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https://www.readbyqxmd.com/read/27867935/processing-of-factor-xii-during-inflammatory-reactions
#1
REVIEW
Bernard Nico Jukema, Steven de Maat, Coen Maas
The contact system was originally identified as an obsolete part of the coagulation system, but it has been repeatedly implicated in inflammatory states, such as infection, as well as in allergic- and chronic inflammatory disease. Under these conditions, there is surprisingly little evidence that factor XII (FXII) acts as a coagulation factor, and its activity appears to be mainly directed toward activation of the kallikrein-kinin system. The contact system factors interact with pathogens as well as cells of the (innate) immune system on several levels...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27858843/association-of-the-klk1-rs5516-g-allele-and-the-ace-d-allele-with-aortic-aneurysm-and-atherosclerotic-stenosis
#2
Yiming Zhang, Hongliang Huang, Yuliang Ma, Yifeng Sun, Guohua Wang, Liming Tang
OBJECTIVE: Atherosclerosis underlies aortic aneurysm (AA) and atherosclerotic stenosis (AS). Kallikrein-1 (KLK1) and angiotensin-converting enzyme (ACE) are 2 key molecules in kallikrein-kinin systems and renin-angiotensin systems, respectively, which are responsible for maintaining vascular balance and stability, playing important roles in atherosclerosis. We aimed to assess the involvement of single nucleotide polymorphism rs5516 in KLK1 as well as the insertion/deletion rs4646994 polymorphism in ACE in the development of AA and AS...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27848207/primary-role-for-kinin-b1-and-b2-receptors-in-glioma-proliferation
#3
Natália Fontana Nicoletti, Jacques Sénécal, Vinicius Duval da Silva, Marcelo R Roxo, Nelson Pires Ferreira, Rafael Leite T de Morais, João Bosco Pesquero, Maria Martha Campos, Réjean Couture, Fernanda Bueno Morrone
This study investigated the role of kinins and their receptors in malignant brain tumors. As a first approach, GL-261 glioma cells were injected (2 × 10(5) cells in 2 μl/2 min) into the right striatum of adult C57/BL6 wild-type, kinin B1 and B2 receptor knockout (KOB1R and KOB2R) and B1 and B2 receptor double knockout mice (KOB1B2R). The animals received the selective B1R (SSR240612) and/or B2R (HOE-140) antagonists by intracerebroventricular (i.c.v.) route at 5, 10, and 15 days. The tumor size quantification, mitotic index, western blot analysis, quantitative autoradiography, immunofluorescence, and confocal microscopy were carried out in brain tumor samples, 20 days after tumor induction...
November 16, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27848184/the-initiation-and-effects-of-plasma-contact-activation-an-overview
#4
Lisha Lin, Mingyi Wu, Jinhua Zhao
The plasma contact system sits atop the intrinsic coagulation cascade and plasma kallikrein-kinin pathway, and in vivo its activation contributes, respectively, to coagulation and inflammation mainly via two downstream pathways. This system has been widely investigated, its activation mechanisms by negatively charged surfaces and the interactions within its components, factor XII, prekallikrein and high molecular weight kininogen are well understood at the biochemical level. However, as most of the activators that have been discovered by in vitro experiments are exogenous, the physiological activators and roles of the contact system have remained unclear and controversial...
November 15, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27844290/potentiation-of-paclitaxel-induced-pain-syndrome-in-mice-by-angiotensin-i-converting-enzyme-inhibition-and-involvement-of-kinins
#5
Indiara Brusco, Cássia Regina Silva, Gabriela Trevisan, Camila de Campos Velho Gewehr, Flávia Karine Rigo, Lidia La Rocca Tamiozzo, Mateus Fortes Rossato, Raquel Tonello, Gerusa Duarte Dalmolin, Daniela de Almeida Cabrini, Marcus Vinícius Gomez, Juliano Ferreira, Sara Marchesan Oliveira
Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin receptor signalling. The goal of this study was to evaluate the role of kinins on paclitaxel-associated acute pain syndromes (P-APS) and the effect of ACE inhibition on P-APS and paclitaxel-associated chronic peripheral neuropathy (P-CPN) in mice...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27834692/factor-xii-as-a-therapeutic-target-in-thromboembolic-and-inflammatory-diseases
#6
REVIEW
Katrin F Nickel, Andy T Long, Tobias A Fuchs, Lynn M Butler, Thomas Renné
Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form (FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from FXII's unique mechanism of activation that is induced by binding (contact) to negatively charged surfaces. Various substances have the capacity to trigger FXII contact-activation in vivo including mast cell-derived heparin, misfolded protein aggregates, collagen, nucleic acids, and polyphosphate. FXII deficiency is not associated with bleeding, and for decades, the factor was considered to be dispensable for coagulation in vivo...
