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https://www.readbyqxmd.com/read/28722585/school-children-s-intestinal-parasite-and-nutritional-status-1-year-after-complementary-school-garden-nutrition-water-sanitation-and-hygiene-interventions-in-burkina-faso
#1
Séverine Erismann, Serge Diagbouga, Christian Schindler, Peter Odermatt, Astrid M Knoblauch, Jana Gerold, Andrea Leuenberger, Akina Shrestha, Grissoum Tarnagda, Jürg Utzinger, Guéladio Cissé
The potential health benefits of combined agricultural, nutrition, water, sanitation, and hygiene (WASH) interventions are poorly understood. We aimed to determine whether complementary school garden, nutrition, and WASH interventions reduce intestinal parasites and improve school children's nutritional status in two regions of Burkina Faso. A cluster-randomized controlled trial was conducted in the Plateau Central and Center-Ouest regions of Burkina Faso. A total of 360 randomly selected children, aged 8-15 years, had complete baseline and end-line survey data...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721847/classical-scrapie-transmission-in-arr-arr-genotype-sheep
#2
Caroline Lacroux, Hervé Cassard, Hugh Simmons, Jean Yves Douet, Fabien Corbière, Severine Lugan, Pierette Costes, Naima Aron, Alvina Huor, Cécile Tillier, Francois Schelcher, Olivier Andreoletti
The ARR allele is considered to provide a very strong resistance against classical scrapie infection in sheep. In this study, we report the occurrence of clinical transmissible spongiform encephalopathy in ARR/ARR sheep, following their inoculation by the intracerebral route with a classical scrapie isolate. On first passage, the disease displayed an incomplete attack rate transmission, with incubation periods exceeding 6 years. On second passage, the obtained prion did not display better abilities to propagate than the original isolate...
July 18, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28720539/in-depth-experimental-analysis-of-pharmaceutical-twin-screw-wet-granulation-in-view-of-detailed-process-understanding
#3
Maxim Verstraeten, Daan Van Hauwermeiren, Kai Lee, Neil Turnbull, David Wilsdon, Mary Am Ende, Pankaj Doshi, Chris Vervaet, Davinia Brouckaert, Séverine T F C Mortier, Ingmar Nopens, Thomas De Beer
Twin-screw wet granulation is gaining increasing interest within the pharmaceutical industry for the continuous manufacturing of solid oral dosage forms. However, limited prior fundamental physical understanding has been generated relating to the granule formation mechanisms and kinetics along the internal compartmental length of a twin-screw granulator barrel, and about how process settings, barrel screw configuration and formulation properties such as particle size, density and surface properties influence these mechanisms...
July 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28719405/clinical-outcomes-1-year-after-empiric-131i-therapy-for-hyperthyroid-disorders-real-life-experience-and-predictive-factors-of-functional-response
#4
Lavinia Vija Racaru, Charlotte Fontan, Mathilde Bauriaud-Mallet, Séverine Brillouet, Olivier Caselles, Slimane Zerdoud, Delphine Bastié, Delphine Vallot, Philippe Caron, Manuel Bardiès, Frederic Courbon
: Radioiodine is a therapeutic option in Europe for Graves' disease (GD) and toxic multinodular goiter (MNG). PURPOSE: To compare empiric and calculated I activities using 2013 EANM recommendations. To look for predictive factors of therapeutic response to an empiric activity of I. To assess clinical situations favoring calculated treatment modalities. PATIENTS AND METHODS: Prospective monocentric study of clinical outcomes at 1 year follow-up in 86 patients with GD and MNG who received empiric I therapeutic activities (348-939 MBq)...
