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osteomyelitis; delivery

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https://www.readbyqxmd.com/read/27894964/approach-to-osteomyelitis-treatment-with-antibiotic-loaded-pmma
#1
REVIEW
Wentao Zhang, Guangyu Lei, Yang Liu, Wei Wang, Tao Song, Jinzhu Fan
BACKGROUND: To reduce the incidence of osteomyelitis infection, local antibiotic impregnated delivery systems are commonly used as a promising and effective approach to deliver high antibiotic concentrations at the infection site. OBJECTIVE: The objective of this review was to provide a literature review regarding approach to osteomyelitis treatment with antibiotic loaded PMMA. STUDY DESIGN: Literature study regarding osteomyelitis treatment with antibiotic loaded carriers using key terms Antibiotic, osteomyelitis, biodegradable PMMA through published articles...
November 26, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27822001/osteomyelitis-recent-advances-in-pathophysiology-and-therapeutic-strategies
#2
REVIEW
Mitchell C Birt, David W Anderson, E Bruce Toby, Jinxi Wang
This review article summarizes the recent advances in pathogenic mechanisms and novel therapeutic strategies for osteomyelitis, covering both periprosthetic joint infections and fracture-associated bone infections. A better understanding of the pathophysiology including the mechanisms for biofilm formation has led to new therapeutic strategies for this devastating disease. Research on novel local delivery materials with appropriate mechanical properties, lower exothermicity, controlled release of antibiotics, and absorbable scaffolding for bone regeneration is progressing rapidly...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27713087/a-nanovehicle-developed-for-treating-deep-seated-bacteria-via-using-low-dose-x-ray
#3
Chien-Lin Pan, Ming-Hong Chen, Fu-I Tung, Tse-Ying Liu
: Many non-antibiotic strategies, such as photocatalysis and photodynamic therapy, have been proposed to inhibit and/or kill bacteria. However, these approaches still have drawbacks such as insufficient bacterial specificity and the limited penetration depth of ultraviolet and near-infrared light. To overcome these limitations, we developed a bacteria-specific anti-bacterial technique via using low-dose X-ray. Graphene oxide quantum dots (GQDs, a multifunctional vehicle) conjugated with vancomycin (Van, a bacteria-targeting ligand) were assembled with Protoporphyrin IX (PpIX, a photo/radiation sensitizer) to yield a novel Van-GQDs/PpIX complex that specifically attached to Escherichia coli and efficiently generated intracellular reactive oxygen species following X-ray activation...
October 3, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27693717/understanding-osteomyelitis-and-its-treatment-through-local-drug-delivery-system
#4
Samit Kumar Nandi, Samiran Bandyopadhyay, Piyali Das, Indranil Samanta, Prasenjit Mukherjee, Subhasis Roy, Biswanath Kundu
Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics is not an effective way to control the malaise due to so many reasons. Determination of optimal treatment strategy becomes difficult for the orthopaedic surgeons and as a consequence, the patients suffer not only from therapeutic failure but also due to adverse side effects of antibiotics and financial loss due to additional stay at hospitals. A wide application of carrier systems, as a medium for local delivery of antibiotics, is being used experimentally and clinically for the treatment of osteomyelitis...
September 28, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/27678329/pharmacokinetics-of-gentamicin-eluted-from-a-regenerating-bone-graft-substitute-in-vitro-and-clinical-release-studies
#5
M Stravinskas, P Horstmann, J Ferguson, W Hettwer, M Nilsson, S Tarasevicius, M M Petersen, M A McNally, L Lidgren
OBJECTIVES: Deep bone and joint infections (DBJI) are directly intertwined with health, demographic change towards an elderly population, and wellbeing.The elderly human population is more prone to acquire infections, and the consequences such as pain, reduced quality of life, morbidity, absence from work and premature retirement due to disability place significant burdens on already strained healthcare systems and societal budgets.DBJIs are less responsive to systemic antibiotics because of poor vascular perfusion in necrotic bone, large bone defects and persistent biofilm-based infection...
September 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27587217/-progress-of-different-drug-delivery-route-of-vancomycin-for-the-treatment-of-chronic-osteomyelitis
#6
Y Z Long, Z X Zhu, Y Yu, S M Zhang
Chronic osteomyelitis (COM) is an infectious disease caused by methicillin-resistant Staphylococcus aureus (MRSA), the main characteristics of COM including local dead bone formation, soft tissue infection, and repeatedly attacks. As a sensitive antibiotic, vancomycin plays an important role in the therapy of COM caused by MRSA. Currently, drug treatment is divided into systemic and topical, systemic medication is given priority to intravenous drug delivery; local drug application including local delivery device and local antibiotics lavage and regional arterial perfusion...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27520562/bioactive-natural-polymeric-scaffolds-loaded-with-ciprofloxacin-for-treatment-of-osteomyelitis
#7
Amany A Mostafa, Mayyada M H El-Sayed, Azza A Mahmoud, Amira M Gamal-Eldeen
Local delivery of antibiotic into injured bone is a demand. In this work, different scaffolds of chitosan (C) with or without bioactive glass (G) were prepared using the freeze-drying technique in 2:1, 1:1, and 1:2 weight ratios. Chitosan scaffolds and selected formulas of chitosan to bioglass were loaded with ciprofloxacin in 5%, 10%, and 20% w/w. Scaffold morphology showed an interconnected porous structure, where the glass particles were homogeneously dispersed in the chitosan matrix. The kinetic study confirmed that the scaffold containing 1:2 weight ratio of chitosan to glass (CG12) showed optimal bioactivity with good compromise between Ca and P uptake capacities and Si release rate...
