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https://www.readbyqxmd.com/read/29147645/real-world-cure-rates-for-hepatitis-c-virus-treatments-that-include-simeprevir-and-or-sofosbuvir-are-comparable-to-clinical-trial-results
#1
Kian Bichoupan, Neeta Tandon, James F Crismale, Joshua Hartman, David Del Bello, Neal Patel, Sweta Chekuri, Alyson Harty, Michel Ng, Keith M Sigel, Meena B Bansal, Priya Grewal, Charissa Y Chang, Jennifer Leong, Gene Y Im, Lawrence U Liu, Joseph A Odin, Nancy Bach, Scott L Friedman, Thomas D Schiano, Ponni V Perumalswami, Douglas T Dieterich, Andrea D Branch
AIM: To assess the real-world effectiveness and cost of simeprevir (SMV), and/or sofosbuvir (SOF)-based therapy for chronic hepatitis C virus (HCV) infection. METHODS: The real-world performance of patients treated with SMV/SOF ± ribavirin (RBV), SOF/RBV, and SOF/RBV with pegylated-interferon (PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included...
November 12, 2017: World Journal of Virology
https://www.readbyqxmd.com/read/29100806/comparison-of-sacrificed-healthy-aorta-during-thoracoabdominal-aortic-aneurysm-repair-using-off-the-shelf-endovascular-branched-devices-and-open-surgery
#2
Luca Bertoglio, Tommaso Cambiaghi, Ciro Ferrer, Domenico Baccellieri, Fabio Verzini, Germano Melissano, Roberto Chiesa, Yamume Tshomba
BACKGROUND: Off-the-shelf devices for branched endovascular aortic repair of thoracoabdominal aortic aneurysm (TAAA) have been developed to overcome the manufacturing- and logistics-related delays characteristic of device customization. Nonetheless, the structural requirements of branched endovascular aortic repair, together with the need for additional thoracic components to suit different anatomies, might lead to a large sacrifice of healthy aorta. METHODS: We enrolled 18 consecutive TAAA patients treated between 2010 and 2016 in two centers employing the off-the-shelf t-Branch (Cook Medical, Bloomington, Ind) device (TB group)...
October 31, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29080792/impact-of-shear-rate-pattern-on-post-occlusive-near-infrared-spectroscopy-microvascular-reactivity
#3
M Ramos Gonzalez, J T Caldwell, P A Branch, G C Wardlow, C D Black, J Campbell, R D Larson, C J Ade
The primary aim of the present study was to determine the impact of acute changes in shear rate patterns, in particular retrograde shear rate, on microvascular function in 15 healthy, young men and women as determined via the post-occlusive near-infrared spectroscopy (NIRS) microvascular reactivity response. Microvascular reactivity, via NIRS-derived measurements of post-occlusion tissue saturation index (TSI%) and total microvascular hemoglobin+myoglobin concentration ([Hb]total), were assessed in each participant before and immediately after exposure to a 30min retrograde shear treatment...
October 31, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28739468/back-table-surgeon-modification-of-a-t-branch
#4
Martin Scheerbaum, Tilo Kölbel, Fiona Rohlffs, Franziska Heidemann, Sebastian E Debus, Nikolaos Tsilimparis
BACKGROUND: Surgeon modification of commercially available aortic stent grafts represents a salvage option to treat complex aortic pathologies in high-risk patients. TECHNIQUE: A 68-year-old male was referred to our hospital with a contained rupture of the visceral aorta. The patient was previously treated with an infrarenal tube graft 16 years earlier as well as with a Crawford procedure with island patch of the celiac trunk (TC) and the superior mesenteric artery (SMA) and bypasses to both renal arteries 6 years before admission...
July 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28739451/rescue-of-a-failing-endovascular-infrarenal-aortic-repair-using-an-off-the-shelf-branched-endograft
#5
Gino Gemayel, Gabriel Verdon, Nicolas Murith, Christoph Huber
BACKGROUND: Proximal aortic dilation following open and endovascular aortic repair (EVAR) is a well-known phenomenon. If severe enough, it may lead to late onset of type Ia endoleak that jeopardizes the proximal seal. METHODS: We report the case of a patient previously treated by EVAR for an infrarenal aneurysm who developed a type Ia endoleak after proximal aortic dilation. His aneurysms enlarged to 10 cm mandating a rapid repair without the delay for a custom-made device...
