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Ludwig Apers, Tom Platteau, Séverine Caluwaerts
No abstract text is available yet for this article.
April 2018: Acta Clinica Belgica
Florent Duplan, Saran Davies, Serina Filler, Swaid Abdullah, Sophie Keyte, Hannah Newbury, Chris R Helps, Richard Wall, Séverine Tasker
BACKGROUND: Ticks derived from cats have rarely been evaluated for the presence of pathogens. The aim of this study was to determine the prevalence of Anaplasma phagocytophilum, Bartonella spp., haemoplasma species and Hepatozoon spp. in ticks collected from cats in the UK. METHODS: Five hundred and forty DNA samples extracted from 540 ticks collected from cats presenting to veterinarians in UK practices were used. Samples underwent a conventional generic PCR assay for detection of Hepatozoon spp...
March 20, 2018: Parasites & Vectors
Sahla Belhadj, Olfa Hentati, Ghaith Hamdaoui, Khaskhoussi Fakhreddine, Elisa Maillard, Stéphanie Dal, Séverine Sigrist
Hyperglycemia occurs during diabetes and insulin resistance. It causes oxidative stress by increasing reactive oxygen species (ROS) levels, leading to cellular damage. Polyphenols play a central role in defense against oxidative stress. In our study, we investigated the antioxidant properties of simmondsin, a pure molecule present in jojoba seeds, and of the aqueous extract of jojoba seeds on fructose-induced oxidative stress in RINm5f beta cells. The exposure of RINm5f beta cells to fructose triggered the loss of cell viability (-48%, p < 0...
March 20, 2018: Nutrients
Monique Piraud, Magali Pettazzoni, Pamela Lavoie, Séverine Ruet, Cécile Pagan, David Cheillan, Philippe Latour, Christine Vianey-Saban, Christiane Auray-Blais, Roseline Froissart
Tandem mass spectrometry (MS/MS) is a highly sensitive and specific technique. Thanks to the development of triple quadrupole analyzers, it is becoming more widely used in laboratories working in the field of inborn errors of metabolism. We review here the state of the art of this technique applied to the diagnosis of lysosomal storage disorders (LSDs) and how MS/MS has changed the diagnostic rationale in recent years. This fine technology brings more sensitive, specific, and reliable methods than the previous biochemical ones for the analysis of urinary glycosaminoglycans, oligosaccharides, and sialic acid...
March 19, 2018: Journal of Inherited Metabolic Disease
Bram Verstockt, Marc Ferrante, Séverine Vermeire, Gert Van Assche
The advent of anti-TNF agents has dramatically changed the treatment algorithms for IBD in the last 15 years, but primarily and more importantly secondary loss of response is often observed. Fortunately , new treatment options have been actively explored and some have already entered our clinical practice. In the class of anti-cytokine agents, the anti-IL12/IL23 monoclonal antibodies (mAbs) have entered clinical practice with the anti-p40 mAb ustekinumab in Crohn's disease (CD). Also, more selective anti-IL23 agents (anti-p19) have shown efficacy and are being further developed, in contrast to agents inhibiting IL-17 downstream which have failed in clinical trials despite their clear efficacy in psoriasis (Verstockt et al...
March 19, 2018: Journal of Gastroenterology
Charalampos Attipa, Laia Solano-Gallego, Kostas Papasouliotis, Francesca Soutter, David Morris, Chris Helps, Scott Carver, Séverine Tasker
BACKGROUND: In the Mediterranean basin, Leishmania infantum is a major cause of disease in dogs, which are frequently co-infected with other vector-borne pathogens (VBP). However, the associations between dogs with clinical leishmaniosis (ClinL) and VBP co-infections have not been studied. We assessed the risk of VBP infections in dogs with ClinL and healthy controls. METHODS: We conducted a prospective case-control study of dogs with ClinL (positive qPCR and ELISA antibody for L...
March 20, 2018: Parasites & Vectors
Camille Pouchieu, Clément Piel, Camille Carles, Anne Gruber, Catherine Helmer, Séverine Tual, Elisabeth Marcotullio, Pierre Lebailly, Isabelle Baldi
No abstract text is available yet for this article.
March 15, 2018: International Journal of Epidemiology
Stephane Olindo, Severine Jeannin, Martine Saint-Vil, Aissatou Signate, Mireille Edimonana-Kaptue, Julien Joux, Harold Merle, Pascale Richard, Samuel Granjeaud, Philippe Cabre, Didier Smadja, Raymond Cesaire, Agnes Lezin
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) has been discovered in 1980 and has been linked to tropical spastic paraparesis (HAM/TSP) in 1985 in Martinique. There is no data on HAM/TSP incidence trends. We report, in the present work, the temporal trends incidence of HAM/TSP in Martinique over 25 years. METHODS: Martinique is a Caribbean French West Indies island deserved by a unique Neurology Department involved in HAM/TSP diagnosis and management. A registry has been set up since 1986 and patients diagnosed for a HAM/TSP were prospectively registered...
