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https://www.readbyqxmd.com/read/29163980/follow-up-monitoring-in-a-cat-with-leishmaniosis-and-coinfections-with-hepatozoon-felis-and-candidatus-mycoplasma-haemominutum
#1
Charalampos Attipa, Kyriaki Neofytou, Christos Yiapanis, Pamela Martínez-Orellana, Gad Baneth, Yaarit Nachum-Biala, Harriet Brooks-Brownlie, Laia Solano-Gallego, Séverine Tasker
Case summary: A 6-year-old female neutered domestic shorthair cat from Cyprus was presented with multiple ulcerated skin nodules. Cytology and histopathology of the lesions revealed granulomatous dermatitis with intracytoplasmic organisms, consistent with amastigotes of Leishmania species. Biochemistry identified a mild hyperproteinaemia. Blood extraction and PCR detected Leishmania species, Hepatozoon species and 'Candidatus Mycoplasma haemominutum' (CMhm) DNA. Subsequent sequencing identified Hepatozoon felis...
July 2017: JFMS open reports
https://www.readbyqxmd.com/read/29160593/xb-or-not-xb-that-is-the-question-the-interaction-modes-of-haloimidazolium-salts-in-solution
#2
Nils Schulz, Pandian Sokkar, Elric Engelage, Severin Schindler, Mate Erdelyi, Elsa Sanchez-Garcia, Stefan Matthias Huber
We performed a comparative study on the interaction mode of 2-haloimidazolium salts with anions in solution, particularly with regard to halogen bonding, hydrogen bonding and anion-π interactions. The syntheses and solid-state analyses of a series of sterically and electronically modified 2-haloimidazolium structures is presented. Detailed isothermal titration calorimetry (ITC) measurements, quantum mechanics/molecular mechanics (QM/MM MD), classical molecular dynamics simulations (MD) and free energy calculations together with NMR were used to elucidate the binding mode in solution...
November 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29157654/an-innovative-lung-model-for-multiple-breath-washout-testing-in-health-and-disease
#3
Pinelopi Anagnostopoulou, Sarah Vomsattel, Anne-Christiane Kentgens, Marisa Guidi, Severin Binggeli, Lena Kohler, Florian Singer, Philipp Latzin, Dominik Obrist
BACKGROUND: Multiple breath washout (MBW) is a lung function test that identifies the degree of ventilation inhomogeneity (VI) in the lungs. In vitro validation of MBW devices is recommended. So far, plastic lung models for MBW validation ignored variable degrees of VI. Our primary aim was to create a plastic lung model applicable for physiological lung volumes and variable VI. METHODS: A plastic box divided in two chambers was filled with water and ventilated in various lung volumes and respiratory rates...
November 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29154718/pesticide-residues-in-food-attitudes-beliefs-and-misconceptions-among-conventional-and-organic-consumers
#4
Severine Koch, Astrid Epp, Mark Lohmann, Gaby-Fleur Böl
Pesticide use and pesticide residues in foods have been the subject of controversial public discussions and media coverage in Germany. Against this background, a better understanding of public risk perceptions is needed to promote efficient public health communication. To this end, this study captures the German public's perception of pesticide residues in foods. A representative sample of the population aged 14 years and older (n = 1,004) was surveyed via computer-assisted telephone interviewing on their attitudes and knowledge with regard to pesticide residues...
November 20, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29152806/nanomorphology-effects-in-semiconductors-with-native-ferromagnetism-hierarchical-europium-ii-oxide-tubes-prepared-via-a-topotactic-nanostructure-transition
#5
Bastian Trepka, Philipp Erler, Severin Selzer, Tom Kollek, Klaus Boldt, Mikhail Fonin, Ulrich Nowak, Daniel Wolf, Axel Lubk, Sebastian Polarz
Semiconductors with native ferromagnetism barely exist and defined nanostructures are almost unknown. This lack impedes the exploration of a new class of materials characterized by a direct combination of effects on the electronic system caused by quantum confinement effects with magnetism. A good example is EuO for which currently no reliable routes for nanoparticle synthesis can be established. Bottom-up approaches applicable to other oxides fail because of the labile oxidation state +II. Instead of targeting a direct synthesis, the two steps-"structure control" and "chemical transformation"-are separated...
