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Survivin polymorphism

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https://www.readbyqxmd.com/read/27187043/dna-strand-replacement-mechanism-in-molecular-beacons-encoded-for-the-detection-of-cancer-biomarkers
#1
Magdalena Stobiecka, Agata Chalupa
Signaling properties of a fluorescent hairpin oligonucleotide molecular beacon (MB) encoded to recognize protein survivin (Sur) mRNA have been investigated. The process of complementary target binding to SurMB with 20-mer loop sequence is spontaneous, as expected, and characterized by a high affinity constant (K = 2.51 × 10(16) M(-1)). However, the slow kinetics at room temperature makes it highly irreversible. To understand the intricacies of target binding to MB, a detailed kinetic study has been performed to determine the rate constants and activation energy Ea for the reaction at physiological temperature (37 °C)...
June 2, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/26651826/survivin-polymorphism-is-associated-with-disease-activity-in-rheumatoid-arthritis-patients
#2
Barbara Jenko, Sonja Praprotnik, Saša Čučnik, Žiga Rotar, Matija Tomšič, Vita Dolžan
AIM: Survivin expression was associated with unfavorable and erosive course of rheumatoid arthritis (RA). This is the first study investigating association between BIRC5 polymorphisms, survivin plasma levels and disease activity in RA. PATIENTS & METHODS: A testing group of 123 and validation group of 150 RA patients initially treated with methotrexate monotherapy were genotyped for three BIRC5 promoter polymorphisms. Survivin plasma levels were determined in testing group...
2016: Pharmacogenomics
https://www.readbyqxmd.com/read/26629088/survivin-31-g-c-polymorphism-might-contribute-to-colorectal-cancer-crc-risk-a-meta-analysis
#3
Linhua Yao, Yi Hu, Zhongmin Deng, Jingjing Li
Published data has shown inconsistent findings about the association of survivin -31 G/C polymorphism with the risk of colorectal cancer (CRC). This meta-analysis quantitatively assesses the results from published studies to provide a more precise estimate of the association between survivin -31 G/C polymorphism as a possible predictor of the risk of CRC. We conducted a literature search in the PubMed, Web of Science, and Cochrane Library databases. Stata 12 software was used to calculate the pooled odds ratios (ORs) with 95% confidence intervals (CIs) based on the available data from each article...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26261647/correlation-between-survivin-genetic-polymorphisms-and-lung-cancer-susceptibility
#4
Guifang Guo, Qiang Zhang, Zhengang Yu, Junjuan Li, Zhaolei Ding, Juan Li, Wei Tan
AIMS: The purpose of the study was to analyze the relationship of survivin polymorphisms including -31G/C, -625G/C, 9194A/G and 9809T/C with the susceptibility to lung cancer. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to test the polymorphisms of -31G/C, -625G/C, 9194A/G and 9809T/C in 104 patients with lung cancer and 104 healthy controls. Then, linkage disequilibrium and haplotypes were analyzed by HaploView software...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26112839/survivin-a-molecular-biomarker-in-cancer
#6
REVIEW
Praveen Kumar Jaiswal, Apul Goel, R D Mittal
Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome. Survivin has consistently been identified by molecular profiling analysis to be associated with high tumour grade cancers, different disease survival and recurrence. Polymorphisms in the survivin gene are emerging as powerful tools to study the biology of the disease and have the potential to be used in disease prognosis and diagnosis...
April 2015: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/25918954/association-of-survivin-promoter-polymorphisms-with-inflammatory-bowel-disease-and-response-to-antitumor-necrosis-factor-therapy
#7
COMPARATIVE STUDY
Emmanouela Rapti, Maria Gazouli, Evangelia Legaki, George Karamanolis, Diamantis Thomas, Evangelos Marinos, Ioannis Papaconstantinou
BACKGROUND/AIM: Recent evidence suggests that survivin, a member of the inhibitors of apoptosis family that prevents cell death and regulates cell division is implicated in the pathogenesis of inflammatory bowel disease (IBD). The aim of the study was to identify a possible association between individual genetic variation, IBD susceptibility, and response to infliximab (IFX). MATERIAL AND METHODS: The expression levels of survivin were detected in pathologic areas of fresh tissues and blood samples by real-time reverse transcriptase - polymerase chain reaction (RT-PCR) from IBD patients...
June 2015: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/25890221/identification-of-peptide-specific-tcr-genes-by-in-vitro-peptide-stimulation-and-cdr3-length-polymorphism-analysis
#8
Hongwei Shao, Yanmei Lin, Teng Wang, Yusheng Ou, Han Shen, Changli Tao, Fenglin Wu, Wenfeng Zhang, Huaben Bo, Hui Wang, Shulin Huang
Identification of TCR genes specific for tumor-associated antigens (TAAs) is necessary for TCR gene modification of T cells, which is applied in anti-tumor adoptive T cell therapy (ACT). The usual identification methods are based on isolating single peptide-responding T cells and cloning the TCR gene by in vitro expansion or by single-cell RT-PCR. However, the long and exacting in vitro culture period and demanding operational requirements restrict the application of these methods. Immunoscope is an effective tool that profiles a repertoire of TCRs and identifies significantly expanded clones through CDR3 length analysis...