November 10, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27831591/new-genetic-association-for-the-kinin-system-the-l-arginine-connection-insight-association-of-l-arginine-levels-and-two-loci-in-genes-of-the-kallikrein-kinin-system
#7
Pablo García de Frutos, José Martínez-González
No abstract text is available yet for this article.
November 30, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27823962/the-transient-receptor-potential-ankyrin-1-mediates-mechanical-hyperalgesia-induced-by-the-activation-of-b1-receptor-in-mice
#8
Flavia Carla Meotti, Cláudia Pinto Figueiredo, Marianne Manjavachi, João B Calixto
The kinin receptor B1 and the transient receptor potential ankyrin 1 (TRPA1) work as initiators and gatekeepers of nociception and inflammation. This study reports that the nociceptive transmission induced by activation of B1 receptor is dependent on TRPA1 ion channel. The mechanical hyperalgesia was induced by intrathecal (i.t.) injection of B1 agonist des-Arginine(9)-bradykinin (DABK) or TRPA1 agonist cinnamaldehyde and was evaluated by the withdrawal response after von Frey Hair application in the hind paw...
November 4, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27814401/the-kallikrein-kinin-system-a-novel-mediator-of-il-17-driven-anti-candida-immunity-in-the-kidney
#9
Kritika Ramani, Abhishek V Garg, Chetan V Jawale, Heather R Conti, Natasha Whibley, Edwin K Jackson, Sruti S Shiva, William Horne, Jay K Kolls, Sarah L Gaffen, Partha S Biswas
The incidence of life-threatening disseminated Candida albicans infections is increasing in hospitalized patients, with fatalities as high as 60%. Death from disseminated candidiasis in a significant percentage of cases is due to fungal invasion of the kidney, leading to renal failure. Treatment of candidiasis is hampered by drug toxicity, the emergence of antifungal drug resistance and lack of vaccines against fungal pathogens. IL-17 is a key mediator of defense against candidiasis. The underlying mechanisms of IL-17-mediated renal immunity have so far been assumed to occur solely through the regulation of antimicrobial mechanisms, particularly activation of neutrophils...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27802438/bradykinin-contributes-to-sympathetic-and-pressor-responses-evoked-by-activation-of-skeletal-muscle-afferents-p2x-in-heart-failure
#10
Jihong Xing, Jianhua Li
BACKGROUND/AIMS: Published data suggest that purinergic P2X receptors of muscle afferent nerves contribute to the enhanced sympathetic nervous activity (SNA) and blood pressure (BP) responses during static exercise in heart failure (HF). In this study, we examined engagement of bradykinin (BK) in regulating responses of SNA and BP evoked by P2X stimulation in rats with HF. We further examined cellular mechanisms responsible for BK. We hypothesized that BK potentiates P2X currents of muscle dorsal root ganglion (DRG) neurons, and this effect is greater in HF due to upregulation of BK kinin B2 and P2X3 receptor...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27800486/first-report-of-eurycoma-longifolia-jack-root-extract-causing-relaxation-of-aortic-rings-in-rats
#11
Bae Huey Tee, See Ziau Hoe, Swee Hung Cheah, Sau Kuen Lam
Although Eurycoma longifolia has been studied for erectile function, the blood pressure- (BP-) lowering effect has yet to be verified. Hence, this study aims at investigating the BP-lowering properties of the plant with a view to develop an antihypertensive agent that could also preserve erectile function. Ethanolic root extract was partitioned by hexane, dichloromethane (DCM), ethyl acetate, butanol, and water. The DCM fraction, found to be potent in relaxing phenylephrine- (PE-) precontracted rat aortic rings, was further purified by column chromatography...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27782339/the-complement-and-contact-activation-systems-partnership-in-pathogenesis-beyond-angioedema
#12
REVIEW
Berhane Ghebrehiwet, Allen P Kaplan, Kusumam Joseph, Ellinor I B Peerschke
The blood plasma contains four biologically important proteolytic cascades, which probably evolved from the same ancestral gene. This in part may explain why each cascade has very similar "initiating trigger" followed by sequential and cascade-like downstream enzymatic activation pattern. The four cascades are: the complement system, the blood clotting cascade, the fibrinolytic system, and the kallikrein-kinin system. Although much has been written about the interplay between all these enzymatic cascades, the cross-talk between the complement and the kinin generating systems has become particularly relevant as this interaction results in the generation of nascent molecules that have significant impact in various inflammatory diseases including angioedema and cancer...