March 19, 2018: PLoS Neglected Tropical Diseases
Lucine Vuitton, Elise Jacquin, Anne-Laure Parmentier, Elise Crochet, Francine Fein, Anne-Claire Dupont-Gossart, Laurianne Plastaras, Charles-Henri Bretagne, Frédéric Mauny, Stéphane Koch, Jean-Luc Prétet, Christiane Mougin, Séverine Valmary-Degano
BACKGROUND & AIMS: The increasing incidence of anal canal carcinomas requires better knowledge on anal human papillomavirus (HPV) infection. We aimed to assess anal canal HPV infection prevalence and risk factors among patients seen at a gastroenterology department in France. METHODS: We analyzed anal tissue samples collected from 469 consecutive patients (median age 54 years, 52% women), including 112 who received immunosuppressant therapies and 101 with inflammatory bowel disease (70 with Crohn's disease), who underwent colonoscopy examinations from April 1, 2012 to April 30, 2015...
March 15, 2018: Clinical Gastroenterology and Hepatology
Daniel J Merk, Jasmin Ohli, Natalie D Merk, Venu Thatikonda, Sorana Morrissy, Melanie Schoof, Susanne N Schmid, Luke Harrison, Severin Filser, Julia Ahlfeld, Serap Erkek, Kaamini Raithatha, Thomas Andreska, Marc Weißhaar, Michael Launspach, Julia E Neumann, Mehdi Shakarami, Dennis Plenker, Marco A Marra, Yisu Li, Andrew J Mungall, Richard A Moore, Yussanne Ma, Steven J M Jones, Beat Lutz, Birgit Ertl-Wagner, Andrea Rossi, Rabea Wagener, Reiner Siebert, Andreas Jung, Charles G Eberhart, Boleslaw Lach, Michael Sendtner, Stefan M Pfister, Michael D Taylor, Lukas Chavez, Marcel Kool, Ulrich Schüller
Recurrent mutations in chromatin modifiers are specifically prevalent in adolescent or adult patients with Sonic hedgehog-associated medulloblastoma (SHH MB). Here, we report that mutations in the acetyltransferase CREBBP have opposing effects during the development of the cerebellum, the primary site of origin of SHH MB. Our data reveal that loss of Crebbp in cerebellar granule neuron progenitors (GNPs) during embryonic development of mice compromises GNP development, in part by downregulation of brain-derived neurotrophic factor (Bdnf)...
March 9, 2018: Developmental Cell
Richard Sarro, Acadia A Kocher, Deena Emera, Severin Uebbing, Emily V Dutrow, Scott D Weatherbee, Timothy Nottoli, James P Noonan
Developmental gene expression patterns are orchestrated by thousands of distant-acting transcriptional enhancers. However, identifying enhancers essential for the expression of their target genes has proven challenging. Maps of long-range regulatory interactions may provide the means to identify enhancers critical for developmental gene expression. To investigate this hypothesis, we used circular chromosome conformation capture coupled with interaction maps in the mouse limb to characterize the regulatory topology of Pitx1 , which is essential for hindlimb development...
March 16, 2018: Development
Jérôme Gas, François-Xavier Nouhaud, Mathieu Roumiguié, Séverine Lagarde, Marie-Charlotte Delchier, Éric Huyghe, Michel Soulié, Xavier Gamé, Jean-Baptiste Beauval
PURPOSE: To evaluate the effectiveness of balloon nephrostomy (BN) for treating urinary tract fistulas. MATERIALS AND METHODS: In a single-center retrospective analysis, 56 patients were treated using BN between 2003 and 2014. All causes of urinary tract fistula were included. We assessed the effectiveness of drainage, complications, and the types of reconstruction surgery used. Success was defined as fistula closure without surgery. RESULTS: The cohort consisted of 25 males (54%) and 31 females (55%) with a median age of 63 years who underwent BN for a urinary fistula secondary to surgery, i...
March 15, 2018: International Urogynecology Journal
Anaïs Briot, Pauline Decaunes, Fanny Volat, Chloé Belles, Muriel Coupaye, Séverine Ledoux, Anne Bouloumié
OBJECTIVE: Adipose tissue (AT) dysfunction associated with obesity or aging is a major cause for lipid redistribution and the progression of cardiometabolic disorders. Our goal is to decipher the contribution of human AT microvascular endothelial cells (ECs) in the maintenance of fatty acid (FA) fluxes and the impact of senescence on their function. APPROACH AND RESULTS: We used freshly isolated primary microvascular ECs from human AT. Our data identified the endothelial FA handling machinery including FATPs (FA transport proteins) FATP1, FATP3, FATP4, and CD36 as well as FABP4 (FA binding protein 4)...