July 10, 2015: Cancer Letters
https://www.readbyqxmd.com/read/25889770/survivin-and-angiotensin-converting-enzyme-polymorphisms-with-risk-of-colorectal-cancer-a-systematic-review-and-meta-analysis
#9
REVIEW
Xile Zhou, Caizhao Lin
BACKGROUND: Colorectal cancer (CRC) is the most common cause of cancer death worldwide. Numerous studies have identified the roles of survivin -31 G/C and angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms in CRC risk; however, the results remain inconclusive. This study was to investigate associations between these two polymorphisms and CRC susceptibility. METHODS: A comprehensive literature search was conducted to collect relevant case-control studies published between 2000 and 2014...
2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25778034/survivin-and-angiotensin-converting-enzyme-polymorphisms-with-risk-of-colorectal-cancer-a-systematic-review-and-meta-analysis
#10
Xile Zhou, Caizhao Lin
BACKGROUND: Colorectal cancer (CRC) is the most common cause of cancer death worldwide. Numerous studies have identified the roles of survivin -31 G/C and angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms in CRC risk; however, the results remain inconclusive. This study was to investigate associations between these two polymorphisms and CRC susceptibility. METHODS: A comprehensive literature search was conducted to collect relevant case-control studies published between 2000 and 2014...
December 2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25770188/results-questions-perspectives-of-a-study-on-human-polyomavirus-bk-and-molecular-actors-in-prostate-cancer-development
#11
Monica Mischitelli, Anna Bellizzi, Elena Anzivino, Donatella Maria Rodio, Alessandro Sciarra, Vincenzo Gentile, Valeria Pietropaolo
BACKGROUND: Prostate cancer (PC) is a common tumor in Western countries. Several risk factors play significant roles. MYC, BIRC5/survivin, CDC25 and P53 may contribute to PC risk. As demonstrated, human Polyomavirus BK (BKV) could affect cellular homeostasis contributing to PC pathogenesis. MATERIALS AND METHODS: Biological samples were collected from PC patients. Viral RNA was searched using quantitative polymerase chain reaction (PCR), whereas a qualitative PCR was employed to find particular viral sequences...
March 2015: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/25677909/role-of-survivin-re-expression-in-the-development-and-progression-of-non-small-cell-lung-cancer
#12
Jamsheed Javid, Rashid Mir, P K Julka, P C Ray, Alpana Saxena
Survivin is highly expressed in fetal tissue and is completely absent in terminally differentiated cells, but its re-expression has been observed in most human tumors. Presently, we aimed to analyze the possible impact of the survivin gene (-31G > C, rs 9904341) promoter polymorphism on the expression profile of survivin gene and ultimately the role of survivin re-expression in the development and progression of non-small cell lung cancer. A case-control study of 100 non-small cell lung cancer patients and 100 cancer-free healthy controls was conducted...
July 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25613698/epistatic-interaction-between-adiponectin-and-survivin-gene-polymorphisms-in-endometrial-carcinoma
#13
Soheila Aminimoghaddam, Maryam Shahrabi-Farahani, Mohammadreza Mohajeri-Tehrani, Parvin Amiri, Forozande Fereidooni, Bagher Larijani, Gita Shafiee, Mahsa M Amoli
Adiponectin appears to play an important role in the development and progression of several obesity-related malignancies. Also, overexpression of survivin, an inhibitor of apoptosis protein, is associated with increased risk of cancers. The aim of this study was to investigate the association between two polymorphisms in the adiponectin gene and endometrial cancer (EC) risk. We also investigated whether epistasis between surviving and adiponectin gene polymorphisms are associated with EC risk in an Iranian population...
April 2015: Pathology, Research and Practice
https://www.readbyqxmd.com/read/25609982/prognostic-role-of-apoptosis-related-gene-functional-variants-in-advanced-non-small-cell-lung-cancer-patients-treated-with-first-line-platinum-based-chemotherapy
#14
Kai-Yi Tao, Xian-Xing Li, Wei-Zhen Xu, Yin Wang, Shuang-Mei Zhu, Hua-Xia Xie, Wen-Hua Luo, Yan-Jun Xu, Xiao-Ling Xu
BACKGROUND: Single-nucleotide polymorphisms in apoptosis-related genes have been shown to play a role in the efficacy of platinum-based chemotherapy and may influence clinical outcomes. Our study aimed to evaluate the correlations of four functional single-nucleotide polymorphisms - FAS -670 A>G, FAS ligand -844 T>C, survivin -31 G>C, and survivin 9386 C>T - with drug response and clinical outcomes in advanced non-small-cell lung cancer patients who received platinum-based chemotherapy...
