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osteomyelitis; gene

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https://www.readbyqxmd.com/read/27931782/radiographic-presentation-of-musculoskeletal-involvement-in-werner-syndrome-adult-progeria
#1
A David, M Vincent, P P Arrigoni, S Barbarot, M A Pistorius, B Isidor, E Frampas
Werner syndrome (i.e., adult progeria) is a rare autosomal recessive disorder caused by mutations of the WRN gene, which is characterized by the premature appearance of features associated with normal aging and cancer predisposition. Patients with Werner syndrome can present with musculoskeletal complaints, associated with suggestive radiographic features with a potential prognostic or therapeutic impact. This review illustrates the main radiographic features of Werner syndrome, focusing on the musculoskeletal system, such as soft-tissue calcification, muscular atrophy, osteoporosis, foot deformities, osteitis and osteomyelitis, and bone or soft-tissues malignancies...
December 5, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27904045/puerarin-prevents-lps-induced-osteoclast-formation-and-bone-loss-via-inhibition-of-akt-activation
#2
Yun Zhang, Ming Yan, Qing-Feng Yu, Pei-Fan Yang, Hai-Dong Zhang, Yong-Hong Sun, Zhi-Fen Zhang, Yun-Feng Gao
Osteolysis induced by chronic Gram-negative bacterial infection underlies many bone diseases such as osteomyelitis, septic arthritis, and periodontitis. Drugs that inhibit lipopolysaccharide (LPS)-induced osteolysis are critically needed for the prevention of bone destruction in infective bone diseases. In this study, we assessed the effect of puerarin, a natural isoflavone isolated from Pueraria lobata OHWI root, on LPS-induced osteoclastogenesis and bone loss. Our in vitro study showed that puerarin significantly inhibited LPS-induced osteoclast differentiation from osteoclast precursor RAW264...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27882078/debridement-in-chronic-osteomyelitis-with-benign-osteopetrosis-a-case-report
#3
Yu-Ping Liu, Xiang-Hua Lin, Man-Yun Yan, Bao-Quan Lin, Ming-Ying Zhuo
Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impaired bone resorption ability. An accumulation of cortical bone mass during the remodeling of the medullary bone may increase the bone density and give rise to a hard marble consistency. Osteopetrosis can be divided into benign and malignant forms; however, no curative treatment exists for benign osteopetrosis...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881195/the-involvement-of-runx2-and-sparc-genes-in-the-bacterial-chondronecrosis-with-osteomyelitis-in-broilers
#4
E Paludo, A M G Ibelli, J O Peixoto, F C Tavernari, C A V Lima-Rosa, J R C Pandolfi, M C Ledur
Economic losses due to an increase of leg disorders in broilers have become a major concern of the poultry industry. Despite the efforts to reduce skeletal abnormalities in chickens, insufficient progress has been made. Bacterial chondronecrosis with osteomyelitis (BCO) is one of the main disorders that affect bone integrity in broilers. However, the genetic pathways and genes involved in most bone problems, including BCO, remains unclear. In this study, femoral samples from male broilers with 45 days of age affected or not with BCO were used to compare the relative expression with a reverse transcription real time PCR approach of 13 candidate genes: SPP1 (osteopontin), TNFRSF11B (osteoprotegerin), SPARC (osteonectin), CALB1 (calbidin 1), CALM (Calmodulin 2), IBSP (sialoprotein), COL1A2 (collagen, type I, α 2), BMP2 (bone morphogenetic protein 2), BMP3 (bone morphogenetic protein 3), RANKL (κ-B nuclear factor ligand), SMAD1 (SMAD family member 1), LEPR (leptin receptor) and RUNX2 (related transcription factor Runt 2)...
November 24, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27779811/biofilm-formation-and-antimicrobial-susceptibility-of-staphylococci-and-enterococci-from-osteomyelitis-associated-with-percutaneous-orthopaedic-implants
#5
Magdalena Zaborowska, Jonatan Tillander, Rickard Brånemark, Lars Hagberg, Peter Thomsen, Margarita Trobos
Staphylococci and enterococci account for most deep infections associated with bone-anchored percutaneous implants for amputation treatment. Implant-associated infections are difficult to treat; therefore, it is important to investigate if these infections have a biofilm origin and to determine the biofilm antimicrobial susceptibility to improve treatment strategies. The aims were: (i) to test a novel combination of the Calgary biofilm device and a custom-made susceptibility MIC plate (Sensititre(®) ), (ii) to determine the biofilm formation and antimicrobial resistance in clinical isolates causing implant-associated osteomyelitis, and (iii) to describe the associated clinical outcome...
