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https://www.readbyqxmd.com/read/28512646/mri-in-glioma-immunotherapy-evidence-pitfalls-and-perspectives
#1
REVIEW
Domenico Aquino, Andrea Gioppo, Gaetano Finocchiaro, Maria Grazia Bruzzone, Valeria Cuccarini
Pseudophenomena, that is, imaging alterations due to therapy rather than tumor evolution, have an important impact on the management of glioma patients and the results of clinical trials. RANO (response assessment in neurooncology) criteria, including conventional MRI (cMRI), addressed the issues of pseudoprogression after radiotherapy and concomitant chemotherapy and pseudoresponse during antiangiogenic therapy of glioblastomas (GBM) and other gliomas. The development of cancer immunotherapy forced the identification of further relevant response criteria, summarized by the iRANO working group in 2015...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28484400/steroid-responsive-chronic-schizophreniform-syndrome-in-the-context-of-mildly-increased-antithyroid-peroxidase-antibodies
#2
Dominique Endres, Evgeniy Perlov, Anne Nicole Riering, Viktoria Maier, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Ludger Tebartz van Elst
BACKGROUND: Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with increased thyroid antibodies, such as antithyroid peroxidase antibodies and shows a good response to corticosteroids. CASE PRESENTATION: We present the case of a 41-year-old woman suffering from a schizophreniform syndrome...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28474187/idh-mutant-and-1p-19q-co-deleted-oligodendrogliomas-tumor-grade-stratification-using-diffusion-susceptibility-and-perfusion-weighted-mri
#3
Yu Lin, Zhen Xing, Dejun She, Xiefeng Yang, Yingyan Zheng, Zebin Xiao, Xingfu Wang, Dairong Cao
PURPOSE: Currently, isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion are proven diagnostic biomarkers for both grade II and III oligodendrogliomas (ODs). Non-invasive diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) are widely used to provide physiological information (cellularity, hemorrhage, calcifications, and angiogenesis) of neoplastic histology and tumor grade. However, it is unclear whether DWI, SWI, and DSC-PWI are able to stratify grades of IDH-mutant and 1p/19q co-deleted ODs...
May 4, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28465287/prevalence-of-subclinical-coronary-artery-disease-in-masters-endurance-athletes-with-a-low-atherosclerotic-risk-profile
#4
Ahmed Merghani, Viviana Maestrini, Stefania Rosmini, Andrew T Cox, Harshil Dhutia, Rachel Bastiaenen, Sarojini David, Tee Joo Yeo, Rajay Narain, Aneil Malhotra, Michael Papadakis, Mathew G Wilson, Maite Tome, Khaled AlFakih, James C Moon, Sanjay Sharma
Background -Studies in middle aged and older (masters) athletes with atherosclerotic risk factors for coronary artery disease (CAD) report higher coronary artery calcium (CAC) scores compared with sedentary individuals. Few studies have assessed the prevalence of CAD in masters athletes with a low atherosclerotic risk profile. Methods -We assessed 152 masters athletes aged 54.4±8.5 years (70% male) and 92 controls of similar age, sex and low Framingham 10 year CAD risk scores with an echocardiogram, exercise stress test, CT coronary angiogram, and cardiovascular magnetic resonance imaging (CMRI) with late gadolinium enhancement (LGE) and a 24-hour Holter...
May 2, 2017: Circulation
https://www.readbyqxmd.com/read/28452619/comparison-of-mri-techniques-for-detecting-microadenomas-in-cushing-s-disease
#5
Yuval Grober, Hagit Grober, Max Wintermark, John A Jane, Edward H Oldfield
OBJECTIVE Many centers use conventional and dynamic contrast-enhanced MRI (DMRI) sequences in patients with Cushing's disease. The authors assessed the utility of the 3D volumetric interpolated breath-hold examination, a spoiled-gradient echo 3D T1 sequence (SGE) characterized by superior soft tissue contrast and improved resolution, compared with DMRI and conventional MRI (CMRI) for detecting microadenomas in patients with Cushing's disease. METHODS This study was a blinded assessment of pituitary MRI in patients with proven Cushing's disease...
April 28, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28451954/incidental-findings-in-cardiac-magnetic-resonance-imaging-superiority-of-bssfp-over-t1w-haste-for-extra-cardiac-findings-assessment
#6
Jan M Sohns, Jan Menke, Alexander Schwarz, Leonard Bergau, Johannes T Kowallick, Andreas Schuster, Frank Konietschke, Marius Placzek, Desiree Weiberg, Stefan Nordlohne, Sebastian Schmuck, Sebastian Schulz, Thorsten Derlin, Wieland Staab
Incidental findings are frequent in radiological examinations and may have an impact on further patient management. The aim of this retrospective study was to analyze, which of two thoracic scout sequences is more suitable for detecting incidental extra-cardiac findings at cardiac magnetic resonance imaging (CMRI) with stress perfusion. During a 14-month period clinically indicated stress perfusion CMRI was performed in 97 consecutive patients. For anatomical orientation ECG-triggered (electrocardiography) T1w-Half-fourier acquisition single-shot turbo spin-echo (HASTE) and balanced steady state free precession (bSSFP) sequences were performed for planning the standard cardiac sequences...
