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https://www.readbyqxmd.com/read/28926065/isomerisation-reactivity-and-coordination-chemistry-of-a-new-hybrid-multi-functional-phosphazane
#1
Alex J Plajer, Kevin Bold, Felix J Rizzuto, Raúl García-Rodríguez, Tanya K Ronson, Dominic S Wright
The unsymmetric P(III)/P(V) cyclodiphosphazane framework [(S[double bond, length as m-dash])(H)P(μ-N(t)Bu)2PNH(t)Bu] (2) provides entry into the mixed chalgogenide dianion [(S)P(μ-N(t)Bu)2P(Se)N(t)Bu](2-), and unique insight into the mechanisms of cis/trans isomerism in phosph(iii)- and phosph(v)-azanes.
September 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28923276/rapid-whole-brain-resting-state-fmri-at-3%C3%A2-tesla-efficiency-optimized-three-dimensional-epi-versus-repetition-time-matched-simultaneous-multi-slice-epi
#2
Rüdiger Stirnberg, Willem Huijbers, Daniel Brenner, Benedikt A Poser, Monique Breteler, Tony Stöcker
State-of-the-art simultaneous-multi-slice (SMS-)EPI and 3D-EPI share several properties that benefit functional MRI acquisition. Both sequences employ equivalent parallel imaging undersampling with controlled aliasing to achieve high temporal sampling rates. As a volumetric imaging sequence, 3D-EPI offers additional means of acceleration complementary to 2D-CAIPIRINHA sampling, such as fast water excitation and elliptical sampling. We performed an application-oriented comparison between a tailored, six-fold CAIPIRINHA-accelerated 3D-EPI protocol at 530 ms temporal and 2...
September 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28922510/effects-of-spatial-smoothing-on-functional-brain-networks
#3
Tuomas Alakörkkö, Heini Saarimäki, Enrico Glerean, Jari Saramäki, Onerva Korhonen
Graph-theoretical methods have rapidly become a standard tool in studies of the structure and function of the human brain. Whereas the structural connectome can be fairly straightforwardly mapped onto a complex network, there are more degrees of freedom in constructing networks that represent functional connections between brain areas. For fMRI data, such networks are typically built by aggregating the BOLD signal time series of voxels into larger entities (such as Regions of Interest in some brain atlas), and determining their connection strengths from some measure of time-series correlations...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28917813/structural-impacts-on-the-timing-and-amplitude-of-the-negative-bold-response
#4
David Provencher, Alexandre Bizeau, Guillaume Gilbert, Yves Bérubé-Lauzière, Kevin Whittingstall
The positive (PBR) and negative BOLD responses (NBR) arising in task-fMRI display varying magnitudes and dynamics across voxels. While the effects of structure, particularly of veins, on the PBR have been studied, little is known of NBR-structure relationships. Like the PBR, the NBR is often used as a surrogate marker of neuronal activation in both basic and clinical research and assessing its relationship with cortical structure may help interpret group differences. We therefore investigated how local structure affects BOLD amplitude and timing in PBR and NBR areas using multi-band fMRI during visual stimulation to obtain high temporal resolution (TR=0...
September 13, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28915853/low-threshold-unmyelinated-mechanoafferents-can-modulate-pain
#5
Kathrin Habig, Anne Schänzer, Wolfgang Schirner, Gothje Lautenschläger, Benjamin Dassinger, Håkan Olausson, Frank Birklein, Elke R Gizewski, Heidrun H Krämer
BACKGROUND: Human, hairy skin contains a subgroup of C-fibers, the C-low threshold mechanoreceptive afferents ((C-LTMR) C-tactile or C-touch (CT) fibers) that are linked with the signaling of affective aspects of human touch. Recent studies suggest an involvement of these afferents in the modulation of pain in healthy volunteers. Small fiber neuropathy (SFN) is associated with a damage of C-fibers. Therefore, an impairment of C-LTMRs can be assumed. We aimed to elaborate a possible role of CT-afferents in pain modulation by investigating healthy volunteers and SFN-patients...