October 25, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27765018/arthropathy-related-pain-in-a-patient-with-congenital-impairment-of-pain-sensation-due-to-hereditary-sensory-and-autonomic-neuropathy-type-ii-with-a-rare-mutation-in-the-wnk1-hsn2-gene-a-case-report
#6
Keiko Yamada, Junhui Yuan, Tomoo Mano, Hiroshi Takashima, Masahiko Shibata
BACKGROUND: Hereditary sensory and autonomic neuropathy (HSAN) type II with WNK1/HSN2 gene mutation is a rare disease characterized by early-onset demyelination sensory loss and skin ulceration. To the best of our knowledge, no cases of an autonomic disorder have been reported clearly in a patient with WNK/HSN2 gene mutation and only one case of a Japanese patient with the WNK/HSN2 gene mutation of HSAN type II was previously reported. CASE PRESENTATION: Here we describe a 54-year-old woman who had an early childhood onset of insensitivity to pain; superficial, vibration, and proprioception sensation disturbances; and several symptoms of autonomic failure (e...
October 21, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27746321/phenotypic-severity-of-autosomal-dominant-osteopetrosis-type-ii-ado2-mice-on-different-genetic-backgrounds-recapitulates-the-features-of-human-disease
#7
Imranul Alam, Amie K McQueen, Dena Acton, Austin M Reilly, Rita L Gerard-O'Riley, Dana K Oakes, Charishma Kasipathi, Abigail Huffer, Weston B Wright, Michael J Econs
Autosomal dominant osteopetrosis type II (ADO2) is a heritable osteosclerotic bone disorder due to dysfunctional osteoclast activity. ADO2 is caused by missense mutations in the chloride channel 7 (CLCN7) gene characterized by osteosclerosis with multiple fractures. ADO2 can result in osteomyelitis, visual loss and bone marrow failure. Currently, there is no cure for ADO2, and until recently no appropriate animal model of ADO2 existed to understand better the pathogenesis of this disease and to test new therapies...
January 2017: Bone
https://www.readbyqxmd.com/read/27714987/in-vitro-characterization-of-biofilms-formed-by-kingella-kingae
#8
Jeffrey B Kaplan, Vandana Sampathkumar, Meriem Bendaoud, Alexander K Giannakakis, Edward T Lally, Nataliya V Balashova
The Gram-negative bacterium Kingella kingae is part of the normal oropharyngeal mucosal flora of children under four years old. K. kingae can enter the submucosa and cause infections of the skeletal system in children including septic arthritis and osteomyelitis. The organism is also associated with infective endocarditis in children and adults. Although biofilm formation has been coupled with pharyngeal colonization, osteoarticular infections, and infective endocarditis, no studies have investigated biofilm formation in K...
October 7, 2016: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/27598583/effects-of-transpositional-muscle-flaps-transfected-with-vascular-endothelial-growth-factor-gene-in-the-treatment-of-experimental-osteomyelitis
#9
Mahir Aliyev, Andaç Aykan, Muhitdin Eski, Nuri Arslan, Bülent Kurt, Mustafa Şengezer
BACKGROUND: Based on the angiogenetic and stimulating effects of bone healing and formation of vascular endothelial growth factor (VEGF), the present study was designed to assess the efficacy of VEGF gene application in the management of experimentally induced osteomyelitis. METHODS: Thirty-two male Sprague Dawley rats were divided into 4 groups, and osteomyelitis was induced in the left tibial bones. Group 1 (n=8) was designated as a control group, and, after the induction of osteomyelitis, no treatment was applied for a period of 4 weeks...
May 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27573133/biodegradable-mg-cu-alloy-implants-with-antibacterial-activity-for-the-treatment-of-osteomyelitis-in%C3%A2-vitro-and-in%C3%A2-vivo-evaluations
#10
Yang Li, Lina Liu, Peng Wan, Zanjing Zhai, Zhenyang Mao, Zhengxiao Ouyang, Degang Yu, Qi Sun, Lili Tan, Ling Ren, Zhenan Zhu, Yongqiang Hao, Xinhua Qu, Ke Yang, Kerong Dai
Treatment of chronic osteomyelitis (bone infection) remains a clinical challenge; in particular, it requires an implantable material with improved antibacterial activity. Here, we prepared biodegradable magnesium (Mg)-copper (Cu) alloys with different Cu contents (0.05, 0.1, and 0.25 wt%) and assessed their potential for treating methicillin-resistant Staphylococcus aureus-induced osteomyelitis. We evaluated the microstructures, mechanical properties, corrosion behavior, and ion release of the alloys in vitro, and their biocompatibility and antibacterial activity in vitro and in vivo...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27495005/severe-chronic-osteomyelitis-caused-by-morganella-morganii-with-high-population-diversity
#11
Jialiang Zhu, Haifeng Li, Li Feng, Min Yang, Ronggong Yang, Lin Yang, Li Li, Ruoyan Li, Minshan Liu, Shuxun Hou, Yuehua Ke, Wenfeng Li, Fan Bai
A case of chronic osteomyelitis probably caused by Morganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population structure analysis of the isolates from the patient showed the bacterial population to be highly diverse. This case provides a valuable example of a long-term infection caused by an opportunistic pathogen, M. morganii, with high diversity, which might evolve during replication within the host...