April 27, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28439937/maternal-nutrient-restriction-during-pregnancy-and-lactation-leads-to-impaired-right-ventricular-function-in-young-adult-baboons
#7
Anderson H Kuo, Cun Li, Hillary F Huber, Matthias Schwab, Peter W Nathanielsz, Geoffrey D Clarke
KEY POINTS: Maternal nutrient restriction induces intrauterine growth restriction (IUGR) and leads to heightened cardiovascular risks later in life. We report right ventricular (RV) filling and ejection abnormalities in IUGR young adult baboons using cardiac magnetic resonance imaging. Both functional and morphological indicators of poor RV function were seen, many of which were similar to effects of ageing, but also with a few key differences. We observed more pronounced RV changes compared to our previous report of the left ventricle, suggesting there is likely to be a component of isolated RV abnormality in addition to expected haemodynamic sequelae from left ventricular dysfunction...
April 25, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28434954/coronal-multiplane-reconstructed-ct-image-determining-lateral-vertebral-notch-referred-pedicle-screw-entry-point-in-subaxial-cervical-spine-a-preclinical-study
#8
Chunyang Wu, Zhongren Huang, Zhimin Pan, Jiaquan Luo, Zhiyun Li, Junlong Zhong, Yiwei Chen, Zhimin Han, Kuniyoshi Abumi, Yoon Ha, Kai Cao
OBJECTIVE: Evaluate the feasibility of coronal multiplane reconstruction images (CMRI) of CT scan to determine subaxial cervical pedicle screw (PS) entry point and guide lateral vertebral notch (LVN)-referred technique for subaxial cervical PS insertion. METHODS: Forty cervical CT scans from volunteers were performed. Entry point of PS was determined through quantitating the PS entry point related to LVN on CMRI. Pedicle mediolateral angle (α) and cephalocaudad angle (β) were also measured to guide trajactory of PS insertion...
April 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28339663/cardiac-involvement-in-granulomatosis-with-polyangiitis-a-magnetic-resonance-imaging-study-of-31-consecutive-patients
#9
Grégory Pugnet, Hervé Gouya, Xavier Puéchal, Benjamin Terrier, André Kahan, Paul Legmann, Loïc Guillevin, Olivier Vignaux
Objectives.: Specific cardiac involvement in granulomatosis with polyangiitis (GPA) is probably underestimated since many of these conditions are subclinical. The objective of this study was to assess the prevalence and patterns of cardiac abnormalities detected by cardiac MRI (CMRI) in patients with GPA. Methods.: Thirty-one consecutive patients with newly diagnosed or relapsing GPA underwent CMRI to assess morphological, functional, perfusion at rest and delayed enhancement abnormalities...
February 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28268538/a-unified-bayesian-based-compensated-magnetic-resonance-imaging
#10
Ameneh Boroomand, Edward Li, Mohammad Javad Shafiee, Masoom A Haider, Farzad Khalvati, Alexander Wong
Magnetic resonance (MR) images of higher quality is demanded for helping with more accurate and earlier diagnosis of different diseases. The overall quality of MR images is limited due to the existence of different degradation factors such as (1) MR aberrations due to intrinsic properties of the MR scanner, (2) magnetic field inhomogeneity, and (3) inherent MRI noise. Correcting each MRI degradation factor could be solely useful for the quality enhancement of MR imaging with a limited impact. Here, we propose a unified Bayesian based compensated MR imaging (CMRI) system which jointly corrects for the different aforementioned MR aberrations as well as MR noise and hence generates compensated MR (CMR) images with a higher quality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267213/echocardiography-fails-to-detect-left-ventricular-noncompaction-in-a-cohort-of-patients-with-noncompaction-on-cardiac-magnetic-resonance-imaging
#11
Sachin Diwadkar, Leelakrishna Nallamshetty, Carlos Rojas, Alexia Athienitis, Chris Declue, Chad Cox, Aarti Patel, Sanders H Chae
BACKGROUND: Left ventricular noncompaction (LVNC) is a rare disorder characterized by increased left ventricular trabeculation, deep intertrabecular recesses, and a thin compacted myocardial layer with associated clinical sequelae. Cardiac imaging with echocardiogram and cardiac magnetic resonance (CMRI) can detect variable myocardial morphology including excessive trabeculations. Multiple CMRI and echocardiographic criteria have been offered that attempt to identify LVNC morphology. The aim of this study was to assess the utility of echocardiogram in identifying LVNC in a cohort of patients with LVNC detected on CMRI...
