Urokinasis

The aim of the study was to verify the validity of placement of a vena cava filter in patients with gynecologic cancer complicated by pulmonary embolism and progressive persistent hypercoagulability. The authors discuss two patients with pulmonary embolism. In this study, a gynecologic tumor was diagnosed, one presented endometrial carcinoma and the other ovarian papillary carcinoma, after the position of vena cava filter and treatment with urokinasi (2.800.000 UI/ml) it was possible to do surgery followed by radiation therapy in the first case and chemotherapy in the second...

The author has selected and updated four subjects in Plastic Surgery research. All flap monitoring procedures are detailed. They are still insufficient, as none of them can be used in all clinical situations. Free radicals have been implicated in the extension of necrosis after reperfusion of an ischaemic flap. Many substances have been tested for their scavenger action, particularly superoxide dismutase. Continuous intraarterial infusion of fibrinolytics is the treatment of the "no reflow phenomenon". A protocol with urokinasis, lidocaine and enoxaparine for ten days is used in our department with a 75% success rate...

Blood presence in anterior chamber in coagulated form raises special therapeutical problems. Even when the blood pressure is normal, it is not allowed to wait too much, because the clot doesn't have the tendency of fast resorption. They are emphasized the surgical difficulties, caused by a too large opening and by adherence of the clot to the iris, capsule of the lens and hyaloid, the necessity of use of a spatula for the detachment of the clot in case the urokinasis may not be used.

The fibrin seal (FS) is of indisputed value for hemostasis and atraumatic tissue synthesis in surgical therapy. In order to determine the optimal FS composition for resistance against fibrinolysis, in vivo lysis was tested by adding increasing amounts of the fibrinolysis-inhibitor aprotinine to 125I FS; urokinasis and plasminogen were administered in vitro while measuring protein and 125Iodine release. The correlation of protein and 125Iodine release clearly reflects the interdependence of both parameters; disjunction of radioactivity from the protein molecule was ruled out...