March 15, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Susen Burock, Severin Daum, Ulrich Keilholz, Konrad Neumann, Wolfgang Walther, Ulrike Stein
No abstract text is available yet for this article.
March 15, 2018: BMC Cancer
Lucie Angel, Badiâa Bouazzaoui, Michel Isingrini, Séverine Fay, Laurence Taconnat, Sandrine Vanneste, Moïse Ledoux, Valérie Gissot, Caroline Hommet, Fréderic Andersson, Laurent Barantin, Jean-Philippe Cottier, Jérémy Pasco, Thomas Desmidt, Frédéric Patat, Vincent Camus, Jean-Pierre Remenieras
Aging is characterized by a cognitive decline of fluid abilities and is also associated with electrophysiological changes. The vascular hypothesis proposes that brain is sensitive to vascular dysfunction which may accelerate age-related brain modifications and thus explain age-related neurocognitive decline. To test this hypothesis, cognitive performance was measured in 39 healthy participants from 20 to 80 years, using tests assessing inhibition, fluid intelligence, attention and crystallized abilities. Brain functioning associated with attentional abilities was assessed by measuring the P3b ERP component elicited through an auditory oddball paradigm...
March 12, 2018: Brain and Cognition
Monique J T Crobach, Jonathan J Vernon, Vivian G Loo, Ling Yuan Kong, Séverine Péchiné, Mark H Wilcox, Ed J Kuijper
Clostridium difficile is the main causative agent of antibiotic-associated and health care-associated infective diarrhea. Recently, there has been growing interest in alternative sources of C. difficile other than patients with Clostridium difficile infection (CDI) and the hospital environment. Notably, the role of C. difficile -colonized patients as a possible source of transmission has received attention. In this review, we present a comprehensive overview of the current understanding of C. difficile colonization...
April 2018: Clinical Microbiology Reviews
Michael Mccullagh, David Douce, Els Van Hoeck, Séverine Goscinny
A method using Ion Mobility Mass Spectrometry (IM-MS) and collision induced dissociation (CID) coupled with micro flow Ultra High Performance Chromatography (UPLC-IM-MS) has been developed to screen for steviol glycosides. Travelling wave ion mobility was used to determine rotationally averaged collision cross sections in nitrogen buffer gas (TWCCSN2). To illustrate the evolving applicability of ion mobility screening, the analytical approach was initially developed and applied to the analysis of a steviol/steviol glycoside spiked chocolate spread extract...
March 14, 2018: Analytical Chemistry
Severine L. Staub, Eckart Teubner, Nicola U. Zitzmann
The aim of this retrospective study was to investigate the clinical outcome of Dalbo®-Rotex® retention elements in a private practice. The majority of the retention elements was fixed with self-adhesive composite cement, and in almost 40% the exposed root surface was additionally covered with composite. The success rate of 96.3% after 24 months in a total of 50 included patients (response rate 48.5%) demonstrated that a simple and cost-effective fixation of removable dentures using prefabricated, chair-side inserted retention elements is feasible...
March 12, 2018: Swiss Dental Journal
Felicia Turowski, Ulrich Hügle, Arno Dormann, Matthias Bechtler, Ralf Jakobs, Uwe Gottschalk, Ellen Nötzel, Dirk Hartmann, Albrecht Lorenz, Frank Kolligs, Wilfried Veltzke-Schlieker, Andreas Adler, Olaf Becker, Bertram Wiedenmann, Nataly Bürgel, Hanno Tröger, Michael Schumann, Severin Daum, Britta Siegmund, Christian Bojarski
BACKGROUND AND AIMS: The aim of the study was to evaluate the usefulness and diagnostic and therapeutic outcome of the single-operator cholangiopancreatoscopy (SOC) with SpyGlassDS™. METHODS: In a retrospective multicenter study between November 2015 and January 2017, SpyGlassDS™ procedures were analyzed in participating centers. Indications, accuracy of SOC-guided biopsies, management of large bile duct stones, and complications were analyzed. Follow-up was 4 months...
March 12, 2018: Surgical Endoscopy
Séverine Sauzé, Céline Chouhan
International literature endorses an organisation of care which links up the hospital and the usual living environment of the elderly person as well as interdisciplinarity in the pathway of these vulnerable patients. The internal medicine and vascular diseases department of Angers university hospital favours these two principles and wishes to strenghten this strategy thanks to the intervention of a dedicated nurse and an occupational therapist. The aim is to prevent the early rehospitalisation of elderly people...
March 2018: Soins. Gérontologie
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