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https://www.readbyqxmd.com/read/28813216/kinetics-of-zika-viral-load-in-semen
#1
LETTER
Franck de Laval, Séverine Matheus, Thomas Labrousse, Antoine Enfissi, Dominique Rousset, Sébastien Briolant
New England Journal of Medicine, Volume 377, Issue 7, Page 697-699, August 2017.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28810837/phase-i-dose-escalation-study-of-pazopanib-combined-with-bevacizumab-in-patients-with-metastatic-renal-cell-carcinoma-or-other-advanced-tumors
#2
Sylvie Négrier, David Pérol, Rastislav Bahleda, Antoine Hollebecque, Etienne Chatelut, Helen Boyle, Philippe Cassier, Séverine Metzger, Ellen Blanc, Jean-Charles Soria, Bernard Escudier
BACKGROUND: Vascular endothelial growth factor (VEGF) directed therapies are being used in a large number of advanced tumors. Metastatic renal cell carcinoma (mRCC) is highly dependent on the VEGF pathway; VEGF receptor (VEGFR) tyrosine kinase inhibitors (TKI) and humanized VEGF monoclonal antibody have been registered for clinical use in advanced renal cell carcinoma. The VEGFR TKI, pazopanib, with a rather manageable toxicity profile, was preferred to sunitinib by mRCC patients. We investigate the combination of pazopanib and bevacizumab to determine the maximum tolerated dose (MTD) in mRCC and other advanced solid tumors...
August 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28805401/the-common-sense-model-of-self-regulation-meta-analysis-and-test-of-a-process-model
#3
Martin S Hagger, Severine Koch, Nikos L D Chatzisarantis, Sheina Orbell
According to the common-sense model of self-regulation, individuals form lay representations of illnesses that guide coping procedures to manage illness threat. We meta-analyzed studies adopting the model to (a) examine the intercorrelations among illness representation dimensions, coping strategies, and illness outcomes; (b) test the sufficiency of a process model in which relations between illness representations and outcomes were mediated by coping strategies; and (c) test effects of moderators on model relations...
August 14, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28804864/prescription-and-indication-for-oral-nutritional-supplements-in-a-swiss-university-hospital-a-prospective-survey
#4
Julie Mareschal, Jean Altwegg, Dimitri Berthet, Marinette Chikhi, Pierre Chopard, Séverine Graf, Christian Sierro, Claude Pichard, Laurence Genton
AIMS OF THE STUDY: Patients with an acute or chronically negative nutritional balance are at nutritional risk. Oral nutritional supplements (ONS) are simple and effective medical treatments of nutritional risk. In the ambulatory setting, in Switzerland, ONS are reimbursed by public insurance under conditions defined by Swiss Society for Clinical Nutrition. The reimbursement requires a medical prescription for ONS and their delivery at the patient's home by a homecare service. The indication for the ONS, defined as a Nutritional Risk Screening-2002 (NRS-2002) score ≥3, must also be present...
August 14, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28803053/optimized-transitory-ectopic-expression-of-promastigote-surface-antigen-protein-in-nicotiana-benthamiana-a-potential-anti-leishmaniasis-vaccine-candidate
#5
Séverine Lacombe, Martine Bangratz, Jean-Paul Brizard, Elodie Petitdidier, Julie Pagniez, Drissa Sérémé, Jean-Loup Lemesre, Christophe Brugidou
In recent years, plants have been shown to be an efficient alternative expression system for high-value pharmaceuticals such as vaccines. However, constitutive expression of recombinant protein remains uncertain on their level of production and biological activity. To overcome these problems, transitory expression systems have been developed. Here, a series of experiments were performed to determine the most effective conditions to enhance vaccine antigen transient accumulation in Nicotiana benthamiana leaves using the promastigote surface antigen (PSA) from the parasitic protozoan Leishmania infantum...
August 10, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28802841/effects-of-symbiotic-status-on-cellular-immunity-dynamics-in-sitophilus-oryzae
#6
Sergio López-Madrigal, Justin Maire, Séverine Balmand, Anna Zaidman-Rémy, Abdelaziz Heddi
Many insects maintain intracellular symbiosis with mutualistic bacteria that improve their adaptive capabilities in nutritionally poor habitats. Adaptation of insect immune systems to such associations has been shown in several symbiotic consortia, including that of the rice weevil Sitophilus oryzae with the gammaproteobacterium Sodalis pierantonius. Although authors have mostly focused on the role of humoral immunity in host-symbiont interactions, recent studies suggest that symbiotic bacteria may also interfere with the cellular, hemocyte-based, immunity...
