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Osteopenia of prematurity

Enas A A Abdallah, Reem N Said, Dalia S Mosallam, Eman M I Moawad, Naglaa M Kamal, Mohammed G E-D Fathallah
Metabolic bone disease of prematurity is a condition characterized by reduction in bone mineral content (osteopenia). It is a problem faced by very low birth weight (VLBW) infants because of lack of fetal mineralization during the last trimester. Our aim was to assess serum alkaline phosphatase (ALP) level as an early biomarker for osteopenia in premature infants and to estimate an optimal cutoff value of serum ALP at which osteopenia is detected radiologically in premature newborns.This prospective study was conducted on a cohort of 120 newborn infants of both sex of ≤34 weeks' gestational age and <1500 g birth weight...
September 2016: Medicine (Baltimore)
Chander Kumar Lohana, Nafisa Samir
BACKGROUND: Postmenopausal females are susceptible to osteoporosis due to clinical manifestations. It not only causes morbidity; but, is considered to strikingly decline quality of life among patients. Among different developing regions, the prevalence rate of osteoporosis among postmenopausal women is alarming in the face of poor management and awareness about its risk factors. AIM: The aim of this study was to investigate the incidence of osteoporosis and its known risk factors among postmenopausal women appearing for bone mineral density in Karachi...
2016: Global Journal of Health Science
Kelsey A Stalnaker, Gail A Poskey
Bone mineralization of preterm infants is significantly less than full-term infants at birth, placing preterm infants at risk for osteopenia of prematurity and other metabolic bone diseases. Advances in nutritional supplementation and standard nursing care alone have been unsuccessful in improving bone mineralization postnatally. Research supports a daily physical activity protocol of passive range of motion and gentle joint compression when combined with adequate nutritional supplementation reduces osteopenia of prematurity...
2016: Neonatal Network: NN
T Koehne, A Jeschke, F Petermann, S Seitz, M Neven, S Peters, J Luther, M Schweizer, T Schinke, B Kahl-Nieke, M Amling, J-P David
The ribosomal S6 kinase RSK2 is essential for osteoblast function, and inactivating mutations of RSK2 cause osteopenia in humans with Coffin-Lowry syndrome (CLS). Alveolar bone loss and premature tooth exfoliation are also consistently reported symptoms in CLS patients; however, the pathophysiologic mechanisms are unclear. Therefore, aiming to identify the functional relevance of Rsk2 for tooth development, we analyzed Rsk2-deficient mice. Here, we show that Rsk2 is a critical regulator of cementoblast function...
July 2016: Journal of Dental Research
D Santi, B Madeo, F Carli, S Zona, G Brigante, F Vescini, G Guaraldi, V Rochira
SUMMARY: By investigating the relationship between serum testosterone, estradiol, and bone mineral density (BMD) in a large cohort of HIV-infected men, estradiol was associated with BMD, relative estrogen deficiency being involved in bone loss in men with hypogonadism, in addition to all HIV-related factors. Increased aromatization in adipose tissue does not counteract HIV-related bone loss. INTRODUCTION: The purpose of this study is to evaluate the relationship between serum testosterone, estradiol, and BMD in a large cohort of HIV-infected men...
March 2016: Osteoporosis International
Sue S T Lo
OBJECTIVES: To evaluate the prevalence of osteoporosis in treatment-naïve postmenopausal women, their treatment adherence, and the risk factors for osteoporosis. DESIGN: Cross-sectional study of bone density reports, a self-administered health checklist, and computerised consultation records. SETTING: Primary care sexual and reproductive health service in Hong Kong. PARTICIPANTS: Postmenopausal Chinese women who had never received osteoporosis treatment or hormone replacement therapy...
December 2015: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
M A Mannan, I Jahan, M Z Rahman, Z Hasan, A C Dey, M Shahidullah
The continuous advances in intensive care have led to increased survival of premature infants. As a consequence, the problem of less imminent, slowly progressing disorders such as osteopenia of prematurity has been emerging. Osteopenia of prematurity (OOP) also called metabolic bone disease of prematurity (MBD) or rickets of prematurity is characterized by a reduction in bone mineral content usually manifest between 6th to 12th weeks of corrected gestational age. It occurs in up to 55% of infants born with weight <1000gm and 23% of infants weighing <1500gm...
