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https://www.readbyqxmd.com/read/28807257/revisiting-the-determinants-of-the-glomerular-filtration-barrier-what-goes-round-must-come-round
#1
Detlef Schlöndorff, Christina M Wyatt, Kirk N Campbell
The glomerular filtration barrier (GFB) is characterized by a very high hydraulic permeability, combined with a marked permselectivity that excludes macromolecules such as albumin. Thus, the GFB retains most of the plasma proteins, with only 0.06% of albumin getting across the basement membrane. The GFB consists of 3 layers: fenestrated endothelial cells, the glomerular basement membrane, and podocytes. Injury to any of these components can result in the development of proteinuria. The contribution of the major components of the GFB has recently been reexamined and is discussed in the context of our past and present understanding...
September 2017: Kidney International
https://www.readbyqxmd.com/read/28806378/gummy-smile-correction-using-lingual-orthodontics-and-augmented-corticotomy-in-extremely-thin-alveolar-housing
#2
Kyung-Yen Nahm, Seung-Yun Shin, Hyo-Won Ahn, Seong-Hun Kim, Gerald Nelson
BACKGROUND: Tooth movement out of anatomic limitations was assisted by augmented corticotomy using deproteinized bovine bone mineral. METHODS: Lip protrusion can be reduced by premolar extraction followed by retraction of the anterior teeth. Surgical intervention is appropriate when the alveolar bone housing of the anterior region is insufficient for the tooth movement. In this patient, corticotomy in upper palatal area and anterior segmented osteotomy in the mandible were performed...
August 10, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28801568/atomic-force-microscopy-reveals-the-dynamic-morphology-of-fenestrations-in-live-liver-sinusoidal-endothelial-cells
#3
B Zapotoczny, K Szafranska, K Owczarczyk, E Kus, S Chlopicki, M Szymonski
Here, we report an atomic force microscopy (AFM)-based imaging method for resolving the fine nanostructures (e.g., fenestrations) in the membranes of live primary murine liver sinusoidal endothelial cells (LSECs). From data on topographical and nanomechanical properties of the selected cell areas collected within 1 min, we traced the dynamic rearrangement of the cell actin cytoskeleton connected with the formation or closing of cell fenestrations, both in non-stimulated LSECs as well as in response to cytochalasin B and antimycin A...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799956/peripheral-blunt-dissection-using-a-microhoe-facilitated-method-for-descemet-membrane-endothelial-keratoplasty-donor-tissue-preparation
#4
Armand M Borovik, Mauricio Perez, Tova Lifshitz, Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Mahmood Showail, Amir Rosenblatt, David S Rootman
PURPOSE: To describe a modified technique for Descemet membrane donor tissue preparation that facilitates the original Melles stripping technique. METHODS: Descemet membrane is prepared using a Rootman/Goldich modified Sloane microhoe, using a blunt instrument as opposed to a sharp blade or needle and begins dissection within the trabecular meshwork. The trabecular tissue is dissected for 360 degrees, and then Descemet membrane is stripped to approximately 50%. A skin biopsy punch is then used to create fenestration in the cornea, which is used to mark an "F...
August 9, 2017: Cornea
https://www.readbyqxmd.com/read/28799689/fusion-and-scission-of-membranes-ubiquitous-topological-transformations-in-cells
#5
Roland L Knorr, Noboru Mizushima, Rumiana Dimova
2016 Nobel Prizes were awarded to Yoshinori Ohsumi for autophagy and to David Thouless, Duncan Haldane and Michael Kosterlitz for topological transitions. Both of these phenomena are intrinsically related when it comes to membranes. Here, we give a brief account on topological transformations of lipid membranes, commonly known as membrane fusion and membrane scission, and introduce the underlying topological invariant, the genus. The genus of a shape is a useful concept to distinguish unambiguously the processes of membrane fusion/scission and offers a simple method to describe complex, cellular membrane structures, such as fenestrated cristae...