July 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28714225/leveraging-splice-affecting-variant-predictors-and-a-minigene-validation-system-to-identify-mendelian-disease-causing-variants-among-exon-captured-variants-of-uncertain-significance
#6
Zachry T Soens, Justin Branch, Shijing Wu, Zhisheng Yuan, Yumei Li, Hui Li, Keqing Wang, Mingchu Xu, Lavan Rajan, Fabiana L Motta, Renata T Simões, Irma Lopez-Solache, Radwan Ajlan, David G Birch, Peiquan Zhao, Fernanda B Porto, Juliana Sallum, Robert K Koenekoop, Ruifang Sui, Rui Chen
The genetic heterogeneity of Mendelian disorders results in a significant proportion of patients that are unable to be assigned a confident molecular diagnosis after conventional exon sequencing and variant interpretation. Here, we evaluated how many patients with an inherited retinal disease (IRD) have variants of uncertain significance (VUS) that are disrupting splicing in a known IRD gene by means other than affecting the canonical dinucleotide splice site. Three in silico splice-affecting variant predictors were leveraged to annotate and prioritize variants for splicing functional validation...
November 2017: Human Mutation
https://www.readbyqxmd.com/read/28483620/clinical-outcomes-of-spinal-cord-ischemia-after-fenestrated-and-branched-endovascular-stent-grafting-during-total-endovascular-aortic-repair-for-thoracoabdominal-aortic-aneurysms
#7
Takeshi Baba, Takao Ohki, Yuji Kanaoka, Koji Maeda, Hiroki Ohta, Soichirou Fukushima, Naoki Toya, Masayuki Hara
BACKGROUND: In this single-center study, we assessed the clinical outcomes of fenestrated endovascular aortic repair (f-EVAR) and branched EVAR on morbidity and mortality during total endovascular aortic repair for thoracoabdominal aortic aneurysms (TAAAs). METHODS: Between July 2006 and June 2015, elective f-EVAR and multibranched EVAR (t-Branch) for TAAAs were performed in 99 patients at our institution (Crawford classification types I [7], II [13], III [6], IV [55], and V [18])...
October 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28480257/does-adjunctive-tigecycline-improve-outcomes-in-severe-complicated-nonoperative-clostridium-difficile-infection
#8
Mary T LaSalvia, Westyn Branch-Elliman, Graham M Snyder, Monica V Mahoney, Carolyn D Alonso, Howard S Gold, Sharon B Wright
Severe Clostridium difficile infection is associated with a high rate of mortality; however, the optimal treatment for severe- complicated infection remains uncertain for patients who are not candidates for surgical intervention. Thus, we sought to evaluate the benefit of adjunctive tigecycline in this patient population using a retrospective cohort adjusted for propensity to receive tigecycline. We found that patients who received tigecycline had similar outcomes to those who did not, although the small sample size limited power to adjust for comorbidities and severity of illness...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28469811/factors-associated-with-success-of-telaprevir-and-boceprevir-based-triple-therapy-for-hepatitis-c-virus-infection
#9
Kian Bichoupan, Neeta Tandon, Valerie Martel-Laferriere, Neal M Patel, David Sachs, Michel Ng, Emily A Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, William Olson, Ponni V Perumalswami, Thomas D Schiano, Joseph A Odin, Lawrence U Liu, Douglas T Dieterich, Andrea D Branch
AIM: To evaluate new therapies for hepatitis C virus (HCV), data about real-world outcomes are needed. METHODS: Outcomes of 223 patients with genotype 1 HCV who started telaprevir- or boceprevir-based triple therapy (May 2011-March 2012) at the Mount Sinai Medical Center were analyzed. Human immunodeficiency virus-positive patients and patients who received a liver transplant were excluded. Factors associated with sustained virological response (SVR24) and relapse were analyzed by univariable and multivariable logistic regression as well as classification and regression trees...
