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https://www.readbyqxmd.com/read/29775114/oxygen-dependency-of-mitochondrial-metabolism-indicates-outcome-of-newborn-brain-injury
#1
Gemma Bale, Subhabrata Mitra, Isabel de Roever, Magdalena Sokolska, David Price, Alan Bainbridge, Roxana Gunny, Cristina Uria-Avellanal, Giles S Kendall, Judith Meek, Nicola J Robertson, Ilias Tachtsidis
There is a need for a method of real-time assessment of brain metabolism during neonatal hypoxic-ischaemic encephalopathy (HIE). We have used broadband near-infrared spectroscopy (NIRS) to monitor cerebral oxygenation and metabolic changes in 50 neonates with HIE undergoing therapeutic hypothermia treatment. In 24 neonates, 54 episodes of spontaneous decreases in peripheral oxygen saturation (desaturations) were recorded between 6 and 81 h after birth. We observed differences in the cerebral metabolic responses to these episodes that were related to the predicted outcome of the injury, as determined by subsequent magnetic resonance spectroscopy derived lactate/N-acetyl-aspartate...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29769049/sleep-disordered-breathing-in-patients-with-newly-diagnosed-lung-cancer
#2
Michael Dreher, Stefan Krüger, Susanne Schulze-Olden, András Keszei, Jan Hendrik Storre, Holger Woehrle, Michael Arzt, Tobias Müller
BACKGROUND: There are currently no data on the prevalence of sleep-disordered breathing (SDB) in patients with newly-diagnosed lung cancer. This might be of interest given that SDB is associated with increased cancer incidence and mortality. Furthermore, intermittent hypoxia has been linked with tumor growth and progression. The aim of the current study was to investigate the prevalence of SDB in patients with newly-diagnosed lung cancer. METHODS: Patients with newly-diagnosed lung cancer from three centers in Germany were screened for SDB using a two-channel screening system (ApneaLink™)...
May 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29767787/sleep-disordered-breathing-in-c57bl-6j-mice-with-diet-induced-obesity
#3
Thomaz Fleury Curado, Huy Pho, Slava Berger, Candela Caballero-Eraso, Mi-Kyung Shin, Luiz Ubirajara Sennes, Luu Pham, Alan R Schwartz, Vsevolod Y Polotsky
Obesity leads to sleep disordered breathing (SDB), as manifested by recurrent upper airway obstructions during sleep termed obstructive sleep apnea and carbon dioxide retention due to obesity hypoventilation. The objective of this work was to characterize breathing during sleep in C57BL6/J mice with diet-induced obesity. Arterial blood gas was measured in nine obese and nine lean mice during wakefulness. Nine male mice with diet induced obesity and six lean male C57BL/6J mice were head mounted with EEG and EMG electrodes...
May 15, 2018: Sleep
https://www.readbyqxmd.com/read/29766410/complete-concentric-collapse-at-the-soft-palate-in-sleep-endoscopy-what-change-is-possible-after-uppp-in-patients-with-cpap-failure
#4
Katrin Hasselbacher, A Seitz, N Abrams, B Wollenberg, A Steffen
PURPOSE: The aim of this work was to assess whether uvulopalatopharyngoplasty in patients with failure for positive airway pressure not only reduces the degree of obstructive sleep apnea but also to determine as well if it changes the collapse pattern of the soft palate and thereby fulfills the qualifications for implementing upper airway stimulation (UAS) as an adjunctive solution. METHOD: Fifteen patients with intolerance for positive airway pressure were included in this retrospective cohort study...
May 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29765510/correlation-between-metabolic-syndrome-and-sleep-apnea
#5
REVIEW
Alejandro Castaneda, Edgar Jauregui-Maldonado, Iqbal Ratnani, Joseph Varon, Salim Surani
The so-called "metabolic syndrome" (MS), constitutes a cluster of metabolic and cardiovascular abnormalities, including fasting glucose, blood pressure, triglycerides, high density lipoprotein cholesterol (HDL-C), and waist circumference that arise from insulin resistance. Obstructive sleep apnea (OSA) syndrome is characterized by recurrent episodes of partial or complete obstruction of the upper airway, involving cessation or significant decreased airflow, with intermittent hypoxemia, frequent arousals from sleep and recurrent oxyhemoglobin desaturations that interfere with normal sleep patterns generating difficulty falling asleep, unrefreshing sleep and loud snoring...
