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https://www.readbyqxmd.com/read/28319715/small-area-spatiotemporal-analysis-of-heatwave-impacts-on-elderly-mortality-in-paris-a-cluster-analysis-approach
#1
Tarik Benmarhnia, Wahida Kihal-Talantikite, Martina S Ragettli, Séverine Deguen
BACKGROUND: Heat-waves have a substantial public health burden. Understanding spatial heterogeneity at a fine spatial scale in relation to heat and related mortality is central to target interventions towards vulnerable communities. OBJECTIVES: To determine the spatial variability of heat-wave-related mortality risk among elderly in Paris, France at the census block level. We also aimed to assess area-level social and environmental determinants of high mortality risk within Paris...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28318776/-a-case-of-lung-infection-imported-from-the-united-states
#2
Julien Calvani, Séverine Feuillet, Peter Dorfmuller, Vincent Thomas de Montpréville, Sacha Mussot, Maria Rosa Ghigna
No abstract text is available yet for this article.
March 16, 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28317993/capturing-the-multiscale-dynamics-of-membrane-protein-complexes-with-all-atom-mixed-resolution-and-coarse-grained-models
#3
Chenyi Liao, Xiaochuan Zhao, Jiyuan Liu, Severin T Schneebeli, John C Shelley, Jianing Li
The structures and dynamics of protein complexes are often challenging to model in heterogeneous environments such as biological membranes. Herein, we meet this fundamental challenge at attainable cost with all-atom, mixed-resolution, and coarse-grained models of vital membrane proteins. We systematically simulated five complex models formed by two distinct G protein-coupled receptors (GPCRs) in the lipid-bilayer membrane on the ns-to-μs timescales. These models, which suggest the swinging motion of an intracellular loop, for the first time, provide the molecular details for the regulatory role of such a loop...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28302067/erratum-to-aquaculture-genomics-genetics-and-breeding-in-the-united-states-current-status-challenges-and-priorities-for-future-research
#4
Hisham Abdelrahman, Mohamed ElHady, Acacia Alcivar-Warren, Standish Allen, Rafet Al-Tobasei, Lisui Bao, Ben Beck, Harvey Blackburn, Brian Bosworth, John Buchanan, Jesse Chappell, William Daniels, Sheng Dong, Rex Dunham, Evan Durland, Ahmed Elaswad, Marta Gomez-Chiarri, Kamal Gosh, Ximing Guo, Perry Hackett, Terry Hanson, Dennis Hedgecock, Tiffany Howard, Leigh Holland, Molly Jackson, Yulin Jin, Karim Khalil, Thomas Kocher, Tim Leeds, Ning Li, Lauren Lindsey, Shikai Liu, Zhanjiang Liu, Kyle Martin, Romi Novriadi, Ramjie Odin, Yniv Palti, Eric Peatman, Dina Proestou, Guyu Qin, Benjamin Reading, Caird Rexroad, Steven Roberts, Mohamed Salem, Andrew Severin, Huitong Shi, Craig Shoemaker, Sheila Stiles, Suxu Tan, Kathy F J Tang, Wilawan Thongda, Terrence Tiersch, Joseph Tomasso, Wendy Tri Prabowo, Roger Vallejo, Hein van der Steen, Khoi Vo, Geoff Waldbieser, Hanping Wang, Xiaozhu Wang, Jianhai Xiang, Yujia Yang, Roger Yant, Zihao Yuan, Qifan Zeng, Tao Zhou
No abstract text is available yet for this article.
March 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28296881/transcriptomic-responses-to-environmental-temperature-by-turtles-with-temperature-dependent-and-genotypic-sex-determination-assessed-by-rnaseq-inform-the-genetic-architecture-of-embryonic-gonadal-development
#5
Srihari Radhakrishnan, Robert Literman, Jennifer Neuwald, Andrew Severin, Nicole Valenzuela
Vertebrate sexual fate is decided primarily by the individual's genotype (GSD), by the environmental temperature during development (TSD), or both. Turtles exhibit TSD and GSD, making them ideal to study the evolution of sex determination. Here we analyze temperature-specific gonadal transcriptomes (RNA-sequencing validated by qPCR) of painted turtles (Chrysemys picta TSD) before and during the thermosensitive period, and at equivalent stages in soft-shell turtles (Apalone spinifera-GSD), to test whether TSD's and GSD's transcriptional circuitry is identical but deployed differently between mechanisms...