April 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28366305/off-the-shelf-multibranched-endograft-for-urgent-endovascular-repair-of-thoracoabdominal-aortic-aneurysms
#10
Enrico Gallitto, Mauro Gargiulo, Antonio Freyrie, Rodolfo Pini, Chiara Mascoli, Stefano Ancetti, Gianluca Faggioli, Andrea Stella
OBJECTIVE: The aim of this paper was to report early and midterm results of endovascular repair of urgent thoracoabdominal aortic aneurysms (TAAAs) by the off-the-shelf multibranched Zenith t-Branch endograft (Cook Medical, Bloomington, Ind). METHODS: Between January 2014 and April 2016, all patients with urgent TAAAs (asymptomatic with diameter >8 cm, symptomatic, or ruptured TAAAs) and aortoiliac anatomic feasibility underwent endovascular repair by t-Branch and were prospectively enrolled...
September 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28164732/technical-aspects-of-implanting-the-t-branch-off-the-shelf-multibranched-stent-graft-for-thoracoabdominal-aneurysms
#11
Nikolaos Tsilimparis, Beatrice Fiorucci, Eike Sebastian Debus, Fiona Rohlffs, Tilo Kölbel
PURPOSE: To describe the planning and technique for implantation of the t-Branch off-the-shelf multibranched aortic endograft. TECHNIQUE: Total endovascular repair of thoracoabdominal aneurysms (TAAAs) with branched endografts is one of the most important paradigm shifts in the past decade. The t-Branch endograft, an off-the-shelf multibranched graft introduced in the European market in late 2012, allows treatment of patients with suitable anatomy in both the elective and urgent settings to avoid delays related to manufacturing time of custom-made devices...
June 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28115801/review-of-treatment-for-thoracoabdominal-aortic-aneurysm-and-the-modern-experience-of-multi-branched-endograft-in-taiwan
#12
REVIEW
Ting Chao Lin, Chun Che Shih
Thoracoabdominal aortic aneurysm (TAAA) is a complicated aortic disease. Most treatments for other aortic aneurysms have already shifted from conventional open surgery to endovascular operation; but for TAAA, open surgery remains the gold standard treatment. Several alternative treatments such as hybrid operation as well as endovascular techniques are utilized for the treatment of TAAA. Some of the procedures combine off-the-shelf devices such as the chimney procedure. Some other procedures required custom-made specialized stent grafts...
January 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27190318/a-novel-collaborative-community-based-hepatitis-b-screening-and-linkage-to-care-program-for-african-immigrants
#13
Hari Shankar, Demetri Blanas, Kian Bichoupan, Daouda Ndiaye, Ellie Carmody, Valerie Martel-Laferriere, Joan Culpepper-Morgan, Dougles T Dieterich, Andrea D Branch, Mulusew Bekele, Kim Nichols, Ponni V Perumalswami
BACKGROUND: Sub-Saharan African nations have among the highest rates of chronic hepatitis B virus (HBV) infection worldwide, but little is known about HBV infection in African-born persons in the United States. METHODS: From October 2011 to July 2013, community-based HBV screenings were conducted targeting persons originating from Africa in New York City. Persons were identified as currently HBV infected (HBsAg positive) or exposed (HBcAb positive). RESULTS: Overall, 955 persons were screened for HBV; the median age was 45 years (interquartile range, 35-54 years) and 75...
June 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27109801/endovascular-repair-of-thoracoabdominal-aortic-aneurysm-using-the-off-the-shelf-multibranched-t-branch-stent-graft
#14
Bernardo C Mendes, Gustavo S Oderich
Endovascular repair has been increasingly used to treat thoracoabdominal aortic aneurysms using patient-specific or off-the-shelf fenestrated and branched stent grafts. Device customization limits the application of patient-specific devices in patients who need urgent or emergency repair because of ruptured or large, rapidly expanding aneurysms. For these patients, an off-the-shelf multibranched stent graft, the t-Branch stent graft (Cook Medical, Bjaeverskov, Denmark) has been developed based on the relative predictability of visceral vessel anatomy, allowing incorporation and intraoperative customization of target vessels with four down-going directional branches...