April 15, 2018: World Journal of Diabetes
https://www.readbyqxmd.com/read/29762755/obstructive-sleep-apnea-during-rem-sleep-is-associated-with-early-signs-of-atherosclerosis-in-women
#6
Mirjam Ljunggren, Eva Lindberg, Karl A Franklin, Patrik Öhagen, Marita Larsson, Jenny Theorell-Haglöw, Tord Naessén
Study Objectives: While obstructive sleep apnea (OSA) is associated with overall cardiovascular disease and mortality, the association with atherosclerotic cardiovascular disease is less clear, especially in women. Recently, it has been suggested that OSA during REM sleep, associated with long apneas and deep desaturations, could have severe cardio-metabolic consequences. The aim of this study was to investigate whether OSA during REM sleep is associated with early signs of atherosclerosis in a population-based sample of women...
May 14, 2018: Sleep
https://www.readbyqxmd.com/read/29760773/high-oleate-yeast-oil-without-polyunsaturated-fatty-acids
#7
Vasiliki Tsakraklides, Annapurna Kamineni, Andrew L Consiglio, Kyle MacEwen, Jonathan Friedlander, Hannah G Blitzblau, Maureen A Hamilton, Donald V Crabtree, Austin Su, Jonathan Afshar, John E Sullivan, W Greg LaTouf, Colin R South, Emily H Greenhagen, A Joe Shaw, Elena E Brevnova
Background: Oleate-enriched triacylglycerides are well-suited for lubricant applications that require high oxidative stability. Fatty acid carbon chain length and degree of desaturation are key determinants of triacylglyceride properties and the ability to manipulate fatty acid composition in living organisms is critical to developing a source of bio-based oil tailored to meet specific application requirements. Results: We sought to engineer the oleaginous yeast Yarrowia lipolytica for production of high-oleate triacylglyceride oil...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29760010/home-oximetry-to-screen-for-obstructive-sleep-apnoea-in-down-syndrome
#8
Catherine M Hill, Heather E Elphick, Michael Farquhar, Paul Gringras, Ruth M Pickering, Ruth N Kingshott, Jane Martin, Janine Reynolds, Anna Joyce, Johanna C Gavlak, Hazel J Evans
OBJECTIVE: Children with Down syndrome are at high risk of obstructive sleep apnoea (OSA) and screening is recommended. Diagnosis of OSA should be confirmed with multichannel sleep studies. We aimed to determine whether home pulse oximetry (HPO) discriminates children at high risk of OSA, who need further diagnostic multichannel sleep studies. DESIGN: Cross-sectional prospective study in a training sample recruited through three UK centres. Validation sample used single-centre retrospective analysis of clinical data...
May 14, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29756744/monitoring-the-oxygen-reserve-index-can-contribute-to-the-early-detection-of-deterioration-in-blood-oxygenation-during-one-lung-ventilation
#9
Wakana Koishi, Motoi Kumagai, Shohei Ogawa, Shuhei Hongo, Kenji Suzuki
BACKGROUND: Hypoxemia can occur during one-lung ventilation (OLV), but monitoring blood oxygenation using percutaneous oxygen saturation (SpO2) can be limited by detection latency, and SpO2 sometimes does not change during OLV. The Oxygen Reserve Index (ORiTM) is a novel index reported to detect impending desaturation before this is observed with SpO2 monitoring. This study assessed whether the ORi decreased earlier than SpO2 during OLV and evaluated its correlation with the partial pressure of arterial oxygen (PaO2) during OLV...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29755518/double-barrel-nasal-trumpets-to-prevent-upper-airway-obstruction-after-nasal-and-non-nasal-surgery
#10
Macario Camacho, Justin M Wei, Lauren K Reckley, Sungjin A Song
Objectives: During anesthesia emergence, patients are extubated and the upper airway can become vulnerable to obstruction. Nasal trumpets can help prevent obstruction. However, we have found no manuscript describing how to place nasal trumpets after nasal surgery (septoplasties or septorhinoplasties), likely because (1) the lack of space with nasal splints in place and (2) surgeons may fear that removing the trumpets could displace the splints. The objective of this manuscript is to describe how to place nasal trumpets even with nasal splints in place...