November 2016: Immunological Reviews
https://www.readbyqxmd.com/read/27782319/dangerous-liaisons-complement-coagulation-and-kallikrein-kinin-cross-talk-act-as-a-linchpin-in-the-events-leading-to-thromboinflammation
#13
REVIEW
Kristina N Ekdahl, Yuji Teramura, Osama A Hamad, Sana Asif, Claudia Duehrkop, Karin Fromell, Elisabet Gustafson, Jaan Hong, Huda Kozarcanin, Peetra U Magnusson, Markus Huber-Lang, Peter Garred, Bo Nilsson
Innate immunity is fundamental to our defense against microorganisms. Physiologically, the intravascular innate immune system acts as a purging system that identifies and removes foreign substances leading to thromboinflammatory responses, tissue remodeling, and repair. It is also a key contributor to the adverse effects observed in many diseases and therapies involving biomaterials and therapeutic cells/organs. The intravascular innate immune system consists of the cascade systems of the blood (the complement, contact, coagulation, and fibrinolytic systems), the blood cells (polymorphonuclear cells, monocytes, platelets), and the endothelial cell lining of the vessels...
November 2016: Immunological Reviews
https://www.readbyqxmd.com/read/27782318/the-emerging-roles-of-mannose-binding-lectin-associated-serine-proteases-masps-in-the-lectin-pathway-of-complement-and-beyond
#14
REVIEW
József Dobó, Gábor Pál, László Cervenak, Péter Gál
Mannose-binding lectin (MBL)-associated serine proteases (MASPs) are the enzymatic constituents of the lectin pathway of the complement system. They are complexed with large pattern recognition molecules (PRMs) such as MBL, other collectins, and ficolins. The main function of two of the three MASPs has crystallized lately: MASP-1 autoactivates first, then it activates MASP-2, and finally both participate in the formation of the C4b2a convertase. In addition to this, both enzymes are involved in several other processes which are subject to intense research nowadays...
November 2016: Immunological Reviews
https://www.readbyqxmd.com/read/27758702/cellular-and-molecular-mechanisms-of-diuretic-plants-an-overview
#15
Francislaine Aparecida Lívero, Jacqueline Vergutz Menetrier, Emerson Luiz Botelho Lourenço, Arquimedes Gasparotto Junior
Heart failure, hypertension, cirrhosis and nephritic syndrome are among conditions that alter volume and composition of body fluids and are modulated by diuretics. Natural products are important source of diuretics and have been considered remarkable alternative with greater effectiveness and fewer side effects. However, many of these plants used in traditional medicine must be scientifically assessed about their efficacy and toxicity. Despite the large number of published articles claiming that plants or plant-derived components may act as diuretic agents, few studies have addressed the mechanism of action of medicinal plants...
