keyword
https://read.qxmd.com/read/38474827/high-initial-dose-of-monitored-vitamin-d-supplementation-in-preterm-infants-hidvid-trial-study-protocol-for-a-randomized-controlled-study
#1
JOURNAL ARTICLE
Dominika Paw, Renata Bokiniec, Alicja Kołodziejczyk-Nowotarska
Vitamin D deficiency can escalate prematurity bone disease in preterm infants and negatively influence their immature immunology system. Infants born at 24 + 0/7 weeks to 32 + 6/7 weeks of gestation will be considered for inclusion. Cord or vein blood samples will be obtained within 48 h after birth for 25-hydroxyvitamin D level measurements. Parathyroid hormone and interleukin-6 levels will be measured. Infants will be randomized to the monitored group (i.e., an initial dose of 1000 IU/day and possible modification) or the controlled group (i...
February 29, 2024: Nutrients
https://read.qxmd.com/read/38387304/bone-mineral-density-in-patients-with-primary-ovarian-insufficiency-a-systematic-review-and-meta-analysis
#2
REVIEW
Mei Jiang, Ying Gao, Hongping Hou, Jing Guo, Wenyuan Li, Tianyu Qin, Minglu Shi, Ling Huang
INTRODUCTION: Premature menopause is a major complication of primary ovarian insufficiency (POI), and this loss is closely relates to bone mineral density (BMD). Previous research has indicated potential associations between BMD and POI. This study set out to provide the first systematic literature review and meta-analysison account of BMD content among women with POI. METHODS: Studies including women with POI and controls were eligible from PubMed, Embase, Cochrane Library and Web of Science databases (from their inception to April 2022)...
February 10, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/37872946/tissue-specific-expression-of-senescence-biomarkers-in-spontaneously-hypertensive-rats-evidence-of-premature-aging-in-hypertension
#3
JOURNAL ARTICLE
Ratthapon Somsura, Kanokwan Kamkajon, Khuanjit Chaimongkolnukul, Surachai Chantip, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Nuntaporn Kamonsutthipaijit, Suwimol Tangtrongsup, Nattapon Panupinthu, Wacharaporn Tiyasatkulkovit, Narattaphol Charoenphandhu
BACKGROUND: Cellular senescence is an age-related physiological process that contributes to tissue dysfunction and accelerated onset of chronic metabolic diseases including hypertension. Indeed, elevation of blood pressure in hypertension coincides with premature vascular aging and dysfunction. In addition, onsets of metabolic disturbance and osteopenia in patients with hypertension have also been reported. It is possible that hypertension enhances premature aging and causes progressive loss of function in multiple organs...
2023: PeerJ
https://read.qxmd.com/read/37578389/prevalence-of-osteopenia-of-prematurity-before-and-after-implementing-an-early-strategy-with-the-use-of-calcium-and-phosphate
#4
JOURNAL ARTICLE
Maria P Carrascal Gutiérrez, María C Janis, Pablo H Brener Dik, María F Galletti, Gonzalo L Mariani
Introduction. With the use of aggressive parenteral nutrition in very low birth weight infants, alterations in calcium and phosphate metabolism were detected. In 2016, a prevention strategy was implemented through calcium phosphate monitoring and early supplementation. Our objective was to study whether this strategy reduces the prevalence of osteopenia and to identify associated risk factors. Population and methods. Quasi-experiment comparing the prevalence of osteopenia between two groups: one after implementing the calcium phosphate monitoring and supplementation strategy (01/01/2017-12/31/2019) and another prior to such intervention (01/01/2013-12/31/2015)...
February 1, 2024: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/36872800/bone-mineral-content-for-preterm-neonates-treated-with-caffeine-using-dual-energy-x-ray-absorptiometry-an-observational-study
#5
JOURNAL ARTICLE
R I H Ismail, H A Awad, M Saber, B M Shehata
BACKGROUND: Prematurity is associated with lots of comorbidities. Premature neonates also have lower bone mineral content (BMC) compared to term neonates. Apnea of prematurity is a common complication and caffeine citrate is widely used for its prevention and treatment. Caffeine also affects creatinine clearance, urine flow rate and releases calcium from its storage sites. OBJECTIVES: The primary objective was to assess BMC in preterm neonates treated with caffeine using dual energy X-ray absorptiometry (DEXA)...
