Belén Blázquez-Tapias, Satyajit Halder, M Antonia Mendiola, Nivedita Roy, Nilima Sahu, Chittaranjan Sinha, Kuladip Jana, Elena López-Torres
Nowadays, the search for new chemotherapeutic agents with low toxicity and high selectivity is a major concern. In this paper, we report the synthesis and characterization of a hybrid thiosemicarbazone/hydrazone ligand in its neutral form (L1 H2 ) and as the chloride salt ([L1 H3 ]Cl)-, three diorganotin (IV) complexes, and one complex with Sn (IV). The compounds have been fully characterized by IR, mass spectra, 1 H, 13 C, and 119 Sn NMR, 119 Sn CP/MAS NMR, and by single crystal X-ray diffraction. The organotin compounds have the empirical formula [SnR2 L1 ] ( R = Me, Bu, and Ph), but in the solid state, they are polymeric species with seven coordination number due to weak coordination of the pyridine nitrogen, whereas in solution, the polymeric structure is lost to afford hexacoordinate monomeric species...
2024: Bioinorganic Chemistry and Applications