July 17, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28717571/visible-spectrum-extended-focus-optical-coherence-microscopy-for-label-free-sub-cellular-tomography
#5
Paul J Marchand, Arno Bouwens, Daniel Szlag, David Nguyen, Adrien Descloux, Miguel Sison, Séverine Coquoz, Jérôme Extermann, Theo Lasser
We present a novel extended-focus optical coherence microscope (OCM) attaining 0.7 μm axial and 0.4 μm lateral resolution maintained over a depth of 40 μm, while preserving the advantages of Fourier domain OCM. Our system uses an ultra-broad spectrum from a supercontinuum laser source. As the spectrum spans from near-infrared to visible wavelengths (240 nm in bandwidth), we call the system visOCM. The combination of such a broad spectrum with a high-NA objective creates an almost isotropic 3D submicron resolution...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28717570/chip-on-the-tip-compact-flexible-endoscopic-epifluorescence-video-microscope-for-in-vivo-imaging-in-medicine-and-biomedical-research
#6
Gregor Matz, Bernhard Messerschmidt, Werner Göbel, Severin Filser, Christian S Betz, Matthias Kirsch, Ortrud Uckermann, Marcel Kunze, Sven Flämig, André Ehrhardt, Klaus-Martin Irion, Mareike Haack, Mario M Dorostkar, Jochen Herms, Herbert Gross
We demonstrate a 60 mg light video-endomicroscope with a cylindrical shape of the rigid tip of only 1.6 mm diameter and 6.7 mm length. A novel implementation method of the illumination unit in the endomicroscope is presented. It allows for the illumination of the biological sample with fiber-coupled LED light at 455 nm and the imaging of the red-shifted fluorescence light above 500 nm in epi-direction. A large numerical aperture of 0.7 leads to a sub-cellular resolution and yields to high-contrast images within a field of view of 160 μm...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28716533/novel-ubqln2-mutations-linked-to-amyotrophic-lateral-sclerosis-and-atypical-hereditary-spastic-paraplegia-phenotype-through-defective-hsp70-mediated-proteolysis
#7
Elisa Teyssou, Laura Chartier, Maria-Del-Mar Amador, Roselina Lam, Géraldine Lautrette, Marie Nicol, Selma Machat, Sandra Da Barroca, Carine Moigneu, Mathilde Mairey, Thierry Larmonier, Safaa Saker, Christelle Dussert, Sylvie Forlani, Bertrand Fontaine, Danielle Seilhean, Delphine Bohl, Séverine Boillée, Vincent Meininger, Philippe Couratier, François Salachas, Giovanni Stevanin, Stéphanie Millecamps
Mutations in UBQLN2 have been associated with rare cases of X-linked juvenile and adult forms of amyotrophic lateral sclerosis (ALS) and ALS linked to frontotemporal dementia (FTD). Here, we report 1 known (c.1489C>T, p.Pro497Ser, P497S) and 3 novel (c.1481C>T, p.Pro494Leu, P494L; c.1498C>T, p.Pro500Ser, P500S; and c.1516C>G, p.Pro506Ala, P506A) missense mutations in the PXX domain of UBQLN2 in familial motor neuron diseases including ALS and spastic paraplegia (SP). A novel missense mutation (c...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28715202/antifouling-biomimetic-liquid-infused-stainless-steel-application-to-dairy-industrial-processing
#8
Sawsen Zouaghi, Thierry Six, Séverine Bellayer, Sona Moradi, Savvas G Hatzikiriakos, Thomas Dargent, Vincent Thomy, Yannick Coffinier, Christophe André, Guillaume Delaplace, Maude Jimenez
Fouling is a widespread and costly issue, faced by all food-processing industries. Particularly, in the dairy sector, where thermal treatments are mandatory to ensure product safety, heat-induced fouling represents up to 80% of the total production costs. Significant environmental impacts, due the massive consumption of water and energy, are also to deplore. Fouling control solutions are thus desperately needed, as they would lead to substantial financial gains, as well as tremendous progress toward eco-responsible processes...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28713434/first-insight-into-a-nationwide-genotypic-diversity-of-mycobacterium-tuberculosis-among-previously-treated-pulmonary-tuberculosis-cases-in-benin-west-africa
#9
Dissou Affolabi, N'Dira Sanoussi, Sergio Codo, Fréderic Sogbo, Prudence Wachinou, Faridath Massou, Aderemi Kehinde, Séverin Anagonou
BACKGROUND: Molecular studies on tuberculosis (TB) are rare in low-resource countries like Benin, where data on molecular study on previously treated TB cases is unavailable. MATERIALS AND METHODS: From January to December 2014, all smear- and culture-positive previously treated pulmonary TB patients from all TB clinics were systematically recruited. Drug susceptibility testing and spoligotyping were performed on all isolates. RESULTS: Of the 100 patients recruited, 71 (71...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28711990/assessment-of-braf-v600e-mutation-in-pulmonary-langerhans-cell-histiocytosis-in-tissue-biopsies-and-bronchoalveolar-lavages-by-droplet-digital-polymerase-chain-reaction
#10
Clémence Pierry, Charline Caumont, Elodie Blanchard, Camille Brochet, Gael Dournes, Audrey Gros, Thomas Bandres, Séverine Verdon, Marion Marty, Hugues Bégueret, Jean-Philippe Merlio
The neoplastic nature of pulmonary Langerhans cell histiocytosis (PLCH) is still debated. As the detection of BRAF (V600E) and MAP2K1 mutations in patients with PCLH is now considered for such assessment, the aim of our study was to evaluate digital droplet polymerase chain reaction (ddPCR) in PCLH diagnosis. We retrospectively analyzed BRAF(V600E) detection in a cohort of 42 PCLH tissues and 18 bronchoalveolar lavages (BALs) by ddPCR, immunohistochemistry, high-resolution melting PCR (HRM), and next-generation sequencing (NGS)...
