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Survivin polymorphism

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https://www.readbyqxmd.com/read/28365965/polymorphisms-of-survivin-31-g-c-gene-are-associated-with-risk-of-urothelial-carcinoma-in-serbian-population
#1
Ljiljana Bogdanovic, Miodrag Lazic, Jelena Bogdanovic, Ivan Soldatovic, Nađa Nikolic, Milena Radunovic, Sanja Radojevic-Skodric, Jelena Milasin, Gordana Basta-Jovanovic
PURPOSE: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene -31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter -31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28188441/factors-that-may-influence-polymorphous-low-grade-adenocarcinoma-growth
#2
Andresa Borges Soares, Elizabeth Ferreira Martinez, Patricia Fernandes Avila Ribeiro, Icleia Siqueira Barreto, Maria Cássia Aguiar, Cristiane Furuse, Marcelo Sperandio, Victor Angelo Montalli, Ney Soares de Araújo, Vera Cavalcanti de Araújo
There is mounting evidence on the importance of some biological processes in tumor growth, such as vascular supply, apoptosis, autophagy, and senescence. We have investigated these processes in polymorphous low-grade adenocarcinoma (PLGA), in an attempt to identify those that are relevant for this particular lesion. We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence...
April 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28018099/understanding-the-role-of-pin1-in-hepatocellular-carcinoma
#3
REVIEW
Chi-Wai Cheng, Ka-Wai Leong, Eric Tse
PIN1 is a peptidyl-prolyl cis/trans isomerase that binds and catalyses isomerization of the specific motif comprising a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) in proteins. PIN1 can therefore induce conformational and functional changes of its interacting proteins that are regulated by proline-directed serine/threonine phosphorylation. Through this phosphorylation-dependent prolyl isomerization, PIN1 fine-tunes the functions of key phosphoproteins (e.g., cyclin D1, survivin, β-catenin and x-protein of hepatitis B virus) that are involved in the regulation of cell cycle progression, apoptosis, proliferation and oncogenic transformation...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27994498/association-between-survivin-genetic-polymorphisms-and-epidermal-growth-factor-receptor-mutation-in-non-small-cell-lung-cancer
#4
Tu-Chen Liu, Ming-Ju Hsieh, Wen-Jun Wu, Ying-Erh Chou, Whei-Ling Chiang, Shun-Fa Yang, Shih-Chi Su, Thomas Chang-Yao Tsao
Survivin is an anti-apoptotic protein that is implicated in the regulation of apoptosis and cell cycle in various types of cancers. The current study explored the effect of survivin gene polymorphisms and EGFR mutations in non-small-cell lung carcinoma (NSCLC) patients. A total of 360 participants, including 291 adenocarcinoma lung cancer and 69 squamous cell carcinoma lung cancer patients, were selected for the analysis of three survivin genetic variants (survivin -31, +9194, and +9809) by using real-time PCR genotyping...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27187043/dna-strand-replacement-mechanism-in-molecular-beacons-encoded-for-the-detection-of-cancer-biomarkers
#5
Magdalena Stobiecka, Agata Chalupa
Signaling properties of a fluorescent hairpin oligonucleotide molecular beacon (MB) encoded to recognize protein survivin (Sur) mRNA have been investigated. The process of complementary target binding to SurMB with 20-mer loop sequence is spontaneous, as expected, and characterized by a high affinity constant (K = 2.51 × 10(16) M(-1)). However, the slow kinetics at room temperature makes it highly irreversible. To understand the intricacies of target binding to MB, a detailed kinetic study has been performed to determine the rate constants and activation energy Ea for the reaction at physiological temperature (37 °C)...
June 2, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/26651826/survivin-polymorphism-is-associated-with-disease-activity-in-rheumatoid-arthritis-patients
#6
Barbara Jenko, Sonja Praprotnik, Saša Čučnik, Žiga Rotar, Matija Tomšič, Vita Dolžan
AIM: Survivin expression was associated with unfavorable and erosive course of rheumatoid arthritis (RA). This is the first study investigating association between BIRC5 polymorphisms, survivin plasma levels and disease activity in RA. PATIENTS & METHODS: A testing group of 123 and validation group of 150 RA patients initially treated with methotrexate monotherapy were genotyped for three BIRC5 promoter polymorphisms. Survivin plasma levels were determined in testing group...
