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https://www.readbyqxmd.com/read/27924218/sex-related-differences-in-the-associations-between-plasma-free-fatty-acid-levels-and-clinical-features-in-patients-with-hypertrophic-cardiomyopathy
#1
Chengzhi Yang, Changlin Zhang, Jiansong Yuan, Jingang Cui, Shengwen Liu, Fenghuan Hu, Weixian Yang, Xuanye Bi, Shubin Qiao
BACKGROUND: Previous studies have indicated that inefficient energy utilization may play a pivotal role in hypertrophic cardiomyopathy (HCM). However, whether plasma free fatty acid (FFA), a main energy substrate of heart, has an effect on HCM remains unclear. Besides, several studies have suggested sex-related differences in HCM features and FFA metabolism. Here, we aimed to explore the association between plasma FFA levels and HCM and potential effects of sex on this relation. METHODS: A total of 412 patients (age 47...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27895877/unexplained-cardiac-arrest-after-near-drowning-in-a-young-experienced-swimmer-insight-from-cardiovascular-magnetic-resonance-imaging
#2
Cesare Mantini, Giancarlo Messalli, Leonardo Paloscia, Domenico Mastrodicasa, Marco Francone, Marco Mascellanti, Alberto D'Alleva, Antonio Raffaele Cotroneo
Cardiac magnetic resonance imaging (cMRI) is a well-established noninvasive imaging modality in clinical cardiology. Its ability to provide tissue characterization make it well suited for the study of patients with cardiac diseases. We describe a multi-modality imaging evaluation of a 45-year-old man who experienced a near drowning event during swimming. We underline the unique capability of tissue characterization provided by cMRI, which allowed detection of subtle, clinically unrecognizable myocardial damage for understanding the causes of sudden cardiac arrest and also showed the small damages caused by cardiopulmonary resuscitation...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27866381/cardiac-magnetic-resonance-imaging-of-patent-ductus-arteriosus-in-three-dogs
#3
Youngjae Lee, Jaihyun Jung, Junyong Park, Jiyoon Jeong, Seokho Jeon, Sunyoung Park, Jinhwa Chang, Ji-Houn Kang, Chulhyun Lee, Dongwoo Chang
Patent ductus arteriosus (PDA) is the most common congenital cardiovascular disorder in dogs and requires an accurate diagnosis for an appropriate treatment. Cardiac MRI (cMRI) has been reported as a method for characterization of canine thoracic vasculature. However, to the authors' knowledge, no published studies describe evaluation of canine PDA through cMRI. Three dogs were selected for this exploratory study. Electrocardiogram gating and breath-hold techniques were performed using a 3T MR scanner. Both black blood imaging and bright blood cine acquisitions were performed...
November 20, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27812502/comparison-of-unsupervised-classification-methods-for-brain-tumor-segmentation-using-multi-parametric-mri
#4
N Sauwen, M Acou, S Van Cauter, D M Sima, J Veraart, F Maes, U Himmelreich, E Achten, S Van Huffel
Tumor segmentation is a particularly challenging task in high-grade gliomas (HGGs), as they are among the most heterogeneous tumors in oncology. An accurate delineation of the lesion and its main subcomponents contributes to optimal treatment planning, prognosis and follow-up. Conventional MRI (cMRI) is the imaging modality of choice for manual segmentation, and is also considered in the vast majority of automated segmentation studies. Advanced MRI modalities such as perfusion-weighted imaging (PWI), diffusion-weighted imaging (DWI) and magnetic resonance spectroscopic imaging (MRSI) have already shown their added value in tumor tissue characterization, hence there have been recent suggestions of combining different MRI modalities into a multi-parametric MRI (MP-MRI) approach for brain tumor segmentation...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27787806/acyclovir-resistance-in-herpes-simplex-virus-type-i-encephalitis-a-case-report
#5
M Bergmann, R Beer, M Kofler, R Helbok, B Pfausler, E Schmutzhard
Acyclovir resistance is rarely seen in herpes simplex virus (HSV) type I encephalitis. Prevalence rates vary between 0.5 % in immunocompetent patients (Christophers et al. 1998; Fife et al. 1994) and 3.5-10 % in immunocompromised patients (Stranska et al. 2005). We report a 45-year-old, immunocompetent (negative HIV antigen/antibody testing), female patient, without previous illness who developed-after a febrile prodromal stage-aphasia and psychomotor slowing. Cerebral magnetic resonance imaging (cMRI) showed right temporal and insular T2-hyperintense lesions with spreading to the contralateral temporal lobe...
