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https://www.readbyqxmd.com/read/28085119/transgenic-tobacco-expressing-the-tat-helicokinin-i-cpti-fusion-protein-show-increased-resistance-and-toxicity-to-helicoverpa-armigera-lepidoptera-noctuidae
#1
Zhou Zhou, Yongli Li, Chunyan Yuan, Yongan Zhang, Liangjian Qu
Insect kinins were shown to have diuretic activity, inhibit weight gain, and have antifeedant activity in insects. In order to study the potential of the TAT-fusion approach to deliver diuretic peptides per os to pest insects, the HezK I peptide from Helicoverpa zea, as a representative of the kinin family, was selected. The fusion gene TAT-HezK I was designed and was used to transform tobacco plants. As a means to further improve the stability of TAT-HezK I, a fusion protein incorporating HezK I, transactivator of transcription (TAT), and the cowpea trypsin inhibitor (CpTI) was also designed...
January 12, 2017: Genes
https://www.readbyqxmd.com/read/28078811/the-effects-of-nanomaterials-on-blood-coagulation-in-hemostasis-and-thrombosis
#2
REVIEW
Jan Simak, Silvia De Paoli
The blood coagulation balance in the organism is achieved by the interaction of the blood platelets (PLTs) with the plasma coagulation system (PCS) and the vascular endothelial cells. In healthy organism, these systems prevent thrombosis and, in events of vascular damage, enable blood clotting to stop bleeding. The dysregulation of hemostasis may cause serious thrombotic and/or hemorrhagic pathologies. Numerous engineered nanomaterials are being investigated for biomedical purposes and are unavoidably exposed to the blood...
January 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28066096/pain-on-propofol-injection-causes-and-remedies
#3
REVIEW
Kalindi Anil Desousa
Pain on propofol injection (POPI) is a minor problem that all anesthetists face every day. Introduction of several new formulations and hundreds of clinical trials have failed to find its remedy with just one intervention in all patients. This article highlights the causes of POPI and interventions that are used to eliminate this pain in current practice. Relevant articles from Medline and Embase databases were searched and included in this descriptive review with the following conclusions: (1) POPI is due to irritation of venous adventitia leading to release of mediators such as kininogen from kinin cascade...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28065968/therapeutic-uses-of-pineapple-extracted-bromelain-in-surgical-care-a-review
#4
Zehra Abdul Muhammad, Tashfeen Ahmad
Bromelain is an extract obtained from the pineapple plant and is used as a traditional folk remedy for several ailments. In this review, a comprehensive electronic database search was carried out to compile available literature on therapeutic implications of bromelain. Pharmaceutical value of bromelain has been demonstrated in different surgical sub-specialties. Diverse biological processes like anti-inflammatory, anti-oedematous, analgesic, anti-thrombotic, exfoliation etc. are involved in bromelain's therapeutic actions, mediated through the kallikrein-kinin and arachidonic acid pathways as well as through effects on cell mediated immunity...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28003079/leukocyte-derived-microvesicles-dock-on-glomerular-endothelial-cells-stardust-in-the-kidney
#5
Matthias Mack
Microvesicles are released from the plasma membrane of various cell types, can be taken up by other cells, and can transport membrane proteins and cytosolic contents between cells. Kahn et al. demonstrate that leukocyte-derived microvesicles bearing B1-kinin receptors are enriched in the plasma of vasculitis patients and dock on endothelial cells in the glomerulus. Cell culture experiments suggest that B1-receptors transferred by these microvesicles are functionally active on acceptor cells.
January 2017: Kidney International
https://www.readbyqxmd.com/read/28002223/is-there-a-role-for-inflammation-in-contact-lens-discomfort
#6
Mark D P Willcox
PURPOSE: The aim of this study was to examine the literature with respect to inflammation of the ocular surface and the presence of inflammatory mediators in the tear film during contact lens wear. METHODS: The literature on contact lens discomfort that relates to signs of inflammation was searched. Reference was paid to the cardinal signs of inflammation (pain, heat, redness, and swelling) as well as the appearance of inflammatory mediators in the tear film during contact lens wear...
January 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/27999472/carbamazepine-induced-angioedema
#7
Ansha Subramanian, Mangaiarkkarasi Adhimoolam, Senthil Gopalakrishnan, Meher Ali Rajamohammed
Angioedema is a rare adverse reaction of carbamazepine, which causes localized tissue edema in submucosal and subcutaneous tissue mediated by histamine, serotonin, and kinins (bradykinin). We report a case of 34-year-old female who developed angioedema, 24 h after administration of carbamazepine for treating bipolar disorder. Patient's symptoms responded rapidly with antihistamine therapy and with the withdrawal of carbamazepine, the offending drug. Carbamazepine-induced angioedema is a life-threatening reaction which requires immediate treatment and monitoring in order to avoid morbidity and mortality...