September 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28914607/cortex-wide-bold-fmri-activity-reflects-locally-recorded-slow-oscillation-associated-calcium-waves
#6
Miriam Schwalm, Florian Schmid, Lydia Wachsmuth, Hendrik Backhaus, Andrea Kronfeld, Felipe Aedo Jury, Pierre-Hugues Prouvot, Consuelo Fois, Franziska Albers, Timo van Alst, Cornelius Faber, Albrecht Stroh
Spontaneous slow oscillation-associated slow wave activity represents an internally generated state which is characterized by alternations of network quiescence and stereotypical episodes of neuronal activity - slow wave events. However, it remains unclear which macroscopic signal is related to these active periods of the slow wave rhythm. We used optic fiber-based calcium recordings of local neural populations in cortex and thalamus to detect neurophysiologically defined slow calcium waves in isoflurane anesthetized rats...
September 15, 2017: ELife
https://www.readbyqxmd.com/read/28913727/sleep-amount-differentially-affects-fear-processing-neural-circuitry-in-pediatric-anxiety-a-preliminary-fmri-investigation
#7
Christina O Carlisi, Kevin Hilbert, Amanda E Guyer, Monique Ernst
Insufficient sleep, as well as the incidence of anxiety disorders, both peak during adolescence. While both conditions present perturbations in fear-processing-related neurocircuitry, it is unknown whether these neurofunctional alterations directly link anxiety and compromised sleep in adolescents. Fourteen anxious adolescents (AAs) and 19 healthy adolescents (HAs) were compared on a measure of sleep amount and neural responses to negatively valenced faces during fMRI. Group differences in neural response to negative faces emerged in the dorsal anterior cingulate cortex (dACC) and the hippocampus...
September 14, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28913561/conformational-rearrangement-of-1-2-d-gg-intrastrand-cis-diammineplatinum-crosslinked-dna-is-driven-by-counter-ion-penetration-within-the-minor-groove-of-the-modified-site
#8
Tsvetan G Gantchev, Peicho St Petkov, Darel J Hunting
The major structural aberrations of DNA induced by a cis-diammineplatinum (II) 1,2-d(GG) intrastrand cross-link (CPT) have been known for decades. To gain deeper insights into the structural dynamics of the sequence-dependent DNA distortions adjacent to the CPT adduct, we employed molecular modeling and molecular dynamics (MD) simulations. The structural dynamics of native (N-DNA) and cisPt 1,2-d(GG) crosslinked (CPT-DNA) in the form of symmetric 36 nt d(G2T15G*G*T15G2)●C2A15CCA15C2) oligonucleotide duplexes is compared...
September 14, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28913163/general-and-selective-brain-connectivity-alterations-in-essential-tremor-a-resting-state-fmri-study
#9
Karsten Mueller, Robert Jech, Martina Hoskovcová, Olga Ulmanová, Dušan Urgošík, Josef Vymazal, Evžen Růžička
Although essential tremor is the most common movement disorder, there is little knowledge about the pathophysiological mechanisms of this disease. Therefore, we explored brain connectivity based on slow spontaneous fluctuations of blood oxygenation level dependent (BOLD) signal in patients with essential tremor (ET). A cohort of 19 ET patients and 23 healthy individuals were scanned in resting condition using functional magnetic resonance imaging (fMRI). General connectivity was assessed by eigenvector centrality (EC) mapping...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28912749/functional-connectivity-of-the-corpus-callosum-in-epilepsy-patients-with-secondarily-generalized-seizures
#10
Syu-Jyun Peng, Yue-Loong Hsin
The corpus callosum (CC) plays an important role in generalization of seizure activity. We used resting-state function magnetic resonance imaging (rs-fMRI) to investigate the regional and interregional functional connectivity of CC in patients with magnetic resonance imaging (MRI)-negative and secondarily generalized seizures. We measured the multi-regional coherences of blood oxygen level-dependent (BOLD) signals via rs-fMRI, cortical thickness via high-resolution T1-weighted MRI, and white matter (WM) integrity via diffusion-tensor imaging in 16 epilepsy patients as well as in 16 age- and gender-matched healthy subjects...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28904325/new-medical-education-reform-in-china-towards-healthy-china-2030
#11
Peipei Song, Chunlin Jin, Wei Tang
On July 11, 2017, the State Council of China issued a bold plan to revolutionize medical education and promote collaboration between medical education and practice. The cornerstone of the plan is training more qualified medical professionals to improve public healthcare on the path to Healthy China 2030. According to this plan, a "5+3" training system will be instituted to train medical professionals in China, and top medical colleges will be encouraged to recruit more students. However, given the less-than-ideal professional status of Chinese doctors, the frequent incidents of violence against them, long working hours and a heavy workload, and an unsatisfactory income, attracting personnel to work in medicine and health care has become a challenge...
