keyword
https://read.qxmd.com/read/34684442/monitored-supplementation-of-vitamin-d-in-preterm-infants-a-randomized-controlled-trial
#21
RANDOMIZED CONTROLLED TRIAL
Alicja Kołodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka
Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7-32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy ( n = 55; approximately 800-1000 IU from combined sources) or monitored therapy ( n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA)...
September 28, 2021: Nutrients
https://read.qxmd.com/read/34511163/expert-consensus-on-clinical-management-of-metabolic-bone-disease-of-prematurity-2021
#22
JOURNAL ARTICLE
Chang Yan-Mei, Lin Xin-Zhu, Zhang Rong, Liu Xi-Hong, Tong Xiao-Mei, Chen Ping-Yang, Feng Zhi-Chun
Metabolic bone disease of prematurity (MBDP) is a systemic bone disease with a reduction in bone mineral content due to disorder of calcium and phosphorus metabolism. There is still a lack of in-depth research and systematic understanding of MBDP in China, and there are many irregularities in clinical management of this disease. Based on relevant studies in China and overseas, Grading of Recommendations Assessment, Development and Evaluation was used to develop the expert consensus on the clinical management of MBDP, which provides recommendations from the following five aspects: high-risk factors, screening/diagnosis, prevention, treatment, and post-discharge follow-up of MBDP, so as to provide relevant practitioners with recommendations on the clinical management of MBDP to reduce the incidence rate of MBDP and improve its short- and long-term prognosis...
August 15, 2021: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/34489134/vitamin-d-and-bone-minerals-in-neonates
#23
JOURNAL ARTICLE
Steven A Abrams
Osteopenia and rickets remain a problem for high-risk infants, especially preterm infants <1500 g birthweight (very low birth weight, VLBW). The primary cause of osteopenia in VLBW infants is a low intake of calcium and phosphorus compared to requirements for the rapidly growing skeleton. Human milk is a relatively low mineral containing substance and cannot meet the bone mineral needs of very low birth weight infants. As such, most VLBW infants need additional bone minerals and in many neonatal care units these are provided as part of human milk fortificants or specialized infant formulas...
November 2021: Early Human Development
https://read.qxmd.com/read/34438555/physical-therapy-to-prevent-osteopenia-in-preterm-infants-a-systematic-review
#24
REVIEW
Galaad Torró-Ferrero, Francisco Javier Fernández-Rego, Antonia Gómez-Conesa
BACKGROUND: During the last trimester of pregnancy, about 80% of the infant's calcium is incorporated, and for this reason, preterm infants have less bone mineralization compared to those born at term. The aim of the present systematic review was to identify, evaluate and summarize the studies that deal with the effect of physiotherapy modalities in the prevention and treatment of osteopenia in preterm infants. METHODS: A comprehensive search (09/2019-02/2021) using PubMed, Web of Science, SCOPUS, ProQuest, SciELO, Latindex, ScienceDirect, PEDro and ClinicalTrials...
July 30, 2021: Children
https://read.qxmd.com/read/34374422/klotho-and-calciprotein-particles-as-therapeutic-targets-against-accelerated-ageing
#25
JOURNAL ARTICLE
Makoto Kuro-O
The klotho gene, named after a Greek goddess who spins the thread of life, was identified as a putative 'ageing-suppressor' gene. Klotho-deficient mice exhibit complex ageing-like phenotypes including hypogonadism, arteriosclerosis (vascular calcification), cardiac hypertrophy, osteopenia, sarcopenia, frailty, and premature death. Klotho protein functions as the obligate co-receptor for fibroblast growth factor-23 (FGF23), a bone-derived hormone that promotes urinary phosphate excretion in response to phosphate intake...
August 13, 2021: Clinical Science (1979-)
https://read.qxmd.com/read/34341698/premature-senescence-of-t-cells-favors-bone-loss-during-osteolytic-diseases-a-new-concern-in-the-osteoimmunology-arena
#26
JOURNAL ARTICLE
Luis González-Osuna, Alfredo Sierra-Cristancho, Carolina Rojas, Emilio A Cafferata, Samanta Melgar-Rodríguez, Angélica M Cárdenas, Rolando Vernal
Cellular senescence is a biological process triggered in response to time-accumulated DNA damage, which prioritizes cell survival over cell function. Particularly, senescent T lymphocytes can be generated prematurely during chronic inflammatory diseases regardless of chronological aging. These senescent T lymphocytes are characterized by the loss of CD28 expression, a co-stimulatory receptor that mediates antigen presentation and effective T-cell activation. An increased number of premature senescent CD4+ CD28- T lymphocytes has been frequently observed in osteolytic diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, osteopenia, osteoporosis, and osteomyelitis...