August 12, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27472197/local-intramedullary-delivery-of-vancomycin-can-prevent-the-development-of-long-bone-staphylococcus-aureus-infection
#8
Catherine Loc-Carrillo, Caroline Wang, Ahranee Canden, Michael Burr, Jayant Agarwal
Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin...
2016: PloS One
https://www.readbyqxmd.com/read/27441531/-local-antibiotic-therapy-of-osteomyelitis-using-nonabsorbable-implant-review
#9
B Tuleubaev, D Saginova, T Abiyev, M Davletbaev, A Koshanova
Despite the variety of treatments available, including surgical procedures and antimicrobial therapy, bone infections is still a medical problem, because they are difficult to treat. Optimal treatment should stabilize the bone, promote the biological recovery of bone defects and destroy bacterial infection. Systemic antibiotics are part of the standard therapy after surgical treatment of infected bone, but their effectiveness is limited due to malnutrition and low absorption at the site of infection. Moreover, long-term treatment and higher doses are associated with serious side effects...
June 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27424376/methicillin-resistant-staphyloccocus-aureus-intracranial-epidural-abscess-with-osteomyelitis-during-pregnancy-a-case-report
#10
Vaya W Tanamai, Brandon-Luke L Seagle, Guoyang Luo
BACKGROUND: The incidence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing, and 0.5-4% of pregnant women are colonized. CASE: A 30-year-old pregnant woman at term presented with intractable headache 1 week after incision and drainage of a MRSA-positive axillary abscess. Imaging demonstrated a right-sided epidural abscess with midline shift and myositis of the overlying temporalis muscle. She underwent cesarean delivery followed by craniectomy of osteomyelitic bone and evacuation of the epidural abscess...
May 2016: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27347359/calcium-phosphate-as-a-key-material-for-socially-responsible-tissue-engineering
#11
Vuk Uskoković, Victoria M Wu
Socially responsible technologies are designed while taking into consideration the socioeconomic, geopolitical and environmental limitations of regions in which they will be implemented. In the medical context, this involves making therapeutic platforms more accessible and affordable to patients in poor regions of the world wherein a given disease is endemic. This often necessitates going against the reigning trend of making therapeutic nanoparticles ever more structurally complex and expensive. However, studies aimed at simplifying materials and formulations while maintaining the functionality and therapeutic response of their more complex counterparts seldom provoke a significant interest in the scientific community...
June 2016: Materials
https://www.readbyqxmd.com/read/27324764/repurposing-the-nonsteroidal-anti-inflammatory-drug-diflunisal-as-an-osteoprotective-antivirulence-therapy-for-staphylococcus-aureus-osteomyelitis
#12
Andrew S Hendrix, Thomas J Spoonmore, Aimee D Wilde, Nicole E Putnam, Neal D Hammer, Daniel J Snyder, Scott A Guelcher, Eric P Skaar, James E Cassat
Staphylococcus aureus osteomyelitis is a common and debilitating invasive infection of bone. Treatment of osteomyelitis is confounded by widespread antimicrobial resistance and the propensity of bacteria to trigger pathological changes in bone remodeling that limit antimicrobial penetration to the infectious focus. Adjunctive therapies that limit pathogen-induced bone destruction could therefore limit morbidity and enhance traditional antimicrobial therapies. In this study, we evaluate the efficacy of the U...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27300006/insights-on-the-properties-of-levofloxacin-adsorbed-sr-and-mg-doped-calcium-phosphate-powders
#13
Catarina F Marques, Ana C Matos, Isabel A C Ribeiro, Lídia M Gonçalves, Ana Bettencourt, José M F Ferreira
Several types of biodegradable materials have been investigated for the treatment of osteomyelitis. Calcium phosphate (CaP) ceramics are among the most performing materials due to their resemblance to human hard tissues in terms of mineralogical composition, and proven ability to adsorb and deliver a number of drugs. This research work was intended to study the suitability of modified CaP powders loaded with a fluoroquinolone as drug delivery systems for osteomyelitis treatment. Levofloxacin (LEV) was chosen due to the well-recognized anti-staphylococcal activity and adequate penetration into osteoarticular tissues...
July 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27066799/infected-cephalohematomas-and-underlying-osteomyelitis-a-case-based-review
#14
Michael D Staudt, Daniel Etarsky, Adrianna Ranger
BACKGROUND: Cephalohematomas are relatively common sub-periosteal collections of blood that tend to resolve spontaneously without treatment. Rarely, they become infected and can be associated with underlying osteomyelitis, meningitis, or sepsis. Common pathogens include Escherichia coli and Staphylococcus species. ILLUSTRATIVE CASE: This report describes the first case of a neonate developing an infected right parietal cephalohematoma and underlying osteomyelitis caused by Morganella morganii, which was cultured in blood and cephalohematoma aspirate...