August 11, 2017: Traffic
https://www.readbyqxmd.com/read/28798924/diagnostic-performance-of-high-resolution-computed-tomography-in-otosclerosis
#6
Todd Kanzara, Jagdeep Singh Virk
AIM: To determine the sensitivity and specificity of high resolution computed tomography (HRCT) in the diagnosis of otosclerosis. METHODS: A systematic literature review was undertaken to include Level I-III studies (Oxford Centre for Evidenced based Medicine) that utilised HRCT to detect histology confirmed otosclerosis. Quantitative synthesis was then performed. RESULTS: Based on available level III literature, HRCT has a relatively low sensitivity of 58% (95%CI: 49...
July 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28796562/loss-of-endothelial-planar-cell-polarity-and-cellular-clearance-mechanisms-in-age-related-macular-degeneration
#7
Maria Mercedes Campos, Mones S Abu-Asab
Apoptosis, autophagosomes, and lysosomes are lacking in the retinal pigment epithelium (RPE) of age-related macular degeneration (AMD) eyes. Necrosis, not apoptosis, appeared to be the prominent type of cell death in RPE, which led to the accumulation of cell debris within and on both sides of Bruch's membrane. The endothelium of the choriocapillaris had an altered planar cell polarity which encompassed the disappearance of fenestrations, the thickening of cytoplasm, and anterior nuclear dislocation. There were no significant differences in RPE and choroidal aberrations between macular and temporal regions...
August 10, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28795434/concomitant-antegrade-stent-grafting-of-the-descending-thoracic-aorta-during-transverse-hemiarch-reconstruction-for-acute-debakey-i-aortic-dissection-repair-improves-aortic-remodeling
#8
Ibrahim Sultan, Tyler J Wallen, Andreas Habertheuer, Mary Siki, George J Arnaoutakis, Joseph Bavaria, Wilson Y Szeto, Rita Milewski, Prashanth Vallabhajosyula
BACKGROUND AND AIM: Concomitant endovascular stent grafting of the descending thoracic aorta during open repair for acute DeBakey I aortic dissection can be performed in patients with extensive dissection and malperfusion. We analyzed the effects of this strategy on distal aortic remodeling. METHODS: From 2006-2014, acute DeBakey I dissection patients without primary aortic arch tear undergoing open distal hemiarch reconstruction (Standard group) versus those undergoing hemiarch with descending thoracic aorta (DTA) thoracic endovascular aortic repair (TEVAR group) were retrospectively reviewed...
August 9, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28776546/transarterial-embolization-for-treatment-of-symptomatic-polycystic-liver-disease-more-than-2-year-follow-up
#9
Jin-Long Zhang, Kai Yuan, Mao-Qiang Wang, Jie-Yu Yan, Hai-Nan Xin, Yan Wang, Feng-Yong Liu, Yan-Hua Bai, Zhi-Jun Wang, Feng Duan, Jin-Xin Fu
BACKGROUND: Currently, treatment of symptomatic polycystic liver disease (PLD) is still a challenging problem, especially for these patients who are not feasible for surgery. Minimally invasive options such as laparoscopic fenestration and percutaneous cyst aspiration with sclerotherapy demonstrated disappointing results due to multiple lesions. Because the cysts in PLD are mostly supplied from hepatic arteries but not from portal veins, transcatheter arterial embolization (TAE) of the hepatic artery branches that supply the major hepatic cysts can lead to shrinkage of the cyst and liver size, relieve symptoms, and improve nutritional status...
August 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28776225/forced-expression-of-vascular-endothelial-growth-factor-a-in-podocytes-decreases-mesangial-cell-numbers-and-attenuates-endothelial-cell-differentiation-in-the-mouse-glomerulus
#10
Masahiro Suyama, Yoichi Miyazaki, Taiji Matsusaka, Naoki Sugano, Hiroyuki Ueda, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo
BACKGROUND: Glomerular podocyte-derived vascular endothelial growth factor (VEGF) is indispensable for the migration and proliferation of glomerular endothelial cells. In contrast, podocyte-specific Vegf overexpression leads to the collapse of glomerular tufts; however, the mechanisms underlying this outcome have not yet been reported. METHODS: To further clarify the effects of elevated levels of Vegf expression on glomerular cells, we established a dual transgenic mouse line in which Vegf was exclusively and inducibly expressed in podocytes under the control of the "Tet-on system" (Podocin-rtTA/TetO-Vegf164 mice)...