July 15, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28710866/response-of-synthetic-diamond-detectors-in-proton-carbon-and-oxygen-ion-beams
#11
Séverine Rossomme, Marco Marinelli, Gianluca Verona-Rinati, Francesco Romano, G A Pablo Cirrone, Andrzej Kacperek, Stefaan Vynckier, Hugo Palmans
PURPOSE: In this work, the LET-dependence of the response of synthetic diamond detectors is investigated in different particle beams. METHOD: Measurements were performed in three non-modulated particle beams (proton, carbon and oxygen). The response of five synthetic diamond detectors was compared to the response of a Markus or an Advanced Markus ionization chamber. The synthetic diamond detectors were used with their axis parallel to the beam axis and without any bias voltage...
July 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28709062/cancer-incidence-in-the-agrican-cohort-study-2005-2011
#12
Clémentine Lemarchand, Séverine Tual, Noémie Levêque-Morlais, Stéphanie Perrier, Aurélien Belot, Michel Velten, Anne-Valérie Guizard, Elisabeth Marcotullio, Alain Monnereau, Bénédicte Clin, Isabelle Baldi, Pierre Lebailly
BACKGROUND: Numerous studies have been conducted among farmers, but very few of them have involved large prospective cohorts, and few have included a significant proportion of women and farm workers. Our aim was to compare cancer incidence in the cohort (overall, by sex, and by work on farm, occupational status and pesticide use) within the general population. METHODS: More than 180,000 participants in the AGRICAN cohort were matched to cancer registries to identify cancer cases diagnosed from enrolment (2005-2007) to 31st December 2011...
July 11, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28709047/persistence-of-immersed-blood-and-hair-dna-a-preliminary-study-based-on-casework
#13
Christophe Frippiat, Agathe Gastaldi, Séverine Van Grunderbeeck
In some cases, evidence is collected from rivers, canals, lakes or sink pipes. To determine the utility of analyzing these samples and for cases in which DNA was recovered from submerged bulletproof vest parts, we evaluated the time necessary to degrade the blood and, subsequently, DNA on bulletproof vests. In a second experiment, also based on cases, blood was diluted in water from a kitchen sink pipe and incubated at room temperature for different times. Subsequently, DNA quality was assessed. In a parallel experiment, hair roots were incubated in spring water for different time periods...
July 5, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28708882/evolution-of-the-scattering-properties-of-phytoplankton-cells-from-flow-cytometry-measurements
#14
William Moutier, Lucile Duforêt-Gaurier, Mélilotus Thyssen, Hubert Loisel, Xavier Mériaux, Lucie Courcot, David Dessailly, Anne-Hélène Rêve, Gérald Grégori, Séverine Alvain, Aude Barani, Laurent Brutier, Mathilde Dugenne
After the exponential growth phase, variability in the scattering efficiency of phytoplankton cells over their complete life cycle is not well characterised. Bulk measurements are impacted by senescent cells and detritrus. Thus the analysis of the evolution of the optical properties thanks to their morphological and/or intra-cellular variations remains poorly studied. Using the Cytosense flow cytometer (CytoBuoy b.v., NL), the temporal course of the forward and sideward efficiencies of two phytoplankton species (Thalassiosira pseudonana and Chlamydomonas concordia) were analyzed during a complete life-cycle...
2017: PloS One
https://www.readbyqxmd.com/read/28698230/chromoendoscopy-versus-narrow-band-imaging-in-uc-a-prospective-randomised-controlled-trial
#15
Raf Bisschops, Talat Bessissow, Joseph A Joseph, Filip Baert, Marc Ferrante, Vera Ballet, Hilde Willekens, Ingrid Demedts, Karel Geboes, Gert De Hertogh, Séverine Vermeire, Paul Rutgeerts, Gert Van Assche
BACKGROUND: Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE: To compare the performance of CE to VC for the detection of neoplastic lesions in patients with long-standing UC. DESIGN: A multicentre prospective randomised controlled trial...