August 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27013218/a-therapeutic-delivery-system-for-chronic-osteomyelitis-via-a-multi-drug-implant-based-on-three-dimensional-printing-technology
#15
Weigang Wu, Chenyi Ye, Qixin Zheng, Gui Wu, Zhaohui Cheng
Chronic osteomyelitis is difficult to be cured and often relapses, which presents to be a great challenge to clinicians. We conducted this original study to explore the efficiency of therapeutic alliance for chronic osteomyelitis by a multi-drug implant based on three-dimensional printing technology. We designed and fabricated preciously a multi-drug implant with a multi-layered concentric cylinder construction by three-dimensional (3D) printing technology. Levofloxacin and tobramycin were incorporated into the drug implant in a specific sequence...
August 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27004369/a-new-device-for-efficient-preparation-of-standard-antibiotic-bead-chains-and-customized-antibiotic-delivery
#16
Baochang Qi, Weina Ju, Tiecheng Yu, Tiejun Wang, Yi Zhao, Dahui Sun
Antibiotic-loaded polymethylmethacrylate (PMMA) beads are widely used in orthopedic practice for the prevention of infections after open fractures and in the management of osteomyelitis. The use of commercial beads is limited by insufficient flexibility, lack of provision for selection of specific antibiotic, and short drug-release time. Further, the manual procedure for the preparation of PMMA beads is slow, and the products are not uniform in size. Uniformity of the bead size is crucial because the placement of oversized beads place at sites with limited space (e...
February 2016: Die Pharmazie
https://www.readbyqxmd.com/read/26929860/a-rare-full-term-newborn-case-of-rib-osteomyelitis-with-suspected-preceding-fracture
#17
Sahoko Ono, Hiroki Fujimoto, Yutaka Kawamoto
Acute osteomyelitis is uncommon in full-term neonates and occurs most frequently in those with critical illnesses, often following episodes of sepsis, skin infection, umbilical catheterization, urinary tract anomalies, or a complicated delivery. Here, we report a very rare case of acute rib osteomyelitis due to Staphylococcus aureus in a 13-day-old full-term male neonate. Ultrasonography (US) enabled diagnosis and revealed a coexisting costochondral junction rib fracture, which was not detected on routine chest radiography...
March 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/26929622/development-of-nanoantibiotic-delivery-system-using-cockle-shell-derived-aragonite-nanoparticles-for-treatment-of-osteomyelitis
#18
Lamin Saidykhan, Md Zuki Bin Abu Bakar, Yaya Rukayadi, Aminu Umar Kura, Saiful Yazan Latifah
A local antibiotic delivery system (LADS) with biodegradable drug vehicles is recognized as the most effective therapeutic approach for the treatment of osteomyelitis. However, the design of a biodegradable LADS with high therapeutic efficacy is too costly and demanding. In this research, a low-cost, facile method was used to design vancomycin-loaded aragonite nanoparticles (VANPs) with the aim of understanding its potency in developing a nanoantibiotic bone implant for the treatment of osteomyelitis. The aragonite nanoparticles (ANPs) were synthesized from cockle shells by a hydrothermal approach using a zwitterionic surfactant...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/26891748/calcium-phosphate-nanocoatings-and-nanocomposites-part-2-thin-films-for-slow-drug-delivery-and-osteomyelitis
#19
Besim Ben-Nissan, Innocent Macha, Sophie Cazalbou, Andy H Choi
During the last two decades although many calcium phosphate based nanomaterials have been proposed for both drug delivery, and bone regeneration, their coating applications have been somehow slow due to the problems related to their complicated synthesis methods. In order to control the efficiency of local drug delivery of a biomaterial the critical pore sizes as well as good control of the chemical composition is pertinent. A variety of calcium phosphate based nanocoated composite drug delivery systems are currently being investigated...
2016: Nanomedicine
https://www.readbyqxmd.com/read/26876651/poly-trimethylene-carbonate-as-a-carrier-for-rifampicin-and-vancomycin-to-target-therapy-recalcitrant-staphylococcal-biofilms
#20
Otto S Kluin, Henk J Busscher, Daniëlle Neut, Henny C van der Mei
Standard antibiotic therapy in osteomyelitis patients is of limited value when methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), or small-colony variants (SCV) are present. Far better results are obtained by local drug delivery of antibiotic combinations including rifampicin, using a suitable carrier. We therefore investigated release kinetics of antibiotics from biodegradable poly(trimethylene carbonate) (PTMC) and in vitro biofilm inhibition of MRSA, MRSE, and S. aureus SCV strains in the course of 24, 72 and 168 h treatment by PTMC, either unloaded, gentamicin-loaded, loaded with rifampicin and fosfomycin or rifampicin and vancomycin...
February 15, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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