October 27, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27747166/right-ventricular-failure-predicted-from-right-bundle-branch-block-cardiac-magnetic-resonance-imaging-validation
#6
Santhosh R Devarapally, Sameer Arora, Ali Ahmad, Mike Sood, Amaar El Sergany, Terrence Sacchi, Barry Saul, Rahul Gaglani, John Heitner
BACKGROUND: Right ventricular (RV) failure has proven to be independently associated with adverse outcomes. Electrocardiographic parameters assessing RV function are largely unknown, making echocardiography the first line for RV function assessment. It is however, limited by geometrical assumptions and is inferior to cardiac magnetic resonance imaging (CMRI) which is widely regarded as the most accurate tool for assessing RV function. METHODS: We seek to determine the correlation of ECG parameters of right bundle branch block (RBBB) with RV ejection fraction (EF) and RV dimensions using the CMRI...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27667381/the-role-of-cardiac-magnetic-resonance-imaging-in-hypertrophic-cardiomyopathy
#7
Marco Marchesini, Lucia Uguccioni, Rosario Parisi, Gianmaria Mattioli, Francesca Terzi, Roberto Olivieri, Alessandro Capucci, Rossella Fattori
Until recently, the only imaging technique for the diagnosis and management of hypertrophic cardiomyopathy (HCM) was two-dimensional echocardiography, and the use of cardiac magnetic resonance imaging (cMRI) was limited to patients with poor acoustic windows. Now, cMRI has gained an essential role in the diagnosis of HCM, providing superior visualization of myocardial hypertrophy-even in remote zones of the left ventricle-and visualization of subtle changes in thickness and contractility over time. The morphologic accuracy of cMRI allows for the differentiation of HCM from other pathologic conditions with hypertrophic phenotype...
2016: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27566477/prolonged-qt-and-myocardium-recovery-after-primary-pci-a-cmri-study
#8
Riccardo Ieva, Graziapia Casavecchia, Matteo Gravina, Antonio Totaro, Armando Ferraretti, Luca Macarini, Matteo Di Biase, Natale Daniele Brunetti
BACKGROUND: The presence of viable stunned myocardium recovering after primary angioplasty is not easy to identify in the early phase of acute myocardial infarction (AMI) by noninvasive bed-side methods. We therefore aimed to assess whether a simple electrocardiogram parameter may be of help in identifying the presence of stunned viable myocardium recovering after reperfusion with primary angioplasty. MATERIALS AND METHODS: A total of 14 consecutive patients with ST-elevation AMI (STEMI) were enrolled in the study and underwent QT duration assessment after admission: the difference between QT corrected (QTc) in the ischaemic areas and QTc values in nonischaemic areas was therefore calculated and compared with the presence and the extension of viable stunned myocardium, assessed by comparing akinetic/dyskinetic areas at admission echocardiography with akinetic/dyskinetic areas and extension of scar at 6-month cardiac magnetic resonance imaging (cMRI)...
October 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27500951/left-ventricular-vascular-and-metabolic-adaptations-to-high-intensity-interval-and-moderate-intensity-continuous-training-a-randomized-trial-in-healthy-middle-aged-men
#9
Jari-Joonas Eskelinen, Ilkka Heinonen, Eliisa Löyttyniemi, Juuso Hakala, Marja A Heiskanen, Kumail K Motiani, Kirsi Virtanen, Jussi P Pärkkä, Juhani Knuuti, Jarna C Hannukainen, Kari K Kalliokoski
KEY POINTS: High-intensity interval training (HIIT) has become popular, time-sparing alternative to moderate intensity continuous training (MICT), although the cardiac vascular and metabolic effects of HIIT are incompletely known. We compared the effects of 2-week interventions with HIIT and MICT on myocardial perfusion and free fatty acid and glucose uptake. Insulin-stimulated myocardial glucose uptake was decreased by training without any significantly different response between the groups, whereas free fatty acid uptake remained unchanged...
December 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27499522/changes-in-gene-expression-profiles-in-patients-with-pulmonary-arterial-hypertension-associated-with-scleroderma-treated-with-tadalafil
#10
Fei-Ying Cheong, Adam C Gower, Harrison W Farber
OBJECTIVE: Pulmonary arterial hypertension (PAH) is one of the most devastating complications in scleroderma (SSc) patients and has a poorer outcome than other PAH subgroups. Tadalafil (Adcirca(®)) is a phosphodiesterase-5 inhibitor (PDE5-I) approved by the FDA for treatment of PAH; however, its effectiveness specifically in SSc-PAH patients is unclear. We investigated whether there were differences in gene expression associated with 16 weeks of treatment with tadalafil and, if so, whether these changes differed with respect to treatment outcome...