August 2021: Aging and Disease
https://read.qxmd.com/read/33973278/mir-4286-functions-in-osteogenesis-and-angiogenesis-via-targeting-histone-deacetylase-3-and-alleviates-alcohol-induced-bone-loss-in-mice
#27
JOURNAL ARTICLE
Hongping Yu, Kaiyang Wang, Pei Liu, Pengbo Luo, Daoyu Zhu, Junhui Yin, Qianhao Yang, Yigang Huang, Junjie Gao, Zisheng Ai, Yixuan Chen, Youshui Gao
OBJECTIVES: Alcohol consumption is one of the leading factors contributing to premature osteopenia. MicroRNA (miRNA) coordinates a cascade of anabolic and catabolic processes in bone homeostasis and dynamic vascularization. The aim was to investigate the protective role of miR-4286 in alcohol-induced bone loss and its mechanism. MATERIALS AND METHODS: The effect of miR-4286 and alcohol on bone mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs) was explored via multiple in vitro assays, including cell proliferation, QPCR, Western blot, osteogenesis, angiogenesis etc miR-4286 directly regulated HDAC3 was investigated by luciferase reporter assay, and the function of HDAC3 was also explored in vitro...
June 2021: Cell Proliferation
https://read.qxmd.com/read/33950963/the-incidence-of-osteopenia-of-prematurity-in-preterm-infants-without-phosphate-supplementation-a-prospective-observational-study
#28
JOURNAL ARTICLE
Dina Angelika, I Dewa Gede Ugrasena, Risa Etika, Paulus Rahardjo, Arend F Bos, Pieter J J Sauer
To meet their requirements for bone mineralization, it is recommended that preterm infants receive nutritional support containing calcium and phosphate. There are no clear data on the incidence of osteopenia of prematurity (OFP) in preterm infants without phosphate supplementation.This study aimed to investigate the incidence of OFP in preterm infants without phosphate supplementation and its relationship with the duration of parenteral nutrition (PN).This was a prospective and observational study.This study included 30 infants aged <32 gestational weeks and weighed <1500 g at birth...
May 7, 2021: Medicine (Baltimore)
https://read.qxmd.com/read/33868677/associated-neonatal-and-maternal-factors-of-osteopenia-of-prematurity-in-low-resource-setting-a-cross-sectional-study
#29
JOURNAL ARTICLE
Dina Angelika, Risa Etika, Muhammad Pradhika Mapindra, Martono Tri Utomo, Paulus Rahardjo, I Dewa Gede Ugrasena
OBJECTIVE: Determining neonatal and maternal factors that are associated with the incidence of OFP. METHODS: This study employed a cross-sectional design, in which the participants were identified for clinical variables (sex, gestational age, birth weight, etc.), neonatal morbidity (sepsis, necrotizing enterocolitis (NEC), etc.), and maternal risk factors (premature rupture of membranes, preeclampsia, etc.). The data were analyzed using Chi-square test, independent t -test, and logistic regression test with p < 0...
April 2021: Annals of Medicine and Surgery
https://read.qxmd.com/read/33559685/musculoskeletal-imaging-manifestations-of-beta-thalassemia
#30
REVIEW
Maryam Hajimoradi, Sara Haseli, Alireza Abadi, Majid Chalian
Beta-thalassemia is a heterogeneous group of anemic disorders caused by the absence or defective production of beta-globin chains. Their clinical manifestations vary from asymptomatic to severe symptoms leading to a transfusion-dependent anemic state. The genes that cause thalassemia are prevalent in Asian and African populations, particularly concentrated in the Middle East, Mediterranean region, parts of India, and South East Asia. Over time, the disease causes various musculoskeletal abnormalities with complex pathophysiology secondary to chronic anemia...