July 2015: Mymensingh Medical Journal: MMJ
Ping-Hsing Tsai, Yueh Chien, Jen-Hua Chuang, Shih-Jie Chou, Chian-Hsu Chien, Ying-Hsiu Lai, Hsin-Yang Li, Yu-Lin Ko, Yuh-Lih Chang, Chen-Ying Wang, Yung-Yang Liu, Hsin-Chen Lee, Chang-Hao Yang, Ting-Fen Tsai, Yi-Yen Lee, Shih-Hwa Chiou
Wolfram syndrome 2 (WFS2) is a premature aging syndrome caused by an irreversible mitochondria-mediated disorder. Cisd2, which regulates mitochondrial electron transport, has been recently identified as the causative gene of WFS2. The mouse Cisd2 knockout (KO) (Cisd2(-/-)) recapitulates most of the clinical manifestations of WFS2, including growth retardation, osteopenia, and lordokyphosis. However, the precise mechanisms underlying osteopenia in WFS2 and Cisd2 KO mice remain unknown. In this study, we collected embryonic fibroblasts from Cisd2-deficient embryos and reprogrammed them into induced pluripotent stem cells (iPSCs) via retroviral transduction with Oct4/Sox2/Klf4/c-Myc...
November 1, 2015: Stem Cells and Development
Toshifumi Sugatani, Olga Agapova, Hartmut H Malluche, Keith A Hruska
Deficiency of Sirtuin 6 (SIRT6), a chromatin-related deacetylase, in mice reveals severe premature aging phenotypes including osteopenia. However, the underlying molecular mechanisms of SIRT6 in bone metabolism are unknown. Here we show that SIRT6 deficiency in mice produces low-turnover osteopenia caused by impaired bone formation and bone resorption, which are mechanisms similar to those of age-related bone loss. Mechanistically, SIRT6 interacts with runt-related transcription factor 2 (Runx2) and osterix (Osx), which are the two key transcriptional regulators of osteoblastogenesis, and deacetylates histone H3 at Lysine 9 (H3K9) at their promoters...
December 2015: Bone
Duygu Besnili Acar, Sultan Kavuncuoğlu, Merih Çetinkaya, Ercüment Petmezci, Mesut Dursun, Orhan Korkmaz, Emel Kayrak Altuncu
AIM: In this study, we aimed to investigate the utility of tubular reabsorption of phosphorus in the diagnosis of osteopenia of prematurity in addition to biochemical markers. MATERIALS AND METHOD: Premature babies with a gestational age of ≤32 weeks and/or a birth weight of ≤1 500 g who were hospitalized in the neonatal intensive care unit between June 2009 and March 2011 were included in the study. These babies were evaluated at the 40th gestational week and serum calcium, phosphorus, alkaline phosphatase, urea, creatinine, urinary calcium and phosphorus levels were measured and tubular reabsorption of phosphorus was determined...
March 2015: Türk Pediatri Arşivi
Kannikar Wongdee, Narattaphol Charoenphandhu
It was previously understood that body weight gain and obesity observed in type 2 diabetes mellitus (T2DM) could be beneficial since body weight increase elevated bone mineral density and thus helped maintain the skeletal framework. However, a number of recent findings in humans and rodents have revealed that T2DM is not only associated with trabecular defects but also increases cortical porosity, and compromised bone cell function and bone mechanical properties. Hyperglycemia and insulin resistance in T2DM may further induce osteoblast apoptosis and uncoupling bone turnover...
June 10, 2015: World Journal of Diabetes
Angela Machado, Gustavo Rocha, Ana Isabel Silva, Nuno Alegrete, Hercília Guimarães
INTRODUCTION: Fractures during the neonatal period are rare. Some fractures, especially long bones, may occur during birth. Moreover, neonates hospitalized in the Neonatal Intensive Care Unit have an increased risk of fractures for several reasons. OBJECTIVE: To evaluate the incidence and characterize fractures in newborns admitted in a tertiary Neonatal Intensive Care Unit. MATERIAL AND METHODS: A retrospective analysis of the newborns admitted to the Neonatal Intensive Care Unit with a diagnosis at discharge of one or more bone fractures from January 1996 to June 2013...
March 2015: Acta Médica Portuguesa
Meera Khorana, Chanin Jiamsajjamongkhon
BACKGROUND: Nutrition is an important aspect in the care of very low birth weight (VLBW) preterm infants. Human milk fortified with human milk fortifiers (HMF) is best for enteral feeding of premature infants. HMF is expensive and not easily available in Thailand. Post discharge formula (PDF) has been routinely used to fortify human milk at Queen Sirikit National Institute of Child Health (QSNICH) but there is lack of supportive data regarding efficacy and safety. OBJECTIVE: To study and compare anthropometrics, biochemical markers and complications in VLBW infants fed human milk fortified with either HMF or PDF...