June 7, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27495050/early-diagnosis-and-follow-up-of-chronic-active-epstein-barr-virus-associated-cardiovascular-complications-with-cardiovascular-magnetic-resonance-imaging-a-case-report
#11
Shu Jiang, Xiao Li, Jian Cao, Di Wu, Lingyan Kong, Lu Lin, Zhengyu Jin, Jing An, Yining Wang
INTRODUCTION: Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is characterized as chronic or recurrent mononucleosis-like symptoms and elevated EBV deoxyribonucleic acid (EBV-DNA) copies. Cardiovascular complications have high morbidity and mortality. The treatment regimen for CAEBV has not been established yet, resulting in poor prognoses. Herein, we present a case of cardiovascular magnetic resonance imaging (CMRI) evaluation with a series of sequences for CAEBV-associated cardiovascular involvement, which has never been reported...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27494731/no-evidence-of-adverse-cardiac-remodeling-in-former-elite-endurance-athletes
#12
Fabian Sanchis-Gomar, Marta López-Ramón, Rafael Alis, Nuria Garatachea, Helios Pareja-Galeano, Alejandro Santos-Lozano, Pilar Catalán, Veronica Sansoni, Silvia Perego, Giovanni Lombardi, Herbert Löllgen, Hector Bueno, Enrique Serrano-Ostáriz, Alejandro Lucia
BACKGROUND: The impact of high exercise loads on a previously healthy heart remains controversial. We examined the consequences of decades of strenuous endurance exercise at the highest competition level on heart dimensions and volumes as well as on serum biomarkers of cardiac fibrosis/remodeling. METHODS AND RESULTS: We compared echocardiographic measurements and serum biomarkers of cardiac fibrosis/remodeling [troponin I, galectin-3, matrix metallopeptidase-2 and -9, N-terminal pro-brain natriuretic peptide, carboxy-terminal propeptide of type I procollagen, and soluble suppressor of tumorigenicity-2 (sST-2)/interleukin(IL)-1R4] in 53 male athletes [11 former professional ('elite') and 42 amateur-level ('sub-elite') cyclists or runners, aged 40-70years] and 18 aged-matched controls...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27466544/the-value-of-endorectal-magnetic-resonance-imaging-of-the-prostate-in-improving-the-detection-of-anterior-prostate-cancer
#13
Vahudin Zugor, Reinhard Kühn, Karl Engelhard, Sandor Poth, Marija Maja Bernat, Daniel Porres, Apostolos P Labanaris
BACKGROUND/AIM: The diagnosis of anterior prostate cancer (APC) is troublesome due to its anatomical location. Patients with an APC often require multiple sets of biopsies until diagnosis is made. The objective of this study is to examine if endorectal magnetic resonance imaging (e-MRI) of the prostate could improve the detection of APC. PATIENTS AND METHODS: A retrospective review of 412 patients records with a clinical suspicion of prostate cancer (PCa) (prostate-specific antigen (PSA) levels >4 ng/ml or a suspicious finding on digital rectal examination (DRE)) who underwent conventional e-MRI (e-cMRI) and functional e-MRI (e-fMRI) of the prostate and subsequent prostate biopsy from April 2004 to July 2010 was conducted...
August 2016: Anticancer Research
https://www.readbyqxmd.com/read/27390960/electrocardiographic-measurement-of-infarct-size-compared-to-cardiac-mri-in-reperfused-first-time-st-segment-elevation-myocardial-infarction
#14
Lewis E Holmes, Tuan L Nguyen, Leia Hee, James Otton, Daniel A Moses, John K French, Liza Thomas, David A B Richards, Craig P Juergens
BACKGROUND: Myocardial infarct size (IS) following ST-segment elevation myocardial infarction (STEMI) is an important prognostic factor. We assessed the Selvester 32-point QRS score from the 12-lead ECG for measurement of IS in STEMI patients receiving reperfusion therapy compared to cardiac magnetic resonance imaging (CMRI). Furthermore we sought to explore the impact of microvascular obstruction (MVO) on the scoring system, and determine factors contributing to discrepancies between CMRI IS and Selvester score...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27380040/comparison-of-automated-brain-volumetry-methods-with-stereology-in-children-aged-2-to-3%C3%A2-years
#15
Kristina N Mayer, Beatrice Latal, Walter Knirsch, Ianina Scheer, Michael von Rhein, Bettina Reich, Jürgen Bauer, Kerstin Gummel, Neil Roberts, Ruth O'Gorman Tuura
INTRODUCTION: The accurate and precise measurement of brain volumes in young children is important for early identification of children with reduced brain volumes and an increased risk for neurodevelopmental impairment. Brain volumes can be measured from cerebral MRI (cMRI), but most neuroimaging tools used for cerebral segmentation and volumetry were developed for use in adults and have not been validated in infants or young children. Here, we investigate the feasibility and accuracy of three automated software methods (i...