2017: PloS One
https://www.readbyqxmd.com/read/28296797/improvements-in-spectrum-s-fit-to-program-data-tool
#6
Severin G Mahiane, Kimberly Marsh, Kelsey Grantham, Shawna Crichlow, Karen Caceres, John Stover
OBJECTIVE: The Joint United Nations Program on HIV/AIDS-supported Spectrum software package (Glastonbury, Connecticut, USA) is used by most countries worldwide to monitor the HIV epidemic. In Spectrum, HIV incidence trends among adults (aged 15-49 years) are derived by either fitting to seroprevalence surveillance and survey data or generating curves consistent with program and vital registration data, such as historical trends in the number of newly diagnosed infections or people living with HIV and AIDS related deaths...
April 2017: AIDS
https://www.readbyqxmd.com/read/28296236/development-of-the-endocrine-pancreas-in-the-beagle-dog-from-fetal-to-adult-life
#7
Emilie Bricout-Neveu, Severine Pechberty, Karine Reynaud, Cindy Maenhoudt, Marie José Lecomte, Philippe Ravassard, Paul Czernichow
Our objectives were to describe, in Beagle dogs, the ontogenesis of beta (insulin-producing) and alpha (glucagon-producing) cells from fetal to early postnatal life and adulthood. In addition, to have some insight into interspecies comparison, Beagle dog pancreases were compared to pancreases from a Labrador and Chow Chow. At midgestation, the epithelium was dense, beta cells scarce, and alpha cells numerous and concentrated in the center of the pancreatic bud. From 36 to 45 days post conception (pc), beta cell numbers increased and the epithelium expanded and branched out...
March 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28294977/phosphoinositides-major-actors-in-membrane-trafficking-and-lipid-signaling-pathways
#8
REVIEW
Johan-Owen De Craene, Dimitri L Bertazzi, Séverine Bär, Sylvie Friant
Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics. Although detected in small concentrations in membranes, their role is essential to cell function, since imbalance in their concentrations is a hallmark of many cancers. Their synthesis involves phosphorylating/dephosphorylating positions D3, D4 and/or D5 of their inositol ring by specific lipid kinases and phosphatases...
March 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28285597/prevalence-study-and-risk-factor-analysis-of-selected-bacterial-protozoal-and-viral-including-vector-borne-pathogens-in-cats-from-cyprus
#9
Charalampos Attipa, Kostas Papasouliotis, Laia Solano-Gallego, Gad Baneth, Yaarit Nachum-Biala, Elpida Sarvani, Toby G Knowles, Sena Mengi, David Morris, Chris Helps, Séverine Tasker
BACKGROUND: Feline infectious agent studies are lacking in Cyprus. The aims of this study were to determine the prevalence and risk factors for various feline infectious agents, including feline vector-borne pathogens (FVBP), in cats from Cyprus. METHODS: A cross-sectional, descriptive, multicentre study was performed on 174 feline samples [138 owned and 36 shelter-feral, including both healthy (43) and non-healthy (131), cats] from private veterinary clinics from all six districts of Cyprus...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28284285/-therapeutic-approaches-in-court-ordered-therapy
#10
Emmanuelle Floris, Arnaud De Jésus, Jean-Philippe Cano, Séverine Raymondaud, Éric Rouveyrol, Jean-Pierre Bouchard
As is the case with other contexts of mental health treatments, the therapeutic approaches to court-ordered therapy are varied. They are based on the principle of their clinical indication and must be delivered by therapists trained in the specific area. The classic therapeutic approaches are used: medication, psychoanalysis and psychoanalytically inspired therapies, cognitive behavioural therapies, group therapies and body-oriented approach.
March 2017: Soins. Psychiatrie
https://www.readbyqxmd.com/read/28283295/global-metabolome-changes-induced-by-cyanobacterial-blooms-in-three-representative-fish-species
#11
Benoît Sotton, Alain Paris, Séverine Le Manach, Alain Blond, Gérard Lacroix, Alexis Millot, Charlotte Duval, Qin Qiao, Arnaud Catherine, Benjamin Marie
Cyanobacterial blooms induce important ecological constraints for aquatic organisms and strongly impact the functioning of aquatic ecosystems. In the past decades, the effects of the cyanobacterial secondary metabolites, so called cyanotoxins, have been extensively studied in fish. However, many of these studies have used targeted approaches on specific molecules, which are thought to react to the presence of these specific cyanobacterial compounds. Since a few years, untargeted metabolomic approaches provide a unique opportunity to evaluate the global response of hundreds of metabolites at a glance...