2023: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/36792831/early-elevated-alkaline-phosphatase-as-a-surrogate-biomarker-of-ongoing-metabolic-bone-disease-of-prematurity
#6
JOURNAL ARTICLE
Emmanuelle Motte-Signoret, Marwa Jlassi, Ludivine Lecoq, Pierre-Yves Wachter, Amélie Durandy, Pascal Boileau
UNLABELLED: Very low birth weight (VLBW) neonates present a high risk of metabolic bone disease (MBD). Our main objective was to determine the easiest way to make an early diagnosis of this disease by identifying surrogate biomarkers before any radiological signs occurred. We conducted in our NICU a 6-month observational prospective study, with inclusion of all singleton VLBW neonates. We collected clinical and biological data, and nutritional intakes during hospitalization. We defined biological MBD (bMBD) as alkaline phosphatase (ALP) levels superior to 600 UI/L at day of life 30 (DOL30) and performed a case-control analysis...
April 2023: European Journal of Pediatrics
https://read.qxmd.com/read/36584865/cold-stress-during-room-temperature-housing-alters-skeletal-response-to-simulated-microgravity-hindlimb-unloading-in-growing-female-c57bl6-mice
#7
JOURNAL ARTICLE
Carmen P Wong, Adam J Branscum, Aidan R Fichter, Jennifer Sargent, Urszula T Iwaniec, Russell T Turner
Laboratory mice are typically housed at temperatures below the thermoneutral zone for the species, resulting in cold stress and premature cancellous bone loss. Furthermore, mice are more dependent upon non-shivering thermogenesis to maintain body temperature during spaceflight, suggesting that microgravity-induced bone loss may be due, in part, to altered thermogenesis. Consequently, we assessed whether housing mice at room temperature modifies the skeletal response to simulated microgravity. This possibility was tested using the hindlimb unloading (HLU) model to mechanically unload femora...
December 27, 2022: Biochimie
https://read.qxmd.com/read/36553338/musculoskeletal-and-gait-characteristics-in-patients-with-stickler-syndrome-a-cross-sectional-study
#8
JOURNAL ARTICLE
Juan José Fernández-Pérez, Paloma Mascaraque-Ruiz, Carlos Martín-Gómez, Ignacio Martínez-Caballero, Teresa Otón, Loreto Carmona, Sergio Lerma-Lara
BACKGROUND: Stickler syndrome (SS) is a connective tissue disorder of fibrillary collagen with very variable clinical manifestations, including premature osteoarthritis and osteopenia. This musculoskeletal alteration may affect gait maturity or produce strength difficulties. OBJECTIVE: Our aim was to describe the musculoskeletal characteristics, bone stiffness, gait kinematics, and kinetics of SS patients. METHODS: This is a cross-sectional study of children and youngsters with SS recruited by telephone calls through the Spanish SS Association...
December 2, 2022: Children
https://read.qxmd.com/read/36198696/deletion-of-skeletal-muscle-akt1-2-causes-osteosarcopenia-and-reduces-lifespan-in-mice
#9
JOURNAL ARTICLE
Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Aging is considered to be accelerated by insulin signaling in lower organisms, but it remained unclear whether this could hold true for mammals. Here we show that mice with skeletal muscle-specific double knockout of Akt1/2, key downstream molecules of insulin signaling, serve as a model of premature sarcopenia with insulin resistance. The knockout mice exhibit a progressive reduction in skeletal muscle mass, impairment of motor function and systemic insulin sensitivity. They also show osteopenia, and reduced lifespan largely due to death from debilitation on normal chow and death from tumor on high-fat diet...
October 5, 2022: Nature Communications
https://read.qxmd.com/read/36196312/hutchinson-gilford-progeria-syndrome-a-literature-review
#10
REVIEW
Aselah Lamis, Shiza W Siddiqui, Tejaswini Ashok, Nassar Patni, Mahejabeen Fatima, Asiff Nathi Aneef
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging condition that involves genetic mutations, resulting in debilitating phenotypic features. The present state of knowledge on the molecular pathways that contribute to the pathophysiology of HGPS and the techniques being tested  in vitro  and  in vivo  to combat progerin toxicity have been discussed here. Nuclear morphological abnormalities, dysregulated gene expression, DNA repair deficiencies, telomere shortening, and genomic instability are all caused by progerin accumulation, all of which impair cellular proliferative capability...