September 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27990282/the-complement-system-an-evolution-in-progress
#8
REVIEW
Berhane Ghebrehiwet
The complement system, which consists of three independent but interacting pathways, constitutes a powerful arm of innate immunity. Its major function is to recognize and destroy pathogenic microorganisms as well as eliminate modified self-antigens. Although it is a fine-tuned system with innate capacity to discriminate self from non-self as well as danger from non-danger signals, an unwarranted activation can nonetheless occur and cause tissue destruction. To prevent such activation, specific regulators present both in plasma and on the cell surface tightly control it...
2016: F1000Research
https://www.readbyqxmd.com/read/27988430/kinin-receptors-key-regulators-of-autoimmunity
#9
REVIEW
Rafael Cypriano Dutra
The central function of the immune system is to protect the host from environmental agents such as microbes or chemicals, thereby preserving the integrity of the body, and preventing the onset of illness and infection. Moreover, the immune system is constantly challenged to discriminate self vs. non-self and mediate the correct response, a phenomenon called self-tolerance. The failure of mechanisms responsible for self-tolerance and induction of an immune response against components of the self, induces autoimmunity and culminates however, in several autoimmune diseases...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27984711/evaluation-of-anaphylactoid-constituents-in-vitro-and-in-vivo
#10
Yubin Xu, Chunyan Liu, Deqiang Dou, Qiuhong Wang
Natural medicine injections have been widely used in clinics, while adverse reaction reports also have increased rapidly in recent years. To examine the anaphylactoid constituents of natural medicine injections, RBL-2H3 cell degranulation and human serum complement activation models were used to screen the anaphylactoid constituents, and the BN rat model was used to explore the anaphylactoid mechanism of these constituents. The result of an in vitro study showed that the individual compounds of natural medicine injections (chlorogenic acid, hyodeoxycholic acid, cholalic acid, ginkgolic acid, phillyrin, schisandrin B, schisandrin A, puerarin, and tanshinone IIA) and polysaccharide could not induce RBL-2H3 to release histamine and β-hexosaminidase, while proteins Tween-80 and tannic acid were the main anaphylactoid constituents in the natural medicine injections...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27965959/a-novel-antithrombotic-mechanism-mediated-by-the-receptors-of-the-kallikrein-kinin-and-renin-angiotensin-systems
#11
REVIEW
Alvin H Schmaier
The contact activation (CAS) and kallikrein/kinin (KKS) systems regulate thrombosis risk in two ways. First, the CAS influences contact activation-induced factor XI activation and thrombin formation through the hemostatic cascade. Second, prekallikrein (PK) and bradykinin of the KKS regulate expression of three vessel wall G-protein-coupled receptors, the bradykinin B2 receptor (B2R), angiotensin receptor 2, and Mas to influence prostacyclin formation. The degree of intravascular prostacyclin formation inversely regulates intravascular thrombosis risk...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27960614/long-term-individual-shear-rate-therapy-counterpulsation-enhances-plasma-nitrite-release-in-patients-with-pad
#12
Michèle Brix, Eva-Elina Buschmann, Andreas Zietzer, Jonnel Anthony Jaurigue, Lulu Li, Constantin Jungk, Ivo Buschmann, Doreen Janke, Philipp Hillmeister
BACKGROUND: Individual shear rate therapy (ISRT) has been designed as a novel non-invasive treatment option for peripheral artery disease (PAD) patients and has been shown to improve endothelial function and walking distance. The aim of this study was to elucidate the impact of ISRT on the level of nitric oxide in patient blood plasma and the expression of related molecular markers in peripheral blood mononuclear cells (PBMCs). Molecular diagnostic tests were performed for two ISRT trials...
December 14, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27925683/inorganic-polyphosphate-a-key-modulator-of-inflammation
#13
REVIEW
Seyed Mahdi Hassanian, Amir Avan, Abdolreza Ardeshirylajimi
Inorganic polyphosphate (PolyP) is a molecule with prothrombotic and proinflammatory properties in blood. PolyP activates the NF-κB signaling pathway, increases the expression of cell surface adhesion molecules and disrupts the vascular barrier integrity of endothelial cells. PolyP-induced NF-κB activation and vascular hyperpermeability are regulated by the mTORC1 and mTORC2 pathways, respectively. Through interaction with RAGE and P2Y1 receptors, PolyP dramatically amplifies the proinflammatory responses of nuclear proteins...
December 7, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27924789/kallikrein-kinin-system-is-it-the-fountain-of-youth
#14
Giulio Garaffa, Fabio Castiglione
No abstract text is available yet for this article.