November 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29150804/using-citrus-aurantifolia-essential-oil-for-the-potential-biocontrol-of-colocasia-esculenta-taro-leaf-blight-caused-by-phytophthora-colocasiae
#6
Séverin Nguemezi Tchameni, Staelle Njamou Mbiakeu, Modeste Lambert Sameza, Pierre Michel Dongmo Jazet, François Tchoumbougnang
The aim of this work was to evaluate the antimicrobial activities of leaves and epicarp of Citrus aurantifolia essential oil against Phytophthora colocasiae, the causative agent of taro leaf blight. Oils were extracted by hydrodistillation, and their chemical composition was determined by gas chromatography and gas chromatography coupled with mass spectrometry. Antimicrobial activities of oils were tested in vitro against mycelium growth and sporangium production. In situ tests were done on healthy taro leaves, and the necrosis symptoms were evaluated...
November 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29149670/an-updated-review-on-tritium-in-the-environment
#7
REVIEW
Frédérique Eyrolle, Loïc Ducros, Séverine Le Dizès, Karine Beaugelin-Seiller, Sabine Charmasson, Patrick Boyer, Catherine Cossonnet
Various studies indicated more or less recently that organically bound tritium (OBT) formed from gaseous or liquid tritium releases into the environment potentially accumulates in organisms contradicting hypotheses associated to methods used to assess the biological impact of tritium on humans (ASN, 2010). Increasing research works were then performed during the last decade in order to gain knowledge on this radionuclide expected to be increasingly released by nuclear installations in the near future within the environment...
November 14, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29148428/-sup-135-sup-la-as-an-auger-electron-emitter-for-targeted-internal-radiotherapy
#8
Jesper Fonslet, Boon Quan Lee, Thuy A Tran, Mattia Siragusa, Mikael Jensen, Tibor Kibedi, Andrew E Stuchbery, Gregory W Severin
<b>Introduction:</b> <sup>135</sup>La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, imaging characteristics, and dosimetry related to <sup>135</sup>La therapy. <b>Methods and Results:</b> <sup>135</sup>La was produced by 16.5 MeV proton irradiation of metallic <sup>nat</sup>Ba on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin...
November 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29143816/quantitative-microbiome-profiling-links-gut-community-variation-to-microbial-load
#9
Doris Vandeputte, Gunter Kathagen, Kevin D'hoe, Sara Vieira-Silva, Mireia Valles-Colomer, João Sabino, Jun Wang, Raul Y Tito, Lindsey De Commer, Youssef Darzi, Séverine Vermeire, Gwen Falony, Jeroen Raes
Current sequencing-based analyses of faecal microbiota quantify microbial taxa and metabolic pathways as fractions of the sample sequence library generated by each analysis. Although these relative approaches permit detection of disease-associated microbiome variation, they are limited in their ability to reveal the interplay between microbiota and host health. Comparative analyses of relative microbiome data cannot provide information about the extent or directionality of changes in taxa abundance or metabolic potential...
November 15, 2017: Nature
https://www.readbyqxmd.com/read/29141261/-virtual-planning-of-prosthetic-treatment-of-the-orbit
#10
Johannes A Veit, Julia Thierauf, Kornelius Egner, Paul Severin Wiggenhauser, Daniel Friedrich, Jens Greve, Patrick J Schuler, Thomas K Hoffmann, Alexander Schramm
No abstract text is available yet for this article.
June 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29140943/antibodies-toward-vedolizumab-appear-from-the-first-infusion-onward-and-disappear-over-time
#11
Sumin Bian, Erwin Dreesen, Ho Tsun Tang, Griet Compernolle, Miet Peeters, Gert Van Assche, Marc Ferrante, Séverine Vermeire, Ann Gils
BACKGROUND: Vedolizumab (VDZ) has been approved for the treatment of patients with moderate-to-severe Crohn's disease and ulcerative colitis. The GEMINI trials reported a low prevalence of anti-VDZ antibodies (AVA). However, the AVA assays used in GEMINI were drug sensitive, resulting in a possible underestimation of the rate of AVA formation. This study aimed to monitor immunogenicity of VDZ in a real-life cohort using a drug-resistant AVA assay. METHODS: Using a combination of VDZ/AVA complex precipitation and acid dissociation, a drug-resistant assay for AVA detection in the presence of high VDZ concentrations has been developed and analytically validated...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29136149/pesticide-use-in-agriculture-and-parkinson-s-disease-in-the-agrican-cohort-study
#12
Camille Pouchieu, Clément Piel, Camille Carles, Anne Gruber, Catherine Helmer, Séverine Tual, Elisabeth Marcotullio, Pierre Lebailly, Isabelle Baldi
Background and Aim: Epidemiological studies have reported an increased risk of Parkinson's disease (PD) in farmers exposed to pesticides, but no clear conclusion can be drawn on the type of pesticide and duration of use associated with an effect. In the French agricultural cohort AGRICAN, we assessed associations between PD and pesticide use according to the types of livestock and crops grown, including exposure to some active ingredients with duration of use. Methods: Self-reported PD and history of lifetime exposure to 13 crops and 5 types of animals and pesticide use were collected at enrolment (2005-07) among 181 842 participants...
