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https://www.readbyqxmd.com/read/28742348/an-observation-of-structural-wavepacket-motion-the-umbrella-mode-in-rydberg-excited-n-methyl-morpholine
#1
Yao Zhang, Sanghamitra Deb, Hannes Jonsson, Peter M M Weber
We have observed time-resolved, structural dynamics of a coherent vibrational wavepacket in Rydberg-excited N-methyl morpholine, a molecule with 48 internal degrees of freedom. The molecular structure was established by associating the time-dependent Rydberg electron binding energy, obtained from time-resolved photoionization-photoelectron spectroscopy, to the molecular structure using self-interaction corrected density functional calculations. Optical excitation at 226 nm launches an oscillatory wavepacket in the amine umbrella coordinate with a 650 fs period...
July 25, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28734882/opioid-prescribing-among-cancer-and-non-cancer-patients-time-trend-analysis-in-the-elderly-using-administrative-data
#2
Lisa Barbera, Rinku Sutradhar, Anna Chu, Hsien Seow, Doris Howell, Craig C Earle, Mary Ann O'Brien, Deb Dudgeon, Clare Atzema, Amna Husain, Ying Liu, Carlo DeAngelis
BACKGROUND: In 2007, Cancer Care Ontario introduced a provincial symptom screening program, which included pain, for cancer patients. Over this same time, opioid prescribing has been increasingly scrutinized among non-cancer patients. The study purpose was to see if opioid prescribing changed among older adults after 2007 in the context of changing opioid regulations, and whether effects were different among patients with a cancer history. METHODS: Ontario residents aged ≥65 were identified from 2004 to 2013...
July 19, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28733153/unsettling-moods-in-rural-midwifery-practice
#3
Susan Crowther, Liz Smythe, Deb Spence
BACKGROUND: Rural midwifery and maternity care is vulnerable due to geographical isolation, staffing recruitment and retention. Highlighting the concerns within rural midwifery is important for safe sustainable service delivery. METHOD: Hermeneutic phenomenological study undertaken in New Zealand (NZ). 13 participants were recruited in rural regions through snowball technique and interviewed. Transcribed interview data was interpretively analysed. Findings are discussed through the use of philosophical notions and related published literature...
July 18, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28731069/response-to-protocol-review-scenario-it-s-all-in-the-questions
#4
Marcy Brown, Deb Frolicher
No abstract text is available yet for this article.
July 20, 2017: Lab Animal
https://www.readbyqxmd.com/read/28727975/appendicular-biopsy-in-total-colonic-aganglionosis-a-histologically-challenging-and-inadvisable-practice
#5
Suravi Mohanty, Usha Kini, Kanishka Das, Divya Puttegowda, Lokendra Yadav, Manjally Kunjipapu Babu, Kiran Mahadevappa, Prasanna Kumar, Shubha Attibele Mahadevaiah, Mainak Deb
Background The reliability of intraoperative evaluation of ganglion cells in the appendix as a guide to a diagnosis of total colonic aganglionosis is unclear. Objective To evaluate the diagnostic utility of appendicular innervation in colonic Hirschsprung disease (HD) and TCA. Methods Prospective, systematic study of ganglion cells and the neural plexii in appendices from cases (HD and TCA) and age matched controls with frozen and paraffin sections, rapid acetylcholinesterase (AChE) and immunohistochemistry...
July 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28708742/physical-therapy-and-exercise-interventions-in-huntington-s-disease-a-mixed-methods-systematic-review-protocol
#6
Lori Quinn, Monica Busse, Judith Carrier, Nora Fritz, Jane Harden, Lynda Hartel, Deb Kegelmeyer, Anne Kloos, Ashwini Rao
The review seeks to evaluate the effectiveness of physical therapy and exercise interventions in Huntington's disease (HD). The review question is: What is the effectiveness of physiotherapy and therapeutic exercise interventions in people with HD, and what are patients', families' and caregivers' perceptions of these interventions?The specific objectives are:This mixed methods review seeks to develop an aggregated synthesis of quantitative, qualitative and narrative systematic reviews on physiotherapy and exercise interventions in HD, in an attempt to derive conclusions and recommendations useful for clinical practice and policy decision-making...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28706579/conventional-vs-drug-eluting-beads-transarterial-chemoembolization-for-hepatocellular-carcinoma
#7
REVIEW
Jeong Eun Song, Do Young Kim
Transarterial chemoembolization (TACE) is the current standard of therapy for patients with intermediate-stage hepatocellular carcinoma (HCC) according to the Barcelona Clinic Liver Cancer classification. The concept of conventional TACE (cTACE) is the selective obstruction of tumor-feeding artery by injection of chemotherapeutic agents, leading to ischemic necrosis of the target tumor via cytotoxic and ischemic effects. Drug-eluting beads (DEBs) have been imposed as novel drug-delivering agents for TACE, which allows for higher concentrations of drugs within the target tumor and lower systemic concentrations compared with cTACE...