December 2, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27923785/genetic-determination-of-the-vascular-reactions-in-humans-in-response-to-the-diving-reflex
#15
Tatiana I Baranova, Dmitrii N Berlov, Oleg S Glotov, Ekaterina A Korf, Alexey D Minigalin, Alla V Mitrofanova, Ildus I Ahmetov, Andrey S Glotov
The purpose of this study was to investigate the genetic mechanisms of the defense vascular reactions in response to the diving reflex in humans with polymorphisms in the genes ADBR2, ACE, AGTR1, BDKRB2, and REN. We hypothesized that protective vascular reactions, in response to the diving reflex, are genetically determined and are distinguished in humans with gene polymorphisms of the renin-angiotensin and kinin-bradykinin system. A total of 80 subjects (19±1.4 years) participated in the study. The intensity of the vascular response was estimated using photopletismogram...
December 6, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27919002/inhibitory-effect-of-fentanyl-citrate-on-the-release-of-endothlin-1-induced-by-bradykinin-in-melanoma-cells
#16
Tsugunobu Andoh, Akira Shinohara, Yasushi Kuraishi
BACKGROUND: Our previous study showed that the μ-opioid receptor agonist fentanyl citrate inhibits endothelin-1-and bradykinin-mediated pain responses in mice orthotopically inoculated with melanoma cells. We also demonstrated that bradykinin induces endothelin-1 secretion in melanoma cells. However, the analgesic mechanisms of fentanyl citrate remain unclear. Thus, the present study was conducted to determine whether fentanyl citrate affects bradykinin-induced endothelin-1 secretion in B16-BL6 melanoma cells...
February 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27914700/microvesicle-transfer-of-kinin-b1-receptors-is-a-novel-inflammatory-mechanism-in-vasculitis
#17
Robin Kahn, Maria Mossberg, Anne-Lie Ståhl, Karl Johansson, Ingrid Lopatko Lindman, Caroline Heijl, Mårten Segelmark, Matthias Mörgelin, L M Fredrik Leeb-Lundberg, Diana Karpman
During vasculitis, activation of the kinin system induces inflammation, whereby the kinin B1-receptor is expressed and activated after ligand binding. Additionally, activated blood cells release microvesicles into the circulation. Here we determined whether leukocyte-derived microvesicles bear B1-kinin receptors during vasculitis, and if microvesicles transfer functional B1-receptors to recipient cells, thus promoting inflammation. By flow cytometry, plasma from patients with vasculitis were found to contain high levels of leukocyte-derived microvesicles bearing B1-receptors...
January 2017: Kidney International
https://www.readbyqxmd.com/read/27867935/processing-of-factor-xii-during-inflammatory-reactions
#18
REVIEW
Bernard Nico Jukema, Steven de Maat, Coen Maas
The contact system was originally identified as an obsolete part of the coagulation system, but it has been repeatedly implicated in inflammatory states, such as infection, as well as in allergic- and chronic inflammatory disease. Under these conditions, there is surprisingly little evidence that factor XII (FXII) acts as a coagulation factor, and its activity appears to be mainly directed toward activation of the kallikrein-kinin system. The contact system factors interact with pathogens as well as cells of the (innate) immune system on several levels...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27858843/association-of-the-klk1-rs5516-g-allele-and-the-ace-d-allele-with-aortic-aneurysm-and-atherosclerotic-stenosis
#19
Yiming Zhang, Hongliang Huang, Yuliang Ma, Yifeng Sun, Guohua Wang, Liming Tang
OBJECTIVE: Atherosclerosis underlies aortic aneurysm (AA) and atherosclerotic stenosis (AS). Kallikrein-1 (KLK1) and angiotensin-converting enzyme (ACE) are 2 key molecules in kallikrein-kinin systems and renin-angiotensin systems, respectively, which are responsible for maintaining vascular balance and stability, playing important roles in atherosclerosis. We aimed to assess the involvement of single nucleotide polymorphism rs5516 in KLK1 as well as the insertion/deletion rs4646994 polymorphism in ACE in the development of AA and AS...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27848207/primary-role-for-kinin-b1-and-b2-receptors-in-glioma-proliferation
#20
Natália Fontana Nicoletti, Jacques Sénécal, Vinicius Duval da Silva, Marcelo R Roxo, Nelson Pires Ferreira, Rafael Leite T de Morais, João Bosco Pesquero, Maria Martha Campos, Réjean Couture, Fernanda Bueno Morrone
This study investigated the role of kinins and their receptors in malignant brain tumors. As a first approach, GL-261 glioma cells were injected (2 × 10(5) cells in 2 μl/2 min) into the right striatum of adult C57/BL6 wild-type, kinin B1 and B2 receptor knockout (KOB1R and KOB2R) and B1 and B2 receptor double knockout mice (KOB1B2R). The animals received the selective B1R (SSR240612) and/or B2R (HOE-140) antagonists by intracerebroventricular (i.c.v.) route at 5, 10, and 15 days. The tumor size quantification, mitotic index, western blot analysis, quantitative autoradiography, immunofluorescence, and confocal microscopy were carried out in brain tumor samples, 20 days after tumor induction...
November 16, 2016: Molecular Neurobiology
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