August 3, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28768582/blind-overnight-a-case-of-fulminant-idiopathic-intracranial-hypertension
#11
Janpreet Singh Bhandohal, Taimur Mirza
Idiopathic Intracranial Hypertension (IIH) is a syndrome seen predominantly in obese women of reproductive age group, characterized by signs and symptoms of increased intracranial pressure due to an unknown cause. Some individuals have a more malignant form of disease called fulminant idiopathic intracranial hypertension with rapid worsening of symptoms over days. We report a case of 33year-old obese female (BMI 36.9) who presented with a severe headache and blurred vision for one week, found to have idiopathic intracranial hypertension with rapid worsening of symptoms suggestive of a fulminant course of disease...
July 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28765800/fortifying-the-bone-implant-interface-part-2-an-in-vivo-evaluation-of-3d-printed-and-tps-coated-triangular-implants
#12
Regina F MacBarb, Derek P Lindsey, Shane A Woods, Peggy A Lalor, Mukund I Gundanna, Scott A Yerby
BACKGROUND: Minimally invasive surgical fusion of the sacroiliac (SI) joint using machined solid triangular titanium plasma spray (TPS) coated implants has demonstrated positive clinical outcomes in SI joint pain patients. Additive manufactured (AM), i.e. 3D-printed, fenestrated triangular titanium implants with porous surfaces and bioactive agents, such as nanocrystalline hydroxyapatite (HA) or autograft, may further optimize bony fixation and subsequent biomechanical stability. METHODS: A bilateral ovine distal femoral defect model was used to evaluate the cancellous bone-implant interfaces of TPS-coated and AM implants...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28762152/quantitative-analysis-of-the-relationship-between-maxillary-incisors-and-the-incisive-canal-by-cone-beam-computed-tomography-in-an-adult-japanese-population
#13
Tomonari Matsumura, Yuji Ishida, Ayako Kawabe, Takashi Ono
BACKGROUND: In setting goals for orthodontic treatment, determining the morphologies of the alveolar bone and maxillary incisor root is important for avoiding root resorption, dehiscence, and fenestration. This study aimed to analyze the configurational relationships among maxillary incisors, the alveolar border, and the incisive canal by cone-beam computed tomography (CBCT). METHODS: Cone-beam CT images of 93 orthodontic patients were evaluated for length of the incisive canal (L); angles between the palatal plane and the maxillary alveolar border (θ1), the incisive canal (θ2), and maxillary incisor (θ3); distance from the left maxillary incisor to the incisive canal (D); and cross-sectional areas of the incisive canal (CSAs) at three vertical levels...
December 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/28761527/the-benefits-of-navigated-neuroendoscopy-in-children-with-multiloculated-hydrocephalus
#14
Sergei Afanasievich Kim, German Vladimirovich Letyagin, Vasiliy Evgenievich Danilin, Anna Alekseevna Sysoeva, Jamil Afetovich Rzaev, Galina Ivanovna Moisak
CONTEXT: Multiloculated hydrocephalus remains one of the most challenging neurosurgical problems. In this study, we use frameless navigation during endoscopic interventions to improve the efficiency of operations. SUBJECTS AND METHODS: Nine navigated endoscopic procedures were performed in 8 children with various forms of multiloculated hydrocephalus from March 2013 to June 2014. Preoperatively, the optimal entry point for fenestration of several cysts was determined on the basis of magnetic resonance data...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28758547/design-of-a-sensorized-guiding-catheter-for-in-situ-laser-fenestration-of-endovascular-stent
#15
Roberta Piazza, Sara Condino, Aldo Alberti, Raffaella Nice Berchiolli, Gioachino Coppi, Marco Gesi, Vincenzo Ferrari, Mauro Ferrari
PURPOSE: The in situ fenestration of a standard endograft is currently limited by difficulties in targeting the fenestration site under fluoroscopic control and by the lack of a safe method to perforate the graft. Evidence in the literature suggests the use of a 3 D electromagnetic navigator to accurately guide the endovascular instruments to the target and a laser to selectively perforate the graft. The aim of this work is to provide design guidelines to develop a sensorized catheter to guide the laser tool to the fenestration site and conduct preliminary testing of the feasibility of the proposed solution...
