietic progenitor having combined lymphoid and myeloid potential. Phenotypic and functional assays revealed four subpopulations within the progenitor with distinct lineage developmental potentials. Among them, the Ly6D(+)SiglecH(-)CD11c(-) fraction was lymphoid-restricted exhibiting strong B-cell potential, whereas the Ly6D(-)SiglecH(-)CD11c(-) fraction showed mixed lympho-myeloid potential...
October 13, 2017: EMBO Journal
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