September 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27492554/icariine-restores-lps-induced-bone-loss-by-downregulating-mir-34c-level
#12
Jian Liu, Danqing Li, Xuying Sun, Yuting Wang, Qiangbing Xiao, Anmin Chen
Bacteria-induced inflammatory responses cause excessive bone resorption in chronic inflammatory diseases such as septic arthritis, osteomyelitis, and orthopedic implant failure. Icariine has been reported to facilitate the bone healing and reduce the occurrence of osteoporosis in clinical, moreover, laboratory studies which have proved that Icariine promotes the proliferation and differentiation of osteoblasts in vitro. The present study aimed to evaluate the effects of Icariine on lipopolysaccharide (LPS)-induced bone loss via an osteogenic-in vitro model and to elucidate the underlying molecular mechanisms...
October 2016: Inflammation
https://www.readbyqxmd.com/read/27417195/diversity-of-escherichia-coli-strains-involved-in-vertebral-osteomyelitis-and-arthritis-in-broilers-in-brazil
#13
Juliana Fortes Vilarinho Braga, Nathalie Katy Chanteloup, Angélina Trotereau, Sylvie Baucheron, Rodrigo Guabiraba, Roselene Ecco, Catherine Schouler
BACKGROUND: Locomotor disorders and infections by Escherichia coli represent major concerns to the poultry industry worldwide. Avian pathogenic E. coli (APEC) is associated with extraintestinal infections leading to respiratory or systemic disease known as colibacillosis. The most common lesions seen in cases of colibacillosis are perihepatitis, airsacculitis, pericarditis, peritonitis/salpingitis and arthritis. These diseases are responsible for significant economic losses in the poultry industry worldwide...
July 14, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27406563/ctam-is-required-for-menaquinol-oxidase-aa3-function-in-staphylococcus-aureus
#14
Neal D Hammer, Lici A Schurig-Briccio, Svetlana Y Gerdes, Robert B Gennis, Eric P Skaar
UNLABELLED: Staphylococcus aureus is the leading cause of skin and soft tissue infections, bacteremia, osteomyelitis, and endocarditis in the developed world. The ability of S. aureus to cause substantial disease in distinct host environments is supported by a flexible metabolism that allows this pathogen to overcome challenges unique to each host organ. One feature of staphylococcal metabolic flexibility is a branched aerobic respiratory chain composed of multiple terminal oxidases...
2016: MBio
https://www.readbyqxmd.com/read/27399775/staphylococcus-aureus-toxins-and-diabetic-foot-ulcers-role-in-pathogenesis-and-interest-in-diagnosis
#15
REVIEW
Catherine Dunyach-Remy, Christelle Ngba Essebe, Albert Sotto, Jean-Philippe Lavigne
Infection of foot ulcers is a common, often severe and costly complication in diabetes. Diabetic foot infections (DFI) are mainly polymicrobial, and Staphylococcus aureus is the most frequent pathogen isolated. The numerous virulence factors and toxins produced by S. aureus during an infection are well characterized. However, some particular features could be observed in DFI. The aim of this review is to describe the role of S. aureus in DFI and the implication of its toxins in the establishment of the infection...
2016: Toxins
https://www.readbyqxmd.com/read/27356097/missense-splice-variant-g-20746a-g-p-ile183val-of-interferon-gamma-receptor-1-ifngr1-coincidental-with-mycobacterial-osteomyelitis-a-screen-of-osteoarticular-lesions
#16
Agnieszka Bińczak-Kuleta, Aleksander Szwed, Mark R Walter, Maciej Kołban, Andrzej Ciechanowicz, Jeremy S C Clark
Previously, dominant partial interferon-gamma receptor 1 (IFN-g-R1) susceptibility to environmental mycobacteria was found with IFNGR1 deletions or premature stop. Our aim was to search for IFNGR1 variants in patients with mycobacterial osteoarticular lesions. Biopsies from the patients were examined for acid-fast bacilli, inflammatory cell infiltration, and mycobacterial niacin. Mycobacterial rRNA was analyzed using a target-amplified rRNA probe test. Peripheral-blood-leukocyte genomic DNA was isolated from 19 patients using the QIAamp DNA Mini Kit, and all IFNGR1 exons were sequenced using an ABIPRISM 3130 device...