August 9, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28796631/endocrine-disruption-in-human-fetal-testis-explants-by-individual-and-combined-exposures-to-selected-pharmaceuticals-pesticides-and-environmental-pollutants
#7
Pierre Gaudriault, Séverine Mazaud-Guittot, Vincent Lavoué, Isabelle Coiffec, Laurianne Lesné, Nathalie Dejucq-Rainsford, Martin Scholze, Andreas Kortenkamp, Bernard Jégou
BACKGROUND: Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those of the most effective component in the mixture has not been studied directly in human tissues. Suppression of androgen synthesis in fetal life has been associated with testis maldescent, malformations of the genitalia at birth, and poor semen quality later in life. OBJECTIVES: Our aim was to investigate whether chemicals can act together to disrupt androgen production in human fetal testis explants and to evaluate the importance of mixture effects when characterizing the hazard of individual chemicals...
August 4, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28796511/unveiling-the-ionization-energy-of-the-cn-radical
#8
Bérenger Gans, Séverine Boyé-Péronne, Gustavo A Garcia, Anja Röder, Domenik Schleier, Philippe Halvick, Jean-Christophe Loison
The cyano radical is an ubiquitous molecule, and was for instance one of the first species detected in astrophysical media such as comets or diffuse clouds. In photodis- sociation regions the reaction rate of CN(+) + CO → CN + CO(+) is one of the critical parameters defining nitrile chemistry. The enthalpy of this charge transfer reaction is defined as the difference of ionization energies (EI) between CN and CO. Although EI(CO) is known accurately, the EI(CN) values are more dispersed and deduced indirectly from thermodynamic thresholds only, all above EI(CO), leading to the assumption that the reaction was fast even at low temperature...
August 10, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28795125/the-microbiome-activates-cd4-t-cell-mediated-immunity-to%C3%A2-compensate-for-increased-intestinal-permeability
#9
Karen L Edelblum, Gil Sharon, Gurminder Singh, Matthew A Odenwald, Anne Sailer, Severine Cao, Sarina Ravens, Irene Thomsen, Kamal El Bissati, Rima McLeod, Chen Dong, Sandeep Gurbuxani, Immo Prinz, Sarkis K Mazmanian, Jerrold R Turner
BACKGROUND & AIMS: Despite a prominent association, chronic intestinal barrier loss is insufficient to induce disease in human subjects or experimental animals. We hypothesized that compensatory mucosal immune activation might protect individuals with increased intestinal permeability from disease. We used a model in which intestinal barrier loss is triggered by intestinal epithelial-specific expression of constitutively active myosin light chain kinase (CA-MLCK). Here we asked whether constitutive tight junction barrier loss impacts susceptibility to enteric pathogens...
September 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28792952/everolimus-long-term-use-in-patients-with-tuberous-sclerosis-complex-four-year-update-of-the-exist-2-study
#10
John J Bissler, J Chris Kingswood, Elzbieta Radzikowska, Bernard A Zonnenberg, Elena Belousova, Michael D Frost, Matthias Sauter, Susanne Brakemeier, Petrus J de Vries, Noah Berkowitz, Maurizio Voi, Severine Peyrard, Klemens Budde
OBJECTIVES: We examined the long-term effects of everolimus in patients with renal angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis. METHODS: Following favorable results from the double-blind core phase of EXIST-2 (NCT00790400), patients were allowed to receive open-label everolimus (extension phase). Patients initially randomly assigned to everolimus continued on the same dose; those who were receiving placebo crossed over to everolimus 10 mg/day...
2017: PloS One
https://www.readbyqxmd.com/read/28791720/infectivity-in-bone-marrow-from-sporadic-cjd-patients
#11
Alvina Huor, Jean Yves Douet, Caroline Lacroux, Séverine Lugan, Cécile Tillier, Naima Aron, Hervé Cassard, Mark Arnold, Juan Maria Torres, James W Ironside, Olivier Andréoletti
Prion infectivity was recently identified in the blood of both sporadic and variant Creutzfeldt-Jakob disease (CJD) patients. In variant CJD (vCJD) the widespread distribution of prions in peripheral tissues of both asymptomatic and symptomatic patients is likely to explain the occurrence of the observed prionaemia. However, in sporadic CJD (sCJD) prion infectivity is described to be located principally in the central nervous system. In this study, we investigated the presence of prion infectivity in bone marrow collected after death in patients affected with different sCJD agents...