September 2016: Neuroradiology
https://www.readbyqxmd.com/read/27350016/left-atrial-morphology-size-and-function-in-patients-with-transthyretin-cardiac-amyloidosis-and-primary-hypertrophic-cardiomyopathy%C3%A3-comparative-strain-imaging-study
#16
Cesare de Gregorio, Giuseppe Dattilo, Matteo Casale, Anna Terrizzi, Rocco Donato, Gianluca Di Bella
BACKGROUND: We sought to assess left atrial (LA) morphology and function in patients with transthyretin cardiac amyloidosis (TTR-CA) and hypertrophic cardiomyopathy (HCM). Primarily, longitudinal deformation (reservoir) and pump function were the focus of vector-velocity strain echocardiography imaging. METHODS AND RESULTS: The study group comprised 32 patients (mean age 57.7±15.4 years, 16 in each group), and 15 healthy controls. Diagnosis of TTR-CA was based on echocardiography and either gadolinium-enhanced (LGE) cardiac magnetic resonance (cMRI) or radionuclide imaging...
July 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27318345/-the-assessment-of-right-ventricular-function-in-patients-with-pulmonary-arterial-hypertension-with-cardiac-magnetic-resonance-imaging-a-meta-analysis
#17
Cui Qian, Ge Xihong, Yu Jing, Gao Guangfeng, Shen Wen
OBJECTIVE: To explore the clinical value of cardiac magnetic resonance imaging (CMRI) in assessment of right ventricular function in patients with pulmonary arterial hypertension (PAH). METHODS: The PubMed/MEDLINE, Wanfang data, CNKI (from January 2001 to April 2015) were searched. The search terms were pulmonary arterial hypertension, right ventricular function, and cardiac magnetic resonance imaging. An inclusion criterion was the patients suffering from PAH, and the healthy volunteers were served as controls...
December 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27273245/a-systematic-diagnostic-and-therapeutic-approach-for-the-treatment-of-patients-after-cardio-pulmonary-resuscitation-a-prospective-evaluation-of-212-patients-over-5%C3%A2-years
#18
Hubertus von Korn, Victor Stefan, Reyn van Ewijk, Kamalesh Chakraborty, Burkhard Sanwald, Jan Hemker, Ulrich Hink, Marc Ohlow, Bernward Lauer, Dierk Vagts, Stefan Gruene, Thomas Münzel
A literature on systematic treatment protocols for patients after resuscitation for cardiac arrest is lacking. We evaluated a systematic protocol, including ECG, echocardiogram, urgent cardiac catheterisation ("STEMI-like" workflow), CT scans, laboratory findings, IABP, hypothermia, and cMRI, prospectively over 5 years. The primary endpoint was the Cerebral Performance Category Scale (CPCS). During the period from January 2008 to December 2012, 212 patients were included. The mean age was 66.7 years, n = 151 (71...
June 8, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27249556/left-ventricular-mechanical-dispersion-is-associated-with-nonsustained-ventricular-tachycardia-in-hypertrophic-cardiomyopathy
#19
Mikko Jalanko, Mika Tarkiainen, Petri Sipola, Pertti Jääskeläinen, Kirsi Lauerma, Mika Laine, Markku S Nieminen, Markku Laakso, Tiina Heliö, Johanna Kuusisto
OBJECTIVE: We assessed the value of speckle tracking two-dimensional (2D) strain echocardiography (2DSE) measured mechanical dispersion (MD) with other imaging and electrocardiographic parameters in differentiating hypertrophic cardiomyopathy (HCM) patients with and without nonsustained ventricular tachycardia (NSVT) on 24-h ambulatory ECG monitoring. METHODS AND RESULTS: We studied 31 patients with HCM caused by the Finnish founder mutation MYBPC3-Q1061X and 20 control subjects with comprehensive 2DSE echocardiography and cardiac magnetic resonance imaging (CMRI)...
June 1, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27225018/danish-study-of-non-invasive-testing-in-coronary-artery-disease-dan-nicad-study-protocol-for-a-randomised-controlled-trial
#20
Louise Nissen, Simon Winther, Christin Isaksen, June Anita Ejlersen, Lau Brix, Grazina Urbonaviciene, Lars Frost, Lene Helleskov Madsen, Lars Lyhne Knudsen, Samuel Emil Schmidt, Niels Ramsing Holm, Michael Maeng, Mette Nyegaard, Hans Erik Bøtker, Morten Bøttcher
BACKGROUND: Coronary computed tomography angiography (CCTA) is an established method for ruling out coronary artery disease (CAD). Most patients referred for CCTA do not have CAD and only approximately 20-30 % of patients are subsequently referred to further testing by invasive coronary angiography (ICA) or non-invasive perfusion evaluation due to suspected obstructive CAD. In cases with severe calcifications, a discrepancy between CCTA and ICA often occurs, leading to the well-described, low-diagnostic specificity of CCTA...
May 26, 2016: Trials
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