August 2022: Curēus
https://read.qxmd.com/read/36120646/-polg-mtdna-mutator-mice-reveal-limited-involvement-of-vertebral-bone-loss-in-premature-aging-related-thoracolumbar-hyperkyphosis
#11
JOURNAL ARTICLE
Olivier Roessinger, Thomas Hügle, Ulrich A Walker, Jeroen Geurts
Background: Age-related hyperkyphosis is multifactorial and involves alterations of vertebral bone, intervertebral discs (IVD) and paraspinal muscles. The relative contribution of these tissues remains unclear. Here, we compared differences in vertebral bone microarchitecture and IVD thickness between prematurely aging mice with spinal hyperkyphosis and wild type littermates. Methods: Thoracolumbar vertebral columns were dissected from homozygous Polg D257A and age-matched wild type littermates...
December 2022: Bone Reports
https://read.qxmd.com/read/36090568/are-we-undertreating-calcium-deficiency-in-metabolic-bone-disease-of-prematurity-a-case-report-and-review
#12
Sirisha Kusuma Boddu, Reena Lankala
BACKGROUND: Both calcium (Ca) and phosphorus (P) are needed to prevent and treat metabolic bone disease (MBDP). However, the predominant focus of many treating neonatologists lies in supplementing P and vitamin D. In this report, we describe a VLBW infant with severe MBDP due to inadequately treated calcium deficiency and discuss the need to recognize this entity. CASE DETAILS AND MANAGEMENT: A 25-week, 700 gm baby boy had chronic lung disease and necrotizing enterocolitis...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/36050673/osteopenia-of-prematurity-and-associated-nutritional-factors-case-control-study
#13
JOURNAL ARTICLE
Mônica Raquel Chaves Pinto, Márcia Maria Tavares Machado, Daniela Vasconcelos de Azevedo, Luciano Lima Correia, Álvaro Jorge Madeiro Leite, Hermano Alexandre Lima Rocha
BACKGROUND: Preterm newborn nutrition affects postnatal skeletal growth and bone mineralization, but studies have not yet fully concluded the relationship between nutrition and osteopenia. This study was intended to investigate the impact of nutritional factors on osteopenia in preterm newborns. METHODS: This is a case-control study with babies born with gestational age ≤ 32 weeks in a high-risk maternity hospital, between 2018 and 2019...
September 1, 2022: BMC Pediatrics
https://read.qxmd.com/read/35915341/effectiveness-and-safety-of-early-versus-late-caffeine-therapy-in-managing-apnoea-of-prematurity-among-preterm-infants-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
Won Zi Yun, Yaman Walid Kassab, Liew Mei Yao, Norliyana Khairuddin, Long Chiau Ming, Muhammad Abdul Hadi
BACKGROUND: Early administration of intravenous (IV) caffeine (initiation within 2 days of life) is an effective treatment strategy for the management of apnoea of prematurity among infants. However, the safety and effectiveness of early administration of oral caffeine treatment is not be fully established. AIM: We aimed to compare the effectiveness and safety of early versus late caffeine therapy on preterm infants' clinical outcomes. METHOD: A retrospective matched cohort study was conducted using data of patients admitted to neonatal intensive care units of two tertiary care hospitals between January 2016 and December 2018...
August 1, 2022: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/35864501/relationship-of-caffeine-regimen-with-osteopenia-of-prematurity-in-preterm-neonates-a-cohort-retrospective-study
#15
JOURNAL ARTICLE
Manoj Kumar, Amin Ali, Muhammad Azeem Khan, Sadia Sohail, Syed Muzafar Saleem, Midhat Khan, Fizzah Naz, Wasif Ahmed Khan, Muhammad Sohail Salat, Kashif Hussain, Gul Ambreen
BACKGROUND: Caffeine is a routinely prescribed pharmacological active compound in neonatal intensive care units (NICU) for treating apnea of prematurity (AOP), which also decreases the risk of bronchopulmonary dysplasia and cerebral palsy in neonates. Caffeine-induced excessive calcium loss can promote the development of metabolic bone disease (MBD) in preterm neonates. This study aimed to evaluate the effect of the caffeine regimen on the development of osteopenia of prematurity (OOP), using serum alkaline phosphatase (serum-ALP) concentrations as a surrogate marker at the 4th week of life...