August 9, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28791256/in-vivo-host-pathogen-interaction-as-revealed-by-global-proteomic-profiling-of-zebrafish-larvae
#12
Francisco Díaz-Pascual, Javiera Ortíz-Severín, Macarena A Varas, Miguel L Allende, Francisco P Chávez
The outcome of a host-pathogen interaction is determined by the conditions of the host, the pathogen, and the environment. Although numerous proteomic studies of in vitro-grown microbial pathogens have been performed, in vivo proteomic approaches are still rare. In addition, increasing evidence supports that in vitro studies inadequately reflect in vivo conditions. Choosing the proper host is essential to detect the expression of proteins from the pathogen in vivo. Numerous studies have demonstrated the suitability of zebrafish (Danio rerio) embryos as a model to in vivo studies of Pseudomonas aeruginosa infection...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28790203/the-in-feed-antibiotic-carbadox-induces-phage-gene-transcription-in-the-swine-gut-microbiome
#13
Timothy A Johnson, Torey Looft, Andrew J Severin, Darrell O Bayles, Daniel J Nasko, K Eric Wommack, Adina Howe, Heather K Allen
Carbadox is a quinoxaline-di-N-oxide antibiotic fed to over 40% of young pigs in the United States that has been shown to induce phage DNA transduction in vitro; however, the effects of carbadox on swine microbiome functions are poorly understood. We investigated the in vivo longitudinal effects of carbadox on swine gut microbial gene expression (fecal metatranscriptome) and phage population dynamics (fecal dsDNA viromes). Microbial metagenome, transcriptome, and virome sequences were annotated for taxonomic inference and gene function by using FIGfam (isofunctional homolog sequences) and SEED subsystems databases...
August 8, 2017: MBio
https://www.readbyqxmd.com/read/28790147/hepatocyte-specific-deletion-of-egfr-in-mice-reduces-hepatic-abcg2-transport-activity-measured-with-11-c-erlotinib-and-positron-emission-tomography
#14
Alexander Traxl, Karin Komposch, Elisabeth Glitzner, Thomas Wanek, Severin Mairinger, Oliver Langer, Maria Sibilia
The epidermal growth factor receptor (EGFR) regulates cellular expression levels of breast cancer resistance protein (humans: ABCG2, rodents: Abcg2) via its downstream signaling pathways. Drugs that inhibit EGFR signaling (e.g. tyrosine kinase inhibitors, antibodies) may lead to ABCG2-mediated drug-drug interactions (DDIs) by changing disposition of concomitantly administered ABCG2 substrate drugs. In this study we used positron emission tomography (PET)/magnetic resonance (MR) imaging to compare disposition of the model Abcg2 substrate [(11)C]erlotinib in a mouse model of hepatocyte-specific deletion of EGFR (EGFR(Δhep) mice, n = 5) with EGFR(fl/fl) control mice (n = 6), which have normal EGFR expression levels in all tissues...
August 8, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28780744/advances-in-transgenic-animal-models-and-techniques
#15
Séverine Ménoret, Laurent Tesson, Séverine Remy, Claire Usal, Laure-Hélène Ouisse, Lucas Brusselle, Vanessa Chenouard, Ignacio Anegon
On May 11th and 12th 2017 was held in Nantes, France, the international meeting "Advances in transgenic animal models and techniques" ( http://www.trm.univ-nantes.fr/ ). This biennial meeting is the fifth one of its kind to be organized by the Transgenic Rats ImmunoPhenomic (TRIP) Nantes facility ( http://www.tgr.nantes.inserm.fr/ ). The meeting was supported by private companies (SONIDEL, Scionics computer innovation, New England Biolabs, MERCK, genOway, Journal Disease Models and Mechanisms) and by public institutions (International Society for Transgenic Technology, University of Nantes, INSERM UMR 1064, SFR François Bonamy, CNRS, Région Pays de la Loire, Biogenouest, TEFOR infrastructure, ITUN, IHU-CESTI and DHU-Oncogeffe and Labex IGO)...