March 7, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28236185/the-accuracy-of-the-lateral-vertebral-notch-referred-pedicle-screw-insertion-technique-in-subaxial-cervical-spine-a-human-cadaver-study
#12
Jiaquan Luo, Chunyang Wu, Zhongren Huang, Zhimin Pan, Zhiyun Li, Junlong Zhong, Yiwei Chen, Zhimin Han, Kai Cao
STUDY DESIGN: This is a cadaver specimen study to confirm new pedicle screw (PS) entry point and trajectory for subaxial cervical PS insertion. OBJECTIVE: To assess the accuracy of the lateral vertebral notch-referred PS insertion technique in subaxial cervical spine in cadaver cervical spine. BACKGROUNDS: Reported morphometric landmarks used to guide the surgeon in PS insertion show significant variability. In the previous study, we proposed a new technique (as called "notch-referred" technique) primarily based on coronal multiplane reconstruction images (CMRI) and cortical integrity after PS insertion in cadavers...
February 24, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28226714/a-unified-bayesian-based-compensated-magnetic-resonance-imaging
#13
Ameneh Boroomand, Edward Li, Mohammad Javad Shafiee, Masoom A Haider, Farzad Khalvati, Alexander Wong, Ameneh Boroomand, Edward Li, Mohammad Javad Shafiee, Masoom A Haider, Farzad Khalvati, Alexander Wong, Alexander Wong, Mohammad Javad Shafiee, Edward Li, Masoom A Haider, Ameneh Boroomand, Farzad Khalvati
Magnetic resonance (MR) images of higher quality is demanded for helping with more accurate and earlier diagnosis of different diseases. The overall quality of MR images is limited due to the existence of different degradation factors such as (1) MR aberrations due to intrinsic properties of the MR scanner, (2) magnetic field inhomogeneity, and (3) inherent MRI noise. Correcting each MRI degradation factor could be solely useful for the quality enhancement of MR imaging with a limited impact. Here, we propose a unified Bayesian based compensated MR imaging (CMRI) system which jointly corrects for the different aforementioned MR aberrations as well as MR noise and hence generates compensated MR (CMR) images with a higher quality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219755/a-congenital-diverticulum-of-the-left-ventricular-apex-manifested-by-stroke-and-recurrent-ventricular-tachycardia
#14
Gabriela Dostálová, Tomáš Paleček, Petr Kuchynka, Štěpán Havránek, Martin Mašek, Zuzana Hlubocká, Debora Karetová, Dan Wichterle, Jaroslava Dušková, Jaroslav Lindner, Aleš Linhart
Ventricular outpouchings include acquired abnormalities (aneurysms and pseudoaneurysms) and congenital ventricular diverticula (CVD). CVD represent rare cardiac pathologies. Although CVD is often associated with other cardiac and extracardiac congenital anomalies, it can also be incidentally observed in otherwise healthy subjects. CVD may lead to significant morbidity and even have lethal consequences. We describe a case of arrhythmogenic left ventricle (LV) apical CVD revealed by cardiac magnetic resonance imaging (CMRI) after being initially overlooked by echocardiography...
May 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28209142/accuracy-of-magnetic-resonance-studies-in-the-detection-of-chondral-and-labral-lesions-in-femoroacetabular-impingement-systematic-review-and-meta-analysis
#15
A M Saied, C Redant, M El-Batouty, M R El-Lakkany, W A El-Adl, J Anthonissen, R Verdonk, E A Audenaert
BACKGROUND: Several types of Magnetic resonance imaging (MRI) are commonly used in imaging of femoroacetabular impingement (FAI), however till now there are no clear protocols and recommendations for each type. The aim of this meta-analysis is to detect the accuracy of conventional magnetic resonance imaging (cMRI), direct magnetic resonance arthrography (dMRA) and indirect magnetic resonance arthrography (iMRA) in the diagnosis of chondral and labral lesions in femoroacetabular impingement (FAI)...
February 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28150010/-acute-vestibular-syndrome-following-cerebellar-stroke-case-report-and-literature-review-german-version
#16
V Volgger, R Gürkov
The current paper reports on a patient with recurrent rotational vertigo and persistent dizziness and imbalance lasting weeks, who underwent extensive neurootological and radiological examination. Pathological findings initially included right-sided benign paroxysmal positional vertigo (BPPV), persistent horizontal spontaneous nystagmus (SPN) to the left and a pathological bedside and video head impulse test (HIT) on the left. The pathological HIT on the left and SPN to the left indicated a central genesis...