March 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28282858/the-impact-of-shiftwork-on-skeletal-muscle-health
#12
REVIEW
Brad Aisbett, Dominique Condo, Evelyn Zacharewicz, Séverine Lamon
(1) Background: About one in four workers undertake shift rosters that fall outside the traditional 7 a.m.-6 p.m. scheduling. Shiftwork alters workers' exposure to natural and artificial light, sleep patterns, and feeding patterns. When compared to the rest of the working population, shiftworkers are at a greater risk of developing metabolic impairments over time. One fundamental component of metabolic health is skeletal muscle, the largest organ in the body. However, cause-and-effect relationships between shiftwork and skeletal muscle health have not been established; (2) Methods: A critical review of the literature was completed using online databases and reference lists; (3) Results: We propose a conceptual model drawing relationships between typical shiftwork consequences; altered light exposure, sleep patterns, and food and beverage consumption, and drivers of skeletal muscle health-protein intake, resistance training, and hormone release...
March 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28281692/ibuprofen-results-in-alterations-of-human-fetal-testis-development
#13
Millissia Ben Maamar, Laurianne Lesné, Kristin Hennig, Christèle Desdoits-Lethimonier, Karen R Kilcoyne, Isabelle Coiffec, Antoine D Rolland, Cécile Chevrier, David M Kristensen, Vincent Lavoué, Jean-Philippe Antignac, Bruno Le Bizec, Nathalie Dejucq-Rainsford, Rod T Mitchell, Séverine Mazaud-Guittot, Bernard Jégou
Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown whether ibuprofen could act as an endocrine disruptor as reported for fellow analgesics paracetamol and aspirin. To investigate this, we exposed human fetal testes (7-17 gestational weeks (GW)) to ibuprofen using ex vivo culture and xenograft systems. Ibuprofen suppressed testosterone and Leydig cell hormone INSL3 during culture of 8-9 GW fetal testes with concomitant reduction in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28278231/the-human-plasma-metabolome-reference-values-in-800-french-healthy-volunteers-impact-of-cholesterol-gender-and-age
#14
Séverine Trabado, Abdallah Al-Salameh, Vincent Croixmarie, Perrine Masson, Emmanuelle Corruble, Bruno Fève, Romain Colle, Laurent Ripoll, Bernard Walther, Claire Boursier-Neyret, Erwan Werner, Laurent Becquemont, Philippe Chanson
Metabolomic approaches are increasingly used to identify new disease biomarkers, yet normal values of many plasma metabolites remain poorly defined. The aim of this study was to define the "normal" metabolome in healthy volunteers. We included 800 French volunteers aged between 18 and 86, equally distributed according to sex, free of any medication and considered healthy on the basis of their medical history, clinical examination and standard laboratory tests. We quantified 185 plasma metabolites, including amino acids, biogenic amines, acylcarnitines, phosphatidylcholines, sphingomyelins and hexose, using tandem mass spectrometry with the Biocrates AbsoluteIDQ p180 kit...
2017: PloS One
https://www.readbyqxmd.com/read/28276723/detection-of-blood-volumes-and-haemoglobin-mass-by-means-of-co-re-breathing-and-indocyanine-green-and-sodium-fluorescein-injections
#15
Stefanie Keiser, Anne-Kristine Meinild-Lundby, Thomas Steiner, Severin Trösch, Sven Rauber, Alexander Krafft, Tilo Burkhardt, Matthias Peter Hilty, Christoph Siebenmann, Jon Peter Wehrlin, Carsten Lundby
The main aim of the present study was to quantify the magnitude of differences introduced when estimating a given blood volume compartment (e.g. plasma volume) through the direct determination of another compartment (e.g. red cell volume) by multiplication of venous haematocrit and/or haemoglobin concentration. However, since whole body haematocrit is higher than venous haematocrit such an approach might comprise certain errors. To test this experimentally, four different methods for detecting blood volumes and haemoglobin mass (Hbmass) were compared, namely the carbon monoxide (CO) re-breathing (for Hbmass), the indocyanine green (ICG; for plasma volume [PV]) and the sodium fluorescein (SoF; for red blood cell volume [RBCV]) methods...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28274145/emerging-monoclonal-antibodies-against-clostridium-difficile-infection
#16
Séverine Péchiné, Claire Janoir, Anne Collignon
Clostridium difficile infections are characterized by a high recurrence rate despite antibiotic treatments and there is an urgent need to develop new treatments such as fecal transplantation and immonotherapy. Besides active immunotherapy with vaccines, passive immunotherapy has shown promise, especially with monoclonal antibodies. Areas covered: Herein, the authors review the different assays performed with monoclonal antibodies against C. difficile toxins and surface proteins to treat or prevent primary or recurrent episodes of C...