August 5, 2017: Transgenic Research
https://www.readbyqxmd.com/read/28777824/shaping-visual-space-perception-through-bodily-sensations-testing-the-impact-of-nociceptive-stimuli-on-visual-perception-in-peripersonal-space-with-temporal-order-judgments
#16
Lieve Filbrich, Andrea Alamia, Séverine Blandiaux, Soline Burns, Valéry Legrain
Coordinating spatial perception between body space and its external surrounding space is essential to adapt behaviors to objects, especially when they are noxious. Such coherent multisensory representation of the body extended into external space is conceptualized by the notion of peripersonal reference frame, mapping the portion of space in which somatic and extra-somatic inputs interact closely. Studies on crossmodal interactions between nociception and vision have been scarce. Here we investigated how the perception of visual stimuli, especially those surrounding the body, can be impacted by a nociceptive and potentially harmful stimulus inflicted on a particular body part...
2017: PloS One
https://www.readbyqxmd.com/read/28771825/mercury-bioavailability-transformations-and-effects-to-freshwater-biofilms
#17
REVIEW
Perrine Dranguet, Séverine Le Faucheur, Vera I Slaveykova
Mercury (Hg) compounds represent an important risk to aquatic ecosystems due to their persistence, bioaccumulation and biomagnification potential. In the present review, we critically examine the state-of-the-art studies concerning the interactions of Hg compounds with freshwater biofilms with emphasis on Hg accumulation, transformations and effects. Freshwater biofilms contain both primary producers (e.g. algae) and decomposers (e.g bacteria and fungi), which contribute to both aquatic food webs and microbial loop...
August 3, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28771624/lc-ms-ms-versus-tlc-plus-gc-methods-consistency-of-glycerolipid-and-fatty-acid-profiles-in-microalgae-and-higher-plant-cells-and-effect-of-a-nitrogen-starvation
#18
Juliette Jouhet, Josselin Lupette, Olivier Clerc, Leonardo Magneschi, Mariette Bedhomme, Séverine Collin, Sylvaine Roy, Eric Maréchal, Fabrice Rébeillé
Methods to analyze lipidomes have considerably evolved, more and more based on mass spectrometry technics (LC-MS/MS). However, accurate quantifications using these methods require 13C-labeled standards for each lipid, which is not feasible because of the very large number of molecules. Thus, quantifications rely on standard molecules representative of a whole class of lipids, which might lead to false estimations of some molecular species. Here, we determined and compared glycerolipid distributions from three different types of cells, two microalgae (Phaeodactylum tricornutum, Nannochloropsis gaditana) and one higher plant (Arabidopsis thaliana), using either LC-MS/MS or Thin Layer Chromatography coupled with Gas Chromatography (TLC-GC), this last approach relying on the precise quantification of the fatty acids present in each glycerolipid class...
2017: PloS One
https://www.readbyqxmd.com/read/28767683/quantifying-kinematic-differences-between-land-and-water-during-squats-split-squats-and-single-leg-squats-in-a-healthy-population
#19
Anna C Severin, Brendan J Burkett, Mark R McKean, Aaron N Wiegand, Mark G L Sayers
Aquatic exercises can be used in clinical and sporting disciplines for both rehabilitation and sports training. However, there is limited knowledge on the influence of water immersion on the kinematics of exercises commonly used in rehabilitation and fitness programs. The aim of this study was to use inertial sensors to quantify differences in kinematics and movement variability of bodyweight squats, split squats, and single-leg squats performed on dry land and whilst immersed to the level of the greater trochanter...
2017: PloS One
https://www.readbyqxmd.com/read/28763706/variation-in-relative-water-content-proline-accumulation-and-stress-gene-expression-in-two-cowpea-landraces-under-drought
#20
Zahia Zegaoui, Séverine Planchais, Cécile Cabassa, Reda Djebbar, Ouzna Abrous Belbachir, Pierre Carol
Many landraces of cowpea [Vigna unguiculata (L.) Walp.] are adapted to particular geographical and climatic conditions. Here we describe two landraces grown respectively in arid and temperate areas of Algeria and assess their physiological and molecular responses to drought stress. As expected, when deprived of water cowpea plants lose water over time with a gradual reduction in transpiration rate. The landraces differed in their relative water content (RWC) and whole plant transpiration rate. The landrace from Menia, an arid area, retained more water in adult leaves...
July 14, 2017: Journal of Plant Physiology
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