September 2021: Skeletal Radiology
https://read.qxmd.com/read/33436310/three-year-follow-up-of-bone-status-in-male-patients-after-bariatric-surgery-a-prospective-single-center-cohort-study
#31
JOURNAL ARTICLE
Daniëlle Susan Bonouvrie, Hans de Boer, Edo O Aarts
BACKGROUND: In women, bariatric surgery (BS) leads to a decline in bone mineral density (BMD) and may ultimately lead to premature osteoporosis. The impact in men is largely unknown. OBJECTIVE: To assess the effect of BS on bone metabolism in males. SETTING: Single-center prospective cohort study. METHODS: Twenty-four male BS candidates were prospectively enrolled. Anthropometric characteristics, serum gonadal hormones, markers of bone metabolism, and BMD were measured at baseline, 6-, 12- and 36-months postoperatively...
April 2021: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/33367459/non-pharmacological-interventions-in-osteosarcopenia-a-systematic-review
#32
JOURNAL ARTICLE
R Atlihan, B Kirk, G Duque
BACKGROUND: Osteosarcopenia is a geriatric syndrome defined by the concomitant presence of osteopenia/osteoporosis (loss of bone mineral density (BMD)) and sarcopenia (loss of muscle mass and/or function), which increases the risk of falls, fractures, and premature mortality. OBJECTIVE: To examine the efficacy of non-pharmacological (exercise and/or nutritional) interventions on musculoskeletal measures and outcomes in osteosarcopenic adults by reviewing findings from randomized controlled trials (RCTs)...
2021: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/33348603/modified-serum-alp-values-and-timing-of-apparition-of-knee-epiphyseal-ossification-centers-in-preterm-infants-with-cholestasis-and-risk-of-concomitant-metabolic-bone-disease-of-prematurity
#33
JOURNAL ARTICLE
Sandra Llorente-Pelayo, Pablo Docio, Bernardo A Lavín-Gómez, María T García-Unzueta, Isabel de Las Cuevas, Luis de la Rubia, María J Cabero-Pérez, Domingo González-Lamuño
The usefulness of serum alkaline phosphatase (ALP) and phosphorous in screening and monitoring of metabolic bone disease of prematurity (MBDP) still has some limitations, especially in preterm infants with concomitant conditions such as cholestasis. We aimed to assess a modification of serum ALP (M-ALP) as a biomarker for MBDP in preterm infants, and the use of ultrasound monitoring for the apparition of knee ossification centers as marker of bone mineralization. Biochemical and clinical registers were taken from 94 preterm newborns <32 weeks...
December 17, 2020: Nutrients
https://read.qxmd.com/read/33330265/association-of-protein-and-vitamin-d-intake-with-biochemical-markers-in-premature-osteopenic-infants-a-case-control-study
#34
JOURNAL ARTICLE
Mohamed Mohamed, May Kamleh, Julia Muzzy, Sharon Groh-Wargo, Jalal Abu-Shaweesh
Osteopenia in preterm infants (OP) remains an important challenge and is largely dependent on nutritional post-natal intake of factors influencing bone mineralization. We conducted a prospective case-control study to evaluate the importance of protein and vitamin D intake in OP among neonates with birth weight <1,250 g. Simultaneous serum parathyroid hormone (PTH), alkaline phosphatase (ALP), calcium (Ca), phosphorus (P), vitamin D and protein levels were measured during the first six post-natal weeks. At 6 weeks of age, OP was evaluated using wrist radiographs...
2020: Frontiers in Pediatrics
https://read.qxmd.com/read/33321828/metabolic-bone-disease-of-prematurity-risk-factors-and-associated-short-term-outcomes
#35
MULTICENTER STUDY
Alejandro Avila-Alvarez, Adela Urisarri, Jesús Fuentes-Carballal, Natalia Mandiá, Andrea Sucasas-Alonso, María L Couce
Despite the importance of early recognition of metabolic bone disease (MBD) of prematurity, there is still significant variability in screening practices across institutions. We conducted an observational study of infants born at ≤32 weeks of gestation with a birth weight of ≤1500 g (n = 218) to identify clinical factors associated with biochemical indicators of MBD. Bone mineral status was assessed by measuring alkaline phosphatase and phosphate levels between weeks 3 and 5 of life. Two comparisons were performed after classifying infants as either MBD (cases) or non-MBD (controls), and as either high or low risk for MBD, as determined based on the results of MBD screening...