December 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/28754642/symptomatic-thoracic-nerve-root-herniation-into-an-extradural-arachnoid-cyst-case-report-and-review-of-the-literature
#16
Nagesh C Shanbhag, Ruurd F Duyff, Rob J M Groen
BACKGROUND: Spinal extradural arachnoid cysts (SEAC) are relatively rare and usually asymptomatic. They preferentially are situated in the thoracic extradural space, and almost always dorsal. SEACs may present with back pain and/or cord compression symptoms. Needle aspiration, needle fenestration or open surgical resection/fenestration have been reported as treatment modalities. CASE DESCRIPTION: We present a 35-year-old woman who complained of radiating pain from the right lower thoracic region of her back towards the right inguinal region which was aggravated upon defecation and straining...
July 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28754638/microvascular-decompression-for-trigeminal-neuralgia-using-a-novel-fenestrated-clip-and-tentorial-flap-technique
#17
Lain Hermes Gonzalez-Quarante, Fernando Ruiz-Juretschke, Vijay Agarwal, Roberto Garcia-Leal
BACKGROUND: Microvascular decompression (MVD) for neurovascular compression syndromes such as trigeminal neuralgia and hemifacial spasm has been traditionally described as an interposing technique using Teflon. Some alternative interposing materials have been proposed. Additionally, transposing techniques have been increasingly reported in recent years, as an alternative that may have a lower recurrence rate and fewer complications. OBJECTIVE: To describe our experience utilizing a technique consisting of transposition of the superior cerebellar artery using a fenestrated clip and a tentorial flap in patients with trigeminal neuralgia...
July 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28753091/neuroendoscopic-surgery-in-children-does-age-at-intervention-influence-safety-and-efficacy-a-single-center-experience
#18
Amy L Bowes, Josh King-Robson, William J Dawes, Greg James, Kristian Aquilina
OBJECTIVE The aim of this study was to review the safety of pediatric intraventricular endoscopy across separate age groups and to determine whether intraventricular endoscopy is associated with an increased risk of complications or reduced efficacy in infants younger than 1 year. METHODS In this retrospective cohort study, 286 pediatric patients younger than 17 years underwent intraventricular endoscopy at Great Ormond Street Hospital between December 2005 and December 2014. The primary diagnosis, procedure, and complications were recorded...
July 28, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28748863/in-vitro-stent-graft-fenestration-to-preserve-all-supra-aortic-branches-in-the-treatment-of-a-stanford-type-a-aortic-arch-dissection
#19
Tun Wang, Chang Shu, Ming Li, Alan Dardik, Quan-Ming Li
No abstract text is available yet for this article.
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28747079/endovascular-repair-of-a-thoracoabdominal-aortic-aneurysm-with-a-patient-specific-fenestrated-branched-stent-graft
#20
Bernardo C Mendes, Lawrence E Greiten, Gustavo S Oderich
PURPOSE: To describe the technical aspects of a thoracoabdominal aortic aneurysm (TAAA) repair using a patient-specific fenestrated-branched stent-graft. TECHNIQUE: The technique is demonstrated in a 69-year-old man with a 6.2-cm asymptomatic type III TAAA. A patient-specific fenestrated-branched stent-graft was designed with 2 down-going directional branches for the celiac and superior mesenteric arteries and 2 reinforced fenestrations for the renal arteries. The procedure was performed under general anesthesia and included sequential stenting of the celiac, superior mesenteric, and bilateral renal arteries...
July 1, 2017: Journal of Endovascular Therapy
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