June 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Uraiwan Chotigeat, Jarinthorn Vongpakorn
OBJECTIVE: To evaluate the post-discharge growth, laboratory outcome, neurodevelopment and safety of post-discharge formula in comparison to breast milk. MATERIAL AND METHOD: A prospective cohort of preterm infants, who were discharged on breast milk or post-discharge formula (PDF) were studied. Demographic data, post-discharge growth, laboratory outcome, neurodevelopment and complications were recorded. These infants were followed-up at 40 weeks' postmenstrual age (PMA) 2, 4 and 6 months' corrected age...
June 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Nicholas P Clayton, Carol A Nelson, Timothy Weeden, Kristin M Taylor, Rodney J Moreland, Ronald K Scheule, Lucy Phillips, Andrew J Leger, Seng H Cheng, Bruce M Wentworth
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC and the resultant progressive lysosomal accumulation of glycogen in skeletal and cardiac muscles. Enzyme replacement therapy using recombinant human GAA (rhGAA) has proven beneficial in addressing several aspects of the disease such as cardiomyopathy and aberrant motor function. However, residual muscle weakness, hearing loss, and the risks of arrhythmias and osteopenia persist despite enzyme therapy...
2014: Molecular Therapy. Nucleic Acids
Paymaneh Alizadeh Taheri, Negar Sajjadian, Bahram Beyrami, Mamak Shariat
Osteopenia of prematurity (OOP) is a preventable disease. Improved survival of premature newborns is associated with an increased incidence of OOP. The purpose of this study was to compare the prophylactic effects of two low doses of vitamin D (200 and 400 IU/Day) on the clinical, biochemical and radiological indices of the rickets of prematurity. In a randomized clinical trial, 60 preterm newborns with birth weight < 2000 g & gestational age < 37 weeks were randomly divided in two groups. Thirty newborns received 200 IU/d of vitamin D in group one and 30 ones received 400 IU/day of vitamin D in group two...
2014: Acta Medica Iranica
E Iu Maĭchuk, I V Voevodina, T V Mitrokhina, I A Makarova, S V Iureneva
AIM: To study the formation of and trends in risk factors (RFs) for cardiovascular disease (CVD), their influence on the occurrence of early (preclinical) atherosclerotic lesions, a combination of these changes with osteoporosis (OP) in women following bilateral oophorectomy depending on whether hormone replacement therapy (HRT) is performed. SUBJECTS AND METHODS: The investigation enrolled 50 women with surgical menopause after bilateral oophorectomy in combination with hysterectomy who received estrogen monotherapy (a study group) and 37 patients who underwent the same operation, but had no HRT (a control group)...
2014: Terapevticheskiĭ Arkhiv
Zohre Torabi, Nouraddin Moemeni, Akefeh Ahmadiafshar, Saeideh Mazloomzadeh
OBJECTIVE: To determine the impact of calcium and phosphorus on radiological and biochemical characteristics of osteopenia in premature infants. METHODS: The randomised clinical trial study was conducted at Valie-e-Asr Hospital of Zanjan city, Iran, from December 2010 to June 2011. It involved monitoring 40 premature neonates over a period of six months. The babies, who were fed with breast milk and 400 units of vitamin D daily, were randomly divided into two equal groups...
June 2014: JPMA. the Journal of the Pakistan Medical Association
Zuzana Saidak, Carole Le Henaff, Sofia Azzi, Caroline Marty, Pierre J Marie
Intermittent administration of parathyroid hormone (PTH) 1-34 at a standard dose has been shown to induce anabolic effects in bone. However, whether low-dose PTH promotes bone formation during senescence is unknown. To address this issue, we determined the effects of low-dose PTH and analysed the underlying mechanisms in prematurely senescent mice that display osteopenia. Treatment of 9-week-old Samp6 mice for 6 weeks with PTH at a standard dose (100 μg/kg per day) increased vertebral and femoral bone mass and improved bone microarchitecture as a result of increased bone-forming surfaces and mineral apposition rate (MAR)...
October 2014: Journal of Endocrinology
Gül Yeşiltepe Mutlu, Heves Kırmızıbekmez, Elif Ozsu, Ilkay Er, Sükrü Hatun
Osteopenia of prematurity has become a common problem recently because of improved survival rates of infants with very low birth weight (VLBW). The incidence of neonatal osteopenia is inversely correlated with gestational age and birth weight. Herein, we present four cases of preterm osteopenia that were referred to the pediatric endocrinology outpatient clinic with diverse clinical and laboratory findings and we discuss the clinical course of these infants with regard to bone disease after discharge from the neonatal intensive care unit (NICU)...
2014: Journal of Clinical Research in Pediatric Endocrinology
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