February 1, 2017: HNO
https://www.readbyqxmd.com/read/28107664/safety-and-efficacy-of-cardiopoietic-stem-cells-in-the-treatment-of-post-infarction-left-ventricular-dysfunction-from-cardioprotection-to-functional-repair-in-a-translational-pig-infarction-model
#17
Maximilian Y Emmert, Petra Wolint, Andras Jakab, Sean P Sheehy, Francesco S Pasqualini, Thi Dan Linh Nguyen, Monika Hilbe, Burkhardt Seifert, Benedikt Weber, Chad E Brokopp, Dominika Macejovska, Etem Caliskan, Arnold von Eckardstein, Ruth Schwartlander, Viola Vogel, Volkmar Falk, Kevin Kit Parker, Mariann Gyöngyösi, Simon P Hoerstrup
To date, clinical success of cardiac cell-therapies remains limited. To enhance the cardioreparative properties of stem cells, the concept of lineage-specification through cardiopoietic-guidance has been recently suggested. However, so far, only results from murine studies and from a clinical pilot-trial in chronic heart-failure (CHF) are available, while systematic evidence of its therapeutic-efficacy is still lacking. Importantly, also no data from large animals or for other indications are available. Therefore, we here investigate the therapeutic-efficacy of human cardiopoietic stem cells in the treatment of post-infarction LV-dysfunction using a translational pig-model...
April 2017: Biomaterials
https://www.readbyqxmd.com/read/28081214/cold-pressor-stress-cardiac-magnetic-resonance-myocardial-flow-reserve-is-not-useful-for-detection-of-coronary-endothelial-dysfunction-in-women-with-signs-and-symptoms-of-ischemia-and-no-obstructive-cad
#18
Sofy Landes, Sherwin Dela Cruz, Janet Wei, Ahmed AlBadri, Chrisandra Shufelt, Puja Mehta, Louise E Thomson, Marcio A Diniz, Xiao Zhang, John W Petersen, R David Anderson, Carl J Pepine, Daniel S Berman, C Noel Bairey Merz
BACKGROUND: Coronary endothelial function testing using acetylcholine is not routinely available, while non-pharmacological cold pressor testing (CPT) is considered an endothelial stressor. Noninvasive cardiac magnetic resonance imaging (CMRI) myocardial perfusion reserve index (MPRI) can detect coronary microvascular dysfunction (CMD). We evaluated if CPT stress CMRI MPRI could detect invasive coronary endothelial dysfunction. METHODS: Coronary reactivity testing was performed in 189 women with symptoms and signs of ischemic but no obstructive coronary artery disease as previously described plus CPT stress...
2017: PloS One
https://www.readbyqxmd.com/read/28065824/variable-white-matter-atrophy-and-intellectual-development-in-a-family-with-x-linked-creatine-transporter-deficiency-despite-genotypic-homogeneity
#19
Nicole Heussinger, Marc Saake, Angelika Mennecke, Helmuth-Günther Dörr, Regina Trollmann
BACKGROUND: The X-linked creatine transporter deficiency (CRTD) caused by an SLC6A8 mutation represents the second most common cause of X-linked intellectual disability. The clinical phenotype ranges from mild to severe intellectual disability, epilepsy, short stature, poor language skills, and autism spectrum disorders. The objective of this study was to investigate phenotypic variability in the context of genotype, cerebral creatine concentration, and volumetric analysis in a family with CRTD...
October 17, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/28026027/the-contemporary-value-of-peak-creatine-kinase-mb-after-st-segment-elevation-myocardial-infarction-above-other-clinical-and-angiographic-characteristics-in-predicting-infarct-size-left-ventricular-ejection-fraction-and-mortality
#20
Minke H T Hartman, Ruben N Eppinga, Pieter J J Vlaar, Chris P H Lexis, Erik Lipsic, Joost D E Haeck, Dirk J van Veldhuisen, Iwan C C van der Horst, Pim van der Harst
BACKGROUND: Complex multimarker approaches to predict outcome after ST-elevation myocardial infarction (STEMI) have only considered a single baseline sample, while neglecting easily obtainable peak creatine kinase and creatine kinase-MB (CK-MB) values during hospitalization. METHODS: We studied 476 patients undergoing primary percutaneous coronary intervention for STEMI and cardiac magnetic resonance imaging (CMRI) at 4-6 months after STEMI. We determined the association with cardiac biomarkers (peak CK-MB, peak troponin T, N-terminal pro-brain natriuretic peptide), clinical and angiographic characteristics with infarct size, and LVEF, followed by association with mortality in 1120 STEMI patients...
December 27, 2016: Clinical Cardiology
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