2018: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/29755400/intermittent-hypoxia-is-associated-with-high-hypoxia-inducible-factor-1%C3%AE-but-not-high-vascular-endothelial-growth-factor-cell-expression-in-tumors-of-cutaneous-melanoma-patients
#11
Isaac Almendros, Miguel Ángel Martínez-García, Francisco Campos-Rodríguez, Erica Riveiro-Falkenbach, José L Rodríguez-Peralto, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernández Blasco, Jose Bañuls Roca, Eusebi Chiner Vives, Alicia Sánchez-de-la-Torre, Jorge Abad-Capa, Josep Maria Montserrat, Amalia Pérez-Gil, Valentín Cabriada-Nuño, Irene Cano-Pumarega, Jaime Corral-Peñafiel, Trinidad Diaz-Cambriles, Olga Mediano, Joan Dalmau-Arias, Ramon Farré, David Gozal
Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in the tumor and altered immune functions via intermittent hypoxia (IH). Here, we examined relationships between HIF-1α and VEGF expression and nocturnal IH in cutaneous melanoma (CM) tumor samples...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29754874/preoperative-screening-for-obstructive-sleep-apnea-and-outcomes-in-pacu
#12
Jill Setaro, Ruth Reinsel, Dana Brun
PURPOSE: Practice guidelines from the perianesthesia community suggest that preoperative identification of patients with obstructive sleep apnea (OSA) and standardized longer observation in postanesthesia care unit (PACU) promotes safety after general anesthesia. The purpose of this study was to determine if longer monitoring of patients with OSA in the PACU improves patient outcomes after general anesthesia. DESIGN: Evidence-based best practices literature review...
May 10, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29753853/chloral-hydrate-administered-by-a-dedicated-sedation-service-can-be-used-safely-and-effectively-for-pediatric-ophthalmic-examination
#13
Mohammed Karaoui, Varshini Varadaraj, Beatriz Munoz, Megan E Collins, Leyla Al Djasim, Esam Al Naji, Karam Hamweyah, Mohammed Al Shamrani, Earl Randy Craven, David S Friedman
PURPOSE: To determine safety and efficacy of oral chloral hydrate sedation (CHS) for outpatient pediatric ophthalmic procedures. DESIGN: Prospective, interventional case series METHODS-SETTING: - King Khaled Eye Specialist Hospital. SUBJECTS: Children ages 1 month to 5 years undergoing CHS for ocular imaging/evaluation PROCEDURES: Details on chloral hydrate dose administered, sedation achieved, vitals, and adverse events were recorded OUTCOME MEASURES: Primary Outcome: Percent of patients with a sedation level ≥4 at 45 minutes post chloral hydrate administration...
May 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29753601/crispr-cas9-mediated-genome-editing-of-the-fatty-acid-desaturase-2-gene-in-brassica-napus
#14
Ayako Okuzaki, Takumi Ogawa, Chie Koizuka, Kanako Kaneko, Mizue Inaba, Jun Imamura, Nobuya Koizuka
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9-mediated genome editing system has been widely applied as a powerful tool for modifying preferable endogenous genes. This system is highly expected to be further applied for the breeding of various agronomically important plant species. Here we report the modification of a fatty acid desaturase 2 gene (FAD2), which encodes an enzyme that catalyzes the desaturation of oleic acid, in Brassica napus cv. Westar using the CRISPR/Cas9 system...
April 26, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29750696/patient-controlled-versus-clinician-controlled-sedation-with-propofol-systematic-review-and-meta-analysis-with-trial-sequential-analyses
#15
Lukas Kreienbühl, Nadia Elia, Elvire Pfeil-Beun, Bernhard Walder, Martin R Tramèr
BACKGROUND: Sedation with propofol is frequently used to facilitate diagnostic and therapeutic procedures. Propofol can be administrated by the patient (patient-controlled sedation [PCS]) or by a clinician (clinician-controlled sedation [CCS]). We aimed to compare these 2 techniques. METHODS: PubMed, Embase, CENTRAL, and trial registries were searched up to October 2017 for randomized controlled trials comparing PCS with CCS with propofol. The primary end points were the risks of presenting at least 1 episode of oxygen desaturation, arterial hypotension, and bradycardia, and the risk of requiring a rescue intervention (pharmacologic therapies or physical maneuvers) for sedation-related adverse events...