2016: Pharmacogenomics
https://www.readbyqxmd.com/read/26629088/survivin-31-g-c-polymorphism-might-contribute-to-colorectal-cancer-crc-risk-a-meta-analysis
#7
Linhua Yao, Yi Hu, Zhongmin Deng, Jingjing Li
Published data has shown inconsistent findings about the association of survivin -31 G/C polymorphism with the risk of colorectal cancer (CRC). This meta-analysis quantitatively assesses the results from published studies to provide a more precise estimate of the association between survivin -31 G/C polymorphism as a possible predictor of the risk of CRC. We conducted a literature search in the PubMed, Web of Science, and Cochrane Library databases. Stata 12 software was used to calculate the pooled odds ratios (ORs) with 95% confidence intervals (CIs) based on the available data from each article...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26261647/correlation-between-survivin-genetic-polymorphisms-and-lung-cancer-susceptibility
#8
Guifang Guo, Qiang Zhang, Zhengang Yu, Junjuan Li, Zhaolei Ding, Juan Li, Wei Tan
AIMS: The purpose of the study was to analyze the relationship of survivin polymorphisms including -31G/C, -625G/C, 9194A/G and 9809T/C with the susceptibility to lung cancer. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to test the polymorphisms of -31G/C, -625G/C, 9194A/G and 9809T/C in 104 patients with lung cancer and 104 healthy controls. Then, linkage disequilibrium and haplotypes were analyzed by HaploView software...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26112839/survivin-a-molecular-biomarker-in-cancer
#10
REVIEW
Praveen Kumar Jaiswal, Apul Goel, R D Mittal
Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome. Survivin has consistently been identified by molecular profiling analysis to be associated with high tumour grade cancers, different disease survival and recurrence. Polymorphisms in the survivin gene are emerging as powerful tools to study the biology of the disease and have the potential to be used in disease prognosis and diagnosis...
April 2015: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/25918954/association-of-survivin-promoter-polymorphisms-with-inflammatory-bowel-disease-and-response-to-antitumor-necrosis-factor-therapy
#11
COMPARATIVE STUDY
Emmanouela Rapti, Maria Gazouli, Evangelia Legaki, George Karamanolis, Diamantis Thomas, Evangelos Marinos, Ioannis Papaconstantinou
BACKGROUND/AIM: Recent evidence suggests that survivin, a member of the inhibitors of apoptosis family that prevents cell death and regulates cell division is implicated in the pathogenesis of inflammatory bowel disease (IBD). The aim of the study was to identify a possible association between individual genetic variation, IBD susceptibility, and response to infliximab (IFX). MATERIAL AND METHODS: The expression levels of survivin were detected in pathologic areas of fresh tissues and blood samples by real-time reverse transcriptase - polymerase chain reaction (RT-PCR) from IBD patients...
June 2015: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/25890221/identification-of-peptide-specific-tcr-genes-by-in-vitro-peptide-stimulation-and-cdr3-length-polymorphism-analysis
#12
Hongwei Shao, Yanmei Lin, Teng Wang, Yusheng Ou, Han Shen, Changli Tao, Fenglin Wu, Wenfeng Zhang, Huaben Bo, Hui Wang, Shulin Huang
Identification of TCR genes specific for tumor-associated antigens (TAAs) is necessary for TCR gene modification of T cells, which is applied in anti-tumor adoptive T cell therapy (ACT). The usual identification methods are based on isolating single peptide-responding T cells and cloning the TCR gene by in vitro expansion or by single-cell RT-PCR. However, the long and exacting in vitro culture period and demanding operational requirements restrict the application of these methods. Immunoscope is an effective tool that profiles a repertoire of TCRs and identifies significantly expanded clones through CDR3 length analysis...
July 10, 2015: Cancer Letters
https://www.readbyqxmd.com/read/25889770/survivin-and-angiotensin-converting-enzyme-polymorphisms-with-risk-of-colorectal-cancer-a-systematic-review-and-meta-analysis
#13
REVIEW
Xile Zhou, Caizhao Lin
BACKGROUND: Colorectal cancer (CRC) is the most common cause of cancer death worldwide. Numerous studies have identified the roles of survivin -31 G/C and angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms in CRC risk; however, the results remain inconclusive. This study was to investigate associations between these two polymorphisms and CRC susceptibility. METHODS: A comprehensive literature search was conducted to collect relevant case-control studies published between 2000 and 2014...
2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25778034/survivin-and-angiotensin-converting-enzyme-polymorphisms-with-risk-of-colorectal-cancer-a-systematic-review-and-meta-analysis
#14
Xile Zhou, Caizhao Lin
BACKGROUND: Colorectal cancer (CRC) is the most common cause of cancer death worldwide. Numerous studies have identified the roles of survivin -31 G/C and angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms in CRC risk; however, the results remain inconclusive. This study was to investigate associations between these two polymorphisms and CRC susceptibility. METHODS: A comprehensive literature search was conducted to collect relevant case-control studies published between 2000 and 2014...