July 21, 2022: BMC Pediatrics
https://read.qxmd.com/read/35804078/effect-of-physiotherapy-on-the-promotion-of-bone-mineralization-in-preterm-infants-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Galaad Torró-Ferrero, Francisco Javier Fernández-Rego, Juan José Agüera-Arenas, Antonia Gomez-Conesa
Preterm infants have a low level of bone mineralization compared to those born at term. The purpose of the present study was to investigate the effect of reflex locomotion therapy (RLT) on bone mineralization and growth in preterm infants and compare its effect to other physiotherapy procedures. Forty-six preterm infants born at 29-34 weeks were randomized into three groups: one group received RLT (n = 17); the other group received passive movements with gentle joint compression (n = 14); and the control group received massages (n = 15)...
July 8, 2022: Scientific Reports
https://read.qxmd.com/read/35739544/effect-of-physical-therapy-on-bone-remodelling-in-preterm-infants-a-multicenter-randomized-controlled-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Galaad Torró-Ferrero, Francisco Javier Fernández-Rego, María Rosario Jiménez-Liria, Juan Jose Agüera-Arenas, Jessica Piñero-Peñalver, María Del Mar Sánchez-Joya, María Jesús Fernández-Berenguer, Mónica Rodríguez-Pérez, Antonia Gomez-Conesa
BACKGROUND: Preterm infants have a low level of bone mineralization compared to those born at term, since 80% of calcium incorporation occurs at the end of pregnancy. The purpose of the present study was to investigate the effect of reflex locomotion therapy on bone modeling and growth in preterm infants and to compare its effect with those of other Physiotherapy modalities. METHODS: A multicentre randomized controlled clinical trial was conducted (02/2016 - 07/2020)...
June 24, 2022: BMC Pediatrics
https://read.qxmd.com/read/35332257/the-mir-98-3p-jag1-notch1-axis-mediates-the-multigenerational-inheritance-of-osteopenia-caused-by-maternal-dexamethasone-exposure-in-female-rat-offspring
#18
JOURNAL ARTICLE
Hui Han, Hao Xiao, Zhixin Wu, Liang Liu, Ming Chen, Hanwen Gu, Hui Wang, Liaobin Chen
As a synthetic glucocorticoid, dexamethasone is widely used to treat potential premature delivery and related diseases. Our previous studies have shown that prenatal dexamethasone exposure (PDE) can cause bone dysplasia and susceptibility to osteoporosis in female rat offspring. However, whether the effect of PDE on bone development can be extended to the third generation (F3 generation) and its multigenerational mechanism of inheritance have not been reported. In this study, we found that PDE delayed fetal bone development and reduced adult bone mass in female rat offspring of the F1 generation, and this effect of low bone mass caused by PDE even continued to the F2 and F3 generations...
March 2022: Experimental & Molecular Medicine
https://read.qxmd.com/read/35006191/p065-a-one-time-education-for-gastroenterologists-regarding-osteoporosis-screening-for-ibd-patients-improves-provider-knowledge-but-not-screening-rates
#19
JOURNAL ARTICLE
Subin Chirayath, Dhruv Patel, Dhruvanshu Patel, Parampreet Kaur, Yecheskel Schneider
BACKGROUND: Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal inflammatory condition and has been increasing in prevalence in the United States, with a 30-40% increase over the past few decades. Osteoporosis can be seen in up to 40% of IBD patients. Screening for osteoporosis in IBD patients involves the use of DEXA scans and is recommended by the IBD Cornerstone Committee for select patients, including steroid use > 3 months consecutively or a total of 1 year in the past 2 years, family history of osteoporosis, malnutrition, amenorrheic or post-menopausal...
December 1, 2021: American Journal of Gastroenterology
https://read.qxmd.com/read/34734916/catch-it-before-it-breaks-managing-metabolic-bone-disease-of-prematurity
#20
REVIEW
Folasade Kehinde, Andreea Marinescu, Renee Turchi
PURPOSE OF REVIEW: Metabolic bone disease of prematurity, commonly referred to as osteopenia of prematurity, remains prevalent in the neonatal intensive care unit (NICU) despite recent medical advances. It is estimated that up to 60% of extreme low birth weight and 20% of very low-birth-weight infants have metabolic bone disease of prematurity. Often silent, it typically presents with poor growth, increased ventilator dependency and fractures. Clinical sequalae, such as short stature can extend into young adulthood...
December 1, 2021: Current Opinion in Pediatrics
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