May 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/26989855/high-baseline-bilirubin-and-low-albumin-predict-liver-decompensation-and-serious-adverse-events-in-hcv-infected-patients-treated-with-sofosbuvir-containing-regimens
#15
P V Perumalswami, N Patel, K Bichoupan, L Ku, R Yalamanchili, A Harty, D Motamed, V Khaitova, C Chang, P Grewal, L Liu, T D Schiano, M Woodward, D T Dieterich, A D Branch
To conduct surveillance and determine the safety profile of new hepatitis C virus treatments in real-world clinical practice. Hepatic decompensation and other serious adverse events were investigated in an observational cohort study of 511 patients treated with regimens containing sofosbuvir, December 2013-June 2014. Among 499 previously stable patients (no history of hepatic decompensation during the previous 12 months), a nested case-control study was performed to identify predictors of decompensation/serious adverse event...
September 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/26936665/real-world-sustained-virologic-response-rates-of-sofosbuvir-containing-regimens-in-patients-coinfected-with-hepatitis-c-and-hiv
#16
David Del Bello, Agnes Cha, Maria Sorbera, Kian Bichoupan, Calley Levine, Erin Doyle, Alyson Harty, Neal Patel, Michel Ng, Donald Gardenier, Joseph Odin, Thomas D Schiano, Daniel S Fierer, Leonard Berkowitz, Ponni V Perumalswami, Douglas T Dieterich, Andrea D Branch
BACKGROUND: Patients with hepatitis C virus (HCV) with or without human immunodeficiency virus (HIV) achieve high sustained virological response (SVR) rates on sofosbuvir (SOF)-containing regimens in clinical trials. Real world data on patients coinfected with HCV and HIV treated with SOF-based regimens are lacking. METHODS: This observational cohort study included HIV/HCV-coinfected adults with genotype 1 HCV who initiated treatment with a SOF-containing regimen between December 2013 and December 2014 (n = 89) at the Mount Sinai Hospital or the Brooklyn Hospital Center...
June 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/26763262/commentary-the-zenith-t-branch-endograft-what-have-we-learned-so-far
#17
COMMENT
Theodosios Bisdas, Martin Austermann
No abstract text is available yet for this article.
February 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/26637838/use-of-the-off-the-shelf-t-branch-device-to-treat-an-acute-type-ia-endoleak-in-a-symptomatic-juxtarenal-abdominal-aortic-aneurysm
#18
Adib Khanafer, Manar Khashram, Carmen-Maria Ruiz, Dana Mann, Andrew Laing
PURPOSE: To report the use of the off-the-shelf Zenith t-Branch Thoracoabdominal Endovascular Graft for the treatment of a symptomatic acute type Ia endoleak subsequent to previous infrarenal bifurcated endovascular aneurysm repair. CASE REPORT: A 72-year-old man presented 4 years after implantation of an Anaconda stent-graft with sac expansion and type II endoleak, which was treated over the next 18 months with repeated coil and glue embolization of the leak and sac...
February 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/26629916/the-relationship-between-vessel-traffic-and-noise-levels-received-by-killer-whales-orcinus-orca
#19
Juliana Houghton, Marla M Holt, Deborah A Giles, M Bradley Hanson, Candice K Emmons, Jeffrey T Hogan, Trevor A Branch, Glenn R VanBlaricom
Whale watching has become increasingly popular as an ecotourism activity around the globe and is beneficial for environmental education and local economies. Southern Resident killer whales (Orcinus orca) comprise an endangered population that is frequently observed by a large whale watching fleet in the inland waters of Washington state and British Columbia. One of the factors identified as a risk to recovery for the population is the effect of vessels and associated noise. An examination of the effects of vessels and associated noise on whale behavior utilized novel equipment to address limitations of previous studies...
2015: PloS One
https://www.readbyqxmd.com/read/26388883/spatial-development-of-transport-structures-in-apple-malus-%C3%A3-domestica-borkh-fruit
#20
Els Herremans, Pieter Verboven, Maarten L A T M Hertog, Dennis Cantre, Mattias van Dael, Thomas De Schryver, Luc Van Hoorebeke, Bart M Nicolaï
The void network and vascular system are important pathways for the transport of gases, water and solutes in apple fruit (Malus × domestica Borkh). Here we used X-ray micro-tomography at various spatial resolutions to investigate the growth of these transport structures in 3D during fruit development of "Jonagold" apple. The size of the void space and porosity in the cortex tissue increased considerably. In the core tissue, the porosity was consistently lower, and seemed to decrease toward the end of the maturation period...
2015: Frontiers in Plant Science
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