December 2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25770188/results-questions-perspectives-of-a-study-on-human-polyomavirus-bk-and-molecular-actors-in-prostate-cancer-development
#15
Monica Mischitelli, Anna Bellizzi, Elena Anzivino, Donatella Maria Rodio, Alessandro Sciarra, Vincenzo Gentile, Valeria Pietropaolo
BACKGROUND: Prostate cancer (PC) is a common tumor in Western countries. Several risk factors play significant roles. MYC, BIRC5/survivin, CDC25 and P53 may contribute to PC risk. As demonstrated, human Polyomavirus BK (BKV) could affect cellular homeostasis contributing to PC pathogenesis. MATERIALS AND METHODS: Biological samples were collected from PC patients. Viral RNA was searched using quantitative polymerase chain reaction (PCR), whereas a qualitative PCR was employed to find particular viral sequences...
March 2015: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/25677909/role-of-survivin-re-expression-in-the-development-and-progression-of-non-small-cell-lung-cancer
#16
Jamsheed Javid, Rashid Mir, P K Julka, P C Ray, Alpana Saxena
Survivin is highly expressed in fetal tissue and is completely absent in terminally differentiated cells, but its re-expression has been observed in most human tumors. Presently, we aimed to analyze the possible impact of the survivin gene (-31G > C, rs 9904341) promoter polymorphism on the expression profile of survivin gene and ultimately the role of survivin re-expression in the development and progression of non-small cell lung cancer. A case-control study of 100 non-small cell lung cancer patients and 100 cancer-free healthy controls was conducted...
July 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25613698/epistatic-interaction-between-adiponectin-and-survivin-gene-polymorphisms-in-endometrial-carcinoma
#17
Soheila Aminimoghaddam, Maryam Shahrabi-Farahani, Mohammadreza Mohajeri-Tehrani, Parvin Amiri, Forozande Fereidooni, Bagher Larijani, Gita Shafiee, Mahsa M Amoli
Adiponectin appears to play an important role in the development and progression of several obesity-related malignancies. Also, overexpression of survivin, an inhibitor of apoptosis protein, is associated with increased risk of cancers. The aim of this study was to investigate the association between two polymorphisms in the adiponectin gene and endometrial cancer (EC) risk. We also investigated whether epistasis between surviving and adiponectin gene polymorphisms are associated with EC risk in an Iranian population...
April 2015: Pathology, Research and Practice
https://www.readbyqxmd.com/read/25609982/prognostic-role-of-apoptosis-related-gene-functional-variants-in-advanced-non-small-cell-lung-cancer-patients-treated-with-first-line-platinum-based-chemotherapy
#18
Kai-Yi Tao, Xian-Xing Li, Wei-Zhen Xu, Yin Wang, Shuang-Mei Zhu, Hua-Xia Xie, Wen-Hua Luo, Yan-Jun Xu, Xiao-Ling Xu
BACKGROUND: Single-nucleotide polymorphisms in apoptosis-related genes have been shown to play a role in the efficacy of platinum-based chemotherapy and may influence clinical outcomes. Our study aimed to evaluate the correlations of four functional single-nucleotide polymorphisms - FAS -670 A>G, FAS ligand -844 T>C, survivin -31 G>C, and survivin 9386 C>T - with drug response and clinical outcomes in advanced non-small-cell lung cancer patients who received platinum-based chemotherapy...
2015: OncoTargets and Therapy
https://www.readbyqxmd.com/read/25374237/association-between-survivin-gene-polymorphisms-and-the-susceptibility-to-colon-cancer-development-in-the-turkish-population
#19
COMPARATIVE STUDY
Nesibe Yamak, Kursat Oguz Yaykasli, Umit Yilmaz, Recep Eroz, Ali Kemal Uzunlar, Handan Ankarali, Cem Sahiner, Davut Baltaci
BACKGROUND: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and differantiation. Dysregulation can lead to uncontrolled cell growth and tumor development. Survivin, a member of the IAP family, plays a key role in promotion of cell proliferation as well as inhibition of apoptosis in cancer cells. The aim of this study was to investigate whether specific genetic polymorphisms of survivin could be associated with colon cancer development and progression in a Turkish population...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25344020/a-polymorphism-in-the-promoter-region-of-the-survivin-gene-is-related-to-hemorrhagic-transformation-in-patients-with-acute-ischemic-stroke
#20
Judith Mallolas, Rocío Rodríguez, Carme Gubern, Susanna Camós, Joaquín Serena, Mar Castellanos
Hemorrhagic transformation (HT) of cerebral infarction is a common and serious occurrence following acute ischemic stroke. The expression of survivin, a member of the inhibitor of apoptosis protein family, has been shown to increase after cerebral ischemia. This protein has been mainly located at the microvasculature within the infarcted and peri-infarcted area, so we aimed to investigate whether survivin gene polymorphisms, also known as BIRC5 gene, were associated with HT of cerebral infarction. Polymorphism screening of the BIRC5 gene was performed in 107 patients with a hemispheric ischemic stroke and 93 controls by polymerase chain reaction, single-strand conformation polymorphism and sequencing analysis...
December 2014: Neuromolecular Medicine
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