June 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28706355/the-influence-of-acquisition-mode-on-the-dosimetric-performance-of-an-amorphous-silicon-electronic-portal-imaging-device
#8
Omemh Bawazeer, Sisira Herath, Siva Sarasanandarajah, Tomas Kron, Pradip Deb
AIMS: This study investigates the impact of cine acquisition mode on the dosimetric characteristics of a Varian aS500 amorphous silicon electronic portal imaging device (a-Si EPID). MATERIALS AND METHODS: The performance of an a-Si EPID operated in cine mode was assessed and compared to its performance when operated in an integrated mode and dose measurements using an ionization chamber. This study was conducted at different photon energies and the EPID performance was assessed as function of the delivered dose, dose rate, multileaf collimator speed, field size, phantom thickness, and intensity-modulated radiation therapy fields...
April 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28705184/prevalence-of-gestational-diabetes-mellitus-based-on-various-screening-strategies-in-western-kenya-a-prospective-comparison-of-point-of-care-diagnostic-methods
#9
Sonak D Pastakia, Benson Njuguna, Beryl Ajwang' Onyango, Sierra Washington, Astrid Christoffersen-Deb, Wycliffe K Kosgei, Ponnusamy Saravanan
BACKGROUND: Early diagnosis of gestational diabetes mellitus (GDM) is crucial to prevent short term delivery risks and long term effects such as cardiovascular and metabolic diseases in the mother and infant. Diagnosing GDM in Sub-Saharan Africa (SSA) however, remains sub-optimal due to associated logistical and cost barriers for resource-constrained populations. A cost-effective strategy to screen for GDM in such settings are therefore urgently required. We conducted this study to determine the prevalence of gestational diabetes mellitus (GDM) and assess utility of various GDM point of care (POC) screening strategies in a resource-constrained setting...
July 14, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28703277/mirnas-and-ovarian-cancer-an-overview
#10
REVIEW
Bornali Deb, Arif Uddin, Supriyo Chakraborty
Ovarian cancer (OC) is the sixth most common cancer in women globally. However, even with the advances in detection andtherapeutics it still represents the most dangerous gynecologic malignancy in women of the industrialized countries. The discovery of micro- RNAs (miRNA), a small noncoding RNA molecule targeting multiple mRNAs and regulation of gene expression by triggering translation repression and/or RNA degradation, has revealed the existence of a new array for regulation of genes involved in cancer. This review summarizes the current knowledge regarding the role of miRNAs expression in OC...
July 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28700244/targeted-yttrium-89-doxorubicin-drug-eluting-bead-a-safety-and-feasibility-pilot-study-in-a-rabbit-liver-cancer-model
#11
Johannes M Ludwig, Minzhi Xing, Yongkang Gai, Lingyi Sun, Dexing Zeng, Hyun S Kim
PURPOSE: To evaluate feasibility and safety of the cancer targeting (Radio)-Chemoembolization drug eluting bead (TRCE-DEB) concept drug SW43-DOX-L-NETA(89Y) DEB for the intra-arterial treatment of VX2 rabbit liver tumors. The treatment compound comprises of the Sigma-2 receptor ligand SW43 for cancer targeting, Doxorubicin (DOX), and 89Yttrium (89Y) as non-radioactive surrogate for therapeutic (Yttrium-90, Lutetium-177) and imaging (Yttrium-86) radioisotopes via the chelator L-NETA. MATERIAL AND METHODS: Ten New Zealand white rabbits with VX2 tumor allografts were used...