May 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29750694/impact-of-2-distinct-levels-of-mean-arterial-pressure-on-near-infrared-spectroscopy-during-cardiac-surgery-secondary-outcome-from-a-randomized-clinical-trial
#16
Frederik Holmgaard, Anne G Vedel, Theis Lange, Jens C Nilsson, Hanne B Ravn
BACKGROUND: Near-infrared spectroscopy (NIRS) is used worldwide to monitor regional cerebral oxygenation (rScO2) during cardiopulmonary bypass (CPB). Intervention protocols meant to mitigate cerebral desaturation advocate to increase mean arterial pressure (MAP) when cerebral desaturation occurs. However, the isolated effect of MAP on rScO2 is uncertain. The aim of the present study was in a randomized, blinded design to elucidate the effect of 2 distinct levels of MAP on rScO2 values during CPB...
May 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29747936/pulmonary-screening-in-subjects-after-the-fontan-procedure
#17
Deborah R Liptzin, Michael V Di Maria, Adel Younoszai, Michael R Narkewicz, Sarah L Kelly, Kelly R Wolfe, Livia A Veress
OBJECTIVES: To review the pulmonary findings of the first 51 patients who presented to our interdisciplinary single-ventricle clinic after undergoing the Fontan procedure. STUDY DESIGN: We performed an Institutional Review Board-approved retrospective review of 51 patients evaluated following the Fontan procedure. Evaluation included history, physical examination, pulmonary function testing, and 6-minute walk. Descriptive statistics were used to describe the population and testing data...
May 7, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29746662/impact-of-sleep-characteristics-and-obesity-on-diabetes-and-hypertension-across-genders-and-menopausal-status-the-nagahama-study
#18
Takeshi Matsumoto, Kimihiko Murase, Yasuharu Tabara, David Gozal, Dale Smith, Takuma Minami, Ryo Tachikawa, Kiminobu Tanizawa, Toru Oga, Shunsuke Nagashima, Tomoko Wakamura, Naoko Komenami, Kazuya Setoh, Takahisa Kawaguchi, Takanobu Tsutsumi, Yoshimitsu Takahashi, Takeo Nakayama, Toyohiro Hirai, Fumihiko Matsuda, Kazuo Chin
Study Objectives: The individual prevalence of sleep-disordered breathing (SDB), short sleep duration, and obesity is high and increasing. The study aimed to investigate potential associations between SDB, objective sleep duration, obesity, diabetes and hypertension across genders, and the effect of pre- or post-menopausal status. Methods: A cross-sectional study evaluated 7051 community participants with wrist actigraphy for a week, and nocturnal oximetry ≥ 2 nights...
May 9, 2018: Sleep
https://www.readbyqxmd.com/read/29746617/a-wake-up-call-for-human-immunodeficiency-virus-hiv-providers-obstructive-sleep-apnea-in-people-living-with-hiv
#19
Robert L Owens, Charles B Hicks
Obstructive sleep apnea (OSA) is defined by repetitive collapse of the upper airway during sleep leading to transient hypoxemia and arousals from sleep. Surges in sympathetic activity, repeated oxygen desaturation, and sleep fragmentation can lead to cardiovascular (eg, myocardial infarction) and neurocognitive (eg, excessive daytime sleepiness) consequences. Emerging data suggest that OSA is common in people living with human immunodeficiency virus (PLWH) and that traditional risk factors for OSA, such as obesity, are not highly predictive of OSA in PLWH...
May 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29744301/intermittent-hypoxia-induced-epiregulin-expression-by-il-6-production-in-human-coronary-artery-smooth-muscle-cells
#20
Yoji Kyotani, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Mai Makino, Shin Takasawa, Masanori Yoshizumi
Patients with obstructive sleep apnea (OSA) experience repetitive episodes of desaturation and resaturation of blood oxygen (known as intermittent hypoxia or IH), during sleep. We showed previously that IH induced excessive proliferation of rat vascular smooth muscle cells through upregulation of members of the epidermal growth factor family, especially epiregulin (EREG), and the erbB2 receptor. In this study, we exposed human coronary artery smooth muscle cells to IH and found that IH significantly increased the expression of EREG...
May 2018: FEBS Open Bio
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