2017: Bioscience Trends
https://www.readbyqxmd.com/read/28901676/neural-mechanisms-of-motion-perceptual-learning-in-noise
#12
Nihong Chen, Junshi Lu, Hanyu Shao, Xuchu Weng, Fang Fang
Practice improves our perceptual ability. However, the neural mechanisms underlying this experience-dependent plasticity in adult brain remain unclear. Here, we studied the long-term neural correlates of motion perceptual learning. Subjects' behavioral performance and BOLD signals were tracked before, immediately after, and 2 weeks after practicing a motion direction discrimination task in noise over six daily sessions. Parallel to the specificity and persistency of the behavioral learning effect, we found that training sharpened the cortical tuning in MT, and enhanced the connectivity strength from MT to the intraparietal sulcus (IPS, a motion decision-making area)...
September 12, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28895752/airflow-obstruction-and-use-of-solid-fuels-for-cooking-or-heating-bold-results
#13
André F S Amaral, Jaymini Patel, Bernet S Kato, Daniel O Obaseki, Hervé Lawin, Wan C Tan, Sanjay K Juvekar, Imed Harrabi, Michael Studnicka, Emiel F M Wouters, Li-Cher Loh, Eric D Bateman, Kevin Mortimer, A Sonia Buist, Peter G J Burney
RATIONALE: Evidence supporting the association of COPD or airflow obstruction with use of solid fuels is conflicting and inconsistent. OBJECTIVE: To assess the association of airflow obstruction with self-reported use of solid fuels for cooking or heating. METHODS: We analysed 18,554 adults from the BOLD study, who had provided acceptable post-bronchodilator spirometry measurements and information on use of solid fuels. The association of airflow obstruction with use of solid fuels for cooking or heating was assessed by sex, within each site, using regression analysis...
September 12, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28893378/localization-of-spontaneous-bursting-neuronal-activity-in-the-preterm-human-brain-with-simultaneous-eeg-fmri
#14
Tomoki Arichi, Kimberley Whitehead, Giovanni Barone, Ronit Pressler, Francesco Padormo, A David Edwards, Lorenzo Fabrizi
Electroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. Although similar events in animal models are known to occur in areas of immature cortex and drive their development, their origin in humans has not yet been identified. Here, we use simultaneous EEG-fMRI to localise the source of delta brush events in 10 preterm infants aged 32-36 postmenstrual weeks. The most frequent patterns were left and right posterior-temporal delta brushes which were associated in the left hemisphere with ipsilateral BOLD activation in the insula only; and in the right hemisphere in both the insular and temporal cortices...
September 12, 2017: ELife
https://www.readbyqxmd.com/read/28890417/the-impact-of-vessel-size-orientation-and-intravascular-contribution-on-the-neurovascular-fingerprint-of-bold-bssfp-fmri
#15
Mario Gilberto Báez-Yánez, Philipp Ehses, Christian Mirkes, Philbert S Tsai, David Kleinfeld, Klaus Scheffler
Monte Carlo simulations have been used to analyze oxygenation-related signal changes in pass-band balanced steady state free precession (bSSFP) as well as in gradient echo (GE) and spin echo (SE) sequences. Signal changes were calculated for artificial cylinders and neurovascular networks acquired from the mouse parietal cortex by two-photon laser scanning microscopy at 1 μm isotropic resolution. Signal changes as a function of vessel size, blood volume, vessel orientation to the main magnetic field B0 as well as relations of intra- and extravascular and of micro- and macrovascular contributions have been analyzed...