July 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28693512/a-prospective-quantitative-study-of-mental-health-act-assessments-in-england-following-the-2007-amendments-to-the-1983-act-did-the-changes-fulfill-their-promise
#12
Swaran P Singh, Moli Paul, Helen Parsons, Tom Burns, Peter Tyrer, Seena Fazel, Shoumitro Deb, Zoebia Islam, Jorun Rugkåsa, Ruchika Gajwani, Lavanya Thana, Michael J Crawford
BACKGROUND: In 2008, the Mental Health Act (MHA) 2007 amendments to the MHA 1983 were implemented in England and Wales. The amendments were intended to remove perceived obstacles to the detention of high risk patients with personality disorders (PDs), sexual deviance and learning disabilities (LDs). The AMEND study aimed to test the hypothesis that the implementation of these changes would lead to an increase in numbers or proportions of patients with these conditions who would be assessed and detained under the MHA 2007...
July 10, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28693115/assessment-of-insulin-like-growth-factor-1-and-igf-binding-protein-3-in-healthy-indian-girls-from-delhi-and-their-correlation-with-age-pubertal-status-obesity-and-thyroid-hormonal-status
#13
Raman K Marwaha, M K Garg, Sushil Gupta, A K Khurana, Archna Narang, Manoj Shukla, Preeti Arora, Aditi Chadha, Deb Datta Nayak, R K Manchanda
BACKGROUND: Population specific data and influence of sub-clinical hypothyroidism on insulin like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3) in Indian children is lacking. This study was undertaken to evaluate serum IGF-1 and IGFBP-3 and their correlation with age, gender, pubertal status and thyroid functions. METHODS: A total of 840 apparently healthy school girls aged 6-18 years, were recruited for the study and underwent assessment of height, weight, body mass index, pubertal status and serum T3, T4, TSH, IGF-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio...
June 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28687921/phylogenetic-analysis-of-newcastle-disease-viruses-from-bangladesh-suggests-continuing-evolution-of-genotype-xiii
#14
Lalita Rani Barman, Mohammed Nooruzzaman, Rahul Deb Sarker, Md Tazinur Rahman, Md Rajib Bin Saife, Mohammad Giasuddin, Bidhan Chandra Das, Priya Mohan Das, Emdadul Haque Chowdhury, Mohammad Rafiqul Islam
A total of 23 Newcastle disease virus (NDV) isolates from Bangladesh taken between 2010 and 2012 were characterized on the basis of partial F gene sequences. All the isolates belonged to genotype XIII of class II NDV but segregated into three sub-clusters. One sub-cluster with 17 isolates aligned with sub-genotype XIIIc. The other two sub-clusters were phylogenetically distinct from the previously described sub-genotypes XIIIa, XIIIb and XIIIc and could be candidates of new sub-genotypes; however, that needs to be validated through full-length F gene sequence data...
July 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28685382/safety-and-efficacy-of-transarterial-radioembolisation-in-patients-with-intermediate-or-advanced-stage-hepatocellular-carcinoma-refractory-to-chemoembolisation
#15
Elisabeth G Klompenhouwer, Raphaëla C Dresen, Chris Verslype, Annouschka Laenen, Gert De Hertogh, Christophe M Deroose, Lawrence Bonne, Vincent Vandevaveye, Geert Maleux
INTRODUCTION: Transarterial chemoembolisation (TACE) is the most widely used locoregional treatment for patients with an unresectable hepatocellular carcinoma (HCC). Transarterial radioembolisation (TARE) with yttrium-90 containing microspheres is an emerging interventional treatment that could be complementary or an alternative to TACE. AIM: To evaluate the safety and efficacy of TARE in patients with HCC who are refractory to TACE with drug-eluting beads (DEB-TACE)...
July 6, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28679539/a-glossary-of-terms-for-understanding-political-aspects-in-the-implementation-of-health-in-all-policies-hiap
#16
Goldameir Oneka, Faraz Vahid Shahidi, Carles Muntaner, Ahmed M Bayoumi, Deb Finn Mahabir, Alix Freiler, Patricia O'Campo, Ketan Shankardass
Health in All Policies (HiAP) is a strategy that seeks to integrate health considerations into the development, implementation and evaluation of policies across various non-health sectors of the government. Over the past 15 years, there has been an increase in the uptake of HiAP by local, regional and national governments. Despite the growing popularity of this approach, most existing literature on HiAP implementation remains descriptive rather than explanatory in its orientation. Moreover, prior research has focused on the more technical aspects of the implementation process...