November 9, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29131862/optimized-approach-for-the-identification-of-highly-efficient-correctors-of-nonsense-mutations-in-human-diseases
#13
Hana Benhabiles, Sara Gonzalez-Hilarion, Séverine Amand, Christine Bailly, Anne Prévotat, Philippe Reix, Dominique Hubert, Eric Adriaenssens, Sylvie Rebuffat, David Tulasne, Fabrice Lejeune
About 10% of patients with a genetic disease carry a nonsense mutation causing their pathology. A strategy for correcting nonsense mutations is premature termination codon (PTC) readthrough, i.e. incorporation of an amino acid at the PTC position during translation. PTC-readthrough-activating molecules appear as promising therapeutic tools for these patients. Unfortunately, the molecules shown to induce PTC readthrough show low efficacy, probably because the mRNAs carrying a nonsense mutation are scarce, as they are also substrates of the quality control mechanism called nonsense-mediated mRNA decay (NMD)...
2017: PloS One
https://www.readbyqxmd.com/read/29127003/recombinant-alpha-fetoprotein-receptor-binding-domain-co-expression-with-polyglutamate-tags-facilitates-in-vivo-folding-in-e-coli
#14
Murad Mollaev, Neonila Gorokhovets, Elena Nikolskaya, Maria Faustova, Arthur Zabolotsky, Maria Sokol, Oksana Tereshenko, Olga Zhunina, Vitaliy Shvets, Evgeniy Severin, Nikita Yabbarov
A wide range of methods are known to increase the prokaryotic intracellular recombinant proteins solubility, for instance, growth at low temperature, supplementation of culture media with "chemical chaperones" (proline, glycine-betaine, and trehalose), co-expression with chaperones or highly soluble fusion partners. As an alternative, we have introduced the polyglutamate tag, which, as it has been shown, increased the protein solubility and facilitated folding. In this study we evaluated the minimal quantity of high density negatively charged EEEEVE amino acid repeats (pGlu) necessary to switch the recombinant receptor-binding domain of human alpha-fetoprotein (rbdAFP) expression almost entirely from the inclusion bodies to the soluble cytoplasmic fraction in E...
November 7, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/29124834/prevalence-and-characterization-of-staphylococcus-aureus-causing-community-acquired-skin-and-soft-tissue-infections-on-java-and-bali-indonesia
#15
Dewi Santosaningsih, Sanarto Santoso, Nanik Setijowati, Harun A Rasyid, Nyoman S Budayanti, Ketut Suata, Dicky B Widhyatmoko, Priyo B Purwono, Kuntaman Kuntaman, Damayanti Damayanti, Cita R S Prakoeswa, Mitchell Laurens, Josephine W I van Nierop, Geraldine L Nanninga, Neline Oudenes, Michelle de Regt, Susan V Snijders, Henri A Verbrugh, Juliëtte A Severin
OBJECTIVES: To define the role of Staphylococcus aureus in community settings among patients with skin and soft tissue infections (SSTI) in Indonesia. METHODS: S. aureus were cultured from anterior nares, throat, and wounds of 567 ambulatory patients presenting with SSTI. The mecA gene and genes encoding Panton-Valentine leukocidin (PVL; lukF-PV and lukS-PV) and exfoliative toxin (ET; eta and etb) were determined by PCR. Clonal relatedness among methicillin-resistant S...
November 10, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29122662/remote-loading-of-liposomes-with-manganese-52-and-in-vivo-evaluation-of-the-stabilities-of-52-mn-dota-and-64-cu-dota-using-radiolabelled-liposomes-and-pet-imaging
#16
Andreas I Jensen, Gregory W Severin, Anders E Hansen, Frederikke P Fliedner, Rasmus Eliasen, Ladan Parhamifar, Andreas Kjær, Thomas L Andresen, Jonas R Henriksen
Liposomes are nanoparticles used in drug delivery that distribute over several days in humans and larger animals. Radiolabeling with long-lived positron emission tomography (PET) radionuclides, such as manganese-52 ((52)Mn, T½=5.6days), allow the imaging of this biodistribution. We report optimized protocols for radiolabeling liposomes with (52)Mn, through both remote-loading and surface labeling. For comparison, liposomes were also remote-loaded and surface labeled with copper-64 ((64)Cu, T½=12.7h) through conventional means...