December 10, 2020: Nutrients
https://read.qxmd.com/read/33297406/impact-of-hormonal-replacement-therapy-on-bone-mineral-density-in-premature-ovarian-insufficiency-patients
#36
JOURNAL ARTICLE
Agnieszka Podfigurna, Marzena Maciejewska-Jeske, Malgorzata Nadolna, Paula Mikolajska-Ptas, Anna Szeliga, Przemyslaw Bilinski, Paulina Napierala, Blazej Meczekalski
Premature ovarian insufficiency (POI) is a type of hypergonadotropic hypogonadism caused by impaired ovarian function before the age of 40. Due to the hypoestrogenism, women with POI experience a variety of health complications, including an increased risk of bone mineral density loss and developing osteopenia and osteoporosis, which poses an important problem for public health. Purpose: The aim of this study was to evaluate and compare the values of bone mineral density (BMD), T-score and Z-score within the lumbar spine (L1-L4) using the dual energy X-ray absorptiometry method...
December 7, 2020: Journal of Clinical Medicine
https://read.qxmd.com/read/33266167/convolutional-neural-network-based-humerus-segmentation-and-application-to-bone-mineral-density-estimation-from-chest-x-ray-images-of-critical-infants
#37
JOURNAL ARTICLE
Yung-Chun Liu, Yung-Chieh Lin, Pei-Yin Tsai, Osuke Iwata, Chuew-Chuen Chuang, Yu-Han Huang, Yi-Shan Tsai, Yung-Nien Sun
Measuring bone mineral density (BMD) is important for surveying osteopenia in premature infants. However, the clinical availability of dual-energy X-ray absorptiometry (DEXA) for standard BMD measurement is very limited, and it is not a practical technique for critically premature infants. Developing alternative approaches for DEXA might improve clinical care for bone health. This study aimed to measure the BMD of premature infants via routine chest X-rays in the intensive care unit. A convolutional neural network (CNN) for humeral segmentation and quantification of BMD with calibration phantoms (QRM-DEXA) and soft tissue correction were developed...
November 30, 2020: Diagnostics
https://read.qxmd.com/read/33226632/individualized-versus-standard-diet-fortification-for-growth-and-development-in-preterm-infants-receiving-human-milk
#38
JOURNAL ARTICLE
Veronica Fabrizio, Jennifer M Trzaski, Elizabeth A Brownell, Patricia Esposito, Shabnam Lainwala, Mary M Lussier, James I Hagadorn
BACKGROUND: Human milk as compared to formula reduces morbidity in preterm infants but requires fortification to meet their nutritional needs and to reduce the risk of extrauterine growth failure. Standard fortification methods are not individualized to the infant and assume that breast milk is uniform in nutritional content. Strategies for individualizing fortification are available; however it is not known whether these are safe, or if they improve outcomes in preterm infants. OBJECTIVES: To determine whether individualizing fortification of breast milk feeds in response to infant blood urea nitrogen (adjustable fortification) or to breast milk macronutrient content as measured with a milk analyzer (targeted fortification) reduces mortality and morbidity and promotes growth and development compared to standard, non-individualized fortification for preterm infants receiving human milk at < 37 weeks' gestation or at birth weight < 2500 grams...
November 23, 2020: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/33223743/a-study-of-association-of-premature-graying-of-hair-and-osteopenia-in-north-indian-population
#39
JOURNAL ARTICLE
Mahmood Dhahir Al-Mendalawi
No abstract text is available yet for this article.
May 2020: International Journal of Trichology
https://read.qxmd.com/read/33186760/digestive-involvement-in-a-severe-form-of-snyder-robinson-syndrome-possible-expansion-of-the-phenotype
#40
JOURNAL ARTICLE
Pauline Dontaine, Elisa Kottos, Martine Dassonville, Ovidiu Balasel, Véronique Catros, Julie Soblet, Pascale Perlot, Catheline Vilain
Snyder-Robinson syndrome (OMIM #309583) is a rare X-linked condition, caused by mutation in the SMS gene (MIM *300105), characterized by a wide spectrum of clinical signs including developmental delay, epilepsy, asthenic habitus, dysmorphism, osteopenia, and renal or genital anomalies. Here we describe two maternal half-brothers who both presented with severe neurodevelopmental delay, seizures, hearing loss, facial dysmorphism, renal and ophthalmologic anomalies, failure to thrive and premature death. A novel p...
January 2021: European Journal of Medical Genetics
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