July 5, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28678120/patient-outcomes-after-observation-versus-debridement-of-unstable-chondral-lesions-during-partial-meniscectomy-the-chondral-lesions-and-meniscus-procedures-champ-randomized-controlled-trial
#17
Leslie J Bisson, Melissa A Kluczynski, William M Wind, Marc S Fineberg, Geoffrey A Bernas, Michael A Rauh, John M Marzo, Zehua Zhou, Jiwei Zhao
BACKGROUND: It is unknown whether unstable chondral lesions observed during arthroscopic partial meniscectomy (APM) require treatment. We examined differences at 1 year with respect to knee pain and other outcomes between patients who had debridement (CL-Deb) and those who had observation (CL-noDeb) of unstable chondral lesions encountered during APM. METHODS: Patients who were ≥30 years old and undergoing APM were randomized to receive debridement (CL-Deb group; n = 98) or observation (CL-noDeb; n = 92) of unstable Outerbridge grade-II, III, or IV chondral lesions...
July 5, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28677067/intra-arterial-therapy-of-neuroendocrine-tumour-liver-metastases-comparing-conventional-tace-drug-eluting-beads-tace-and-yttrium-90-radioembolisation-as-treatment-options-using-a-propensity-score-analysis-model
#18
Duc Do Minh, Julius Chapiro, Boris Gorodetski, Qiang Huang, Cuihong Liu, Susanne Smolka, Lynn Jeanette Savic, David Wainstejn, MingDe Lin, Todd Schlachter, Bernhard Gebauer, Jean-François Geschwind
OBJECTIVES: To compare efficacy, survival outcome and prognostic factors of conventional transarterial chemoembolisation (cTACE), drug-eluting beads TACE (DEB-TACE) and yttrium-90 radioembolisation (Y90) for the treatment of liver metastases from gastroenteropancreatic (GEP) neuroendocrine tumours (NELM). METHODS: This retrospective analysis included 192 patients (58.6 years mean age, 56% men) with NELM treated with cTACE (N = 122), DEB-TACE (N = 26) or Y90 (N = 44) between 2000 and 2014...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28676199/the-art-score-is-not-an-effective-tool-for-optimizing-patient-selection-for-deb-tace-retreatment-a-multicentre-spanish-study
#19
Maria Pipa-Muñiz, Lluis Castells, Sonia Pascual, Javier Fernández-Castroagudín, Iratxe Díez-Miranda, Javier Irurzun, Roberto Díaz-Beveridge, María Senosiaín, Juan Arenas, Manuel de la Mata, Juan Turnes, María Isabel Monge-Romero, Daniel Pérez-Enguix, Javier Bustamante-Schneider, Nora Otegui, Esther Molina-Pérez, José Eduardo Rodríguez-Menéndez, Maria Varela
INTRODUCTION: The appropriate selection of hepatocellular carcinoma (HCC) patients who are eligible for transarterial chemoembolization (TACE) remains a challenge. The ART score has recently been proposed as a method of identifying patients who are eligible or not for a second TACE procedure. OBJECTIVE: To assess the validity of the Assessment for Retreatment with TACE (ART) score in a cohort of patients treated with drug-eluting bead TACE (DEB-TACE). SECONDARY OBJECTIVE: to identify clinical determinants associated with overall survival (OS)...
July 1, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28675310/effect-of-crude-protein-concentration-and-dietary-electrolyte-balance-on-litter-quality-foot-pad-dermatitis-growth-performance-and-processing-yields-in-two-medium-heavy-turkey-hybrids
#20
T Veldkamp, P M Hocking, L J Vinco
1. An experiment was conducted to investigate the effect of crude protein (CP) concentration and dietary electrolyte balance (DEB) on growth performance, processing yields, litter quality and foot pad dermatitis (FPD) in male turkeys from two commercial hybrids. Soya bean meal was replaced by vegetable protein sources selected for lower K concentrations to lower DEB in order to improve litter quality and subsequent quality of foot pads. 2. Effects of CP on litter friability and wetness were not consistent during the production period...
July 4, 2017: British Poultry Science
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