2015: OncoTargets and Therapy
https://www.readbyqxmd.com/read/25374237/association-between-survivin-gene-polymorphisms-and-the-susceptibility-to-colon-cancer-development-in-the-turkish-population
#15
COMPARATIVE STUDY
Nesibe Yamak, Kursat Oguz Yaykasli, Umit Yilmaz, Recep Eroz, Ali Kemal Uzunlar, Handan Ankarali, Cem Sahiner, Davut Baltaci
BACKGROUND: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and differantiation. Dysregulation can lead to uncontrolled cell growth and tumor development. Survivin, a member of the IAP family, plays a key role in promotion of cell proliferation as well as inhibition of apoptosis in cancer cells. The aim of this study was to investigate whether specific genetic polymorphisms of survivin could be associated with colon cancer development and progression in a Turkish population...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25344020/a-polymorphism-in-the-promoter-region-of-the-survivin-gene-is-related-to-hemorrhagic-transformation-in-patients-with-acute-ischemic-stroke
#16
Judith Mallolas, Rocío Rodríguez, Carme Gubern, Susanna Camós, Joaquín Serena, Mar Castellanos
Hemorrhagic transformation (HT) of cerebral infarction is a common and serious occurrence following acute ischemic stroke. The expression of survivin, a member of the inhibitor of apoptosis protein family, has been shown to increase after cerebral ischemia. This protein has been mainly located at the microvasculature within the infarcted and peri-infarcted area, so we aimed to investigate whether survivin gene polymorphisms, also known as BIRC5 gene, were associated with HT of cerebral infarction. Polymorphism screening of the BIRC5 gene was performed in 107 patients with a hemispheric ischemic stroke and 93 controls by polymerase chain reaction, single-strand conformation polymorphism and sequencing analysis...
December 2014: Neuromolecular Medicine
https://www.readbyqxmd.com/read/25318914/mutation-detection-in-the-promoter-region-of-survivin-gene-on-n-methyl-n-nitrosourea-induced-colon-tumor-model-in-experiment
#17
M Budak, M A Korpinar, T Kalkan, H Tuncel
Survivin (also known as BIRC5) is one of the first reported inhibitors of apoptosis proteins (IAPs), which is an important family of proteins that regulate apoptosis. It is developmentally regulated and expressed during cell differentiation in humans, mice and rat. Survivin is expressed in a series of human cancers and it has been widely accepted that survivin is strongly related to the onset and development of cancer. In the present study, we tried to determine differences in the promoter region of survivin gene in colon tissue samples from N-methyl-N-nitrosourea (MNU) induced rat colon tumor model and control group...
2014: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/24782603/role-of-gene-polymorphisms-in-gastric-cancer-and-its-precursor-lesions-current-knowledge-and-perspectives-in-latin-american-countries
#18
REVIEW
Miguel Angel Chiurillo
Latin America shows one of the highest incidence rates of gastric cancer in the world, with variations in mortality rates among nations or even within countries belonging to this region. Gastric cancer is the result of a multifactorial complex process, for which a multistep model of carcinogenesis is currently accepted. Additionally to the infection with Helicobacter pylori, that plays a major role, environmental factors as well as genetic susceptibility factors are significant players at different stages in the gastric cancer process...
April 28, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/24648609/clinical-significance-of-survivin-expression-in-patients-with-urothelial-carcinoma
#19
Hsin-An Chen, Chih-Ming Su, Hsiao-Yen Hsieh, Chun-Liang Tung, Cheng-Da Hsu, Yuan-Hung Wang, Cheng-Huang Shen
BACKGROUND: Survivin is a member of the inhibitors of apoptosis protein family that plays an important role in carcinogenesis. Here, we examined the association between survivin expression and clinical outcome in urothelial carcinoma of the bladder (UCB). METHODS: A total of 56 histopathologically confirmed UCB patients were recruited from the Department of Urology of Chiayi Christian Hospital from August 2007 to May 2009. Immunohistochemistry (IHC) was used to detect the survivin expression in tumor tissues...
2014: Disease Markers
https://www.readbyqxmd.com/read/24098667/association-of-survivin-polymorphisms-with-tumor-susceptibility-a-meta-analysis
#20
Ying Zhu, Yongguo Li, Shisheng Zhu, Renkuan Tang, Yunzhi Liu, Jianbo Li
BACKGROUND: The survivin polymorphisms have been shown to confer genetic susceptibility to various tumors, but the results are inconsistent. In order to accomplish a more precise estimation of the relationship, a meta-analysis was performed. RESULTS: For rs9904341, a significantly increased tumor risk was found in overall meta-analysis under C/C vs. G/G (OR = 1.40, 95% CI = 1.13-1.74, p = 0.002), dominant (OR = 1.18, 95% CI = 1.01-1.38, p = 0...
2013: PloS One
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