November 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29116540/long-term-safety-of-long-acting-octreotide-in-patients-with-diabetic-retinopathy-results-of-pooled-data-from-2-randomized-double-blind-placebo-controlled-phase-3-studies
#17
Rosario Pivonello, Giovanna Muscogiuri, Geoffrey Holder, Michaela Paul, Severine Sarp, Anastasia Lesogor, Pierre Jordaan, Johannes Eisinger, Annamaria Colao
PURPOSE: Octreotide (OCT) has been successfully used for treatment of acromegaly and neuroendocrine tumors for more than 30 years. However, long-term safety of OCT has not been documented in placebo-controlled setting. This present analysis pooled safety data from two similarly-designed, randomized, and placebo-controlled studies to evaluate long-term safety of long-acting OCT (20, 30 mg); targeted post-hoc analyzes focused on cardiac, hepatic, and renal safety. METHODS: Two studies (NCT00131144, NCT001308450) were conducted in patients with diabetic retinopathy (OCT20 = 191, OCT30 = 348, placebo = 347)...
November 7, 2017: Endocrine
https://www.readbyqxmd.com/read/29114386/suppression-of-inflammation-and-tissue-damage-by-a-hookworm-recombinant-protein-in-experimental-colitis
#18
Ivana B Ferreira, Darren A Pickering, Sally Troy, John Croese, Alex Loukas, Severine Navarro
Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an immunoregulatory environment that promotes their own survival, but paradoxically also benefits the host by protecting against the onset of many inflammatory diseases. To harness the therapeutic value of hookworms without using live parasites, we have examined the protective properties of the recombinant protein anti-inflammatory protein (AIP)-1, secreted in abundance by hookworms within the intestinal mucosa, in experimental colitis...
October 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29113731/oral-fexinidazole-for-late-stage-african-trypanosoma-brucei-gambiense-trypanosomiasis-a-pivotal-multicentre-randomised-non-inferiority-trial
#19
Victor Kande Betu Ku Mesu, Wilfried Mutombo Kalonji, Clélia Bardonneau, Olaf Valverde Mordt, Séverine Blesson, François Simon, Sophie Delhomme, Sonja Bernhard, Willy Kuziena, Jean-Pierre Fina Lubaki, Steven Lumeya Vuvu, Pathou Nganzobo Ngima, Hélène Mahenzi Mbembo, Médard Ilunga, Augustin Kasongo Bonama, Josué Amici Heradi, Jean Louis Lumaliza Solomo, Guylain Mandula, Lewis Kaninda Badibabi, Francis Regongbenga Dama, Papy Kavunga Lukula, Digas Ngolo Tete, Crispin Lumbala, Bruno Scherrer, Nathalie Strub-Wourgaft, Antoine Tarral
BACKGROUND: Few therapeutic options are available to treat late-stage human African trypanosomiasis, a neglected tropical disease caused by Trypanosoma brucei gambiense (g-HAT). The firstline treatment nifurtimox eflornithine combination therapy needs to be administered intravenously in a hospital setting by trained personnel, which is not optimal, given that patients often live in remote areas with few health resources. Therefore, we aimed to assess the safety and efficacy of an oral regimen of fexinidazole (a 2-substituted 5-nitroimidazole with proven trypanocidal activity) versus nifurtimox eflornithine combination therapy in patients with late-stage g-HAT...
November 3, 2017: Lancet
https://www.readbyqxmd.com/read/29113627/the-proportion-of-asymptomatic-infections-and-spectrum-of-disease-among-pregnant-women-infected-by-zika-virus-systematic-monitoring-in-french-guiana-2016
#20
Claude Flamand, Camille Fritzell, Séverine Matheus, Maryvonne Dueymes, Gabriel Carles, Anne Favre, Antoine Enfissi, Antoine Adde, Magalie Demar, Mirdad Kazanji, Simon Cauchemez, Dominique Rousset
Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnancies in the territory were monitored by RT-PCR and/or detection of ZIKV antibodies. Follow-up data collected during pregnancy monitoring interviews were analysed from 1 February to 1 June 2016. We enrolled 3,050 pregnant women aged 14-48 years and 573 (19%) had laboratory-confirmed ZIKV infection...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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