April 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28271595/independent-academic-data-monitoring-committees-for-clinical-trials-in-cardiovascular-and-cardiometabolic-diseases
#17
Gerasimos S Filippatos, Pieter de Graeff, Jeroen J Bax, John-Joseph Borg, John G F Cleland, Henry J Dargie, Marcus Flather, Ian Ford, Tim Friede, Barry Greenberg, Cécile Henon-Goburdhun, Richard Holcomb, Bradley Horst, John Lekakis, Guenther Mueller-Velten, Athanasios G Papavassiliou, Krishna Prasad, Giuseppe M C Rosano, Thomas Severin, Warren Sherman, Wendy Gattis Stough, Karl Swedberg, Luigi Tavazzi, Dimitris Tousoulis, Panagiotis Vardas, Frank Ruschitzka, Stefan D Anker
Data Monitoring Committees (DMCs) play a crucial role in the conducting of clinical trials to ensure the safety of study participants and to maintain a trial's scientific integrity. Generally accepted standards exist for DMC composition and operational conduct. However, some relevant issues are not specifically addressed in current guidance documents, resulting in uncertainties regarding optimal approaches for communication between the DMC, steering committee, and sponsors, release of information, and liability protection for DMC members...
March 8, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28263032/impact-of-arteriovenous-fistula-cannulation-on-the-quality-of-dialysis
#18
Michelle Elias, Erika Nnang-Obada, Bernard Charpentier, Antoine Durrbach, Severine Beaudreuil
INTRODUCTION: Adequate hemodialysis directly improves health. Puncturing an arteriovenous fistula (AVF) and the amount of blood recirculation greatly affect the quality of dialysis. Few studies have assessed the method to cannulate a fistula and its influence on efficiency of hemodialysis. METHODS: This prospective pilot study included 14 patients with end-stage renal failure receiving regular intermittent hemodialysis. Patients received three consecutive treatments with both needles directed upstream then three consecutive treatments with the venous needle directed upstream and the arterial needle directed downstream...
March 6, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28262279/major-influence-of-interobserver-reliability-on-polytrauma-identification-with-the-injury-severity-score-iss-time-for-a-centralised-coding-in-trauma-registries
#19
Roman Maduz, Patrick Kugelmeier, Severin Meili, Robert Döring, Christoph Meier, Peter Wahl
OBJECTIVE: The Abbreviated Injury Scale (AIS) and the Injury Severity Score (ISS) find increasingly widespread use to assess trauma burden and to perform interhospital benchmarking through trauma registries. Since 2015, public resource allocation in Switzerland shall even be derived from such data. As every trauma centre is responsible for its own coding and data input, this study aims at evaluating interobserver reliability of AIS and ISS coding. METHODS: Interobserver reliability of the AIS and ISS is analysed from a cohort of 50 consecutive severely injured patients treated in 2012 at our institution, coded retrospectively by 3 independent and specifically trained observers...
February 21, 2017: Injury
https://www.readbyqxmd.com/read/28259121/uncouplers-of-oxidation-and-phosphorylation-as-antiaging-compounds
#20
REVIEW
D A Knorre, F F Severin
Food restriction causes a set of physiological changes that reduce the rate of aging. At the level of an organism, these changes are initiated by a hormonal response, which in turn activates certain intracellular signaling cascades. As a result, cells increase their antioxidant capacities and decrease the risk of cancerous transformation. A number of small molecule compounds activating these signaling cascades have been described. One could expect that direct pharmacological activation of the signaling can produce a stronger antiaging effect than that achieved by the indirect hormonal stimulation...
December 2016: Biochemistry. Biokhimii︠a︡
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