July 11, 2017: Gut
https://www.readbyqxmd.com/read/28696956/long-term-outcomes-with-anti-tnf-therapy-and-accelerated-step-up-in-the-prospective-pediatric-belgian-crohn-s-disease-registry-belcro
#16
Lucas Wauters, Françoise Smets, Elisabeth De Greef, Patrick Bontems, Ilse Hoffman, Bruno Hauser, Philippe Alliet, Wim Arts, Harald Peeters, Stephanie Van Biervliet, Isabelle Paquot, Els Van de Vijver, Martine De Vos, Peter Bossuyt, Jean-François Rahier, Olivier Dewit, Tom Moreels, Denis Franchimont, Vincianne Muls, Fernand Fontaine, Edouard Louis, Jean-Charles Coche, Filip Baert, Jérôme Paul, Séverine Vermeire, Geneviève Veereman
BACKGROUND: Accelerated step-up or anti-tumor necrosis factor (TNF) before first remission is currently not recommended in pediatric Crohn's disease. METHODS: Five-year follow-up data from a prospective observational cohort of children diagnosed with Crohn's disease in Belgium were analyzed. Disease severity was scored as inactive, mild, or moderate to severe. Remission or inactive disease was defined as sustained if lasting ≥2 years. Univariate analyses were performed between anti-TNF-exposed versus naive patients and anti-TNF before versus after first remission and correlations assessed with primary outcomes average disease severity and sustained remission...
July 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28696638/-update-on-the-treatment-of-sarcoidosis
#17
Tamara Séverine Rochat, Jean-Paul Janssens, Paola M Soccal, Dan Adler
Sarcoidosis is a granulomatous disease characterized by variable manifestations and course. About 50% of patients will require systemic treatment, while the remaining will present spontaneous resolution of the disease. When a systemic therapy is necessary, it is prolonged and relapse rate is high when it is discontinued. Systemic corticosteroids are the first line treatment in sarcoidosis. Because of many side effects, it is essential to consider other drugs in case of intolerance to steroids, as steroid-sparing agents, or in case of inefficiency of corticotherapy alone...
November 16, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28696574/divergent-asymmetric-synthesis-of-polycyclic-compounds-via-vinyl-triazenes
#18
Kay Severin, David Kossler, Florian Perrin, Abdusalom Suleymanov, Gregor Kiefer, Rosario Scopelliti, Nicolai Cramer
Vinyl triazenes are obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1-alkynyltriazenes in the presence of a RuII-catalyst with a chiral cyclopentadienyl ligand. The triazenes serve as unique vinyl cation surrogates. Under acidic conditions, the triazene functionality can be replaced by a variety of groups including halides, alkoxides, sulfoxides, amides, arenes and heteroarenes, providing efficient access to a pool of chiral polycyclic compounds.
July 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28691770/influence-of-the-water-phase-state-on-the-thermodynamics-of-aqueous-phase-reforming-for-hydrogen-production
#19
Séverine Le Gac, Renée M Ripken, Jan Meuldijk, Johannes G E Gardeniers
Hydrogen is a promising renewable energy source that can be produced from biomass using Aqueous Phase Reforming (APR). Here, using data obtained from AspenPlus and the literature, we evaluated the phase state, temperature-dependent enthalpy, and Gibbs free energy for the APR of small biomass model substrates. Phase equilibrium studies reveal that, under typical APR reaction conditions, the reaction mixture is in the liquid phase. Therefore, we show for the first time that the water-gas-shift (WGS), which is the second main reaction of APR, must be modeled in the liquid phase, resulting in an endothermic instead of an exothermic enthalpy of reaction...
July 10, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28687751/the-interaction-of-the-bioinsecticide-pa1b-pea-albumin-1-subunit-b-with-the-insect-v-atpase-triggers-apoptosis
#20
Vanessa Eyraud, Séverine Balmand, Lamis Karaki, Isabelle Rahioui, Catherine Sivignon, Agnès F Delmas, Corinne Royer, Yvan Rahbé, Pedro Da Silva, Frédéric Gressent
PA1b (Pea Albumin 1, subunit b) peptide is an entomotoxin, extracted from Legume seeds, with a lethal activity towards several insect pests, such as mosquitoes, some aphids and cereal weevils. This toxin acts by binding to the subunits c and e of the plasma membrane H(+)-ATPase (V-ATPase) in the insect midgut. In this study, two cereal weevils, the sensitive Sitophilus oryzae strain WAA42, the resistance Sitophilus oryzae strain ISOR3 and the insensitive red flour beetle Tribolium castaneum, were used in biochemical and histological experiments to demonstrate that a PA1b/V-ATPase interaction triggers the apoptosis mechanism, resulting in insect death...
July 7, 2017: Scientific Reports
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