October 14, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27756949/b1-kinin-receptors-modulate-mesobuthus-tamulus-venom-induced-vasosensory-reflex-responses-in-anesthetized-rats
#16
Sanjeev K Singh, Shripad B Deshpande
OBJECTIVE: Intra-arterial injection of Mesobuthus tamulus (BT) venom produces reflex vasosensory responses modulating cardiorespiratory parameters in albino rats. The present study was conducted to understand the role of kinin receptors in modulating vasosensory reflexes evoked by BT venom. MATERIALS AND METHODS: In urethane-anesthetized rats, tracheostomy was performed to keep the airway patent. The femoral artery was cannulated proximally, as well as distally, to record the blood pressure (BP) and to inject the chemicals, respectively...
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27754186/sp-04-1-the-role-of-natriuretic-peptides-in-the-pathogenesis-of-cardiovascular-diseases
#17
Zhanna Kobalava
The burden of cardiovascular diseases (CVD) in general and heart failure (HF) in particular continues to increase worldwide. CVD are major contributors to death and morbidity and recognized as important drivers of healthcare expenditure. Chronic overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in human hypertension and HF pathophysiology. RAAS is fundamental in the overall regulation of cardiovascular homeostasis through the actions of hormones, which regulate vascular tone, and specifically blood pressure through vasoconstriction and renal sodium and water retention...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749899/analgesic-effect-of-photobiomodulation-on-bothrops-moojeni-venom-induced-hyperalgesia-a-mechanism-dependent-on-neuronal-inhibition-cytokines-and-kinin-receptors-modulation
#18
Nikele Nadur-Andrade, Camila Squarzoni Dale, Victoria Regina da Silva Oliveira, Elaine Flamia Toniolo, Regiane Dos Santos Feliciano, José Antonio da Silva, Stella Regina Zamuner
BACKGROUND: Envenoming induced by Bothrops snakebites is characterized by drastic local tissue damage that involves an intense inflammatory reaction and local hyperalgesia which are not neutralized by conventional antivenom treatment. Herein, the effectiveness of photobiomodulation to reduce inflammatory hyperalgesia induced by Bothrops moojeni venom (Bmv), as well as the mechanisms involved was investigated. METHODOLOGY/PRINCIPAL FINDINGS: Bmv (1 μg) was injected through the intraplantar route in the right hind paw of mice...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27732900/ts14-from-tityus-serrulatus-boosts-angiogenesis-and-attenuates-inflammation-and-collagen-deposition-in-sponge-induced-granulation-tissue-in-mice
#19
Puebla Cassini-Vieira, Mariane Felipetto, Leandro Barbosa Prado, Thiago Verano-Braga, Silvia Passos Andrade, Robson A S Santos, Mauro Martins Teixeira, Maria Elena de Lima, Adriano M C Pimenta, Luciola Silva Barcelos
We have previously described a 25mer anti-hypertensive peptide, previously named TsHpt-I (Tityus serrulatus Hypotensin-I), now Ts14, as an agonist of B2 kinin receptor. Bradykinin is known to play physiological roles in angiogenic, inflammatory, and fibrogenic processes, mostly mediated by B2 receptor. Therefore, we investigated whether Ts14 could modulate key events (neovascularization, inflammatory cell recruitment, and extracellular matrix deposition) of the fibrovascular tissue, induced by polyether-polyurethane sponge implants in mice...
October 11, 2016: Peptides
https://www.readbyqxmd.com/read/27721576/kinin-peptides-enhance-inflammatory-and-oxidative-responses-promoting-apoptosis-in-a-parkinson-s-disease-cellular-model
#20
Anna Niewiarowska-Sendo, Andrzej Kozik, Ibeth Guevara-Lora
Kinin peptides ubiquitously occur in nervous tissue and participate in inflammatory processes associated with distinct neurological disorders. These substances have also been demonstrated to promote the oxidative stress. On the other hand, the importance of oxidative stress and inflammation has been emphasized in disorders that involve the neurodegenerative processes such as Parkinson's disease (PD). A growing number of reports have demonstrated the increased expression of kinin receptors in neurodegenerative diseases...
2016: Mediators of Inflammation
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