August 2, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27329975/association-of-vitamin-d-receptor-gene-taqi-bsmi-foki-and-apai-polymorphisms-and-susceptibility-to-extremity-chronic-osteomyelitis-in-chinese-population
#17
Nan Jiang, Xing-Qi Zhao, Cheng-He Qin, Yan-Jun Hu, Lei Wang, Guo-Ping Xie, Sheng-Nan Wang, Li-Guang Chen, Bin Yu
Previous studies have indicated that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with the risk of several inflammatory diseases. However, potential association of the VDR gene polymorphisms with susceptibility to extremity chronic osteomyelitis remains unclear. The present study aimed to investigate link between VDR gene polymorphisms and the risk of extremity chronic osteomyelitis in Chinese population. A total of 233 patients with chronic osteomyelitis and 200 healthy controls were genotyped for the 4 single-nucleotide polymorphisms (SNPs) (TaqI, BsmI, FokI and ApaI) in VDR gene using the SNaPshot genotyping method...
August 2016: Injury
https://www.readbyqxmd.com/read/27324766/staphylococcus-aureus-alpha-toxin-is-conserved-among-diverse-hospital-respiratory-isolates-collected-from-a-global-surveillance-study-and-is-neutralized-by-monoclonal-antibody-medi4893
#18
David E Tabor, Li Yu, Hoyin Mok, Christine Tkaczyk, Bret R Sellman, Yuling Wu, Vaheh Oganesyan, Tim Slidel, Hasan Jafri, Michael McCarthy, Patricia Bradford, Mark T Esser
Staphylococcus aureus infections lead to an array of illnesses ranging from mild skin infections to serious diseases, such endocarditis, osteomyelitis, and pneumonia. Alpha-toxin (Hla) is a pore-forming toxin, encoded by the hla gene, that is thought to play a key role in S. aureus pathogenesis. A monoclonal antibody targeting Hla, MEDI4893, is in clinical development for the prevention of S. aureus ventilator-associated pneumonia (VAP). The presence of the hla gene and Hla protein in 994 respiratory isolates collected from patients in 34 countries in Asia, Europe, the United States, Latin America, the Middle East, Africa, and Australia was determined...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27324764/repurposing-the-nonsteroidal-anti-inflammatory-drug-diflunisal-as-an-osteoprotective-antivirulence-therapy-for-staphylococcus-aureus-osteomyelitis
#19
Andrew S Hendrix, Thomas J Spoonmore, Aimee D Wilde, Nicole E Putnam, Neal D Hammer, Daniel J Snyder, Scott A Guelcher, Eric P Skaar, James E Cassat
Staphylococcus aureus osteomyelitis is a common and debilitating invasive infection of bone. Treatment of osteomyelitis is confounded by widespread antimicrobial resistance and the propensity of bacteria to trigger pathological changes in bone remodeling that limit antimicrobial penetration to the infectious focus. Adjunctive therapies that limit pathogen-induced bone destruction could therefore limit morbidity and enhance traditional antimicrobial therapies. In this study, we evaluate the efficacy of the U...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27323068/association-of-single-nucleotide-polymorphisms-in-pro-inflammatory-cytokine-and-toll-like-receptor-genes-with-pediatric-hematogenous-osteomyelitis
#20
A E Osman, M Mubasher, N E ElSheikh, H AlHarthi, M S AlZahrani, N Ahmed, G ElGhazali, B A Bradley, A-S A Fadil
Hematogenous osteomyelitis (HO) is a bone infection wherein bacteria penetrate to the bone through the blood stream. Several single nucleotide polymorphisms (SNPs) have been associated with susceptibility to infectious diseases. In this study, we investigated the contribution of SNPs in interleukin (IL)-1B1 (rs16944), IL1A (rs1800587), IL1B (rs1143634), toll-like receptor (TLR)-2 (rs3804099), TLR4 (rs4986790), TLR4 (rs4986791), IL1R (rs2234650), tumor necrosis factor (TNF)-α (rs1800629), TNF (rs361525), and IL1RN (rs315952) towards the development of HO in Saudi patients and compared to healthy controls...
2016: Genetics and Molecular Research: GMR
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