September 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28890416/bayesian-population-receptive-field-modelling
#16
REVIEW
Peter Zeidman, Edward Harry Silson, Dietrich Samuel Schwarzkopf, Chris Ian Baker, Will Penny
We introduce a probabilistic (Bayesian) framework and associated software toolbox for mapping population receptive fields (pRFs) based on fMRI data. This generic approach is intended to work with stimuli of any dimension and is demonstrated and validated in the context of 2D retinotopic mapping. The framework enables the experimenter to specify generative (encoding) models of fMRI timeseries, in which experimental stimuli enter a pRF model of neural activity, which in turns drives a nonlinear model of neurovascular coupling and Blood Oxygenation Level Dependent (BOLD) response...
September 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28889975/consistent-individual-differences-drive-collective-behavior-and-group-functioning-of-schooling-fish
#17
Jolle W Jolles, Neeltje J Boogert, Vivek H Sridhar, Iain D Couzin, Andrea Manica
The ubiquity of consistent inter-individual differences in behavior ("animal personalities") [1, 2] suggests that they might play a fundamental role in driving the movements and functioning of animal groups [3, 4], including their collective decision-making, foraging performance, and predator avoidance. Despite increasing evidence that highlights their importance [5-16], we still lack a unified mechanistic framework to explain and to predict how consistent inter-individual differences may drive collective behavior...
September 1, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28887088/impact-of-the-heart-rate-on-the-shape-of-the-cardiac-response-function
#18
Feliberto de la Cruz, Andy Schumann, Stefanie Köhler, Karl-Jürgen Bär, Gerd Wagner
There is limited understanding about how heart rate (HR) influences the blood-oxygen level dependent (BOLD) signal. While the mechanism by which respiration induces fluctuation in the BOLD signal is relatively well understood, the mechanisms regarding the HR remains unclear. The application of canonical cardiac response function (CRF), or subject-specific CRF, is an effective method for creating nuisance regressors, which can be used to remove cardiac-induced fluctuations in the BOLD signal. However, the relationship between physiological parameters and the characteristics of the CRF has not been systematically investigated...
September 5, 2017: NeuroImage
https://www.readbyqxmd.com/read/28886474/functional-connectivity-of-the-hippocampus-to-the-thalamocortical-circuitry-in-an-animal-model-of-absence-seizures
#19
Seyed Reza Mousavi, Justin A Arcaro, L Stan Leung, Jeffrey R Tenney, Seyed M Mirsattari
OBJECTIVE: Using the gamma-butyrolactone (GBL) rat model of absence seizures, this study investigated the functional connectivity of the hippocampus, thalamus and cerebral cortex before and during absence seizures. METHODS: Functional connectivity between the hippocampus, thalamus and sensory and motor cortecies, were examined by the temporal correlations of the resting state blood-oxygen-level-dependent (BOLD) signal. Functional connectivity between these regions was calculated at baseline, 5min after saline injection, and at 5, 20 and 52min after GBL injection...
August 24, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28885752/dual-echo-asl-contributes-to-decrypting-the-link-between-functional-connectivity-and-cerebral-blow-flow
#20
Silvia F Storti, Ilaria Boscolo Galazzo, Stefania Montemezzi, Gloria Menegaz, Francesca B Pizzini
Arterial spin labeling (ASL) MRI with a dual-echo readout module (DE-ASL) enables noninvasive simultaneous acquisition of cerebral blood flow (CBF)-weighted images and blood oxygenation level dependent (BOLD) contrast. Up to date, resting-state functional connectivity (FC) studies based on CBF fluctuations have been very limited, while the BOLD is still the method most frequently used. The purposes of this technical report were (i) to assess the potentiality of the DE-ASL sequence for the quantification of resting-state FC and brain organization, with respect to the conventional BOLD (cvBOLD) and (ii) to investigate the relationship between a series of complex network measures and the CBF information...
September 8, 2017: Human Brain Mapping
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